794 results match your criteria Catheterization Umbilical Artery


Incidence and risk factors of subclinical umbilical catheter-related thrombosis in neonates.

Thromb Res 2020 May 25;194:21-25. Epub 2020 May 25.

Department of Radiology, Haeundae Paik Hospital, Inje University College of Medicine, Pusan, Republic of Korea.

Introduction: This study aimed to determine the risk factors for subclinical umbilical catheter-related thrombosis (UCRT) and its association with clinical morbidities.

Materials And Methods: In infants without any symptoms associated with umbilical catheterization, the presence of thrombosis was monitored using abdominal ultrasonography within 1 week after umbilical catheter removal. The association between UCRT and the clinical variables was analyzed by comparing the groups with and without UCRT. Read More

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http://dx.doi.org/10.1016/j.thromres.2020.05.034DOI Listing

Neonatal aortic thrombosis: A life threatening complication of umbilical artery catheterisation.

Med J Malaysia 2020 03;75(2):173-174

Universiti Putra Malaysia, Faculty of Medicine and Health Sciences, Department of Paediatric, Serdang, Malaysia.

Umbilical artery catheterisation is considered the standard of care for arterial access in neonatal intensive care unit. It is routinely used for blood sampling and blood pressure monitoring. Unfortunately, an indwelling umbilical catheter have been associated with thrombotic complication which may result in either partial or complete occlusion of the aorta. Read More

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Umbilical artery catheter, aortic dissection, carotid cannulation, and pseudoaneurysm in a neonate: A tale of propagating pathology.

Ann Pediatr Cardiol 2020 Jan-Mar;13(1):87-90. Epub 2019 Jul 19.

Department of Pediatric Intensive Care, Royal Brompton Hospital, London, United Kingdom.

Arterial dissections are uncommon in neonates. Complications include thrombosis, bleeding, dissection, aneurysm and pseudoaneurysm. We report an unusual case of multisite pathology (dissection and pseudoaneurysm) following common vascular interventions. Read More

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http://dx.doi.org/10.4103/apc.APC_67_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6979014PMC

A Novel Epigenetic Drug-Eluting Balloon Angioplasty Device: Evaluation in a Large Animal Model of Neointimal Hyperplasia.

Cardiovasc Drugs Ther 2019 12;33(6):687-692

Eastern Health Clinical School, Monash University, Clayton, Australia.

Purpose: Drug-eluting balloon catheters (DEBc) coated with paclitaxel (PTX) have been associated with potential safety concerns. An efficacious but less toxic balloon coating may reduce these outcomes. We evaluated a novel DEBc, Epi-Solve, coated with metacept-3 (MCT-3), a member of the histone deacetylase inhibitor (HDACi) class of epigenetic agents, in a large animal model of neointimal hyperplasia (NIH). Read More

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http://dx.doi.org/10.1007/s10557-019-06921-wDOI Listing
December 2019

Hepatocyte Transplantation to the Liver via the Splenic Artery in a Juvenile Large Animal Model.

Cell Transplant 2019 Dec 17;28(1_suppl):14S-24S. Epub 2019 Dec 17.

Department of Surgery, Campus Charité Mitte | Campus Virchow-Klinikum, Experimental Surgery, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.

Hepatocyte transplantation (HcTx) is a promising approach for the treatment of metabolic diseases in newborns and children. The most common application route is the portal vein, which is difficult to access in the newborn. Transfemoral access to the splenic artery for HcTx has been evaluated in adults, with trials suggesting hepatocyte translocation from the spleen to the liver with a reduced risk for thromboembolic complications. Read More

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http://dx.doi.org/10.1177/0963689719885091DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7016464PMC
December 2019

Abdominal aortic perforation by an umbilical arterial catheter.

Arch Dis Child Fetal Neonatal Ed 2020 Jan 29;105(1):40. Epub 2019 Aug 29.

Neonatology, Rambam Health Care Campus, Haifa, Israel.

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http://dx.doi.org/10.1136/archdischild-2019-317869DOI Listing
January 2020
5 Reads

Umbilical catheters as vectors for generalized bacterial infection in premature infants regardless of antibiotic use.

J Med Microbiol 2019 Sep 5;68(9):1306-1313. Epub 2019 Jul 5.

Neonatal Intensive Care Unit, Department of Pediatrics, Jagiellonian University Medical College, Kraków, Poland.

Umbilical catheterization offers unique vascular access that is only possible in the neonatal setting due to unobstructed umbilical vessels from foetal circulation. With the cut of the umbilical cord, two arteries and a vein are dissected, allowing quick and painless catheterization of the neonate. Unfortunately, keeping the umbilical access sterile is challenging due to its mobility and necrosis of the umbilical stump, which makes it a perfect model for vessel catheter colonization analysis. Read More

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http://dx.doi.org/10.1099/jmm.0.001034DOI Listing
September 2019
2 Reads

Burden of hypoxia and intraventricular haemorrhage in extremely preterm infants.

