1,137 results match your criteria Case reports in oncology[Journal]


Case Report: Oxaliplatin-Induced Immune-Mediated Thrombocytopenia.

Case Rep Oncol 2018 Sep-Dec;11(3):880-882. Epub 2018 Dec 20.

Division of Hematology, Department of Medicine, Keck School of Medicine of USC, Los Angeles, California, USA.

Thrombocytopenia is a frequent complication of cancer may be due to a variety of causes including malignancy itself, acute disease processes, or cancer therapy. Systemic cancer therapy is the most common cause of thrombocytopenia in cancer patients observed nearly two-thirds of patients with solid tumors. Thrombocytopenia with traditional chemotherapy agents is most frequently the result of megakaryocyte cytotoxicity. Read More

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https://www.karger.com/Article/FullText/495032
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http://dx.doi.org/10.1159/000495032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341312PMC
December 2018
4 Reads

Septic Shock Predisposed by an Underlying Chronic Neutrophilic Leukemia with an Atypical Presentation; A Case Report.

Case Rep Oncol 2018 Sep-Dec;11(3):871-879. Epub 2018 Dec 20.

Department of Hematology & Oncology, University of Texas Medical Branch, Galveston, Texas, USA.

Background: Chronic neutrophilic leukemia (CNL) is an extremely rare myeloproliferative neoplasm (MPN). Due to the difficulty in its diagnosis, the diagnostic criterion was just recently revised in 2016. CNL is defined as: A clonal disorder with sustained primary neutrophilia, with normal neutrophil maturation, that does not meet other MPN criteria, as well as no identifiable mutations of the PDGFRA, PDGFRB or FGFR1 or PCM1-JAK2 genes, and, either, the presence of a CSF3R mutation, or if absent, the presence of sustained neutrophilia (> 3 months), splenomegaly and no other identifiable cause of reactive neutrophilia including the absence of a plasma cell neoplasm, or, if present, demonstration of myeloid cell clonality by cytogenetics. Read More

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http://dx.doi.org/10.1159/000495458DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341362PMC
December 2018
2 Reads

Rare Case of Intracardiac Renal Cell Carcinoma Metastasis with Response to Nivolumab: Case Report and Literature Review.

Case Rep Oncol 2018 Sep-Dec;11(3):861-870. Epub 2018 Dec 20.

Department of Oncology, Royal Marsden Hospital, London, United Kingdom.

Intracardiac metastases in the absence of inferior vena cava involvement is a rare occurrence in patients with metastatic renal cell carcinoma (mRCC). There is limited evidence regarding the efficacy and safety of standard treatment modalities for mRCC patients with intracardiac metastases. Presence of intracardiac metastases is known to indicate poor prognosis and may potentially increase risk of treatment-related complications. Read More

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http://dx.doi.org/10.1159/000495459DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341359PMC
December 2018

Dual HER2 Suppression with Lapatinib plus Trastuzumab for Metastatic Inflammatory Breast Cancer: A Case Report of Prolonged Stable Disease.

Case Rep Oncol 2018 Sep-Dec;11(3):855-860. Epub 2018 Dec 19.

Arizona Oncology, US Oncology Network, Sedona, Arizona, USA.

Background: Continuous therapy targeting human epidermal growth factor receptor 2 (HER2) is recommended until disease progression for patients with HER2-overexpressing (HER2+) metastatic breast cancer. Prolonged stable disease has been observed with such maintenance therapy using trastuzumab, but the frequency of these cases remains low. Whether combined maintenance therapy with two different HER2-targeted agents could improve the rates of durable progression-free survival compared with trastuzumab alone is under investigation. Read More

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http://dx.doi.org/10.1159/000494264DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341317PMC
December 2018
1 Read

CD30-Positive Angioinvasive Lymphomatoid Papulosis (Type E) Developing from Parapsoriasis en Plaque.

Case Rep Oncol 2018 Sep-Dec;11(3):850-854. Epub 2018 Dec 13.

Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai, Japan.

Angioinvasive lymphomatoid papulosis (LyP) type E is a rare variant characterized by angiocentric and angiodestructive features with CD30+ CD8+ lymphocyte infiltration. In rare cases, LyP type E is concomitant with mycosis fungoides, but there is no English report that describe LyP type E developing from parapsoriasis en plaque. In this report, we described a case of angioinvasive LyP (type E) developing from parapsoriasis en plaque, in which we employed immunohistochemical staining for the investigation of its pathomechanisms. Read More

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http://dx.doi.org/10.1159/000495689DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341360PMC
December 2018
1 Read

Immunocytochemistry Test of Protein BRAF Expression for Diagnosis of Well Differentiated Thyroid Carcinoma.

Case Rep Oncol 2018 Sep-Dec;11(3):843-849. Epub 2018 Dec 13.

Surgical Oncology Division, Department of Surgery, Faculty of Medicine, Udayana University, Sanglah General Hospital, Denpasar, Indonesia.

