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Emerg Infect Dis 2020 Jul;26(7):1438-1446

Atypical manifestations that can be severe and difficult to diagnosis develop in 5%-20% of patients with cat-scratch disease. To clarify the epidemiology of atypical cat-scratch disease in the United States, we analyzed data from the 2005-2014 MarketScan national health insurance claims databases by using the International Classification of Diseases, 9th Revision, Clinical Modification, codes for cat-scratch disease and selected atypical manifestations: retinitis/neuroretinitis, conjunctivitis, neuritis, encephalitis, hepatosplenic disease, osteomyelitis, erythema nodosum, and endocarditis. Atypical cat-scratch disease accounted for 1. Read More

Radiol Case Rep 2020 Aug 9;15(8):1180-1183. Epub 2020 Jun 9.

State University of New York Upstate Medical University, Department of Radiology, 750 East Adams Street, Syracuse, NY, 13210, USA.

Cat scratch disease is an infection caused by Bartonella Henselae with characteristic presentation of lymphadenopathy. Despite self-limited nature of the disease in most cases, it accounts for many lymph node biopsies performed since its imaging features can mimic lymphoma in appearance, thus requiring additional invasive procedures. Lack of restricted diffusion may be helpful in distinguishing imaging feature of reactive lymph nodes with caseating necrosis seen in cat scratch disease from lymphoma or abscess. Read More

Pract Neurol 2020 Jun 16. Epub 2020 Jun 16.

Department of Neurology, Beaumont Hospital, Dublin, Ireland.

We report a patient with cat-scratch disease presenting with meningitis and neuroretinitis. This condition, caused by has a worldwide distribution and is among the most common infective causes of neuroretinitis. Bartonella neuroretinitis is a rare but under-recognised mimic of optic neuritis; it should be suspected in a patient with an infective prodrome whose fundus shows optic disc oedema and a macular star. Read More

Ann Clin Microbiol Antimicrob 2020 Jun 9;19(1):28. Epub 2020 Jun 9.

Department of Intensive Care Unit, The First Affiliated Hospital of USTC, Division of Life Science and Medicine, University of Science and Technology of China, 17 Lujiang Road, Hefei, Anhui, China.

Background: Adult-onset hemophagocytic lymphohistiocytosis (HLH) is a rare and life-threatening condition, which is often triggered by certain types of infection, cancer and numerous autoimmune diseases; however, of the numerous infectious triggers associated with HLH, the consequences of Bartonella henselae infection have been rarely reported.

Case Presentation: A 48-year-old female presented with a 20-day history of intermittent fever accompanied by systemic rash, fatigue, anorexia and weight loss later she developed shock and unconsciousness. Blood tests showed a reduction of leukocyte, anemia and thrombocytopenia, and pathological results of a bone marrow biopsy confirmed hemophagocytic activity. Read More

Hawaii J Health Soc Welf 2020 May;79(5 Suppl 1):64-70

Department of Pediatrics, John A. Burns School of Medicine, University of Hawai'i at Mānoa, Honolulu, HI.

Cat scratch disease is known to be a generally benign, self-resolving illness associated with non-specific symptoms, including lymphadenopathy, fever, fatigue, anorexia, and headaches. However, it can also cause disseminated disease with a wide range of manifestations, including liver and spleen microabscesses, osteomyelitis, encephalitis, and uveitis. Eighteen pediatric cases of disseminated cat scratch disease at a single center in Hawai'i are described. Read More

Clin Imaging 2020 May 3;66:111-120. Epub 2020 May 3.

Department of Radiology, St Louis University School of Medicine, United States of America. Electronic address:

Breast malignancy is the second most common cause of cancer death in women. However, less common breast masses can mimic carcinoma and can pose diagnostic challenges. This case-based review describes a spectrum of rare breast neoplastic and non-neoplastic masses ranging from malignant to benign entities. Read More

Clin Microbiol Infect 2020 May 11. Epub 2020 May 11.

