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Neonatology 2019 Jan 15;115(3):205-210. Epub 2019 Jan 15.

Division of Neonatology, Department of Pediatrics, Leiden University Medical Center, Leiden, The Netherlands.

Background: Migration of umbilical venous catheters (UVCs) has been described anecdotally.

Objectives: The aim of this paper was to investigate migration of UVCs using ultrasonography (US).

Methods: In a prospective observational study, the position of UVCs was determined using serial US within 24 h, at midweek, and at the end of the week after umbilical catheterization. Read More

J Pediatr Gastroenterol Nutr 2019 Mar;68(3):384-388

Department of Surgery, University of Minnesota, Masonic Children's Hospital, Minneapolis, MN.

Purpose: Extrahepatic portal vein obstruction (EHPVO) is the most frequent cause of portal hypertension in children. Some patients are not amenable to meso-Rex bypass and alternative surgeries do not restore physiologic flow. We aim to demonstrate the feasibility and safety of minilaparotomy for recanalization of chronic EHPVO. Read More

Turk J Pediatr 2018 ;60(2):191-193

Division of Pediatric Cardiology, Departmant of Pediatrics, Dicle University Faculty of Medicine, Diyarbakır, Turkey.

Akın A, Bilici M, Demir F, Yılmazer MM, İpek MŞ, Kara H. Percutaneous retrieval of umbilical vein catheter fragment in an infant two months after embolization. Turk J Pediatr 2018; 60: 191-193. Read More

Turk J Pediatr 2018 ;60(1):113-115

Departments of Interventional Radiology, Başkent University Faculty of Medicine, Ankara, Turkey.

Varan B, Yakut K, Harman A. Transcatheter retrieval of embolized catheter using venovenous loop in a neonate. Turk J Pediatr 2018; 60: 113-115. Read More

Dis Model Mech 2018 06 22;11(6). Epub 2018 Jun 22.

Reference and Translation Center for Cardiac Stem Cell Therapy, Rostock University Medical Center, 18055 Rostock, Germany.

Ischemic heart failure is the leading cause of mortality worldwide. An early boost of intracardiac regenerative key mechanisms and angiogenetic niche signaling in cardiac mesenchymal stem cells (MSCs) could improve myocardial infarction (MI) healing. Epicardial erythropoietin (EPO; 300 U kg) was compared with intraperitoneal and intramyocardial EPO treatments after acute MI in rats (=156). Read More

Radiology 2018 05;287(2):719-724

From the Mallinckrodt Institute of Radiology, Washington University School of Medicine, 510 S Kingshighway Blvd, Campus Box 8131, St Louis, MO 63110.

History A 3-month-old previously healthy girl presented to an outside institution with a 4-day history of low-grade fever, irritability, and a tender "knot" in the upper abdomen. Ultrasonography (US) was performed at an outside hospital. US images were not available for review; however, they showed a mass in the left hepatic lobe, per the outside report, and the patient was referred to our institution for further evaluation. Read More

BMJ Case Rep 2018 Apr 17;2018. Epub 2018 Apr 17.

Department of Pediatrics, Post Graduate Institute of Medical Education and Research, Chandigarh, India.

A preterm neonate born at 27 weeks, with a birth weight of 555 g, was on continuous positive airway pressure (CPAP) for apnoea of prematurity and initially received total parenteral nutrition (TPN) through the umbilical venous catheter. Peripherally inserted central catheter (PICC) was inserted in the left basilica vein on day 8 to continue TPN. The baby developed respiratory distress with persistent hypoxia after TPN was initiated through the PICC line. Read More

Int J Artif Organs 2018 Jul 22;41(7):393-399. Epub 2018 Mar 22.

1 Division of Neonatology, Department of Pediatrics, McMaster University, Hamilton, ON, Canada.

Introduction: A lung assist device, which acts as an artificial placenta, can provide additional gas exchange for preterm and term newborns with respiratory failure. The concept of the lung assist device requires a large bore access via umbilical vessels to allow pumpless extracorporeal blood flow rates up to 30 mL/kg/min. After birth, constricted umbilical vessels need to be reopened for vascular access. Read More

Arch Dis Child Fetal Neonatal Ed 2019 Mar 17;104(2):F165-F169. Epub 2018 Mar 17.

Newborn Research Centre, The Royal Women's Hospital, Parkville, Victoria, Australia.