Background: Thyroid carcinoma generally has a good prognosis. The main focus of current research on thyroid carcinoma is to increase the accuracy of preoperative diagnosis of thyroid nodules. When the result of fine needle aspiration biopsy (FNAB) is indeterminate, clinicians often have doubts in determining the surgical management. Read More

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http://dx.doi.org/10.1159/000495029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341353PMC
December 2018

Trastuzumab-Based Combination Chemotherapy in Patients with Human Epidermal Growth Factor Receptor-2-Positive Metastatic Carcinoma ex Pleomorphic Adenoma.

Case Rep Oncol 2018 Sep-Dec;11(3):835-841. Epub 2018 Dec 11.

Department of Medical Oncology, Sapporo Medical University, Sapporo, Japan.

Background: Carcinoma ex pleomorphic adenoma (CXPA) is a rare histologic subtype of lacrimal gland and submandibular gland cancer. Currently, there is no standard treatment for metastatic CXPA, although some case reports have explored the role of targeted agents in chemotherapy. A few histopathologic analyses have shown that some of these tumors overexpress human epidermal growth factor receptor-2 (HER2), suggesting a potential role for HER2-based therapy. Read More

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http://dx.doi.org/10.1159/000495344DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341428PMC
December 2018
2 Reads

Invasive Pulmonary Adenocarcinoma with Lepidic Growth Pattern in a Pregnant Patient.

Case Rep Oncol 2018 Sep-Dec;11(3):822-834. Epub 2018 Dec 11.

University of Groningen, University Medical Center Groningen, Department of Neurology, Groningen, The Netherlands.

Among the differential diagnoses that should be considered in acute respiratory failure (ARF) are infectious processes, autoimmune diseases, interstitial pulmonary fibrosis, and pulmonary neoplasia. Timely diagnosis of lung neoplasia is complicated in the early stages. An opportune diagnosis, as well as the specific treatment, decrease mortality. Read More

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http://dx.doi.org/10.1159/000495460DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341323PMC
December 2018
6 Reads

Mantle Cell Lymphoma Case Report.

Case Rep Oncol 2018 Sep-Dec;11(3):814-821. Epub 2018 Dec 4.

Federal State Autonomous Educational Institution of Higher Education, I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University), Moscow, Russian Federation.

Introduction: Due to the beginning of the use of immunophenotypic and cytogenetic techniques, new nosological forms of lymphoproliferative diseases have appeared over the past few decades. According to the WHO classification (2008), today there are more than 50 known lymphoproliferative diseases.

Case Presentation: We present the case of a 51-year-old man with lymphoproliferative syndrome. Read More

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http://dx.doi.org/10.1159/000492665DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323362PMC
December 2018
2 Reads

Central Nervous System Peripheral T Cell Lymphoma Manifesting as Lymphomatosis Cerebri That Was Misdiagnosed as Neuro-Behçet's Disease: A Case Report.

Case Rep Oncol 2018 Sep-Dec;11(3):806-813. Epub 2018 Nov 29.

Division of Hematology, Department of Internal Medicine, Faculty of Medicine, Kagawa University, Kagawa, Japan.

Background: Lymphomatosis cerebri (LC) is a unique form of primary central nerves lymphoma (PCNSL), which presents as diffuse infiltration of lymphoma cells characteristically in the white matter rather than tumor formation. However, the involvement of central nervous system (CNS) is unclear because of the lack of contrast enhancement.

Case Presentation: We treated a 53-year-old woman with LC and brain lesions resembling neuro-Behcet's disease. Read More

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http://dx.doi.org/10.1159/000495033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323408PMC
November 2018
5 Reads

Two Cases of Long-Term Control of Metastatic Colorectal Cancer via FTD/TPI plus Bevacizumab in Elderly Patients.

Case Rep Oncol 2018 Sep-Dec;11(3):800-805. Epub 2018 Nov 29.

Department of Surgical Oncology, Osaka City University Graduate School of Medicine, Osaka, Japan.

With advances in new cytotoxic drugs and molecular-targeted drugs, the prognosis of patients with metastatic colorectal cancer (mCRC) has improved. However, physicians often hesitate to administer intensive standard regimens to elderly patients with mCRC. Recently, first-line regimens that are effective in and well-tolerated by patients who are not eligible for intensive chemotherapy have been established. Read More

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http://dx.doi.org/10.1159/000493849DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323394PMC
November 2018
1 Read

Co-Occurrence of Myeloid Sarcoma of the Lymph Node and Acute Monocytic Myeloid Leukemia: A Case Report and Literature Review.

Case Rep Oncol 2018 Sep-Dec;11(3):791-799. Epub 2018 Nov 29.

Division of Hematology and Oncology, Bronx Care Health System, Affiliated with Icahn School of Medicine at Mount Sinai, Bronx, New York, USA.

