188 results match your criteria Case reports in transplantation[Journal]


Absence of Rejection in a Facial Allograft Recipient with a Positive Flow Crossmatch 24 Months after Induction with Rabbit Anti-Thymocyte Globulin and Anti-CD20 Monoclonal Antibody.

Case Rep Transplant 2018 20;2018:7691072. Epub 2018 May 20.

Hansjörg Wyss Department of Plastic Surgery, New York University Langone Health, New York, NY, USA.

Background: Donor-specific antibodies (DSA) to human leukocyte antigen increase the risk of accelerated rejection and allograft damage and reduce the likelihood of successful transplantation. Patients with full-thickness facial burns may benefit from facial allotransplantation. However, they are at a high risk of developing DSA due to standard features of their acute care. Read More

View Article

Neutropenic Enterocolitis in a Pediatric Heart Transplant Recipient on Multiple Immunosuppressants.

Case Rep Transplant 2018 8;2018:3264921. Epub 2018 May 8.

UCLA Mattel Children's Hospital, Pediatric Heart Transplant Program, 200 UCLA Medical Plaza Suite 330, Los Angeles, CA 90024, USA.

Neutropenic enterocolitis (NE) historically primarily affects pediatric patients with leukemia who are undergoing chemotherapy or who have recently received bone marrow transplants. Although a few case reports have shown NE occurring outside of this typical population, to our knowledge, this is the first published case of NE occurring in the setting of pediatric heart transplant. This patient was diagnosed several months after pediatric heart transplant, with radiographs showing evidence of pneumatosis intestinalis. Read More

View Article

Combination of Modified Bentall Procedure and Orthotopic Liver Transplantation.

Case Rep Transplant 2018 17;2018:6585879. Epub 2018 Apr 17.

Cardiac Surgery, INCCI HaerzZenter, Luxembourg, Luxembourg.

Indication for combined cardiac surgery and orthotopic liver transplantation is rare and patients are at high risks. Individual surgical strategy must be developed since a general standard of such procedure does not exist. We report the case of a 45-year-old woman who underwent simultaneously modified Bentall procedure and orthotopic liver transplantation. Read More

View Article
April 2018
1 Read

Hepatic Epithelioid Hemangioendothelioma Presenting as an Enlarging Vascular Lesion within the Spleen.

Case Rep Transplant 2018 12;2018:3948784. Epub 2018 Apr 12.

Department of Surgery, University of Alberta, Edmonton, AB, Canada.

Epithelioid hemangioendothelioma (EHE) is a rare vascular neoplasm with variable malignant potential that most often presents within the liver. Many patients present with bilobar or extrahepatic disease, and the current treatment paradigm involves liver transplantation, with favorable long term results. Up to 25% of patients are diagnosed incidentally following imaging for other indications, and confirmation of diagnosis requires histologic analysis, as there are no classical imaging features to distinguish hepatic EHE (HEHE) from other solid hepatic lesions. Read More

View Article

Domino Liver Transplantation from a Child with Propionic Acidemia to a Child with Idiopathic Fulminant Hepatic Failure.

Case Rep Transplant 2018 14;2018:1897495. Epub 2018 Mar 14.

Department of Anesthesiology, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY 10463, USA.

Domino liver transplant has emerged as a viable strategy to increase the number of grafts available for transplantation. In the domino transplant organs explanted from one patient are transplanted into another patient. The first successful domino liver transplant was performed in Portugal in 1995. Read More

View Article

HSCT-GAVE as a Manifestation of Chronic Graft versus Host Disease: A Case Report and Review of the Existing Literature.

Case Rep Transplant 2018 12;2018:2376483. Epub 2018 Mar 12.

Adult Blood and Marrow Transplant Program, Duke University Medical Center, Durham, NC, USA.

Gastric antral vascular ectasia or "watermelon stomach" is a significant cause of nonvariceal upper GI bleeding and is characterized by red, tortuous ectatic vessels along longitudinal folds in the gastric antrum. The existing literature links GAVE to patients with cirrhosis, scleroderma, bone marrow transplantation, and chronic renal failure among other associations, but its pathophysiology remains ill-defined. Over 30 cases of hematopoietic stem cell transplant-related GAVE (HSCT-GAVE) have been reported in the literature to date and there are likely many more that go undiagnosed or are attributed to another cause of upper gastrointestinal bleeding. Read More

View Article

Primary Infection Causing a Fluorodeoxyglucose-Avid Right Renal Mass in a Redo Lung Transplant Recipient.

