232 results match your criteria Case reports in transplantation[Journal]


Proton Pump Inhibitor-Induced Galactorrhea in a Kidney Transplant Recipient: A Friend or Foe?

Case Rep Transplant 2020 13;2020:8108730. Epub 2020 May 13.

Department of Medicine, Division of Nephrology and Transplantation, University of Vermont Medical Center, Burlington, Vermont, USA.

Over the last decades, proton pump inhibitors (PPIs) have been widely used as the mainstay for treatment and prevention of gastrointestinal side effects, gastroesophageal reflux, and peptic ulcer disease. However, their safety profile has come into question recently after reports relating them to several side effects as well as kidney disease. Omeprazole, one of the mainly used PPIs, is almost entirely metabolized by the liver but the resulting metabolites are renally excreted. Read More

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http://dx.doi.org/10.1155/2020/8108730DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7254079PMC

Salvage after Retroperitoneal Kidney Allograft Torsion.

Case Rep Transplant 2020 14;2020:8024598. Epub 2020 Jan 14.

Division of Transplantation, Department of Surgery, Yale University School of Medicine, New Haven, CT, USA.

Torsion of a transplanted kidney into the retroperitoneal space is a rare occurrence, with only three other reported cases. Failure after kidney transplantation is caused by surgical, immunological, and infective complications. Torsion is a complication that poses a serious risk of ischemic graft failure, and, if suspected, sonographic evaluation helps ascertain the diagnosis. Read More

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http://dx.doi.org/10.1155/2020/8024598DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7201506PMC
January 2020

Subcapsular Renal Hematoma in Simultaneous Pancreas Kidney Transplantation.

Case Rep Transplant 2020 11;2020:6152035. Epub 2020 May 11.

Department of Clinical and Experimental Medicine, Division of Metabolism and Cell Transplantation, University of Pisa, Pisa, Italy.

Subcapsular renal hematoma (SRH) is a challenging condition, which may jeopardize kidney function or constitute a life-threatening event. This is particularly true in single-kidney patients, such as kidney-transplant recipients. SRH may exert an excessive pressure on the surrounding parenchyma, thus resulting in hypoperfusion and ischemia, with high risk of acute kidney failure and graft loss. Read More

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http://dx.doi.org/10.1155/2020/6152035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7238346PMC

Transfusion-Dependent Anemia in a Simultaneous Pancreas and Kidney Transplant Recipient.

Case Rep Transplant 2020 8;2020:2841456. Epub 2020 Apr 8.

Imperial College Renal and Transplant Centre, Imperial College Healthcare NHS Trust, Hammersmith Hospital, London, UK.

A case of transfusion-dependent anemia in a simultaneous pancreas and kidney (SPK) transplant recipient that masqueraded as gastrointestinal bleeding (GIB) is described. The anemia was attributed to bleeding from the donor duodenal cuff based on balloon enteroscopy findings. The patient underwent multiple contrast-enhanced computed tomography scans and multiple endoscopies with confounding features until, eventually, the diagnosis was established. Read More

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http://dx.doi.org/10.1155/2020/2841456DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7168697PMC

Cutaneous Vasculitis and Central Nervous System Infarctions due to Varicella Zoster Virus Vasculopathy in an Immunocompromised Patient.

Case Rep Transplant 2020 6;2020:5049627. Epub 2020 Apr 6.

Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA.

Varicella zoster virus (VZV) infection commonly presents as varicella during childhood, and zoster, later in life. Here, we present a rare and interesting case of VZV infection that manifested with both cerebral and spinal infarctions and cutaneous vasculitis in the absence of a classic vesicular rash in an immunocompromised patient. Read More

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http://dx.doi.org/10.1155/2020/5049627DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7165345PMC

Wound Infection with an Unusual Pathogen after Liver Transplantation.

Case Rep Transplant 2020 2;2020:8396507. Epub 2020 Apr 2.

Liver Transplantation Research Center, Department of Infectious Diseases, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran.

Mucormycosis is a rare and highly invasive fungal infection caused by Mucorales fungi of the class Zygomycetes. Cutaneous mucormycosis typically has a good survival rate when diagnosed early. In this report, we presented a patient with surgical site mucormycosis after liver transplant surgery. Read More

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http://dx.doi.org/10.1155/2020/8396507DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7154978PMC

Biological Mesh Repair of a Large Incisional Hernia Containing a Kidney Transplant in the Presence of Inflammation.

Case Rep Transplant 2020 24;2020:5675613. Epub 2020 Mar 24.

Department of Nephrology and Renal Transplantation, Guy's Hospital, London, UK.

The incidence of incisional hernia after kidney transplantation varies between 1.1% and 3.8%. Read More

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http://dx.doi.org/10.1155/2020/5675613DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7128063PMC

Lung Transplantation in a Patient with COPA Syndrome.