Arch Dis Child Fetal Neonatal Ed 2020 May 29;105(3):242-247. Epub 2019 Jun 29.

Neonatal Unit, Rosie Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.

Objective: Thresholds of cerebral hypoxia through monitoring of near-infrared spectroscopy tissue oxygenation index (TOI) were used to investigate the relationship between intraventricular haemorrhage (IVH) and indices of hypoxia.

Design: Prospective observational study.

Setting: A single-centre neonatal intensive care unit. Read More

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http://dx.doi.org/10.1136/archdischild-2019-316883DOI Listing
May 2020
3 Reads

Technical feasibility of umbilical cannulation in midgestation lambs supported by the EXTra-uterine Environment for Neonatal Development (EXTEND).

Artif Organs 2019 Dec 28;43(12):1154-1161. Epub 2019 Jul 28.

Center for Fetal Research, Department of Surgery, Children's Hospital of Philadelphia Research Institute, Philadelphia, Pennsylvania.

EXTEND (EXTra-uterine Environment for Neonatal Development) is a novel system for supporting extremely premature infants that replicates in utero conditions by maintaining a sterile fluid environment and providing gas exchange via a pumpless arteriovenous oxygenator circuit connected to the umbilical vessels. Target gestational age (GA) for EXTEND support in human infants is 23-27 weeks, when immature lungs are most susceptible to injury in the setting of air ventilation. We previously demonstrated physiologic support of premature lambs cannulated at 105-117 days GA (lungs developmentally analogous to the 23-27 week GA human infant) for up to 28 days on EXTEND. Read More

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http://dx.doi.org/10.1111/aor.13524DOI Listing
December 2019
2 Reads

Relation of shunt index with the patent ductus arteriosus among preterm infants under 30 weeks or 1500 g.

J Matern Fetal Neonatal Med 2019 Mar 25:1-6. Epub 2019 Mar 25.

c Department of Pediatrics, Division of Pediatric Cardiology, Faculty of Medicine , Atatürk University , Erzurum , Turkey.

Objective: Patent ductus arteriosus is an important problem in preterms. We aimed to investigate the relation of patent ductus arteriosus with shunt index.

Methods: The preterm infants with a birth weight of ≤1500 g and/or gestational age of <30 weeks and an indication for umbilical artery and venous catheterization formed the study group. Read More

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http://dx.doi.org/10.1080/14767058.2019.1594191DOI Listing
March 2019
15 Reads

Balloon atrial septostomy at the bedside versus the catheterisation laboratory.

Cardiol Young 2019 Mar 28;29(3):454. Epub 2019 Jan 28.

Department of Cardiology,Sree Chitra Tirunal Institute for Medical Sciences and Technology,Thiruvananthapuram,Kerala,India.

A shorter umbilical venous approach provides an opportunity for balloon atrial septostomy in the younger neonate as opposed to those who present at the end of first week of life. However, the ideal choice of access for a bedside balloon atrial septostomy is not well established. Wouldn't prostaglandin infusion be a safer option for transport of babies with dextro-transposition in the neonatal period, when the arterial duct can be kept open? A prenatal diagnosis of dextro-transposition facilitates monitoring and planning of septostomy in the early neonatal period explaining why babies underwent bedside procedures more often. Read More

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http://dx.doi.org/10.1017/S1047951118002214DOI Listing
March 2019
5 Reads

Difficult Vascular Access in Urgent Coronary Artery Angiogram: A Rare Case of a Persistent Sciatic Artery.

JACC Cardiovasc Interv 2018 09 15;11(17):e141-e142. Epub 2018 Aug 15.

Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands.

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http://dx.doi.org/10.1016/j.jcin.2018.06.017DOI Listing
September 2018
2 Reads

Antenatal exposure to nonsteroidal anti-inflammatory drugs and risk of neonatal hypertension.

J Clin Hypertens (Greenwich) 2018 09 27;20(9):1334-1341. Epub 2018 Jul 27.

Perinatal Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.

Nonsteroidal anti-inflammatory drugs (NSAIDs) are used as tocolytics, which are medications that suppress uterine contractions for preterm birth prevention. Their effect on cerebral/systemic vascular beds poses the question of whether antenatal NSAID exposure is associated with neonatal hypertension. We performed a retrospective case-control study in a tertiary neonatal intensive care unit, including 40 hypertension cases (hospitalized neonates ≥ 35 weeks with systolic BP > 100 mm Hg on three consecutive days) compared to 134 controls matched by gestational age at delivery, plurality, and delivery date. Read More

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http://dx.doi.org/10.1111/jch.13354DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6135701PMC
September 2018
52 Reads

Catheter-Related Arterial Thrombosis in Neonates and Children: A Systematic Review.

Thromb Haemost 2018 06 25;118(6):1058-1066. Epub 2018 Apr 25.

Division of Hematology, University Children's Hospital, Zurich, Switzerland.

