3,233,309 results match your criteria Case reports in surgery[Journal]
J Tissue Eng Regen Med 2018 Dec 16. Epub 2018 Dec 16.
Department of Plastic Surgery, Hand Surgery and Burn Centre, Faculty of Medicine, RWTH University Hospital, Aachen, Germany.
During the last three decades, tissue engineering and reconstructive surgery have become standard therapeutic options in the world of medicine. Several biomaterials, either alone, or in combination with cultured cellular products, have been introduced to compensate for the scarcity of autologous donor tissue or to improve healing in a variety of surgical specialties e.g. Read More
Pain Pract 2018 Dec 16. Epub 2018 Dec 16.
Department of Neurosurgery, Allegheny General Hospital, Pittsburgh, PA.
Loin Pain Hematuria Syndrome (LPHS) is a rare condition characterized by cryptogenic debilitating flank pain and microscopic or macroscopic hematuria. The pathophysiology of LPHS remains poorly understood and diagnosis is made largely by exclusion of alternate pathology. Management strategies can vary widely and include chronic opioid medication and a variety of invasive procedures including regional nerve blocks, transcutaneous electrical nerve stimulation, local capsaicin infusion, and surgical renal denervation. Read More
J Clin Nurs 2018 Dec 16. Epub 2018 Dec 16.
College of Nursing, The Catholic University of Korea, Seoul, Republic of Korea.
Aims And Objectives: The purpose of this study was to analyze the operation, anesthesia, and recovery related factors affecting the occurrence of delirium in the intensive care unit.
Background: The occurrence rate of postoperative delirium is high in surgical patients. Postoperative delirium most frequently occurs usually within 3 days after an operation. Read More
Cytopathology 2018 Dec 16. Epub 2018 Dec 16.
Department of Pathology, Duke University Medical Center.
48-year-old male History of multiple myeloma, clinically stable Now presenting with subcutaneous nodule near the left lateral epicondyle which had been present for "years" but had recently enlarged. The patient noted a possible remote minor trauma to the area. This article is protected by copyright. Read More
Congenit Anom (Kyoto) 2018 Nov 22. Epub 2018 Nov 22.
Department of Developmental Genetics, Institute of Advanced Medicine, Wakayama Medical University (WMU), Wakayama, Japan.
Development of external genitalia and perineum is the subject of developmental biology as well as toxicology and teratology researches. Cloaca forms in the lower (caudal) end of endoderm. Such endodermal epithelia and surrounding mesenchyme interact with various signals to form the external genitalia. Read More
J Surg Oncol 2018 Dec 16. Epub 2018 Dec 16.
Surgical Oncology, Northern Clinical School, The University of Sydney, Sydney, Australia.
Previously important roles for adjuvant radiotherapy (RT) in melanoma patients included improved regional control after resection of high-risk nodal disease, to reduce local recurrence for desmoplastic, and other subtypes of melanoma with neurotropism, reducing in-brain relapse of brain metastases after surgery and other situations on a case-by-case basis. This review evaluates the integration of adjuvant RT into clinical practice at this time of rapidly evolving knowledge and improving outcomes from effective systemic therapy. Read More
Biol Trace Elem Res 2018 Dec 15. Epub 2018 Dec 15.
Pharmaceutical Chemistry, North Branch, Islamic Azad University, Tehran, Iran.
Many periodontal patients may need orthodontic treatment. Alterations in oral environment particularly the reduction of pH in periodontal patients could affect metal ion release from orthodontic appliances. However, there is no study on metal ion release in periodontal patients. Read More
Environ Geochem Health 2018 Dec 15. Epub 2018 Dec 15.
Geological Survey of Slovenia, Dimičeva ulica 14, 1000, Ljubljana, Slovenia.
Street dust (SD) acts as a sink and a source of atmospheric particulate matter, which is especially significant in urban environments. World studies of natural and anthropogenic impacts on the elemental composition of SD are generally limited to specific areas or case studies. The objectives of this study are to determine the impacts of different anthropogenic atmospheric dust emitters and natural factors on the chemical composition of SD, and to define sources of variance in elemental composition of SD, temporal variations and geochemical associations of elements on large number of samples, collected in different time periods, anthropogenic environments and geological settings. Read More
J Chem Ecol 2018 Dec 15. Epub 2018 Dec 15.
