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Emerg Microbes Infect 2022 Jun 23:1-9. Epub 2022 Jun 23.

Infection hospital area of the First Affiliated Hospital of University of science and technology of China, Hefei, China.

Bartonella are fastidious, aerobic bacteria that are transmitted by blood-sucking arthropods. spp. are responsible for cat scratch disease, Carrion's disease, bacillary angiomatosis and trench fever. Read More

ARP Rheumatol 2022 Jan-Mar;1(1):98-99

Rheumatology Department, Hospital de Egas Moniz, Centro Hospitalar de Lisboa Ocidental, Lisbon, Portugal; Chronic Diseases Research Center (CEDOC), NOVA Medical School.

Cat scratch disease (CSD) is a zoonosis caused by Bartonella henselae, which is usually transmitted to humans through scratches or bites from infected cats. It is primarily a disease of children and adolescents, although it can affect individuals of any age. In approximately 10% of cases, patients can present atypical manifestations that may involve the musculoskeletal system. Read More

Pediatr Infect Dis J 2022 May 23. Epub 2022 May 23.

From the Department of Pediatrics, Hospitalization and Emergency Unit.

The indications for use of corticosteroids for persistent fever in cat scratch disease are controversial. We report the case of a 5-year-old boy diagnosed with systemic cat scratch disease, who presented with fever for 28 days and focal hepatosplenic lesions. He did not show improvement despite antibiotic treatment for 4 weeks, however, he became afebrile 24 hours after the administration of corticosteroids. Read More

BMJ Case Rep 2022 May 18;15(5). Epub 2022 May 18.

Department of Infectious Diseases, Odense University Hospital, Odense, Denmark.

We present a case of a young kidney transplanted man. He was admitted with lymphadenopathy, fluctuating fever and night sweats 2 months after a cat bite. After admission, he developed severe pain around his right hip. Read More

BMC Nephrol 2022 May 12;23(1):181. Epub 2022 May 12.

Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN, USA.

Background: Bartonella endocarditis is often a diagnostic challenge due to its variable clinical manifestations, especially when it is first presented with involvement of organs other than skin and lymph nodes, such as the kidney.

Case Presentation: This was a 13-year-old girl presenting with fever, chest and abdominal pain, acute kidney injury, nephrotic-range proteinuria and low complement levels. Her kidney biopsy showed diffuse crescentic proliferative glomerulonephritis with a full-house pattern of immune complex deposition shown by immunofluorescence, which was initially considered consistent with systemic lupus erythematous-associated glomerulonephritis (lupus nephritis). Read More

J Infect Dev Ctries 2022 04 30;16(4):712-716. Epub 2022 Apr 30.

Pediatric Infectious Diseases Department, Gazi University Medical Faculty, Ankara, Turkey.

The hepatosplenic (HS) form of cat scratch disease (CSD) is rarely seen; however, management of the treatment is challenging for clinicians. Monotherapy or combination regimens may be preferred based on severity of cases. Along with that, there are uncertainties as to the combination and duration of antibiotics effective against the microorganisms. Read More

Acta Trop 2022 Aug 1;232:106496. Epub 2022 May 1.

Departamento de Ciências Agrárias e Ambientais, Hospital Veterinário, Universidade Estadual de Santa Cruz - UESC, Campus Soane Nazaré de Andrade, Ilhéus, BA, Brazil. Electronic address:

Bartonelloses are zoonoses widely dispersed throughout the world caused by bacteria of the genus Bartonella. Domestic cats play an important role in the epidemiology of bartonelloses, since these animals are considered natural hosts of B. henselae, B. Read More

Enferm Infecc Microbiol Clin (Engl Ed) 2022 04;40(4):179-182

Departamento de Biología Animal, Biología Vegetal y Ecología, Universidad de Jaén, Jaén, Spain. Electronic address:

Introduction: The purpose of this study was to determine the prevalence of IgG antibodies against Bartonella sp. in a randomly selected sample from the population of the patients of North Sanitary District of Jaén.

