Zoonoses Public Health 2017 Jul 14. Epub 2017 Jul 14.

Division of Vector-Borne Diseases, Centers for Disease Control and Prevention, Fort Collins, CO, USA.

Cat scratch disease (CSD) is a zoonotic infection caused primarily by the bacterium Bartonella henselae. An estimated 12,000 outpatients and 500 inpatients are diagnosed with CSD annually, yet little is known regarding clinician experience with and treatment of CSD in the United States. Questions assessing clinical burden, treatment and prevention of CSD were posed to 3,011 primary care providers (family practitioners, internists, paediatricians and nurse practitioners) during 2014-2015 as part of the annual nationwide DocStyles survey. Read More

Epidemiol Mikrobiol Imunol 2017 ;66(2):99-104

Cat scratch disease is a relatively rare infection that is caused by the bacterium Bartonella henselae. This disease occurs after cat scratch or bite. The course of the disease depends on the patients immunity status. Read More

Eur J Clin Microbiol Infect Dis 2017 Jul 2. Epub 2017 Jul 2.

URMITE, Aix Marseille Université, UM63, CNRS 7278, IRD 198, INSERM 1095, IHU - Méditerranée Infection, 19-21 Boulevard Jean Moulin, 13385, Marseille Cedex 05, France.

Bartonella henselae, the agent of cat scratch disease (CSD), appears to be a common organism responsible for lymphadenitis in both adults and children. There is a very low isolation rate for B. henselae from lymph nodes of patients with CSD. Read More

Ocul Immunol Inflamm 2017 Jun 30:1-8. Epub 2017 Jun 30.

b Uveitis Clinic of the Ophthalmology and Visual Sciences Department , Universidade Federal de Sao Paulo Escola Paulista de Medicina , Sao Paulo , Brazil.

Purpose: Describe a case series of ocular Cat-scratch-disease (CSD) with vision-threatening findings and poor outcomes, indicating severity of disease.

Methods: Retrospective case series from the Uveitis Department of São Paulo Federal University from 2011 to 2015.

Results: In this period, six eyes of four patients had confirmed diagnosis of CSD. Read More

Rev Chilena Infectol 2017 Apr;34(2):181-185

Universidad de los Andes, Chile.

Tetanus is declining due to vaccination, professional labor management and appropriate wound care. Tetanus cases have been reported despite immunization. We report the case of a previously healthy 21 years old female patient that presented a mild generalized tetanus requiring admission after mild and recurrent cat scratch and bites. Read More

Korean J Intern Med 2017 May 20;32(3):530-535. Epub 2017 Apr 20.

Department of Internal Medicine, Inha University School of Medicine, Incheon, Korea.

Background/aims: Cat-scratch disease (CSD), caused by Bartonella henselae is one of the most common zoonosis. However, only several cases of B. henselae infection have been reported in Korea. Read More

Med Clin (Barc) 2017 Apr 14. Epub 2017 Apr 14.

Medicina Interna, Hospital Juan Ramón Jiménez, Huelva, España.

Pediatr Infect Dis J 2017 May;36(5):516-520

From the *Division of Infectious Diseases and Immunology, Department of Pediatrics, †Division of Hematology and Oncology, Department of Pediatrics, and ‡Division of Cardiology, Department of Pediatrics, Nationwide Children's Hospital, The Ohio State University, Columbus, Ohio.

Two children with congenital heart disease status post surgical correction presented with prolonged constitutional symptoms, hepatosplenomegaly and pancytopenia. Concern for malignancy prompted bone marrow biopsies that were without evidence thereof. In case 1, echocardiography identified a multilobulated vegetation on the conduit valve. Read More

Genome Announc 2017 Mar 30;5(13). Epub 2017 Mar 30.