Case Rep Transplant 2018 7;2018:9752860. Epub 2018 Feb 7.

Department of Pulmonary Medicine, Norton Thoracic Institute, St. Joseph's Hospital and Medical Center, Phoenix, AZ, USA.

Immunosuppression after lung transplantation may increase susceptibility to opportunistic infection and is associated with early and delayed deaths in lung transplant recipients. Factors that may predispose lung transplant recipients to opportunistic bacterial and fungal infections include prolonged corticosteroid use, renal impairment, treatment of acute rejection, and post-transplant diabetes mellitus. We present a unique case of a 63-year-old woman with diabetes mellitus who underwent redo lung transplantation. Read More

View Article
February 2018
5 Reads

Liver Transplant for Unusually Large Polycystic Liver Disease: Challenges and Pitfalls.

Case Rep Transplant 2018 1;2018:4863187. Epub 2018 Feb 1.

Department of Surgery, Division of Abdominal Transplant Surgery, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

Patients with polycystic liver disease are described in the literature as both recipient and donor for liver transplant. Due to well-preserved liver function, it is often difficult for these patients to receive an organ. Livers of these patients are often large and heavier than a normal organ. Read More

View Article
February 2018
1 Read

Eculizumab for Thrombotic Microangiopathy Associated with Antibody-Mediated Rejection after ABO-Incompatible Kidney Transplantation.

Case Rep Transplant 2017 28;2017:3197042. Epub 2017 Dec 28.

Department of Nephrology and Transplantation, University Hospital of Strasbourg, Strasbourg, France.

Thrombotic microangiopathy is a form of antibody-mediated rejection (ABMR): it is the main complication of ABO-incompatible (ABOi) kidney transplantation (KT). Herein, we report on two cases of ABMR with biological and histological features of thrombotic microangiopathy (TMA) that were treated by eculizumab after ABOi KT. The first patient presented with features of TMA at postoperative day (POD) 13. Read More

View Article
December 2017
1 Read

Unusual Case of Severe Lactic Acidosis in a Liver Transplant Patient.

Case Rep Transplant 2017 17;2017:3704309. Epub 2017 Dec 17.

Department of Surgery, Drexel University College of Medicine/Hahnemann University Hospital, Philadelphia, PA, USA.

Lactic acidosis is a standard indicator for oxygen debt and some other very significant causes. We describe a case of liver transplant patient presenting with vague abdominal pain and lactic acidosis without any liver dysfunction/failure/ischemia/rejection or sepsis. The imaging studies showed vague bowel edema and normal hepatic perfusion. Read More

View Article
December 2017
3 Reads

Primary Cytomegalovirus Infection Causing Guillain-Barré Syndrome in a Living Renal Allograft Recipient.

Case Rep Transplant 2017 20;2017:7264793. Epub 2017 Nov 20.

Division of Kidney Diseases and Hypertension, North Shore University Hospital and Long Island Jewish Medical Center, Hofstra Northwell School of Medicine, Great Neck, NY, USA.

Guillain-Barré Syndrome (GBS) is a common acute autoimmune polyneuropathy in adults. There have been few reported cases of Guillain-Barré Syndrome associated with active cytomegalovirus (CMV) infection in renal transplant recipients. Here we present a case of active CMV viremia inducing Guillain-Barré Syndrome in a renal transplant recipient. Read More

View Article
November 2017
3 Reads

Unusual Pathology in a Kidney from a Heart-Transplant Patient.

Case Rep Transplant 2017 5;2017:1084718. Epub 2017 Nov 5.

Department of Nephrology and Organ Transplantation, CHU Rangueil, Toulouse, France.

Acute kidney injury (AKI) is often observed after heart transplantation. In this setting, acute tubular necrosis is the main histological finding on kidneys. We report the unusual pathology found in a kidney from a heart-transplant patient. Read More

View Article
November 2017
32 Reads

Gallstone Pancreatitis: A Common but Often Overlooked Cause of Abdominal Pain in Post-Liver-Transplant Patients.

Case Rep Transplant 2017 22;2017:6047046. Epub 2017 Oct 22.

Department of Transplantation, Einstein Medical Center, Philadelphia, PA, USA.

Introduction: In general population, gallstone pancreatitis is the most common cause of pancreatitis. However, there are very few literatures that address this topic in post-liver-transplant patients.