Laboratory of Evolutionary Entomology, Institute of Biology, University of Neuchâtel, Emile Argand 11, Case postale 158, 2009, Neuchâtel, Switzerland.
Highbush blueberry is a crop native to the northeast USA that has been domesticated for about 100 years. This study compared the susceptibility of wild and domesticated/cultivated highbush blueberries to an invasive frugivorous pest, the spotted wing drosophila (Drosophila suzukii). We hypothesized that: 1) cultivated fruits are preferred by D. Read More
Neurol Sci 2018 Dec 15. Epub 2018 Dec 15.
Vita-Salute San Raffaele University, Milan, Italy.
Objective: The hexanucleotide repeat expansion in C9orf72 is an associated genetic cause in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). In the "ALS/FTD" spectrum prevails clinical heterogeneity and an in vivo knowledge of the underling brain dysfunction in patients carrying C9orf72 mutation remain limited and only described at group level. The study aimed to assess the brain metabolic alterations characterizing patients with C9orf72 mutation using FDG-PET in single individuals. Read More
Neurol Sci 2018 Dec 15. Epub 2018 Dec 15.
Department of Diagnostics and Applied Technology, Fondazione IRCCS Istituto Neurologico Carlo Besta, Via Celoria 11, 20133, Milan, Italy.
People with epilepsy often suffer psychiatric symptoms or exhibit maladaptive personality characteristics which can impact them more than seizures. This case illustrates a selective association of a Theory of Mind dysfunction, including an impaired comparison of reality and others' behavior, with an obsessive-compulsive personality disorder in a patient with left temporal lobe epilepsy and crossed cognitive functions. The patient revealed visual memory deficits and impaired interpretation of other people's behavior, mental rigidity, and a tendency to formulate inflexible judgements. Read More
Forensic Sci Med Pathol 2018 Dec 15. Epub 2018 Dec 15.
Department of Legal Medicine, Nara Medical University, 840 Shijo-cho, Kashihara, Nara, 634-8521, Japan.
Ventricular septal defect (VSD) generally has a good prognosis unless complicated by heart failure (HF). We report a case of sudden infant death because of clinically undiagnosed VSD in a seemingly healthy 16-day-old boy. Although a cardiac murmur was auscultated at birth, detailed clinical examination was not performed. Read More
Acta Neurol Belg 2018 Dec 15. Epub 2018 Dec 15.
Human Molecular Cytogenetics and Stem Cell Laboratory, Department of Human Genetics and Molecular Biology, Bharathiar University, Coimbatore, Tamil Nadu, 641 046, India.
Autism spectrum disorder is a neurodevelopmental disorder and the cause of autism is still unclear. The aim of this study was to investigate the association of socioeconomic, environmental, pregnancy and newborn-related risk factors among children with autism spectrum disorders. This was a population-based case-control study. Read More
Calcif Tissue Int 2018 Dec 15. Epub 2018 Dec 15.
Centre de référence des erreurs innées du métabolisme, Hôpital d'Enfants, CHRU Nancy, Nancy, France.
Osteoporosis is a common complication of cerebral palsy and Rett's syndrome. It is responsible for multiple fractures, bone pain, and impaired quality of life. In case of Rett's syndrome, a specific dysfunction of osteoblasts causes bone fragility. Read More
Virchows Arch 2018 Dec 15. Epub 2018 Dec 15.
Department of Human Pathology, Graduate School of Medicine, Juntendo University, 2-1-1 Hongo, Bunkyo-Ku, Tokyo, 113-8421, Japan.
Gastric adenocarcinoma with enteroblastic differentiation (GAED) is a rare variant of aggressive adenocarcinoma. We demonstrated previously that GAED is genetically characterized by frequent TP53 mutation. In this study, we aimed to further clarify the mechanism of inactivation of TP53 in GAED in the light of promoter methylation of TP53, and expression of methylation-associated proteins such as Ten-eleven translocation (TET) 1 and 5-hydroxymethylcytosine (5-hmc) in addition to ATM mutations. Read More
Adv Ther 2018 Dec 15. Epub 2018 Dec 15.