Food Safety Laboratory, Platform IdentyPath, Université Paris-Est, Anses, Maisons-Alfort, France

Bartonella henselae is the main causative agent of cat scratch disease. In this report, we present the draft genome sequences of 12 strains of Bartonella henselae originating from the United States, Denmark, and France. These strains were isolated from cats and belonged to either 16S rRNA genotype I or 16S rRNA genotype II. Read More

Emerg Infect Dis 2017 Apr;23(4):712-713

Each year in the United States, 500 patients are hospitalized for cat-scratch disease, caused by Bartonella henselae infection. We report a case of rare but serious neurologic B. henselae infection. Read More

Reumatol Clin 2017 Feb 27. Epub 2017 Feb 27.

Centro de Patología y Citología (CEPACIT), Ciudad Autónoma de Buenos Aires, Argentina.

Cat scratch disease (CSD) is an infectious disorder caused by Bartonella henselae and characterized by fever and granulomatous lymphadenopathy. Immunosuppression is a risk factor for the development of atypical forms of the disease. We report the case of a 52-year-old woman who presented with fever and bilateral inguinal lymph node enlargement. Read More

Acta Gastroenterol Belg 2016 Sep-Dec;79(4):497-499

Cat-scratch disease (CSD) is an emerging zoonosis caused by Bartonella henselae. The disease is usually self-limiting and typically presents in about 90% of all cases as a subacute regional lymphadenopathy. We present a case report of an unusual CSD presentation, persistent hepatic granulomatous disease due to Bartonella henselae infection despite combination therapy with doxycycline and rifampicin. Read More

Transpl Infect Dis 2017 Jun 26;19(3). Epub 2017 May 26.

Division of Cardiology, Department of Medicine, Medical University of South Carolina, Charleston, SC, USA.

We report the case of an afebrile 59-year-old heart transplant recipient presenting with nausea, vomiting, diarrhea, weight loss, and diffuse lymphadenopathy. Lymph node biopsies revealed non-caseating granulomatous inflammation. Cat-scratch disease was confirmed by serologic studies, Warthin-Starry staining, and polymerase chain reaction testing of lymph node tissue. Read More

Turk J Ophthalmol 2017 Jan 17;47(1):9-17. Epub 2017 Jan 17.

İstanbul University İstanbul Faculty of Medicine, Department of Ophthalmology, İstanbul, Turkey.

Objectives: To describe ocular manifestations, diagnosis, and treatment of cat scratch disease.

Materials And Methods: Clinical records of patients with ocular cat scratch disease were reviewed.

Results: Thirteen eyes of 10 patients (7 female, 3 male) with a mean age of 26. Read More

Microb Ecol 2017 Aug 2;74(2):474-484. Epub 2017 Feb 2.

Microbial Pathogenesis and Host Defense Program, University of California, San Francisco, San Francisco, CA, 94143-0654, USA.

Bartonella henselae is an emerging bacterial pathogen causing cat-scratch disease and potentially fatal bacillary angiomatosis in humans. Bacteremic cats constitute a large reservoir for human infection. Although feline vaccination is a potential strategy to prevent human infection, selection of appropriate B. Read More

Vet Rec 2017 Apr 27;180(13):325. Epub 2017 Jan 27.

Clinic of Small Animal Medicine, Centre for Clinical Veterinary Medicine, LMU Munich, Veterinaerstrasse 13, Munich 80539, Germany.

Bartonella species are zoonotic pathogens, and infections in cats are common. However, prevalence in cats in Southern Germany is still unknown. Therefore, prevalence of Bartonella species DNA in blood of 479 Southern German cats was determined using a previously published conventional PCR targeting a fragment of the 16S-23S rRNA intergenic spacer region. Read More

Diagn Microbiol Infect Dis 2017 Jan 11;87(1):22-24. Epub 2016 Oct 11.

Department of Clinical Laboratory Science, Graduate School of Medicine, Yamaguchi University, Ube, Yamaguchi 755-8505, Japan.

