1,155 results match your criteria Cavernous Sinus Syndromes


Cavernous sinus lesions.

Clin Imaging 2020 Jun 18;68:71-89. Epub 2020 Jun 18.

NYU Langone Health, Department of Radiology, New York, NY, United States of America. Electronic address:

The cavernous sinus is a complex structure susceptible to a wide variety of vascular, neoplastic and inflammatory pathologies. Vascular pathologies include ICA aneurysms, carotid-cavernous fistulas, cavernous sinus thrombosis, and cavernous hemangioma. Neoplasms that involve the cavernous sinus include pituitary adenoma, meningioma, schwannoma, lymphoma, perineural tumor spread, metastases, and direct tumor invasion. Read More

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http://dx.doi.org/10.1016/j.clinimag.2020.06.029DOI Listing

Cavernous Thrombophlebitis Secondary to Cavernous Internal Carotid Mycotic Aneurysm.

Neurohospitalist 2020 Jul 6;10(3):221-223. Epub 2019 Dec 6.

Department of Neurology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.

We report a case of a 22-year-old male with a history of intravenous drug use presenting with cavernous sinus syndrome secondary to cavernous thrombophlebitis. The source of the thrombophlebitis was from a mycotic aneurysm in the setting of fungal endocarditis. With antifungal therapy and aortic valve replacement, the patient had full resolution of cranial nerve deficits. Read More

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http://dx.doi.org/10.1177/1941874419892441DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7271614PMC

Evolution of Developmental Venous Anomalies in the Setting of a Torcular Dural Arteriovenous Fistula and Cerebrofacial Venous Metameric Syndrome.

World Neurosurg 2020 Jun 12. Epub 2020 Jun 12.

Departments of Radiology, Neurology and Neurosurgery, Mayo Clinic Rochester, MN.

We describe evolution of a DVA over time in a patient with a complex intracranial vascular malformation. A 26 year-old male initially presented with a scalp vascular malformation and was later diagnosed to have a torcular dural arteriovenous fistula resembling a dural sinus malformation. The dural fistula increased in size over four years. Read More

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http://dx.doi.org/10.1016/j.wneu.2020.06.035DOI Listing

Perineuritis or infiltration of optic nerve sheath? A presentation of diffuse large B cell Gastric lymphoma.

Indian J Ophthalmol 2020 Jun;68(6):1212-1214

Dr. Rajendra Prasad Centre for Ophthalmic Sciences, New Delhi, India.

Optic perineuritis is an inflammatory disorder involving the optic nerve sheath. It is currently considered as a part of idiopathic orbital inflammatory disease which also includes dacryoadenitis, orbital myositis, superior orbital fissure, and cavernous sinus syndrome (Tolosa hunt syndrome). As it is idiopathic, it is considered a diagnosis of exclusion. Read More

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http://dx.doi.org/10.4103/ijo.IJO_711_19DOI Listing
June 2020
0.927 Impact Factor

Resection of Invasive Sphenoorbital and Cavernous Sinus Meningioma via Frontotemporal Craniotomy.

World Neurosurg 2020 May 13. Epub 2020 May 13.

Department of Neurosurgery, Clinical Neurosciences Center, University of Utah, Salt Lake City, Utah, USA. Electronic address:

Spheno-orbital meningiomas require extensive bone removal around the superior and lateral orbital walls, superior orbital fissure, and anterior middle fossa floor. Incomplete resection can lead to recurrence or growth into the cavernous sinus (CS). This case involved a 46-year-old woman with history of childhood leukemia treated with chemotherapy and whole-body radiation. Read More

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http://dx.doi.org/10.1016/j.wneu.2020.05.059DOI Listing

Clinical Features of Painful Ophthalmoplegia with a High-Intensity Ring Appearance around the Optic Nerve on MRI: A Case Series.

Case Rep Neurol Med 2020 30;2020:6737018. Epub 2020 Mar 30.

Department of Neurology, Toyohashi Municipal Hospital, Toyohashi, Japan.

Objective: Painful ophthalmoplegia includes nonspecific magnetic resonance imaging (MRI) manifestations and various clinical features including orbital pain and cranial nerve palsies. Treatment for painful ophthalmoplegia remains controversial. The aim of this report was to describe detailed clinical features, MRI findings, treatments, and prognosis of patients with painful ophthalmoplegia. Read More

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http://dx.doi.org/10.1155/2020/6737018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7149416PMC

Tolosa-Hunt Syndrome: Long-Term Outcome and Role of Steroid-Sparing Agents.

Ann Indian Acad Neurol 2020 Mar-Apr;23(2):201-205. Epub 2020 Feb 25.

Department of Neurological Sciences, Neurology Unit, Christian Medical College and Hospital, Vellore, Tamil Nadu, India.

Background: Tolosa-Hunt Syndrome (THS) is one of the causes of cavernous sinus syndrome causing painful ophthalmoplegia. Literature on long-term outcome of this rare condition is scarce.