Introduction: Umbilical venous catheter (UVC) placement is a common neonatal procedure. It is important to position the UVC tip accurately at the first attempt to prevent complications and minimise handling. Catheters positioned too low need to be removed, but catheters positioned too high may be withdrawn in a sterile fashion to a safe position. Read More

Pediatr Crit Care Med 2018 Apr;19(4):332-338

Centre for the Studies of Asphyxia and Resuscitation, Neonatal Research Unit, Royal Alexandra Hospital, Edmonton, Alberta Health Services, Canada.

Objective: During neonatal cardiopulmonary resuscitation, early establishment of vascular access is crucial. We aimed to review current evidence regarding different routes for the administration of medications during neonatal resuscitation.

Data Sources: We reviewed PubMed, EMBASE, and Google Scholar using MeSH terms "catheterization," "umbilical cord," "delivery room," "catecholamine," "resuscitation," "simulation," "newborn," "infant," "intraosseous," "umbilical vein catheter," "access," "intubation," and "endotracheal. Read More

J Biomed Nanotechnol 2016 Dec;12(12):2185-01

The aim of this study was to investigate the anti-inflammatory effects and mechanism of action of the gold nanoparticles (AuNPs) on vascular injury. In vitro vascular endothelial cell (EC) inflammation and in vivo rat carotid balloon injury models were used. The expression of TNF-α-induced cell adhesion molecules (CAMs) was suppressed by the AuNPs in human umbilical vein ECs and aortic ECs. Read More

J Vasc Surg Cases Innov Tech 2017 Dec 2;3(4):218-220. Epub 2017 Nov 2.

Section of Pediatric Surgery, Department of Surgery, Yale University School of Medicine, New Haven, Conn.

A 43-day-old boy presented with bacteremia after umbilical artery catheterization. Duplex ultrasound examination revealed a 1.1- × 1. Read More

Resuscitation 2018 Jan 26;122:e21-e22. Epub 2017 Nov 26.

Division of Neonatology, Department of Paediatrics and Adolescent Medicine, Medical University of Graz, Graz, Austria.

Front Pediatr 2017 5;5:211. Epub 2017 Oct 5.

Pediatric and Neonatal Intensive Care Unit, Paris South University Hospitals, Le Kremlin-Bicêtre, Assistance Publique Hôpitaux de Paris, Paris, France.

The correct choice of intra vascular access in critically ill neonates should be individualized depending on the type and duration of therapy, gestational and chronological age, weight and/or size, diagnosis, clinical status, and venous system patency. Accordingly, there is an ongoing demand for optimization of catheterization. Recently, the use of ultrasound (US)-guided cannulation of the subclavian vein (SCV) has been described in children and neonates. Read More

Clin Anat 2018 Mar 31;31(2):269-274. Epub 2017 Oct 31.

Institute of Anatomy II, University of Cologne, Cologne, 50926, Germany.

Umbilical cord catheters (UCC) are important for the primary care of critically ill newborns. To analyze anatomical variations of the umbilical vein (UV) and its further course, we performed abdominal spiral-CT examinations on stillborns. The aim of the study was to explore the high incidence of mal-positioned UCCs and to improve their positioning. Read More

J Ultrasound Med 2018 Jun 16;37(6):1335-1344. Epub 2017 Oct 16.

Departments of Neonatology, Gazi University Faculty of Medicine, Ankara, Turkey.

Objectives: Umbilical venous catheterization is commonly used in the neonatal period; however, it has some complications. In this study, we evaluated neonates who underwent umbilical venous catheterization and developed hepatic complications. Furthermore, we aimed to define all of the possible lesions and to clarify the imaging findings of umbilical venous catheter-induced hepatic injury. Read More

Cochrane Database Syst Rev 2017 10 10;10:CD012142. Epub 2017 Oct 10.

Neonatology, Royal Prince Alfred Hospital, Missenden Road, Camperdown, Sydney, NSW, Australia, 2050.

Background: Lengthy duration of use may be a risk factor for umbilical venous catheter-associated bloodstream infection in newborn infants. Early planned removal of umbilical venous catheters (UVCs) is recommended to reduce the incidence of infection and associated morbidity and mortality.

Objectives: To compare the effectiveness of early planned removal of UVCs (up to two weeks after insertion) versus an expectant approach or a longer fixed duration in preventing bloodstream infection and other complications in newborn infants. Read More

J Pediatr Hematol Oncol 2018 03;40(2):e64-e68

Department of Pediatrics, Division of Neonatology, Leiden University Medical Center, Leiden.