Bartonella henselae strains genetically differ among nations. The utility of Japanese-specific YH-01 strain was investigated in developing indirect fluorescence antibody assay (IFA) for IgM in comparison with conventional IFA employing Houston-1 strain by testing 100 Japanese patients suspected of cat scratch disease. The country-specific IFA greatly improved the accuracy of diagnosis. Read More

Clin Pediatr (Phila) 2016 Dec 1:9922816684606. Epub 2016 Dec 1.

1 Baylor College of Medicine, San Antonio, TX, USA.

Hepatosplenic cat-scratch disease (CSD) may cause prolonged fever. We present the case of a 4-year-old boy with confirmed hepatosplenic CSD with fever lasting 3 months despite use of multiple different antimicrobial agents. The patient became afebrile soon after corticosteroid therapy was started. Read More

Clin Nucl Med 2017 Feb;42(2):106-107

From the *Nuclear Medicine Department, †Hematology Department, and ‡Histopathology Department, Hospices Civils de Lyon, Université de Lyon 1, France.

FDG-PET/CT is a standard of care in staging and response assessment of Hodgkin lymphoma. Hence, it is important to recognize pitfalls owing to the potential therapeutic impact. We report a case of a 29-year-old woman affected by stage III bulky Hodgkin lymphoma. Read More

Parasitology 2017 May 12;144(6):773-782. Epub 2016 Dec 12.

Departamento de Patologia Veterinária, Faculdade de Ciências Agrárias e Veterinárias,Universidade Estadual Paulista (FCAV/UNESP),Jaboticabal, SP,Brazil.

The present study determined the prevalence, hematological findings and genetic diversity of Bartonella spp. in domestic cats from Valdivia, Southern Chile. A complete blood count and nuoG gene real-time quantitative PCR (qPCR) for Bartonella spp. Read More

Am Fam Physician 2016 Nov;94(10):794-802

School of Veterinary Sciences, University of Bristol, Langford, United Kingdom.

Physicians and veterinarians have many opportunities to partner in promoting the well-being of people and their pets, especially by addressing zoonotic diseases that may be transmitted between a pet and a human family member. Common cutaneous pet-acquired zoonoses are dermatophytosis (ringworm) and sarcoptic mange (scabies), which are both readily treated. Toxoplasmosis can be acquired from exposure to cat feces, but appropriate hygienic measures can minimize the risk to pregnant women. Read More

Neuroophthalmology 2015 Dec 14;39(6):266-270. Epub 2015 Dec 14.

Department of Ophthalmology, Fattouma Bourguiba University Hospital, Faculty of Medicine, University of Monastir , Monastir, Tunisia.

The purpose of this study was to determine final diagnosis of patients referred with a diagnosis of neuroretinitis. A retrospective study of 40 patients with optic disc oedema with macular star (ODOMS) referred with a diagnosis of neuroretinitis was conducted. The final diagnosis was neuroretinitis in 26 patients (65%), with most of these patients (96. Read More

Acta Crystallogr F Struct Biol Commun 2016 Dec 25;72(Pt 12):885-891. Epub 2016 Nov 25.

Thomas H. Gosnell School of Life Sciences, Rochester Institute of Technology, 85 Lomb Memorial Drive, Rochester, NY 14623-5603, USA.

In bacteria, the second committed step in the diaminopimelate/lysine anabolic pathways is catalyzed by the enzyme dihydrodipicolinate reductase (DapB). DapB catalyzes the reduction of dihydrodipicolinate to yield tetrahydrodipicolinate. Here, the cloning, expression, purification, crystallization and X-ray diffraction analysis of DapB from the human-pathogenic bacterium Bartonella henselae, the causative bacterium of cat-scratch disease, are reported. Read More

Front Microbiol 2016 7;7:1750. Epub 2016 Nov 7.

Department of Molecular Medicine and Medical Biotechnology, Federico II University Medical SchoolNaples, Italy; CEINGE-Advanced BiotechnologiesNaples, Italy.

Bartonella henselae is a gram-negative facultative intracellular bacterium and is the causative agent of cat-scratch disease. Our previous data have established that Bacteroides fragilis colonization is able to prevent B. henselae damages through the polysaccharide A (PSA) in an experimental murine model. Read More

Ocul Oncol Pathol 2016 Oct 1;2(4):246-250. Epub 2016 Jul 1.