Catheter-related arterial thrombosis (CAT) is increasingly recognized in children. Available data are scarce and based on expert opinions. This systematic review aimed to identify knowledge on paediatric CAT. Read More

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http://dx.doi.org/10.1055/s-0038-1642635DOI Listing
June 2018
4 Reads

Failed umbilical artery catheterization and adverse outcomes in extremely low birth weight infants.

J Matern Fetal Neonatal Med 2019 Nov 2;32(21):3566-3570. Epub 2018 May 2.

a Division of Neonatal and Developmental Medicine, Department of Pediatrics , Stanford University School of Medicine , Palo Alto , CA , USA.

To determine whether successful catheterization of the umbilical artery is associated with a reduced risk of death or neurodevelopment impairment among critically ill extremely low birth weight (ELBW) infants. A retrospective chart review was conducted between 2007 and 2014 at Stanford University for all ELBW infants that required intubation immediately after birth. The primary outcome was death or neurodevelopmental impairment at 18-22 months. Read More

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http://dx.doi.org/10.1080/14767058.2018.1468430DOI Listing
November 2019
8 Reads

Noncanonical Matrix Metalloprotease 1-Protease-Activated Receptor 1 Signaling Drives Progression of Atherosclerosis.

Arterioscler Thromb Vasc Biol 2018 06 5;38(6):1368-1380. Epub 2018 Apr 5.

From the Center for Hemostasis and Thrombosis Research, Tufts Medical Center, Tufts University School of Medicine, Boston, MA (R.R., T.H., G.K., E.K.F., S.E.T., A.S., L.C., A.K.)

Objective: Protease-activated receptor-1 (PAR1) is classically activated by thrombin and is critical in controlling the balance of hemostasis and thrombosis. More recently, it has been shown that noncanonical activation of PAR1 by matrix metalloprotease-1 (MMP1) contributes to arterial thrombosis. However, the role of PAR1 in long-term development of atherosclerosis is unknown, regardless of the protease agonist. Read More

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http://dx.doi.org/10.1161/ATVBAHA.118.310967DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6076425PMC
June 2018
23 Reads

Postnatal dilatation of umbilical cord vessels and its impact on wall integrity: Prerequisite for the artificial placenta.

Int J Artif Organs 2018 Jul 22;41(7):393-399. Epub 2018 Mar 22.

1 Division of Neonatology, Department of Pediatrics, McMaster University, Hamilton, ON, Canada.

Introduction: A lung assist device, which acts as an artificial placenta, can provide additional gas exchange for preterm and term newborns with respiratory failure. The concept of the lung assist device requires a large bore access via umbilical vessels to allow pumpless extracorporeal blood flow rates up to 30 mL/kg/min. After birth, constricted umbilical vessels need to be reopened for vascular access. Read More

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http://dx.doi.org/10.1177/0391398818763663DOI Listing
July 2018
13 Reads

Role of ultrasound for central catheter tip localization in neonates: a review of the current evidence.

J Matern Fetal Neonatal Med 2019 Jul 15;32(14):2429-2437. Epub 2018 Feb 15.

b Department of Pulmonology , Mofid Children's Hospital, Shahid Beheshti University of Medical Sciences , Tehran , Iran.

Central catheters are known as "life lines" in intensive care units and are used frequently in neonatal intensive care unit (NICU) for multiple indications. The central catheters used in NICU includes umbilical venous catheter (UVC), umbilical arterial catheter (UAC) and peripherally inserted central catheter (PICC) lines. The tip of these central lines needs to be in a correct position as malpositioned central line tips lead to many neonatal complications. Read More

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http://dx.doi.org/10.1080/14767058.2018.1437135DOI Listing
July 2019
16 Reads

Umbilical cannulation optimizes circuit flows in premature lambs supported by the EXTra-uterine Environment for Neonatal Development (EXTEND).

J Physiol 2018 05 2;596(9):1575-1585. Epub 2018 Mar 2.

Center for Fetal Research, Department of Surgery.

Key Points: Bronchopulmonary dysplasia is a disease of extreme prematurity that occurs when the immature lung is exposed to gas ventilation. We designed a novel 'artificial womb' system for supporting extreme premature lambs (called EXTEND) that obviates gas ventilation by providing oxygen via a pumpless arteriovenous circuit with the lamb submerged in sterile artificial amniotic fluid. In the present study, we compare different arteriovenous cannulation strategies on EXTEND, including carotid artery/jugular vein (CA/JV), carotid artery/umbilical vein (CA/UV) and umbilical artery/umbilical vein (UA/UV). Read More

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http://dx.doi.org/10.1113/JP275367DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5924826PMC
May 2018
21 Reads

Repair of a mycotic abdominal aortic aneurysm in a neonate using an everted jugular vein patch.

J Vasc Surg Cases Innov Tech 2017 Dec 2;3(4):218-220. Epub 2017 Nov 2.

Section of Pediatric Surgery, Department of Surgery, Yale University School of Medicine, New Haven, Conn.

