360 results match your criteria Case reports in rheumatology[Journal]


Abatacept in the Treatment of Juvenile Dermatomyositis-Associated Calcifications in a 16-Year-Old Girl.

Case Rep Rheumatol 2020 28;2020:4073879. Epub 2020 May 28.

Division of Infectious Diseases, Department of Pediatrics, Valley Children's Hospital, Madera, CA, USA.

Calcinosis is a feared complication of JDM that may be seen in up to 40% of children with JDM. It is associated with negative impact on the patients' quality of life due to weakness, functional disability, joint contractures, muscle atrophy, skin ulcers, and secondary infections. Calcinosis can present as superficial nodules or plaques, larger nodular deposits extending into deeper tissue layers, accumulation of calcifications along the fascial planes of muscles or tendons, or an exoskeleton of calcium leading to limitations in mobility and joint contractures. Read More

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http://dx.doi.org/10.1155/2020/4073879DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7275234PMC

Familial Mediterranean Fever Complicated by a Triad of Adrenal Crisis: Amyloid Goiter and Cardiac Amyloidosis.

Case Rep Rheumatol 2020 19;2020:7865291. Epub 2020 May 19.

Medicine Department, Ahli Hospital, Hebron, Palestine, Israel.

Background: FMF is a common disease in the Mediterranean populations and may be complicated by AA amyloidosis. The coexistence of adrenal and thyroid amyloidosis in AA amyloidosis secondary to familial Mediterranean fever (FMF) is an extremely rare reported condition. We presented a previously unreported triad of adrenal, thyroid, and cardiac amyloidosis secondary to FMF. Read More

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http://dx.doi.org/10.1155/2020/7865291DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7256690PMC

Severe Pulmonary Hypertension as Initial Presentation of SLE: A Case Report and Literature Review.

Case Rep Rheumatol 2020 15;2020:6014572. Epub 2020 May 15.

Department of Internal Medicine, University of South Dakota, Vermillion, SD, USA.

Severe pulmonary artery hypertension (PAH) is a rare initial presentation of systemic lupus erythematosus (SLE). SLE associated with PAH carries worse prognosis that isolated SLE. However, there has been improvement in mortality of the patients in the recent years owing to newer treatment options available. Read More

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http://dx.doi.org/10.1155/2020/6014572DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7245690PMC

Synovitis, Acne, Pustulosis, Hyperostosis, and Osteitis Syndrome with Purely Osteolytic, Not Osteosclerotic, Lesions Mimicking a Malignant Tumor.

Case Rep Rheumatol 2020 28;2020:6316921. Epub 2020 Mar 28.

Department of Orthopedic Surgery, Chiba Cancer Center, 666-2 Nitonacho, Chuo-ku, Chiba 260-8717, Japan.

Synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome is a rare inflammatory disorder with multiple phenotypes. The syndrome has identifiable radiologic characteristics that are the most important when making a diagnosis. X-rays of cases diagnosed with SAPHO syndrome reveal sclerotic lesions or mixed lytic and sclerotic lesions. Read More

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http://dx.doi.org/10.1155/2020/6316921DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7142334PMC

Complete Regression of Giant Aneurysms in an Infant with Delayed Diagnosis and Refractory Kawasaki Disease via Combination Anticytokine Therapy: Case Report and Review of Similar Cases.

Case Rep Rheumatol 2020 28;2020:6249013. Epub 2020 Mar 28.

Division of Allergy, Immunology and Rheumatology, Children's Hospital of San Antonio, Baylor College of Medicine, 333 N Santa Rosa St, San Antonio, TX, USA.

Background: Kawasaki disease (KD) is an inflammatory vasculitis and is the most common cause of acquired childhood heart disease in developed countries. Current treatment with intravenous immunoglobulin (IVIG) is often ineffective in patients with delayed or refractory disease. We present a case of combination anticytokine therapy in an infant with delayed and refractory KD. Read More

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http://dx.doi.org/10.1155/2020/6249013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7142349PMC

Pyoderma Gangrenosum as a Presenting Feature of Undifferentiated Spondyloarthropathy with Erosive Inflammatory Arthritis.

Case Rep Rheumatol 2020 26;2020:1848562. Epub 2020 Mar 26.

Department of Rheumatology, University of Florida Health, 653 W 8 Street, Jacksonville, 32209 Florida, USA.

Pyoderma gangrenosum is a rare inflammatory condition with varying clinical presentations and severity. It is commonly seen in association with an underlying condition, most common of which is inflammatory bowel disease. We report a case of a 26-year-old male who came to the emergency department with increasing lower extremity ulcers, intermittent hematochezia, and pain in the small joints of his hands. Read More

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http://dx.doi.org/10.1155/2020/1848562DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7136808PMC

Influence of the Period of Abstinence on Semen Quality in a Patient with Systemic Lupus Erythematosus: A Case Report and Review of the Literature.

Case Rep Rheumatol 2020 7;2020:9296858. Epub 2020 Mar 7.

Assisted Reproductive Technology Unit, Department of Obstetrics and Gynecology, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China.