Analytical Method Development Team, Samsung Bioepis Co., Ltd., Incheon, South Korea.
Introduction: Tumor necrosis factor (TNF-alpha) inhibitors, such as adalimumab, have shown success in treating autoimmune inflammatory diseases but are associated with substantial financial burdens to the healthcare system. Biosimilars, which are highly similar to biologic agents, offer the potential to reduce the financial burden of treatment. In the case of TNF-alpha inhibitors, they may also offer improved stability and enable prolonged use. Read More
Eat Weight Disord 2018 Dec 15. Epub 2018 Dec 15.
Dietetics and Clinical Nutrition Laboratory, Department of Public Health, Experimental and Forensic Medicine, University of Pavia, Pavia, Italy.
Purpose: Oxidized LDL cholesterol (oxLDL) has been considered as a sensor of oxidative stress (OS) in childhood obesity. We integrated and related our oxLDL existing results previously assessed in overweight/obese children to lifestyle variables to investigate OS-related lifestyle variables.
Methods: 178 Caucasian children/adolescents have been evaluated and according to BMI percentiles have been classified as normal weight (BMI < 75th); overweight (BMI 75-97th) and obese (BMI > 97th). Read More
Rheumatol Int 2018 Dec 15. Epub 2018 Dec 15.
Systemic Autoimmune Diseases Unit, Department of Internal Medicine, Virgen de las Nieves University Hospital, Granada, Spain.
The correct diagnosis, classification and therapeutic management of thrombotic microangiopathies (TMA) continue to be a challenge for the clinician. We report a rare case of eosinophilic granulomatosis with polyangiitis (EGPA) as a trigger for complement-mediated TMA in a 57-year-old man who was successfully treated with corticoids, cyclophosphamide and therapeutic plasma exchange. Additionally, we review few other cases reported in the literature and the pathophysiological pathway of association between TMA and EGPA. Read More
Environ Monit Assess 2018 Dec 15;191(1):21. Epub 2018 Dec 15.
Department of Forest Engineering, Faculty of Forestry, Çankırı Karatekin University, 18200, Çankırı, Turkey.
The benefits of the forests are well known and are by their existence alone an amenity. Nonetheless, urbanization as one of the most remarkable features of social development has immense effects on forest resources and land use. In this study, it is hypothesized that there are temporal interactions among the rural population dynamics, urbanization, and forest resources. Read More
Environ Monit Assess 2018 Dec 15;191(1):19. Epub 2018 Dec 15.
Wrocław University of Environmental and Life Sciences, Institute of Soil Science and Environmental Protection, Grunwaldzka 53, 50-357, Wrocław, Poland.
The legal regulatory/action levels of trace elements in soils are established at high concentrations, at which the crucial functions of soil are at risk or are eliminated. However, concentrations below these action levels, but above presumed natural levels, may also limit particular ecosystem services, including organic food production. Thus, defining the (ambient) background concentrations is an essential part of environmental or health risk assessment, e. Read More
Arch Womens Ment Health 2018 Dec 15. Epub 2018 Dec 15.
Department of Psychology, The Ohio State University, 1835 Neil Avenue, Columbus, OH, USA.
The experience of motherhood is most often emotionally positive and rewarding, but for many new mothers suffering from postpartum depression (PPD), this is not the case. Preclinical and clinical research has sought to uncover brain changes underlying PPD in order to gain a better understanding of how this disorder develops. This review focuses on the mesolimbic dopamine system, particularly the ventral tegmental area-nucleus accumbens pathway which has been implicated in the regulation of critical functions disrupted in PPD including mood, motivation, and mothering. Read More
Graefes Arch Clin Exp Ophthalmol 2018 Dec 16. Epub 2018 Dec 16.
Hôpital d'Instruction des Armées Desgenettes, 108 Boulevard Pinel, 69003, Lyon, France.
Purpose: The main objective of this study was to assess choroidal thickness (CT) changes during an exudative recurrence of age-related macular degeneration (AMD).