A 43-day-old boy presented with bacteremia after umbilical artery catheterization. Duplex ultrasound examination revealed a 1.1- × 1. Read More

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http://dx.doi.org/10.1016/j.jvscit.2017.08.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5765176PMC
December 2017
10 Reads

Umbilical artery perforation: a potentially life-threatening complication of umbilical artery catheterisation.

BMJ Case Rep 2017 Nov 14;2017. Epub 2017 Nov 14.

Department of Neonatology, VU University Medical Center, Amsterdam, The Netherlands.

Umbilical artery catheterisation is frequently performed in preterm or critically ill newborn infants for invasive monitoring of blood pressure and blood sampling for laboratory tests. It is associated with well-known complications like catheter-related infections, thromboembolic events and aneurysmal formation of the aorta. In this report, we present another major complication of umbilical artery catheterisation: umbilical artery perforation. Read More

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http://dx.doi.org/10.1136/bcr-2017-222664DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5695430PMC
November 2017
9 Reads

Association between Umbilical Catheters and Neonatal Outcomes in Extremely Preterm Infants.

Am J Perinatol 2018 Feb 14;35(3):233-241. Epub 2017 Sep 14.

Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada.

Objective:  The objective of this study was to examine the association between umbilical catheters and a composite outcome of mortality or major neonatal morbidity in extremely preterm infants.

Study Design:  Data were abstracted from the Canadian Neonatal Network database for infants born at <29 weeks' gestational age and admitted to 29 neonatal intensive care units between January 2010 and December 2012. Four groups were identified: those with no umbilical catheters, umbilical venous catheters (UVCs), umbilical artery catheters (UACs), and those with both UVCs and UACs. Read More

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http://dx.doi.org/10.1055/s-0037-1606607DOI Listing
February 2018
31 Reads
1.597 Impact Factor

Accuracy of 11 formulae to guide umbilical arterial catheter tip placement in newborn infants.

Arch Dis Child Fetal Neonatal Ed 2018 Jul 17;103(4):F364-F369. Epub 2017 Aug 17.

Newborn Research, The Royal Women's Hospital, Melbourne, Australia.

Background: Umbilical arterial catheter (UAC) insertion is a common procedure in the neonatal intensive care unit (NICU). Correct placement of the tip of the UAC at first attempt minimises handling of the infant and reduces the risk of infection and complications. We aimed to determine the accuracy of 11 published formulae to guide UAC placement. Read More

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http://dx.doi.org/10.1136/archdischild-2017-313039DOI Listing
July 2018
24 Reads

Vessel Perforation and False Tracking Resulting From Umbilical Artery Catheterization: A Case Report and Literature Review.

Pediatr Dev Pathol 2017 Sep-Oct;20(5):426-431. Epub 2017 Jan 26.

1 Department of Pediatrics, Rutgers Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA.

We report an extremely low-birth-weight neonate who developed umbilical artery perforation and false tracking. There was no life-threatening event relating to the complication. Diagnosis was made at postmortem examination. Read More

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http://dx.doi.org/10.1177/1093526616686454DOI Listing
May 2019
16 Reads
0.860 Impact Factor

A Newborn with an Alternative Porto-Caval Shunt.

Pol J Radiol 2017 16;82:320-321. Epub 2017 Jun 16.

Department of Radiology, Gazi University, Faculty of Medicine, Ankara, Turkey.

Background: Absent ductus venosus (ADV) is a rare condition, but it should be known that this embryonic anomaly may be detected by fetal echocardiographic or newborn ultrasound examinations.

Case Report: We present a baby with an ADV and an accompanying alternative porto-caval shunt between the right portal vein and inferior vena cava detected on postnatal ultrasound examination.

Conclusions: Variations in the fetal umbilical or porto-systemic circulations should be detected by fetal or newborn ultrasound examinations and kept in mind before common interventions such as UV catheterizations. Read More

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http://www.polradiol.com/abstract/index/idArt/900726
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http://dx.doi.org/10.12659/PJR.900726DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5484609PMC
June 2017
20 Reads

Non-surgical Management of a Mycotic Internal Iliac Artery Aneurysm in a Neonate: Case Report and Review of the Literature.

Cardiovasc Intervent Radiol 2017 Jul 14;40(7):1112-1114. Epub 2017 Feb 14.

Department of Plastic Surgery, Leeds General Infirmary, Great George Street, Leeds, LS1 3EX, UK.

We report a unique case of neonatal mycotic internal iliac artery aneurysm managed non-operatively. The child had multifocal osteomyelitis and no history of umbilical artery catheterisation. The aneurysm was regularly scanned and monitored until its obliteration by thrombus 17 days after initial detection. Read More

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http://dx.doi.org/10.1007/s00270-017-1595-3DOI Listing
July 2017
8 Reads

Surgical treatment of abdominal aortic aneurysms in infancy and early childhood.

J Vasc Surg 2016 Nov 18;64(5):1252-1261. Epub 2016 Jul 18.