Case Rep Transplant 2020 31;2020:3624795. Epub 2020 Mar 31.

Mayo Clinic, 4500 San Pablo Rd S, Jacksonville, FL 32224, USA.

COPA syndrome is a newly discovered, rare genetic autoimmune disorder, which can affect the lungs, joints, and kidneys. It is difficult to recognize, and the survival benefit of lung transplantation for these patients is not yet known. We present a case of a 24-year-old woman who received bilateral lung transplant for COPA syndrome. Read More

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http://dx.doi.org/10.1155/2020/3624795DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7152970PMC

The Liver That Cured Christmas: Case Report of Orthotopic Liver Transplant in a Patient with Hemophilia B.

Case Rep Transplant 2020 18;2020:7873803. Epub 2020 Mar 18.

Department of Oncology, Houston Methodist Hospital, USA.

Herein, we discuss a case of a 39-year-old male with hemophilia B, who developed end-stage liver disease secondary to nonalcoholic steatohepatitis, that underwent orthotopic liver transplantation (OLT) as a curative means for his liver disease and coagulation disorder. Existing case reports have demonstrated favorable outcomes in patients outside of the United States who received continuous infusions of recombinant factor IX replacement in the perioperative setting after liver transplant. Given limitations in the stability of the recombinant factor IX products in the United States, a dosing strategy was comprised of once daily bolus dosing to achieve satisfactory factor IX levels. Read More

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http://dx.doi.org/10.1155/2020/7873803DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7104118PMC

Successful A2 to B Deceased Donor Kidney Transplant after Desensitization for High-Strength Non-HLA Antibody Made Possible by Utilizing a Hepatitis C Positive Donor.

Case Rep Transplant 2020 13;2020:3591274. Epub 2020 Mar 13.

Transplant Institute, NYU Langone Health, New York, NY, USA.

Desensitization using plasma exchange can remove harmful antibodies prior to transplantation and mitigate risks for hyperacute and severe early acute antibody-mediated rejection. Traditionally, the use of plasma exchange requires a living donor so that the timing of treatments relative to transplant can be planned. Non-HLA antibody is increasingly recognized as capable of causing antibody-mediated renal allograft rejection and has been associated with decreased graft longevity. Read More

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http://dx.doi.org/10.1155/2020/3591274DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7094197PMC

Late-Onset Posttransplant Lymphoproliferative Disorders after Solid Organ Transplantation in Adults: A Case Series and Review of the Literature.

Case Rep Transplant 2020 10;2020:8247308. Epub 2020 Feb 10.

MD Anderson Cancer Center at Cooper, Camden, NJ, USA.

The posttransplant lymphoproliferative disorders (PTLDs) are a heterogeneous group of neoplasms that have wide variety of clinical and histological presentations. The management of PTLDs is challenging due to variety of involvement sites and histological types. The length and type of immunosuppression are correlated with the emergence of PTLDs, and most of the cases appear within the first two years after transplant. Read More

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http://dx.doi.org/10.1155/2020/8247308DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7035525PMC
February 2020

Parvovirus Infection-Related Anemia after Kidney Transplantation.

Case Rep Transplant 2020 31;2020:6437392. Epub 2020 Jan 31.

Keck School of Medicine of USC, 1975 Zonal Ave., Los Angeles, CA 90033, USA.

Anemia postkidney transplantation is an important issue which has been correlated with increased hospitalizations and higher mortality. Infections, including those due to parvovirus B19, CMV, and BK virus (polyomavirus), have also been associated with an increased risk of anemia. Here, we present a case of new-onset anemia in a kidney transplant recipient within 3 months of transplant. Read More

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http://dx.doi.org/10.1155/2020/6437392DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7013336PMC
January 2020

Hepatic Artery Pseudoaneurysm in the Liver Transplant Recipient: A Case Series.

Case Rep Transplant 2019 27;2019:9108903. Epub 2019 Dec 27.

Department of Surgery, University of Maryland School of Medicine, Baltimore, MD, USA.

Introduction: Hepatic artery pseudoaneurysm is a rare and potentially fatal complication of liver transplantation with a reported incidence of 0.3-2.6% and associated mortality approaching 75%. Read More

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http://dx.doi.org/10.1155/2019/9108903DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6959152PMC
December 2019

Wide Excision of a Retroperitoneal Liposarcoma with En Bloc Ureterectomy and Renal Salvage by Autotransplantation.

Case Rep Transplant 2019 11;2019:9725169. Epub 2019 Dec 11.

Department of Surgery, University of the Philippines-Philippine General Hospital, Manila, Philippines.

