34,107 results match your criteria Cecal Volvulus Imaging


Microbial Intervention as a Novel Target in Treatment of Non-Alcoholic Fatty Liver Disease Progression.

Cell Physiol Biochem 2018 Dec 6;51(5):2123-2135. Epub 2018 Dec 6.

Department of Gastroenterology, Guangzhou Digestive Disease Center, Guangzhou First People's Hospital, the Second Affiliated Hospital of South China University of Technology, Guangzhou,

Background/aims: Emerging evidence suggests a close link between gut microbiota and non-alcoholic fatty liver disease (NAFLD). In this study, we aimed to investigate the association between gut microbiota and the DNA methylation of adiponectin (an adipocyte-specific adipocytokine) in rats, following diet-induced NAFLD.

Methods: 50 male SD rats were randomly divided into five groups with or without a high fat diet (HFD), antibiotics, and probiotics, in order to establish an imbalanced gut microbiota and probiotic treatment model in NAFLD rats. Read More

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December 2018
2 Reads

The composition of a bioprocessed shiitake (Lentinus edodes) mushroom mycelia and rice bran formulation and its antimicrobial effects against Salmonella enterica subsp. enterica serovar Typhimurium strain SL1344 in macrophage cells and in mice.

BMC Complement Altern Med 2018 Dec 5;18(1):322. Epub 2018 Dec 5.

Western Regional Research Center, Agricultural Research Service, U.S. Department of Agriculture, Albany, CA, 94710, USA.

Background: Human infection by pathogenic Salmonella bacteria can be acquired by consuming of undercooked meat products and eggs. Antimicrobial resistance against antibiotics used in medicine is also a major concern. To help overcome these harmful effects on microbial food safety and human health, we are developing novel antimicrobial food-compatible formulations, one of which is described in the present study. Read More

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December 2018
2 Reads

Intestinal microbiota mediates the susceptibility to polymicrobial sepsis-induced liver injury by granisetron generation in mice.

Hepatology 2018 Dec 1. Epub 2018 Dec 1.

Department of Intensive Care Unit, Zhujiang Hospital, Southern Medical University, Guangzhou, China.

Sepsis-induced liver injury is recognized as a key problem in intensive care units (ICUs). The gut microbiota has been touted as an important mediator of liver disease development; however, the precise roles of gut microbiota in regulating sepsis-induced liver injury are unknown. Here, we aimed to investigate the role of the gut microbiota in sepsis-induced liver injury and the underlying mechanism. Read More

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December 2018

[Histological study on the safety of the controllable ileostomy with pipe].

Zhonghua Wei Chang Wai Ke Za Zhi 2018 Nov;21(11):1291-1295

Department of Gastrointestinal Surgery, Provincial Clinical College, Fujian Medical University, Fuzhou 350001, China.

Objective: To investigate the safety of the controllable ileostomy with pipe in view of histology.

Methods: Twenty-eight Beagle dogs undergoing controllable ileostomy with pipe were studied. The special fistula tube with balloon was placed into the hole locating at the cecal root opposing the mesenteric side, and fixed by double knot compression method. Read More

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November 2018

Female mice exhibit less renal mitochondrial injury but greater mortality using a comorbid model of experimental sepsis.

Intern Med Rev (Wash D C) 2018 Oct;4(10)

Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, Little Rock, AR 72205.

Given the inherent heterogeneity of the septic patient population and possible comorbid conditions, it is not surprising that the influence of gender on incidence and outcomes are still unclear. The goal of this study was to use a clinically relevant murine model of sepsis, cecal ligation and puncture (CLP) in CD1 mice, with and without uniphrectomy as a comorbid condition to investigate possible gender differences in renal mitochondrial function and dynamics. High resolution respirometry on fresh kidney biopsies was used to measure renal respiratory complex activities. Read More

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October 2018

Differences in overall survival and mutation prevalence between right- and left-sided colorectal adenocarcinoma.

J Gastrointest Oncol 2018 Oct;9(5):778-784

Medical Oncology, Cancer Treatment Centers of America, Philadelphia, PA, USA.

