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Curr Med Imaging 2022 Jun 20. Epub 2022 Jun 20.

Department of Radiology, Faculty of Medicine, Bezmialem Vakif University, Istanbul, Turkey.

Background: Umbilical vein catheterization (UVC) is an early venous access route in newborns and is frequently used for delivering total parenteral nutrition (TPN) and medications. Vascular, hepatic parenchymal, and infectious complications of UVC can be seen rarely.

Objective: We present preterm neonates' X-ray, US, and MRI findings with parenchymal TPN extravasation and portal vein thrombosis. Read More

J Pediatr 2022 05;244:e9

Department of Pediatric Research, University of Oslo, Oslo, Norway; Ann and Robert H. Lurie Children's Hospital of Chicago, Northwestern University Feinberg School of Medicine, Chicago, Illinois.

Vasc Endovascular Surg 2022 May 17;56(4):428-431. Epub 2022 Feb 17.

Department of Vascular Surgery, 4965The Royal Free London NHS Foundation Trust, London, UK.

Despite rare, retrieving detached umbilical venous catheter (UVC) remnants from central vessels in neonates is challenging due to their small body habitus and vessels with high risk of vascular injury and thrombosis and often associated comorbidities. We report a challenging surgical retrieval of a UVC remnant from the aorto-iliac artery of a pre-term neonate. An attempted UVC insertion into a pre-term neonate was complicated by misplacement and detachment of a 4 cm remnant into the infra-renal abdominal aorta and left iliac artery. Read More

J Ultrasound Med 2022 Jan 18. Epub 2022 Jan 18.

Department of Radiology, Haeundae Paik Hospital, Inje University, Busan, Korea.

Objectives: To identify sonographic findings that predict clinical outcomes in neonates with portal vein gas.

Methods: This retrospective study included neonates with portal vein gas detected using ultrasound (US). The US images were reviewed by a pediatric radiologist. Read More

Children (Basel) 2021 Nov 26;8(12). Epub 2021 Nov 26.

Division of Neonatology, Department of Pediatrics and Adolescent Medicine, Medical University of Graz, 8036 Graz, Austria.

Recent guidelines recommend the umbilical venous catheter (UVC) as the optimal vascular access method during neonatal resuscitation. In emergencies the UVC securement may be challenging and time-consuming. This experimental study was designed to test the feasibility of new concepts for the UVC securement. Read More

Children (Basel) 2021 Nov 5;8(11). Epub 2021 Nov 5.

Department of Pediatrics, National Cheng Kung University Hospital, College of Medicine, National Cheng-Kung University, Tainan 704302, Taiwan.

Cardiovascular catheterization has been applied in infant treatment for several decades. To date, considerable research attention has been paid to cardiovascular catheterization in small neonates. However, peripheral vascular routes of catheterization are possible obstacles for interventionists. Read More

BMJ Case Rep 2021 Nov 11;14(11). Epub 2021 Nov 11.

Newborn & Paediatric Emergency Transport Service, Sydney Children's Hospitals Network, Sydney, NSW, Australia

We describe a 9-day-old baby with coarctation of the aorta who required urgent resuscitation including intubation and cardiac compressions. Despite the commencement of prostaglandin E1 (PGE) to reopen the ductus arteriosus via the intraosseous route, postductal saturations remained unrecordable for a further 45 min. Within 3 min of administration of PGE via an umbilical venous catheter (UVC), saturations were recordable at 92%. Read More

Zhongguo Ying Yong Sheng Li Xue Za Zhi 2021 Jan;37(1):1-8

1. Department of Cardiology,Fuwai Hospital,Chinese Academy of Medical Sciences/National Center for Cardiovascular Diseases/ State Key Laboratory of Cardiovascular Diseases/Chinese Academy of Medical Sciences/Peking Union Medical College,Beijing 100037.

The fetus has no actual respiration, and the newborn begins to breathe after birth. We assume that the first breath dominantly generated by hypoxia. In this study, the changes and lowest limit of blood oxygen partial pressureof umbilical artery (PuaO) after chemoreceptor were analyzed to explore the mechanism of neonatal spontaneous breathing. Read More

Surg Clin North Am 2021 Oct 30;101(5):799-812. Epub 2021 Jul 30.