Liposarcoma is a malignant mesenchymal neoplasm composed of adipose tissue with varying degrees of atypia. These tumors grow slowly and may reach an enormous size particularly if located in the retroperitoneum. We report a 40-year-old male with a 6-month history of gradual abdominal enlargement. Read More

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http://dx.doi.org/10.1155/2019/9725169DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6927075PMC
December 2019

Severely Disseminated Kaposi Sarcoma after ABO-Incompatible Kidney Transplantation Treated Successfully with Paclitaxel and Gemcitabine Combined with Hemodialysis.

Case Rep Transplant 2019 11;2019:8105649. Epub 2019 Dec 11.

Department of Oncology, Herlev Hospital, Herlev, Denmark.

Kaposi Sarcoma (KS) is driven by human herpes virus 8 causing vascular proliferation which is induced by loss of immune function most often due to HIV or immunosuppressants. KS occurs with increased incidence in kidney transplant recipients, but rarely is disseminated. We report a 64-year-old male who developed severely disseminated KS 5 months after ABO-incompatible kidney-transplantation. Read More

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http://dx.doi.org/10.1155/2019/8105649DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6927053PMC
December 2019

Surgical Site Infections Complicating the Use of Negative Pressure Wound Therapy in Renal Transplant Recipients.

Case Rep Transplant 2019 24;2019:2452857. Epub 2019 Sep 24.

Royal Prince Alfred Hospital, Department of Transplantation Services, Sydney, Australia.

Surgical site infections (SSI) of the abdominal wall in renal transplant recipients can on occasion require management with negative pressure wound therapy (NPWT). This is often successful, with a low risk of further complications. However, we describe three cases in which persistent or recurrent surgical site sepsis occurred, whilst NPWT was being deployed in adults with either wound dehiscence or initial SSI. Read More

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http://dx.doi.org/10.1155/2019/2452857DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6778947PMC
September 2019
1 Read

Combined Chylothorax and Chylous Ascites Complicating Liver Transplantation: A Report of a Case and Review of the Literature.

Case Rep Transplant 2019 21;2019:9089317. Epub 2019 Jul 21.

Department of Transplantation Surgery, Henry Ford Hospital, Detroit, MI, USA.

Chyle leaks may occur as a result of surgical intervention. Chyloperitoneum, or chylous ascites after liver transplantation, is rare and the development of chylothorax after abdominal surgery is even more rare. With increasingly aggressive surgical resections, particularly in the retroperitoneum, the incidence of chyle leaks is expected to increase in the future. Read More

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http://dx.doi.org/10.1155/2019/9089317DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6679892PMC
July 2019
3 Reads

Nontraditional Use of TEE to Evaluate Hepatic Vasculature and Guide Surgical Management in Orthotopic Liver Transplantation.

Case Rep Transplant 2019 19;2019:5293069. Epub 2019 Jun 19.

Department of Surgery, Division of Transplant Surgery, Mayo Clinic Arizona, Phoenix, AZ 85054, USA.

Intraoperative Transesophageal Echocardiography (TEE) during orthotopic liver transplant (OLT) is used to gather real-time information on cardiovascular function and intravascular volume status. We report a case where nonstandard TEE views were used to inspect the hepatic vasculature after allograft implantation. A 29-year-old male with secondary biliary cirrhosis with a MELD score of 20 underwent OLT using a liver from a 21-year-old brain-dead donor. Read More

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http://dx.doi.org/10.1155/2019/5293069DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6607703PMC
June 2019
1 Read

Pulmonary Type B Niemann-Pick Disease Successfully Treated with Lung Transplantation.

Case Rep Transplant 2019 16;2019:9431751. Epub 2019 Jun 16.

St Vincent's Hospital Department of Lung Transplant, Sydney, NSW, Australia.

Background: Niemann-Pick Disease (NPD) type B is a rare autosomal recessive disease characterised by hepatosplenomegaly and pulmonary disease, highlighted by preserved volumes and diminished diffusion capacity of the lung for carbon monoxide (DLCO) on pulmonary function tests (PFTs). There is no current accepted treatment for the disease. We present a case of a successful bilateral lung transplant in a patient with a DLCO of 14%, and significant pulmonary changes attributable to NPD type B on computed tomography (CT) chest, and both microscopic and macroscopic assessment of the lung explant. Read More

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http://dx.doi.org/10.1155/2019/9431751DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6601489PMC
June 2019
5 Reads

Mesenchymal Stem Cell Therapy Overcomes Steroid Resistance in Severe Gastrointestinal Acute Graft-Versus-Host Disease.

Case Rep Transplant 2019 21;2019:7890673. Epub 2019 May 21.

Department of Pediatrics, Ehime University Graduate School of Medicine, Ehime, Japan.