Clinical Case: A 69-year-old female who had a liver transplant in 2015 due to hepatocellular carcinoma and nonalcoholic steatohepatitis (NASH) cirrhosis. Read More

View Article
October 2017
5 Reads

Posttransplant Lymphoproliferative Disease Presenting as an Extracranial Mass.

Case Rep Transplant 2017 11;2017:6401086. Epub 2017 Oct 11.

Department of Medicine, Section of Infectious Diseases, Baylor College of Medicine, Houston, TX, USA.

Posttransplant lymphoproliferative disease is a serious complication following stem cell and solid organ transplantation. Early recognition of the disease is important in facilitating timely therapy and improving long-term outcomes. We report a renal transplant recipient presenting with an extracranial frontoparietal soft tissue mass that was subsequently diagnosed as a B-cell lymphoma. Read More

View Article
October 2017
3 Reads

Incidental Eosinophilic Chromophobe Renal Cell Carcinoma in Renal Allograft.

Case Rep Transplant 2017 9;2017:4232474. Epub 2017 Oct 9.

Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Riyadh, Saudi Arabia.

The incidence of renal cell carcinoma (RCC) in renal allograft in transplant recipients is 0.22-0.25%. Read More

View Article
October 2017
3 Reads

Reconstruction of a Damaged Lower Polar Artery for Kidney Transplantation Using Tubularised Donor Aorta.

Case Rep Transplant 2017 16;2017:3532473. Epub 2017 Oct 16.

Guy's and St Thomas NHS Foundation Trust, Renal Department, London, UK.

Introduction: Live donors, extended donor criteria, and the maximum usage of organs with anatomical variants are some of the mechanisms used to increase the number of organs available.

Case: We present the case of a kidney transplant, in which the organ had an iatrogenic injury to a lower pole arterial branch during retrieval. The donor was a 35-year-old male (DCD, Maastricht III). Read More

View Article
October 2017
3 Reads

Unusual Manifestations of Acute Cytomegalovirus Infection in Solid Organ Transplant Hosts: A Report of Two Cases.

Case Rep Transplant 2017 11;2017:4916973. Epub 2017 Sep 11.

Division of Infectious Diseases, Department of Medicine, University of Illinois at Chicago, Chicago, IL, USA.

Cytomegalovirus (CMV) infection is a common cause of morbidity and mortality in immunocompromised hosts. Tissue-invasive CMV disease causing ulcerative skin disease or esophageal necrosis is rare. We herein describe two cases: a 47-year-old renal and pancreas transplant recipient who presented with skin ulcerations on his elbow and a 50-year-old renal transplant recipient who presented with acute esophageal necrosis. Read More

View Article
September 2017
3 Reads

Collecting Duct Carcinoma of the Native Kidney in a Renal Transplant Recipient.

Case Rep Transplant 2017 14;2017:4527104. Epub 2017 Sep 14.

Department of Surgery, Division of Transplantation, Miami Transplant Institute, University of Miami Miller School of Medicine, Miami, FL 33136, USA.

Collecting duct carcinoma (CDC) is a rare and aggressive form of renal cell carcinoma (RCC) arising from the epithelium of Bellini's duct. It presents earlier in life and has a poorer prognosis than the clear-cell type. Historically, immunosuppressed renal transplant patients are more likely to develop malignancies than the general population. Read More

View Article
September 2017
3 Reads

Tacrolimus Aggravated Tube Feeding Syndrome with Acute Renal Failure in a Pediatric Liver Transplant Recipient.

Case Rep Transplant 2017 20;2017:7345680. Epub 2017 Aug 20.

KUNO University Children's Hospital, Regensburg, Germany.

Acute renal failure can be caused by calcineurin inhibitors (CNIs), due to arteriolopathy and altered tubular function. Within this context, we present the case of a 14-month-old liver transplant recipient who suffered an acute polyuric renal failure during a short episode of hypercaloric feeding. In our case, CNI-induced distal RTA led to nephrocalcinosis and therefore to secondary nephrogenic diabetes insipidus. Read More

View Article
August 2017
6 Reads

Diagnostic Lessons from a Complex Case of Postintestinal Transplantation Enteropathy.

Case Rep Transplant 2017 6;2017:2498423. Epub 2017 Aug 6.

Oxford University Hospitals NHS Foundation Trust, Oxford Transplant Centre, Churchill Hospital, Old Road, Oxford OX3 9DU, UK.