Systemic lupus erythematosus (SLE) is a chronic inflammatory disease that can affect fertility. There is currently little information regarding the semen profile of males with SLE. Moreover, there is no consensus on an appropriate period of sexual abstinence for semen analysis and on the use of DNA fragmentation assay, together with multiple semen analyses to document the semen profile in this clinical population. Read More

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http://dx.doi.org/10.1155/2020/9296858DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7085386PMC

Systemic Lupus Erythematosus with Multiple Autoimmune Disease Presented with Extensive Peripheral Gangrene.

Case Rep Rheumatol 2020 10;2020:8278275. Epub 2020 Mar 10.

An-Najah National University, Faculty of Medicine & Health Sciences, Nablus, State of Palestine.

Systemic lupus erythematosus (SLE) is an autoimmune disease and can be associated with other autoimmune diseases. SLE usually presents with skin change and rarely presents with gangrene. SLE gangrene usually involves the digits of upper extremities. Read More

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http://dx.doi.org/10.1155/2020/8278275DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7085827PMC

Acute Symptomatic Calcific Discitis Mimicking a Septic Spondylodiscitis.

Case Rep Rheumatol 2020 9;2020:5454197. Epub 2020 Mar 9.

Department of Rheumatology, Henri Mondor University Hospital, Paris XII University-UPEC, Créteil, France.

Acute symptomatic calcific discitis is a poorly understood condition that has been mostly reported in children. Cases in adults have been scarcely reported and may mimic an infectious process. Imaging, including computed tomography, can show the disc calcification but might fail to show it because its resorption can occur early after the onset of symptoms. Read More

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http://dx.doi.org/10.1155/2020/5454197DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7085383PMC

Apixaban as a Rare Cause of Leukocytoclastic Vasculitis.

Case Rep Rheumatol 2020 26;2020:7234069. Epub 2020 Feb 26.

Department of Medicine, Pennsylvania Hospital, University of Pennsylvania Health System (UPHS), Philadelphia, PA, USA.

Apixaban is a rare cause of leukocytoclastic vasculitis (LCV). To our knowledge, there is only one other reported case due to apixaban in the literature. We present a case of apixaban-induced leukocytoclastic vasculitis in a 95-year-old male. Read More

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http://dx.doi.org/10.1155/2020/7234069DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7063214PMC
February 2020

Successful Treatment of Pulmonary Arterial Hypertension in Systemic Sclerosis with Anticentriole Antibody.

Case Rep Rheumatol 2020 25;2020:1926908. Epub 2020 Feb 25.

Department of Hematology and Rheumatology, Tohoku University Graduate School of Medicine, Aoba-ku, Sendai, Japan.

Systemic sclerosis (SSc) is characterized by skin sclerosis and multiple organ damages which may cause mortality and is usually accompanied with several specific autoantibodies, each of which is associated with characteristic complications. Among them, anticentriole antibody is recently reported to be highly associated with SSc-associated pulmonary arterial hypertension (SSc-PAH). In general, several vasodilators are used as therapeutic drugs for SSc-PAH, whereas immunosuppressive therapies are not. Read More

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http://dx.doi.org/10.1155/2020/1926908DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7061130PMC
February 2020

Pulmonary Onset of Adult Onset Still's Disease Complicated with Kikuchi Lymphadenitis.

Case Rep Rheumatol 2020 19;2020:8327068. Epub 2020 Feb 19.

University Medical Unit, Teaching Hospital Karapitiya, Galle, Sri Lanka.

Background: Adult onset Still's disease (AOSD) is a rare inflammatory disorder with a variety of clinical presentations. Even though pneumonitis and pleurisy are known to occur in AOSD, pulmonary onset presentations are exceedingly rare. . Read More

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http://dx.doi.org/10.1155/2020/8327068DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7053467PMC
February 2020

Hemorrhagic Stroke in Relapsing Polychondritis: A Rare Complication of a Rare Disease.

Case Rep Rheumatol 2020 21;2020:7464503. Epub 2020 Feb 21.

University of Illinois College of Medicine at Peoria, Peoria, Illinois, USA.

Background: Relapsing Polychondritis is a rare rheumatologic condition with multisystem involvement. Common presenting symptoms are auricular and nasal chondritis. Common complications include hearing loss and cardiac involvement. Read More

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http://dx.doi.org/10.1155/2020/7464503DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7056989PMC
February 2020

Leflunomide-Induced Hidradenitis Suppurativa.

Case Rep Rheumatol 2020 18;2020:3549491. Epub 2020 Feb 18.

Department of Dermatology, Mohammed V Military Hospital, Mohammed V University of Rabat, Rabat, Morocco.

Hidradenitis suppurativa is an inflammatory disease of the pilosebaceous unit with a chronic intermittent course and a devastating effect on quality of life. Rare reports of drug-induced hidradenitis suppurativa exist. We report on 2 women on follow-up for rheumatoid arthritis, who presented hidradenitis suppurativa after different periods of treatment with leflunomide and who improved few weeks after discontinuation of the medication. Read More

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http://dx.doi.org/10.1155/2020/3549491DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7049404PMC
February 2020

PL-7 Antisynthetase Syndrome in Association with Sjögren's, Systemic Lupus Erythematosus, and Rheumatoid Arthritis.