Background: Acute myeloid leukemia (AML) is the most common leukemia in adults. According to the French-American-British (FAB) system, monocytic leukemia is classified as M5. Myeloid sarcoma further occurs in 3-5% of AML. Read More

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http://dx.doi.org/10.1159/000494830DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323399PMC
November 2018
2 Reads

Gastrointestinal Perforation after Rituximab Therapy in Mantle Cell Lymphoma: A Case Report.

Case Rep Oncol 2018 Sep-Dec;11(3):784-790. Epub 2018 Nov 29.

Department of Hematology/Oncology, Sinai Hospital, Baltimore, Maryland, USA.

Mantle cell lymphoma (MCL) is a rare form of non-Hodgkin lymphoma (NHL), responsible for 2.8% of all NHL cases within the United States. The majority of patients with MCL present with advanced disease, 10-20% of which have extra-nodal involvement at diagnosis. Read More

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http://dx.doi.org/10.1159/000494828DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323410PMC
November 2018
2 Reads

Success of Crizotinib Combined with Whole-Brain Radiotherapy for Brain Metastases in a Patient with Anaplastic Lymphoma Kinase Rearrangement-Positive Non-Small-Cell Lung Cancer.

Case Rep Oncol 2018 Sep-Dec;11(3):777-783. Epub 2018 Nov 29.

Department of Oncology, Pharmaceutical Care and Sciences, Okayama University, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.

Although crizotinib shows marked antitumor activity in anaplastic lymphoma kinase (ALK) rearrangement-positive non-small-cell lung cancer (NSCLC) patients, all treated patients ultimately develop resistance to this drug. Isolated central nervous system failure without progression at extracranial sites is a common progression pattern in ALK rearrangement-positive NSCLC patients treated with crizotinib. Here, we report the success of crizotinib combined with whole-brain radiotherapy in an ALK rearrangement-positive NSCLC patient who developed leptomeningeal carcinomatosis and progression of multiple brain metastases. Read More

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https://www.karger.com/Article/FullText/492150
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http://dx.doi.org/10.1159/000492150DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323405PMC
November 2018
6 Reads

Treatment of Head and Neck Cancer with Photodynamic Therapy with Redaporfin: A Clinical Case Report.

Case Rep Oncol 2018 Sep-Dec;11(3):769-776. Epub 2018 Nov 27.

University Hospital of São João, Porto, Portugal.

Advanced head and neck squamous cell carcinoma, after locoregional treatment and multiple lines of systemic therapies, represents a great challenge to overcome acquired resistance. The present clinical case illustrates a successful treatment option and is the first to describe the use of photodynamic therapy (PDT) with Redaporfin, followed by immune checkpoint inhibition with an anti-PD1 antibody. This patient presented an extensive tumor in the mouth pavement progressing after surgery, radiotherapy, and multiple lines of systemic treatment. Read More

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https://www.karger.com/Article/FullText/493423
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http://dx.doi.org/10.1159/000493423DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323365PMC
November 2018
5 Reads

Application and Benefits of Web-Mediated Symptom Reporting for Patients Undergoing Immunotherapy: A Clinical Example.

Case Rep Oncol 2018 Sep-Dec;11(3):763-768. Epub 2018 Nov 27.

Normandie Université - CORIA, Campus Universitaire du Madrillet, Saint-Etienne du Rouvray, France.

Two randomized studies of symptom monitoring during chemotherapy or during second line treatment and follow-up via web-based patient-reported outcomes (PROs) was previously demonstrated to lengthen survival. We are presenting here a patient with advanced and recurrent lung cancer who was followed for 4 years by PROs for relapse and adverse events detection. We report how the web-mediated follow-up helped to detect dangerous pulmonary embolism, relapse and pseudo-progression to immunotherapy by self-reported symptom tracking and specific algorithms triggering notifications to medical team, allowing early management of events. Read More

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http://dx.doi.org/10.1159/000494829DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323363PMC
November 2018
2 Reads

Advanced Renal Cell Cancer and Low-Dose Palliative Radiation Treatment: A Case of a Substantial and Sustained Treatment Response.

Case Rep Oncol 2018 Sep-Dec;11(3):756-762. Epub 2018 Nov 27.

Northern Sydney Cancer Centre, Royal North Shore Hospital, Sydney, New South Wales, Australia.

Clear cell carcinoma is the most common form of renal cell carcinoma (RCC). Metastatic RCC is poorly responsive to treatment and has a bleak prognosis. Newer systemic agents have improved outcomes. Read More

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http://dx.doi.org/10.1159/000493913DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323401PMC
November 2018
2 Reads

Severe Photo Toxicity Recalled by Docetaxel.

Case Rep Oncol 2018 Sep-Dec;11(3):751-755. Epub 2018 Nov 12.

Capio S: t Görans Hospital, Department of Clinical Oncology, Stockholm, Sweden.

Photo-recall phenomenon is a rarely recognized adverse event of chemotherapeutic agents. The physiopathology of this entity is unclear. We have reported a 56-year old breast cancer patient with severe photo toxicity recalled 5 months after the initial sunburn by one course of adjuvant docetaxel treatment. Read More

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http://dx.doi.org/10.1159/000494208DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276744PMC
November 2018
12 Reads

Esophageal Adenocarcinoma with Extensive Metastasis to Unexpected Sites: A Case Report.