Background: Prior reports have demonstrated inferior outcomes for patients with right-sided colorectal cancer (CRC) compared to patients with left-sided disease, as well as differences in treatment response based on disease sidedness. Differences in prognosis remain even among patients with metastatic disease, indicating that anatomy or stage at diagnosis alone cannot explain all of these findings. While genetic differences between right- and left-sided CRC have long been described, the genetic and molecular drivers underlying differences in prognosis and treatment response remain incompletely understood. Read More

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October 2018

Circulating histone H3 levels are increased in septic mice in a neutrophil-dependent manner: preclinical evaluation of a novel sandwich ELISA for histone H3.

J Intensive Care 2018 26;6:79. Epub 2018 Nov 26.

1Department of Systems Biology in Thromboregulation, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.

Background: Nuclear histone proteins are released into the extracellular space during sepsis and act as major mediators of death. However, circulating histone levels have not been precisely quantified.

Methods: We developed a novel enzyme-linked immunosorbent assay (ELISA) for detection of circulating histone H3 levels and evaluated its performance. Read More

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November 2018

Mixed mucosal-parenteral immunizations with the broadly conserved pathogenic Escherichia coli antigen SslE induce a robust mucosal and systemic immunity without affecting the murine intestinal microbiota.

Vaccine 2018 Nov 29. Epub 2018 Nov 29.

GSK, Siena, Italy. Electronic address:

Emergence and dissemination of multidrug resistance among pathogenic Escherichia coli have posed a serious threat to public health across developing and developed countries. In combination with a flexible repertoire of virulence mechanisms, E. coli can cause a vast range of intestinal (InPEC) and extraintestinal (ExPEC) diseases but only a very limited number of antibiotics still remains effective against this pathogen. Read More

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November 2018

Successful Treatment of the Gastrointestinal Manifestation of Prototheca in a Kidney Transplant Recipient: A Case Report.

Transplant Proc 2018 Aug 10. Epub 2018 Aug 10.

Department of Transplantation and Surgery, Semmelweis University, Budapest, Hungary.

Introduction: The Prototheca species are achlorophyllic algae and they are recognized pathogens in animals. They have been reported to cause infections in humans; the majority of the infected patients are immunocompromised. Organ transplant recipients are at risk of infection caused by such unusual organisms. Read More

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Sodium tanshinone IIA sulfonate attenuates cardiac dysfunction and improves survival of rats with cecal ligation and puncture-induced sepsis.

Chin J Nat Med 2018 Nov;16(11):846-855

State Key Laboratory of Pharmaceutical Biotechnology, Medical School, Nanjing University, Nanjing 210093, China. Electronic address:

Cardiac dysfunction, a common consequence of sepsis, is the major contribution to morbidity and mortality in patients. Sodium tanshinone IIA sulfonate (STS) is a water-soluble derivative of Tanshinone IIA (TA), a main active component of Salvia miltiorrhiza Bunge, which has been widely used in China for the treatment of cardiovascular and cerebral system diseases. In the present study, the effect of STS on sepsis-induced cardiac dysfunction was investigated and its effect on survival rate of rats with sepsis was also evaluated. Read More

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November 2018

Klotho deficiency aggravates sepsis-related multiple organ dysfunction.

Am J Physiol Renal Physiol 2018 Dec 5. Epub 2018 Dec 5.

Internal Medicine - Nephrology, University of Sao Paulo School of Medicine, Brazil.

Sepsis-induced organ failure is characterized by a massive inflammatory response and oxidative stress. Acute kidney injury (AKI) occurs in approximately half of patients in septic shock, and the mortality associated with sepsis-induced AKI is unacceptably high. Klotho is a protein expressed by renal cells and has anti-senescence properties. Read More

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December 2018

Modulation of intestinal microbiota, morphology and mucin composition by dietary insect meal inclusion in free-range chickens.

BMC Vet Res 2018 Dec 4;14(1):383. Epub 2018 Dec 4.

Department of Veterinary Sciences, University of Turin, Largo Paolo Braccini 2, 10095, Grugliasco, TO, Italy.

Background: Gut health in poultry depends on the balance between the host, intestinal microbiota, intestinal microscopic features and diet. The effects of insect meal (a promising alternative protein source for poultry feed) on chicken gut morphology have recently been reported, but no data about intestinal microbiota and mucin composition modulation are available. The present study evaluated the effects of dietary Tenebrio molitor (TM) meal inclusion on gut health of free-range chickens by intestinal microbiota, morphology and mucin composition characterization. Read More

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December 2018
1 Read

Disseminated cryptococcosis in Crohn's disease: a case report.