Division of Infectious Diseases and Hospital Epidemiology, University Children's Hospital Zurich, Zurich, Switzerland.

Am J Ophthalmol Case Rep 2020 Sep 6;19:100734. Epub 2020 May 6.

Retina Consultants of Alabama, P.C., USA.

Purpose: To summarize the case of a 13 year-old boy diagnosed with a BRAO secondary to infection.

Observations: The patient presented with a sudden, unilateral, and painless scotoma. Fundoscopic findings and multimodal imaging were consistent with a BRAO with associated areas of intraretinal whitening along the involved artery. Read More

J Clin Pharm Ther 2020 Aug 17;45(4):840-844. Epub 2020 May 17.

Unidad de Gestión Clínica Farmacia, Hospital Juan Ramón Jiménez, Huelva, Spain.

What Is Known And Objectives: Bartonella henselae is the etiologic agent of "cat scratch disease (CSD)". We describe a case of atypical CSD in a paediatric patient and include a review of the antibiotic treatment for this disease.

Case Description: A 2-year-old child, with convulsive status and loss of consciousness, was admitted to hospital. Read More

Pediatr Infect Dis J 2020 May 12. Epub 2020 May 12.

From the Center of Pediatric Infectious Diseases, Complejo Asistencial Dr. Sótero del Río, Santiago, Chile.

Background: Bartonella henselae is the etiologic agent of cat-scratch disease, which affects the entire world population. Due to how poorly characterized the child population is, the objective was to describe the clinical behavior of this disease in children younger than 16 years of age.

Methods: This was a descriptive study with prospective follow-up of all children younger than 16 years with clinical and serologic diagnoses between 2013 and 2018. Read More

Vet Ital 2020 Apr 24;56(1). Epub 2020 Apr 24.

Istituto Zooprofilattico Sperimentale dell'Abruzzo e del Molise "G. Caporale".

Cat scratch disease (CSD) is a zoonotic disease, caused predominantly by Bartonella henselae and transmitted to humans through a scratch or bite of the cat. Cat represents the principal reservoir and healthy carrier of Bartonella, which is mainly transmitted, among cats, by the flea Ctenocephalides felis. During 2014, fifty‑two samples of whole blood and sera were collected randomly from cats in Abruzzo region and were examined by real-time PCR and IFAT tests, respectively. Read More

Turk Arch Otorhinolaryngol 2020 Mar 26;58(1):48-51. Epub 2020 Mar 26.

Department of Otorhinolaryngology - Head and Neck Surgery, Hospital de Braga, Braga, Portugal.

Cat-scratch disease (CSD) is one of the most common causes of infectious cervicofacial lymphadenopathies in children, adolescents, and young adults. With this case report, we highlight the wide spectrum of atypical manifestations of CSD in an elderly patient who presented not only with cervicofacial lymphadenopathies but also parotid enlargement, and Parinaud's oculoglandular syndrome which comprises granulomatous nonsuppurative conjunctivitis with adjacent ipsilateral preauricular lymphadenopathy. A high index of suspicion is needed to correctly diagnose and treat this clinical entity. Read More

Vector Borne Zoonotic Dis 2020 Jul 8;20(7):529-534. Epub 2020 Apr 8.

Department of Parasitology and Zoology, University of Veterinary Medicine, Budapest, Hungary.

In a sanctuary located on the island of Malta, 23 clinically healthy cats randomly selected were sampled for blood and fleas. Only fleas were collected from 35 cats. All fleas were identified as , except for one specimen of . Read More

Eur Arch Otorhinolaryngol 2020 Jun 6;277(6):1785-1792. Epub 2020 Mar 6.

Institute of Experimental and Clinical Research (IREC), Catholic University of Louvain, Brussels, Belgium.

