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Neth J Med 2019 Apr;77(3):123

Neth J Med 2019 Apr;77(3):122

Department of Gastroenterology and Hepatology, Jeroen Bosch Ziekenhuis, 's Hertogenbosch, the Netherlands.

Trop Med Infect Dis 2019 Apr 19;4(2). Epub 2019 Apr 19.

Division of Immunology, Tulane National Primate Research Center, Tulane University Health Sciences, Covington, LA 70433, USA.

spp. bacteria can be found around the globe and are the causative agents of multiple human diseases. The most well-known infection is called cat-scratch disease, which causes mild lymphadenopathy and fever. Read More

Acta Trop 2019 Apr 14. Epub 2019 Apr 14.

Institute of Biomedical Sciences Abel Salazar (ICBAS), University of Porto, Oporto, Portugal; EpiUnit, Epidemiology Research Unit, Institute of Public Health of the University of Porto, Portugal; Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), Oporto, Portugal. Electronic address:

A total of 100 domestic cats from Luanda (Angola) were tested for the presence of antibodies against Bartonella henselae and spotted fever group of Rickettsia (SFGR) using indirect immunofluorescence assay (IFA). Molecular screening targeting the riboflavin synthase (ribC) gene for Bartonella and outer membrane protein B (ompB) gene for Rickettsia, using conventional PCR and sequencing was also performed in cat´s blood samples. Sixty-six percent of the cats from Luanda had IgG antibodies against Bartonella species but none of them had antibodies against SFGR. Read More

Clin Nucl Med 2019 Apr 12. Epub 2019 Apr 12.

Shanghai Universal Medical Imaging Diagnostic Center, Shanghai, China.

Cat scratch disease (CSD) is a rare zoonotic infection disease, and the imaging performance for evaluation varies. We present FDG PET/CT images of two cases of CSD. In one case, images showed typical findings of regional lymph node enlargement. Read More

BMC Infect Dis 2019 Apr 2;19(1):299. Epub 2019 Apr 2.

Department for Bacteriology and Parasitology, Croatian Veterinary Institute, Savska cesta 143, 10000, Zagreb, Croatia.

Background: The bacterial genus Bartonella is distributed worldwide and poses a public health risk. Cat-scratch disease caused by B. henselae in Croatia was first described in 1957. Read More

Eur J Case Rep Intern Med 2019 4;6(3):001038. Epub 2019 Mar 4.

Department of Internal Medicine 'B', Lady Davis Carmel Medical Center, Haifa, Israel.

species are an emerging cause of culture-negative endocarditis with more cases being diagnosed now than 25 years ago when endocarditis was first described in a patient infected with human immunodeficiency virus (HIV). Despite the disease being increasingly reported, the exact epidemiological features are not clear, with prevalence rates ranging between 2% and 10% of all cases of culture-negative endocarditis. Moreover, the mortality rate is still high, presumably because of the subacute nature and relative rareness of the disease. Read More

Genomics 2019 Mar 19. Epub 2019 Mar 19.

School of Biotechnology, Amrita Vishwa Vidyapeetham, Kollam 690 525, Kerala, India. Electronic address:

Bartonella henselae is a facultative intracellular pathogen that occurs worldwide and is responsible primarily for cat-scratch disease in young people and bacillary angiomatosis in immunocompromised patients. The principal source of genome-level diversity that contributes to B. henselae's host-adaptive features is thought to be horizontal gene transfer events. Read More

Am J Ophthalmol Case Rep 2019 Jun 23;14:58-60. Epub 2019 Feb 23.

Centro de la Visión Filial Clínica las Condes, Santiago, Chile.

Purpose: Parinaud's oculo-glandular syndrome (POGS) is the most frequent manifestation of ocular bartonellosis, and usually presents with local lymphadenopathies and systemic symptoms. We present a case of isolated conjunctival granuloma as the sole manifestation of ocular bartonellosis.

Observations: A 67-year-old female presented to the authors' eye clinic with complaints of a 2-week history of unilateral red eye and chemosis. Read More

NPJ Biofilms Microbiomes 2019 14;5:10. Epub 2019 Mar 14.

Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL USA.