Aims And Objectives: The aim is to study the recurrence and role of steroid-sparing agents in THS. Read More

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http://dx.doi.org/10.4103/aian.AIAN_368_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7061504PMC
February 2020
0.514 Impact Factor

Gradenigo's Syndrome with Carotid Septic Stenosis.

Case Rep Otolaryngol 2020 19;2020:9439184. Epub 2020 Feb 19.

Department of Otorhinolaryngology-Head and Neck Surgery, Hospital de Braga, Braga, Portugal.

Gradenigo's syndrome was firstly described in 1907 by Giusseppe Gradenigo and is defined as the clinical triad of suppurative otitis media, ipsilateral abducens nerve palsy, and pain in the distribution of the first and the second branches of the trigeminal nerve. Since the advent of antibiotics, the incidence of this potentially life-threatening complication has diminished, but occasional cases still occur. We herein report a pediatric case of otitis media associated with Gradenigo's syndrome complicated by ipsilateral septic cavernous sinus thrombosis and infectious arteritis of the internal carotid artery. Read More

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http://dx.doi.org/10.1155/2020/9439184DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7053453PMC
February 2020

Pituitary Apoplexy Accompanying Temporal Lobe Seizure as a Complication.

World Neurosurg 2020 Jun 5;138:153-157. Epub 2020 Mar 5.

Department of Neurological Surgery, Nihon University School of Medicine, Tokyo, Japan. Electronic address:

Background: Pituitary apoplexy is an acute clinical syndrome caused by infarction and/or hemorrhage of pituitary adenoma, which typically presents with severe headache, visual deterioration, and endocrine abnormalities. However, temporal lobe seizure (and temporal lobe epilepsy) has not been viewed as a symptom of pituitary apoplexy in the literature.

Case Description: To elucidate further such a rare complication of temporal lobe seizure, we describe here the rare clinical manifestations of a 55-year-old previously healthy man with pituitary apoplexy harboring headache, combined palsies involving cranial nerves III to VI, endocrinologic disturbances, and temporal lobe seizure. Read More

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http://dx.doi.org/10.1016/j.wneu.2020.02.148DOI Listing

Cavernous sinus thrombosis caused by -associated Lemierre syndrome presenting as an isolated abducens nerve palsy.

Am J Ophthalmol Case Rep 2020 Jun 7;18:100592. Epub 2020 Jan 7.

University of Missouri - Kansas City School of Medicine, 2411, Holmes St, Kansas City, MO, USA.

Purpose: To describe a patient with -associated Lemierre syndrome complicated by eventual cavernous sinus thrombosis (CST) that manifested as an isolated abducens nerve palsy.

Observations: A patient with a history of heavy alcohol use presented with Lemierre syndrome caused by an odontogenic infection due to . Despite initiation of intravenous antibiotics and eventual eradication of her bacteremia, she developed an isolated abducens nerve palsy on hospital day 7 due to associated CST. Read More

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http://dx.doi.org/10.1016/j.ajoc.2020.100592DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7037586PMC

Ectopic Cushing's syndrome in a patient with inferior petrosal sinus sampling indicating pituitary-dependent ACTH secretion.

Clin Case Rep 2020 Jan 14;8(1):104-107. Epub 2019 Dec 14.

Department of Internal Medicine III Division of Endocrinology and Metabolism Medical University Vienna Vienna Austria.

In an unclear case of Cushing's syndrome, IPSS identifies the origin of ACTH secretion, and together with MRI enables the localization of an ectopic corticotroph adenoma in the parasellar or cavernous sinuses region. Read More

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http://dx.doi.org/10.1002/ccr3.2586DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6982514PMC
January 2020

Management of Orbital Masses: Outcomes of Endoscopic and Combined Approaches With No Orbital Reconstruction.

Allergy Rhinol (Providence) 2020 Jan-Dec;11:2152656719899922. Epub 2020 Jan 14.

Department of Otolaryngology-Head and Neck Surgery, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania.

Introduction: The endoscopic endonasal approach to management of orbital pathology has expanded. Due to the rarity of these conditions, most reports in the literature consist of small case reports. We report a series from a single institution with a focus on outcomes. Read More

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http://dx.doi.org/10.1177/2152656719899922DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6961138PMC
January 2020

Metastatic Malignant Melanoma to the Cavernous Sinus: A Case of Recurrent Disease Presenting as Parkinson Syndrome.

J Neuroophthalmol 2020 Jan 14. Epub 2020 Jan 14.

Department of Ophthalmology (SCD, BNT, RBP, LCD), Hamilton Eye Institute, University of Tennessee Health Science Center, Memphis, Tennessee; Sanford School of Medicine (JJK), University of South Dakota, Vermillion, South Dakota; Department of Radiology (AFC), Le Bonheur Children's Hospital, Memphis, Tennessee; and Department of Ophthalmology (LCD), Le Bonheur Children's Hospital, Memphis, Tennessee.