Central venous catheters (CVCs) in neonates are associated with an increased risk of thrombosis. Most reports focus on umbilical venous catheters (UVCs) and peripherally inserted central catheters (PICCs), whereas data available on femoral venous catheters (FVCs) are limited. We performed a retrospective cohort study in all neonates (gestational age ≥34 wk) with CVCs. Read More

Fetal Diagn Ther 2018 11;43(1):77-80. Epub 2017 Aug 11.

Department of Obstetrics and Gynaecology, Sarawak General Hospital, Kuching, Malaysia.

We illustrate a case of giant placental chorioangioma presenting at 20 weeks of gestation. Subsequent monitoring revealed enlargement of the lesion, associated with fetal anemia and cardiac failure, prompting in utero intervention. Amnioreduction followed by percutaneous embolization of the tumour with enbucrilate:Lipiodol Ultra-Fluid™ at a dilution of 1:5 was successfully performed. Read More

Pol J Radiol 2017 16;82:320-321. Epub 2017 Jun 16.

Department of Radiology, Gazi University, Faculty of Medicine, Ankara, Turkey.

Background: Absent ductus venosus (ADV) is a rare condition, but it should be known that this embryonic anomaly may be detected by fetal echocardiographic or newborn ultrasound examinations.

Case Report: We present a baby with an ADV and an accompanying alternative porto-caval shunt between the right portal vein and inferior vena cava detected on postnatal ultrasound examination.

Conclusions: Variations in the fetal umbilical or porto-systemic circulations should be detected by fetal or newborn ultrasound examinations and kept in mind before common interventions such as UV catheterizations. Read More

Pediatr Dev Pathol 2017 Jun 25;20(3):251-254. Epub 2017 Jan 25.

4 Department of Surgery, Marshfield Clinic, Marshfield, Wisconsin, USA.

Presented is a case of a hepatic calcified mass complicating umbilical vein catheterization in a neonate and diagnosed by wedge biopsy. Wedge biopsy of the hepatic mass, situated in proximity to the falciform ligament, revealed expansion of portal tracts by fibrosis and calcification. Some aggregates of calcified material appeared in ectatic vascular spaces. Read More

Turk Pediatri Ars 2017 Mar 1;52(1):35-42. Epub 2017 Mar 1.

Department of Pediatrics, Division of Neonatology, Karadeniz Technical University School of Medicine, Trabzon, Turkey.

Aim: Central venous access is frequently provided by way of umbilical venous catheter placement in critically ill newborns. This study compared the methods of Dunn, Shukla-Ferrara, and Revised Shukla-Ferrara in determining the appropriate insertion length of umbilical vein catheters.

Material And Methods: This prospective observational study was carried out in 121 newborns with umbilical venous catheter, group 1 (n=41) used Dunn method, group 2 (n=40) used the Shukla-Ferrara formula, and group 3 used revised Shukla-Ferrara formula (n=40). Read More

Arch Dis Child Fetal Neonatal Ed 2017 May 18;102(3):F251-F255. Epub 2016 Oct 18.

Department of Pediatrics, Section of Neonatology, Cumming School of Medicine, Calgary, Alberta, Canada.

Objectives: To evaluate the umbilical venous catheter (UVC) tip position by ultrasound and compare it with standard radiograph findings and to examine the catheter tip migration rates during the first week of life.

Design: Prospective observational study of inborn preterm infants who had an UVC placed and its position radiographically confirmed. The first ultrasound was done on UVC placement at median (IQR) age of 2 hours (1-4) and follow-up scans at a median (IQR) age of 34 hours (27-44 hours), 77 hours (70-94 hours) and 6 days (5-7 days) after insertion. Read More

J Neonatal Perinatal Med 2017 ;10(1):55-61

Department of Pediatrics, Stony Brook University Hospital, Stony Brook, NY, USA.

Objective: To compare chest X-ray with echocardiogram (ECHO) in the localization of an umbilical venous catheter (UVC) tip in very low birth weight infants (VLBW). Secondary objectives determined the association between techniques for tip placement by the vertebral body level on X-ray, as well as the length of the thoracic inferior vena cava-right atrial (TIVC-RA) junction by ECHO.

Study Design: Prospective, sequentially enrolled, masked, single regional perinatal center study. Read More

Mol Med Rep 2017 Apr 22;15(4):2213-2222. Epub 2017 Feb 22.

