1,148 results match your criteria Case reports in oncology[Journal]


Promising Combination Therapy with Bevacizumab and Erlotinib in an EGFR-Mutated NSCLC Patient with MET Amplification Who Showed Intrinsic Resistance to Initial EGFR-TKI Therapy.

Case Rep Oncol 2019 Jan-Apr;12(1):91-97. Epub 2019 Jan 21.

Division of Medical Oncology, Department of Internal Medicine, Teikyo University School of Medicine, Tokyo, Japan.

In lung cancer, several potential mechanisms of intrinsic and acquired resistance to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) have been explored, including mesenchymal-epithelial transition factor (MET) signaling pathway activation. On the other hand, vascular endothelial growth factor (VEGF) production of EGFR-mutated lung cancer cells is stimulated by predominantly activated MET signaling pathway. Therefore, the inhibition of VEGF axis as the downstream target of MET signaling pathway seems promising. Read More

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http://dx.doi.org/10.1159/000493088DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381877PMC
January 2019
3 Reads

Need for Flexible Adjustment of the Treatment Schedule for Aprepitant Administration against Erlotinib-Induced Refractory Pruritus and Skin Rush.

Case Rep Oncol 2019 Jan-Apr;12(1):84-90. Epub 2019 Jan 21.

Division of Medical Oncology, Department of Internal Medicine, Teikyo University School of Medicine, Tokyo, Japan.

Common dermatological side-effects associated with erlotinib, epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI), include pruritus and skin rash, which are mediated by substance P, leading to the occasional discontinuation of cancer treatment. Aprepitant is an antagonist of neurokinin-1 receptor, through which substance P activates the pruritogens. Thus, aprepitant is expected to offer a promising option for the treatment of erlotinib-induced pruritus. Read More

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http://dx.doi.org/10.1159/000493256DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381921PMC
January 2019
4 Reads

Long-Term Follow-Up after Surgical Management for Atypical Endometriosis: A Series of Nine Cases.

Case Rep Oncol 2019 Jan-Apr;12(1):76-83. Epub 2019 Jan 21.

Department of obstetrics and gynecology, Nara Medical University, Nara, Japan.

Background And Objective: Atypical endometriosis is reported to possess a precancerous potential attributed to premalignant changes characterized by cytological atypia and architecture proliferation. Although the coexistence of atypical endometriosis and neoplasms has been reported, cases of atypical endometriosis transformation to carcinoma are rarely reported. The purpose of this case series was to evaluate the prognosis of atypical endometriosis. Read More

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http://dx.doi.org/10.1159/000496178DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381887PMC
January 2019
1 Read

Significance of Earlier Initiation of Chemotherapy for Lung Cancer Complicated with Primary or Secondary Nephrotic Syndrome following Its Appropriate Differential Diagnosis.

Case Rep Oncol 2019 Jan-Apr;12(1):53-58. Epub 2019 Jan 11.

Division of Medical Oncology, Department of Internal Medicine, Teikyo University School of Medicine, Tokyo, Japan.

We encountered a case of primary lung cancer complicated with membranous nephropathy as primary nephrotic syndrome. Because treatment approaches vary greatly for primary and secondary nephrotic syndrome, a renal biopsy was performed for diagnosis. Much time was required to make a definitive diagnosis of primary nephrotic syndrome, as opposed to paraneoplastic nephrotic syndrome. Read More

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http://dx.doi.org/10.1159/000493851DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381920PMC
January 2019
1 Read

Successful Treatment with Taxane-Based Chemotherapy in Advanced Sebaceous Carcinoma: A Case Report and Literature Review.

Case Rep Oncol 2019 Jan-Apr;12(1):47-52. Epub 2019 Jan 11.

Division of Medical Oncology, Department of Internal Medicine, Teikyo University School of Medicine, Tokyo, Japan.

For sebaceous carcinoma (SC), a rare malignant tumor, no standard chemotherapy regimen for patients with distant metastasis has been studied. We experienced a case of eyelid SC with multiple lung metastases that responded to combination chemotherapy with carboplatin and paclitaxel with 11-month progression-free survival (PFS). This patient also responded to second-line treatment with docetaxel, another taxane, with 7-month PFS, resulting in at least 18 months of survival at the time of reporting. Read More

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http://dx.doi.org/10.1159/000493850DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381883PMC
January 2019
1 Read

Intracardiac Extension of Wilms Tumor: A Case of a 2.5-Year-Old Girl Presenting with Upper Venous Congestion Caused by Tumor Growth into the Right Cardiac Ventricle.

Case Rep Oncol 2019 Jan-Apr;12(1):33-38. Epub 2019 Jan 4.

Department of Urology, University of Heidelberg, Heidelberg, Germany.

