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    Neuroendocrine Tumor Involving the Epicardium.
    Case Rep Oncol 2017 Sep-Dec;10(3):1144-1149. Epub 2017 Dec 20.
    Department of Hematology and Oncology, Mayo Clinic, Jacksonville, Florida, USA.
    Neuroendocrine tumors (NETs) are rare malignancies that usually arise from the digestive tract or lungs. Metastases of NETs to the heart (epicardium) are a rare complication. We present a case of a metastatic NET involving the epicardium. Read More

    High-Grade Left Atrial Pleomorphic Sarcoma: Case Report and Review.
    Case Rep Oncol 2017 Sep-Dec;10(3):1138-1143. Epub 2017 Dec 20.
    Department of Coronary Care Unit, Fundación Clínica Shaio, Bogotá, Colombia.
    Primary pleomorphic sarcoma of the left atrium is a rare tumor. There is no actual evidence of the management of this pathological entity, so the main treatment is individualized, surgical management being the cornerstone of the treatment. We present a 78-year-old female who had a clinical picture of heart failure, documenting an atrial mass of the left atrium, with high-grade pleomorphic sarcoma revealed in histopathology. Read More

    A Case of Paraneoplastic Remitting Seronegative Symmetrical Synovitis with Pitting Edema Syndrome Improved by Chemotherapy.
    Case Rep Oncol 2017 Sep-Dec;10(3):1131-1137. Epub 2017 Dec 20.
    Division of Medical Oncology, Department of Internal Medicine, Teikyo University School of Medicine, Tokyo, Japan.
    The patient was a 69-year-old male who had started experiencing acute-onset pain in both shoulder joints and edema of both hands and feet. His symptoms progressively worsened within 1 month. Laboratory data indicated elevated CRP and erythrocyte sedimentation rate despite the normal range of antinuclear antibodies and rheumatoid factor and normal organ function. Read More

    A Case of Advanced Submandibular Gland Cancer in Which Increased Prostate-Specific Antigen and Multiple Bone Metastases Wrongly Suggested Concurrent Prostate Cancer.
    Case Rep Oncol 2017 Sep-Dec;10(3):1127-1130. Epub 2017 Dec 20.
    Division of Medical Oncology, Department of Internal Medicine, Teikyo University School of Medicine, Tokyo, Japan.
    A 73-year-old man, followed for prostatic hyperplasia, developed submandibular gland cancer. Initially, because of the concurrent presence of elevated serum prostate-specific antigen (PSA) and multiple bone metastases, he was clinically determined as having stage IV prostate cancer in addition to stage II submandibular gland cancer, and radical surgery for his submandibular gland cancer was performed first. However, subsequent detailed examinations of the prostate gland showed no prostate cancer, and a diagnosis of advanced submandibular gland cancer with increased PSA and multiple bone metastases was established. Read More

    Downgrading of a G3 Neuroendocrine Tumor to a G2 Tumor: Can First-Line Cytotoxic Chemotherapy Change the Tumor Biology?
    Case Rep Oncol 2017 Sep-Dec;10(3):1121-1126. Epub 2017 Dec 20.
    Clinical Division of Gastroenterology and Hepatology, Department of Internal Medicine, Medical University of Graz, Graz, Austria.
    The antiproliferative treatment options for neuroendocrine tumors (NET)/neuroendocrine carcinomas of the gastrointestinal tract critically depend on the proliferation rate, evaluated by immunohistochemical staining for Ki-67. According to their grading, tumors are treated with somatostatin analogs, mTOR inhibitors, or cytotoxic substances. This case illustrates downgrading of a primarily highly proliferative NET achieved by a variation of cytotoxic chemotherapy regimens, followed by a combination therapy using everolimus together with lanreotide. Read More

    Idiopathic Thrombocytopenia Purpura Masking Hodgkin Disease: A Paraneoplastic Syndrome or Simply a Mere Association?
    Case Rep Oncol 2017 Sep-Dec;10(3):1116-1120. Epub 2017 Dec 19.
    Department of Hematology/Oncology, McLaren Oakland Hospital, Michigan State University College of Osteopathic Medicine, Pontiac, Michigan, USA.
    We report a 74-year-old female who presented to the emergency department complaining of bruising and stroke-like symptoms. She underwent a negative stroke work-up but was found to have profoundly low platelets and splenomegaly on examination. An abdominal CT scan was ordered, showing pelvic lymphadenopathy. Read More