Department of Cardiology/Cardiac Catheterisation Lab, Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, P.R. China.

The inhibitory effects of hydrogen sulfide (H2S) on angiotensin II (AngII)-stimulated human umbilical vein endothelial cell (HUVEC) dysfunction remain to be elucidated. Endoplasmic reticulum (ER) stress has been detected in endothelial dysfunction (ED). The present study aimed to determine whether H2S may exert an inhibitory effect on AngII‑induced ER stress. Read More

Surg Innov 2017 Jun 13;24(3):223-232. Epub 2017 Feb 13.

4 Clinical Nephrology Hospital Carol Davila, University of Medicine and Pharmacy "Carol Davila", Bucharest, Romania.

Aim: The aim of this article was to report a new transomphalic extraperitoneal surgical technique for treatment of hydrocephalus, called ventriculoportal shunt.

Materials And Methods: We performed ventriculoportal shunt on an experimental animal (pig). The particularity of ventriculoportal shunt consists in the fact that the distal end of the catheter is inserted transomphalic extraperitoneally in the portal system through reopened umbilical vein. Read More

Radiol Med 2017 May 10;122(5):386-391. Epub 2017 Feb 10.

Section of Radiological Sciences, DIBIMED, University of Palermo, Via del Vespro 127, 90127, Palermo, Italy.

Background: Umbilical Venous Catheter (UVC) are commonly used in neonatal period; they can be not correctly positioned and could be associated with complications. The purpose of this article is to suggest a flow-chart to evaluate the placement of UVC, testing it in young radiologists-in-training.

Method: We developed a simple flow-chart to asses, steps by step, UVC placement considering its course and tip location (ideally placed in the atriocaval junction). Read More

Pediatr Crit Care Med 2017 02;18(2):172-175

1Pediatric and Neonatal Intensive Care Unit, Paris South University Hospitals, Assistance Publique Hôpitaux de Paris, Le Kremlin-Bicêtre, Paris, France. 2School of Medicine, Paris South University, Le Kremlin-Bicêtre, Paris, France. 3Institute of Integrative Biology of the Cell-UMR 9198, Paris Saclay University, Gif-sur-Yvette, Paris, France. 4Espace Ethique/IDF, Saint Louis University Hospital, Assistance Publique Hôpitaux de Paris, Paris, France.

Objectives: Central venous access in critically ill, small infants remains technically challenging even in experienced hands. Several vascular accesses exist, but the subclavian vein is often preferred for central venous catheter insertion in infants where abdominal malformation and/or closure of the vein preclude the use of umbilical venous catheters, as catheterization of the subclavian vein is easier in very short necks than the internal jugular vein for age-related anatomical reasons. The subclavian vein approach is yet relatively undescribed in low birth weight infants (i. Read More

Pan Afr Med J 2016 20;25:13. Epub 2016 Sep 20.

Department of Intensive Care and Neonatal Medicine, Teaching Hospital of Monastir, Tunisia.

With more and more extreme premature and very low-birth weight babies being resuscitated, umbilical central venous catheterisation is now being used more frequently in neonatal intensive care. One of the life-threatening complications is pericardial effusion and cardiac tamponade; however, it is potentially reversible when it is caught in time. The authors present a case of cardiac tamponade following umbilical venous catheterisation in a neonate. Read More

Neonatology 2017 17;111(4):337-343. Epub 2017 Jan 17.

Department of Surgery, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.

Objective: The etiology of necrotizing enterocolitis (NEC) remains elusive despite known associations with several factors, including intestinal ischemia related to the effects of umbilical arterial catheterization on the mesenteric circulation. However, the role of the mesenteric venous circulation has yet to be studied as a potential cause of NEC. We examined the association between umbilical venous catheter (UVC) position and the development of NEC in premature infants. Read More

J Perinatol 2017 04 12;37(4):409-413. Epub 2017 Jan 12.

Department of Pediatrics, Washington University in St. Louis, St. Louis, MO, USA.

Objective: Our objective was to safely reduce the number of peripherally inserted central catheters (PICCs) inserted in infants with umbilical venous catheter using quality improvement methods.