Section of Vascular Surgery, Department of Surgery, University of Michigan, Ann Arbor, Mich.

Objective: Pediatric abdominal aortic aneurysms (AAAs) are rare. The intent of this report was to review the presentation and surgical management of AAAs in infancy and early childhood.

Methods: The clinical courses of young children undergoing AAA surgery were subjected to a retrospective review and analysis. Read More

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http://dx.doi.org/10.1016/j.jvs.2016.04.021DOI Listing
November 2016
9 Reads

Delayed Diagnosis of Iatrogenic Bladder Perforation in a Neonate.

Case Rep Urol 2016 26;2016:1425373. Epub 2016 Sep 26.

College of Medicine, University of Central Florida, 6850 Lake Nona Blvd, Orlando, FL 32827, USA; Pediatric Urology, Arnold Palmer Children's Hospital, 92 W. Miller St, Orlando, FL 32806, USA.

Iatrogenic bladder injuries have been reported in the neonate during umbilical artery/vein catheterization, voiding cystourethrogram, urinary catheterizations, and overwhelming hypoxic conditions. Patients with iatrogenic bladder perforations can present with acute abdomen indicating urinary peritonitis, septic-uremic shock, or subtle symptoms like abdominal distension, pain, hematuria, uremia, electrolyte imbalances, and/or difficulty urinating. The following neonatal case report of perforated bladder includes a review of the signs, symptoms, diagnostic tools, and management of bladder injury in neonates. Read More

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http://dx.doi.org/10.1155/2016/1425373DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5056302PMC
September 2016
7 Reads

Endothelial repair in stented arteries is accelerated by inhibition of Rho-associated protein kinase.

Cardiovasc Res 2016 12 26;112(3):689-701. Epub 2016 Sep 26.

Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield S10 2RX, UK

Aims: Stent deployment causes endothelial cells (EC) denudation, which promotes in-stent restenosis and thrombosis. Thus endothelial regrowth in stented arteries is an important therapeutic goal. Stent struts modify local hemodynamics, however the effects of flow perturbation on EC injury and repair are incompletely understood. Read More

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http://dx.doi.org/10.1093/cvr/cvw210DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5157135PMC
December 2016
87 Reads

[Balloon valvuloplasty for aortic stenosis using umbilical vein access in a newborn: First experience in Turkey].

Turk Kardiyol Dern Ars 2016 Sep;44(6):521-3

Department of Pediatric Cardiology, İstanbul University, İstanbul Faculty of Medicine, İstanbul, Turkey.

Balloon valvuloplasty is an effective therapy for severe congenital aortic valve stenosis, with mild aortic insufficiency and minimal intermediate-term restenosis. No consensus currently exists regarding optimal vascular approach for balloon dilatation in newborns with critical or severe aortic valve stenosis. Critical aortic valve stenosis in newborns must be treated promptly and effectively. Read More

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http://dx.doi.org/10.5543/tkda.2016.39969DOI Listing
September 2016
8 Reads

The effect of intraumbilical fetal nutrition via a subcutaneously implanted port system on amino acid concentration by severe IUGR human fetuses.

J Perinat Med 2017 Feb;45(2):227-236

Objective: To determine if intrauterine intraumbilical supplementation with amino acids (AA) and glucose can improve neonatal outcome of severe growth restricted human fetuses (IUGR).

Methods: Prospective pilot study of intrauterine treatment of severe IUGR fetuses [n=14, 27 weeks of gestation (range 23-31)] with cerebroplacental ratio <1, with long-term intraumbilical AA and glucose supplementation (10% of feto-placental blood volume/day) using a perinatal port system alone (n=5) or combined with hyperbaric oxygenation (n=1, HBO) vs. control group (n=8). Read More

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http://dx.doi.org/10.1515/jpm-2016-0155DOI Listing
February 2017
10 Reads

Scrotal hypoperfusion: a rare complication of umbilical artery catheterisation.

Arch Dis Child Fetal Neonatal Ed 2016 Nov 7;101(6):F561. Epub 2016 Jul 7.

Department of Neonatology, Corniche Hospital, Abu Dhabi, UAE.

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http://dx.doi.org/10.1136/archdischild-2015-309298DOI Listing
November 2016
5 Reads

TW-01, a piperazinedione-derived compound, inhibits Ras-mediated cell proliferation and angioplasty-induced vascular restenosis.

Toxicol Appl Pharmacol 2016 08 14;305:194-202. Epub 2016 Jun 14.

The Ph.D. Program for Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei 11031, Taiwan; Department of Pharmacology, College of Medicine, Taipei Medical University, Taipei 10031, Taiwan. Electronic address:

Purpose: Vascular smooth muscle cell (VSMC) proliferation plays a critical role in the pathogenesis of atherosclerosis and restenosis. This study investigated piperazinedione derived compound TW-01-mediated inhibitory effects on VSMC proliferation and intimal hyperplasia.