The authors describe the high effectiveness of human mesenchymal stem cell (hMSC) therapy to treat steroid-refractory gastrointestinal acute graft-versus-host Disease (aGVHD) in a 15-year-old boy with acute lymphoblastic leukemia (ALL). He received allogeneic hematopoietic stem cell transplantation due to high-risk hypodiploid ALL. Around the time of engraftment, he developed severe diarrhea following high-grade fever and erythema. Read More

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http://dx.doi.org/10.1155/2019/7890673DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6556259PMC
May 2019
11 Reads

Chronically Retained Central Venous Catheter in Deceased Donor Liver Allograft.

Case Rep Transplant 2019 30;2019:4359197. Epub 2019 Apr 30.

Department of Surgery, University of Southern California, Los Angeles, CA, USA.

Central venous catheters (CVC) are commonly used across multiple medical specialties and are inserted for various reasons. A known, but rare, serious complication of CVC is fracture and retention of residual catheter. Here we describe a chronically retained catheter within the inferior vena cava (IVC) that was asymptomatic and neither diagnosed nor addressed until time of deceased donor liver donation. Read More

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http://dx.doi.org/10.1155/2019/4359197DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6515144PMC
April 2019
18 Reads

An Atypical Case of Shiga Toxin Producing- Hemolytic and Uremic Syndrome (STEC-HUS) in a Lung Transplant Recipient.

Case Rep Transplant 2019 11;2019:9465040. Epub 2019 Apr 11.

Service de Néphrologie, Hémodialyse, Aphérèses et Transplantation Rénale, CHU Grenoble-Alpes, Grenoble, France.

We herein describe the first case of thrombotic microangiopathy (TMA) which was related to Shiga toxin producing- Hemolytic and Uremic Syndrome (STEC-HUS) after lung transplantation. His maintenance immunosuppression relied on tacrolimus plus mycophenolic acid. TMA was treated with plasma exchanges (PE) (fresh frozen plasma substitution). Read More

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http://dx.doi.org/10.1155/2019/9465040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6487164PMC
April 2019
9 Reads

Accelerated Oxalosis Contributing to Delayed Graft Function after Renal Transplantation.

Case Rep Transplant 2019 25;2019:8942062. Epub 2019 Mar 25.

Department of Nephrology, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115, USA.

Hyperoxaluria is an important and underrecognized cause for allograft dysfunction and loss after transplantation. It is potentially treatable if recognized in a timely fashion. Research is ongoing to expand the array of therapeutic options available to treat this. Read More

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https://www.hindawi.com/journals/crit/2019/8942062/
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http://dx.doi.org/10.1155/2019/8942062DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6452533PMC
March 2019
23 Reads

Postinfectious Acute Glomerulonephritis in Renal Transplantation: An Emergent Aetiology of Renal Allograft Loss.

Case Rep Transplant 2019 18;2019:7438254. Epub 2019 Mar 18.

Department of Nephrology and Renal Transplantation, Hospital Clínic, University of Barcelona, IDIBAPS, Barcelona, Spain.

Despite the high incidence of posttransplant infections, postinfectious acute glomerulonephritis (PIAGN) in renal allograft is a rare entity, without effective treatment and a bad prognosis. We describe two cases of PIAGN: the first one was developed 2 years after kidney transplantation, secondary to bacteremia with presence of extracapillary proliferation in biopsy. The patient was treated with methylprednisolone and plasma exchanges without response, remaining dialysis dependent. Read More

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http://dx.doi.org/10.1155/2019/7438254DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442439PMC
March 2019
14 Reads

Gastric Mucormycosis in a Renal Transplant Patient Treated with Isavuconazole Monotherapy.

Case Rep Transplant 2019 17;2019:9839780. Epub 2019 Mar 17.

Department of Nephrology, Hypertension and Transplant Medicine, Augusta University Health, Augusta, GA, USA.

Gastrointestinal mucormycosis is a rare infection in solid organ transplant recipients. Our patient, a 79-year-old male, presented with severe dysphagia and odynophagia about 2 weeks after receiving a renal transplant. An upper gastrointestinal (UGI) endoscopy revealed esophagitis and gastric ulceration, the cultures from which grew Rhizopus species. Read More

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http://dx.doi.org/10.1155/2019/9839780DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441519PMC
March 2019
7 Reads

Vascular Reconstructions in Living Unrelated Kidney Transplant Using Donor Ovarian Vein and Recipient Inferior Epigastric Artery with Simultaneous Enucleation of a Complex Cyst.

Case Rep Transplant 2019 13;2019:3272080. Epub 2019 Mar 13.

Department of Surgery, University of Miami Miller School of Medicine, Jackson Memorial Hospital, Miami, FL, USA.

Increasing the organ donor pool and solving the recipient demands continue to be one of the challenges in transplantation. We report our experience in transplanting a living donor kidney requiring complex vascular reconstructions and an enucleation of complex cyst. A 57-year-old male patient underwent a living unrelated kidney transplant. Read More

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https://www.hindawi.com/journals/crit/2019/3272080/
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http://dx.doi.org/10.1155/2019/3272080DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436338PMC
March 2019
20 Reads

Unusual Presentation of Hemophagocytic Lymphohistiocytosis in a Kidney Transplant Patient.