    Herpes Encephalitis: A Mortal Complication in a Patient Treated with Immunosuppressive Drugs because of Immune-Related Adverse Events after Ipilimumab Treatment.
    Case Rep Oncol 2017 Sep-Dec;10(3):1112-1115. Epub 2017 Dec 18.
    Department of Medical Oncology, Maastricht University Medical Center, Maastricht, The Netherlands.
    Until a few years ago, metastatic melanoma had a poor prognosis with limited treatment options. These therapeutics options and thereby median survival have increased obviously over 5 years with the arrival of immunotherapeutic drugs like ipilimumab, nivolumab, and pembrolizumab. Nowadays, ipilimumab is often used in patients with metastatic melanoma. Read More

    Excision of an Elusive Tiny Ectopic Parathyroid Adenoma.
    Case Rep Oncol 2017 Sep-Dec;10(3):1105-1111. Epub 2017 Dec 11.
    Mater Dei Hospital, Triq Dun Karm, L-Imsida, Malta.
    An elderly lady was diagnosed with primary hyperparathyroidism after being admitted to hospital with pyelonephritis and constipation. A sestamibi parathyroid scan demonstrated increased uptake in the upper mediastinum, suggesting an ectopic mediastinal parathyroid adenoma. The 4-mm adenoma was successfully removed through a mini-sternotomy incision using a gamma probe to identify the gland from the surrounding tissue. Read More

    Durable and Complete Response to Herceptin Monotherapy in Patients with Metastatic Gastroesophageal Cancer.
    Case Rep Oncol 2017 Sep-Dec;10(3):1098-1104. Epub 2017 Dec 11.
    Banner MD Anderson Cancer Center, Gilbert, Arizona, USA.
    Gastroesophageal cancer is the sixth leading cause of cancer-related death worldwide. The 2 most common histologies are squamous cell carcinoma and adenocarcinoma, which has seen an increase in incidence correlating with an increase in obesity in developed countries. Gastroesophageal adenocarcinoma has a preponderance to metastasize early, making it a highly lethal cancer with a low 5-year survival rate of ∼15-25%. Read More

    Linfoma Nasal de Células T/Natural Killer Extranodal Refractario Mal Diagnosticado, Tratado de Manera Exitosa: Informe de Caso.
    Case Rep Oncol 2017 Sep-Dec;10(3):1092-1097. Epub 2017 Dec 11.
    Fundación Colombiana de Cancerología, Clínica Vida, Medellín, Colombia.
    El linfoma de células T/natural killer extranodal ("extranodal natural killer/T-cell lymphoma", ENKL) nasal es un linfoma no Hodgkin (LNH) agresivo y poco común para el cual no se ha establecido un tratamiento de referencia claro, especialmente en el escenario de la enfermedad recidivante/refractaria. Debido a su rareza, no se han llevado a cabo ensayos aleatorizados específicamente en ENKL nasal; sin embargo, los informes de caso y las series de caso pequeñas ofrecen un conocimiento importante sobre nuevos tratamientos potenciales. Presentamos el informe de caso de un paciente con ENKL nasal (previamente mal diagnosticado como una sinusitis crónica recidivante) en quien la enfermedad progresó durante la quimioterapia con múltiples agentes pero respondió al tratamiento de segunda línea con pralatrexato como agente único. Read More

    Pazopanib-Induced Cutaneous Leukocytoclastic Vasculitis: An Exclusion Diagnosis of a Multidisciplinary Approach.
    Case Rep Oncol 2017 Sep-Dec;10(3):1041-1049. Epub 2017 Nov 27.
    Dermatology Department, Instituto CUF de Oncologia (I.C.O.), Lisbon, Portugal.
    In phase II/III trials, cutaneous side effects of pazopanib were reported in less than 20% of patients, with only 1-3% being grade 3/4. We present a case of a 66-year-old man with a previous history of left nephrectomy for a stage II clear cell renal carcinoma. Approximately 18 months later, recurrent disease in the lungs, mediastinum, and left psoas and bulky abdominal/pelvic nodal metastasis were documented. Read More