BMC Infect Dis 2018 Dec 4;18(1):620. Epub 2018 Dec 4.

Division of Infectious Diseases and Tropical Medicine, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, 2 Wanglang Road, Bangkoknoi, Bangkok, 10700, Thailand.

Background: Gastrointestinal (GI) cryptococcosis is rarely reported. Most cases were diagnosed during evaluation of comorbid conditions, incidental findings, or postmortem. Here, we present a case of Crohn's disease with gastrointestinal cryptococcosis that resembled exacerbation of Crohn's disease. Read More

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December 2018

Colonic metastasis from infiltrating ductal breast carcinoma in a male patient: A case report.

Int J Surg Case Rep 2018 Nov 16;54:34-38. Epub 2018 Nov 16.

Department of Surgery, Palmetto Healthcare System, University of South Carolina Medical School, 2 Medical Park Road, Columbia, SC 29203, United States. Electronic address:

Introduction: A colonic metastasis from infiltrating breast ductal carcinoma is a rare phenomenon in the literature, especially in a male.

Presentation Of Case: We present a rare case of a 55-year-old male with a past medical history of breast cancer who presented with signs and symptoms of appendicitis. A computed tomography (CT) scan revealed acute appendicitis in addition to a 2. Read More

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November 2018
5 Reads

Prebiotic, Immunomodulating, and Antifatigue Effects of Konjac Oligosaccharide.

J Food Sci 2018 Dec 4. Epub 2018 Dec 4.

Natl. Engineering Laboratory for Industrial Enzymes, Tianjin Inst. of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, 300308, China.

Irregular and long time work schedules not only makes people feel fatigue, but also brings great risks of diseases, due to gastrointestinal disorder and immune dysfunction. Therefore, it has positive significance to help challenged people stay energetic and healthy with food supplement. Konjac oligosaccharide has shown various physiological benefits and been recommended in the fortification of functional foods. Read More

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December 2018
2 Reads

Characterization, the Antioxidant and Antimicrobial Activity of Exopolysaccharide Isolated from Poultry Origin Lactobacilli.

Probiotics Antimicrob Proteins 2018 Dec 3. Epub 2018 Dec 3.

Key Laboratory for Space Bioscience and Space Biotechnology, School of Life Sciences, Northwestern Polytechnical University, Xi'an, 710072, Shaanxi, People's Republic of China.

The natural antioxidant agent is urgently needed to prevent the negative effects of newly generated free radicals and chronic disorders. Recently, the microbial exopolysaccharide (EPS) is currently used as a potential biopolymer due to its unique biological characteristics. In this study, the biological potential was carried out on the EPSs produced by Lactobacillus reuteri SHA101 (EPS-lr) and Lactobacillus vaginalis SHA110 (EPS-lvg) isolated from gut cecum samples of healthy poultry birds (hen). Read More

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December 2018

Sepsis Induces a Long-Lasting State of Trained Immunity in Bone Marrow Monocytes.

Front Immunol 2018 19;9:2685. Epub 2018 Nov 19.

Department of Anesthesiology, Heidelberg University Hospital, Heidelberg, Germany.

Innate immune memory describes the functional reprogramming of innate immune cells after pathogen contact, leading to either a boosted (trained immunity) or a diminished (immune tolerance) response to a secondary stimulus. Immune tolerance or "sepsis-induced immunosuppression" is a typical hallmark of patients after sepsis survival, characterized by hypo-responsiveness of the host's immune system. This condition renders the host vulnerable for a persisting infection or the occurrence of secondary, often opportunistic infections, along with an increased mortality rate. Read More

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November 2018
1 Read

Successful surgical resolution of a ceco-cecal intussusception in a 15-month-old Angus heifer.

Can Vet J 2018 Oct;59(10):1071-1074

Department of Clinical Sciences, College of Veterinary Medicine, Auburn University, Auburn, Alabama 36849, USA.

A 15-month-old Angus heifer was presented for anorexia and abdominal discomfort. Transabdominal ultrasound was suggestive of a ceco-cecal intussusception. Exploratory laparotomy confirmed the diagnosis and a cecectomy was performed. Read More

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October 2018

Protective Effect of Citrulline on the Hearts of Rats with Sepsis Induced by Cecal Ligation and Puncture.