Case Rep Transplant 2019 10;2019:3682378. Epub 2019 Mar 10.

Division of Nephrology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.

We are presenting a case of a middle-aged woman with history of remote kidney transplantation who had multiple admissions for septic shock-like picture, recurrent fever, and hypotension. Her shock manifestation would resolve after stress dose steroid administration and less than 24 hours of vasopressor administration. Initially, extensive workup was performed without revealing etiology. Read More

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http://dx.doi.org/10.1155/2019/3682378DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431471PMC
March 2019
3 Reads

Deceased Donor Renal Transplantation Combined with Bilateral Nephrectomy in a Patient with Tuberous Sclerosis and Renal Failure.

Case Rep Transplant 2019 6;2019:2172163. Epub 2019 Mar 6.

Transplant Surgery Department, Institute for Clinical and Experimental Medicine, Prague, Czech Republic.

Introduction: A 27-year-old female patient with known tuberous sclerosis complex (TSC), polycystic kidneys with multiple large bilateral angiomyolipomas, and failing renal functions with prehemodialysis values (urea: 19 mmol/L; creatinine: 317 mol/L; CKD-EPI 0,27) was admitted to our department for pre-renal transplant evaluation. The patient was placed on the transplant waiting list as the living donor did not pass pretransplant workup and was subsequently contraindicated. Patient was placed on the "cadaverous kidney transplant waiting list". Read More

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http://dx.doi.org/10.1155/2019/2172163DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431358PMC
March 2019
8 Reads

Pyomyositis in a Patient with IgA Nephropathy and Kidney Transplant.

Case Rep Transplant 2019 28;2019:7305683. Epub 2019 Jan 28.

Nephrology and Renal Transplantation Department, Hospital Clinic of Barcelona, Experimental Laboratory in Nephrology and Kidney Transplant (LENIT), Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), University of Barcelona, Spain.

Infections are among the most common complications transplant physicians face when dealing with solid organ transplant recipients. We present a case of pyomyositis caused by in a patient with IgA nephropathy and a kidney transplant, under treatment with mTOR inhibitors and prednisone. This entity is a rare intramuscular infection, given the resistance of healthy muscle to colonization. Read More

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http://dx.doi.org/10.1155/2019/7305683DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6398059PMC
January 2019
4 Reads

Massive Leiomyomatous Uterine Proliferation Following Kidney Transplantation: A Case Report and Literature Review.

Case Rep Transplant 2018 28;2018:3874937. Epub 2018 Nov 28.

Piedmont Hospital Atlanta, Piedmont Transplant Institute, 1968 Peachtree Street NW, 77 Building, 6 Floor, Atlanta, GA 30309, USA.

Uterine fibroids are the most common benign uterine tumors affecting > 50% of premenopausal women. The incidence, burden and symptoms from uterine fibroids are higher in women of African descent compared to Caucasians. Despite increasing number of African American females being evaluated for and undergoing kidney transplantation (KT), perioperative management guidelines for uterine fibroids currently do not exist. Read More

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https://www.hindawi.com/journals/crit/2018/3874937/
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http://dx.doi.org/10.1155/2018/3874937DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304196PMC
November 2018
34 Reads

Life-Threatening Hypertriglyceridemia in a Patient on Ruxolitinib and Sirolimus for Chronic Graft-versus-Host Disease.

Case Rep Transplant 2018 4;2018:4539757. Epub 2018 Nov 4.

Blood and Marrow Transplant Program, Department of Medicine, University of Minnesota, Minneapolis, MN, USA.

Ruxolitinib is an oral selective Janus-associated kinase 1 (JAK1) and JAK2 inhibitor that was initially approved by the FDA in 2014 for treatment of myelofibrosis. In preclinical and retrospective clinical studies, use of ruxolitinib was shown to reduce graft-versus-host-disease (GVHD) in allograft recipients with moderate/severe corticosteroid-dependent or refractory chronic GVHD. While the exact mechanism for action in GVHD is not yet fully understood, prospective studies are ongoing and some patients are receiving ruxolitinib in the setting of steroid refractory GVHD. Read More

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http://dx.doi.org/10.1155/2018/4539757DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6241238PMC
November 2018
5 Reads

Successful Liver Transplantation Case Report from a Deceased Donor with Sickle Cell Anemia.

Case Rep Transplant 2018 22;2018:5154136. Epub 2018 Oct 22.

Liver and Gastrointestinal Transplant Division, Department of Gastroenterology, 05403-900 São Paulo, Brazil.