Case Rep Rheumatol 2020 13;2020:4736476. Epub 2020 Feb 13.

WellStar Kennestone Regional Medical Center, Marietta, GA 30060, USA.

We present a rare case of PL-7 antisynthetase syndrome (ASS) in association with Sjögren's, systemic lupus erythematosus (SLE), and seropositive rheumatoid arthritis (RA). Initially, the patient was diagnosed with Sjögren's followed by Sjögren's/SLE overlap and then Sjögren's/SLE/RA overlap. She was eventually diagnosed with Sjögren's/SLE/RA overlap with PL-7 ASS with interstitial lung disease (ILD). Read More

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http://dx.doi.org/10.1155/2020/4736476DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7042534PMC
February 2020

Multiple Myeloma Mimicking a Small Vessel Vasculitis Presentation.

Case Rep Rheumatol 2020 12;2020:9146842. Epub 2020 Feb 12.

Rheumatologist, Hospital General de Medellín, Medellín, Colombia.

Multiple myeloma can have different clinical manifestations, and not all patients present with classic CRAB component. We describe a 46-year-old woman admitted to our hospital with a complaint of a bluish-to-black discoloration of the second toe that was rapidly progressive and acute kidney injury. We documented a Kappa light chain monoclonal gammopathy, increased presence of plasmacytes in bone marrow aspiration, and multiple lytic bone lesions, which led to a diagnosis of multiple myeloma. Read More

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http://dx.doi.org/10.1155/2020/9146842DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7037530PMC
February 2020

Trauma Induced Calcium Pyrophosphate Deposition Disease of the Lumbar Spine.

Case Rep Rheumatol 2020 10;2020:3218350. Epub 2020 Feb 10.

SUNY Upstate University Hospital, Syracuse, NY-13210, USA.

Inflammatory arthritis, such as pseudogout or otherwise referred to as calcium pyrophosphate (CPP) crystal arthritis or calcium pyrophosphate deposition (CPPD) disease, is characterized by the deposition of crystal formation and deposition in large joints. CPPD is known to affect the elderly population and commonly manifests as inflammation of knees, hips, and shoulders. CPPD disease involving the spine has been infrequently encountered in practice and rarely described in the literature. Read More

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http://dx.doi.org/10.1155/2020/3218350DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7035534PMC
February 2020

Platelet Rich Plasma for Treatment of Rheumatoid Arthritis: Case Series and Review of Literature.

Case Rep Rheumatol 2020 31;2020:8761485. Epub 2020 Jan 31.

Emirates Integra Medical & Surgery Centre, Dubai, UAE.

Platelet-rich plasma (PRP) is an autologous blood product with platelets above circulating levels and releases several growth factors after activation. PRP may help to decrease joint inflammation by modulating synovial cell proliferation and differentiation and inhibition of catabolic pathways in various articular conditions. Though PRP has shown good efficacy in osteoarthritis and other musculoskeletal conditions such as synovitis, epicondylitis, skeletal muscle injuries, and tendinopathy, there is limited experience for the use of PRP in patients with rheumatoid arthritis. Read More

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http://dx.doi.org/10.1155/2020/8761485DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7021456PMC
January 2020

A Patient with Complex Gout with an Autoinflammatory Syndrome and a Sternoclavicular Joint Arthritis as Presenting Symptoms.

Case Rep Rheumatol 2020 31;2020:5026490. Epub 2020 Jan 31.

Centro Medico, Chiasso, Switzerland.

A 50-year-old man presented to the emergency department with widespread pain, especially at the chest level, fever, and night sweats. Physical examinations revealed a swelling with localized pain in the left sternoclavicular joint. Laboratory tests showed a CPR of 134 mg/l and an ESR of 70 mm/h. Read More

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http://dx.doi.org/10.1155/2020/5026490DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7013360PMC
January 2020

Ankylosing Spondyloarthritis Resulting Severe Aortic Insufficiency and Aortitis: Exacerbation of Ankylosing Spondyloarthritis and Stenosis of the Main Left Coronary Artery after Mechanical Aortic Valve Implantation with Cardiopulmonary Bypass.

Case Rep Rheumatol 2020 3;2020:9538527. Epub 2020 Jan 3.

Institute of Cardiology of the Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania.

Ankylosing spondyloarthritis (AS) is a chronic inflammatory rheumatic disease, strongly related to human leukocyte antigen (HLA)-B27. Cardiac involvement in AS manifests in 2 to 10% of patients as aortic insufficiency, aortitis, mitral valve fibrosis, or disturbance in the conduction of the heart. In this article, we present a case of a 49-year-old male patient with AS, who was referred to our medical institution for elective aortic valve surgery because of severe aortic regurgitation. Read More

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http://dx.doi.org/10.1155/2020/9538527DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6964718PMC
January 2020

Microscopic Polyangiitis with Pulmonary Fibrosis: An Often-Recognized Manifestation of the Disease.