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http://dx.doi.org/10.1097/WNO.0000000000000886DOI Listing
January 2020

FOLLICLE-STIMULATING HORMONE-PRODUCING PITUITARY ADENOMA: A CASE REPORT AND REVIEW OF THE LITERATURE.

AACE Clin Case Rep 2019 May-Jun;5(3):e175-e180. Epub 2019 Apr 25.

Objective: To describe an unusual presentation of a follicle-stimulating hormone-secreting pituitary adenoma leading to ovarian hyperstimulation syndrome. We also discuss the pathophysiology and subsequent management of these tumors.

Methods: This is a case report and review of the literature. Read More

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http://dx.doi.org/10.4158/ACCR-2018-0454DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6876947PMC

Persistent Bilateral Mydriasis Associated With a Pituitary Adenoma in a Horse.

J Equine Vet Sci 2020 Feb 23;85:102872. Epub 2019 Nov 23.

Department of Pathology, University of Veterinary Medicine, Hannover, Foundation, Hannover, Germany. Electronic address:

Severe bilateral mydriasis and bilaterally decreased vision were observed in a 23-year-old crossbred warmblood gelding with a history of pituitary pars intermedia dysfunction. Ten years after the onset of clinical signs, it was killed humanely because of worsening of clinical signs and loss of therapeutic responsiveness. Postmortem examination of the head was performed to confirm the suspected pituitary neoplasm and to investigate secondary oculomotor lesions. Read More

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http://dx.doi.org/10.1016/j.jevs.2019.102872DOI Listing
February 2020

External jugular venous sampling for Cushing's disease in a patient with hypoplastic inferior petrosal sinuses.

J Neurosurg 2020 Jan 17:1-4. Epub 2020 Jan 17.

1Department of Neurosurgery, Wake Forest University School of Medicine; and.

The authors report the case of a 30-year-old female patient with suspected Cushing's disease with an anatomical variation of hypoplastic inferior petrosal sinuses and nearly exclusive anterior drainage from the cavernous sinus, who underwent external jugular venous blood sampling with successful disease confirmation and microadenoma localization. The patient presented with signs and symptoms consistent with Cushing's syndrome, but with discordant preliminary diagnostic testing. She underwent attempted bilateral inferior petrosal sinus sampling; however, she had hypoplastic inferior petrosal sinuses bilaterally and predominantly anterior drainage from the cavernous sinus into the external jugular circulation. Read More

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http://dx.doi.org/10.3171/2019.11.JNS192374DOI Listing
January 2020

Cerebrofacial venous metameric syndrome-spectrum of imaging findings.

Neuroradiology 2020 Apr 14;62(4):417-425. Epub 2020 Jan 14.

Division of Neuroradiology, Joint Department of Medical Imaging, Toronto Western Hospital, UHN, University of Toronto, Toronto, Ontario, Canada.

Cerebrofacial venous metameric syndrome (CVMS) is a complex craniofacial vascular malformation disorder in which patients have a constellation of venous vascular malformations affecting soft tissues, bone, dura, and neural structures including the eye and brain. It is hypothesized that a somatic mutation responsible for the venous abnormalities occurred prior to migration of the neural crest cells, and because of this, facial, osseous, and cerebral involvement typically follows a segmental or "metameric" distribution. The most commonly recognized form of CVMS is Sturge-Weber syndrome. Read More

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http://dx.doi.org/10.1007/s00234-020-02362-7DOI Listing

The importance of landmarks in endoscopic endonasal reinterventions: the transpterygoid transcavernous approach.

Acta Neurochir (Wien) 2020 04 7;162(4):875-880. Epub 2020 Jan 7.

Department of Neurological Surgery, The Ohio State University, Wexner Medical Center, 410 W. 10th Ave., N-1049 Doan Hall, Columbus, OH, 43210, USA.

Background: Sellar and parasellar regions are anatomically complex region and in close relationship with important neurovascular structures. Hence, surgical treatment of recurrent aggressive pituitary adenomas invading the cavernous sinus represents an operative challenge, given the lack of landmarks that are missed because of the scar tissue and previous interventions.

Methods: We describe in detail the surgical technique of the transpterygoid transcavernous approach (TPTCa) for the surgical re-operation of a recurrent pituitary adenoma invading the left cavernous sinus in the context of a Nelson syndrome after bilateral adrenalectomy. Read More

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http://dx.doi.org/10.1007/s00701-019-04206-7DOI Listing
April 2020
1.788 Impact Factor

Gone in the blink of an eye - A Tolosa-Hunt syndrome variant.

J Clin Neurosci 2020 Feb 24;72:458-460. Epub 2019 Dec 24.