Methods: A real-life prospective non-interventional 9-month study was conducted in two centers in consecutive patients with exudative AMD between November 2016 and July 2017. CT was measured manually in both eyes based on enhanced-depth imaging spectral-domain optical coherence tomography at different follow-up visits scheduled in the morning. Read More
Childs Nerv Syst 2018 Dec 15. Epub 2018 Dec 15.
Children's Brain Tumour Research Centre, Academic Division of Child Health, Queen's Medical Centre, University of Nottingham, Nottingham, NG7 2RD, UK.
Purpose: This is the first UK multi-centre case-controlled study with follow-up in excess of 10 years to report the neurocognitive, academic and psychological outcomes of individuals diagnosed with a brain tumour in early childhood. Children enrolled into the UKCCSG CNS 9204 trial, diagnosed with intracranial ependymoma when aged ≤ 36 months old, who received a primary chemotherapy strategy to defer or avoid radiotherapy, were recruited.
Methods: Outcomes of those who relapsed and subsequently received radiotherapy (n = 13) were compared to those enrolled who did not relapse (n = 16), age-matched controls-diagnosed with solid non-central nervous system (SN-CNS; n = 15) tumours or low-grade posterior fossa pilocytic astrocytoma (PFPA; n = 15), and normative data. Read More
Clin Ter 2018 Nov-Dec;169(6):e274-e276
Department of Infectious Diseases, Military Medical Academy, Sofia, Bulgaria.
We present a case of 68-year-old female with four months history of fever, fatigue, and weight loss. She was classified as case of fever of unknown origin. The physical examination was normal, the laboratory tests showed anemia, elevation of C-reactive protein, erythrocyte sedimentation rate and fibrinogen. Read More
Ann Ig 2019 Jan-Feb;31(1):35-44
Department of Science for Health Promotion and Mother to Child Care "G. D'Alessandro", University of Palermo, Italy.
Introduction: Healthcare workers are continuously exposed to the risk of being infected by influenza viruses during their work, thus representing a threat especially for fragile patients. Although the Italian Ministry of Health strongly recommends influenza vaccination for all HCWs, coverage levels in Italy are still far from the expected. Several studies report that one of the preferred strategies to improve vaccination coverage among Healthcare Workers is improving vaccination knowledge through specific multidisciplinary courses. Read More
Ann Ig 2019 Jan-Feb;31(1):3-12
Medical Direction, Bambino Gesù Children's Hospital, Rome, Italy.
Background: Antimicrobial stewardship programs and comprehensive infection control programs represent the main strategies to limit the emergence and transmission of multi-drug resistant bacteria in hospital settings. The purpose of this study was to describe strategies implemented in Italian children's hospitals for controlling antibiotic resistance.
Study Design: Cross sectional multicenter study. Read More
Eur Surg Res 2018 Dec 14;59(5-6):380-390. Epub 2018 Dec 14.
Background: With aging populations increasing in developed countries, the prevalence of elderly patients with hepatocellular carcinoma (HCC) is expected to rise. The aim of this study was to determine the short- and long-term outcomes of HCC surgery in elderly patients (≥75 years) using propensity score matching.
Methods: The study group included 421 patients who underwent hepatectomy as their initial treatment with curative intent. Read More
Nephron 2018 Dec 14:1-6. Epub 2018 Dec 14.
Department of Endocrinology and Metabolism, Institute of Endocrinology, Liaoning Provincial Key Laboratory of Endocrine Diseases, The First Affiliated Hospital of China Medical University, Shenyang,
Hereditary forms of distal renal tubular acidosis (dRTA) are rare and mainly caused by mutations in ATP6V1B1, ATP6V0A4 and SLC4A1. About 20 mutations in SLC4A1 gene have been found that are related to either autosomal dominant (AD) or autosomal recessive dRTA. AD dRTA often manifest as constitutional and can easily be delayed in diagnosis and treatment. Read More
Fetal Diagn Ther 2018 Dec 14:1-10. Epub 2018 Dec 14.
Fetal Medicine Centre, Birmingham Women's and Children's NHS Foundation Trust, Birmingham, United Kingdom.
Background/purpose: We report a case study of jejunal atresia and the results of a systematic literature review of all reported cases of bowel complications occurring after fetoscopic laser ablation (FLA) for the treatment of twin-to-twin transfusion syndrome (TTTS).