While Wilms tumors (WT) typically present solely with an abdominally palpable mass, rare cases exhibiting vascular tumor growth can also present with circulatory problems. Here, we report the case of a 2.5-year-old girl presenting with upper venous congestion and arterial hypertension as the primary symptoms of intraventricular tumor growth exhibiting remarkable tubular and perfused morphology. Read More

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http://dx.doi.org/10.1159/000496020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381912PMC
January 2019
2 Reads

Nivolumab Induced Lethal Aplastic Anemia in a Patient with Metastatic Melanoma.

Case Rep Oncol 2019 Jan-Apr;12(1):29-32. Epub 2019 Jan 4.

Department of Oncology, Soroka University Medical Center, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel.

Nivolumab is an active treatment in patients with metastatic melanoma. We report a case of a patient with metastatic malignant melanoma who was given nivolumab as an advanced-line treatment. She received nivolumab 3 mg/kg every 2 weeks for 4 cycles and developed aplastic anemia. Read More

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http://dx.doi.org/10.1159/000495980DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381922PMC
January 2019
3 Reads

A Mosquito Bite with Devastating Complications in an Immunocompromised Patient.

Case Rep Oncol 2019 Jan-Apr;12(1):22-28. Epub 2019 Jan 4.

Klinik für Innere Medizin II, Hämatologie und internistische Onkologie, Universitätsklinikum Jena, Jena, Germany.

Infectious complications such as invasive aspergillosis or infection with (SM) in immunocompromised patients are associated with a high mortality rate. Our report concerns a 40-year-old male newly diagnosed very severe aplastic anemia (vSAA) who in consequence of a mosquito bite was suffering from skin lesion and consecutive soft tissue phlegmon subsequent to the administration of antithymocyte globulin; a full-thickness autologous meshed skin graft successfully performed to cover skin ulcera after allogeneic stem cell transplantation (SCT). This unusual case illustrates the importance of appropriate diagnosis, anti-infective therapy and close interdisciplinary diagnostic algorithms to minimalize side effects and the selection of resistant strains and to improve patients' outcome. Read More

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http://dx.doi.org/10.1159/000495878DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381905PMC
January 2019

A Case of Streptozocin Monotherapy for Unresectable Duodenal Neuroendocrine Tumor G2.

Case Rep Oncol 2019 Jan-Apr;12(1):14-21. Epub 2019 Jan 4.

Saiseikai Kyoto Hospital, Kyoto, Japan.

Background: Duodenal neuroendocrine tumors (NET) are rare, and few reports have demonstrated the effectiveness of chemotherapy for duodenal NET, with not many other treatment options available. Here, we present a case of unresectable duodenal NET G2 that was effectively treated with streptozocin (STZ) monotherapy. We also perform a literature review. Read More

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http://dx.doi.org/10.1159/000496017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381881PMC
January 2019

Beyond KRAS: Practical Molecular Targets in Pancreatic Adenocarcinoma.

Case Rep Oncol 2019 Jan-Apr;12(1):7-13. Epub 2019 Jan 4.

Sharett Institute of Oncology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.

Pancreatic adenocarcinoma (PDAC) has a grim prognosis. Molecular and genomic analyses revealed that the striking majority of these tumors are driven by KRAS mutation, currently not amenable to targeted therapy. However, other driver mutations were found in a small fraction of patients. Read More

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http://dx.doi.org/10.1159/000496018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381925PMC
January 2019
2 Reads

Treatment of Chemotherapy-Induced Thrombotic Microangiopathy with Eculizumab in a Patient with Metastatic Breast Cancer.

Case Rep Oncol 2019 Jan-Apr;12(1):1-6. Epub 2019 Jan 3.

Dialysis Center Ludwigsburg, Ludwigsburg, Germany.

The unexpected occurrence of thrombotic microangiopathy (TMA), characterised by microangiopathic haemolytic anaemia and thrombocytopenia, in a patient with cancer requires urgent diagnosis and appropriate management. TMA in patients with metastatic cancer can be a manifestation of the malignancy itself or a therapeutic complication. Distinguishing the cause of TMA is complicated but clinically important to initiate appropriate treatment of metastatic cancer and avoid potential drug toxicity. Read More

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http://dx.doi.org/10.1159/000495031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381888PMC
January 2019
1 Read

Case Report: Oxaliplatin-Induced Immune-Mediated Thrombocytopenia.

Case Rep Oncol 2018 Sep-Dec;11(3):880-882. Epub 2018 Dec 20.

Division of Hematology, Department of Medicine, Keck School of Medicine of USC, Los Angeles, California, USA.

Thrombocytopenia is a frequent complication of cancer may be due to a variety of causes including malignancy itself, acute disease processes, or cancer therapy. Systemic cancer therapy is the most common cause of thrombocytopenia in cancer patients observed nearly two-thirds of patients with solid tumors. Thrombocytopenia with traditional chemotherapy agents is most frequently the result of megakaryocyte cytotoxicity. Read More

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https://www.karger.com/Article/FullText/495032
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http://dx.doi.org/10.1159/000495032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341312PMC
December 2018
9 Reads

Septic Shock Predisposed by an Underlying Chronic Neutrophilic Leukemia with an Atypical Presentation; A Case Report.