    Long-Term Survival with Regorafenib in-Mutated Metastatic Rectal Cancer.
    Case Rep Oncol 2017 Sep-Dec;10(3):1029-1034. Epub 2017 Nov 20.
    Department of Oncology, Geneva University Hospital, Geneva, Switzerland.
    Regorafenib, an oral multikinase inhibitor, was approved in September 2012 by the US Food and Drug Administration for the treatment of patients with metastatic colorectal cancer progressing on standard therapies. Here, we describe the clinical history of a 63-year-old male patient who was treated with regorafenib in the pivotal CORRECT trial. The patient was initially diagnosed in November 2008 with nonmetastatic-mutated (exon 2, codon 12) rectal cancer. Read More

    Metachronous Development of Meningothelial Meningioma, Basal Cell Carcinoma, and Glioblastoma Multiforme in a Patient with Pancreatic Incidentaloma.
    Case Rep Oncol 2017 Sep-Dec;10(3):1023-1028. Epub 2017 Nov 16.
    Department of Medical Genetics, Medical University, Sofia, Bulgaria.
    We report the unique case of a 61-year-old male patient with known pancreatic incidentaloma who additionally developed 3 other histologically different tumors: left sphenoid wing meningothelial meningioma, basal cell carcinoma of the occiput, and right occipital lobe glioblastoma multiforme. The latter were totally removed with a favorable clinical outcome. The patient's family history was unremarkable, and no data on any previous head and neck irradiation were found. Read More

    A Case of Diffuse Large B-Cell Lymphoma Mimicking Primary Effusion Lymphoma-Like Lymphoma.
    Case Rep Oncol 2017 Sep-Dec;10(3):1013-1022. Epub 2017 Nov 16.
    Department of Community Medicine, Kanazawa Medical University Himi Municipal Hospital, Himi, Japan.
    A 93-year-old female was transferred to the emergency ward of our hospital due to disturbance of consciousness and hypotension. Computed tomography showed bilateral pleural and pericardial effusion without evidence of tumor masses or lymphadenopathy. Cytodiagnosis of pleural effusion revealed proliferation of atypical lymphoid-like cells with pan-B surface markers. Read More

    Metachronous and Synchronous Occurrence of 5 Primary Malignancies in a Female Patient between 1997 and 2013: A Case Report with Germline and Somatic Genetic Analysis.
    Case Rep Oncol 2017 Sep-Dec;10(3):1006-1012. Epub 2017 Nov 16.
    Department of Clinical Pathology and Genetics, Sahlgrenska University Hospital, Gothenburg, Sweden.
    The number of patients with multiple primary malignancies has been increasing steadily in recent years. In the present study, we describe a unique case of an 81-year-old woman with 5 metachronous and synchronous primary malignant neoplasms. The patient was first diagnosed with an endometrium adenocarcinoma in 1997 and a colon adenocarcinoma in 2002. Read More

    Durable Near-Complete Response to Anti-PD-1 Checkpoint Immunotherapy in a Refractory Malignant Solitary Fibrous Tumor of the Pleura.
    Case Rep Oncol 2017 Sep-Dec;10(3):998-1005. Epub 2017 Nov 13.
    WVU Cancer Institute, Mary Babb Randolph Cancer Center, West Virginia University, Morgantown, West Virginia, USA.
    Solitary fibrous tumor of the pleura is a rare and usually benign primary neoplasm arising from mesenchymal cells of the submesothelial tissue. We present here the case of a patient diagnosed with CD34-positive advanced malignant solitary fibrous tumor of the pleura whose disease failed to respond to combination cytotoxic chemotherapy agents, but demonstrated a prompt near-complete response to checkpoint blockade treatment using the anti-programmed death (PD)-1 monoclonal antibody pembrolizumab, based on tumor molecular profiling revealing tumoral expression positivity for both programmed death-ligand 1 (PD-L1) and PD-1. The patient experienced minimal adverse effects from the treatment with durable favorable response lasting up to cycle 26. Read More

    Occult Breast Carcinoma Presenting as Scalp Metastasis.
    Case Rep Oncol 2017 Sep-Dec;10(3):992-997. Epub 2017 Nov 10.
    Department of Breast Cancer, Lee Moffitt Cancer Center, Tampa, Florida, USA.
    Breast cancer is the most common tumor among women, and approximately 6% of the patients have de novo metastatic breast cancer. Occult breast cancer accounts for only 0.1-0. Read More