Purpose: Granulomatous inflammation is a common cause of subacute cervicofacial lymphadenitis in children. Nontuberculous mycobacterial (NTM) infections and cat-scratch disease (CSD) are the most frequent causes. Optimal treatment, which may include surgery, antibiotic treatment or wait-and-see approach, is debatable. Read More

Br J Ophthalmol 2020 Mar 2. Epub 2020 Mar 2.

NIHR Health Protection Research Unit in Healthcare Associated Infections and Antimicrobial Resistance, Imperial College London, London W12 0NN, UK

Cat scratch disease (CSD) in humans is caused by infection with or other spp. The name of the disease reflects the fact that patients frequently have a history of contact (often involving bites or scratches) with infected cats. Patients with CSD typically develop lesions at the site where the skin is broken together with regional lymphadenopathy but may go on to exhibit systemic symptoms and with deep-seated infections at a range of sites including the eye. Read More

Vet Parasitol Reg Stud Reports 2020 01 5;19:100361. Epub 2019 Dec 5.

Centro de Estudios Parasitológicos y de Vectores (CONICET-UNLP), Bv. 120 s/n e/ 60 y 64, 1900 La Plata, Argentina. Electronic address:

Molecular methods were used to detect and identify Bartonella species in the cat fleas Ctenocephalides felis felis from Puerto Iguazú, a border area in northeastern Argentina. The fleas were collected from 12 household animals, 9 dogs (Canis lupus familiaris) and 3 cats (Felis silvestris catus) during July 2016. Out of 15C. Read More

J Clin Rheumatol 2020 Feb 6. Epub 2020 Feb 6.

From the VA Northern California Health System Medical Center, Sacramento.

Pediatr Int 2020 Feb 3;62(2):242-244. Epub 2020 Feb 3.

Department of Pediatrics and Child Health, Nihon University School of Medicine, Tokyo, Japan.

Prague Med Rep 2019 ;120(4):131-137

Department of Medicine and Department of Neurology, Federal University of Santa Maria, Santa Maria, Brasil.

The GBS/ATM overlap is characterized by the simultaneous occurrence of Guillain-Barré syndrome (GBS) and acute transverse myelitis (ATM), which are two neurological autoimmune disorders. In this context, cat scratch disease (CSD) was rarely reported combined with this overlap. An adult female presenting fever, back pain, inferior limb weakness, and anuria was admitted to our hospital. Read More

Appl Immunohistochem Mol Morphol 2020 Jan 6. Epub 2020 Jan 6.

Department of Pathology, The Second Xiangya Hospital, Central South University.

Purpose: Cat scratch disease (CSD) is an infectious disorder caused primarily by the bacterium Bartonella henselae (B. henselae). Immunohistochemistry (IHC) and Warthin-Starry silver stain (WS) are considered to be indispensable to diagnose CSD in combination with morphologic characteristics. Read More

Klin Mikrobiol Infekc Lek 2019 Sep;25(3):84-88

Department Infectious Diseases, University Hospital, Ostrava-Poruba, Czech Republic,

Objective: The diagnosis of Bartonella henselae by polymerase chain reaction (PCR) in lymph nodes removed in 10 patients with serologically confirmed evidence cat-scratch disease.

Material And Methods: The 2015-2018 group consisted of 10 patients with serologically confirmed cat-scratch disease, all of them having positive IgG antibodies and 6 patients also positive IgM antibodies against B. henselae. Read More

Ann Agric Environ Med 2019 Dec 18;26(4):669-671. Epub 2019 Mar 18.

Faculty of Veterinary Medicine, University of Life Sciences, Lublin, Poland.

Bartonellosis is a disease affecting a variety of animals. Many Bartonella infections are zoonotic, including cat scratch disease. Within the genus Bartonella are 45 species, of which more than 10 can infect cats and dogs. Read More

Infez Med 2019 12;27(4):441-444

Department of Hospital Medicine, Mount Carmel East Hospital, Columbus, OH, USA.

