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J Bone Jt Infect 2021 20;6(6):171-178. Epub 2021 May 20.

Infectious Diseases Department, Dijon University Hospital, Dijon, France.

is the bacterial agent responsible for cat scratch disease. This infection is frequently the cause of localized lymphadenitis in children. It is also sometimes responsible for endocarditis, encephalitis, hepatic peliosis and in rare cases osteomyelitis. Read More

Cureus 2021 May 24;13(5):e15206. Epub 2021 May 24.

Pathology, Giresun University Faculty of Medicine, Giresun, TUR.

Since idiopathic granulomatous lobular mastitis, also known as idiopathic granulomatous mastitis or granulomatous lobulitis, was first described by Kessler and Wolloch in 1972, no consensus on the ideal and definitive treatment for this phenomenon has been reached thus far. Idiopathic granulomatous lobular mastitis mostly frequently observed in women of childbearing age within a few years of pregnancy with a higher incidence in patients of Hispanic, Native American, Middle Eastern, and African descent. This entity, , is a rare, benign, chronic inflammatory breast condition of unknown aetiology mimicking two common breast disorders. Read More

Cureus 2021 Apr 22;13(4):e14632. Epub 2021 Apr 22.

Rheumatologist Policlinic Department, Communal Non-Commercial Enterprise of Kharkov Regional Council "Regional Clinical Hospital", Kharkiv, UKR.

Cat scratch disease (CSD) is often a rare and unrecognized illness, but it is important for practitioners to consider. CSD is commonly diagnosed in children, but adults may also get this disease. The manifestations of CSD can include the damage of internal organs, joints, eyes, heart, and kidneys. Read More

Pediatr Infect Dis J 2021 May;40(5S):S11-S15

From the Division of Pediatric Infectious Diseases, Harbor-UCLA Medical Center, Los Angeles, California.

Since the early 1900s, Bartonella species were known only to cause human disease resulting from very restricted geographic (bartonellosis) or environmental influences ("trench fever"). In the 1990s, and in parallel, cat scratch disease and bacillary angiomatosis were definitively linked to Bartonella species. Subsequently, widespread use of modern diagnostic methods revealed the broad ecologic niche of this organism and greatly expanded our knowledge of the epidemiology and clinical presentations associated with this genus. Read More

Infect Immun 2021 May 24. Epub 2021 May 24.

Laboratory Affiliated to Istituto Pasteur Italia-Fondazione Cenci Bolognetti, Department of Molecular Medicine, Sapienza University of Rome, Italy.

Some bacterial pathogens can manipulate the angiogenic response, suppressing or inducing it for their own ends. In humans, is associated with cat-scratch disease and vasculoproliferative disorders such as bacillary angiomatosis and bacillary peliosis. Although endothelial cells (ECs) support the pathogenesis of , the mechanisms by which induces EC activation are not completely clear, as well as the possible contribution of other cells recruited at the site of infection. Read More

Pediatr Int 2021 May 17. Epub 2021 May 17.

Department of, Pediatric Infectious Diseases, Istanbul Medical Faculty, Istanbul University, Istanbul, Turkey.

Nephrol Ther 2021 May 10. Epub 2021 May 10.

Centre de référence des Maladies rénales rares, service de néphrologie, rhumatologie et dermatologie pédiatriques, Hôpital Femme-Mère-Enfant, Hospices civils de Lyon, 59, boulevard Pinel, 69677 Bron cedex, France. Electronic address:

Cat scratch disease, usually a benign infectious disease, may develop as multisystem disease with multiorgan involvement, particularly in immunocompromised patients. We report on a patient who developed disseminated bartonellosis while receiving mycophenolate mofetil monotherapy treating steroid-dependent nephrotic syndrome, highlighting that severe infection can be observed in those patients. Therefore, this category of patients should be cautious when having contact with kittens and receives proper prevention advice. Read More

Pediatr Infect Dis J 2021 Jan;40(1):48

Microorganisms 2021 Apr 28;9(5). Epub 2021 Apr 28.

Pediatric Clinic, Pietro Barilla Children's Hospital, University of Parma, Via Gramsci 14, 43126 Parma, Italy.

In most cases, infection due to causes a mild disease presenting with a regional lymphadenopathy frequently associated with a low-grade fever, headache, poor appetite and exhaustion that spontaneously resolves itself in a few weeks. As the infection is generally transmitted by cats through scratching or biting, the disease is named cat scratch disease (CSD). However, in 5-20% of cases, mainly in immunocompromised patients, systemic involvement can occur and CSD may result in major illness. Read More

Pathogens 2021 Apr 22;10(5). Epub 2021 Apr 22.

Center for Agricultural Biotechnology, Kamphaeng Saen Campus, Kasetsart University, Nakhon Pathom 73140, Thailand.