Case Rep Rheumatol 2019 31;2019:2673947. Epub 2019 Dec 31.

Department of Clinical Immunology and Allergy, Royal North Shore Hospital, Sydney, NSW, Australia.

Background: Microscopic polyangiitis (MPA) can manifest with atypical features such as pulmonary fibrosis and chronic obstructive pulmonary disease (COPD), which are atypical and unusual features of small vessel vasculitis.

Case Presentation: This paper presents two patients with microscopic polyangiitis and respiratory symptoms attributable to atypical pulmonary manifestations. Pulmonary fibrosis was present in both cases, with COPD also present in one patient. Read More

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http://dx.doi.org/10.1155/2019/2673947DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6955142PMC
December 2019

Systemic Lupus Erythematosus (SLE) with Acute Nephritis, Antineutrophil Cytoplasmic Antibody- (ANCA-) Associated Vasculitis, and Thrombotic Thrombocytopenic Purpura (TTP): A Rare Case Report with Literature Review.

Case Rep Rheumatol 2019 14;2019:8750306. Epub 2019 Dec 14.

Oakland University William Beaumont School of Medicine, 586 Pioneer Dr, Rochester, MI 48309, USA.

Thrombotic thrombocytopenic purpura (TTP) is a potentially fatal disorder that requires urgent identification and treatment. The association of TTP with systemic lupus erythematosus (SLE) and vasculitis has been reported, however, never simultaneously. A 33-year-old woman with a history of SLE presented with acute abdominal pain, fever, arthralgias, and skin rash. Read More

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http://dx.doi.org/10.1155/2019/8750306DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6942753PMC
December 2019

A Case of Diffuse Alveolar Hemorrhage Associated with High-Titer of MPO-ANCA Demonstrating Cytoplasmic Staining Pattern.

Case Rep Rheumatol 2019 12;2019:6074792. Epub 2019 Dec 12.

Division of Rheumatology, SUNY Upstate Medical University, 750 East Adams Street, Syracuse, NY 13210, USA.

Diffuse alveolar hemorrhage (DAH) is a life-threatening complication of ANCA-associated vasculitis (AAV) that requires urgent recognition and treatment. A presumptive diagnosis is often rendered without histopathology if concordant positivity of ANCA by indirect immunofluorescence (IIF) and ELISA assays, i.e. Read More

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http://dx.doi.org/10.1155/2019/6074792DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6930762PMC
December 2019

Chronic Inflammatory Arthropathy Preceding Acute Systemic Manifestations of Sarcoidosis: A Possible Overlap of Idiopathic Juvenile Arthritis and Sarcoidosis.

Case Rep Rheumatol 2019 7;2019:6483245. Epub 2019 Dec 7.

Nephrology Service, Cassiano Antonio de Moraes Hospital, Federal University of Espírito Santo (HUCAM/UFES), Vitória, ES, Brazil.

Sarcoidosis is a multisystem disease with unknown etiology, marked by T lymphocytes and macrophages agglomeration, which leads to the formation of noncaseating granulomas in the affected tissues. We describe a case of a 40-year-old black patient referred to our service for evaluation of nephrolithiasis and persistent elevation of plasma creatinine. He reported important weight loss, fever episodes, and abdominal and low back intermittent pain in the past 6 months. Read More

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http://dx.doi.org/10.1155/2019/6483245DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6925795PMC
December 2019

Resolution of Osseous Sarcoidosis with Methotrexate.

Case Rep Rheumatol 2019 11;2019:4156313. Epub 2019 Nov 11.

University of Vermont Medical Center, The Robert Larner, M. D. College of Medicine at the University of Vermont, Burlington, VT, USA.

Though a relatively uncommon manifestation of sarcoidosis, some clinicians are tasked with managing osseous involvement of disease, and the optimal treatment approach in this setting is not well established. Previous studies have shown variable efficacy for osseous sarcoidosis utilizing multiple agents alone or in combination, often using imaging follow-up in conjunction with clinical assessment to evaluate response to treatment. We present a case of widespread skeletal involvement of sarcoidosis without evidence of concurrent pulmonary disease demonstrating marked clinical improvement and near-complete resolution of imaging abnormalities on magnetic resonance imaging (MRI) following the use of methotrexate as the primary pharmacologic agent. Read More

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http://dx.doi.org/10.1155/2019/4156313DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6925686PMC
November 2019

Alveolar Hemorrhage, a Rare and Life-Threatening Complication of Catastrophic Antiphospholipid Syndrome.

Case Rep Rheumatol 2019 13;2019:3284258. Epub 2019 Nov 13.

Internal Medicine, Eugenio Espejo Hospital, Quito, Ecuador.

Alveolar hemorrhage is the rarest pulmonary complication of catastrophic antiphospholipid syndrome and is associated with high mortality risk. This life-threatening complication results from autoimmune damage to the alveolar blood vessels. Given the limited literature addressing the association of these two pathologies, we report a series of three cases with this complication and then compare our findings with 6 cases reported in the literature. Read More

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http://dx.doi.org/10.1155/2019/3284258DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6877973PMC
November 2019

Rituximab-Induced Psoriasis in a Patient with Granulomatosis with Polyangitis Treated with Adalimumab.