Department of Ophthalmology, Cole Eye Institute, Ohio, USA.

Background: To expand the spectrum of ophthalmic manifestations in cat scratch disease.

Methods: Case report.

Results: A 7-year-old male was referred for evaluation of his left optic disc after failing vision screening test at school. Read More

Pediatr Emerg Care 2016 Nov;32(11):789-791

From the *Department of Emergency Medicine, University of North Carolina School of Medicine, Chapel Hill; †Departments of Emergency Medicine and Pediatric Emergency Medicine; ‡Department of Pediatrics, Pediatric Critical Care, WakeMed Health and Hospitals, Raleigh, NC; and §Department of Pediatrics, University of North Carolina School of Medicine, Chapel Hill, NC.

Despite the publication of a number of case reports since the 1950s, physician awareness of the unique relationship between cat scratch disease (CSD) and acute encephalopathy remains limited. This report alerts emergency medicine physicians to include CSD encephalopathy (CSDE) in the differential diagnosis when a previously healthy child presents with status epilepticus. Prompt recognition of this relationship impacts the selection of initial diagnostic studies and antibiotic choices and permits reliable insight into prognosis. Read More

Intern Med 2016;55(20):3065-3067. Epub 2016 Oct 15.

Department of General Medicine, Chiba University Hospital, Japan.

A 65-year-old Japanese man was admitted with a 4-month history of fatigue and exertional dyspnea. Transthoracic echocardiography revealed a vegetation on the aortic valve and severe aortic regurgitation. Accordingly, infective endocarditis and heart failure were diagnosed. Read More

J Neurosurg Pediatr 2016 Dec 23;25(6):713-716. Epub 2016 Sep 23.

Departments of 1 Neurological Surgery and.

Osteomyelitis of the spine with associated spinal epidural abscess represents an uncommon entity in the pediatric population, requiring prompt evaluation and diagnosis to prevent neurological compromise. Cat scratch disease, caused by the pathogen Bartonella henselae, encompasses a wide spectrum of clinical presentations; however, an association with osteomyelitis and epidural abscess has been reported in only 4 other instances in the literature. The authors report a rare case of multifocal thoracic osteomyelitis with an epidural abscess in a patient with a biopsy-proven pathogen of cat scratch disease. Read More

Emerg Infect Dis 2016 Oct;22(10):1741-6

Cat-scratch disease (CSD) is mostly preventable. More information about the epidemiology and extent of CSD would help direct prevention efforts to those at highest risk. To gain such information, we reviewed the 2005-2013 MarketScan national health insurance claims databases and identified patients <65 years of age with an inpatient admission or outpatient visit that included a CSD code from the International Classification of Diseases, Ninth Revision, Clinical Modification. Read More

Rev Chilena Infectol 2016 Jun;33(3):355-7

Laboratorio de Virología e Infectología Molecular, Pontificia Universidad Católica de Chile, Santiago, Chile.

Introduction: Bartonella henselae infection is a worldwide zoonosis with the domestic cat as reservoir. Although people with occupational contact with these pets are risk population only few studies of prevalence in them have been reported.

Methods: A study of seroprevalence of B. Read More

Clin Ter 2016 Jul-Aug;167(4):101-4

Meyer Children's Hospital, Department of Radiology, Florence.

Cat-scratch disease (CSD) is a zoonosis in children, result of infection by Bartonella henselae, a gram-negative bacillus. Infection is generally characterized by regional and self-limited lymphadenopathy after exposure to a scratch or bite from a cat. Rarely, B. Read More

Clin Gastroenterol Hepatol 2017 Jan 30;15(1):e5-e6. Epub 2016 Jul 30.

Division of Infectious Disease and International Medicine, Department of Internal Medicine, University of South Florida, Tampa, Florida.