Methods: A systematic literature review was performed of bowel complications after FLA for TTTS according to PRISMA guidelines.
Results: There are 11 published cases of small bowel atresia, 5 cases of necrotising enterocolitis (NEC), and 2 cases with foetal bowel perforations. Read More
Respiration 2018 Dec 14:1-7. Epub 2018 Dec 14.
Center for Interstitial and Rare Lung Diseases, Thoraxklinik, University of Heidelberg, Heidelberg,
Background: Transbronchial cryobiopsy (cTBB) may offer an alternative to surgical lung biopsy (SLB) for histopathological diagnosis of interstitial lung diseases (ILDs). However, real-life experience is limited, although case series are increasingly reported.
Objectives: We aimed to evaluate the value of cTBB performed under real-life conditions in a tertiary care center for ILDs. Read More
Oncology 2018 14;95 Suppl 1:5-10. Epub 2018 Dec 14.
Multidisciplinary teams (MDTs) are necessary to deliver the best sarcoma care. Planning the optimal therapeutic strategy per patient requires input and expertise from several disciplines. Case/cohort studies have reported improved patient outcomes associated with treatment by MDTs and/or treatment in sarcoma centres. Read More
Occup Environ Med 2018 Dec 15. Epub 2018 Dec 15.
Department of Immunology-Allergology-Rheumatology, University of Antwerp, Antwerp (Belgium) and Antwerp University Hospital, Antwerp, Belgium.
Objectives: Cannabis allergy has mainly been described following recreational use but some cases also point to cannabis sensitisation as a result of occupational exposure. As a consequence, little is known on the prevalence and clinical phenotype of occupational cannabis allergy. Therefore, this study aims to explore the allergy-associated health risks of occupational cannabis exposure in Belgian police force personnel. Read More
Sex Transm Infect 2018 Dec 15. Epub 2018 Dec 15.
Dermatology Department, Hospital Clínic de Barcelona, Universitat de Barcelona, Barcelona, Spain
Oropharyngeal lymphogranuloma venereum (LGV) is an uncommon presentation and mainly consists of either asymptomatic infections or enlarged cervical lymphadenopathy. According to cross-sectional studies, the prevalence of pharyngeal LGV among men who have sex with men (MSM) seems to be very low. Tissue tropism could explain the difference between rectal and oral mucosa infection frequencies. Read More
Phys Ther Sport 2018 Dec 8;35:133-138. Epub 2018 Dec 8.
Physiotherapy Department, University College of Northern Denmark, UCN, Selma Lagerloffsvej 2, DK-9220, Aalborg, Denmark.
Objectives: Ankle sprains often lead to a history of recurrent injuries and functional joint instability. This study evaluated a new method for assessing functional impairment in patients with chronic ankle instability.
Design: Case-control study for construct validation purpose. Read More
Psychiatry Res 2018 Dec 10;271:559-564. Epub 2018 Dec 10.
Department of Psychology, Faculty of Arts, Dokuz Eylül University, Buca, İzmir, Turkey.
A substantial delay for help-seeking is a serious problem for people with obsessive-compulsive disorder (OCD), a heterogeneous and debilitating mental health condition. Stigma is a major barrier to treatment seeking and further cause social and occupational impairment. Lack of comprehensive research led us to examine the public's stigmatizing attitudes towards checking, contamination, sexuality, aggression, and religion-related OCD symptoms, compared to schizophrenia. Read More
Mult Scler Relat Disord 2018 Dec 1;28:57-59. Epub 2018 Dec 1.
Department of Neurology, San Raffaele Hospital, via Olgettina 48, 20132 Milan, Italy.
Daclizumab, a MS treatment targeting IL2-receptor, has been recently withdrawn following reports of immune-mediated encephalitis. We report the case of a 39-years-old woman treated with daclizumab that presented a progressive decrease in the strength at her lower limbs which further worsened after the drug was stopped. Post-treatment MRI showed more than 20 new enhancing lesions. Read More
Nurse Educ Today 2018 Dec 7;74:31-37. Epub 2018 Dec 7.