Case Rep Oncol 2018 Sep-Dec;11(3):742-750. Epub 2018 Nov 12.

Hematology/Oncology, University of Texas Medical Branch, Galveston, Texas, USA.

Background: Esophageal cancer (EC) with unexpected metastasis (UM) to unusual sites have been increasingly reported. EC with metastasis in general has a very high mortality and morbidity rate, and those with UM to unusual sites present another specific field that needs to be further studied in order to understand and manage the presentation. An extensive systematic review was recently completed regarding this field which identified characteristics and findings concerning patients with EC with UM sites. Read More

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https://www.karger.com/Article/FullText/494263
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http://dx.doi.org/10.1159/000494263DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276759PMC
November 2018
15 Reads

Thrombotic Microangiopathy with Severe Proteinuria Induced by Lenvatinib for Radioactive Iodine-Refractory Papillary Thyroid Carcinoma.

Case Rep Oncol 2018 Sep-Dec;11(3):735-741. Epub 2018 Nov 12.

Division of Medical Oncology/Hematology, Department of Medicine, Kobe University Graduate School of Medicine, Kobe, Japan.

Standard therapy for radioactive iodine (RAI)-refractory differentiated thyroid cancer (DTC) is multi-targeted kinase inhibitors (m-TKIs), represented by sorafenib and lenvatinib. One of the main target molecules of m-TKIs is vascular endothelial growth factor receptor (VEGF-R). m-TKIs are known to cause adverse reactions such as hypertension and proteinuria as a class effect. Read More

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http://dx.doi.org/10.1159/000494080DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276762PMC
November 2018
2 Reads

Cutaneous Ewing Sarcoma and Ewing Sarcoma of the Bone: Distinct Diseases.

Case Rep Oncol 2018 Sep-Dec;11(3):729-734. Epub 2018 Nov 12.

Kaiser Permanente, Los Angeles, California, USA.

Ewing sarcoma is an aggressive mesenchymal malignancy. It is the second most common bone tumor among children and adolescents and less commonly presents as a soft tissue or primary skin lesion. Cutaneous Ewing sarcoma has only been reported in case reports and case series. Read More

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http://dx.doi.org/10.1159/000492667DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276761PMC
November 2018
3 Reads

Radiotherapy in Patients with Mycosis Fungoides and Central Nervous System Involvement.

Case Rep Oncol 2018 Sep-Dec;11(3):721-728. Epub 2018 Nov 12.

Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

Background: Involvement of the central nervous system (CNS) by mycosis fungoides (MF) is rare; however, it portends a poor prognosis. While aggressive multimodality therapy may improve outcomes, the role of radiation therapy (RT) is not well defined.

Objectives: We sought to explore the efficacy of RT in the management of CNS involvement by MF. Read More

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http://dx.doi.org/10.1159/000494081DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276745PMC
November 2018
3 Reads

Factors Affecting Therapeutic Effects in 17 Patients with Advanced Hepatocellular Carcinoma Who Were Treated with Sorafenib for More than 12 Months.

Case Rep Oncol 2018 Sep-Dec;11(3):711-720. Epub 2018 Nov 1.

Department of Hepato-Biliary and Pancreatic Oncology, Osaka International Cancer Institute, Osaka, Japan.

Background And Objective: Sorafenib is recommended for treating advanced hepatocellular carcinoma. However, it is frequently discontinued because of adverse events, which greatly affects its therapeutic effects. Furthermore, because patients treated with sorafenib for a long period can presumably tolerate adverse events, this study aimed to identify their characteristics and analyze factors affecting the therapeutic effects of the drug. Read More

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http://dx.doi.org/10.1159/000493853DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6243964PMC
November 2018
1 Read

A Case of Multiple Myeloma Presenting as Meningitis with Fungemia.

Case Rep Oncol 2018 Sep-Dec;11(3):705-710. Epub 2018 Nov 1.

Kingsbrook Jewish Medical Center, Department of Medicine and New York Presbyterian - Brooklyn Methodist Hospital, Brooklyn, New York, USA.

Multiple myeloma (MM), a plasma cell neoplasm, has a typical presenting pattern consisting of bone pain, renal failure, anemia, and/or hypercalcemia. Even though MM is a cancer that impairs the immune system, rarely is a systemic infection the first sign of disease. In this case report, our patient presented with altered mental status due to meningitis and was later diagnosed with MM. Read More

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http://dx.doi.org/10.1159/000493852DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6243956PMC
November 2018
4 Reads

Acute Liver Failure with Diffuse Liver Metastasis from Breast Cancer, Not Detected by Computed Tomography: 2 Case Reports.

Case Rep Oncol 2018 Sep-Dec;11(3):699-704. Epub 2018 Oct 31.

Department of Medical Oncology, Kobe City Hospital Organization Kobe City Medical Center General Hospital, Chuo-ku, Japan.