Division of Pediatric Surgery, Children's Hospital Los Angeles, 4650 Sunset Boulevard, Mailstop #100, Los Angeles, CA 90027, USA; Department of Surgery, Keck School of Medicine of the University of Southern California, Los Angeles, CA, USA; Department of Preventive Medicine, University of Southern California, Los Angeles, CA, USA. Electronic address:

This review discusses complications unique to pediatric surgical populations. Here the authors focus primarily on five of the most common procedures performed in children: appendectomy, central venous catheterization, pyloromyotomy, gastrostomy, and inguinal/umbilical hernia repair. Read More

BMJ Case Rep 2021 Sep 3;14(9). Epub 2021 Sep 3.

KK Women's and Children's Hospital, Singapore

We present a rare case of premature low birthweight neonate with right diaphragmatic hernia and transposition of great vessels requiring balloon atrial septostomy. Congenital diaphragmatic hernia poses a unique challenge to umbilical venous catheterisation. Based on the radiographic position of umbilical vein catheter, umbilical venous cannulation was attempted; however, the catheter could not be navigated to the right atrium. Read More

Medicine (Baltimore) 2021 Sep;100(35):e26774

The Department of Hepatology, the First People Hospital of JiuJiang, JiangXi, China.

Abstract: Umbilical Vein Recanalization (UVR) may occur in patients with long-standing portal hypertension and liver cirrhosis. This study aimed to investigate the clinical significance of UVR.Medical records of a cohort of patients with cirrhosis (n = 247) who were hospitalized at the Digestive Medicine Center of the Second Affiliated Hospital of Nanchang University from January 2012 to October 2015 were accessed. Read More

J Vasc Access 2021 Aug 8:11297298211034311. Epub 2021 Aug 8.

Pediatric and Neonatal Intensive Care Unit, Bicêtre Medical Centre, Paris Saclay University, AP HP, Le Kremlin Bicêtre, France.

Background: Umbilical Venous Catheter (UVC) and Epicutaneo-Caval Catheters (ECC) are reference catheters in the neonatal period. However, many factors such as the corpulence of neonates, poor venous capital, and anatomical variants can complicate ECC insertion or make it impossible. In newborns with failed ECC insertion, we developed an hybrid technique that combines the insertion of a long-lasting silicone or polyurethane small caliber catheter, usually used as a ECC in newborns, with the ease and speed of ultrasound guided puncture of the brachiocephalic vein (BCV). Read More

Insights Imaging 2021 Jul 27;12(1):109. Epub 2021 Jul 27.

Department of Pediatric Surgery, Guangzhou Women and Children's Medical Center, 9 Jinsui Road, Guangzhou, 510623, Guangdong, China.

Background: Extrahepatic portal vein obstruction (EHPVO) is the most important cause of hematemesis in children. Intrahepatic left portal vein and superior mesenteric vein anastomosis, also known as meso-Rex bypass (MRB), is becoming the gold standard treatment for EHPVO. We analyzed the value of preoperative computed tomography (CT) in determining whether MRB is feasible in children with EHPVO. Read More

J Perinatol 2021 10 16;41(10):2505-2512. Epub 2021 Jul 16.

Clinical and Health Sciences, Rosemary Bryant AO Research Centre, University of South Australia, Adelaide, SA, Australia.

Objective: To determine the incidence of adverse events (AEs) associated with umbilical catheters in the neonatal population.

Study Design: Systematic review and meta-analysis of observational studies and randomized controlled trials published between 2010 and 2020.

Results: In total 14,226 umbilical venous catheters (UVCs) and 4228 umbilical arterial catheters (UACs) were included. Read More

J Pediatr Gastroenterol Nutr 2021 Nov;73(5):642-646

Department of Pediatrics, Faculty of Medical Sciences, State University of Campinas (UNICAMP). Campinas, São Paulo, Brazil.