Recent advances in the field of intestinal transplantation have been mitigated by the incidence of allograft rejection. In such events, early identification and appropriate timing of antirejection therapy are crucial in retaining graft function. We present the case of a patient who suffered severe postintestinal transplantation allograft enteropathy, primarily characterized by extensive mucosal ulcerations, and was refractory to all conventional therapy. Read More

View Article
August 2017
3 Reads

Angiosarcoma Developing in an Arteriovenous Fistula after Kidney Transplantation.

Case Rep Transplant 2017 6;2017:2426859. Epub 2017 Aug 6.

Department of Nephrology, Xerencia de Xestión Integrada A Coruña, A Coruña, Spain.

After transplantation, the main concerns involve immunosuppression, the prevention and treatment of infections and graft rejection, and tumor prevention. Sometimes the complications that may appear in the arteriovenous fistula are neglected following kidney transplantation. This is the reason why we are presenting the case of an angiosarcoma developing in an arteriovenous fistula after kidney transplantation. Read More

View Article
August 2017
9 Reads

Spontaneous Renal Allograft Rupture Caused by Acute Tubular Necrosis: A Case Report and Review of the Literature.

Case Rep Transplant 2017 20;2017:9158237. Epub 2017 Jul 20.

Rabindranath Tagore International Institute of Cardiac Sciences, Narayana Health Hospitals, 124 EM Bypass, Mukundapur, Kolkata, India.

Renal allograft rupture (RAR) is a rare but lethal complication of renal transplantation. It potentially threatens graft and patient survival. RAR is frequently associated with acute rejection, but other causes like renal vein thrombosis and acute tubular necrosis have also been observed. Read More

View Article
July 2017
4 Reads

Skin-Limited Graft-versus-Host Disease after Pancreatic Transplantation.

Case Rep Transplant 2017 18;2017:4823870. Epub 2017 Jul 18.

Department of Dermatology, Mayo Clinic, Scottsdale, AZ, USA.

Introduction: The phenomenon of graft-versus-host disease, a solid organ transplant recipient, is a rare development with a very poor prognosis.

Case Presentation: A 40-year-old woman with type 1 diabetes developed cutaneous graft-versus-host disease following second pancreas transplantation.

Conclusion: The development of a nonspecific rash in the early posttransplant period following a pancreas transplant warrants suspicion for graft-versus-host disease. Read More

View Article
July 2017
3 Reads

Successful Use of Ectopic Pelvic Kidney for Living Related Donation Technical Aspects and Literature Review.

Case Rep Transplant 2017 4;2017:8286257. Epub 2017 Jun 4.

Department of Surgery, Division of HPB & Transplant Surgery, Erasmus University Medical Center (Erasmus MC), Rotterdam, Netherlands.

Ectopic pelvic kidneys can provide an additional source of organs for transplantation. They are often excluded from donation in living donation programs mainly due to aberrant vascular and urinary anatomies. We present a donor with an ectopic left kidney, who successfully donated his kidney. Read More

View Article
June 2017
5 Reads

IVIG Associated Aseptic Meningitis in a Renal Transplant Patient.

Case Rep Transplant 2017 23;2017:6962150. Epub 2017 May 23.

Transplant, Urology and Nephrology Directorate, Beaumont Hospital, Dublin 9, Ireland.

The management of antibody-mediated rejection in renal transplant recipients involves plasmapheresis with IVIG. Aseptic meningitis is a rare adverse effect of IVIG therapy and is a diagnosis of exclusion. We report a case of a renal transplant patient who developed IVIG associated aseptic meningitis in the context of management of antibody-mediated rejection, four years after transplantation. Read More

View Article
May 2017
2 Reads

Duodenal Graft Perforation after Simultaneous Pancreas-Kidney Transplantation.

Case Rep Transplant 2017 5;2017:5681251. Epub 2017 Apr 5.

Department of Surgery, Kidney Center, Tokyo Women's Medical University, Tokyo, Japan.

A 45-year-old woman with type 1 diabetes and chronic renal failure on dialysis underwent simultaneous pancreas-kidney transplantation from a brain dead donor. On postoperative day 15, acute generalized peritonitis was diagnosed and emergency laparotomy was performed. Perforation of the donor duodenum was found, which had apparently resulted from duodenal compression by the tip of the intestinal fistula tube placed for decompression. Read More

View Article
April 2017
3 Reads

Successful Treatment of Recurrent Pulmonary Mucormycosis in a Renal Transplant Patient: A Case Report and Literature Review.