Methods: We used a commercially available immunofluorescent test (Focus-Technology IFA Bartonella quintana and B. Read More

Eur J Ophthalmol 2022 Apr 21:11206721221091376. Epub 2022 Apr 21.

Department of Ophthalmology, Bordeaux Hospital, Bordeaux, France.

Purpose: To report a case series of 3 patients with choroidal granulomas due to infection in order to raise awareness about this etiology in the differential diagnosis of choroidal granulomas.

Methods, Patients: A retrospective case series of patients with choroidal granulomas due to infection who consulted between 2018 and 2020. Data were collected from the medical records (demographics, visual acuity (VA), laboratory tests, treatment, imaging). Read More

Clin Case Rep 2022 Apr 14;10(4):e04816. Epub 2022 Apr 14.

Department of General Medicine Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Okayama Japan.

A patient complaining of swelling and tenderness in her left axilla was diagnosed with cat scratch disease despite no apparent history of cat exposure. Zoonosis can occur even in the absence of cat exposure because cat flea is also the vector of the pathogen through the flea feces. Read More

Indian J Pathol Microbiol 2022 Apr-Jun;65(2):406-409

Department of Pediatric Surgery, IPGMER, Kolkata, West Bengal, India.

The most common cause of granulomatous lymphadenitis in countries like ours is mycobactrium tuberculosis followed by atypical mycobacterial infection, fungal infections, parasitic infection, cat scratch disease, lymphogranuloma venereum (inguinal lymphadenopathy), and leprosy Here, we present three cases of lymphadenopathy due to histoplasmosis in immunocompetent children. Two of them presented with fever, lymphadenopathy, initially diagnosed as granulomatous lymphadenitis consistent with tuberculosis on FNAC and were put on antitubercular drugs. However, their condition gradually became worse. Read More

J Vet Intern Med 2022 May 6;36(3):1106-1112. Epub 2022 Apr 6.

Koret School of Veterinary Medicine, The Hebrew University of Jerusalem, Rehovot, Israel.

A 2.5-year-old castrated male cat presented with fever and marked generalized lymphadenopathy of 4-months duration, despite treatment with amoxicillin-clavulanate/marbofloxacin. Abnormalities were not detected on complete blood count, serum chemistry, and FIV/FeLV test apart from a borderline, non-regenerative anemia. Read More

mSphere 2022 04 5;7(2):e0008122. Epub 2022 Apr 5.

Department of Microbiology, Fujita Health University School of Medicine, Toyoake, Aichi, Japan.

Bartonella bacilliformis is a Gram-negative bacterial pathogen that provokes pathological angiogenesis and causes Carrion's disease, a neglected tropical disease restricted to South America. Little is known about how facilitates vasoproliferation resulting in hemangioma in the skin in verruga peruana, the chronic phase of Carrion's disease. Here, we demonstrate that extracellularly secrets a passenger domain of the autotransporter BafA exhibiting proangiogenic activity. Read More

Neurology 2022 05 29;98(21):896-900. Epub 2022 Mar 29.

From the Clinic of Neurology and Psychiatry for Children and Youth (B.N., N.I., A.P., M.K., J.M., J.S., J.J.); Center for Endocrine Surgery (B.R.), Clinical Center of Serbia; Faculty of Medicine (B.R., J.S., J.J.), University of Belgrade; and Institute of Pharmacology (J.S.), Clinical Pharmacology and Toxicology, Belgrade, Serbia.

Neuroretinitis due to infection is a rare cause of vision loss in children. Two pediatric cases of acute unilateral vision loss accompanied by edema of the optic nerve on fundoscopic examination are presented. Severe causes of vision loss were excluded. Read More

Arch Argent Pediatr 2022 Apr 4;120(2):e93-e97. Epub 2022 Feb 4.

Servicio de Oftalmología, Hospital Infantil Universitario Niño Jesús de Madrid, España.