Wexham Park Hospital, Frimley Health NHS Foundation Trust, Internal Medicine, Berkshire, UK; University of Cyprus Medical School, Cardiology, Nicosia, Cyprus. Electronic address:

Tolosa-Hunt syndrome is a rare disorder characterized by severe peri-orbital headache and ophthalmoplegia resulting from pseudotumour in the cavernous sinus compressing structures within it, namely cranial nerves III, IV, and VI and the superior divisions of cranial nerve V. We report the case of a 47 year old female who presented with painless left unilateral ptosis and complete external ophthalmoplegia. Magnetic Resonance Imaging (MRI) identified an enhancing heterogeneous mass filling the left cavernous sinus, following the course of the oculomotor nerve. Read More

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http://dx.doi.org/10.1016/j.jocn.2019.12.037DOI Listing
February 2020

Orbital Apex Syndrome: A Review.

Eye Brain 2019 12;11:63-72. Epub 2019 Dec 12.

Department of Ophthalmology, Children's Hospital of Pittsburgh, University of Pittsburgh Medical Center, UPMC Eye Center, Pittsburgh, PA 15224, USA.

Orbital apex syndrome is characterized by vision loss from optic neuropathy and ophthalmoplegia due to the involvement of ocular motor nerves in the anatomical region of the orbital apex. Patients could present with signs and symptoms deriving from the involvement of structures within the orbital apex, the superior orbital fissure or the cavernous sinus. The primary focus of the ophthalmologist should be to locate the lesion and then identify its etiology. Read More

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http://dx.doi.org/10.2147/EB.S180190DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6913296PMC
December 2019

[Cavernous sinus syndrome secondary to thrombophlebitis due to Streptococcus intermedius complicated with vasculitis of the internal carotid artery and brain abscesses].

Rev Neurol 2020 Jan;70(1):19-22

Hospitals Vall d'Hebron, 08035 Barcelona, España.

Introduction: Thrombophlebitis of the cavernous sinus is a severe infectious disease with high mortality and morbidity. It is usually diagnosed at a late stage and requires a number of visits to the emergency department in most cases, and the prognosis is highly dependent on prompt treatment. Despite its severity, evidence regarding treatment with corticosteroids and anticoagulation therapy is scarce and controversial. Read More

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http://dx.doi.org/10.33588/rn.7001.2019376DOI Listing
January 2020

Manifestations of Skull Base IgG4-Related Disease: A Multi-Institutional Study.

Laryngoscope 2019 Dec 16. Epub 2019 Dec 16.

Department of Otolaryngology-Head and Neck Surgery, Mayo Clinic, Rochester, Minnesota, U.S.A.

Objective: IgG4-related disease (IgG4-RD) is a recently recognized disease characterized by fibroinflammatory infiltrates rich in IgG4+ plasma cells that can present as isolated tumor-like lesions of the head and neck. The objective of the current study was to describe the cranial base manifestations of IgG4-RD.

Methods: Review of all cases at three tertiary-referral centers since disease description in 2003. Read More

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http://dx.doi.org/10.1002/lary.28478DOI Listing
December 2019

A Case of Tolosa-Hunt Syndrome With Discoid Lupus Erythematosus.

Neurohospitalist 2020 Jan 6;10(1):48-50. Epub 2019 Mar 6.

Department of Neurosciences, New York Presbyterian Brooklyn Methodist Hospital, Brooklyn, NY, USA.

The occurrence of Tolosa-Hunt syndrome (THS) in the setting of discoid lupus erythematosus (DLE) has not been previously reported. We report a case of a 55-year-old Chinese man with established cutaneous lupus who presented with 1 week of worsening blurry vision and ptosis of the left eye with severe headache 2 weeks prior to presentation. His cranial nerve examination was significant for left afferent pupillary defect, red desaturation, ptosis, and oculomotor nerve palsy. Read More

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http://dx.doi.org/10.1177/1941874419828603DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6900659PMC
January 2020

Long-term follow-up for ectopic ACTH-secreting pituitary adenoma in a single tertiary medical center and a literature review.

Pituitary 2020 Apr;23(2):149-159

Key Laboratory of Endocrinology of National Health Commission, Department of Endocrinology, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, 100730, China.

Background: Ectopic ACTH-secreting pituitary adenoma (EAPA) are a rare cause of Cushing's disease. Due to the lack of consensus and experience in terms of the diagnosis and treatment of EAPAs, preoperative identification and optimal treatment remain challenging.

Purpose: To investigate the characteristics of EAPAs and offer some proposals for the diagnosis and management of this uncommon disease, the EAPA patients admitted to our center and all of the EAPA cases reported in the literature were reviewed. Read More

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http://dx.doi.org/10.1007/s11102-019-01017-yDOI Listing
April 2020
2.222 Impact Factor

Successful treatment of pediatric Tolosa-Hunt syndrome with adalimumab.

Eur J Rheumatol 2019 Dec 3:1-3. Epub 2019 Dec 3.

Department of Pediatrics, University of Alabama, Birmingham, Alabama, USA.