Diffuse liver metastasis is a rare pattern of liver metastasis that is associated with hepatic failure and poor prognosis. We experienced 2 cases of acute liver failure due to diffuse metastasis that could not be detected using computed tomography. In , it was difficult to differentiate diffuse metastasis from alcoholic hepatitis. Read More

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http://dx.doi.org/10.1159/000493848DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6243952PMC
October 2018
1 Read

The Smallest Reported Malignant Struma Ovarii: A Case Report.

Case Rep Oncol 2018 Sep-Dec;11(3):693-698. Epub 2018 Oct 31.

Department of Gynecology and Obstetrics, Tagawa Municipal Hospital, Fukuoka, Japan.

Introduction: Malignant struma ovarii is a rare neoplasm. It is usually asymptomatic and not commonly diagnosed preoperatively. In addition, there is currently no established diagnostic and therapeutic approach for malignant struma ovarii. Read More

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https://www.karger.com/Article/FullText/493254
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http://dx.doi.org/10.1159/000493254DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6244102PMC
October 2018
8 Reads

Successful Use of Pembrolizumab to Treat Refractory Thymic Carcinoma with High PD-L1 Expression.

Case Rep Oncol 2018 Sep-Dec;11(3):688-692. Epub 2018 Oct 31.

Department of Respiratory Medicine, Toho University Graduate School of Medicine, Tokyo, Japan.

Thymic carcinoma is a relatively rare and aggressive thymic epithelial tumor. Herein, we report successful treatment of thymic carcinoma with pembrolizumab. A 68-year-old woman was admitted to our hospital for evaluation of chest pain. Read More

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http://dx.doi.org/10.1159/000493187DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6243955PMC
October 2018
8 Reads

Hydrogen Sulfide-Synthesizing Enzymes Are Altered in a Case of Oral Cavity Mucoepidermoid Carcinoma.

Case Rep Oncol 2018 Sep-Dec;11(3):682-687. Epub 2018 Oct 31.

Department of Pathology, LSU Health Shreveport, Shreveport, Louisiana, USA.

Mucoepidermoid carcinoma (MEC) is the most common malignant epithelial neoplasm of the salivary glands. MECs of the mouth floor are rare, with only a few cases reported. Here we report a MEC of the mouth floor in a 55-year-old woman. Read More

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http://dx.doi.org/10.1159/000493008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6244100PMC
October 2018
3 Reads

Poorly Differentiated Small-Cell-Type Neuroendocrine Carcinoma of the Prostate: A Case Report and Literature Review.

Case Rep Oncol 2018 Sep-Dec;11(3):676-681. Epub 2018 Oct 31.

Department of Medicine, Bronx Lebanon Hospital Center, Bronx, New York, USA.

Neuroendocrine cells are widespread throughout the body and can give rise of neuroendocrine tumors due to abnormal growth of the chromaffin cells. Neuroendocrine tumors divide into many subtypes based on tumor grade (Ki-67 index and mitotic count) and differentiation. These tumors can be further divided into secretory and nonsecretory types based on the production of peptide hormone by tumor cells. Read More

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http://dx.doi.org/10.1159/000493255DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6243899PMC
October 2018
2 Reads

Keratoacanthoma Centrifugum Marginatum with Spontaneous Regression and Its Possible Differential Diagnosis.

Case Rep Oncol 2018 Sep-Dec;11(3):671-675. Epub 2018 Oct 24.

Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai, Japan.

Keratoacanthoma centrifugum marignatum (KCM) is a rare variant of keratoacanthoma, which is characterized by the dense infiltration of inflammatory cells throughout the dermis, especially around the keratinocytic islands. Therefore, it is sometimes difficult to differentiate between KCM and cutaneous T-cell lymphomas. In this report, we describe a case of KCM with spontaneous regression that showed dense infiltration of CD3+CD8+ T cells. Read More

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http://dx.doi.org/10.1159/000493089DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6244034PMC
October 2018
4 Reads

Large Cell Neuroendocrine Carcinoma of the Cervix with Sequential Metastasis to Different Sites: A Case Report.

Case Rep Oncol 2018 Sep-Dec;11(3):665-670. Epub 2018 Oct 23.

Department of Obstetrics and Gynecology, Inje University Haeundae Paik Hospital, Busan, Republic of Korea.

Neuroendocrine carcinoma of the cervix is rare, and prognosis is very poor. Because of its rarity, effective treatment of neuroendocrine carcinoma of the cervix has not been established. It has distinct patterns of metastasis, but can be successfully treated with radical surgery and platinum-based chemotherapy. Read More

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http://dx.doi.org/10.1159/000493912DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6243902PMC
October 2018
1 Read

Breast Cancer Metastasis in the Skin with Hyperkeratotic Pigmentation Caused by Melanocyte Colonization.

Case Rep Oncol 2018 Sep-Dec;11(3):660-664. Epub 2018 Oct 23.

Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai, Japan.