    A 48-Year-Old Male with Cutaneous Metastases of NUT Midline Carcinoma Misdiagnosed as Herpes Zoster.
    Case Rep Oncol 2017 Sep-Dec;10(3):987-991. Epub 2017 Nov 6.
    Department of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
    NUT (nuclear protein of the testis) midline carcinoma (NMC) is a rare, poorly differentiated neoplasm with dismal prognosis. Though NMC are often metastatic by the time of presentation, cutaneous metastases have not been well described in the literature. We report a case of NMC in a patient who presented with grouped well-demarcated tender non-ulcerated erythematous nodules on the right mid-back. Read More

    A Rare Differential Diagnosis of an Adrenal Mass: A Case Report.
    Case Rep Oncol 2017 Sep-Dec;10(3):981-986. Epub 2017 Nov 6.
    Department of Infectious Diseases, Kantonsspital Winterthur, Winterthur, Switzerland.
    Ten years after his last treatment for diffuse large B-cell lymphoma, a seemingly healthy, 64-year-old man presented for his lymphoma-related follow-up. Ultrasound revealed an impressive tumor in the right adrenal gland. Due to recurrent cancer therapies in the past, this seemed highly suspicious of a second malignancy, such as primary adrenal carcinoma. Read More

    A Rare Case of Docetaxel-Induced Hydrocephalus Presenting with Gait Disturbances Mimicking and Coexisting with Taxane-Associated Polyneuropathy: The Relevance of Differential Diagnosis, Clinical Assessment, and Response to Ventriculoperitoneal Shunt.
    Case Rep Oncol 2017 Sep-Dec;10(3):973-980. Epub 2017 Nov 6.
    Department of Neurosurgery, Offenbach Hospital, Offenbach am Main, Germany.
    Docetaxel constitutes a widely used chemotherapeutic agent as a first-line treatment for several neoplastic diseases. One of the most common side effects induced by this drug is polyneuropathy, which among other symptoms can cause gait disbalance. However, in exceptional cases gait disturbances could be related to docetaxel-induced hydrocephalus, a rare event that up to the present has been overseen throughout the medical literature and should be meticulously differentiated from polyneuropathy, since its clinical features, treatment, and prognosis differ drastically. Read More

    Minimal Change Disease as Initial Presentation of ALK-Positive Anaplastic Large-Cell Lymphoma in a Pediatric Patient.
    Case Rep Oncol 2017 Sep-Dec;10(3):964-972. Epub 2017 Nov 6.
    Division of Nephrology, Department of Pediatrics, University of Florida, Gainesville, Florida, USA.
    The association between nephrotic syndrome (NS), hemophagocytic lymphohistiocytosis (HLH), and certain paraneoplastic syndromes has been documented in the literature. However, nephrotic changes as part of paraneoplastic syndromes are rare in lymphoid malignancies, particularly in non-Hodgkin lymphoma. We report the sudden onset of acute renal failure and NS in a 14-year-old male who initially presented with HLH and was subsequently diagnosed with ALK-positive anaplastic large-cell lymphoma (ALCL). Read More

    Endocrine Health Problems Detected in 764 Patients Evaluated in a Late Effects Clinic.
    Case Rep Oncol 2017 Sep-Dec;10(3):958-963. Epub 2017 Oct 31.
    Endocrine and Neurological Department, Portuguese Cancer Institute FG, Lisbon, Portugal.
    Background: Many pediatric cancer survivors have endocrine conditions. After treatment with alkylating agents, steroids, methotrexate, and radiation, several endocrine dysfunctions may appear. Surveillance for late effects is recommended by guidelines worldwide. Read More

    Pazopanib and Statin-Induced Rhabdomyolysis.
    Case Rep Oncol 2017 Sep-Dec;10(3):954-957. Epub 2017 Oct 31.
    Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.
    Background: The VEGF inhibitor pazopanib is a widely used first-line therapy for the treatment of advanced renal cell carcinoma. Potential drug-drug interactions and toxicities may be underrecognized.