Objective: Tolosa-Hunt syndrome (THS) is a rare disease characterized by painful unliteral ophthalmoplegia and headache. THS is caused by granulomatous inflammation of the cavernous sinus, and its diagnosis is typically made by elimination and exclusion. The characteristic pain can typically be managed with steroid therapy, but relapses are common. Read More

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http://dx.doi.org/10.5152/eurjrheum.2019.19149DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7004262PMC
December 2019

Fourth Nerve Paresis and Ipsilateral Horner's Syndrome: An Unusual Association.

Authors:
Roberto Ebner

Neuroophthalmology 2019 Nov 11;43(5):289-290. Epub 2019 Jan 11.

Chairman of Ophthalmology, Hospital Británico de Buenos Aires, Buenos Aires, Argentina.

Presence of a fourth nerve palsy and ipsilateral Horner's Syndrome (HS) is an exceptional association. A case of a 54 year-old patient with diplopia due to a fourth nerve palsy and acquired HS on the same is presented along with magnetic resonance images (MRI) revealing a mass in the right cavernous sinus. This new combination of ipsilateral signs is analyzed. Read More

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http://dx.doi.org/10.1080/01658107.2018.1562475DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6844520PMC
November 2019

Sixth nerve palsy in sporadic Burkitt Lymphoma.

Am J Ophthalmol Case Rep 2019 Dec 31;16:100565. Epub 2019 Oct 31.

School of Medicine (SY), (Department of Ophthalmology (AGL), Baylor College of Medicine, 1 Baylor Plaza, Houston, TX, 77030, USA.

Purpose: To describe a unique presentation of Central Nervous System Burkitt Lymphoma.

Observations: A 59-year-old male presented with new onset binocular horizontal diplopia five days after initial presentation with abdominal distension, weight loss, and night sweats. He was diagnosed with Burkitt Lymphoma with base of skull metastasis that was initially visible only on PET scan and subsequently resolved with chemotherapy. Read More

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http://dx.doi.org/10.1016/j.ajoc.2019.100565DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6849134PMC
December 2019

Peripheral cranial neuropathies consistent with cavernous sinus syndrome caused by extracranial nasopharyngeal lymphoma in a cat.

Can Vet J 2019 Nov;60(11):1156-1160

Department of Small Animal Clinical Science, Western College of Veterinary Medicine, University of Saskatchewan, 52 Campus Drive, Saskatoon, Saskatchewan S7N 5B4.

Cavernous sinus syndrome is a unique constellation of cranial nerve deficits occurring typically as a result of pathologic infiltration of the cavernous sinus, which is located in the lateral sellar compartment of the calvarium. This case report describes a polyneuropathy consistent with cavernous sinus syndrome as a result of a lesion outside of the cavernous sinus. The cat was presented with right internal and external ophthalmoplegia, loss of right corneal sensation, inspiratory stridor, dysphagia, dysphonia, tongue weakness, and weight loss. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6805027PMC
November 2019
1 Read

Reappraising the Tolosa-Hunt Syndrome Diagnostic Criteria: A Case Series.

Headache 2020 Jan 4;60(1):259-264. Epub 2019 Nov 4.

Department of Neurosurgery, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Introduction: Tolosa-Hunt syndrome (THS), a condition characterized by painful ophthalmoplegia and accompanied by cranial nerve palsies, remains as a diagnosis of exclusion. Nevertheless, the 3rd Edition of the International Classification of Headache Disorders (ICHD) has refined its diagnostic criteria to require the demonstration of granulomatous inflammation on magnetic resonance imaging or biopsy. We sought to assess the effectiveness of the new criteria in arriving at accurate diagnoses. Read More

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http://dx.doi.org/10.1111/head.13692DOI Listing
January 2020

[Internal Carotid Artery-Cavernous Sinus Fistula in a Patient with Masked Hypertension Caused by Bilateral Subclavian Artery Stenosis:A Case Report].

No Shinkei Geka 2019 Oct;47(10):1065-1072

Department of Neuroendovascular Treatment, JCHO Tokyo Shinjuku Medical Center.

We herein report a case of direct carotid-cavernous fistula(direct CCF)in a patient with masked hypertension caused by bilateral subclavian artery stenosis. A 74-year-old woman presented with headache, right-sided proptosis, double vision, and pulsatile tinnitus since past 10 days. The patient was diagnosed with direct CCF. Read More

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http://dx.doi.org/10.11477/mf.1436204075DOI Listing
October 2019

Rathke's Cleft Cyst Apoplexy in Two Teenage Sisters.

Pediatr Neurosurg 2019 21;54(6):428-435. Epub 2019 Oct 21.

Department of Neurosurgery, Medical University of South Carolina (MUSC), Charleston, South Carolina, USA,

Rathke's cleft cysts (RCC) are sellar-suprasellar cysts that are usually discovered incidentally given their indolent clinical course. When symptoms do arise, the most common clinical presentation is headache, visual field deficits due to visual pathway compression, diplopia due to cavernous sinus compression, chemical meningitis due to spillage of the cyst contents, endocrine dysfunction, and very rarely apoplexy. We present 2 cases of RCC in sisters who developed a sudden onset of symptoms in a manner similar to pituitary apoplexy. Read More

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http://dx.doi.org/10.1159/000503112DOI Listing

Nasopharyngeal carcinoma presenting as a sixth nerve palsy and Horner's syndrome.