Study Design: In a tertiary neonatal intensive care unit, a questionnaire designed to prompt critical thinking around the decision to place a PICC, along with an updated standardized feeding guideline was introduced. PICC insertion in 86 infants with umbilical venous catheter (pre intervention) with birth weight 1000-1500 g were compared with 115 infants (post intervention) using Fisher's exact test. Read More

J Trop Pediatr 2017 10;63(5):374-379

Department of Physiology, Pramukhswami Medical College, Karamsad, Gujarat 388325, India.

Peripherally inserted central catheter (PICC) and umbilical venous catheter (UVC) in terms of success rate, complications, cost and time of insertion in neonatal intensive care were compared. Neonates requiring vascular access for minimum 7 days were included. Sample size of 72 per group was determined. Read More

Turk Kardiyol Dern Ars 2016 Dec;44(8):700-702

Department of Child Health and Diseases, Acıbadem University Faculty of Medicine, İstanbul, Turkey.

A 28-week-old preterm infant with a birth weight of 1250 g had a broken segment of umbilical vein catheter (UVC) lodged in the right atrium. It was observed that a 7-cm fragment of catheter had migrated to the right atrium through the inferior vena cava. The catheter was successfully retrieved by fluoroscopically guided percutaneous cardiac catheterization, using a cobra catheter and snare wire, without complication. Read More

Arch Argent Pediatr 2016 Dec;114(6):e429

Department of Pediatric Surgery, Katip Celebi University Faculty of Medicine, Izmir, Turkey.

Umbilical venous catheterization has become a widely accepted intravenous route for premature babies. These catheters allow administration of parenteral nutrition and medication and facilitate blood sampling. Besides these benefits, they also have significant potential complications like portal vein thrombosis, infection, vascular or hepatic injury, arrhythmia and sepsis. Read More

Case Rep Gastrointest Med 2016 5;2016:8602378. Epub 2016 Oct 5.

Department of Surgery Named after N. D. Monastyrskiy, North-Western State Medical Academy Named after I. I. Mechnikov, Saint Petersburg, Russia.

Portal biliopathy is the complex of abnormalities of extrahepatic and intrahepatic bile ducts, cystic duct, and gallbladder, arising as a result of extrahepatic portal vein obstruction and noncirrhotic portal fibrosis, which can be caused by coagulopathies, tumors, inflammation, postoperative complications, dehydration, and neonatal umbilical vein catheterization. We report a case of a 55-year-old male patient with the history of pancreatic cancer and cholecystoenteric anastomosis presenting with gastrointestinal bleeding from gallbladder varices via the anastomosis. Read More

Mol Med Rep 2016 Nov 12;14(5):4729-4740. Epub 2016 Oct 12.

Department of Cardiology/Cardiac Catheterization Laboratory, Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, P.R. China.

The effects of hydrogen sulfide (H2S) and the nuclear factor κB (NF-κB) signaling pathway in angiotensin II (AngII)-induced endothelin-1 (ET-1) expression and subsequent cytotoxicity remain unclear. The present study aimed to investigate the hypothesis that H2S protects human umbilical vein endothelial cells (HUVECs) against AngII‑stimulated ET‑1 generation and subsequent cytotoxicity‑induced endoplasmic reticulum stress via the NF‑κB signaling pathway. The results of the present study demonstrated that AngII significantly upregulated the expression levels of ET‑1, glucose‑regulated protein 78, CCAAT‑enhancer‑binding protein homologous protein, phosphorylated (p)‑p65 and inducible nitric oxide synthase; stimulated nitric oxide production; suppressed the expression and activity of cystathionine-γ-lyase (CSE), a H2S synthetase; and decreased cell viability. Read More

Glob Pediatr Health 2016 12;3:2333794X16670494. Epub 2016 Oct 12.

Texas Tech University Health Sciences Center, Amarillo, TX, USA.

We report a rare, but serious, complication of a malpositioned umbilical venous catheter in a term male infant who developed laceration, hematoma, and necrosis of liver, ascites, and left-sided obstructive uropathy secondary to extravasation of total parenteral nutrition. Abdominal paracentesis confirmed the presence of parenteral nutrition in the peritoneal cavity. Although, the umbilical venous catheterization is a common intravenous access used in neonatal intensive care units, judicious continued monitoring of its use should be practiced to avoid serious complications. Read More

Case Rep Urol 2016 26;2016:1425373. Epub 2016 Sep 26.

College of Medicine, University of Central Florida, 6850 Lake Nona Blvd, Orlando, FL 32827, USA; Pediatric Urology, Arnold Palmer Children's Hospital, 92 W. Miller St, Orlando, FL 32806, USA.