Pigmented breast cancer in the skin caused by nonneoplastic melanocytes of epidermal origin is a rare condition of metastasis from breast cancer, but the pathogenesis of this phenomenon is almost unknown. In this report, we describe a case of breast cancer metastasis in the skin with prominent hyperkeratotic pigmentation caused by nonneoplastic melanocyte colonization. Immunohistochemical staining revealed that the metastatic tumor cells produced IL-23, which is reported not only to induce IL-17 but also to inhibit cell apoptosis in breast cancer cells, which affects tumor progression. Read More

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http://dx.doi.org/10.1159/000493186DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6244098PMC
October 2018
9 Reads

Capecitabine-Associated Terminal Ileitis.

Case Rep Oncol 2018 Sep-Dec;11(3):654-659. Epub 2018 Oct 22.

Department of Internal Medicine, Catharina Hospital, Eindhoven, the Netherlands.

Capecitabine is an oral fluoropyrimidine used as adjuvant and palliative chemotherapy in patients with colorectal cancer. Diarrhea is a well-known side effect of capecitabine and 5-fluorouracil agents. We present a case with terminal ileitis as a rare adverse event of capecitabine treatment. Read More

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http://dx.doi.org/10.1159/000492781DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6243901PMC
October 2018
3 Reads

Thromboembolic Events Related to Treatment with Checkpoint Inhibitors: Report of Two Cases.

Case Rep Oncol 2018 Sep-Dec;11(3):648-653. Epub 2018 Oct 22.

Americas Oncologia, Department of Oncology, Hospital Samaritano, São Paulo, Brazil.

Despite the significant clinical benefits, checkpoint inhibition is associated with a unique spectrum of immune-related adverse events. It is sometimes difficult to distinguish some rare adverse effects from a cancer progression; thus, such effects should be reported in clinical trials to be diagnosed by physicians. Only a few cases of arterial embolic events have been described in studies related to patients treated by immunotherapy. Read More

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http://dx.doi.org/10.1159/000492463DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6243904PMC
October 2018
1 Read

Primary Gastrointestinal Kaposi's Sarcoma in a Patient with Human Immunodeficiency Virus.

Case Rep Oncol 2018 Sep-Dec;11(3):638-647. Epub 2018 Oct 22.

Internship in Medicine, Fundacion Universitaria Sanitas, Bogotá, Colombia.

Gastrointestinal bleeding in HIV patients secondary to coinfection by HHV8 and development of Kaposi's sarcoma (KS) is a rare complication even if no skin lesions are detected on physical examination. This article indicates which patients might develop this type of clinical sign and also tries to recall that absence of skin lesions never rules out the presence of KS, especially if gastrointestinal involvement is documented. Gastrointestinal bleeding in terms of hematemesis has rarely been reported in the literature. Read More

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http://dx.doi.org/10.1159/000492715DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6244015PMC
October 2018
10 Reads

Sarcomatoid Variant of Bladder Carcinoma: A Case Report.

Case Rep Oncol 2018 Sep-Dec;11(3):633-637. Epub 2018 Sep 13.

Departments of Urology and Renal Transplantation, Yokohama City University Medical Center, Yokohama, Japan.

A 59-year-old man was referred to our hospital complaining of asymptomatic gross hematuria. Cystoscopy revealed a papillary tumor 8 cm in diameter filling the bladder. The patient underwent transurethral resection of the bladder tumor. Read More

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https://www.karger.com/Article/FullText/492779
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http://dx.doi.org/10.1159/000492779DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6180258PMC
September 2018
10 Reads

Rechallenge with First-Line Platinum Chemotherapy for Sensitive-Relapsed Small-Cell Lung Cancer.

Case Rep Oncol 2018 Sep-Dec;11(3):622-632. Epub 2018 Sep 7.

Department of Respiratory Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.

Background: Sensitive-relapsed small-cell lung cancer (SCLC) is thought to be sensitive to chemotherapy; therefore, second-line chemotherapy is recommended. Although platinum rechallenge is performed in the second-line chemotherapy for sensitive-relapsed SCLC, it remains unclear whether such a strategy is effective.

Methods: We retrospectively analyzed the outcome of rechallenge chemotherapy for sensitive-relapsed SCLC. Read More

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https://www.karger.com/Article/FullText/492780
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http://dx.doi.org/10.1159/000492780DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6180263PMC
September 2018
12 Reads

Nivolumab-Induced Impressive Response of Refractory Pulmonary Sarcomatoid Carcinoma with Brain Metastasis.

Case Rep Oncol 2018 Sep-Dec;11(3):615-621. Epub 2018 Sep 7.

Department of Oncology, University of Modena and Reggio Emilia - Policlinico of Modena, Modena, Italy.

Background: Pulmonary sarcomatoid carcinoma is a rare, poorly differentiated, and highly aggressive type of non-small cell lung cancer. High tumor mutational burden and PD-L1 overexpression make it an excellent candidate for immunotherapy.