There is a worldwide problem of waiting time and mortality rate associated with remaining on the waiting list for a liver transplant. However, some situations have been encouraging in terms of determining appropriate recipients and expanding the donor criteria. We herein report a case of useful liver donor with sickle cell anemia for liver transplantation. Read More

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http://dx.doi.org/10.1155/2018/5154136DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6217876PMC
October 2018
8 Reads

Successful Renal Transplantation after Presumed Cyanide Toxicity Treated with Hydroxocobalamin and Review of the Literature.

Case Rep Transplant 2018 9;2018:3753479. Epub 2018 Sep 9.

University of Massachusetts Medical School, Department of Surgery, Division of Organ Transplantation, USA.

We report two cases of successful renal transplantation with allografts from donors who suffered anoxic brain injury as the primary cause of death from house fires. Each was treated prophylactically with hydroxocobalamin (Cyanokit) for suspected cyanide toxicity. During organ procurement, gross examination was notable for deep discoloration of the parenchymal tissues. Read More

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http://dx.doi.org/10.1155/2018/3753479DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6151203PMC
September 2018
58 Reads

Corrigendum to "High on Cannabis and Calcineurin Inhibitors: A Word of Warning in an Era of Legalized Marijuana".

Case Rep Transplant 2018 6;2018:7095846. Epub 2018 Sep 6.

Department of Medicine, Roger Williams Medical Center, Boston University School of Medicine, Providence, RI 02908, USA.

[This corrects the article DOI: 10.1155/2016/4028492.]. Read More

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http://dx.doi.org/10.1155/2018/7095846DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6146556PMC
September 2018
8 Reads

Recurrent Cardiac Myxoma Treated by Orthotopic Heart Transplantation: A Case Report and Literature Review of Heart Transplantation for Primary Cardiac Tumor.

Case Rep Transplant 2018 16;2018:2456949. Epub 2018 Aug 16.

Division of Cardiovascular Medicine, Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.

Primary cardiac myxoma is the most common primary cardiac tumor. Tumor resection is the treatment of choice and overall long-term prognosis is good and recurrence is rare. This report presents a case of a young girl who presented with multiple recurrent cardiac myxoma. Read More

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http://dx.doi.org/10.1155/2018/2456949DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6116406PMC
August 2018
2 Reads

Renal Transplantation with Simultaneous Aortoiliac Reconstruction Using a Polytetrafluoroethylene Vascular Graft for Severe Atherosclerosis.

Case Rep Transplant 2018 31;2018:8959086. Epub 2018 Jul 31.

Surgical Branch, Institute of Kidney Diseases, Jichi Medical University Hospital, Shimotsuke, Japan.

Studies on aortoiliac reconstruction for severe atherosclerosis with renal transplantation are limited. Here, we report a rare experience of the simultaneous reconstruction of the external iliac artery caused by severe atherosclerosis with polytetrafluoroethylene vascular graft and renal transplantation in a 55-year-old female; she was unable to undergo standard renal artery anastomosis to the right external iliac artery because of severe atherosclerosis, which would result in complete occlusion. Next, we directly anastomosed the donor renal artery to the polytetrafluoroethylene graft. Read More

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http://dx.doi.org/10.1155/2018/8959086DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6091454PMC
July 2018
3 Reads

Kidney Transplantation after Extended Multivisceral Resection for Pancreatic Ductal Adenocarcinoma.

Case Rep Transplant 2018 26;2018:3757382. Epub 2018 Jul 26.

Clinic for Surgery, University Clinic Schleswig-Holstein, Campus Lübeck, Lübeck, Germany.

Long-term survival in patients with pancreatic ductal adenocarcinoma (PDAC) is limited. Consequently, solid organ transplantation in PDAC patients is usually not considered. This is the first case report of kidney transplantation (KT) in a 57-year-old female patient after extended multivisceral resection for PDAC of the distal pancreas who had developed end-stage renal disease (ESRD) due to toxic kidney damage by chemotherapy. Read More

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http://dx.doi.org/10.1155/2018/3757382DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6083642PMC
July 2018
4 Reads

Protracted Hypocalcemia following 3.5 Parathyroidectomy in a Kidney Pancreas Recipient with a History of Robotic-Assisted Roux-en-Y Gastric Bypass.

Case Rep Transplant 2018 24;2018:2182083. Epub 2018 Jul 24.

Department of Surgery, Vanderbilt University Medical Center, Nashville, TN, USA.

Background: Hypocalcemia is a frequent complication of parathyroidectomy for secondary/tertiary hyperparathyroidism. In patients with a history of prior Roux-en-Y gastric bypass (RYGBP), changes in nutritional absorption make management of hypocalcemia after parathyroidectomy difficult.

Case Report: A 41-old-year morbidly obese female with c-peptide negative diabetes mellitus and renal failure had RYGBP. Read More

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http://dx.doi.org/10.1155/2018/2182083DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6081600PMC
July 2018
6 Reads

Atypical Neuropsychiatric Presentation in a Patient Expecting Liver Transplantation.