Bartonella infection has been associated with culture negative endocarditis and in rare cases immune complex medicated rapidly progressive glomerulonephritis (RPGN). Most of the previously reported cases of RPGN are associated with endocarditis. We report a case of RPGN with no endocarditis secondary to Bartonella infection. Read More

JBJS Case Connect 2019 Dec;9(4):e0081

Department of Orthopaedics and Rehabilitation, University of Vermont, Burlington, Vermont.

Case: This is the first clinical report of periprosthetic total joint infection caused by Bartonella henselae. A 65-year-old woman developed an acutely painful total knee 3 weeks after a cat scratch. Serial joint aspirations and tissue cultures failed to identify any organism. Read More

Vet Q 2019 12;39(1):168-173

The Department of Pathology, School of Medicine, University of California, Irvine, CA, USA.

Antibiotics (Basel) 2019 Nov 30;8(4). Epub 2019 Nov 30.

Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA.

is a fastidious Gram-negative intracellular bacterium that can cause cat scratch disease, endocarditis in humans and animals, as well as other complications, leading to acute or chronic infections. The current treatment for infections is not very effective due to antibiotic resistance and also persistence. To develop better therapies for persistent and chronic infections, in this study, with the help of SYBR Green I/PI viability assay, we performed a high-throughput screening of an essential oil library against the stationary phase . Read More

An Bras Dermatol 2019 Sep - Oct;94(5):594-602. Epub 2019 Oct 2.

Laboratory of Applied Research in Dermatology and Bartonella Infection, School of Medical Sciences, Universidade Estadual de Campinas, Campinas, SP, Brazil; Discipline of Dermatology, Department of Clinical Medicine, School of Medical Sciences, Universidade Estadual de Campinas, Campinas, SP, Brazil. Electronic address:

Bartonellosis are diseases caused by any kind of Bartonella species. The infection manifests as asymptomatic bacteremia to potentially fatal disorders. Many species are pathogenic to humans, but three are responsible for most clinical symptoms: Bartonella bacilliformis, Bartonella quintana, and Bartonella henselae. Read More

Clin Infect Dis 2019 Nov 23. Epub 2019 Nov 23.

Infectious Disease Unit, Tel Aviv Sourasky Medical Center and the Sackler Faculty of Medicine, Tel Aviv university, Tel Aviv, Israel.

Background: Fever of unknown origin (FUO) is a rare manifestation of cat scratch disease (CSD). Data regarding CSD associated FUO (CSD-FUO), particularly in adults, are limited. We aimed to study disease manifestations and long-term clinical outcome. Read More

Indian J Med Microbiol 2019 Apr-Jun;37(2):292-295

Department of Microbiology, All India Institute of Medical Sciences, New Delhi, India.

To the best of our knowledge, this is the first case of multifocal hepatic abscesses in a young immunocompetent adult from India, which was successfully treated with hepatectomy and short course of oral antibiotic regimen. Publishing further such case reports will provide more clarity regarding the clinical significance of the disease, including associated risk factors and appropriate treatment. Read More

Cureus 2019 Aug 21;11(8):e5456. Epub 2019 Aug 21.

Emergency Medicine, Thomas Jefferson University, Philadelphia, USA.

Bartonella henselae is a relatively uncommon pathogen that can present as a serious disease in immunocompromised patients. We present a case of a 76-year-old man with stable chronic lymphocytic leukemia (CLL) who presented to the emergency department (ED) with an onset of right axillary lymphadenitis after recovering from a recent cat bite on the ipsilateral finger. Doppler ultrasound demonstrated an irregular, circumscribed 5cm x 4cm, hypoechoic mass with mild vascular flow consistent with an enlarged abnormal lymph node. Read More

BMC Oral Health 2019 10 21;19(1):223. Epub 2019 Oct 21.

Department of Oral Medicine, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, 310009, People's Republic of China.