Biomed Res Int 2018 18;2018:2574501. Epub 2018 Oct 18.

Department of Colorectal Surgery, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi 530021, China.

Purpose: To investigate the protective effect of citrulline (Cit) on the hearts of rats with sepsis.

Methods: Wistar rats were divided into the normal, sham-operated, CLP, Cit, and CLP+Cit groups. Routine blood tests were performed, and the blood biochemical indexes were measured. Read More

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October 2018

Suppressive effects of rare ginsenosides, Rk1 and Rg5, on HMGB1-mediated septic responses.

Food Chem Toxicol 2018 Nov 26;124:45-53. Epub 2018 Nov 26.

College of Pharmacy, CMRI, Research Institute of Pharmaceutical Sciences, BK21 Plus KNU Multi-Omics based Creative Drug Research Team, Kyungpook National University, Daegu, 41566, Republic of Korea. Electronic address:

High mobility group box 1 (HMGB1) is considered to be a late mediator of sepsis. The inhibition of HMGB1-mediated severe inflammatory response and restoration of endothelial integrity have emerged as attractive therapeutic strategies for the management of sepsis. Rare ginsenosides, Rk1 (SB1) and Rg5 (SB2), are among the main components of black ginseng and are prepared from ginsenoside Rd by steaming at 120 °C for 3 h. Read More

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November 2018

Effects of dietary supplementation of alfalfa meal on growth performance, carcass characteristics, meat and egg quality, and intestinal microbiota in Beijing-you chicken.

Poult Sci 2018 Nov 29. Epub 2018 Nov 29.

Beijing Research and Development Center for Grass and Environment, Beijing Academy of Agriculture and Forestry Sciences, Beijing 100097, China.

This study was conducted to investigate the effects of alfalfa meal supplementation on growth performance, carcass characteristics, meat and egg quality, and intestinal microbiota in chickens. A total of 600 healthy 20-wk female Beijing-you chickens (a local Chinese chicken breed) were selected and randomly assigned into 4 dietary treatments: 0, 5, 8, and 10% alfalfa meal supplementation. Chickens were raised in a free-range system for 56 d. Read More

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November 2018
1 Read

Community-Level Physiological Profiling for Microbial Community Function in Broiler Ceca.

Curr Microbiol 2018 Nov 28. Epub 2018 Nov 28.

Poultry Microbiological Safety and Processing Research Unit, U.S. National Poultry Research Center, Agricultural Research Service, U.S. Department of Agriculture, 950 College Station Road, Athens, GA, 30605-2720, USA.

Poultry production is a major agricultural output worldwide. It is known that the gut health of broilers is essential for their growth and for providing wholesome products for human consumption. Previously, the microbial diversity of broiler ceca was studied at the genetic level. Read More

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November 2018
1 Read

SIRT3 Protects Against Acute Kidney Injury via AMPK/mTOR-Regulated Autophagy.

Front Physiol 2018 14;9:1526. Epub 2018 Nov 14.

Department of Organ Transplantation, Changhai Hospital, Second Military Medical University, Shanghai, China.

Acute kidney injury (AKI), which involves the loss of kidney function caused by damage to renal tubular cells, is an important public health concern. We previously showed that sirtuin (SIRT)3 protects the kidneys against mitochondrial damage by inhibiting the nucleotide-binding domain (NOD)-like receptor protein 3 (NLRP3) inflammasome, attenuating oxidative stress, and downregulating proinflammatory cytokines. In this article, we investigated the role of autophagy, mediated by a mammalian target of rapamycin (mTOR) and AMP-activated protein kinase (AMPK), in the protective effect of SIRT3, against sepsis-induced AKI, in a mouse model of cecal ligation and puncture (CLP). Read More

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November 2018
3 Reads

Morphometric Analysis of the Intestine in Experimental Coccidiosis in Broilers Treated with Anticoccidial Drugs.

Iran J Parasitol 2018 Jul-Sep;13(3):493-499

Dept. of Clinical Sciences, Faculty of Veterinary Medicine, University of Tehran, Iran.