Case Rep Transplant 2018 9;2018:4609631. Epub 2018 Jul 9.

Department of Medicine, Division of Neurology, University Health Network, Pencer Brain Tumour Centre, Princess Margaret Hospital, Canada.

Patients presenting with acute or chronic hepatopathy can develop altered mental status with psychomotor slowing, most commonly indicating encephalopathy. We present the case of a 56-year-old patient who developed subacute atypical neuropsychiatric symptoms including cognitive and behavioural disorganization, manic-like state, and lateralized parkinsonian syndrome. The sequence of events, complete work-up, and detailed neuropsychiatric examination were not compatible with hepatic encephalopathy or delirium; therefore we extended our differential diagnosis and suggested the pathophysiological process described below. Read More

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http://dx.doi.org/10.1155/2018/4609631DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6077324PMC
July 2018
33 Reads

Drug-Induced Liver Injury Associated with the Use of Everolimus in a Liver Transplant Patient.

Case Rep Transplant 2018 18;2018:7410508. Epub 2018 Jul 18.

University of California (UC) San Diego, Skaggs School of Pharmacy and Pharmaceutical Sciences, USA.

Drug-induced liver injury (DILI) has not been previously reported as a complication of treatment with everolimus. A 56-year-old Caucasian male liver transplant recipient developed DILI after receiving everolimus. Elevations in transaminase levels occurred within a week of starting everolimus and an upward trend in the transaminase levels continued with supporting histopathologic changes confirmed by liver biopsy. Read More

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http://dx.doi.org/10.1155/2018/7410508DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6076919PMC
July 2018
57 Reads

Successful Renal Transplantation between Identical Twins with Very Brief Immunosuppression.

Case Rep Transplant 2018 27;2018:9842893. Epub 2018 Jun 27.

Pharmacy, University of Maryland Medical Center, Baltimore, MD, USA.

Renal transplantation between monozygous identical twins provides an opportunity to utilize minimal immunosuppression to maintain stable allograft function, thereby alleviating the toxicities of immunosuppressive therapy. Despite monozygosity, there is a possibility of discordant protein presentation in identical twins that could trigger alloimmune response and lead to graft injury. Therefore, the optimal immunosuppression regimen in this patient population is unknown, and the safety of immunosuppression withdrawal remains controversial. Read More

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http://dx.doi.org/10.1155/2018/9842893DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6040249PMC
June 2018
2 Reads

Inadvertent Traumatic Fracture of Central Venous Catheter during Procurement, Transmitted Through Solid Organ Transplant.

Case Rep Transplant 2018 30;2018:5406098. Epub 2018 May 30.

Department of Transplant Surgery, Einstein Healthcare Network, Philadelphia, PA, USA.

Central venous catheters play a pivotal role in the perioperative support of critically ill patients. They are used for administration of fluids, vasopressors, blood products, and various medications; however, their use may be associated with serious complications, such as catheter fracture and embolization. While most data on catheter fracture embolization consist of isolated case reports, only a few studies have examined patients with central venous catheter embolism. Read More

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http://dx.doi.org/10.1155/2018/5406098DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5998163PMC
May 2018
38 Reads

Nerve Surgery to Treat Intractable Genitofemoral Neuropathic Pain following Laparoscopic Live Kidney Donation.

Case Rep Transplant 2018 6;2018:9326975. Epub 2018 Jun 6.

Department of Transplant Surgery, Leiden University Medical Center, Leiden, Netherlands.

To date live laparoscopic donor nephrectomies (LLDN) are frequently performed. The most common complications entail bleeding, wound infection, and incisional hernia. Here we discuss a 50-year-old patient with a severe less known complication, namely, postoperative persistent neuropathic pain in the scrotum and left upper leg. Read More

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http://dx.doi.org/10.1155/2018/9326975DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6011110PMC
June 2018
31 Reads

De Novo Postinfectious Glomerulonephritis Secondary to Nephritogenic Streptococci as the Cause of Transplant Acute Kidney Injury: A Case Report and Review of the Literature.

Case Rep Transplant 2018 31;2018:2695178. Epub 2018 May 31.

Division of Nephrology-Hypertension, University of California San Diego, San Diego, CA, USA.

Acute kidney injury is common among kidney transplant recipients. Postinfectious glomerulonephritis secondary to nephritogenic streptococci is one of the oldest known etiologies of acute kidney injury in native kidneys but rarely reported among kidney transplant recipients. This report is of a biopsy-proven case of acute kidney injury in a renal allograft recipient caused by de novo poststreptococcal glomerulonephritis. Read More

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http://dx.doi.org/10.1155/2018/2695178DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6000912PMC
May 2018
44 Reads

Absence of Rejection in a Facial Allograft Recipient with a Positive Flow Crossmatch 24 Months after Induction with Rabbit Anti-Thymocyte Globulin and Anti-CD20 Monoclonal Antibody.