Methods: Cell proliferation was determined using [(3)H]-thymidine incorporation and MTT assay; cell cycle distribution was measured using flow cytometry; proteins and mRNA expression were determined using western blotting and RT-PCR analyses; DNA binding activity of nuclear factor-κB (NF-κB), as measured using enzyme-linked immunosorbent assays (ELISA); in vivo effects of TW-01 were determined using balloon angioplasty in the rat. Read More

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http://dx.doi.org/10.1016/j.taap.2016.06.013DOI Listing
August 2016
12 Reads

Activation of Peroxisome Proliferator-Activated Receptor-δ as Novel Therapeutic Strategy to Prevent In-Stent Restenosis and Stent Thrombosis.

Arterioscler Thromb Vasc Biol 2016 08 9;36(8):1534-48. Epub 2016 Jun 9.

From the Department of Molecular Medicine, A.I. Virtanen Institute, University of Eastern Finland, Kuopio, Finland (J.H., S.Y.-H.); Centre for R&D, Uppsala University/County Council of Gaevleborg, Gaevle, Sweden (O.L.); Institute for Pathology, University Clinic of Schleswig-Holstein, Campus Kiel, Kiel, Germany (J.H.B.); Max-Delbrück Center for Molecular Medicine, Berlin, Germany (W.-H.S., D.M., A.H., J.-D.D., L.T., F.B.); Department of Cardiology (B.P., F.B.) and Center for Cardiovascular Research/CCR, Institute of Laboratory Medicine Clinical Chemistry and Pathobiochemistry (K.K.), Charité-Universitaetsmedizin Berlin, Berlin, Germany; Institute of Biomaterial Science and Berlin-Brandenburg Centre for Regenerative Therapies (BCRT), Helmholtz-Zentrum Geesthacht, Teltow, Germany (F.J., C.M.); Institute for Diabetes and Obesity, Helmholtz Zentrum Muenchen, Munich, German Research Center for Environmental Health, Germany (M.J.); and Cologne Interventional Immunology, University Hospital of Cologne, Cologne, Germany (M.v.B.-B.).

Objective: Drug-eluting coronary stents reduce restenosis rate and late lumen loss compared with bare-metal stents; however, drug-eluting coronary stents may delay vascular healing and increase late stent thrombosis. The peroxisome proliferator-activated receptor-delta (PPARδ) exhibits actions that could favorably influence outcomes after drug-eluting coronary stents placement.

Approach And Results: Here, we report that PPARδ ligand-coated stents strongly reduce the development of neointima and luminal narrowing in a rabbit model of experimental atherosclerosis. Read More

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https://www.ahajournals.org/doi/10.1161/ATVBAHA.115.306962
Publisher Site
http://dx.doi.org/10.1161/ATVBAHA.115.306962DOI Listing
August 2016
62 Reads

Risk factors and outcomes of carbapenem-resistant Acinetobacter baumannii ventilator-associated pneumonia in the neonate: A case-case-control study.

J Infect Chemother 2016 Jul 24;22(7):444-9. Epub 2016 May 24.

Department of Radiology, Faculty of Medicine, Prince of Songkla University, Songkhla, Thailand.

Background: Carbapenem-resistant and susceptible Acinetobacter baumannii (CRAB and CSAB) have emerged as serious threats among critically ill neonates. We aimed to identify the risks and outcomes for CRAB and CSAB ventilator-associated pneumonia (VAP) compared with a control group.

Methods: We performed a retrospective and case-case-control study in a neonatal intensive care unit between 2009 and 2014. Read More

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http://dx.doi.org/10.1016/j.jiac.2016.03.013DOI Listing
July 2016
11 Reads
1.384 Impact Factor

Evaluation of Multiple Biological Therapies for Ischemic Cardiac Disease.

Cell Transplant 2016 10;25(9):1591-1607. Epub 2016 May 10.

University of Utah School of Medicine, Salt Lake City, UT, USA.

The development of cell- and gene-based strategies for regenerative medicine offers a therapeutic option for the repair and potential regeneration of damaged cardiac tissue post-myocardial infarction (MI). Human umbilical cord subepithelial cell-derived stem cells (hUC-SECs), human bone marrow-derived mesenchymal stem cells (hBM-MSCs), and human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs), all derived from human tissue, have been shown to have in vitro and in vivo therapeutic potential. Additionally, S100a1, VEGF165, and stromal-derived factor-1α (SDF-1α) genes all have the potential to improve cardiac function and/or effect adverse remodeling. Read More

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http://journals.sagepub.com/doi/full/10.3727/096368916X69150
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http://dx.doi.org/10.3727/096368916X691501DOI Listing
November 2017
35 Reads

Abdominal Aortic Thrombosis in a Healthy Neonate.

Ann Vasc Surg 2016 Apr 21;32:131.e7-9. Epub 2016 Jan 21.

Department of Surgery, Clinical Hospital Center Zagreb, Zagreb, Croatia.