Iatrogenic bladder injuries have been reported in the neonate during umbilical artery/vein catheterization, voiding cystourethrogram, urinary catheterizations, and overwhelming hypoxic conditions. Patients with iatrogenic bladder perforations can present with acute abdomen indicating urinary peritonitis, septic-uremic shock, or subtle symptoms like abdominal distension, pain, hematuria, uremia, electrolyte imbalances, and/or difficulty urinating. The following neonatal case report of perforated bladder includes a review of the signs, symptoms, diagnostic tools, and management of bladder injury in neonates. Read More

J Gastrointestin Liver Dis 2016 Sep;25(3):395-9

Iuliu Hațieganu University of Medicine and Pharmacy; Prof. Dr. Octavian Fodor Regional Institute of Gastroenterology and Hepatology, Cluj-Napoca, Romania.

Although transjugular intrahepatic portosystemic shunts are most frequently used for the management of portal hypertension, the surgical approach is preferred for symptomatic portal cavernoma cholangiopathy. We present the case of a 25-year old female patient with a portal cavernoma secondary to catheterization of the umbilical vein at birth. She had had two episodes of esophageal variceal bleeding, successfully treated by endoscopic banding. Read More

Cardiovasc Res 2016 12 26;112(3):689-701. Epub 2016 Sep 26.

Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield S10 2RX, UK

Aims: Stent deployment causes endothelial cells (EC) denudation, which promotes in-stent restenosis and thrombosis. Thus endothelial regrowth in stented arteries is an important therapeutic goal. Stent struts modify local hemodynamics, however the effects of flow perturbation on EC injury and repair are incompletely understood. Read More

Turk Kardiyol Dern Ars 2016 Sep;44(6):521-3

Department of Pediatric Cardiology, İstanbul University, İstanbul Faculty of Medicine, İstanbul, Turkey.

Balloon valvuloplasty is an effective therapy for severe congenital aortic valve stenosis, with mild aortic insufficiency and minimal intermediate-term restenosis. No consensus currently exists regarding optimal vascular approach for balloon dilatation in newborns with critical or severe aortic valve stenosis. Critical aortic valve stenosis in newborns must be treated promptly and effectively. Read More

J Perinat Med 2017 Feb;45(2):227-236

Objective: To determine if intrauterine intraumbilical supplementation with amino acids (AA) and glucose can improve neonatal outcome of severe growth restricted human fetuses (IUGR).

Methods: Prospective pilot study of intrauterine treatment of severe IUGR fetuses [n=14, 27 weeks of gestation (range 23-31)] with cerebroplacental ratio <1, with long-term intraumbilical AA and glucose supplementation (10% of feto-placental blood volume/day) using a perinatal port system alone (n=5) or combined with hyperbaric oxygenation (n=1, HBO) vs. control group (n=8). Read More

WMJ 2016 08;115(4):180-4

Background: Neonatal resuscitations and significant adverse cardiorespiratory events during pediatric sedations are infrequent. Thus, it is challenging to maintain the skills necessary to manage patients experiencing these events. As the pediatric emergency medicine specialty expands, exposure of general emergency medicine physicians to these potentially critical patients may become even more limited. Read More

Clin Ter 2016 May-Jun;167(3):80-1

Department of Radiology, Pediatric Radiology, Meyer Children's University Hospital, Florence.

The use of umbilical venous catheter (UVC) is common practice in neonatal units. The traumatic injury of the hepatic parenchyma is a rare complication. We present a case of a preterm newborn underwent ultrasound examination revealing a hyperechogenic focal lesion at the confluence of the hepatic veins This finding, according to patient's history, was suspected to be a traumatic injury of the liver parenchyma caused by umbilical catheterization. Read More

J Pediatr (Rio J) 2017 Mar - Apr;93(2):172-178. Epub 2016 Jul 15.

Universidade Federal de Minas Gerais (UFMG), Hospital das Clínicas, Belo Horizonte, MG, Brazil; Universidade Federal de Minas Gerais (UFMG), Departamento de Pediatria, Belo Horizonte, MG, Brazil.

Objectives: To evaluate the accuracy of the simultaneous analysis of three radiographic anatomical landmarks - diaphragm, cardiac silhouette, and vertebral bodies - in determining the position of the umbilical venous catheter distal end using echocardiography as a reference standard.