Case Rep Rheumatol 2019 17;2019:5450863. Epub 2019 Oct 17.

Rheumatology Unit, Department of Medicine, King Saud University, Riyadh, Saudi Arabia.

Rituximab (RTX) is a chimeric B-cell-depleting monoclonal antibody against CD-20 positive cells that has been approved for the induction and maintenance of granulomatosis with polyangiitis (GPA). Reports have identified RTX to cause drug-related psoriasis. Many theories of underlying pathways have been proposed. Read More

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http://dx.doi.org/10.1155/2019/5450863DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6855024PMC
October 2019

A Case of Severe Seronegative Inflammatory Arthritis due to Nivolumab and Review of the Literature.

Case Rep Rheumatol 2019 3;2019:1326734. Epub 2019 Nov 3.

Department of Rheumatic & Immunologic Disease, Cleveland Clinic Foundation, Cleveland, Ohio, USA.

Immune-checkpoint inhibitors (ICIs) have revolutionized the treatment of cancer, yet therapy is often hampered by immune-related adverse events (irAEs) which range from mild to severe life-threatening events. Musculoskeletal (MSK) irAEs leading to discontinuation of ICIs are uncommon but increasingly recognized. We report a challenging case of severe immune-related seronegative inflammatory arthritis due to nivolumab in a patient with stage IV metastatic adenocarcinoma. Read More

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http://dx.doi.org/10.1155/2019/1326734DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6875374PMC
November 2019

Seronegative Arthritis and Whipple Disease: Risk of Misdiagnosis in the Era of Biologic Agents.

Case Rep Rheumatol 2019 13;2019:3410468. Epub 2019 Oct 13.

Rheumatology Clinic, Department of Medical Area, Academic Hospital Santa Maria della Misericordia, University of Udine, Udine, Italy.

We report 2 cases of Whipple disease (WD), previously diagnosed as seronegative polyarthritis and treated for several years with immunosuppressive agents, accordingly. Both cases had been treated over years with cDMARDs and bDMARDs. The first patient was a 48-year-old male, who developed a life-threatening disease characterized by fever, significant weight loss, and bloody diarrhoea, supported with RBC transfusions. Read More

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http://dx.doi.org/10.1155/2019/3410468DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6815603PMC
October 2019

Clinical and Diagnostic Considerations for Atypical, Adult Onset Presentation of Chronic Recurrent Multifocal Osteomyelitis (CRMO).

Case Rep Rheumatol 2019 29;2019:8206892. Epub 2019 Sep 29.

West Virginia University Medicine, 1 Medical Center Drive, Morgantown, WV 26506, USA.

Chronic recurrent multifocal osteomyelitis (CRMO) is the most severe form of chronic nonbacterial osteomyelitis (CNO) and is a rare autoinflammatory bone disorder that mostly affects children and adolescents. CRMO is a diagnosis of exclusion, resulting in often-delayed diagnosis with over one year on average from onset of symptoms to time of diagnosis. Initial diagnosis is rare in adults and previously undocumented in the elderly (age greater than 65). Read More

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http://dx.doi.org/10.1155/2019/8206892DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6791280PMC
September 2019
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The Central Nervous System Effects and Mimicry of Common Variable Immunodeficiency (CVID): A Case Report with Literature Review.

Case Rep Rheumatol 2019 29;2019:7623643. Epub 2019 Sep 29.

Rheumatology, Beaumont Hospital, Royal Oak 48073, MI, USA.

There is a scarceness of information on the central nervous system effects of common variable immunodeficiency (CVID). A 30-year-old woman with a history of recurrent upper respiratory infections, vitiligo, and immune thrombocytopenic purpura presented with right-sided numbness. Magnetic resonance imaging (MRI) of the thoracic spine revealed a signal hyperintensity. Read More

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http://dx.doi.org/10.1155/2019/7623643DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6791247PMC
September 2019
1 Read

Systemic Lupus Erythematosus Presented with Bilateral Orbital Edema and Negative Serology.

Case Rep Rheumatol 2019 23;2019:7140534. Epub 2019 Sep 23.

Registrar, Internal Medicine Department, Dermatology, King Hamad University Hospital, AL-Muharraq, Bahrain.

Isolated bilateral periorbital edema with negative serology is an extremely rare presentation of cutaneous lupus erythematosus that may lead to eyelid scarring, infection, or even corneal involvement. The treatment usually comprises a combination of hydroxychloroquine and a tapering dose of systemic steroids. Patients require long-term follow-up as they may develop systemic lupus erythematosus with positive serology later in life. Read More

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http://dx.doi.org/10.1155/2019/7140534DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6778949PMC
September 2019
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Combined Left Central Retinal Artery Occlusion and Bilateral Anterior Ischemic Optic Neuritis: A Rare Presentation of Giant Cell Arteritis.

Case Rep Rheumatol 2019 22;2019:3236821. Epub 2019 Sep 22.