    Case Presentation: A 73-year-old woman with metastatic renal cell carcinoma on treatment with pazopanib presented with progressive inability to ambulate. Read More

    Misdiagnosed Refractory Extranodal Natural Killer/T-Cell Lymphoma, Nasal Type, Successfully Treated: A Case Report.
    Case Rep Oncol 2017 Sep-Dec;10(3):948-953. Epub 2017 Oct 26.
    Fundación Colombiana de Cancerología, Clínica Vida, Medellín, Colombia.
    Extranodal natural killer/T-cell lymphoma (ENKL), nasal type, is a rare, aggressive non-Hodgkin lymphoma for which no clear standard of care has been established, particularly in the relapsed/refractory disease setting. Because of its rarity, randomized trials are not conducted specifically on ENKL, nasal type; however, case reports and small case series can provide important insights into potential new treatments. We present a case report of a patient with ENKL, nasal type (previously misdiagnosed as relapsing chronic sinusitis), whose disease progressed during multi-agent chemotherapy but responded to second-line treatment with single-agent pralatrexate. Read More

    Immune Thrombocytopenia as a Consequence of Rocky Mountain Spotted Fever.
    Case Rep Oncol 2017 Sep-Dec;10(3):945-947. Epub 2017 Oct 23.
    Department of Oncology, University of Florida, Jacksonville, Florida, USA.
    Primary immune thrombocytopenia (ITP) - also called idiopathic thrombocytopenic purpura or immune thrombocytopenic purpura - is an acquired thrombocytopenia caused by autoantibodies against platelet antigens. It is one of the more common causes of thrombocytopenia in otherwise asymptomatic adults. Rocky Mountain spotted fever (RMSF) is a potentially lethal, but curable, tick-borne disease. Read More

    Undiagnosed Esophageal Adenocarcinoma Presenting as Multiple Brain Metastases.
    Case Rep Oncol 2017 Sep-Dec;10(3):938-944. Epub 2017 Oct 20.
    St. Mary's of Michigan, Saginaw, Michigan, USA.
    Brain metastases from gastrointestinal malignancies are exceedingly rare occurrences that carry a very poor prognosis. This holds especially true in cases where brain metastases from esophageal primaries are the initial presentation of a previously unidentified gastrointestinal malignancy. Our patient, a 60-year-old male with a past history of a right temporal teratoma, family history of breast cancer, and no smoking history, presented with a chief complaint of recurrent headaches. Read More

    A Case of Thyroid Papillary Carcinoma: Remarkable Decrease in Multiple Lung Metastases within 40 Years after a Single Administration of Radioiodine without Thyroidectomy and with Later Anaplastic Transformation.
    Case Rep Oncol 2017 Sep-Dec;10(3):928-937. Epub 2017 Oct 17.
    Department of Radiology, Graduate School of Kyoto Prefectural University of Medicine, Kyoto, Japan.
    Differentiated thyroid carcinoma is an uncommon malignancy of childhood and adolescence that is unique because it has an overall favorable prognosis despite its relatively high rate of nodal and distant metastases. Total thyroidectomy and positiveI therapy are recommended for cases with pulmonary metastases. In contrast, anaplastic thyroid cancer is one of the most aggressive malignancies that have an unfavorable and miserable prognosis. Read More

    A Rare Case of Classical Hodgkin Lymphoma Diagnosed 10 Years after Liver Transplant.
    Case Rep Oncol 2017 Sep-Dec;10(3):923-927. Epub 2017 Oct 17.
    Oncology Institute of Southern Switzerland, Bellinzona, Switzerland.
    Posttransplant lymphoproliferative disorders (PTLD) represent a rare and potentially life-threatening complication after liver transplantation. Classical Hodgkin lymphoma (cHL), with an incidence of approximately 1.8-3. Read More

    Long-Term Survival of a Patient with Adenocarcinoma of the Esophagogastric Junction with a Portal Vein Tumor Thrombosis Who Underwent Palliative Total Gastrectomy: A Case Report.
    Case Rep Oncol 2017 Sep-Dec;10(3):916-922. Epub 2017 Oct 17.
    Department of Surgery, Haeundae Paik Hospital, Inje University College of Medicine, Busan, Republic of Korea.
    Portal vein tumor thrombosis (PVTT) with advanced gastric cancer is very rare; when it occurs, it exhibits aggressive growth and carries a poor prognosis. In addition, definitive treatment has not been established due to insufficient data. Herein, we report a case of PVTT associated with an adenocarcinoma of the esophagogastric junction that was successfully controlled by means of a palliative total gastrectomy without surgical resection of the PVTT and administration of palliative continuous doxifluridine. Read More