() is a Gram-negative rod transmitted to humans by a scratch from the common house cat. Infection of humans with can result in a range of clinical diseases including lymphadenopathy observed in cat-scratch disease and more serious disease from persistent bacteremia. It is a common cause of blood-culture negative endocarditis as the bacterium is capable of growing as aggregates, and forming biofilms on infected native and prosthetic heart valves. Read More

Int Ophthalmol 2019 Mar 9. Epub 2019 Mar 9.

Department of Ophthalmology, Faculty of Medicine, School of Health Sciences, University of Ioannina, Stavros Niarchos Avenue, 45110, Ioannina, Greece.

Purpose: To evaluate the clinical manifestations of intraocular inflammation associated with Bartonella infection and describe the assessment and management of patients with cat-scratch disease (CSD).

Methods: This is a retrospective review of the clinical records of patients diagnosed with Bartonella henselae and Bartonella quintana intraocular inflammation from 2011 to 2018 in the Department of Ocular Inflammations and Infections of the University Eye Clinic of Ioannina (Greece). An analysis of the current literature concerning Bartonella-related intraocular infections was also carried out. Read More

Acta Trop 2019 May 27;193:163-168. Epub 2019 Feb 27.

Universidade Federal Fluminense, Faculdade de Veterinária, Departamento de Patologia e Clínica Veterinária, Rua Vital Brasil Filho, 64 - Santa Rosa, Niterói - RJ, 24230-340; Rio de Janeiro, Brazil. Electronic address:

Cats are considered main reservoir of Bartonella henselae, which is transmitted to other cats especially through Ctenocephalides felis fleas, and to humans through scratching and biting. Serra da Tiririca State Park (PESET) is an Atlantic Forest area that shelters a wide variety of endemic fauna. Recently, the park has been suffering due to irregular housing construction and domestic animal population that interacts with humans and wildlife. Read More

Child Neurol Open 2019 31;6:2329048X19826480. Epub 2019 Jan 31.

McGovern Medical School, University of Texas Health Science Center, Houston, TX, USA.

The authors describe a 12-year-old girl with an atypical presentation of encephalitis. She presented with fever and altered mental status and developed flaccid paralysis of her left upper extremity a day later. An electroencephalogram showed slowing over her right hemisphere. Read More

PLoS One 2019 8;14(2):e0211945. Epub 2019 Feb 8.

Microbiology section, Department of Public Health and Pediatrics, University of Torino, Turin, Italy.

Cat scratch disease (CSD) is an infectious disease caused by Bartonella henselae, usually characterized by self-limiting regional lymphadenopathy and fever. Given the low clinical diagnostic sensitivity and specificity of conventional anti-B. henselae indirect immunofluorescence assays (IFAs), real-time polymerase chain reaction (PCR)-based detection of B. Read More

Ann Parasitol 2018;64(4):309-315

Department of Epizootiology and Clinic of Infectious Diseases, Faculty of Veterinary Medicine, University of Life Sciences, ul. Głęboka 30, 20-612 Lublin, Poland

Bartonellosis is a disease caused by Bartonella spp. microorganisms which belong to the Rickettsiales order. This disease is a zoonosis, B. Read More

Ter Arkh 2018 Nov;90(11):105-111

Central Research Institute of Epidemiology, Federal Supervision Service for Consumer Rights Protection and People's Welfare, Moscow, Russia.

The article discusses the problem of the role of pets as a source of zoonotic infections, representing a hidden threat to modern society. Since the content is now very popular at home, both traditional and exotic animals, it is necessary to develop an interdisciplinary program to control the spread of zoonotic infections and the risks of their infection with people. Since the problem lies in the intersection of several disciplines, joint efforts of doctors, veterinarians, health organizers and laboratory specialists are necessary. Read More

Retin Cases Brief Rep 2019 Jan 23. Epub 2019 Jan 23.

Department of Ophthalmology, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan.

Purpose: To report a case of cat scratch disease-associated retinitis diagnosed with an indirect fluorescent antibody (IFA) assay for immunoglobulin M (IgM) specific for a strain (YH-01) of Bartonella henselae recently identified in Japan.

Methods: Case report of a 24-year-old pregnant woman presented with general fever, fatigue, as well as blurred vision, and a central visual field deficiency in her right eye and was suspected as cat scratch disease because she had started to feed a feral dog a month ago.