BMJ Case Rep 2019 Oct 10;12(10). Epub 2019 Oct 10.

Department of Ophthalmology and Vision Sciences, University of Toronto, Toronto, Ontario, Canada

The combination of a sixth nerve palsy and ipsilateral Horner's syndrome localises the disease process to the posterior cavernous sinus and can be a result of various pathologies in this region. A 74-year-old Chinese woman presented with a 9-month history of binocular horizontal diplopia worse when looking left. She was found to have a left sixth nerve palsy and Horner's syndrome and MRI revealed an enhancing soft tissue mass in the nasopharynx with involvement of the bones of the skull base and invasion of the left cavernous sinus. Read More

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http://dx.doi.org/10.1136/bcr-2019-232291DOI Listing
October 2019
1 Read

Behcet's-like syndrome following pembrolizumab: An immune-related adverse event associated with programmed death receptor-1 inhibitor therapy.

J Oncol Pharm Pract 2020 Jun 1;26(4):995-999. Epub 2019 Oct 1.

Department of Rheumatology, University of Connecticut, Farmington, USA.

Introduction: The landscape for the treatment of metastatic melanoma has been revolutionized with the introduction immune checkpoint inhibitors. Immune checkpoint inhibitors have now become the standard of care for the treatment of cancers. These immune agents including programmed death receptor-1 inhibitors, programmed death-ligand 1 inhibitors and cytotoxic T-lymphocyte antigen-4 inhibitors have shown promising results but have been associated with numerous immune-related complications. Read More

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http://dx.doi.org/10.1177/1078155219877219DOI Listing
June 2020
2 Reads

Horner Syndrome as Complication of Acute Sphenoid Sinusitis.

Case Rep Neurol 2019 Jan-Apr;11(1):112-116. Epub 2019 Apr 4.

Department of Otorhinolaryngology, Head and Neck Surgery, Inselspital, Bern University Hospital, Bern, Switzerland.

Horner syndrome is described in this case report as a rare complication of bacterial sphenoid sinusitis. A patient presented with miosis, ptosis, and ophthalmic nerve palsy with acute sphenoid sinusistis and cavernous sinus thrombosis on MRI. The impairment of sympathetic fiberscan can be explained through the direct septic effects of the sphenoid sinusitis and indirectly through thrombosis of the cavernous sinus at the level of the carotid plexus. Read More

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http://dx.doi.org/10.1159/000497742DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6739703PMC
April 2019
2 Reads

[Cavernous sinus syndrome as the initial symptom of Burkitt's lymphoma: a case report and literature review].

Rev Neurol 2019 Sep;69(6):249-254

Hospital Universitario 12 de Octubre, Madrid, Espana.

Introduction: The cavernous sinus is a structure in the base of the skull that houses several nerve and vascular structures. Its compromise leads to cavernous sinus syndrome, which is a combination of oculomotor disorders and others affecting the first two trigeminal branches, often accompanied by pain or proptosis. Infiltration due to Burkitt's lymphoma is a rare cause of this syndrome. Read More

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http://dx.doi.org/10.33588/rn.6906.2019191DOI Listing
September 2019
1 Read

Rathke's cleft cyst presenting as incomplete cavernous sinus syndrome and disc edema: a case report with literature review.

Doc Ophthalmol 2020 02 6;140(1):55-65. Epub 2019 Sep 6.

Department of Neurology, Fu Jen Catholic University Hospital, Fu Jen Catholic University, New Taipei City, Taiwan, ROC.

Purpose: To report a Rathke's cleft cyst (RCC) presenting as unilateral incomplete cavernous sinus syndrome and disc edema METHOD: Case report with literature review RESULTS: We present an 18-year-old girl who has been experiencing intermittent binocular diplopia for 1 month. Upon examination, the best corrected visual acuity was 20/20 (OU). Pronounced limitation of ocular motility with ptosis in her right eye was noted. Read More

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http://dx.doi.org/10.1007/s10633-019-09713-7DOI Listing
February 2020
2 Reads

Central Diabetes Insipidus Associated with Orbital Apex Syndrome.

J Nippon Med Sch 2019 ;86(4):254-257

Department of Internal Medicine, Chonnam National University Medical School.

Orbital apex syndrome (OAS) manifests as multiple cranial nerve palsies caused by an abnormal nerve response to inflammation or other processes. Central diabetes insipidus (CDI) is characterized by deficient synthesis or secretion of antidiuretic hormone. A 62-year-old woman underwent myringotomy for otitis media with effusion. Read More

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http://dx.doi.org/10.1272/jnms.JNMS.2019_86-409DOI Listing
February 2020
2 Reads

Bilateral Cavernous Sinus Syndrome, Pituitary Macroadenoma, and Postoperative Loss of Vision: A Case Report.