Case Rep Transplant 2017 13;2017:1925070. Epub 2017 Mar 13.

Tulane University School of Medicine, Tulane Abdominal Transplant Institute, New Orleans, LA, USA.

We describe the unusual case of a recently transplanted cadaveric renal transplant recipient who presented with recurrent pulmonary mucormycosis. An 18-year-old man with end stage renal disease secondary to congenital renal agenesis status after cadaveric kidney transplant 4 months before presented with acute onset of fever, hemoptysis, and back pain. The patient underwent an emergent left lower lobectomy due to the critical nature of his illness. Read More

View Article
March 2017
5 Reads

Immune Reconstitution Inflammatory Syndrome Occurring in a Kidney Transplant Patient with Extrapulmonary Tuberculosis.

Case Rep Transplant 2017 7;2017:6290987. Epub 2017 Mar 7.

Ocean Renal Associates, 210 Jack Martin Boulevard, Brick, NJ 08724, USA.

Tuberculosis (TB) occurring in solid organ transplantation (SOT) is associated with significant morbidity and mortality usually due to delays in diagnosis, drug toxicity encountered with antimycobacterial therapy, and drug-drug interactions. TB in SOT patients may mimic other infectious and noninfectious posttransplant complications such as posttransplant lymphoproliferative disorder (PTLD) and systemic cytomegalovirus infection. Immune reconstitution inflammatory syndrome (IRIS) is a host response resulting in paradoxical worsening of an infectious disease which occurs after the employment of effective therapy and reversal of an immunosuppressed state. Read More

View Article
March 2017
4 Reads

Brincidofovir Use after Foscarnet Crystal Nephropathy in a Kidney Transplant Recipient with Multiresistant Cytomegalovirus Infection.

Case Rep Transplant 2017 27;2017:3624146. Epub 2017 Feb 27.

Centre de Néphrologie et Transplantation Rénale, Hôpital Conception, Assistance Publique-Hôpitaux de Marseille, Marseille, France.

. Cytomegalovirus (CMV) antiviral drug resistance constitutes an increasing challenge in transplantation. Foscarnet is usually proposed when resistance for ganciclovir is suspected, but its use is limited by its nephrotoxicity. Read More

View Article
February 2017
7 Reads

Successful Treatment of Plasma Cell-Rich Acute Rejection Using Pulse Steroid Therapy Alone: A Case Report.

Case Rep Transplant 2017 10;2017:1347052. Epub 2017 Jan 10.

Division of Nephrology and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan.

Despite the recent development of immunosuppressive agents, plasma cell-rich acute rejection (PCAR) has remained refractory to treatment. Herein, we report an unusual case of PCAR that responded well to pulse steroid therapy alone. A 47-year-old man was admitted for a protocol biopsy three months after kidney transplantation, with a stable serum creatinine level of 1. Read More

View Article
January 2017
13 Reads

Tacrolimus Toxicity due to Biliary Obstruction in a Combined Kidney and Liver Transplant Recipient.

Case Rep Transplant 2017 9;2017:9096435. Epub 2017 Jan 9.

Queensland Renal Transplant Service, Princess Alexandra Hospital, Brisbane, QLD, Australia; School of Medicine, The University of Queensland, Brisbane, QLD, Australia.

The immunosuppressant tacrolimus has a narrow therapeutic window, necessitating therapeutic drug monitoring to maintain efficacy and minimise toxicity. There are very few reports examining the impact of impaired biliary excretion on tacrolimus blood levels or toxicity. We report the case of a 26-year-old combined liver and kidney transplant recipient, who developed acute biliary obstruction leading to tacrolimus toxicity with very high blood tacrolimus levels. Read More

View Article
January 2017
14 Reads

Urinary Obstruction of Transplanted Kidney Caused by Uterine Adenomyosis and 2-Year Posthysterectomy Psoas Abscess in Conjunction with Transplanted Kidney.

Case Rep Transplant 2016 20;2016:7142537. Epub 2016 Dec 20.

Department of Urology, Kanazawa University Hospital, 13-1 Takara-machi, Kanazawa, Japan.