J Ultrason 2016 Jun 29;16(65):204-9. Epub 2016 Jun 29.

Department of Transplantation, Children's University Hospital, Krakow, Poland.

Infections in immunocompromised patients after hematopoietic stem cell transplantation can have a severe and atypical course. Some opportunistic pathogens are difficult to detect in microbiological tests, and that is why treatment success depends on an accurate clinical diagnosis. This article presents a case of a 7-year-old girl with severe aplastic anemia treated with bone marrow transplantation with post-transplantation period complicated by persistent, hectic fever, with peak episodes of 39-40°C, lasting several weeks. Read More

Enferm Infecc Microbiol Clin 2017 Jan 15;35(1):58-59. Epub 2016 Jul 15.

Departamento de Enfermedades Infecciosas, Hospital San Pedro-CIBIR, Logroño, La Rioja, Spain.

J Pak Med Assoc 2016 Jun;66(6):654-7

Department of Paediatrics, Haseki Training and Research Hospital, Istanbul, Turkey.

Objective: To determine the causes of lymphadenopathies in children living in our region, and detect the frequency of malignant disease.

Methods: Our study evaluated demographic characteristics, lymph node involvement sites, tests, and viral serologiesperformed to search for the presence of infection, and ultrasonographic, and histologic findings of 1700 children who were referred to the outpatient clinics of the Paediatric Diseases and Paediatric Surgery between January 2012, and January 2015.

Results: Our study population consisted of 1003 (59 %) boys, and 697 (41 %) girls aged less than 18 years. Read More

Prog Transplant 2016 Sep 16;26(3):227-30. Epub 2016 Jun 16.

Division of Nephrology, Department of Internal Medicine, Istanbul University Cerrahpasa Medical Faculty, Istanbul, Turkey.

Cat scratch disease (CSD) is a disorder characterized by self-limited regional lymphadenopathy and fever. We reported a case of CSD in a kidney transplant recipient who presented with fever and lymphadenopathy. Lymph node biopsy demonstrated bacterial histiocytic lymphadenitis. Read More

Asian Pac J Trop Med 2016 Jun 23;9(6):610-3. Epub 2016 Mar 23.

Clínica Pediatrica, Hospital Edgardo Rebagliati Martins, Jirón Edgardo Rebagliati NO. 490 Jesús María, Lima, Peru.

Cat scratch's disease caused by Bartonella henselae, is known to be a self-limited benign process in immunocompetent children. The association with neurologic manifestations is very uncommon especially in patient with no immunologic defects and in cases without specific treatment. A 7 years old male patient, without any immunocompromised defect, presented an atypic presentation of the cat scratch disease. Read More

Radiol Case Rep 2016 Jun 8;11(2):54-7. Epub 2016 Apr 8.

Department of Radiology, University of Kansas Medical Center, 3901 Rainbow Boulevard, Mail Stop 4032, Kansas City, KS 66160, USA.

A 51-year-old man with history of undiagnosed pulmonary nodules 4 years prior, presented with right-sided chest pain. Acute cardiac workup was negative, and a chest computed tomography examination demonstrated marked improvement in bilateral pulmonary nodules. A concordant abdominal computed tomography examination showed new subcentimeter hypodense lesions throughout the liver and spleen, mild progressive abdominopelvic lymphadenopathy, and new small lytic lesions of T11 and L4 vertebrae. Read More

Aten Primaria 2017 Mar 24;49(3):196-197. Epub 2016 May 24.

Servicio de Otorrinolaringología, Hospital de Jarrio, Coaña, Asturias, España.

Vet Res Forum 2016 15;7(1):69-72. Epub 2016 Mar 15.