A A Pract 2019 Nov;13(9):350-351

From the Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, Minnesota.

Postoperative vision loss is a rare complication. When visual loss does occur, it is rarely associated with ophthalmoplegia. We report a case of postoperative bilateral visual field deficits with concomitant complete bilateral ophthalmoplegia in a patient with a known pituitary macroadenoma after surgical excision of a small cell carcinoma of the bladder. Read More

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http://dx.doi.org/10.1213/XAA.0000000000001083DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6819024PMC
November 2019
2 Reads

Predictors of the Resolution of Cavernous Sinus Syndrome Caused by Large/Giant Cavernous Carotid Aneurysms After Parent Artery Occlusion with High-Flow Bypass.

World Neurosurg 2019 Dec 20;132:e637-e644. Epub 2019 Aug 20.

Department of Cerebrovascular Surgery, Saitama Medical University International Medical Center, Saitama, Japan.

Objective: To evaluate the clinical results and factors related to the resolution of preoperative cranial neuropathy after internal carotid artery ligation with high-flow bypass in patients with symptomatic large or giant cavernous carotid aneurysms.

Methods: This study included 18 consecutive patients (15 women) with cranial neuropathy. All patients underwent therapeutic internal carotid artery ligation with high-flow bypass using a radial artery graft. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18788750193221
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http://dx.doi.org/10.1016/j.wneu.2019.08.059DOI Listing
December 2019
1 Read

Predictive modeling for pituitary adenomas: single center experience in 501 consecutive patients.

Pituitary 2019 Oct;22(5):520-531

Division of Endocrinology, Metabolism and Lipids, Department of Medicine, Emory University School of Medicine, 1364 Clifton Road NE, Atlanta, GA, 30322, USA.

Background: Personalized postoperative management of patients with pituitary adenomas requires an early risk stratification system.

Methods: We reviewed 501 cases operated between 10/27/2011 and 5/5/2016 by a single neurosurgeon. We determined biochemical remission and tumor resection at 3 months, and biochemical recurrence, tumor recurrence, radiation and reoperation during follow-up. Read More

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http://dx.doi.org/10.1007/s11102-019-00982-8DOI Listing
October 2019
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Orbital Compartment Syndrome Secondary to Direct Carotid Cavernous Fistula After Carotid Cavernous Aneurysm Rupture: Case Report and Review of Literature.

World Neurosurg 2020 Jan 14;133:409-412. Epub 2019 Aug 14.

Division of Vascular and Endovascular Neurosurgery, Firoozgar Hospital, Tehran, Iran; Neuroscience Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address:

Background: Carotid cavernous aneurysm (CCA) rupture is rare. However, it can result in various complications such as carotid cavernous fistula (CCF), epistaxis, spontaneous thrombosis, and subarachnoid hemorrhage.

Case Description: We report a 65-year-old woman with a history of uncontrolled diabetes who was referred with complaints of acute headache, diplopia, proptosis, and chemosis. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.08.037DOI Listing
January 2020
5 Reads

Dural sinus malformation with giant pouch (DSMGP): symptoms and treatment.

Childs Nerv Syst 2020 02 8;36(2):343-348. Epub 2019 Aug 8.

Department of Neurosurgery, Hospital Nacional de Pediatria JP Garrahan, Combate de los Pozos 1881, 1254, Buenos Aires, Argentina.

Objective: The aim of this study is to describe the clinical manifestations and treatment options of patients having dural sinus malformation with giant pouch (DSMGP) in a tertiary pediatric center.

Introduction: Dural sinus malformation with giant pouch (DSMGP) is a rare vascular malformation affecting fetuses, newborns, and infants. It is characterized by a dilated dural sinus frequently thrombosed with arteriovenous fistula (AVF) in its wall. Read More

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http://dx.doi.org/10.1007/s00381-019-04338-2DOI Listing
February 2020
3 Reads

The clinical characteristics, implicated pathogens and therapeutic outcomes of culture-proven septic cavernous sinus thrombosis.

J Clin Neurosci 2019 Oct 19;68:111-116. Epub 2019 Jul 19.

Department of Neurology, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung, Taiwan. Electronic address:

In this magnetic resonance imaging-based study, we investigated the clinical features, neuroimaging features and therapeutic outcomes of 14 adults (eight men and six women; mean age 60.4 years; range 37-77 years) with septic cavernous sinus thrombosis (CST). Of the underlying conditions, 10 had diabetes mellitus and 13 had concomitant sphenoid sinusitis. Read More

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http://dx.doi.org/10.1016/j.jocn.2019.07.022DOI Listing
October 2019
6 Reads

Diffuse Infiltration of Multiple Myeloma With Initial Manifestation of Cavernous Sinus Syndrome Unveiled by 18F-FDG PET/CT.