Case Rep Oncol 2018 Sep-Dec;11(3):871-879. Epub 2018 Dec 20.

Department of Hematology & Oncology, University of Texas Medical Branch, Galveston, Texas, USA.

Background: Chronic neutrophilic leukemia (CNL) is an extremely rare myeloproliferative neoplasm (MPN). Due to the difficulty in its diagnosis, the diagnostic criterion was just recently revised in 2016. CNL is defined as: A clonal disorder with sustained primary neutrophilia, with normal neutrophil maturation, that does not meet other MPN criteria, as well as no identifiable mutations of the PDGFRA, PDGFRB or FGFR1 or PCM1-JAK2 genes, and, either, the presence of a CSF3R mutation, or if absent, the presence of sustained neutrophilia (> 3 months), splenomegaly and no other identifiable cause of reactive neutrophilia including the absence of a plasma cell neoplasm, or, if present, demonstration of myeloid cell clonality by cytogenetics. Read More

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http://dx.doi.org/10.1159/000495458DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341362PMC
December 2018
5 Reads

Rare Case of Intracardiac Renal Cell Carcinoma Metastasis with Response to Nivolumab: Case Report and Literature Review.

Case Rep Oncol 2018 Sep-Dec;11(3):861-870. Epub 2018 Dec 20.

Department of Oncology, Royal Marsden Hospital, London, United Kingdom.

Intracardiac metastases in the absence of inferior vena cava involvement is a rare occurrence in patients with metastatic renal cell carcinoma (mRCC). There is limited evidence regarding the efficacy and safety of standard treatment modalities for mRCC patients with intracardiac metastases. Presence of intracardiac metastases is known to indicate poor prognosis and may potentially increase risk of treatment-related complications. Read More

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http://dx.doi.org/10.1159/000495459DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341359PMC
December 2018

Dual HER2 Suppression with Lapatinib plus Trastuzumab for Metastatic Inflammatory Breast Cancer: A Case Report of Prolonged Stable Disease.

Case Rep Oncol 2018 Sep-Dec;11(3):855-860. Epub 2018 Dec 19.

Arizona Oncology, US Oncology Network, Sedona, Arizona, USA.

Background: Continuous therapy targeting human epidermal growth factor receptor 2 (HER2) is recommended until disease progression for patients with HER2-overexpressing (HER2+) metastatic breast cancer. Prolonged stable disease has been observed with such maintenance therapy using trastuzumab, but the frequency of these cases remains low. Whether combined maintenance therapy with two different HER2-targeted agents could improve the rates of durable progression-free survival compared with trastuzumab alone is under investigation. Read More

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http://dx.doi.org/10.1159/000494264DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341317PMC
December 2018
1 Read

CD30-Positive Angioinvasive Lymphomatoid Papulosis (Type E) Developing from Parapsoriasis en Plaque.

Case Rep Oncol 2018 Sep-Dec;11(3):850-854. Epub 2018 Dec 13.

Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai, Japan.

Angioinvasive lymphomatoid papulosis (LyP) type E is a rare variant characterized by angiocentric and angiodestructive features with CD30+ CD8+ lymphocyte infiltration. In rare cases, LyP type E is concomitant with mycosis fungoides, but there is no English report that describe LyP type E developing from parapsoriasis en plaque. In this report, we described a case of angioinvasive LyP (type E) developing from parapsoriasis en plaque, in which we employed immunohistochemical staining for the investigation of its pathomechanisms. Read More

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http://dx.doi.org/10.1159/000495689DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341360PMC
December 2018
2 Reads

Immunocytochemistry Test of Protein BRAF Expression for Diagnosis of Well Differentiated Thyroid Carcinoma.

Case Rep Oncol 2018 Sep-Dec;11(3):843-849. Epub 2018 Dec 13.

Surgical Oncology Division, Department of Surgery, Faculty of Medicine, Udayana University, Sanglah General Hospital, Denpasar, Indonesia.

Background: Thyroid carcinoma generally has a good prognosis. The main focus of current research on thyroid carcinoma is to increase the accuracy of preoperative diagnosis of thyroid nodules. When the result of fine needle aspiration biopsy (FNAB) is indeterminate, clinicians often have doubts in determining the surgical management. Read More

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http://dx.doi.org/10.1159/000495029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341353PMC
December 2018
2 Reads

Trastuzumab-Based Combination Chemotherapy in Patients with Human Epidermal Growth Factor Receptor-2-Positive Metastatic Carcinoma ex Pleomorphic Adenoma.

Case Rep Oncol 2018 Sep-Dec;11(3):835-841. Epub 2018 Dec 11.

Department of Medical Oncology, Sapporo Medical University, Sapporo, Japan.