Objectives And Method: We presented the case of a patient who underwent left inferior lobectomy with concurrent right paravertebral muscular metastasectomy for an infiltrative neoplastic mass, whose final diagnosis was consistent with stage IV pulmonary sarcomatoid carcinoma. Read More

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https://www.karger.com/Article/FullText/492666
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http://dx.doi.org/10.1159/000492666DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6180262PMC
September 2018
5 Reads

Bowen's Disease of the Nipple.

Case Rep Oncol 2018 Sep-Dec;11(3):609-614. Epub 2018 Sep 7.

Department of Pathology, Ibaraki Prefectural Central Hospital and Cancer Center, Kasama, Japan.

Bowen's disease is a type of intraepidermal squamous cell carcinoma that commonly develops in areas of the skin exposed to sunlight, such as the scalp, trunk, and limbs. Although development of Bowen's disease in other sites, such as the nipple, is extremely rare, we herein report our experience with one such case. A 76-year-old female presented to our hospital with complaints of right nipple pruritus. Read More

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http://dx.doi.org/10.1159/000492382DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6180276PMC
September 2018
1 Read

Two Cases of Long-Term Survival of Advanced Colorectal Cancer with Synchronous Lung Metastases Treated with mFOLFOX6/XELOX + Bevacizumab.

Case Rep Oncol 2018 May-Aug;11(2):601-608. Epub 2018 Aug 29.

Department of Gastroenterology, Cancer Institute Hospital of the Japanese Foundation for Cancer Research, Tokyo, Japan.

Background: Colorectal cancer (CRC) with lung metastases has an unfavorable prognosis. However, nowadays, even advanced CRC can have a favorable outcome in certain cases. A complete response (CR) is a rare event in advanced CRC with lung metastases. Read More

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https://www.karger.com/Article/FullText/492568
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http://dx.doi.org/10.1159/000492568DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6167726PMC
August 2018
6 Reads

Extracranial Metastases of a Cerebral Glioblastoma: A Case Report and Review of the Literature.

Case Rep Oncol 2018 May-Aug;11(2):591-600. Epub 2018 Aug 28.

Department of Neurology, University of Cologne, Cologne, Germany.

The glioblastoma, a malignant human brain tumor, is known for its devastating intracranial progress and its dismal prognosis. Whereas treatment and research are most prominently focused on the primary tumor lesion, in recent years evidence has accumulated that points to the rare occurrence of extracranial glioblastoma metastases. We here present a case of a female patient with a known glioblastoma who was detected to harbor multiple metastases in the bones, lung, pleura, liver, mesentery, and the subcutaneous soft tissue. Read More

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https://www.karger.com/Article/FullText/492111
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http://dx.doi.org/10.1159/000492111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6167720PMC
August 2018
17 Reads

Hydrogen Sulfide and Hydrogen Sulfide-Synthesizing Enzymes Are Altered in a Case of Oral Adenoid Cystic Carcinoma.

Case Rep Oncol 2018 May-Aug;11(2):585-590. Epub 2018 Aug 27.

Department of Pathology, Louisiana State University Health Shreveport, Shreveport, Louisiana, USA.

Adenoid cystic carcinomas (ACC) constitute 1% of all head and neck malignancies and are very rare in the oral cavity. With < 60 oral ACCs described, their pathobiology is incompletely understood. Here, we report a case of oral cavity ACC in a 54-year-old woman. Read More

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http://dx.doi.org/10.1159/000492464DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6167701PMC
August 2018
16 Reads

Accurate Detection of Tumor Infiltration by C-Methionine Positron Emission Tomography in a Patient with Central Nervous System Intravascular Lymphoma: A Case Report.

Case Rep Oncol 2018 May-Aug;11(2):577-584. Epub 2018 Aug 23.

Jisenkai Brain Imaging Research Center, Aizawa Hospital, Matsumoto, Japan.

Intravascular lymphoma (IVL) is a rare and clinically devastating subtype of extranodal diffuse large B-cell lymphoma with a distinct presentation. Diagnostic difficulty derives from marked variability in clinical presentations and nonspecific laboratory and radiological findings, especially when central nervous system (CNS) symptoms are the only manifestation. Establishing the diagnosis premortem thus remains a major challenge. Read More

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http://dx.doi.org/10.1159/000492465DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6120372PMC
August 2018
1 Read

Acute Myeloid Leukemia with Myelodysplasia-Related Changes in a Patient with Crohn's Disease Treated with Immunosuppressive Therapy.

Case Rep Oncol 2018 May-Aug;11(2):573-576. Epub 2018 Aug 17.

The First Affiliated Hospital, Nanchang University, Nanchang, China.

We report a case of acute myeloid leukemia with myelodysplasia-related changes in a patient with Crohn's disease. The patient was diagnosed with Crohn's disease at the age of 47 years and was treated with the tumor necrosis factor α inhibitors adalimumab and infliximab, and a short course of azathioprine. Four years later, the patient developed acute myeloid leukemia with myelodysplasia that involved mainly erythropoiesis. Read More

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http://dx.doi.org/10.1159/000491573DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6120370PMC
August 2018
2 Reads

Leukoerythroblastosis with Cytopenia as an Initial Presentation of Lung Adenocarcinoma.