Infectious myositis, whether viral or bacterial, is frequent in pediatric age. It causes muscle pain and weakness, associated with fever and general malaise. One cause is Bartonella henselae, responsible for cat scratch disease, which sometimes causes systemic symptoms. Read More

Med J Malaysia 2022 03;77(2):255-257

Universiti Putra Malaysia, Faculty of Medicine and Health Science, Department of Paediatrics, Serdang, Selangor, Malaysia.

Cat-scratch disease is a zoonotic infection of worldwide prevalence that is endemic in tropical or subtropical countries. Likewise, melioidosis is one of the major endemic health problems in Malaysia. Epidemiologically, mixed infections of cat-scratch disease and melioidosis are possible because similar environmental conditions are needed for the transmission of both infections. Read More

Ann Med Surg (Lond) 2022 Apr 21;76:103491. Epub 2022 Mar 21.

Professor and Head of Pediatric Ophthalmology Department, Ho^pital 20, Aou^t, 1953, Casablanca, Morocco.

Introduction: In 1916, Leber's idiopathic stellate neuroretinitis (LISN) was described by Theodore Leber as a rare disease characterized by optic disc swelling associated with a macular star. This fundus appearance can have multiple causes but the etiology of Leber's idiopathic stellate neuroretinitis remains unknown.

Case Report: A 40 year-old man consulted for a progressive decline in visual acuity and a blurred vision in his left eye. Read More

Am J Ophthalmol Case Rep 2022 Jun 14;26:101475. Epub 2022 Mar 14.

West Coast Retina Medical Group, San Francisco, CA, USA.

Purpose: To describe a patient with atypical -associated ocular inflammation that manifested with recurrent, bilateral segmental periphlebitis.

Observations: A 32-year-old White man presented with multiple paracentral scotomata in each eye. Examination revealed mild vitreous cell, segmental sheathing of the retinal veins, and inflammation of the paravenous retina in each eye. Read More

Intern Med 2022 Mar 19. Epub 2022 Mar 19.

Department of Neurology, Hokkaido Neurosurgical Memorial Hospital, Japan.

Cat scratch disease (CSD) is a zoonotic infection caused by Bartonella henselae typically resulting in self-limited regional lymphadenopathy. Encephalitis is a complication with a supposedly benign prognosis, but we encountered an exceptional case. A 19-year-old Japanese woman presented with status epilepticus. Read More

Transpl Infect Dis 2022 Mar 21:e13829. Epub 2022 Mar 21.

Section of Infectious Diseases, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, USA.

In this inaugural clinicopathological conference, the invited experts discussed the diagnostic approach to central nervous system infections in immunocompromised hosts. The case presented involved a pancreas-kidney transplant recipient with multiple brain abscesses caused by Bartonella henselae. CSF metagenomic next-generation sequencing played a significant role in the diagnosis. Read More

Microbiol Spectr 2022 Apr 9;10(2):e0259621. Epub 2022 Mar 9.

The Bernard Pridan Laboratory for Molecular Biology of Infectious diseases, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.

Cat-scratch disease (CSD), caused primarily by Bartonella henselae, is a common etiology of infectious regional lymphadenopathy. Lymphadenopathy is preceded by a primary inoculation lesion and may progress to suppuration. Laboratory diagnosis of CSD is hampered by the limitations of available confirmatory tests. Read More

BMJ Case Rep 2022 Mar 4;15(3). Epub 2022 Mar 4.

Deaprtment of Public Health, Texas Tech University Health Sciences, Lubbock, Texas, USA

A 6-year-old boy was referred to the paediatric infectious disease clinic with a 2-month history of enlarged, erythematous, painless cervical lymph nodes. He initially presented to his paediatrician with a painless lesion. At that time, he was treated empirically with clindamycin and azithromycin due to a history of cat exposure. Read More

BMC Infect Dis 2022 Mar 3;22(1):213. Epub 2022 Mar 3.

2nd Department of Internal Medicine, General Hospital of Nikaia-Piraeus "Agios Panteleimon", 3 Andrea Petrou Mantouvalou Street, 185 43, Athens, Greece.