Background: Carcinoma ex pleomorphic adenoma (CXPA) is a rare histologic subtype of lacrimal gland and submandibular gland cancer. Currently, there is no standard treatment for metastatic CXPA, although some case reports have explored the role of targeted agents in chemotherapy. A few histopathologic analyses have shown that some of these tumors overexpress human epidermal growth factor receptor-2 (HER2), suggesting a potential role for HER2-based therapy. Read More

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http://dx.doi.org/10.1159/000495344DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341428PMC
December 2018
10 Reads

Invasive Pulmonary Adenocarcinoma with Lepidic Growth Pattern in a Pregnant Patient.

Case Rep Oncol 2018 Sep-Dec;11(3):822-834. Epub 2018 Dec 11.

University of Groningen, University Medical Center Groningen, Department of Neurology, Groningen, The Netherlands.

Among the differential diagnoses that should be considered in acute respiratory failure (ARF) are infectious processes, autoimmune diseases, interstitial pulmonary fibrosis, and pulmonary neoplasia. Timely diagnosis of lung neoplasia is complicated in the early stages. An opportune diagnosis, as well as the specific treatment, decrease mortality. Read More

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http://dx.doi.org/10.1159/000495460DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341323PMC
December 2018
14 Reads

Mantle Cell Lymphoma Case Report.

Case Rep Oncol 2018 Sep-Dec;11(3):814-821. Epub 2018 Dec 4.

Federal State Autonomous Educational Institution of Higher Education, I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University), Moscow, Russian Federation.

Introduction: Due to the beginning of the use of immunophenotypic and cytogenetic techniques, new nosological forms of lymphoproliferative diseases have appeared over the past few decades. According to the WHO classification (2008), today there are more than 50 known lymphoproliferative diseases.

Case Presentation: We present the case of a 51-year-old man with lymphoproliferative syndrome. Read More

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http://dx.doi.org/10.1159/000492665DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323362PMC
December 2018
3 Reads

Central Nervous System Peripheral T Cell Lymphoma Manifesting as Lymphomatosis Cerebri That Was Misdiagnosed as Neuro-Behçet's Disease: A Case Report.

Case Rep Oncol 2018 Sep-Dec;11(3):806-813. Epub 2018 Nov 29.

Division of Hematology, Department of Internal Medicine, Faculty of Medicine, Kagawa University, Kagawa, Japan.

Background: Lymphomatosis cerebri (LC) is a unique form of primary central nerves lymphoma (PCNSL), which presents as diffuse infiltration of lymphoma cells characteristically in the white matter rather than tumor formation. However, the involvement of central nervous system (CNS) is unclear because of the lack of contrast enhancement.

Case Presentation: We treated a 53-year-old woman with LC and brain lesions resembling neuro-Behcet's disease. Read More

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http://dx.doi.org/10.1159/000495033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323408PMC
November 2018
14 Reads

Two Cases of Long-Term Control of Metastatic Colorectal Cancer via FTD/TPI plus Bevacizumab in Elderly Patients.

Case Rep Oncol 2018 Sep-Dec;11(3):800-805. Epub 2018 Nov 29.

Department of Surgical Oncology, Osaka City University Graduate School of Medicine, Osaka, Japan.

With advances in new cytotoxic drugs and molecular-targeted drugs, the prognosis of patients with metastatic colorectal cancer (mCRC) has improved. However, physicians often hesitate to administer intensive standard regimens to elderly patients with mCRC. Recently, first-line regimens that are effective in and well-tolerated by patients who are not eligible for intensive chemotherapy have been established. Read More

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http://dx.doi.org/10.1159/000493849DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323394PMC
November 2018
1 Read

Co-Occurrence of Myeloid Sarcoma of the Lymph Node and Acute Monocytic Myeloid Leukemia: A Case Report and Literature Review.

Case Rep Oncol 2018 Sep-Dec;11(3):791-799. Epub 2018 Nov 29.

Division of Hematology and Oncology, Bronx Care Health System, Affiliated with Icahn School of Medicine at Mount Sinai, Bronx, New York, USA.

Background: Acute myeloid leukemia (AML) is the most common leukemia in adults. According to the French-American-British (FAB) system, monocytic leukemia is classified as M5. Myeloid sarcoma further occurs in 3-5% of AML. Read More

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http://dx.doi.org/10.1159/000494830DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323399PMC
November 2018
3 Reads

Gastrointestinal Perforation after Rituximab Therapy in Mantle Cell Lymphoma: A Case Report.

Case Rep Oncol 2018 Sep-Dec;11(3):784-790. Epub 2018 Nov 29.

Department of Hematology/Oncology, Sinai Hospital, Baltimore, Maryland, USA.

Mantle cell lymphoma (MCL) is a rare form of non-Hodgkin lymphoma (NHL), responsible for 2.8% of all NHL cases within the United States. The majority of patients with MCL present with advanced disease, 10-20% of which have extra-nodal involvement at diagnosis. Read More

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http://dx.doi.org/10.1159/000494828DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323410PMC
November 2018
2 Reads

Success of Crizotinib Combined with Whole-Brain Radiotherapy for Brain Metastases in a Patient with Anaplastic Lymphoma Kinase Rearrangement-Positive Non-Small-Cell Lung Cancer.