Clin Nucl Med 2019 Sep;44(9):746-747

From the Department of Nuclear Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology.

Intracranial infiltration is a rare complication of multiple myeloma (MM), which is usually seen in advanced stage. Here, we report a 47-year-old woman with only cavernous sinus syndrome as first manifestation. Brain MR revealed cavernous sinus masses, leptomeningeal nodules, and osseous erosion, which were considered metastases. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002722DOI Listing
September 2019
2 Reads

Gamma Knife radiosurgery for the treatment of Nelson's syndrome: a multicenter, international study.

J Neurosurg 2019 Jul 12:1-6. Epub 2019 Jul 12.

1Department of Neurological Surgery, University of Virginia Health System, Charlottesville, Virginia.

Objective: Nelson's syndrome is a rare and challenging neuroendocrine disorder, and it is associated with elevated adrenocorticotrophic hormone (ACTH) level, skin hyperpigmentation, and pituitary adenoma growth. Management options including resection and medical therapy are traditional approaches. Ionizing radiation in the form of Gamma Knife radiosurgery (GKRS) is also being utilized to treat Nelson's syndrome. Read More

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http://dx.doi.org/10.3171/2019.4.JNS19273DOI Listing
July 2019
6 Reads

When the Problem Became the Solution.

Can J Neurol Sci 2019 11;46(6):767-769

Department of Ophthalmology and Vision Sciences, University of Toronto, Toronto, Ontario, Canada.

We present a unique case where a young man developed subtle cavernous sinus thrombosis (CST) due to underlying hypercoagulable state. He also had coexisting frontal lobe brain dural arteriovenous fistula (bdAVF). After CST developed, venous drainage from the optic nerve was redirected into the frontal lobe which was already under high venous pressure because of preexisting bdAVF. Read More

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http://dx.doi.org/10.1017/cjn.2019.239DOI Listing
November 2019
1 Read

[Clinical analysis of 8 cases with anti-GQ1b antibody syndrome].

Zhonghua Yi Xue Za Zhi 2019 Jun;99(23):1800-1804

Department of Neurology, Nanjing Brain Hospital Affiliated to Nanjing Medical University, Nanjing 210012, China.

To investigate the clinical characterization, treatment and prognosis of anti-GQ1b antibody syndrome. The clinical data of 8 patients with positive serum anti-GQ1b antibody from the Department of Neurology of Nanjing Brain Hospital between June 2016 and July 2018 were analyzed retrospectively. Their serums were tested by immunoblotting. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0376-2491.2019.23.010DOI Listing
June 2019
15 Reads

Management of two cavernous sinus dural arteriovenous fistulae by direct microsurgical approach and catheterization of the superior ophthalmic vein.

Neurochirurgie 2019 Dec 14;65(6):397-401. Epub 2019 Jun 14.

Department of Neurosurgery, La Timone Hospital, Assistance Publique - Hôpitaux de Marseille, 13385 Provence-Alpes-Côte d'Azur, France. Electronic address:

Background: In case of cavernous sinus dural arteriovenous fistula, transvenous embolization of the cavernous sinus via the inferior petrosal sinus is generally sufficient. However, when inferior petrosal sinus access is challenging, various alternative approaches have been reported, with corresponding difficulties and risks.

Case Reports: We report the management of two cases of life-threatening cavernous sinus dural arteriovenous fistula revealed by a typical cavernous sinus syndrome. Read More

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http://dx.doi.org/10.1016/j.neuchi.2019.05.005DOI Listing
December 2019
13 Reads

Mediastinitis as complication of odontogenic infection: A case report.

Niger J Clin Pract 2019 Jun;22(6):869-871

Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Gaziosmanpasa University, Tokat, Turkey.

Odontogenic infections are one of the most common dental problems, which affect 80%-90% of the population. Untreated odontogenic infections can cause life-threatening complications such as necrotizing fasciitis, descending necrotizing mediastinitis, internal jugular vein thrombosis, cavernous sinus thrombosis, carotid artery pseudoaneurysm or rupture, and systemic inflammatory response syndrome. This report aims to present a mediastinitis case, in a 22-year-old healthy male patient, which originated from an odontogenic infection. Read More

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http://dx.doi.org/10.4103/njcp.njcp_539_18DOI Listing
June 2019
16 Reads

Mycotic Aneurysm of Intracavernous Internal Carotid Artery Presenting as Cavernous Sinus Syndrome.

Asian J Neurosurg 2019 Apr-Jun;14(2):547-549

Department of Ophthalmology, Sanjay Gandhi Postgraduate Institution of Medical Sciences, Lucknow, Uttar Pradesh, India.

Mycotic intracranial aneurysms are infectious aneurysms accounting for 0.7%-6.5% of all intracranial aneurysms and are most commonly located in distal branches of the middle cerebral arteries, particularly at the bifurcation area. Read More

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http://dx.doi.org/10.4103/ajns.AJNS_39_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6515997PMC
May 2019
8 Reads