Abdominal aortic thrombosis is a rare entity in neonates and has mostly been associated with umbilical artery or cardiac catheterization. We present a complicated case of an otherwise healthy neonate who developed thrombosis of abdominal aorta with renal failure. Therapy with intravenous heparin was unsuccessful, and thrombolysis was contraindicated because of disseminated intravascular coagulation so we decided to perform open thrombectomy using the left retroperitoneal approach. Read More

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http://dx.doi.org/10.1016/j.avsg.2015.10.014DOI Listing
April 2016
38 Reads
1.030 Impact Factor

Comparison of non-invasive vs invasive blood pressure measurement in neonates undergoing therapeutic hypothermia for hypoxic ischemic encephalopathy.

J Perinatol 2016 05 7;36(5):381-5. Epub 2016 Jan 7.

Division of Neonatology, Hospital for Sick Children, Toronto, ON, Canada.

Objective: To evaluate the accuracy of blood pressure (BP) measured non-invasively (NIBP) compared with invasive arterial BP (IABP) measured by umbilical arterial catheter in neonates undergoing therapeutic hypothermia (TH) for hypoxic ischemic encephalopathy (HIE).

Study Design: We conducted a retrospective study of neonates with gestational age (GA)⩾35 weeks with HIE who received TH. Paired NIBP and IABP measurements were obtained during TH and during normothermia. Read More

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http://dx.doi.org/10.1038/jp.2015.198DOI Listing
May 2016
1 Read

Topical nitroglycerin ointment to aid umbilical artery cannulation in neonates.

Resuscitation 2016 Feb 29;99:e5-6. Epub 2015 Dec 29.

Newborn Research Centre, Royal Women's Hospital, Melbourne, Australia; Murdoch Childrens Research Institute, Melbourne, Australia; The University of Melbourne, Melbourne, Australia; PIPER, Neonatal Transport, The Royal Children's Hospital, Melbourne, Australia.

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http://dx.doi.org/10.1016/j.resuscitation.2015.11.030DOI Listing
February 2016
123 Reads

Curcumin accelerates reendothelialization and ameliorates intimal hyperplasia in balloon-injured rat carotid artery via the upregulation of endothelial cell autophagy.

Int J Mol Med 2015 Dec 9;36(6):1563-71. Epub 2015 Oct 9.

Department of Neurosurgery and Brain and Nerve Research Laboratory, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215006, P.R. China.

Delayed reendothelialization and intimal hyper-plasia (IH) contribute to the failure of vascular interventions. Curcumin (Cur) has been used for various types of diseases with antioxidant, antiproliferative and anti‑inflammatory effects. However, investigations involving the application of Cur in inhibiting IH are limited. Read More

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http://dx.doi.org/10.3892/ijmm.2015.2365DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4678154PMC
December 2015
33 Reads

Transumbilical arterial embolization of a large dural arteriovenous fistula in a low-birth-weight neonate with congestive heart failure.

Childs Nerv Syst 2016 Apr 8;32(4):723-6. Epub 2015 Sep 8.

Department of Neuro-Intervention, Osaka City General Hospital, 2-13-22, Miyakojima-Hondori, Miyakojima, Osaka, 534-0021, Japan.

Purpose: The purpose of this study was to report transumbilical arterial embolization of a large dural arteriovenous fistula (AVF) in a low-birth-weight neonate with congestive heart failure (CHF).

Case Presentation: A female neonate was delivered by cesarean section at 31 weeks of gestation. Her birth weight was 1538 g and Apgar scores were 6 at both 1 and 5 min. Read More

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http://dx.doi.org/10.1007/s00381-015-2906-0DOI Listing
April 2016
33 Reads

Rupture and displacement of umbilical arterial catheter: Bilateral arterial occlusion in a very low birth weight preterm.

Arch Argent Pediatr 2015 Oct;113(5):e283-5

Departamento de Neonatología, Facultad de Medicina, Universidad Kirikkale.

Umbilical vessel catheterization is a common procedure in Neonatal Intensive Care Units, especially in very low birthweight infants. Rarely, umbilical artery catheters break, and the retained fragments can cause thrombosis, infection, distal embolization, and even death. Herein, we describe a neonate with clinically significant bilateral limb ischemia developing after removal of a broken umbilical artery catheter. Read More

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http://dx.doi.org/10.5546/aap.2015.e283DOI Listing
October 2015
47 Reads

Renal vascular thrombosis in the newborn.

Pediatr Nephrol 2016 Jun 15;31(6):907-15. Epub 2015 Jul 15.

Shaw-NKF-NUH Children's Kidney Center, KTP-National University Children's Medical Institute, National University Health System, Singapore, Singapore.

Neonatal renal vascular thrombosis is rare but has devastating sequelae. The renal vein is more commonly affected than the renal artery. Most neonates with renal vein thrombosis present with at least one of the three cardinal signs, namely, abdominal mass, macroscopic hematuria and thrombocytopenia, while unilateral renal artery thrombosis presents with transient hypertension. Read More

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http://dx.doi.org/10.1007/s00467-015-3160-0DOI Listing
June 2016
60 Reads

Transumbilical retrieval of broken umbilical artery catheter in a 1000 gm premature newborn.