Background: Mycobacterial infections can cause significant morbidity when cellular immunity is compromised. Patients with AIDS can be affected directly from infection or through mycobacterial IRIS, especially if they are previously untreated for HIV. Herein a case of tuberculous lymphadenitis is reported, which primarily responded to antimicrobials but complicated by IRIS and cat-scratch disease at a later course. Read More

Pathogens 2022 Jan 27;11(2). Epub 2022 Jan 27.

Infectious Disease Unit, Tel Aviv Sourasky Medical Center, Tel Aviv University, Tel Aviv 6423906, Israel.

Cat scratch disease (CSD), caused by , usually presents as regional lymphadenopathy/lymphadenitis, known as typical CSD or as atypical CSD, which includes, among others, neurological manifestations. Serology for anti- IgG antibodies is the most commonly used diagnostic tests for CSD. Intravenous immunoglobulin (IVIG) is given for an increasing number of medical conditions and may cause interference with serological testing. Read More

Brain Sci 2022 Feb 4;12(2). Epub 2022 Feb 4.

County Emergency Clinical Hospital "Sf. Apostol Andrei", Tomis Street, nr. 145, 900591 Constanta, Romania.

Cat-scratch disease is an illness caused by that occurs as a result of contact with an infected kitten or dog, such as a bite or scratch. It is more prevalent in children and young adults, as well as immunocompromised individuals. There are limited publications examining the features of CSD in patients. Read More

Front Microbiol 2022 7;13:838267. Epub 2022 Feb 7.

Institute for Medical Microbiology and Infection Control, University Hospital, Goethe University, Frankfurt am Main, Germany.

is the causative agent of cat scratch disease and other clinical entities such as endocarditis and bacillary angiomatosis. The life cycle of this pathogen, with alternating host conditions, drives evolutionary and host-specific adaptations. Human, feline, and laboratory adapted isolates often display genomic and phenotypic differences that are related to the expression of outer membrane proteins, for example the adhesin A (BadA). Read More

Rev Inst Med Trop Sao Paulo 2022 21;64:e17. Epub 2022 Feb 21.

Universidade Estadual de Campinas, Faculdade de Ciências Médicas, Laboratório de Pesquisa Aplicada em Dermatologia e Infecção por Bartonella, Campinas, São Paulo, Brazil.

As leprosy and leprosy reactions are the most prevalent infectious cause of physical disability, it is important to commit efforts to better understand these chronic reactions. Infections, even when asymptomatic, can trigger leprosy reactions and Bartonella spp. in turn, can cause chronic infections. Read More

Rev Inst Med Trop Sao Paulo 2022 16;64:e15. Epub 2022 Feb 16.

Universidade Estadual de Campinas, Faculdade de Ciências Médicas, Laboratório de Pesquisa Aplicada em Dermatologia e Infecção por Bartonella, Campinas, São Paulo, Brazil.

We report the case of a 6-year-old boy that presented with enlarged lymph nodes on his neck. He complained of tiredness and discouragement, which worsened during feverish periods. There were no relevant laboratory test abnormalities and serological tests were not reactive. Read More

Rev Med Interne 2022 May 12;43(5):316-319. Epub 2022 Feb 12.

Service de médecine polyvalente, CH de Périgueux, 80, avenue Georges-Pompidou, 24019 Périgueux cedex, France.

Introduction: Cat-scratch disease is a zoonosis caused by Bartonella henselae and transmitted mostly through a break in the skin. This infectious disease is commonly characterized by a benign lymphadenitis. However, more unusual presentations have been observed. Read More

Front Cell Infect Microbiol 2022 28;12:828082. Epub 2022 Jan 28.

Intracellular Pathogens Research Laboratory, Department of Clinical Sciences, The Comparative Medicine Institute, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, United States.

Among the -borne pathogens, , the main aetiological agent of cat scratch disease (CSD), is of increasing comparative biomedical importance. Despite the importance of as an emergent pathogen, prevention of the diseases caused by this agent in cats, dogs and humans mostly relies on the use of ectoparasiticides. A vaccine targeting both flea fitness and pathogen competence is an attractive choice requiring the identification of flea proteins/metabolites with a dual effect. Read More