(1) Background: spp. are Gram-negative, facultative, intracellular bacteria transmitted by hematophagous insects. Several species cause zoonotic diseases such as cat-scratch disease. Read More

Microorganisms 2021 Apr 14;9(4). Epub 2021 Apr 14.

Department of Molecular Medicine, MDC7, Morsani College of Medicine, University of South Florida, 12901 Bruce B. Downs Blvd., Tampa, FL 33612, USA.

() is a gram-negative bacterium that causes cat scratch disease, bacteremia, and endocarditis, as well as other clinical presentations. has been shown to form a biofilm in vitro that likely plays a role in the establishment and persistence of the bacterium in the host. Biofilms are also known to form in the cat flea vector; hence, the ability of this bacterium to form a biofilm has broad biological significance. Read More

J Neuroophthalmol 2021 Apr 14. Epub 2021 Apr 14.

Department of Ophthalmology (SL-N, TP, HL, OY), Kaplan Medical Center, Rehovot, Israel; Hadassah Medical School and the Hebrew University (HL, OY, DR, RG), Jerusalem, Israel; Department of Ophthalmology (DR), Shaare Zedek Medical Center, Jerusalem, Israel; and Department of Neurology (VS, RG), Kaplan Medical Center, Rehovot, Israel.

N Engl J Med 2021 Apr;384(15):1448-1456

From the Departments of Medicine (R.C.C., A.M.N.), Radiology (M.S.), Pediatrics (A.M.N.), and Pathology (A.R.S.), Massachusetts General Hospital, and the Departments of Medicine (R.C.C., A.M.N.), Radiology (M.S.), Pediatrics (A.M.N.), and Pathology (A.R.S.), Harvard Medical School - both in Boston.

Eur J Clin Microbiol Infect Dis 2021 Apr 12. Epub 2021 Apr 12.

Centre National de Référence des Rickettsies, Coxiella et Bartonella IHU-Méditerranée Infection, APHM, Marseille, France.

We studied retrospectively 651 PCR-confirmed Bartonella infections diagnosed at the French reference center for bartonellosis from 2014 to 2019. The most common form was cat-scratch disease (89%) followed by endocarditis (9%). Disseminated forms (2%) mainly presented as bacillary angiomatosis or peliosis hepatis in solid organ transplant recipients. Read More

Pathogens 2021 Mar 17;10(3). Epub 2021 Mar 17.

KB One Health LLC, Fort Collins, CO 80521, USA.

Cat-associated species, which include , , and can cause mild to severe illness in humans. In the present study, we evaluated 1362 serum samples obtained from domestic cats across the U.S. Read More

Pathogens 2021 Mar 11;10(3). Epub 2021 Mar 11.

Departament de Medicina i Cirurgia Animals, Facultat de Veterinària, Universitat Autònoma de Barcelona, Bellaterra, 08193 Barcelona, Spain.

Cats are the primary reservoir host for ), an etiological agent of human bartonellosis, including cat scratch disease. Although DNA has been amplified from salivary swabs from cats, dogs and humans, we are not aware of studies investigating antibodies in oral fluid (OF). Using inhouse and commercial immunofluorescence antibody assays (IFA), the objective of this study was to detect and compare antibodies against in paired OF and serum specimens from cats. Read More

Jpn J Ophthalmol 2021 Apr 2. Epub 2021 Apr 2.

Department of Ophthalmology and Visual Science, Kochi Medical School, Kochi University, Kohasu, Oko-cho, Nankoku City, Kochi, 783-8505, Japan.

Purpose: To evaluate intraocular inflammation in Japanese patients with cat-scratch disease (CSD).

Study Design: Retrospective clinical chart review.

Patients And Methods: The cases of 15 consecutive patients (19 affected eyes) in Kochi Prefecture, Japan who were serologically positive for Bartonella henselae or Bartonella quintana infection in association with intraocular inflammation were reviewed. Read More

J Clin Exp Hepatol 2021 Mar-Apr;11(2):260-263. Epub 2020 Jul 25.

Departments of Radiodiagnosis, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, 110029, India.

Liver rupture in pregnancy is an acute condition with significant risk to the mother and fetus. It is known to occur with tumors such as hepatic adenoma, infective causes such as abscess, granulomatous diseases, and parasitic infections, and rarely spontaneously. Most of these conditions have overlapping clinicoradiological findings, almost always requiring histopathological confirmation. Read More

Vector Borne Zoonotic Dis 2021 Jun 15;21(6):413-421. Epub 2021 Mar 15.

Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.