Case Rep Transplant 2018 20;2018:7691072. Epub 2018 May 20.

Hansjörg Wyss Department of Plastic Surgery, New York University Langone Health, New York, NY, USA.

Background: Donor-specific antibodies (DSA) to human leukocyte antigen increase the risk of accelerated rejection and allograft damage and reduce the likelihood of successful transplantation. Patients with full-thickness facial burns may benefit from facial allotransplantation. However, they are at a high risk of developing DSA due to standard features of their acute care. Read More

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http://dx.doi.org/10.1155/2018/7691072DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5985128PMC
May 2018
17 Reads

Neutropenic Enterocolitis in a Pediatric Heart Transplant Recipient on Multiple Immunosuppressants.

Case Rep Transplant 2018 8;2018:3264921. Epub 2018 May 8.

UCLA Mattel Children's Hospital, Pediatric Heart Transplant Program, 200 UCLA Medical Plaza Suite 330, Los Angeles, CA 90024, USA.

Neutropenic enterocolitis (NE) historically primarily affects pediatric patients with leukemia who are undergoing chemotherapy or who have recently received bone marrow transplants. Although a few case reports have shown NE occurring outside of this typical population, to our knowledge, this is the first published case of NE occurring in the setting of pediatric heart transplant. This patient was diagnosed several months after pediatric heart transplant, with radiographs showing evidence of pneumatosis intestinalis. Read More

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http://dx.doi.org/10.1155/2018/3264921DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5964482PMC
May 2018
18 Reads

Combination of Modified Bentall Procedure and Orthotopic Liver Transplantation.

Case Rep Transplant 2018 17;2018:6585879. Epub 2018 Apr 17.

Cardiac Surgery, INCCI HaerzZenter, Luxembourg, Luxembourg.

Indication for combined cardiac surgery and orthotopic liver transplantation is rare and patients are at high risks. Individual surgical strategy must be developed since a general standard of such procedure does not exist. We report the case of a 45-year-old woman who underwent simultaneously modified Bentall procedure and orthotopic liver transplantation. Read More

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http://dx.doi.org/10.1155/2018/6585879DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5932520PMC
April 2018
20 Reads

Hepatic Epithelioid Hemangioendothelioma Presenting as an Enlarging Vascular Lesion within the Spleen.

Case Rep Transplant 2018 12;2018:3948784. Epub 2018 Apr 12.

Department of Surgery, University of Alberta, Edmonton, AB, Canada.

Epithelioid hemangioendothelioma (EHE) is a rare vascular neoplasm with variable malignant potential that most often presents within the liver. Many patients present with bilobar or extrahepatic disease, and the current treatment paradigm involves liver transplantation, with favorable long term results. Up to 25% of patients are diagnosed incidentally following imaging for other indications, and confirmation of diagnosis requires histologic analysis, as there are no classical imaging features to distinguish hepatic EHE (HEHE) from other solid hepatic lesions. Read More

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http://dx.doi.org/10.1155/2018/3948784DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5925158PMC
April 2018
24 Reads

Domino Liver Transplantation from a Child with Propionic Acidemia to a Child with Idiopathic Fulminant Hepatic Failure.

Case Rep Transplant 2018 14;2018:1897495. Epub 2018 Mar 14.

Department of Anesthesiology, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY 10463, USA.

Domino liver transplant has emerged as a viable strategy to increase the number of grafts available for transplantation. In the domino transplant organs explanted from one patient are transplanted into another patient. The first successful domino liver transplant was performed in Portugal in 1995. Read More

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http://dx.doi.org/10.1155/2018/1897495DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5872630PMC
March 2018
10 Reads

HSCT-GAVE as a Manifestation of Chronic Graft versus Host Disease: A Case Report and Review of the Existing Literature.

Case Rep Transplant 2018 12;2018:2376483. Epub 2018 Mar 12.

Adult Blood and Marrow Transplant Program, Duke University Medical Center, Durham, NC, USA.

Gastric antral vascular ectasia or "watermelon stomach" is a significant cause of nonvariceal upper GI bleeding and is characterized by red, tortuous ectatic vessels along longitudinal folds in the gastric antrum. The existing literature links GAVE to patients with cirrhosis, scleroderma, bone marrow transplantation, and chronic renal failure among other associations, but its pathophysiology remains ill-defined. Over 30 cases of hematopoietic stem cell transplant-related GAVE (HSCT-GAVE) have been reported in the literature to date and there are likely many more that go undiagnosed or are attributed to another cause of upper gastrointestinal bleeding. Read More

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http://dx.doi.org/10.1155/2018/2376483DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5867646PMC
March 2018
8 Reads