Results: The patient's serum tested negative, however, with an IFA assay for IgG or IgM specific for the Houston-1, common strain of B. Read More

Dermatol Online J 2018 Dec 15;24(12). Epub 2018 Dec 15.

Department of Dermatology, Coimbra University Hospital, Coimbra.

A 41-year-old woman presented with a violaceous papule on the dorsum of the hand, large ipsilateral axillary lymphadenopathy, and tender, erythematous, subcutaneous nodules on the legs. Accompanying signs included fever, ankle swelling, and bilateral red eye. She recalled having a previous exposure to kittens one month before and had a positive family history for sarcoidosis. Read More

Acta Biomed 2019 Jan 15;89(4):585-588. Epub 2019 Jan 15.

Department of Imaging, Bambino Gesù Children's Hospital, Rome, Italy.

Cat-scratch disease (CSD) is usually a self-limiting infection that in the majority of cases occurs as lymphadenitis in children who have been scratched or bitten by a cat. Rarely, Bartonella henselae is cause of fever of unknown origin (FUO), with dissemination to various organs, mimicking an inflammatory rather than a lymphoproliferative disease. This manuscript will present a case of thoracic manifestations of CSD in an immunocompetent 2-years baby without history of cat contact, with fever of unknown origin, investigated by chest CT and MRI. Read More

Eur J Pediatr 2019 Apr 14;178(4):463-471. Epub 2019 Jan 14.

Pediatric Otorhinolaryngology, Department of Pediatrics, Ospedale Infantile Regina Margherita, Piazza Polonia 94, 10126, Turin, Italy.

Pediatric neck masses are a common occurrence and often represent a diagnostic challenge. The primary aim of this retrospective study was to evaluate the clinical and radiological features of neck masses in children and how they can drive diagnosis. The secondary aim was to create a diagnostic algorithm based on clinical features. Read More

Vector Borne Zoonotic Dis 2019 Apr 27;19(4):234-241. Epub 2018 Dec 27.

1 Intracellular Pathogens Research Laboratory, Comparative Medicine Institute, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina.

Historically, Bartonella spp. have been associated with febrile illness (Oroya fever, trench fever, and cat scratch disease), endocarditis (numerous Bartonella spp.), and vasoproliferative lesions (Bartonella bacilliformis, Bartonella quintana, Bartonella henselae, and Bartonella vinsonii subsp. Read More

Pediatr Blood Cancer 2019 Apr 17;66(4):e27573. Epub 2018 Dec 17.

Infectious Disease Research Program, Center for Bone Marrow Transplantation, Department of Pediatric Hematology and Oncology, Children's University Hospital Münster, Münster, Germany.

Bartonella henselae, the causative agent of cat-scratch disease, has been recognized to be responsible for a broad range of clinical syndromes. We report the case of a patient with disseminated B. henselae infection mimicking Langerhans cell histiocytosis at presentation and its successful management with neurosurgery, prolonged antibacterial therapy, and observation. Read More

Int J Clin Pharm 2018 Dec 16;40(6):1458-1461. Epub 2018 Nov 16.

College of Pharmacy, The Ohio State University, 500 W. 12th Ave, Columbus, OH, 43210, USA.

Background Appropriate antibiotic treatment of cat scratch disease (CSD) in pediatrics is not well established. Objective The purpose of this study was to evaluate the response rates of antibiotic therapy in pediatrics with CSD. Methods The electronic medical records of a cohort of pediatric patients with confirmed diagnosis of CSD (2006-2016) were reviewed, retrospectively. Read More

Cas Lek Cesk Summer 2018;157(3):146-151

A retrospective evaluation of a group of patients with cat-scratch disease which is focused on epidemiological context, clinical picture, serological diagnosis and treatment in children and adults. Seventy-three patients with catch-scratch disease (CSD) were diagnosed at the Clinic of infectious medicine in 2008-2017, the group consisted of 37 children and 36 adults. Injury, or at least contact with cat, localization of lymph node syndrome and other clinical signs were investigated. Read More

Acta Reumatol Port 2018 Jul-Sep;43(3):241-242

Centro Hospitalar São João.