Background: Coccidiosis causes morphologic alteration in intestinal mucosa resulting in reduction of absorptive surface. Anticoccidials used as feed additives may induce changes in the intestinal mucosa. This study was designed to assess intestinal morphometry in broilers infected with under different anticoccidial treatments. Read More

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November 2018

[Influence of vagus nerve on multiple organ function and immune reaction of T lymphocytes in septic rats].

Zhonghua Shao Shang Za Zhi 2018 Nov;34(11):815-820

Trauma Research Center, the First Hospital Affiliated to the PLA General Hospital, Beijing 100048, China.

To explore influence of vagus nerve on multiple organ function and immune reaction of T lymphocytes in septic rats. Forty Sprague-Dawley rats were divided into sham injury group, sepsis group, vagus nerve stimulation (VNS) group, and vagotomy (VGX) group, according to the random number table, with 10 rats in each group. Rats in sepsis group, VNS group, and VGX group were inflicted with sepsis by cecal ligation and puncture (CLP). Read More

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November 2018
4 Reads

Appendiceal neurofibroma with low-grade appendiceal mucinous neoplasm in neurofibromatosis type 1 patient: A case report.

Int J Surg Case Rep 2018 Nov 13;53:377-380. Epub 2018 Nov 13.

Department of Gastroenterological Surgery, Hiroshima City Asa Citizens Hospital, Japan.

Introduction: Neurofibromas are a characteristic of the autosomal dominant disorder Neurofibromatosis type 1 (NF1), also known as von Recklinghausen's disease. Appendiceal neurofibromas are extremely rare, and low-grade appendiceal mucinous neoplasms (LAMNs) have not previously been reported in NF1.

Presentation Of Case: A 62-year-old man with NF1 was scheduled for elective surgical treatment of an asymptomatic, enlarged and diffusely thickened appendix that remained after curative antimicrobial treatment of acute appendicitis. Read More

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November 2018
3 Reads

Responses of broiler chickens to Eimeria challenge when fed a nucleotide-rich yeast extract.

Poult Sci 2018 Nov 27. Epub 2018 Nov 27.

Department of Animal Biosciences, University of Guelph, Guelph, ON N1G 2W1, Canada.

Nucleotide-rich yeast extract (YN) was investigated for effects on growth performance, jejunal physiology, and cecal microbial activity in Eimeria-challenged broiler chickens. A total of 360-day-old male chicks (Ross × Ross 708) were placed on floor pens and provided a corn-soybean meal-based diet without or with YN (500 g/MT; n = 12). On d 10, 6 replicates per diet were orally administered with 1 mL of E. Read More

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November 2018

An Incidental Subepithelial Cecal Lesion.

GE Port J Gastroenterol 2018 Nov 27;25(6):335-336. Epub 2018 Feb 27.

Department of Gastroenterology, Centro Hospitalar Lisboa Ocidental, Hospital de Egas Moniz, Lisbon, Portugal.

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November 2018

High Efficacy of Repeating Colonoscopy by an Advanced Endoscopist after an Incomplete Colonoscopy.

GE Port J Gastroenterol 2018 Nov 6;25(6):285-290. Epub 2018 Feb 6.

Department of Gastroenterology, Centro Hospitalar Vila Nova de Gaia/Espinho, Vila Nova de Gaia, Portugal.

Background And Aims: This study aims to evaluate the role of an advanced endoscopist to study the entire colon after an incomplete colonoscopy.

Methods: All patients with an elective incomplete colonoscopy performed under deep sedation in our department between January 2010 and October 2016 were included. Patients with a colonic stenosis, an inadequate bowel preparation, or a colonoscopy performed without deep sedation were excluded. Read More

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November 2018
3 Reads

Association between hypokalemia and small bowel capsule endoscopy completion rates in patients in South China: A prospective single-center study.

Saudi J Gastroenterol 2018 Nov 27. Epub 2018 Nov 27.

Department of Gastroenterology, Qingyuan People's Hospital, The Sixth Affiliated Hospital of Guangzhou Medical University, Guangdong, China.

Background/aims: Approximately 20-30% of small bowel capsule endoscopies (SBCEs) do not reach the cecum at the completion of the examination. We aimed to determine whether hypokalemia influences the completion rate and small bowel transit time (SBTT) of SBCE.