Department of Ophthalmology, Teaching Hospital Jaffna, Jaffna, Sri Lanka.

Giant cell arteritis, a large vessel vasculitis is characterized by headache, visual impairment, constitutional symptoms, and increased inflammatory markers. Visual involvement in giant cell arteritis ranges from amaurosis fugax to permanent visual loss, and extensive bilateral visual impairment is a rare presentation. We hereby report a case of combined left central retinal artery occlusion and bilateral anterior ischemic optic neuritis in a patient who poorly responded to standard corticosteroid therapy. Read More

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http://dx.doi.org/10.1155/2019/3236821DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6778950PMC
September 2019
1 Read

An Autopsy Case of a 5-Year-Old Child with Acute Pancreatitis Caused by Eosinophilic Granulomatosis with Polyangiitis-like Necrotizing Vasculitis.

Case Rep Rheumatol 2019 2;2019:9053747. Epub 2019 Sep 2.

Department of Diagnostic Pathology, Seirei Mikatahara Hospital, 3453 Mikataharacho, Hamamatsu 433-8558, Japan.

In children, acute pancreatitis has been reported in IgA vasculitis, Kawasaki disease, systemic lupus erythematosus-associated vasculitis, and juvenile dermatomyositis-associated vasculitis. However, its frequency in these vasculitides has been shown to be low. In other childhood-onset vasculitides, acute pancreatitis is seldom reported. Read More

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http://dx.doi.org/10.1155/2019/9053747DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6745468PMC
September 2019
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Pleomorphic Pulmonary Manifestations of IgG4-Related Disease.

Case Rep Rheumatol 2019 20;2019:7572869. Epub 2019 Aug 20.

Medical Oncologist, Ashland Bellefonte Cancer Center, Ashland, KY, USA.

Immunoglobulin G4-related disease (IgG4-RD) is a fibroinflammatory disorder which has been first reported in 2001 by Hamano and colleagues in a patient with autoimmune sclerosing pancreatitis. Almost every organ in the human body can be affected by IgG4-RD from infiltration with IgG4-positive plasma cells. Involvement of lungs with IgG4 is reported previously, but still, there is no clear picture of the pathophysiology behind lung involvement. Read More

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http://dx.doi.org/10.1155/2019/7572869DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6721390PMC

Nephrotic Syndrome due to Focal Segmental Glomerulosclerosis Complicating Sjögren's Syndrome: A Case Report and Literature Review.

Case Rep Rheumatol 2019 15;2019:1749795. Epub 2019 Aug 15.

Department of Nephrology, Nagano Red Cross Hospital, 5-22-1 Wakasato, Nagano 380-8582, Japan.

Background: Renal tubular acidosis and tubulointerstitial nephritis constitute the primary renal complications associated with Sjögren's syndrome (SjS), and glomerulonephritis and nephrotic syndrome are rare.

Case Presentation: A 79-year-old Japanese woman presented with bilateral leg edema and weight gain and was diagnosed with nephrotic syndrome. In addition, she reported a 5-year history of dryness of mouth and was diagnosed with SjS. Read More

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http://dx.doi.org/10.1155/2019/1749795DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6714328PMC
August 2019
4 Reads

Diffuse Alveolar Hemorrhage in a Patient with Antisynthetase Syndrome.

Case Rep Rheumatol 2019 31;2019:5453717. Epub 2019 Jul 31.

Mexican Medical School, La Salle University, Mexico City, Mexico.

An alveolar hemorrhage case is reported as the initial manifestation of antisynthetase syndrome in a 40-year-old man, who is admitted to the Emergency Department for diagnostic approach of chronic cough and progressive dyspnea. The diagnosis of the alveolar hemorrhage was based on the presence of acute respiratory failure, decrease in hemoglobin levels, and observation of macrophages filled with hemosiderin. The antisynthetase syndrome was classified through a tomographic image compatible with a nonspecific interstitial pneumonia, along with antibodies associated to myositis (PL-12 and Ro-52). Read More

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http://dx.doi.org/10.1155/2019/5453717DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6701415PMC
July 2019
1 Read

Liquid Silicone-Induced Extensive and Debilitating Granulomatosis Responding to Hydroxychloroquine.

Case Rep Rheumatol 2019 24;2019:8173790. Epub 2019 Jul 24.

Board Certified in Internal Medicine and Geriatric, Primary Care Physician, Department of Medicine, Lincoln Medical Center, Bronx, NY, USA.

In the last two decades, there has been a significant rise in body-image improvement among the American consumers. Cosmetic injectable procedures have increased by 40.6% in the past 5 years. Read More

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http://dx.doi.org/10.1155/2019/8173790DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6681618PMC
July 2019
1 Read

Ultrasound-Proven Severe Synovitis Induced by PD-1 Inhibitor Therapy in a Patient Predisposed to Seronegative Inflammatory Arthritis.

Case Rep Rheumatol 2019 24;2019:7340692. Epub 2019 Jul 24.

Departments of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.