Objectives: The aim of this study was to describe long-term changes in standard blood tests and ultrasound (US) findings in pediatric patients with Extrahepatic Portal Vein Obstruction (EHPVO) who have not undergone Meso-Rex Bypass (MRB) surgery.

Methods: US, laboratory, and endoscopic data of 77 patients were analyzed and compared at 2 different points in time: at initial workup and at most recent follow-up. Differences were assessed using McNemar and Wilcoxon tests, while correlations were evaluated using generalized estimating equations. Read More

J Clin Med 2021 Jun 18;10(12). Epub 2021 Jun 18.

2nd Pediatric Discipline, Department of Mother and Child, Iuliu Hațieganu University of Medicine and Pharmacy, 400112 Cluj-Napoca, Romania.

One of the most important causes of portal hypertension among children is extrahepatic portal vein thrombosis (EHPVT). The most common risk factors for EHPVT are neonatal umbilical vein catheterization, transfusions, bacterial infections, dehydration, and thrombophilia. Our study aimed to describe the clinical manifestations, treatment, evolution, and risk factors of children with EHPVT. Read More

Pediatr Investig 2021 Jun 25;5(2):155-158. Epub 2021 Jan 25.

Neonatal Department Chengdu Women's and Children's Central Hospital School of Medicine University of Electronic Science and Technology of China Chengdu Sichuan China.

Introduction: Portal venous gas (PVG) is common in necrotizing enterocolitis and occasionally occurs in neonates after umbilical vein catheterization (UVC). Therefore, determining the cause of PVG requires further clinical evaluation in these cases.

Case Presentation: We report the case of a very-low-birth-weight infant who underwent UVC after birth. Read More

Andes Pediatr 2021 Feb 22;92(1):99-103. Epub 2021 Feb 22.

Clínica Alemana Santiago, Santiago, Chile.

Objective: To describe an innovative alternative to exploratory laparotomy in a newborn with a sub capsular hepatic hematoma secondary to umbilical vein catheterization.

Clinical Case: A preterm baby with a history of hyaline membrane disease, pulmonary hypertension, and large patent ductus arteriosus, requiring mechanical ventilation and the use of vasoactive drugs. Umbilical catheters were inserted and through an abdomen X-ray, we observed their proper position. Read More

J Perinatol 2021 07 8;41(7):1633-1637. Epub 2021 Jun 8.

Department of Pediatrics, Yale University School of Medicine, New Haven, CT, USA.

Objective: To develop a novel, rapid, and more accurate model for estimating umbilical arterial (UAC) and venous catheter (UVC) insertion length.

Study Design: We evaluated UACs and UVCs from a retrospective cohort to determine the rate of correct initial positioning based on conventional birth weight-based equations utilized in our neonatal intensive care unit. We then derived new equations, developed the mobile application, UmbiCalc, to simplify implementation of the new equations, and validated their accuracy with prospective utilization. Read More

CVIR Endovasc 2021 Jun 7;4(1):47. Epub 2021 Jun 7.

Department of Radiology - Papa Giovanni XXIII Hospital, University of Milano Bicocca, Piazza OMS 1, 24127, Bergamo, Italy.

Background: Anomalies of the portal venous system can be congenital or acquired, the latter being related to spontaneous thrombosis or iatrogenic alterations such as complications of perinatal catheterization of the umbilical vein. These conditions can be clinically silent for years and then manifest abruptly causing severe clinical emergencies.

Case Presentation: This case report describes the diagnosis and interventional management of a singular abnormality in the portal venous system of an 8-year-old female that led to severe portal hypertension and acute variceal bleeding. Read More

Pharm Res 2021 May 10;38(5):885-900. Epub 2021 May 10.

Division of Pharmacology and Pharmaceutics Sciences, University of Missouri-Kansas City, 2464 Charlotte Street, HSB-4242, Kansas City, MO, 64108, USA.

Purpose: This study aimed to develop personalized biodegradable stent (BDS) for the treatment of coronary heart disease. Three-dimensional (3D) printing technique has offered easy and fast fabrication of BDS with enhanced reproducibility and efficacy.