Case Rep Oncol 2018 Sep-Dec;11(3):777-783. Epub 2018 Nov 29.

Department of Oncology, Pharmaceutical Care and Sciences, Okayama University, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.

Although crizotinib shows marked antitumor activity in anaplastic lymphoma kinase (ALK) rearrangement-positive non-small-cell lung cancer (NSCLC) patients, all treated patients ultimately develop resistance to this drug. Isolated central nervous system failure without progression at extracranial sites is a common progression pattern in ALK rearrangement-positive NSCLC patients treated with crizotinib. Here, we report the success of crizotinib combined with whole-brain radiotherapy in an ALK rearrangement-positive NSCLC patient who developed leptomeningeal carcinomatosis and progression of multiple brain metastases. Read More

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https://www.karger.com/Article/FullText/492150
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http://dx.doi.org/10.1159/000492150DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323405PMC
November 2018
12 Reads

Treatment of Head and Neck Cancer with Photodynamic Therapy with Redaporfin: A Clinical Case Report.

Case Rep Oncol 2018 Sep-Dec;11(3):769-776. Epub 2018 Nov 27.

University Hospital of São João, Porto, Portugal.

Advanced head and neck squamous cell carcinoma, after locoregional treatment and multiple lines of systemic therapies, represents a great challenge to overcome acquired resistance. The present clinical case illustrates a successful treatment option and is the first to describe the use of photodynamic therapy (PDT) with Redaporfin, followed by immune checkpoint inhibition with an anti-PD1 antibody. This patient presented an extensive tumor in the mouth pavement progressing after surgery, radiotherapy, and multiple lines of systemic treatment. Read More

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https://www.karger.com/Article/FullText/493423
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http://dx.doi.org/10.1159/000493423DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323365PMC
November 2018
7 Reads

Application and Benefits of Web-Mediated Symptom Reporting for Patients Undergoing Immunotherapy: A Clinical Example.

Case Rep Oncol 2018 Sep-Dec;11(3):763-768. Epub 2018 Nov 27.

Normandie Université - CORIA, Campus Universitaire du Madrillet, Saint-Etienne du Rouvray, France.

Two randomized studies of symptom monitoring during chemotherapy or during second line treatment and follow-up via web-based patient-reported outcomes (PROs) was previously demonstrated to lengthen survival. We are presenting here a patient with advanced and recurrent lung cancer who was followed for 4 years by PROs for relapse and adverse events detection. We report how the web-mediated follow-up helped to detect dangerous pulmonary embolism, relapse and pseudo-progression to immunotherapy by self-reported symptom tracking and specific algorithms triggering notifications to medical team, allowing early management of events. Read More

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http://dx.doi.org/10.1159/000494829DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323363PMC
November 2018
2 Reads

Advanced Renal Cell Cancer and Low-Dose Palliative Radiation Treatment: A Case of a Substantial and Sustained Treatment Response.

Case Rep Oncol 2018 Sep-Dec;11(3):756-762. Epub 2018 Nov 27.

Northern Sydney Cancer Centre, Royal North Shore Hospital, Sydney, New South Wales, Australia.

Clear cell carcinoma is the most common form of renal cell carcinoma (RCC). Metastatic RCC is poorly responsive to treatment and has a bleak prognosis. Newer systemic agents have improved outcomes. Read More

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http://dx.doi.org/10.1159/000493913DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323401PMC
November 2018
2 Reads

Severe Photo Toxicity Recalled by Docetaxel.

Case Rep Oncol 2018 Sep-Dec;11(3):751-755. Epub 2018 Nov 12.

Capio S: t Görans Hospital, Department of Clinical Oncology, Stockholm, Sweden.

Photo-recall phenomenon is a rarely recognized adverse event of chemotherapeutic agents. The physiopathology of this entity is unclear. We have reported a 56-year old breast cancer patient with severe photo toxicity recalled 5 months after the initial sunburn by one course of adjuvant docetaxel treatment. Read More

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http://dx.doi.org/10.1159/000494208DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276744PMC
November 2018
20 Reads

Esophageal Adenocarcinoma with Extensive Metastasis to Unexpected Sites: A Case Report.

Case Rep Oncol 2018 Sep-Dec;11(3):742-750. Epub 2018 Nov 12.

Hematology/Oncology, University of Texas Medical Branch, Galveston, Texas, USA.

Background: Esophageal cancer (EC) with unexpected metastasis (UM) to unusual sites have been increasingly reported. EC with metastasis in general has a very high mortality and morbidity rate, and those with UM to unusual sites present another specific field that needs to be further studied in order to understand and manage the presentation. An extensive systematic review was recently completed regarding this field which identified characteristics and findings concerning patients with EC with UM sites. Read More

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https://www.karger.com/Article/FullText/494263
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http://dx.doi.org/10.1159/000494263DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276759PMC
November 2018
21 Reads

Thrombotic Microangiopathy with Severe Proteinuria Induced by Lenvatinib for Radioactive Iodine-Refractory Papillary Thyroid Carcinoma.