Background: Kikuchi-Fujimoto disease, known as histiocytic necrotizing lymphadenitis, is a benign, self-limiting and systemic disorder involving lymph nodes with unknown aetiology. First reported in Japan, there has been an increase in its incidence globally. Because of its non-specific clinical features, the disease can be easily mistaken for other forms of lymphadenitis with a high rate of misdiagnosis and mistreatment, posing a considerable challenge. Read More

Breast J 2020 Apr 17;26(4):786-787. Epub 2019 Sep 17.

Geisel School of Medicine at Dartmouth, Hanover, NH, USA.

J Curr Ophthalmol 2019 Sep 6;31(3):254-261. Epub 2019 May 6.

Department of Ophthalmology, Fattouma Bourguiba University Hospital, Faculty of Medicine, University of Monastir, Monastir, Tunisia.

Purpose: To review the clinical features, diagnosis, treatment modalities, and prognosis of Bartonella-associated neuroretinitis.

Methods: This is a narrative review on Bartonella-associated neuroretinitis including general and ophthalmological aspects of the disease. A comprehensive literature review between January 1950 and September 2018 was conducted in PubMed database. Read More

Gastroenterology 2019 10 30;157(4):e10-e11. Epub 2019 May 30.

Department of Gastroenterology, and Laboratory of Translational Gastroenterology, Qilu Hospital of Shandong University, Jinan, Shandong, China.

J Clin Microbiol 2019 09 26;57(9). Epub 2019 Aug 26.

Division of Clinical Microbiology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA

Comp Immunol Microbiol Infect Dis 2019 Oct 9;66:101344. Epub 2019 Aug 9.

Faculty of Veterinary Medicine, Teaching Veterinary Hospital, University of Teramo, Teramo, Italy. Electronic address:

Zoonotic Vector-Borne Diseases (VBDs) represent a relevant health issue for pets and humans. Italy is a major epidemiological hub for feline VBDs, because of suitable conditions for vector biology and disease transmission patterns. The present study investigated the exposure to major zoonotic arthropod-borne pathogens of cats in Italy, along with the evaluation of clinic-pathological features and a risk factor analysis. Read More

Postgrad Med J 2019 Dec 30;95(1130):675. Epub 2019 Jul 30.

Otolaryngology, General University Hospital of Larisa, Larissa, Greece.

Am J Ophthalmol Case Rep 2019 Sep 9;15:100515. Epub 2019 Jul 9.

Department of Ophthalmology, Wake Forest University School of Medicine, Winston-Salem, NC, USA.

Purpose: To describe an unusual case of neuroretinitis complicated by macular hole (MH) development.

Observations: A full-thickness macular hole developed in a 12-year-old boy in association with serology-confirmed neuroretinitis. Following a period of observation, the MH closed without intervention. Read More

Ann Clin Microbiol Antimicrob 2019 Jul 15;18(1):23. Epub 2019 Jul 15.

Public Health and Infection Research Group, Faculty of Health Sciences, Universidad Tecnologica de Pereira, Pereira, Risaralda, Colombia.

Background: Cat-scratch disease (CSD) is a zoonotic infection caused by Bartonella henselae and B. clarridgeiae. The typical manifestations of CSD include regional lymphadenitis and fever. Read More

Curr Treat Options Neurol 2019 Jul 5;21(8):36. Epub 2019 Jul 5.

Department of Ophthalmology, Mayo Clinic, 200 First Street Southwest, Rochester, MN, 55905, USA.

Purpose Of Review: To explore and critically appraise the published data on the current and emerging treatment modalities for neuroretinitis.

Recent Findings: The optimum treatment strategy for neuroretinitis due to Bartonella henselae in immunocompetent individuals is not clear and a matter of debate. The role of systemic corticosteroids in infectious neuroretinitis and the optimum immunosuppressive regimen for use in recurrent idiopathic neuroretinitis also remains ill defined. Read More

J Fr Ophtalmol 2019 Oct 7;42(8):839-843. Epub 2019 Jun 7.