Department of Internal Medicine, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran;

One of the most important species of the Bartonella genus is B. henselae that causes a zoonotic infection, cat scratch disease (CSD). The main source of the bacteria is cat and the carrier is Ctenocephalides felis flea. Read More

Pol Przegl Chir 2016 Mar;88(2):109-12

Cat scratch disease (CSD) - bartonellosis, is zoonosis caused by the intracellular gram negativebacterium Bartonellahenselae or Bartonellaquintana. The pathogens of this disease enter the human body usually as a consequence of a bite or scratch by young cats which are the natural source of such bacteria. The illness proceeds asymptomatically or with topical symptoms of infection such as a lump, spot or blister. Read More

Skeletal Radiol 2016 Sep 18;45(9):1227-34. Epub 2016 May 18.

Uniformed Services University of the Health Sciences, Bethesda, MD, USA.

Objective: Evaluate anatomic and imaging features of epitrochlear regional adenopathy secondary to cat scratch disease (CSD) to assist differentiation of CSD from other soft tissue masses at the elbow.

Materials And Methods: Retrospective review of 24 confirmed cases of CSD. Patient demographics, clinical presentation and radiographic (R; n = 10), CT (n = 3), ultrasound (US; n = 5), and MR (n = 21) images were reviewed. Read More

Rev Esp Salud Publica 2016 May 5;90:E5. Epub 2016 May 5.

Departamento de Patología Animal. Facultad de Veterinaria de Zaragoza. Zaragoza. España.

Objective: Bartonella henselae is responsible for the Cat Scratch Disease in humans, being it underdiagnosed. This study aims to detect and quantify the load of B. henselae DNA in oral and whole blood samples from stray and shelthered cats from Zaragoza (Spain), and analyze associations with epidemiological and clinical factors. Read More

Paediatr Int Child Health 2016 Jan 12:1-3. Epub 2016 Jan 12.

b Department of Pediatrics , Chang Gung Memorial Hospital , Linkou , Taiwan.

Cat scratch disease (CSD) can present as a systemic disease in 5-10% of cases and lead to various disease entities. A previously healthy 16-month-old boy presented with fever for 7 days without other obvious symptoms. Abdominal computed tomography scan demonstrated enlarged right inguinal lymph nodes and multiple small round hypodensities in the spleen. Read More

IDCases 2016 19;4:13-4. Epub 2016 Feb 19.

Department of Pediatrics, Asahi General Hospital, Chiba, Japan.

Minerva Pediatr 2016 Mar 23. Epub 2016 Mar 23.

Department of Pediatrics, "Sapienza" University of Rome, Rome, Italy -

Background: Symptomatic Bartonella henselae infection is considered rare in Europe. Cat fleas transmit the microorganism between cats, but their role in transmission of B. henselae to humans has not been defined. Read More

PLoS Negl Trop Dis 2016 Mar 21;10(3):e0004509. Epub 2016 Mar 21.

Department of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America.

Bacteria from the genus Bartonella are emerging blood-borne bacteria, capable of causing long-lasting infection in marine and terrestrial mammals, including humans. Bartonella are generally well adapted to their main host, causing persistent infection without clinical manifestation. However, these organisms may cause severe disease in natural or accidental hosts. Read More

Arch Soc Esp Oftalmol 2017 Jan 17;92(1):37-39. Epub 2016 Mar 17.

Servicio de Oftalmología, Hospital Universitario Central de Asturias, Oviedo, Principado de Asturias, España.

Clinical Case: A 33-year old woman presents with unilateral granulomatous conjunctivitis, ipsilateral regional lymphadenopathy and fever. A Bartonella henselae infection is demonstrated by indirect immunofluorescence, and a diagnosis of a Parinaud's oculoglandular syndrome is established. Outcome after treatment with oral doxycycline is satisfactory. Read More

J Fr Ophtalmol 2016 Mar 3;39(3):e59-61. Epub 2016 Mar 3.

Service d'ophtalmologie, CHU Dupuytren, 2, avenue Martin-Luther-King, 87000 Limoges, France.

Emerg Infect Dis 2016 Mar;22(3):544-6

Lymphadenopathy and fever that developed in a woman in Tbilisi, Georgia, most likely were caused by a ratborne Bartonella strain related B. tribocorum and B. elizabethae. Read More