Case Rep Oncol 2018 Sep-Dec;11(3):735-741. Epub 2018 Nov 12.

Division of Medical Oncology/Hematology, Department of Medicine, Kobe University Graduate School of Medicine, Kobe, Japan.

Standard therapy for radioactive iodine (RAI)-refractory differentiated thyroid cancer (DTC) is multi-targeted kinase inhibitors (m-TKIs), represented by sorafenib and lenvatinib. One of the main target molecules of m-TKIs is vascular endothelial growth factor receptor (VEGF-R). m-TKIs are known to cause adverse reactions such as hypertension and proteinuria as a class effect. Read More

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http://dx.doi.org/10.1159/000494080DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276762PMC
November 2018
3 Reads

Cutaneous Ewing Sarcoma and Ewing Sarcoma of the Bone: Distinct Diseases.

Case Rep Oncol 2018 Sep-Dec;11(3):729-734. Epub 2018 Nov 12.

Kaiser Permanente, Los Angeles, California, USA.

Ewing sarcoma is an aggressive mesenchymal malignancy. It is the second most common bone tumor among children and adolescents and less commonly presents as a soft tissue or primary skin lesion. Cutaneous Ewing sarcoma has only been reported in case reports and case series. Read More

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http://dx.doi.org/10.1159/000492667DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276761PMC
November 2018
3 Reads

Radiotherapy in Patients with Mycosis Fungoides and Central Nervous System Involvement.

Case Rep Oncol 2018 Sep-Dec;11(3):721-728. Epub 2018 Nov 12.

Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

Background: Involvement of the central nervous system (CNS) by mycosis fungoides (MF) is rare; however, it portends a poor prognosis. While aggressive multimodality therapy may improve outcomes, the role of radiation therapy (RT) is not well defined.

Objectives: We sought to explore the efficacy of RT in the management of CNS involvement by MF. Read More

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http://dx.doi.org/10.1159/000494081DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276745PMC
November 2018
4 Reads

Factors Affecting Therapeutic Effects in 17 Patients with Advanced Hepatocellular Carcinoma Who Were Treated with Sorafenib for More than 12 Months.

Case Rep Oncol 2018 Sep-Dec;11(3):711-720. Epub 2018 Nov 1.

Department of Hepato-Biliary and Pancreatic Oncology, Osaka International Cancer Institute, Osaka, Japan.

Background And Objective: Sorafenib is recommended for treating advanced hepatocellular carcinoma. However, it is frequently discontinued because of adverse events, which greatly affects its therapeutic effects. Furthermore, because patients treated with sorafenib for a long period can presumably tolerate adverse events, this study aimed to identify their characteristics and analyze factors affecting the therapeutic effects of the drug. Read More

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http://dx.doi.org/10.1159/000493853DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6243964PMC
November 2018
1 Read

A Case of Multiple Myeloma Presenting as Meningitis with Fungemia.

Case Rep Oncol 2018 Sep-Dec;11(3):705-710. Epub 2018 Nov 1.

Kingsbrook Jewish Medical Center, Department of Medicine and New York Presbyterian - Brooklyn Methodist Hospital, Brooklyn, New York, USA.

Multiple myeloma (MM), a plasma cell neoplasm, has a typical presenting pattern consisting of bone pain, renal failure, anemia, and/or hypercalcemia. Even though MM is a cancer that impairs the immune system, rarely is a systemic infection the first sign of disease. In this case report, our patient presented with altered mental status due to meningitis and was later diagnosed with MM. Read More

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http://dx.doi.org/10.1159/000493852DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6243956PMC
November 2018
5 Reads

Acute Liver Failure with Diffuse Liver Metastasis from Breast Cancer, Not Detected by Computed Tomography: 2 Case Reports.

Case Rep Oncol 2018 Sep-Dec;11(3):699-704. Epub 2018 Oct 31.

Department of Medical Oncology, Kobe City Hospital Organization Kobe City Medical Center General Hospital, Chuo-ku, Japan.

Diffuse liver metastasis is a rare pattern of liver metastasis that is associated with hepatic failure and poor prognosis. We experienced 2 cases of acute liver failure due to diffuse metastasis that could not be detected using computed tomography. In , it was difficult to differentiate diffuse metastasis from alcoholic hepatitis. Read More

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http://dx.doi.org/10.1159/000493848DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6243952PMC
October 2018
1 Read

The Smallest Reported Malignant Struma Ovarii: A Case Report.

Case Rep Oncol 2018 Sep-Dec;11(3):693-698. Epub 2018 Oct 31.

Department of Gynecology and Obstetrics, Tagawa Municipal Hospital, Fukuoka, Japan.

Introduction: Malignant struma ovarii is a rare neoplasm. It is usually asymptomatic and not commonly diagnosed preoperatively. In addition, there is currently no established diagnostic and therapeutic approach for malignant struma ovarii. Read More

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https://www.karger.com/Article/FullText/493254
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http://dx.doi.org/10.1159/000493254DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6244102PMC
October 2018
14 Reads

Successful Use of Pembrolizumab to Treat Refractory Thymic Carcinoma with High PD-L1 Expression.