    Recurrent Masses after Testicular Cancer: Growing Teratoma Syndrome. A Case Report and Review of the Literature.
    Case Rep Oncol 2017 Sep-Dec;10(3):910-915. Epub 2017 Oct 17.
    Department of Oncology, CHU UcL Namur, Yvoir, Belgium.
    Background: Growing teratoma syndrome is a rare syndrome that affects patients with nonseminomatous germ-cell tumors (NSGCTs). It is characterized by recurrent growing masses that appear during or after chemotherapy in the presence of normal levels of tumor markers. Histological examination is the only way to confirm the diagnosis. Read More

    Immune Checkpoint Inhibitor-Associated Type 1 Diabetes Mellitus: Case Series, Review of the Literature, and Optimal Management.
    Case Rep Oncol 2017 Sep-Dec;10(3):897-909. Epub 2017 Oct 17.
    Division of Hematology and Oncology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
    With the introduction of immune checkpoint inhibitors into clinical practice, various autoimmune toxicities have been described. Antibodies targeting the receptor:ligand pairing of programmed death receptor-1 (PD-1) and its cognate ligand programmed death-ligand 1 (PD-L1) in rare reports have been associated with autoimmune diabetes mellitus. We report 2 cases of rapid-onset, insulin-dependent, type 1 diabetes mellitus in the setting of administration of nivolumab, a fully human monoclonal antibody to PD-1, and atezolizumab, a humanized monoclonal antibody to PD-L1. Read More

    A Solitary Intestinal Myofibroma: A Rare Cause of Neonatal Anemia.
    Case Rep Oncol 2017 Sep-Dec;10(3):890-896. Epub 2017 Oct 17.
    Department of Pediatric Oncology, Hematology and BMT, BC Children's Hospital, Vancouver, British Columbia, Canada.
    Solitary infantile myofibroma with visceral involvement is very rare. We present an unusual case of a solitary myofibroma with abdominal localization in a 1-day-old female neonate who presented with severe anemia and rectal bleeding. A bleeding myofibroma was found, located in the wall of the jejunum, and totally resected. Read More

    Near Complete Response in a Patient with Classical Hodgkin Lymphoma Treated with Brentuximab Vedotin Concurrent with Radiation Therapy.
    Case Rep Oncol 2017 Sep-Dec;10(3):795-801. Epub 2017 Sep 6.
    Oklahoma State University - Tulsa, Tulsa, OK, USA.
    Brentuximab vedotin, an antibody drug conjugate that delivers monomethyl auristatin E into CD-30 expressing cells is FDA approved for the treatment of patients with Hodgkin lymphoma after the failure of autologous stem cell transplantation or at least 2 prior multi-agent chemotherapy regiments. This approval was based on a study that showed an overall response rate of 75% and complete remission in 34%. We present a case of a 24-year-old male with classical nodular sclerosing Hodgkin lymphoma who achieved near complete remission following 5 cycles of brentuximab concurrent with ISRT (involved site radiation therapy) following progression of first-line ABVD (Adriamycin, bleomycin, vinblastine, dacarbazine) and subsequent second-line ICE (ifosfamide, carboplatin, etoposide) chemotherapy. Read More

    Oxaliplatin-Induced Hyperammonemic Encephalopathy in a Patient with Metastatic Pancreatic Cancer: A Case Report.
    Case Rep Oncol 2017 Sep-Dec;10(3):885-889. Epub 2017 Oct 10.
    Department of Medical Oncology, Kobe City Medical Center General Hospital, Kobe, Japan.
    Oxaliplatin-based chemotherapy is widely used to treat advanced cancer. Oxaliplatin-induced hyperammonemic encephalopathy is rarely reported. Here, we report a case of oxaliplatin-induced hyperammonemic encephalopathy occurring after gemcitabine plus oxaliplatin (GEMOX) chemotherapy in a patient with pancreatic cancer. Read More

    Spontaneous Remission of Severe Systemic Langerhans Cell Histiocytosis with Bladder Involvement: A Case Study.
    Case Rep Oncol 2017 Sep-Dec;10(3):876-884. Epub 2017 Oct 5.
    Department of Gynecology and Gynecological Oncology, Hospital for Women, University Hospital Basel, Basel, Switzerland.
    Background: The clinical presentation of Langerhans cell histiocytosis (LCH) is heterogeneous ranging from single-organ involvement to systemic disease causing substantial morbidity and mortality. We describe an unusual course of severe multisystem LCH with spontaneous remission.