Department of Social Psychology, University of Valencia, Valencia, Spain. Electronic address:
Background: Emotional skills are fundamental for quality service by nursing professionals, providing more personalized attention and a close relationship between the professional and patient.
Objectives: To compare linear relationship models (linear regressions) and models based on comparative qualitative analysis (QCA) in the analysis of the possible influence of socio-demographic variables (age and sex), working conditions (type of contract and seniority) and academic training (type of degree and specific training) on emotional abilities (emotional intelligence and empathy) in nursing.
Design: It is a transversal design in a single temporary moment. Read More
Colloids Surf B Biointerfaces 2018 Dec 10;175:314-323. Epub 2018 Dec 10.
Department of Chemistry, Ambedkar National Institute of Technology, Jalandhar, Punjab, India.
Blending of xanthan and acacia gives a unique hybrid that was used for the synthesis of semi-interpenetrating network (semi-IPN) in which poly(acrylamide) chains were grafted onto hybrid of xanthan-acacia followed by their cross-linking (Xan-Aca-cl-poly(AAm)). Optimization was carried out under response surface methodology-central composite design (RSM-CCD). Maximum percentage swelling of semi-IPN obtained was 496. Read More
World Neurosurg 2018 Dec 13. Epub 2018 Dec 13.
Department of Neurosurgery, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Rae Bareli Road, Lucknow, India.
Background: Pathological laughter is inappropriate, involuntary and unmotivated laughter episodes which may or may not be associated with mirth or amusement. Though associated with many diffuse brain pathologies, its association with intracranial focal mass lesions causing ventrolateral brainstem compression like petroclival meningioma is very rare. The exact pathophysiology of this interesting and unusual clinical symptom is unknown but probably involves disinhibition and release of the so-called coordination center located in the upper brainstem due to compression by the tumor. Read More
J Pharm Biomed Anal 2018 Dec 10;165:207-212. Epub 2018 Dec 10.
Department of Experimental Medicine, University of Campania "L. Vanvitelli", Via S. M. di Costantinopoli, 16, 80138, Naples, Italy.
An innovative complementary approach using a liquid chromatographic-mass spectrometer method and infrared spectroscopy is proposed for measuring internal biological exposure to dangerous chemical contaminants and for monitoring biochemical changes in target organs. The proposed methodologies were validated and applied in the case of rats exposed to low-doses of Bisphenol A (BPA). A liquid chromatographic method coupled to a tandem mass spectrometer was used in order to measure BPA concentration in rat livers. Read More
Leuk Res 2018 Dec 5;76:48-52. Epub 2018 Dec 5.
Hematology, Department of Translation and Precision Medicine, "Sapienza" University of Rome, Italy; Hematology Unit, S. Maria Goretti Hospital, AUSL Latina, Italy. Electronic address:
We compared 2-[fluorine-18] fluoro-2-deoxy-d-glucose PET-CT and contrast-enhanced computed tomography (CECT) in 62 consecutive patients with newly diagnosed Hodgkin Lymphoma (HL), aiming to provide evidences that may spare CECT from the staging procedures of HL patients. Among a total of 1448 nodal sites examined, disease involvement was detected in 232 (16%) and 280 (19.3%) nodal areas by CECT and PET-CT, respectively (P < 0. Read More
Int J Pharm 2018 Dec 13. Epub 2018 Dec 13.
Institute of Pharmacy, Faculty I of Natural Sciences, Martin Luther University Halle-Wittenberg, Wolfgang-Langenbeck-Str. 4, 06120, Halle/Saale, Germany. Electronic address:
Polymers functionally contribute to supersaturation and precipitation inhibition of the active pharmaceutical ingredient (API) in amorphous solid dispersions (ASD). Therefore, it is necessary to monitor physicochemical changes of the polymeric carrier caused by the manufacturing process. This is especially important when the material is exposed to heat and shear stress as in case of hot-melt extrusion (HME). Read More
Osteoarthritis Cartilage 2018 Dec 13. Epub 2018 Dec 13.
Department of Physical Therapy, High Point University, High Point, North Carolina, USA. Electronic address:
Objective: To investigate the clinical- and cost-effectiveness at 2-year follow-up of providing individual, supervised exercise physiotherapy and/or manual physiotherapy in addition to usual medical care.