Case Rep Oncol 2018 Sep-Dec;11(3):688-692. Epub 2018 Oct 31.

Department of Respiratory Medicine, Toho University Graduate School of Medicine, Tokyo, Japan.

Thymic carcinoma is a relatively rare and aggressive thymic epithelial tumor. Herein, we report successful treatment of thymic carcinoma with pembrolizumab. A 68-year-old woman was admitted to our hospital for evaluation of chest pain. Read More

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http://dx.doi.org/10.1159/000493187DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6243955PMC
October 2018
17 Reads

Hydrogen Sulfide-Synthesizing Enzymes Are Altered in a Case of Oral Cavity Mucoepidermoid Carcinoma.

Case Rep Oncol 2018 Sep-Dec;11(3):682-687. Epub 2018 Oct 31.

Department of Pathology, LSU Health Shreveport, Shreveport, Louisiana, USA.

Mucoepidermoid carcinoma (MEC) is the most common malignant epithelial neoplasm of the salivary glands. MECs of the mouth floor are rare, with only a few cases reported. Here we report a MEC of the mouth floor in a 55-year-old woman. Read More

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http://dx.doi.org/10.1159/000493008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6244100PMC
October 2018
4 Reads

Poorly Differentiated Small-Cell-Type Neuroendocrine Carcinoma of the Prostate: A Case Report and Literature Review.

Case Rep Oncol 2018 Sep-Dec;11(3):676-681. Epub 2018 Oct 31.

Department of Medicine, Bronx Lebanon Hospital Center, Bronx, New York, USA.

Neuroendocrine cells are widespread throughout the body and can give rise of neuroendocrine tumors due to abnormal growth of the chromaffin cells. Neuroendocrine tumors divide into many subtypes based on tumor grade (Ki-67 index and mitotic count) and differentiation. These tumors can be further divided into secretory and nonsecretory types based on the production of peptide hormone by tumor cells. Read More

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http://dx.doi.org/10.1159/000493255DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6243899PMC
October 2018
3 Reads

Keratoacanthoma Centrifugum Marginatum with Spontaneous Regression and Its Possible Differential Diagnosis.

Case Rep Oncol 2018 Sep-Dec;11(3):671-675. Epub 2018 Oct 24.

Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai, Japan.

Keratoacanthoma centrifugum marignatum (KCM) is a rare variant of keratoacanthoma, which is characterized by the dense infiltration of inflammatory cells throughout the dermis, especially around the keratinocytic islands. Therefore, it is sometimes difficult to differentiate between KCM and cutaneous T-cell lymphomas. In this report, we describe a case of KCM with spontaneous regression that showed dense infiltration of CD3+CD8+ T cells. Read More

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http://dx.doi.org/10.1159/000493089DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6244034PMC
October 2018
4 Reads

Large Cell Neuroendocrine Carcinoma of the Cervix with Sequential Metastasis to Different Sites: A Case Report.

Case Rep Oncol 2018 Sep-Dec;11(3):665-670. Epub 2018 Oct 23.

Department of Obstetrics and Gynecology, Inje University Haeundae Paik Hospital, Busan, Republic of Korea.

Neuroendocrine carcinoma of the cervix is rare, and prognosis is very poor. Because of its rarity, effective treatment of neuroendocrine carcinoma of the cervix has not been established. It has distinct patterns of metastasis, but can be successfully treated with radical surgery and platinum-based chemotherapy. Read More

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http://dx.doi.org/10.1159/000493912DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6243902PMC
October 2018
2 Reads

Breast Cancer Metastasis in the Skin with Hyperkeratotic Pigmentation Caused by Melanocyte Colonization.

Case Rep Oncol 2018 Sep-Dec;11(3):660-664. Epub 2018 Oct 23.

Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai, Japan.

Pigmented breast cancer in the skin caused by nonneoplastic melanocytes of epidermal origin is a rare condition of metastasis from breast cancer, but the pathogenesis of this phenomenon is almost unknown. In this report, we describe a case of breast cancer metastasis in the skin with prominent hyperkeratotic pigmentation caused by nonneoplastic melanocyte colonization. Immunohistochemical staining revealed that the metastatic tumor cells produced IL-23, which is reported not only to induce IL-17 but also to inhibit cell apoptosis in breast cancer cells, which affects tumor progression. Read More

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http://dx.doi.org/10.1159/000493186DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6244098PMC
October 2018
14 Reads

Capecitabine-Associated Terminal Ileitis.

Case Rep Oncol 2018 Sep-Dec;11(3):654-659. Epub 2018 Oct 22.

Department of Internal Medicine, Catharina Hospital, Eindhoven, the Netherlands.