Service d'ophtalmologie, hôpital Habib Bourguiba, CHU Habib Bourguiba, 3029 Sfax, Tunisie; Université de Sfax, Tunisie.

Introduction: The diagnosis of neuroretinitis is clinical, with optic nerve involvement and a macular star. The most common etiology is cat scratch disease.

Materials And Methods: Study of 7 patients (7 eyes) with neuroretinitis. Read More

Acta Trop 2019 Sep 5;197:105056. Epub 2019 Jun 5.

College of Life Science and Engineering, Foshan University, Foshan 528231, Guangdong, China; Department of Medical Microbiology and Parasitology, Zhejiang University School of Medicine, Hangzhou 310058, Zhejiang, China. Electronic address:

Bartonella spp. are emerging vector-borne pathogens distributed worldwide that can infect humans and a wide range of mammals including small companion animals (cats and dogs). An increasing number of studies from the worldwide have reported cat and dog Bartonella infections in recently years. Read More

An Pediatr (Barc) 2019 Jun 7;90(6):393-395. Epub 2018 Jul 7.

Infectious Diseases, Nationwide Children's Hospital (NCH), Columbus, Ohio, EE.UU.. Electronic address:

Clin Rheumatol 2019 Oct 22;38(10):2691-2698. Epub 2019 May 22.

Department of Microbiology and Medical Laboratory Immunology, Medical University of Lodz, Pomorska 251, 92-231, Lodz, Poland.

Background: Bartonella spp. can cause a variety of diseases, such as lymphadenopathies, cat scratch disease, and trench fever, but can also give rise to many non-specific symptoms. No data exists regarding the prevalence of Bartonella spp. Read More

Int J Pediatr Otorhinolaryngol 2019 Jul 14;122:196-202. Epub 2019 Apr 14.

Otoneurology and Pediatric ENT Department, Hôpital Pierre Paul RIQUET, Centre Hospitalier Universitaire de Toulouse, France.

Objectives: Nontuberculous mycobacterial (NTM) lymphadenitis is a rare disease of children under 5 years. Its treatment is not standardized, even a "wait-and-see" approach is shown to be effective in the literature. Here, we discuss the diagnostic and therapeutic strategies employed in our departments. Read More

Neth J Med 2019 Apr;77(3):123

Neth J Med 2019 Apr;77(3):122

Department of Gastroenterology and Hepatology, Jeroen Bosch Ziekenhuis, 's Hertogenbosch, the Netherlands.

Trop Med Infect Dis 2019 Apr 19;4(2). Epub 2019 Apr 19.

Division of Immunology, Tulane National Primate Research Center, Tulane University Health Sciences, Covington, LA 70433, USA.

spp. bacteria can be found around the globe and are the causative agents of multiple human diseases. The most well-known infection is called cat-scratch disease, which causes mild lymphadenopathy and fever. Read More

Acta Trop 2019 Jul 14;195:142-144. Epub 2019 Apr 14.

Institute of Biomedical Sciences Abel Salazar (ICBAS), University of Porto, Oporto, Portugal; EpiUnit, Epidemiology Research Unit, Institute of Public Health of the University of Porto, Portugal; Institute of Biomedical Sciences Abel Salazar (ICBAS)Rua Jorge de Viterbo Ferreira 228, 4050-313 Porto. Electronic address:

A total of 100 domestic cats from Luanda (Angola) were tested for the presence of antibodies against Bartonella henselae and spotted fever group of Rickettsia (SFGR) using indirect immunofluorescence assay (IFA). Molecular screening targeting the riboflavin synthase (ribC) gene for Bartonella and outer membrane protein B (ompB) gene for Rickettsia, using conventional PCR and sequencing was also performed in cat´s blood samples. Sixty-six percent of the cats from Luanda had IgG antibodies against Bartonella species but none of them had antibodies against SFGR. Read More