Urinary obstruction of the transplanted kidney caused by uterine leiomyoma is an extremely rare condition. To the best of our knowledge, there are only two reports in English literature. Psoas abscess secondary to renal graft pyelonephritis is also uncommon. Read More

View Article
December 2016
5 Reads

Emergent Management of Intracardiac Thrombosis during Liver Transplantation.

Case Rep Transplant 2016 14;2016:6268370. Epub 2016 Dec 14.

Department of Anesthesia and Perioperative Medicine, Penn State Health Milton S. Hershey Medical Center, Hershey, PA, USA.

Intraoperative thromboembolism is a well-documented complication associated with orthotopic liver transplantation (OLT) but its identification and intraoperative treatment are still an emerging topic in anesthesia. Intracardiac thrombus during OLT is associated with a high mortality rate. There are only a few reports describing the successful management of thromboembolism during OLT. Read More

View Article
December 2016
4 Reads

Scedosporiosis in a Combined Kidney and Liver Transplant Recipient: A Case Report of Possible Transmission from a Near-Drowning Donor.

Case Rep Transplant 2016 13;2016:1879529. Epub 2016 Dec 13.

Weill Cornell Medicine, Cornell University and New York Presbyterian Hospital, New York, NY, USA.

spp. are saprobic fungi that cause serious infections in immunocompromised hosts and in near-drowning victims. Solid organ transplant recipients are at increased risk of scedosporiosis as they require aggressive immunosuppression to prevent allograft rejection. Read More

View Article
December 2016
4 Reads

Successful Stem Cell Transplantation in a Patient with Pretransplant Hepatic Inflammatory Pseudotumour.

Case Rep Transplant 2016 28;2016:6801916. Epub 2016 Nov 28.

Departments of Laboratory Medicine and Haematology-Oncology, National University Cancer Institute, National University Health System, 1E Kent Ridge Road, NUHS Tower Block Level 7, Singapore 119228.

Inflammatory pseudotumours (IPT) are rare benign neoplasms of unknown aetiology. We present a case of hepatic IPT which was incidentally discovered in a patient with relapsed B-acute lymphoblastic leukaemia (B-ALL) undergoing pretransplant workup. After investigation to exclude an infective cause she underwent a reduced intensity conditioning stem cell transplant (SCT) successfully and currently remains well and in remission. Read More

View Article
November 2016
6 Reads

ST Elevation Infarction after Heart Transplantation Induced by Coronary Spasms and Mural Thrombus Detected by Optical Coherence Tomography.

Case Rep Transplant 2016 17;2016:1863869. Epub 2016 Nov 17.

Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark.

The case illustrates the possible link between coronary spasms, intraluminal thrombus formation, and widespread organized and layered thrombi in HTx patients. Furthermore, the case underlines the clinical value of OCT as a novel method for high-resolution vessel imaging in heart-transplanted (HTx) patients with coronary spasms and suspected coronary artery disease. Coronary spasms and sudden death are frequent complications after HTx. Read More

View Article
November 2016
4 Reads

Massive Ascites in a Renal Transplant Patient after Laparoscopic Fenestration of a Lymphocele.

Case Rep Transplant 2016 7;2016:7491627. Epub 2016 Nov 7.

Department of Integrative Cancer Therapy and Urology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan.

Retroperitoneal lymphocele is a common complication of renal transplantation. Here, we report the case of a 67-year-old woman with massive ascites after fenestration surgery for a lymphocele that developed following renal transplantation. She had been on continuous ambulatory peritoneal dialysis for 9 years. Read More

View Article
November 2016
3 Reads

Fatal Donor-Derived Carbapenem-Resistant Infection in a Combined Kidney-Pancreas Transplantation.

Case Rep Transplant 2016 16;2016:7920951. Epub 2016 Oct 16.

Kidney Transplant Unit, IRCCS San Martino University Hospital, IST National Institute for Cancer Research, Genoa, Italy.

Carbapenem-resistant (CR-KP) infections in solid organ transplant recipients are associated with high morbidity and mortality. We report a case of a fatal donor-derived CR-KP infection in a combined kidney-pancreas transplant. Given the short interval of time between donor hospitalization and organ procurement, information concerning the donor CR-KP positivity arrived only 72 hours after transplant. Read More

View Article
October 2016
3 Reads

Immune Complex Mediated Glomerulonephritis with Acute Thrombotic Microangiopathy following Newly Detected Hepatitis B Virus Infection in a Kidney Transplant Recipient.

Case Rep Transplant 2016 9;2016:3152495. Epub 2016 Oct 9.