Capecitabine is an oral fluoropyrimidine used as adjuvant and palliative chemotherapy in patients with colorectal cancer. Diarrhea is a well-known side effect of capecitabine and 5-fluorouracil agents. We present a case with terminal ileitis as a rare adverse event of capecitabine treatment. Read More

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http://dx.doi.org/10.1159/000492781DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6243901PMC
October 2018
14 Reads

Thromboembolic Events Related to Treatment with Checkpoint Inhibitors: Report of Two Cases.

Case Rep Oncol 2018 Sep-Dec;11(3):648-653. Epub 2018 Oct 22.

Americas Oncologia, Department of Oncology, Hospital Samaritano, São Paulo, Brazil.

Despite the significant clinical benefits, checkpoint inhibition is associated with a unique spectrum of immune-related adverse events. It is sometimes difficult to distinguish some rare adverse effects from a cancer progression; thus, such effects should be reported in clinical trials to be diagnosed by physicians. Only a few cases of arterial embolic events have been described in studies related to patients treated by immunotherapy. Read More

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http://dx.doi.org/10.1159/000492463DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6243904PMC
October 2018
1 Read

Primary Gastrointestinal Kaposi's Sarcoma in a Patient with Human Immunodeficiency Virus.

Case Rep Oncol 2018 Sep-Dec;11(3):638-647. Epub 2018 Oct 22.

Internship in Medicine, Fundacion Universitaria Sanitas, Bogotá, Colombia.

Gastrointestinal bleeding in HIV patients secondary to coinfection by HHV8 and development of Kaposi's sarcoma (KS) is a rare complication even if no skin lesions are detected on physical examination. This article indicates which patients might develop this type of clinical sign and also tries to recall that absence of skin lesions never rules out the presence of KS, especially if gastrointestinal involvement is documented. Gastrointestinal bleeding in terms of hematemesis has rarely been reported in the literature. Read More

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http://dx.doi.org/10.1159/000492715DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6244015PMC
October 2018
16 Reads

Sarcomatoid Variant of Bladder Carcinoma: A Case Report.

Case Rep Oncol 2018 Sep-Dec;11(3):633-637. Epub 2018 Sep 13.

Departments of Urology and Renal Transplantation, Yokohama City University Medical Center, Yokohama, Japan.

A 59-year-old man was referred to our hospital complaining of asymptomatic gross hematuria. Cystoscopy revealed a papillary tumor 8 cm in diameter filling the bladder. The patient underwent transurethral resection of the bladder tumor. Read More

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https://www.karger.com/Article/FullText/492779
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http://dx.doi.org/10.1159/000492779DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6180258PMC
September 2018
18 Reads

Rechallenge with First-Line Platinum Chemotherapy for Sensitive-Relapsed Small-Cell Lung Cancer.

Case Rep Oncol 2018 Sep-Dec;11(3):622-632. Epub 2018 Sep 7.

Department of Respiratory Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.

Background: Sensitive-relapsed small-cell lung cancer (SCLC) is thought to be sensitive to chemotherapy; therefore, second-line chemotherapy is recommended. Although platinum rechallenge is performed in the second-line chemotherapy for sensitive-relapsed SCLC, it remains unclear whether such a strategy is effective.

Methods: We retrospectively analyzed the outcome of rechallenge chemotherapy for sensitive-relapsed SCLC. Read More

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https://www.karger.com/Article/FullText/492780
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http://dx.doi.org/10.1159/000492780DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6180263PMC
September 2018
18 Reads

Nivolumab-Induced Impressive Response of Refractory Pulmonary Sarcomatoid Carcinoma with Brain Metastasis.

Case Rep Oncol 2018 Sep-Dec;11(3):615-621. Epub 2018 Sep 7.

Department of Oncology, University of Modena and Reggio Emilia - Policlinico of Modena, Modena, Italy.

Background: Pulmonary sarcomatoid carcinoma is a rare, poorly differentiated, and highly aggressive type of non-small cell lung cancer. High tumor mutational burden and PD-L1 overexpression make it an excellent candidate for immunotherapy.

Objectives And Method: We presented the case of a patient who underwent left inferior lobectomy with concurrent right paravertebral muscular metastasectomy for an infiltrative neoplastic mass, whose final diagnosis was consistent with stage IV pulmonary sarcomatoid carcinoma. Read More

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https://www.karger.com/Article/FullText/492666
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http://dx.doi.org/10.1159/000492666DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6180262PMC
September 2018
5 Reads

Bowen's Disease of the Nipple.

Case Rep Oncol 2018 Sep-Dec;11(3):609-614. Epub 2018 Sep 7.

Department of Pathology, Ibaraki Prefectural Central Hospital and Cancer Center, Kasama, Japan.

Bowen's disease is a type of intraepidermal squamous cell carcinoma that commonly develops in areas of the skin exposed to sunlight, such as the scalp, trunk, and limbs. Although development of Bowen's disease in other sites, such as the nipple, is extremely rare, we herein report our experience with one such case. A 76-year-old female presented to our hospital with complaints of right nipple pruritus. Read More

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http://dx.doi.org/10.1159/000492382DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6180276PMC
September 2018
2 Reads