J Vasc Access 2015 Sep 29;16(5):e93-4. Epub 2015 Sep 29.

Dr. Sami Ulus Maternity and Children Research and Training Hospital, Ankara - Turkey.

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http://dx.doi.org/10.5301/jva.5000445DOI Listing
September 2015
6 Reads

A novel technique for simultaneous whole-body and multi-organ decellularization: umbilical artery catheterization as a perfusion-based method in a sheep foetus model.

Int J Exp Pathol 2015 Apr;96(2):116-32

Pediatric Urology Research Center, Section of Tissue Engineering and Stem Cells Therapy, Children's Hospital Medical Center, Tehran University of Medical Sciences, Tehran, Iran (IRI).

The aim of this study was to develop a method to generate multi-organ acellular matrices. Using a foetal sheep model have developed a method of systemic pulsatile perfusion via the umbilical artery which allows for simultaneous multi-organ decellularization. Twenty sheep foetuses were systemically perfused with Triton X-100 and sodium dodecyl sulphate. Read More

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http://dx.doi.org/10.1111/iep.12124DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4459805PMC
April 2015
61 Reads
2.170 Impact Factor

Fully automated simultaneous umbilical arteriovenous exchange transfusion in term and late preterm infants with neonatal hyperbilirubinemia.

J Matern Fetal Neonatal Med 2016 1;29(8):1274-8. Epub 2015 Jun 1.

a Faculty of Medicine , Selcuk University , Neonatology, Konya , Turkey.

Objectives: The purpose of this study was to compare the efficacy and safety of two different catheterization techniques of exchange transfusion (ET) used in the therapy of newborn jaundice: fully automated two-way ET technique and the classical one-way ET.

Patients And Methods: The study included babies at gestational age of >34 weeks. In total, 107 ETs were performed on 86 babies. Read More

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http://dx.doi.org/10.3109/14767058.2015.1045864DOI Listing
October 2016
14 Reads

Simple measurements to place umbilical catheters using surface anatomy.

J Perinatol 2015 Jul 22;35(7):476-80. Epub 2015 Jan 22.

MedStar Georgetown University Hospital, Washington, DC, USA.

Objective: To use external anatomical landmarks to determine a new method for the estimation of appropriate insertion length of umbilical catheters, suitable for newborn infants of varying birth weight (BW) and gestational age.

Study Design: Neonates who had umbilical venous (UVC) or arterial (UAC) catheters placed soon after birth were included in the study. Catheters were placed using formulas derived by Shukla (1986) and/or Wright (2007), and adjusted to appropriate positions confirmed radiologically: UAC tip between T6-T10 vertebral bodies and UVC at the level of the diaphragm±0. Read More

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http://dx.doi.org/10.1038/jp.2014.239DOI Listing
July 2015
40 Reads

New technique for umbilical artery catheter placement in the neonate.

J Pediatr 2015 Feb 18;166(2):501. Epub 2014 Nov 18.

Division of Neonatal and Developmental Medicine, Department of Pediatrics, Stanford University School of Medicine, Palo Alto, California.

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http://dx.doi.org/10.1016/j.jpeds.2014.10.027DOI Listing
February 2015
8 Reads

Comparison of Wright's formula and the Dunn method for measuring the umbilical arterial catheter insertion length.

Pediatr Neonatol 2015 Apr 12;56(2):120-5. Epub 2014 Oct 12.

Department of Pediatrics, Kangwon National University Hospital, Chuncheon, South Korea; Institute of Medical Sciences, Kangwon National University School of Medicine, Chuncheon, South Korea. Electronic address:

Background: Umbilical artery catheterization is the standard procedure for arterial access in neonatal intensive care units. An umbilical arterial catheter (UAC) needs to be placed accurately during the initial insertion because malpositioning increases catheter-related complications and subsequent repositioning exposes newborns to unnecessary handling, further radiologic exposure, and an increased risk of infection. To measure the UAC insertion length in newborns, we compared the conventional practice (i. Read More

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http://dx.doi.org/10.1016/j.pedneo.2014.07.004DOI Listing
April 2015
7 Reads

Using lateral radiographs to determine umbilical venous catheter tip position in neonates.

Ir Med J 2014 Sep;107(8):256-8

We aimed to assess the difference in measurement of the distance of the UVC tip from the diaphragm between (Anteroposterior) AP and lateral radiographs and to determine the reliability of the measurement of UVC tip distance from the diaphragm between the two views. A retrospective review of paired AP and lateral radiographs taken to assess UVC tip position was carried out in 25 infants was conducted and reliability analysis was carried out. There was a significant difference in the mean (SD) distance of the UVC catheter above the diaphragm between the AP and lateral radiographs: 8. Read More

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September 2014
6 Reads