N Engl J Med 2018 Nov;379(18):e31

Universidad de Antioquia, Medellín, Colombia

Neurol Sci 2019 Feb 27;40(2):261-268. Epub 2018 Oct 27.

Neurology Department, Complejo Hospitalario Universitario Pontevedra, Loureiro Crespo, 2, 36002, Pontevedra, Spain.

Objective: Neurological symptoms in patients with cat-scratch disease (CSD) have been rarely reported. The aim of this study is to analyze the frequency of neurological CSD (NCSD) and describe the disease clinical presentation, management and outcome.

Material And Methods: We retrospectively selected patients with a CSD syndrome and Bartonella IgG titers > 1:256. Read More

J Ophthalmic Inflamm Infect 2018 Oct 17;8(1):18. Epub 2018 Oct 17.

Department of Ophthalmology, Faculty of Medicine, Fattouma Bourguiba University Hospital, University of Monastir, Monastir, Tunisia.

Background: Acute multifocal retinitis is a rare condition that has been considered to be often idiopathic. The purpose of this study was to analyze clinical features and causes of acute multifocal retinitis.

Results: This study is a retrospective review of the charts of 35 patients with acute multifocal retinitis. Read More

Avicenna J Med 2018 Oct-Dec;8(4):157-159

Department of Pediatrics and Human Development, College of Human Medicine, Michigan State University, East Lansing, MI, USA.

, the causative agent of cat scratch disease (CSD), is one of the most common causes of regional lymphadenitis in children. Other less common manifestations of infection including fever of unknown origin, neuroretinitis, and osteomyelitis are being increasingly recognized. We describe a 3-year-old female with a recent history of typical CSD involving lymph nodes who developed osteomyelitis of the skull, a very rarely recognized complication of this infection. Read More

Vet Dermatol 2018 Dec 14;29(6):537-e180. Epub 2018 Oct 14.

Intracellular Pathogens Research Laboratory, Comparative Medicine Institute, College of Veterinary Medicine, North Carolina State University, 1050 William Moore Drive, Raleigh, NC, 27607, USA.

Background: Bartonella henselae, a Gram-negative, zoonotic, alpha-proteobacteria has been previously implicated in association with cutaneous vasoproliferative lesions (bacillary angiomatosis), nodular panniculitis and multifocal erythema (erythema multiforme) in dogs.

Objective: Describe clinical, microbiological and histological lesions in a dog with ear margin vasculitis and B. henselae infection. Read More

Indian J Surg Oncol 2018 Sep 20;9(3):411-413. Epub 2018 Jun 20.

1Department of Medicine, University of Miami Miller School of Medicine, Miami, FL 33136 USA.

A previously healthy, 47-year-old male presented to his primary care physician with the complaint of a nontender, palpable breast mass discovered coincidentally 1 month after being scratched in the same location by his pet cat. Family history revealed his father was diagnosed with a soft tissue sarcoma of the thigh, 6 months following a traumatic injury in the same location. Cat scratch disease was considered; however, antibody testing was negative. Read More

J Clin Microbiol 2018 Dec 27;56(12). Epub 2018 Nov 27.

University Hospital, Goethe-University, Institute for Medical Microbiology and Infection Control, Frankfurt am Main, Germany

causes cat scratch disease and several other clinical entities. Infections with are frequently occurring; however, the infection is only rarely diagnosed, mainly due to a lack of knowledge in the medical community. Microscopic immunofluorescence assays (IFA) are widely used for the serodiagnosis of infections but are laborious and time-consuming, and interpretation is subjective. Read More

Case Rep Nephrol 2018 19;2018:9607582. Epub 2018 Aug 19.

Department of Internal Medicine, Oakland University William Beaumont School of Medicine, Royal Oak, MI, USA.

is a fastidious organism that causes cat scratch disease, commonly associated with fever and lymphadenopathy but, in rare instances, also results in culture-negative infectious endocarditis. We describe a patient who presented with flank pain, splenic infarct, and acute kidney injury with an active urinary sediment, initially suspicious for vasculitis, which was subsequently diagnosed as endocarditis. endocarditis may present with a crescentic glomerulonephritis (GN) and elevated PR3-ANCA antibody titers, mimicking ANCA-associated GN, with 54 cases reported in the literature. Read More

Curr Opin Ophthalmol 2018 Nov;29(6):514-519

Department of Ophthalmology, Edward Harkness Eye Institute, Columbia University, New York, New York, USA.