Departments of Nephrology and Transplantation, Guy's and St Thomas' NHS Foundation Trust, London, UK.

Hepatitis B virus (HBV) presents a risk to patients and staff in renal units. To minimise viral transmission, there are international and UK guidelines recommending HBV immunisation for patients commencing renal replacement therapy (RRT) and HBV surveillance in kidney transplant recipients. We report the case of a 56-year-old male who was immunised against HBV before starting haemodialysis. Read More

View Article
October 2016
5 Reads

Hyperinfection Syndrome Combined with Cytomegalovirus Infection.

Case Rep Transplant 2016 15;2016:1786265. Epub 2016 Sep 15.

Department of Nephrology, Prince Sultan Military Medical City, Riyadh 11159, Saudi Arabia.

The mortality in hyperinfection syndrome (SHS) is alarmingly high. This is particularly common in bone marrow, renal, and other solid organ transplant (SOT) patients, where figures may reach up to 50-85%. Immunosuppressives, principally corticosteroids, are the primary triggering factor. Read More

View Article
September 2016
3 Reads

High on Cannabis and Calcineurin Inhibitors: A Word of Warning in an Era of Legalized Marijuana.

Case Rep Transplant 2016 9;2016:4028492. Epub 2016 Aug 9.

Department of Medicine, Roger Williams Medical Center, Boston University School of Medicine, Providence, RI 02908, USA.

Tacrolimus, a potent immunosuppressant medication, acts by inhibiting calcineurin, which eventually leads to inhibition of T-cell activation. The drug is commonly used to prevent graft rejection in solid organ transplant and graft-versus-host disease in hematopoietic stem cell transplant patients. Tacrolimus has a narrow therapeutic index with variable oral bioavailability and metabolism via cytochrome P-450 3A enzyme. Read More

View Article
September 2016
3 Reads

Preserved Renal Function in Kidney Transplantation over a Thrombosed Aortobifemoral Bypass Graft: The Role of Retrograde Flow and Early Thrombolysis.

Case Rep Transplant 2016 4;2016:6579591. Epub 2016 Aug 4.

Department of Nephrology, Hospital Universitario Ramón y Cajal, Carretera de Colmenar Viejo Km. 9.100, 28034 Madrid, Spain.

Aortobifemoral bypass (ABFB) thrombosis is not uncommon, and when the artery of a renal graft is implanted on a bypass the risk of graft loss is high. We report the case of a 48-year-old woman with a previous history of ABFB under antiplatelet therapy and a kidney allograft implanted on the vascular prosthesis, who presented with acute limb ischemia and severe renal impairment. Imaging techniques revealed a complete thrombosis of the proximal left arm of the ABFB. Read More

View Article
August 2016
7 Reads

Eculizumab for the Treatment of Severe Antibody-Mediated Rejection: A Case Report and Review of the Literature.

Case Rep Transplant 2016 10;2016:9874261. Epub 2016 Jul 10.

Department of Nephrology, Maisonneuve-Rosemont Hospital, Montreal, QC, Canada H1T 2M4.

In renal transplantation, treatment options for antibody-mediated rejection are limited. Here, we report a case of severe AMR treated with eculizumab. A 50-year-old woman known for end stage kidney disease secondary to IgA nephropathy received a kidney transplant from a 50-year-old deceased donor. Read More

View Article
August 2016
5 Reads

Rapid Resolution of Cholangitic Abscess and Biliary Sepsis in a Liver Transplant Recipient after Hepatic Artery Revascularization.

Case Rep Transplant 2016 1;2016:1520849. Epub 2016 Jun 1.

Section of Gastroenterology and Hepatology, Temple University Lewis Katz School of Medicine, Philadelphia, PA 19140, USA.

Hepatic arterial flow is paramount in preserving biliary integrity. We present an interesting clinical scenario of a liver transplant recipient with biliary anastomotic stricture who developed biliary abscess and sepsis after Endoscopic Retrograde Cholangiopancreatography. The abscess did not respond to maximal medical management, percutaneous drainage, and adequate endoscopic biliary drainage. Read More

View Article
June 2016
3 Reads

Early Posttransplant Isolated v1 Lesion Does Not Need to Be Treated and Does Not Lead to Increased Fibrosis.

Case Rep Transplant 2016 17;2016:4603014. Epub 2016 May 17.

Division of Nephrology, University of Arizona, Tucson, AZ 85724, USA.