    Case Presentation: We report on a 45-year-old Caucasian woman with cervical cancer, FIGO stage IVB. Read More

    Transplant-Ineligible Symptomatic but Indolent Multiple Myeloma Shows Better Prognosis with Conventional Agents.
    Case Rep Oncol 2017 Sep-Dec;10(3):871-875. Epub 2017 Oct 5.
    First Department of Internal Medicine, Kansai Medical University, Hirakata, Japan.
    The survival of multiple myeloma patients has improved significantly over the last several decades. However, the median overall survival of these patients remains less than 5 years. In this report, we discuss 4 cases of multiple myeloma patients that showed long survival. Read More

    Successful Treatment of Cardiac Angiosarcoma Associated with Disseminated Intravascular Coagulation with Nab-Paclitaxel: A Case Report and Review of the Literature.
    Case Rep Oncol 2017 Sep-Dec;10(3):863-870. Epub 2017 Sep 21.
    Department of Clinical Oncology, Aichi Cancer Center Hospital, Nagoya, Japan.
    Angiosarcoma of the heart is an uncommon soft tissue sarcoma. A few cases of disseminated intravascular coagulation (DIC) associated with angiosarcoma occurring in various organs, but not the heart, have been reported. Although taxane is commonly used in the treatment of metastatic angiosarcoma, data on the efficacy of nab-paclitaxel for angiosarcoma are limited. Read More

    Liquid Biopsy Prevents Inaccurate Her2 Status Determination by in situ Hybridization in a Patient with Invasive Ductal Adenocarcinoma of the Breast: Case Report.
    Case Rep Oncol 2017 Sep-Dec;10(3):857-862. Epub 2017 Sep 21.
    CellMax Inc., Sunnyvale, California, USA.
    Utilization of circulating tumor DNA as a novel and noninvasive test for diagnosis confirmation, therapy selection, and cancer surveillance is a rapidly growing area of interest. In the wake of FDA approval of a liquid biopsy test, it is important for clinicians to acknowledge the obvious clinical utility of liquid biopsy for cancer management throughout the course of the disease. This case report describes a female with invasive ductal adenocarcinoma of the breast, where liquid biopsy was instrumental for her cancer characterization and personalized therapy selection. Read More

    Primary Hepatic Angiosarcoma: A Case Report with 10-Year Patient Medical Data.
    Case Rep Oncol 2017 Sep-Dec;10(3):851-856. Epub 2017 Sep 20.
    Division of Clinical Infectious Diseases, Department of Infection and Immunity, Jichi Medical University, Tochigi, Japan.
    In the current study, we report a case of a 46-year-old man who presented with sudden abdominal pain and was diagnosed with rupture of hepatic angiosarcoma (HAS). He underwent surgery, but died 13 days after the onset of the abdominal pain. Chronic exposure to carcinogens, such as thorium dioxide, arsenic, vinyl chloride, and radium, is associated with HAS. Read More

    Burned-Out Testicular Cancer: Really a Different History?
    Case Rep Oncol 2017 Sep-Dec;10(3):846-850. Epub 2017 Sep 20.
    Policlinico Umberto I, Rome, Italy.
    Two or more histological types characterize more than 60% of testicular germ cell tumors (GCTs). Burned-out testicular tumor refers to partial or complete histological regression of the primary testicular lesions. The most frequent GCT type involved in this kind of histological regression is choriocarcinoma, followed by embryonal carcinoma. Read More

    Treatment of Leptomeningeal Metastases in a Patient with Non-Small Cell Lung Cancer Harboring EGFR T790M Mutation.
    Case Rep Oncol 2017 Sep-Dec;10(3):840-845. Epub 2017 Sep 20.
    Department of Medical Oncology, Banner MD Anderson Cancer Center, Gilbert, AZ, USA.
    Background: Leptomeningeal metastasis (LM) is an uncommon complication in patients with solid tumors, associated with poor survival. However, LM appears to be more frequent in lung cancer patients with EGFR mutations, posing a unique clinical challenge to treating physicians.