Method: People with hip or knee osteoarthritis meeting the American College of Rheumatology clinical diagnostic criteria were randomised (1:1, concealed, assessor-blinded) to 4 groups: usual medical care; supervised exercise physiotherapy; manual physiotherapy; or combined exercise and manual physiotherapy. Physiotherapy group participants were provided 10 50-minute treatment sessions including booster sessions at 4 and 13 months, in addition to usual care. Read More
Ecotoxicol Environ Saf 2018 Dec 13;170:427-435. Epub 2018 Dec 13.
State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, PR China; College of Resources and Environment, University of Chinese Academy of Sciences, Beijing 100190, PR China; Institute of Environment and Health, Jianghan University, Wuhan 430056, PR China. Electronic address:
Regional haze episode has already caused overwhelming public concern. Unraveling the health effects of the representative composition mixtures of atmospheric fine particulate matters (PM) becomes a top priority. In this study, a novel computational solution integrating chemical-induced genomic residual effect prediction with in vitro-based risk assessment is proposed to obtain the cumulative health risk of typical chemical mixtures of particulate matters (PM). Read More
Clin Microbiol Infect 2018 Dec 13. Epub 2018 Dec 13.
Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, China; Key Laboratory of Obstetric & Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, Sichuan University, Chengdu, China. Electronic address:
Background: Effective diagnostic methods for detecting latent tuberculosis infection (LTBI) are important for its eradication. A number of studies have evaluated the use of interferon gamma-induced protein 10 (IP-10), which is elevated after tuberculosis infection, as a biomarker for LTBI, but conclusive results regarding its effectiveness have not been reported.
Objectives: Our objective was to assess the diagnostic value of IP-10 for LTBI. Read More
Eur J Pharm Sci 2018 Dec 13. Epub 2018 Dec 13.
Chemistry Department, Gedeon Richter Plc, Gyömrői út 19-21, 1107 Budapest, Hungary. Electronic address:
The present study was aimed to develop an in vitro non-cell-based method, for the measurement of corneal permeability. To this avail, the parallel artificial membrane permeability assay (PAMPA) was used for studying the effects of composition of the artificial lipid membrane, the DMSO cosolvent content of the donor phase as well as different buffer solutions in the model. Based on experimental corneal permeability values of 25 active pharmaceutical ingredients (APIs), a final model with good predictive ability (R = 0. Read More
J Shoulder Elbow Surg 2018 Dec 13. Epub 2018 Dec 13.
Department of Orthopaedic Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Background: Shoulder arthroscopy is a common orthopedic procedure typically performed on an outpatient basis. Occasionally, patients require an unplanned hospital admission. An understanding of the incidence and risk factors for admission after shoulder arthroscopy may assist surgeons in determining which patients may be susceptible to unplanned admission after surgery. Read More
J Clin Lipidol 2018 Nov 3. Epub 2018 Nov 3.
Department of Paediatric Medicine, Amsterdam UMC, University of Amsterdam, the Netherlands.
Background: Homozygous familial hypercholesterolemia (HoFH) is a rare genetic disorder that may cause life-threatening cardiovascular disease (CVD) at childhood. Marginal effectiveness of statins in reducing low-density lipoprotein cholesterol (LDL-C) is the reason why extracorporeal removal of LDL-C by lipoprotein apheresis (LA) is recommended at the earliest possible age.
Objective: It is, however, unknown to what extent LA effectively reduces the burden of CVD in children with HoFH. Read More
J Theor Biol 2018 Dec 13. Epub 2018 Dec 13.
Department of Mathematics, Kennesaw State University, 370 Paulding Ave. NW Kennesaw. GA 30144, UK.
Modelling enzyme kinetics has a long history, as one of the earliest areas where mathematics was utilized to understand biological (in this case, biochemical) phenomena. By using differential equations and the law of mass action, many researchers have discovered information about the mechanisms of enzyme workings in the more than 100 years since Leonor Michaelis and Maud Menten published their classic paper in 1913. This work uses the laws obeyed by molecules during a reaction, translates them into mathematical equations, and then compares the results predicted by the equations to data obtained in laboratory conditions. Read More