Patients And Methods: From January to December 2017, 112 patients (18-75 years old) who underwent SBCE were assessed consecutively for enrolment in our study. Read More

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November 2018
1 Read

Findings during screening colonoscopies in a Middle Eastern cohort.

Saudi J Gastroenterol 2018 Nov 27. Epub 2018 Nov 27.

Division of Gastroenterology, King Khalid University Hospital, King Saud University, Riyadh, Saudi Arabia.

Background/aims: Colorectal cancer is the most common cancer in males and the third most common cancer in females. We aim to determine the polyp and adenoma prevalence in a cohort of patients who underwent opportunistic screening colonoscopies.

Patients And Methods: A retrospective cohort study was conducted using an endoscopic reporting database of individuals seen at three tertiary care hospitals (two public hospitals and one private) in Riyadh, Saudi Arabia. Read More

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November 2018
3 Reads

Comparative transcriptome analysis reveals PERP upregulated during Salmonella Enteritidis challenge in laying ducks.

J Cell Physiol 2018 Nov 27. Epub 2018 Nov 27.

Joint International Research Laboratory of Agriculture & Agri-Product Safety of Ministry of Education, Yangzhou University, Yangzhou, China.

Salmonella Enteritidis (SE) can be transmitted to eggs through cecum or the ovary from infected layers and causes food poisoning in humans. The mechanism of cecal transmission has been extensively studied. However, the mechanism and route of transovarian transmission of SE remain unclear. Read More

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November 2018
2 Reads
3.840 Impact Factor

Probiotic Lactobacillus gasseri SBT2055 improves insulin secretion in a diabetic rat model.

J Dairy Sci 2018 Nov 21. Epub 2018 Nov 21.

Laboratory of Nutrition Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Graduate School, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka 819-0395, Japan. Electronic address:

The probiotic Lactobacillus gasseri SBT2055 (LG2055) has a protective effect against metabolic syndrome in rats and humans. Metabolic syndrome increases the risk of type 2 diabetes mellitus. In this study, Goto-Kakizaki rats were used as a diabetic model and fed diets containing LG2055-fermented or nonfermented skim milk for 4 wk. Read More

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November 2018
5 Reads

Laparoscopic repair of secondary perineal hernia with coverage by the mobilized cecum.

Asian J Endosc Surg 2018 Nov 23. Epub 2018 Nov 23.

Division of Gastroenterological Surgery, Department of Surgery, Aichi Medical University, Nagakute, Japan.

The incidence of secondary perineal hernia (SPH) has increased since the introduction of extralevator abdominoperineal resection and laparoscopic abdominoperineal resection. Currently, laparoscopic mesh repair is the usual procedure. Here, we demonstrate a repair of SPH without mesh that uses the mobilized cecum to cover the pelvic hernial orifice. Read More

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November 2018
5 Reads

Sigmoido-Cecal Fistula: A Rare Case of Complicated Recurrent Diverticulitis and a Review of the Literature.

Am J Case Rep 2018 Nov 22;19:1386-1392. Epub 2018 Nov 22.

Third Department of Surgery, AHEPA University Hospital, Aristotle University of Thessaloniki, School of Health Sciences, Faculty of Medicine, Thessaloniki, Greece.

BACKGROUND Although diverticular disease is well described and treated in daily clinical practice, there are cases that attract great interest because of their complexity and difficulty in management. Herein, we describe a rare case of colo-colonic fistula-complicated diverticulitis that necessitated urgent surgical intervention. CASE REPORT A 76-year-old female patient with a known history of diverticular disease of the sigmoid colon presented in the Emergency Department for evaluation of left lower quadrant abdominal pain. Read More

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November 2018
4 Reads

Effect of Simvastatin on the Intestinal Rho/ROCK Signaling Pathway in Rats With Sepsis.

J Surg Res 2018 Dec 3;232:531-538. Epub 2018 Aug 3.

Emergency Department, Shengjing Hospital affiliated to China Medical University, Shenyang, Liaoning Province, China.

Background: Simvastatin may alleviate the intestinal barrier dysfunction induced by sepsis. This study aimed to investigate the role of the Ras homolog (Rho)/Rho-associated coiled-coil forming protein kinase (ROCK) signaling pathway in the intestinal barrier of simvastatin-treated rats with sepsis.