Purpose Of Review: Neuroretinitis is an inflammatory disorder of the eye presenting with optic disc edema and the delayed development of a macular star secondary to optic nerve swelling toward the macular structures. Neuroretinitis can be divided into idiopathic, infectious (including neuroretinitis associated with cat scratch disease) and recurrent.

Recent Findings: The clinical presentation of neuroretinitis includes impaired visual acuity, dyschromatopsia, relative afferent pupillary defects and visual field abnormalities - particularly cecocentral and central scotomas. Read More

Curr Opin Ophthalmol 2018 Nov;29(6):582-587

Emory Eye Center, Emory University School of Medicine, Atlanta, Georgia, USA.

Purpose Of Review: To review the systemic and ocular complications of Bartonella spp. infections specifically cat scratch disease, encompassing epidemiology, laboratory diagnostics, ophthalmic imagining, and treatment.

Recent Findings: Recent studies have shown that ocular manifestations occur in approximately 4. Read More

Emerg Infect Dis 2018 09;24(9):1754-1755

We describe a case of coexisting transverse myelitis and Guillain-Barré syndrome related to infection with Bartonella henselae proteobacterium and review similar serology-proven cases. B. henselae infection might be emerging as a cause of myelitis and Guillain-Barré syndrome and should be considered as an etiologic factor in patients with such clinical presentations. Read More

Paediatr Int Child Health 2018 Aug 10:1-4. Epub 2018 Aug 10.

a Paediatric Unit , Hôpital Jacques Monod , Le Havre , France.

Bone infections in cat-scratch disease (CSD) are uncommon and the diagnosis can be missed. A 3-year-old boy with multifocal pelvic osteomyelitis caused by Bartonella henselae is reported. Serological tests were negative but DNA was detected by polymerase chain reaction assay of a lymph node. Read More

Am J Case Rep 2018 Aug 2;19:906-911. Epub 2018 Aug 2.

Department of Internal Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

BACKGROUND Bartonella infection is the causative organism of cat-scratch disease (CSD), which typically presents with self-limited localized lymphadenopathy. In HIV-infected patients, Bartonella infection can cause systemic illnesses with significant morbidity and mortality manifesting as bacillary angiomatosis (BA), hepatic peliosis, splenitis, bacteremic febrile illness, and other organ involvement. To the best of our knowledge, there have been no reports of HIV-infected patients presenting with generalized lymphadenopathy caused by Bartonella infection. Read More

Front Psychiatry 2018 13;9:314. Epub 2018 Jul 13.

National Reference Laboratory for Lyme Disease, National Institute of Public Health, Prague, Czechia.

Several recent studies have demonstrated the association of cat-related injuries with major depression and with depressiveness in the general population. It was suggested that cat-scratch disease, the infection with the bacterium , can be responsible for the observed association. However, no direct evidence for the role of the infection in this association has been published until now. Read More

J Comp Pathol 2018 Jul 4;162:29-42. Epub 2018 Jul 4.

Department of Cardiology, The Animal Medical Center, New York, New York, USA.

Endomyocarditis is a commonly detected post-mortem finding in domestic cats presenting for sudden onset cardiovascular death, yet the aetiology remains unresolved. Cats are documented reservoir hosts for Bartonella henselae, the infectious cause of cat scratch disease in man. Various Bartonella spp. Read More

J Pediatr 2018 10 2;201:274-280.e12. Epub 2018 Jul 2.

Pediatrics, Nationwide Children's Hospital, Columbus, OH; The Ohio State University College of Medicine, Columbus, OH.

We identified 13 patients with cat scratch (Bartonella henselae) bone infection among those admitted to a large tertiary care children's hospital over a 12-year period. The median age was 7 years and the median time from onset of illness to diagnosis was 10 days. Multifocal osteomyelitis involving spine and pelvis was common; no patient had a lytic bone lesion. Read More

Emerg Med J 2018 Aug 20;35(8):522. Epub 2018 Jul 20.

Department of Internal Medicine and Infectiology, Cliniques Universitaires Saint-Luc, Bruxelles, Belgium.