Case Rep Oncol 2018 May-Aug;11(2):567-572. Epub 2018 Aug 17.

Department of Pathology, Royal Victoria Regional Heath Centre, Barrie, Ontario, Canada.

A 74-year-old male with a history of chronic lymphocytic leukemia (CLL) previously treated with fludarabine/cyclophosphamide/rituximab (FCR) 5 years ago, presented with progressive fatigue, mucocutaneous bleeding, and cytopenias (hemoglobin 51 g/L, platelets 8.0 × 10/L, lymphocytes 0.4 × 10/L). Read More

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https://www.karger.com/Article/FullText/491920
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http://dx.doi.org/10.1159/000491920DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6120374PMC
August 2018
12 Reads

Sarcoid-Like Granulomatosis Induced by Nivolumab Treatment in a Lung Cancer Patient.

Case Rep Oncol 2018 May-Aug;11(2):562-566. Epub 2018 Aug 17.

Respiratory Medicine, Japanese Red Cross Wakayama Medical Center, Wakayama, Japan.

Nivolumab, an anti-PD-1 antibody, inhibits binding between PD-1 and PD-1 ligand and activates antigen-specific T cells that have become unresponsive to cancer cells. Although it is recommended as a second-line therapy in gene mutation-negative non-small-cell lung cancer, interstitial pneumonia is a well-known side effect of the drug; however, granulomatous lesions have rarely been reported. We describe the case of an 81-year-old male with cT1aN2M1b stage IV pleomorphic carcinoma of the left upper lobe of the lung. Read More

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http://dx.doi.org/10.1159/000492383DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6120371PMC
August 2018
21 Reads

Aromatase Inhibitor-Associated Tendinopathy and Muscle Tendon Rupture: Report of Three Cases of This Exceedingly Rare Adverse Event.

Case Rep Oncol 2018 May-Aug;11(2):557-561. Epub 2018 Aug 17.

Second Oncological Clinic, Agios Savvas Hospital, Athens, Greece.

Aromatase inhibitors (AIs) are a commonly used antihormonal therapy in the treatment of breast cancer in postmenopausal women, specifically in the treatment of hormone receptor-positive breast cancer. AI-associated tendinopathy and muscle tendon rupture is exceedingly rare. Until now, only one case with AI-associated severe tendinopathy has been reported in the medical literature, and there are no recorded cases of AI-associated muscle tendon rapture. Read More

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http://dx.doi.org/10.1159/000491874DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6120376PMC
August 2018
2 Reads

Severe Gastritis after Administration of Nivolumab and Ipilimumab.

Case Rep Oncol 2018 May-Aug;11(2):549-556. Epub 2018 Aug 17.

Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan.

Immune checkpoint inhibitors such as ipilimumab, a cytotoxic T-lymphocyte-associated antigen-4 inhibitor, have been widely used for advanced malignancies. As these inhibitors improve antitumor immunity via T-cell modulation, immune-mediated adverse events associated with T-cell activation, such as colitis, might occur. Herein, we describe a 75-year-old Japanese woman with metastatic malignant melanoma who developed hemorrhagic gastritis after ipilimumab treatment. Read More

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http://dx.doi.org/10.1159/000491862DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6120399PMC
August 2018
1 Read

Searching for the Culprit: Metastases from a Cancer of Unknown Primary.

Case Rep Oncol 2018 May-Aug;11(2):541-548. Epub 2018 Aug 10.

Oncology Research Unit, Médica Sur Hospital and Clinical Foundation, Mexico City, Mexico.

We report a case of metastases from a cancer of unknown primary whose primary site could not be identified during the appropriate pretreatment evaluation. The patient was a 58-year-old woman with a history of passive smoking and with no history of cancer in the family. Her current condition started with asthenia, adynamia, and pallor, followed by palpitations. Read More

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http://dx.doi.org/10.1159/000491600DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6120367PMC
August 2018
1 Read

A Case of Vanishing Metastatic Mass: Right Atrial Mass in the Setting of Primary Epithelioid Hemangioendothelioma of the Spine.

Case Rep Oncol 2018 May-Aug;11(2):534-540. Epub 2018 Aug 10.

New York-Presbyterian Brooklyn Methodist Hospital, Brooklyn, New York, USA.

Epithelioid hemangioendothelioma (EHE) is a rare low-grade vascular neoplasm that is characterized as intermediate between benign hemangioma and high-grade angiosarcoma affecting 1 in 1,000,000 people worldwide. It has been described throughout the body with lung, liver, skin, and bone being the most frequent sites. Primary EHE of the spine has been reported in 56 cases so far with no correlation of age and sex. Read More

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http://dx.doi.org/10.1159/000491529DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6120414PMC
August 2018
1 Read