Materials And Methods: Male Wistar rats were pretreated with simvastatin (0. Read More

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December 2018
8 Reads

Pathobiological and Genomic Characterization of a Cold-Adapted Infectious Bronchitis Virus (BP-caKII).

Viruses 2018 Nov 19;10(11). Epub 2018 Nov 19.

Reseach Institute for Veterinary Science, College of Veterinary Medicine, BK21 for Veterinary Science, Seoul 08826, Korea.

We established a cold-adapted infectious bronchitis virus (BP-caKII) by passaging a field virus through specific pathogen-free embryonated eggs 20 times at 32 °C. We characterized its growth kinetics and pathogenicity in embryonated eggs, and its tropism and persistence in different tissues from chickens; then, we evaluated pathogenicity by using a new premature reproductive tract pathogenicity model. Furthermore, we determined the complete genomic sequence of BP-caKII to understand the genetic changes related to cold adaptation. Read More

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November 2018
2 Reads

Adiponectin is protective against endoplasmic reticulum stress-induced apoptosis of endothelial cells in sepsis.

Braz J Med Biol Res 2018 Nov 14;51(12):e7747. Epub 2018 Nov 14.

Department of Histology and Embryology, Binzhou Medical University, Yan Tai, China.

Endoplasmic reticulum (ER) stress is a critical molecular mechanism involved in the pathogenesis of sepsis. Hence, strategies for alleviating this stress may be essential for preventing cardiovascular injuries under sepsis. Adiponectin is secreted by adipocytes and its levels are decreased in sepsis. Read More

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November 2018
2 Reads

Glycyrrhizin Attenuates Serovar Typhimurium Infection: New Insights Into Its Protective Mechanism.

Front Immunol 2018 16;9:2321. Epub 2018 Oct 16.

Key Laboratory of Molecular Animal Nutrition of the Ministry of Education, Institute of Feed Science, College of Animal Sciences, Zhejiang University, Hangzhou, China.

Glycyrrhizin (GL), a triterpenoid glycoside, serves important functions in various biological activities, including antiviral and antitumor immune responses. However, the anti-inflammatory effects of GL on serovar Typhimurium (ST)-induced injury in mice and the mechanisms underlying the protection of GL are poorly understood. Here, we investigated the effects of GL on host immune responses against ST infection in mice. Read More

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October 2018
2 Reads

Involvement of JNK signaling pathway in lipopolysaccharide-induced complement C3 transcriptional activation from amphioxus Branchiostoma belcheri.

Fish Shellfish Immunol 2018 Nov 17;86:196-203. Epub 2018 Nov 17.

Institute of Oceanography, Minjiang University, Fuzhou 350108, PR China. Electronic address:

Complement C3 is a pivotal component of three cascades of complement activation. C3 in circulation is mainly provided by the hepatic cecum. The expression and secretion of C3 by hepatocytes is increased during acute inflammation. Read More

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November 2018
4 Reads

Lactobacillus elicits a 'Marmite effect' on the chicken cecal microbiome.

NPJ Biofilms Microbiomes 2018 9;4:27. Epub 2018 Nov 9.

Program in Molecular Medicine, Hospital for Sick Children, Peter Gilgan Center for Research and Learning, 686 Bay Street, Toronto, ON M5G 0A4 Canada.

The poultry industry has traditionally relied on the use of antibiotic growth promoters (AGPs) to improve production efficiency and minimize infection. With the recent drive to eliminate the use of AGPs, novel alternatives are urgently required. Recently attention has turned to the use of synthetic communities that may be used to 'seed' the developing microbiome. Read More

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November 2018
4 Reads

The GTPase Rab1 Is Required for NLRP3 Inflammasome Activation and Inflammatory Lung Injury.

J Immunol 2018 Nov 19. Epub 2018 Nov 19.

Department of Anesthesiology, University of Illinois College of Medicine, Chicago, IL 60612;

Uncontrolled inflammatory response during sepsis predominantly contributes to the development of multiorgan failure and lethality. However, the cellular and molecular mechanisms for excessive production and release of proinflammatory cytokines are not clearly defined. In this study, we show the crucial role of the GTPase Ras-related protein in brain (Rab)1a in regulating the nucleotide binding domain-like receptor family, pyrin domain containing 3 (NLRP3) inflammasome activation and lung inflammatory injury. Read More

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November 2018
5 Reads

Glucosamine improves survival in a mouse model of sepsis and attenuates sepsis-induced lung injury and inflammation.