Clinical Introduction: A 37-year-old man with history of lymph node tuberculosis presented with bilateral inguinal swelling with night sweats but no fever for 2 weeks. He had a cat but he had no history of scratches. He had an extraconjugal sexual intercourse a few weeks before. Read More

Ther Adv Ophthalmol 2018 Jan-Dec;10:2515841418774423. Epub 2018 Apr 26.

Department of Ophthalmology, Dr. Rajendra Prasad Centre for ophthalmic sciences, All India Institute of Medical Sciences (AIIMS), New Delhi, 110029, India.

Background: In this paper, our aim was to describe an imaging-based empirical approach for categorizing and initiating treatment of immunocompetent patients with posterior focal retinitis, prior to the availability of results of expensive laboratory investigations.

Materials And Methods: The hospital records of 13 patients with posterior focal retinitis were reviewed.

Results: Of the 13 patients, 9 were women and 4 were men. Read More

Open Microbiol J 2018 31;12:148-153. Epub 2018 May 31.

Infectious and Tropical Diseases Unit, Department of Medical and Surgical Sciences, "Magna Graecia" University of Catanzaro, Viale Europa, 88100, Catanzaro, Italy.

Background: Bartonella species are intracellular bacteria capable of producing several diseases in humans. The three most common and wellknown diseases are cat scratch disease (CSD), caused by B. henselae, trench fever, caused by and Carrion's Disease, caused by . Read More

BMJ Case Rep 2018 Jul 6;2018. Epub 2018 Jul 6.

Internal Medicine, University of Florida College of Medicine, Gainesville, Florida, USA.

A 28-year-old man presented to our clinic over the course of 3 weeks with symptoms that progressed from mild headaches to fever, fatigue, myalgia and an enlarged right preauricular lymph node with ipsilateral conjunctivitis and upper eyelid weakness. Our differential included Epstein Barr Virus/Cytomegalovirus mononucleosis, bacterial conjunctivitis and lymphoma. We evaluated with CBC, EBV IgM Ab, lactate dehydrogenase level and a CMV IgG Ab which were all within normal limits. Read More

Jpn J Infect Dis 2018 Nov 29;71(6):397-401. Epub 2018 Jun 29.

Department of Ophthalmology, Kocaeli University School of Medicine.

Cat scratch disease (CSD) is a syndrome characterized by lymphadenopathy, fever, and skin lesions following a cat scratch or bite. Bartonella henselae is the primary bacterial agent responsible for CSD. In this report, we describe cases with atypical presentation of serologically proven B. Read More

Arch Dis Child 2019 Jan 29;104(1):3-4. Epub 2018 Jun 29.

Pediatric Infectious Disease, Department of Paediatrics, Centre Hospitalier Chrétien (CHC), Clinique de l'Espérance, Liège, Belgium.

Ann Agric Environ Med 2018 Jun 13;25(2):345-348. Epub 2018 Apr 13.

Department of Livestock, Animal Health Division.

Introduction: The paper is a case report presenting Cat Scratch Disease (CSD) in a 1.5-year- old girl. Bartoneloses, including CSD, are a group of infectious diseases which are rarely detected, therefore there are no statistical data concerning the aetiology, and the incidence of CSD noted in Poland is low in comparison with other European countries. Read More

N Z Vet J 2018 Sep 25;66(5):257-260. Epub 2018 Jun 25.

c Koret School of Veterinary Medicine , The Hebrew University of Jerusalem , Rehovot , Israel.

AIM To identify Bartonella spp. in rats from New Zealand using molecular methods. METHODS DNA was extracted from the spleens of 143 black rats (Rattus rattus) captured in the Tongariro National Park, New Zealand. Read More

Case Rep Pediatr 2018 5;2018:2750275. Epub 2018 Apr 5.

Pediatric Infectious Diseases, Our Lady of the Lake Children's Hospital, Baton Rouge, LA, USA.

is a Gram-negative bacterium and the causative agent of cat scratch disease (CSD). Atypical presentations of that involve the musculoskeletal, hepatosplenic, cardiac, or neurologic systems are rare. In this case report, we describe a case of osteomyelitis involving bilateral iliac bones complicated by hepatic lesions in a 12-year-old immunocompetent female patient. Read More