Recently, infections with emerging zoonotic bacteria of the genus have been reported in association with a range of central nervous system (CNS) symptoms. Currently, it remains unknown if spp. infection is associated with symptoms of schizophrenia/schizoaffective disorder (SCZ/SAD). Read More

Cureus 2021 Feb 8;13(2):e13219. Epub 2021 Feb 8.

Internal Medicine, Hamad Medical Corporation, Doha, QAT.

Infection with ,a gram-negative coccobacillus, most frequently presents as cat-scratch disease (CSD) and often accompanies a recent history of cat bite or scratch. As compared to adults, teenagers and children or immunocompromised patients are predominantly affected by CSD. In immunocompetent individuals, CSD is typically a self-limiting clinical syndrome with complete resolution of febrile illness in two to four weeks with or without antimicrobial therapy. Read More

N Engl J Med 2021 03 6;384(10):952. Epub 2021 Mar 6.

University of Auckland School of Medicine, Auckland, New Zealand

Acta Microbiol Immunol Hung 2021 Mar 2. Epub 2021 Mar 2.

3Department of Bioistatistic, Faculty of Medicine, Medeniyet University, Istanbul, Turkey.

Bartonella henselae is the causative agent of cat scratch disease (CSD). In this study, we aimed to investigate the clinical data of patients with suspicion of CSD and delineate current epidemiological features.A total of 785 patients with suspected CSD were included in the study. Read More

Trop Biomed 2020 Dec;37(4):919-931

Department of Biological Sciences and Biotechnology, Faculty of Science and Technology, Universiti Kebangsaan Malaysia, 43600 UKM Bangi, Selangor, Malaysia.

Bacteria of the genus Bartonella have been known as emerging zoonotic pathogens for several human diseases including cat scratch disease, Carrion's disease and trench fever. Numerous species of small mammals have been reported to play a role as a suitable reservoir to many pathogenic Bartonella. These infections are thought to be transmitted through blood-feeding arthropod vectors such as ticks, fleas and lice. Read More

Pril (Makedon Akad Nauk Umet Odd Med Nauki) 2020 Dec 8;41(3):71-75. Epub 2020 Dec 8.

University Clinic for Infectious Diseases and Febrile Conditions, Faculty of Medicine "Ss. Cyril and Methodius", Skopje, Republic of North Macedonia.

Cat scratch disease (CSD) is the main clinical manifestation caused by Bartonella henselae in immuno-competent patients. The bacterium is transmitted to humans from cats via scratches or bites. In this case report, we are presenting to our knowledge the first etiologically confirmed case of CSD in our country. Read More

Arch Argent Pediatr 2021 02;119(1):e84-e87

Unidad 6 de Clínica Pediátrica, Hospital de Niños Ricardo Gutiérrez, Ciudad Autónoma de Buenos Aires.

Cat-scratch disease is produced by the bacterium Bartonella henselae, a gram-negative bacillus transmitted through cutaneous inoculation by a cat or dog's scratch or bite. It has a wide clinical spectrum, from a typical picture characterized by a regional lymphadenopathy near to the inoculation site to atypical pictures with systemic compromise. Bone compromise is infrequent, it represents around 0. Read More

Ned Tijdschr Tandheelkd 2021 Jan;128(1):21-27

Cat scratch disease is a usually harmless infectious disease caused by Bartonella henselae bacteria. These bacteria are transmitted to humans by a cat scratch or bite. Its typical presentation is a self-limiting lymphadenitis of regional lymph nodes, mostly in the neck. Read More

N Z Med J 2021 01 15;134(1528):96-98. Epub 2021 Jan 15.

MB., B.Chir., FRANZCO; Palmerston North Eye Department, MidCentral District Health Board.

Cat-scratch disease (CSD) is a systemic illness caused by the gram-negative bacteria Bartonella henselae (B. henselae). Cats serve as the primary host reservoir for B. Read More

Rev Chilena Infectol 2020 Aug;37(4):463-469

Departamento de Enfermedades Infecciosas e Inmunología Pediátrica, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile.

Bartonella henselae is cat scratch disease's etiological agent, which is considered an endemic infection in Chile. It typically presents as a self-limited regional lymphadenopathy and less frequently with systemic involvement and extranodal or atypical manifestations: hepatosplenic, ocular or musculoskeletal involvement, among others. We present three cases of atypical cat scratch disease with ocular compromise, as neurorretinitis. Read More

Turk J Ophthalmol 2020 12;50(6):371-376

University Sains Malaysia School of Medical Sciences, Department of Internal Medicine, Kelantan, Malaysia.

is a recognized cause of neuroretinitis in cat scratch disease. Meanwhile, polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, skin changes (POEMS) syndrome with Castleman disease (evidence of lymph node hyperplasia), is a chronic debilitating condition that predisposes to various superimposed infections. neuroretinitis implicated in POEMS syndrome has not been reported previously. Read More