A 71-year-old Japanese woman was treated with programmed cell death protein-1 (PD-1) inhibitor, nivolumab, for renal cell carcinoma with lung metastasis. Although she had been treated with antirheumatic drugs from 40 to 60 years old by the diagnosis of seronegative inflammatory arthritis, treatment was discontinued based on her achievement of remission. She developed severe polyarthralgia after the administration of nivolumab. Read More

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http://dx.doi.org/10.1155/2019/7340692DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6681606PMC
July 2019
1 Read

Systemic Lupus Erythematosus Presenting as Myopericarditis with Acute Heart Failure: A Case Report and Literature Review.

Case Rep Rheumatol 2019 24;2019:6173276. Epub 2019 Jul 24.

Department of Medicine, Jamaica Hospital Medical Center, 8900 Van Wyck Expressway, Jamaica, NY 11418, USA.

Acutely decompensated dilated cardiomyopathy in a middle-aged patient without the typical risk factor profile presents a clinical dilemma. While cardiomyopathy is a known aspect of systemic lupus erythematosus (SLE), initial clinical presentation as decompensated dilated cardiomyopathy (DCM) is exceedingly rare in the literature. We share the case of a 49-year-old African-American female with no past medical history who presented with overt heart failure of 4 weeks evolution. Read More

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https://www.hindawi.com/journals/crirh/2019/6173276/
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http://dx.doi.org/10.1155/2019/6173276DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6681595PMC
July 2019
4 Reads

A Case of Heparin-Induced Thrombocytopenia That Developed in the Therapeutic Course of Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis.

Case Rep Rheumatol 2019 22;2019:2724304. Epub 2019 Jul 22.

Department of Nephrology, Nagano Red Cross Hospital, 5-22-1 Wakasato, Nagano 380-8582, Japan.

Background: Heparin-induced thrombocytopenia (HIT) causes thrombocytopenia via an immunological mechanism, resulting in severe organ injury due to arterial-venous thrombosis. HIT often develops in hemodialysis patients owing to heparin use. Anti-neutrophil cytoplasmic antibody-associated vasculitis (AAV) is a systemic vasculitis, and cases of AAV complicated with HIT are rare. Read More

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http://dx.doi.org/10.1155/2019/2724304DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6679837PMC
July 2019
2 Reads

Fifty-Two-Week Results of Clinical and Imaging Assessments of a Patient with Rheumatoid Arthritis Complicated by Systemic Sclerosis with Interstitial Pneumonia and Type 1 Diabetes despite Multiple Disease-Modifying Antirheumatic Drug Therapy That Was Successfully Treated with Baricitinib: A Novel Case Report.

Case Rep Rheumatol 2019 9;2019:5293981. Epub 2019 Jul 9.

The First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.

Baricitinib is a Janus kinase 1/2 (JAK1/2) inhibitor used in the treatment of rheumatoid arthritis. A 71-year-old woman with rheumatoid arthritis complicated by systemic sclerosis and type 1 diabetes that were resistant to multiple disease-modifying antirheumatic drugs started treatment with baricitinib. After baricitinib administration, the disease activity of her rheumatoid arthritis was attenuated from the early stage of treatment, and the effect was maintained for up to 52 weeks. Read More

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http://dx.doi.org/10.1155/2019/5293981DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6652034PMC
July 2019
3 Reads

A Case of Severe Symptomatic Central Nervous System Sarcoidosis Secondary to Treatment with Adalimumab.

Case Rep Rheumatol 2019 16;2019:7121539. Epub 2019 Jun 16.

Department of Rheumatology, Berkshire Medical Center, Pittsfield, Massachusetts, USA.

Antitumor necrosis factor- therapy has been used effectively in treatment of many inflammatory diseases such as rheumatoid arthritis, psoriasis, psoriatic arthritis, ankylosing spondylitis, and inflammatory bowel disease. There are increasing number of paradoxical reactions associated with this therapy that are being reported. We present the case of a 63-year-old male with psoriatic arthritis maintained on adalimumab and methotrexate (previous treatment trials of prednisone and leflunomide) who developed severe symptomatic sarcoidosis in the brain, liver, and lung. Read More

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http://dx.doi.org/10.1155/2019/7121539DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6604474PMC
June 2019
4 Reads

A Case Report of Takayasu's Arteritis and Ulcerative Colitis in a Pediatric Patient with Chronic Recurrent Multifocal Osteomyelitis Successfully Treated with Infliximab: Diagnostic Clues in Disease Associations and Immune Dysregulation.

Case Rep Rheumatol 2019 11;2019:8157969. Epub 2019 Jun 11.

Department of Pediatrics, University at Buffalo, Oishei Children's Hospital, 1001 Main Street, Buffalo, NY 14203, USA.

Background: Takayasu's arteritis with comorbid chronic recurrent multifocal osteomyelitis and ulcerative colitis is rare in the pediatric population. Treatment with anti-TNF alpha agents such as infliximab has been a successful treatment strategy in adults and can be used effectively in the pediatric population.