Methods: This was a cross-sectional, observational study, with the prospective inclusion of data from all neonates born in a public reference hospital, between April 2012 and September 2013, submitted to umbilical venous catheter insertion as part of their medical care. The position of the catheter distal end, determined by the simultaneous analysis of three radiographic anatomical landmarks, was compared with the anatomical position obtained by echocardiography; sensitivity, specificity, positive predictive value, negative predictive value, and accuracy were calculated. Read More

Acta Paediatr 2016 Oct 12;105(10):e443-7. Epub 2016 Aug 12.

Department of Neonatology, The National Maternity Hospital, Dublin, Ireland.

Aim: Newborns are placed supine for umbilical venous catheter insertion, and catheter tip position is confirmed with X-ray. Umbilical venous catheters are considered correctly positioned when the tip is in the inferior vena cava; however, frequently, the catheter tip enters the portal venous circulation. We wished to determine whether placing infants on their right side, rather than on the back, for umbilical venous catheter insertion results in more correctly placed catheters. Read More

BMJ Case Rep 2016 Jun 22;2016. Epub 2016 Jun 22.

Duke - NUS Medical School, Singapore NUS YLL School of Medicine, Singapore Department of Neonatology and Diagnostic and Interventional Imaging, KK Women's and Children's Hospital, Singapore.

Toxicol Appl Pharmacol 2016 08 14;305:194-202. Epub 2016 Jun 14.

The Ph.D. Program for Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei 11031, Taiwan; Department of Pharmacology, College of Medicine, Taipei Medical University, Taipei 10031, Taiwan. Electronic address:

Purpose: Vascular smooth muscle cell (VSMC) proliferation plays a critical role in the pathogenesis of atherosclerosis and restenosis. This study investigated piperazinedione derived compound TW-01-mediated inhibitory effects on VSMC proliferation and intimal hyperplasia.

Methods: Cell proliferation was determined using [(3)H]-thymidine incorporation and MTT assay; cell cycle distribution was measured using flow cytometry; proteins and mRNA expression were determined using western blotting and RT-PCR analyses; DNA binding activity of nuclear factor-κB (NF-κB), as measured using enzyme-linked immunosorbent assays (ELISA); in vivo effects of TW-01 were determined using balloon angioplasty in the rat. Read More

Arterioscler Thromb Vasc Biol 2016 08 9;36(8):1534-48. Epub 2016 Jun 9.

From the Department of Molecular Medicine, A.I. Virtanen Institute, University of Eastern Finland, Kuopio, Finland (J.H., S.Y.-H.); Centre for R&D, Uppsala University/County Council of Gaevleborg, Gaevle, Sweden (O.L.); Institute for Pathology, University Clinic of Schleswig-Holstein, Campus Kiel, Kiel, Germany (J.H.B.); Max-Delbrück Center for Molecular Medicine, Berlin, Germany (W.-H.S., D.M., A.H., J.-D.D., L.T., F.B.); Department of Cardiology (B.P., F.B.) and Center for Cardiovascular Research/CCR, Institute of Laboratory Medicine Clinical Chemistry and Pathobiochemistry (K.K.), Charité-Universitaetsmedizin Berlin, Berlin, Germany; Institute of Biomaterial Science and Berlin-Brandenburg Centre for Regenerative Therapies (BCRT), Helmholtz-Zentrum Geesthacht, Teltow, Germany (F.J., C.M.); Institute for Diabetes and Obesity, Helmholtz Zentrum Muenchen, Munich, German Research Center for Environmental Health, Germany (M.J.); and Cologne Interventional Immunology, University Hospital of Cologne, Cologne, Germany (M.v.B.-B.).

Objective: Drug-eluting coronary stents reduce restenosis rate and late lumen loss compared with bare-metal stents; however, drug-eluting coronary stents may delay vascular healing and increase late stent thrombosis. The peroxisome proliferator-activated receptor-delta (PPARδ) exhibits actions that could favorably influence outcomes after drug-eluting coronary stents placement.

Approach And Results: Here, we report that PPARδ ligand-coated stents strongly reduce the development of neointima and luminal narrowing in a rabbit model of experimental atherosclerosis. Read More

Ugeskr Laeger 2016 May;178(22)

A seven-year-old boy was admitted with haematemesis. The boy was originally born at 27 weeks' gestational age. His neonatal period had been complicated by sepsis, for which he was treated with antibiotics through an umbilical venous catheter (UVC). Read More