J Biol Chem 2018 Nov 19. Epub 2018 Nov 19.

Physiology and Biophysics, Inha University, Korea, Republic of.

The aim of the current study was to investigate the effects of glucosamine (GlcN) on septic lethality and sepsis-induced inflammation using animal models of mice and zebrafish. GlcN pretreatment improved survival in the cecal ligation and puncture (CLP)-induced sepsis mouse model and attenuated LPS-induced septic lung injury and systemic inflammation. GlcN suppressed LPS-induced M1-specific but not M2-specific gene expression. Read More

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November 2018
3 Reads

[Effect of long-term intake of ginseng extracts on gut microbiota in rats].

Zhongguo Zhong Yao Za Zhi 2018 Oct;43(19):3927-3932

Ministry of Education Key Laboratory of Systems Biomedicine, Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai 200240, China.

As a traditional Chinese medicine in China, ginseng has a wide range of medicinal and health value. At present, the nutritional value of ginseng as a medicinal food has been a hotspot in studies. Intestinal flora plays an important role in the organism, which has been confirmed by many researchers. Read More

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October 2018
4 Reads

Dietary Cold Pressed Watercress and Coconut Oil Mixture Enhances Growth Performance, Intestinal Microbiota, Antioxidant Status, and Immunity of Growing Rabbits.

Animals (Basel) 2018 Nov 17;8(11). Epub 2018 Nov 17.

Department of Animal Production, College of Food and Agriculture Sciences, King Saud University, P.O. Box 2460, Riyadh 11451, Saudi Arabia.

The present study assessed the effect of dietary supplementation with coconut oil (CNO), watercress oil (WCO), and their mixture as promoters of growth, antioxidant status, immunity, and intestinal microbiota in growing rabbits. A total of 120 rabbits were distributed into six groups (20 rabbits/group) receiving a basal diet without supplementation (G1) or diet supplemented with 2 g CNO (G2), 2 g WCO (G3), 0.5 g CNO plus 1. Read More

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November 2018
1 Read

Novel Role of p53 in Septic Immunosuppression: Involvement in Loss and Dysfunction of CD4+ T Lymphocytes.

Cell Physiol Biochem 2018 19;51(1):452-469. Epub 2018 Nov 19.

Background/aims: Immunosuppression frequently occurs during the development of sepsis and is closely associated with poor outcome. Characteristics of immunosuppressive CD4+ T lymphocytes in sepsis have been reported to include dramatic cell loss and inactivation. p53 acts as a pivotal transcription factor in regulating cell proliferation and apoptosis, which control tumorigenesis. Read More

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November 2018
9 Reads

Efficacy of autofluorescence imaging for flat neoplasm detection: a multicenter randomized controlled trial (A-FLAT trial).

Gastrointest Endosc 2018 Nov 16. Epub 2018 Nov 16.

Endoscopy Division, National Cancer Center Hospital, Japan.

Background & Aims: Colorectal flat (nonpolypoid) lesions can be overlooked during colonoscopy. This study evaluated the efficacy of updated autofluorescence imaging (AFI) for detecting colorectal flat neoplasms.

Methods: This was a prospective, multicenter, randomized controlled trial in 9 Japanese tertiary institutions. Read More

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November 2018
4 Reads

The impact of Bacillus subtilis DSM 32315 on the pathology, performance, and intestinal microbiome of broiler chickens in a necrotic enteritis challenge.

Poult Sci 2018 Nov 18. Epub 2018 Nov 18.

Alimetrics Ltd, Espoo, 02920, Finland.

It was hypothesized that dietary inclusion of Bacillus subtilis DSM 32315 could inhibit Clostridium perfringens induced necrotic enteritis (NE), thereby improving broiler performance. Male, d 0 chicks were randomly assigned 14 birds/pen, 11 pens/treatment in 3 treatments: a basal diet (control), a coccidiostat fed control (Narasin), and a direct fed microbial (DFM) B. subtilis DSM 32315 treatment. Read More

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November 2018
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