Case Presentation: We present the case of a 15-year-old Caucasian girl with a history of chronic recurrent multifocal osteomyelitis and ulcerative colitis presenting with hypertensive emergency secondary to Takayasu's arteritis with middle aortic syndrome. Read More

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http://dx.doi.org/10.1155/2019/8157969DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6594285PMC
June 2019
3 Reads

Mixed Cryoglobulinemia in a Patient with Juvenile Idiopathic Arthritis.

Case Rep Rheumatol 2019 6;2019:5858106. Epub 2019 Jun 6.

Department of Rheumatology, Specialized Medical Center Hospital, Riyadh, Saudi Arabia.

Cryoglobulinemia is a rare illness of cryoglobulin accumulation in the blood which can typically present with arthralgia, purpura, skin ulcers, glomerulonephritis, and peripheral neuropathy. It is classified as mixed cryoglobulinemia when cryoglobulins contain more than one immune component such as IgM rheumatoid factor and polyclonal IgG. Typically, it presents in the setting of clonal hematologic disease, viral infection, or certain connective tissue diseases. Read More

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http://dx.doi.org/10.1155/2019/5858106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6590528PMC
June 2019
5 Reads

Genital Ulcer of Behçet Disease Localized in the Vagina May Lack Pain, Making It Difficult to Assess.

Case Rep Rheumatol 2019 10;2019:2953676. Epub 2019 Jun 10.

Perinatal Center for Maternity and Neonates, Yokohama City University Medical Center, Yokohama, Japan.

Genital ulcer is one of the main clinical symptoms of Behçet disease; ulcers mostly occur in the vulva and are usually quite painful. We present an unusual case of Behçet disease wherein a painless genital ulcer was localized in the vagina. Our case is of a 43-year-old woman diagnosed with Behçet disease that was controlled with prednisolone. Read More

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http://dx.doi.org/10.1155/2019/2953676DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6590484PMC
June 2019
7 Reads

Destructive Upper Airway Disease from Eosinophilic Granulomatosis with Polyangiitis (EGPA): The Very First Case.

Case Rep Rheumatol 2019 23;2019:6173869. Epub 2019 May 23.

Division of Pulmonary and Critical Care Medicine, Albany Medical Center, Albany, NY, USA.

Eosinophilic granulomatosis with polyangiitis (EGPA) is a multisystem vasculitic disorder that predominantly affects medium- and small-sized blood vessels. EGPA belongs to a group of vasculitides known as anti-neutrophil cytoplasmic antibody- (ANCA-) associated vasculitis (AAV). Upper airway involvement is seen in all ANCA-associated vasculitides, but destructive upper airway disease has never been reported in patients with EGPA. Read More

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http://dx.doi.org/10.1155/2019/6173869DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6556304PMC
May 2019
3 Reads

Chronic Myeloid Leukemia in a Patient Receiving Tofacitinib: A Case Report and Literature Review.

Case Rep Rheumatol 2019 27;2019:2814504. Epub 2019 May 27.

Internal Medicine Department, St George Hospital University Medical Center and the University of Balamand, Beirut, Lebanon.

Background: Tofacitinib is a new oral Janus kinase inhibitor that has shown promising clinical benefit in various rheumatologic diseases. However, many concerns related to the development of malignancies have been reported with its use.

Case Presentation: A 43-year-old female patient received tofacitinib for refractory rheumatoid arthritis (RA). Read More

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http://dx.doi.org/10.1155/2019/2814504DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6556791PMC
May 2019
6 Reads

Simultaneous Oculomotor and Facial Nerve Palsies in a Patient with Systemic Lupus Erythematosus and Sjögren's Syndrome.

Case Rep Rheumatol 2019 11;2019:4156781. Epub 2019 Apr 11.

Division of Rheumatology and Clinical Immunology, Department of Medicine, Jichi Medical University, Shimotsuke, Tochigi, Japan.

A 70-year-old man with systemic lupus erythematosus (SLE) presented with simultaneous right oculomotor nerve palsy and right facial nerve palsy. Brain magnetic resonance imaging and cerebrospinal fluid analysis revealed no abnormality. Coexistent Sjögren's syndrome was diagnosed on the basis of anti-SS-A antibody positivity, salivary gland scintigraphy, and histological findings on minor salivary gland biopsy. Read More

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http://dx.doi.org/10.1155/2019/4156781DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6487149PMC
April 2019
7 Reads

Severe Disabling Myalgia as an Initial Presentation of Polyarteritis Nodosa.

Case Rep Rheumatol 2019 7;2019:4364289. Epub 2019 Apr 7.

Professor in Medicine, Department of Internal Medicine, Faculty of Medicine, University of Ruhuna, Galle, Sri Lanka.

Background: Polyarteritis nodosa (PAN) is a form of necrotizing vasculitis affecting medium or small blood vessels with multiorgan involvement. Although myalgia is a clinical feature of PAN, severe disabling myalgia as the initial presentation is rarely noted.

Case Presentation: We present a case of 54-year-old male with recently detected chronic kidney disease admitted with progressive severe disabling muscular pains predominantly over calves with constitutional symptoms for seven weeks. Read More

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http://dx.doi.org/10.1155/2019/4364289DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6476074PMC
April 2019
9 Reads