Methods: A variety of BDS were printed with 3 types of hydrogel (~5 ml) resources (10%w/v sodium alginate (SA), 10%w/v cysteine-sodium alginate (SA-CYS), and 10%w/v cysteine-sodium alginate with 0. Read More

Oman Med J 2021 Mar 31;36(2):e242. Epub 2021 Mar 31.

Department of Neonatology, Al Jalila Children's Specialty Hospital, Dubai, UAE.

Pleural effusion is an extremely rare complication in neonates after umbilical venous catheterization that can present with respiratory distress, a neonatal emergency. It needs timely intervention to reduce respiratory distress. We report an interesting and rare case where a term newborn developed right-sided pleural effusion after umbilical venous catheter (UVC) insertion and starting on total parenteral nutrition (TPN). Read More

J Paediatr Child Health 2022 Jan 19;58(1):197-198. Epub 2021 Mar 19.

Department of Radiology, Adıyaman University Training and Research Hospital, Adıyaman, Turkey.

Ital J Pediatr 2021 Mar 18;47(1):68. Epub 2021 Mar 18.

Neonatal Intensive Care Unit, Infermi Hospital, Rimini, AUSL of Romagna, Italy.

Background: Recent guidelines advocate the use of real-time ultrasound to locate umbilical venous catheter tip. So far, training programs are not well established.

Methods: A pre/post interventional study was carried out in our tertiary neonatal intensive care unit centre to evaluate the efficacy of a training protocol in the use of real-time ultrasound. Read More

Arch Dis Child Fetal Neonatal Ed 2021 Nov 9;106(6):578-583. Epub 2021 Mar 9.

Department of Pediatrics, University of California Davis, Sacramento, California, USA.

Objectives: Neonatal resuscitation guidelines recommend 0.5-1 mL saline flush following 0.01-0. Read More

Singapore Med J 2021 Jan 4;62(1):29-33. Epub 2019 Nov 4.

Department of Neonatal and Developmental Medicine, Singapore General Hospital, Singapore.

Introduction: Umbilical venous catheters (UVCs), commonly inserted in neonates for vascular access, are not without complications.

Methods: A single-centre retrospective cohort study that reviewed complications related to UVC insertion in neonates was conducted in a tertiary neonatal unit in Singapore from January 2016 to July 2017. Ideal UVC position was defined as catheter tip within 0. Read More

Arch Dis Child Fetal Neonatal Ed 2022 03 4;107(2):120. Epub 2021 Feb 4.

St Mary's Hospital, Neonatal Intensive Care Unit, Manchester University NHS Foundation Trust, Manchester, Greater Manchester, UK.

J Neonatal Perinatal Med 2021 ;14(2):229-235

Department of Pediatrics, KEM Hospital, Rasta Peth, Pune Maharashtra, India.

Background: Umbilical venous catheters (UVC) and peripherally inserted central catheters (PICC) are commonly used in preterms. UVC is cheap, easy to insert but has shorter dwell time. UVC is replaced after 7 days due to the risk of complications. Read More

J Perinatol 2021 07 2;41(7):1627-1632. Epub 2020 Oct 2.

Department of Radiology, Tripler Army Medical Center, 1 Jarrett White Road, Honolulu, HI, 96859, USA.

Objective: The purpose of the study is to compare conventional linear and fingertip ultrasound transducers, for the evaluation of umbilical catheters, with radiography. Fingertip ultrasound transducers have the potential to simplify sonographic examination due to their small size and ability to fit on a finger.

Study Design: A prospective, IRB approved comparative study was performed. Read More

BMC Med Educ 2020 Sep 21;20(1):318. Epub 2020 Sep 21.

Department of Pediatrics, Faculty of Medicine, University of Tripoli, Tripoli, Libya.

Background: Simulation training is widely used in medical education as students rarely perform clinical procedures, and confidence can influence practitioners' ability to perform procedures. Thus, this study assessed students' perceptions and experiences of a pediatric skills program and compared their informed self-assessment with their preceptor-evaluated performance competency for several pediatric clinical procedures.

Methods: A total of 65 final-year medical students attended a weeklong pediatric skills training course by the University of Tripoli that used a manikin and various clinical scenarios to simulate real-life cases. Read More