Acute vascular rejection (AVR) is characterized by intimal arteritis in addition to tubulitis and interstitial inflammation. It is associated with a poorer prognosis compared to tubulointerstitial rejection (AIR) and AVR is associated with a higher rate of graft loss than AIR. The prognosis and treatment of arteritis without tubulitis and interstitial inflammation (isolated v1 lesion) are still controversial. Read More

View Article
June 2016
4 Reads

Application of the Liver Maximum Function Capacity Test in Acute Liver Failure: A Helpful Tool for Decision-Making in Liver Transplantation?

Case Rep Transplant 2016 4;2016:7074636. Epub 2016 May 4.

Department of General, Visceral and Transplant Surgery, Hannover Medical School, 30625 Hannover, Germany.

Background. Despite aggressive intensive medical management acute liver failure (ALF) may require high-urgency liver transplantation (LTx). Available prognostic scores do not apply for all patients; reliable tools to identify individuals in need of LTx are highly required. Read More

View Article
June 2016
4 Reads

False Positive B-Cells Crossmatch after Prior Rituximab Exposure of the Kidney Donor.

Case Rep Transplant 2016 28;2016:4534898. Epub 2016 Apr 28.

Department of Histocompatibility, Amiens University Medical Center, 80000 Amiens, France.

Crossmatching is essential prior to kidney transplantation to confirm compatibility between the donor and the recipient, particularly to prevent acute antibody-mediated rejection. An unexpected positive crossmatch may be obtained in recipients with an autoimmune disease or preexisting antibodies not detected by single-antigen bead array due to complement interference or who have been previously treated by desensitization protocols such as rituximab, antithymocyte globulin, or intravenous immunoglobulins. We report donor and recipient investigations that revealed unexpected positive B-cells crossmatch, probably due to donor cells, as the donor had received rituximab therapy shortly before organ harvesting, in a context of severe idiopathic thrombocytopenic purpura. Read More

View Article
May 2016
5 Reads

First Autologous Cord Blood Therapy for Pediatric Ischemic Stroke and Cerebral Palsy Caused by Cephalic Molding during Birth: Individual Treatment with Mononuclear Cells.

Case Rep Transplant 2016 30;2016:1717426. Epub 2016 Apr 30.

Department of Pediatrics, Ruhr-University Bochum, St. Josef-Hospital, Alexandrinenstrasse 5, 44791 Bochum, Germany; Department of Pediatrics, Evangelisches Krankenhaus Bielefeld, Kinderzentrum Bethel, Grenzweg 10, 33617 Bielefeld, Germany.

Intracranial laceration due to traumatic birth injury is an extremely rare event affecting approximately one newborn per a population of 4.5 million. However, depending on the mode of injury, the resulting brain damage may lead to lifelong sequelae, for example, cerebral palsy for which there is no cure at present. Read More

View Article
May 2016
3 Reads

Lung Transplant Recipient with Pulmonary Alveolar Proteinosis.

Case Rep Transplant 2016 24;2016:4628354. Epub 2016 Apr 24.

Norton Thoracic Institute, St. Joseph's Hospital and Medical Center, Phoenix, AZ 85013, USA.

Pulmonary alveolar proteinosis (PAP) is a progressive lung disease characterized by accumulated surfactant-like lipoproteinaceous material in the alveoli and distal bronchioles. This accumulation is the result of impaired clearance by alveolar macrophages. PAP has been described in 11 solid organ transplant recipients, 9 of whom were treated with mammalian target of rapamycin inhibitors. Read More

View Article
May 2016
7 Reads

Different Management Options for Transplant Ureteral Obstructions within an Inguinal Hernia.

Case Rep Transplant 2016 10;2016:4730494. Epub 2016 Apr 10.

Department of Urology, Stony Brook University Medical Center, Stony Brook, NY 11794, USA; Department of Transplant, Stony Brook University Medical Center, Stony Brook, NY 11794, USA.

Ureteral obstruction secondary to an inguinal hernia with transplant ureteral component is an extremely rare entity with only several case reports found in literature. In all previously reported cases, management of the obstruction involved temporary drainage with ureteral stenting or nephrostomy tube placements followed by delayed definitive repair. We present two case reports, here one being the first one managed by immediate definitive repair via ureteral reimplant and herniorrhaphy and a second case by delayed definitive repair after percutaneous nephrostomy tube placement. Read More

View Article
May 2016
3 Reads