    Case Presentation: We report the case of a 68-year-old Asian man with metastatic lung adenocarcinoma harboring an EGFR L858R mutation, which was initially treated with gefitinib. Read More

    An Uncommon Presentation of a Metachronous Testicular Primary Nonseminoma and Seminoma Separated by Two Decades and a Testicular Cancer Literature Review.
    Case Rep Oncol 2017 Sep-Dec;10(3):832-839. Epub 2017 Sep 15.
    Cancer Treatment Centers of America, Southwestern Regional Center, Tulsa, OK, USA.
    Introduction: Testicular cancer is the most common malignancy in men aged 15-40 years [Bols et al.: Philadelphia, Wolters Kluwer, Lippincott Williams & Wilkins, 2011]. Its incidence comprises 0. Read More

    Recurrence of Ovarian Cancer with Placental Metastasis: A Case Report.
    Case Rep Oncol 2017 Sep-Dec;10(3):824-831. Epub 2017 Sep 15.
    Department of Obstetrics and Gynecology, Japanese Red Cross Medical Center, Tokyo, Japan.
    A 39-year-old primiparous Japanese female was admitted to the obstetrical emergency department of our hospital because of respiratory distress resulting from a large amount of pleural effusion, soon after a caesarean delivery (CD) at another hospital. While she was undergoing the CD, a giant ovarian tumour was identified. However, the tumour could not be removed at that facility and she was transferred to our hospital. Read More

    Pancreatic Adenocarcinoma Masquerading as Idiopathic Chronic Pancreatitis with Delayed Diagnosis.
    Case Rep Oncol 2017 Sep-Dec;10(3):819-823. Epub 2017 Sep 14.
    Hurley Medical Center/Michigan State University, Flint, Michigan, USA.
    Pancreatic cancer carries poor prognosis. Establishing the diagnosis early could help in improving outcome. We are presenting a case of pancreatic cancer with delayed diagnosis. Read More

    Dramatic Response with Single-Agent Ibrutinib in Multiply Relapsed Marginal Zone Lymphoma with MYD88Mutation.
    Case Rep Oncol 2017 Sep-Dec;10(3):813-818. Epub 2017 Sep 12.
    Division of Oncology, Department of Medicine, Stanford University School of Medicine, Stanford, California, USA.
    The B-cell receptor signaling pathway is important in the lymphomagenesis of many lymphomas, including marginal zone lymphoma (MZL). Herein we describe a case of extranodal MZL refractory to multiple lines of therapy. The presence of an IgM paraprotein prompted further evaluation, and the patient was found to have an MYD88mutation. Read More

    Nivolumab-Induced Myocarditis Concomitant with Myasthenia Gravis.
    Case Rep Oncol 2017 Sep-Dec;10(3):809-812. Epub 2017 Sep 6.
    Department of Medical Oncology, Teikyo University School of Medicine, Tokyo, Japan.
    We report a 69-year-old female patient with advanced lung cancer who developed myocarditis concomitant with myasthenia gravis (MG), also known as "Herzmyasthenie," after 3 cycles of nivolumab administration. Her initial symptoms were general malaise and double vision. However, her myocarditis deteriorated rapidly the following day, necessitating a temporary pacemaker and noninvasive positive pressure ventilation in the intensive care unit. Read More

    Different Response to Nivolumab in a Patient with Synchronous Double Primary Carcinomas of Hypopharyngeal Cancer and Non-Small-Cell Lung Cancer.
    Case Rep Oncol 2017 Sep-Dec;10(3):802-808. Epub 2017 Sep 6.
    Department of Thoracic Oncology, Aichi Cancer Center Hospital, Nagoya, Japan.
    Nivolumab is a humanized IgG4 and programmed death 1 (PD-1) monoclonal antibody that has demonstrated antitumor efficacy in clinical trials of various malignant tumors including non-small-cell lung cancer and head and neck squamous cell carcinoma (SCC). However, patients with multiple primary malignancies were excluded in clinical trials. Thus, the efficacy of nivolumab in such patients has not been revealed yet. Read More

    Fatal Acute Liver Failure as a Consequence of Regorafenib Treatment in a Metastatic Colon Cancer.
    Case Rep Oncol 2017 May-Aug;10(2):790-794. Epub 2017 Aug 29.
    Digestive Tumors Unit, Institut Bergonié, Bordeaux, France.
    Regorafenib is a multikinase inhibitor which showed benefits in pretreated metastatic colorectal cancer patients. Hepatotoxicity has been described as a frequent side effect. We report the case of a 65-year-old patient presenting with jaundice, fever, and hepatocellular insufficiency which led to death of the patient. Read More

    Nedaplatin as a Single-Agent Chemotherapy May Support Palliative Therapy for Patients with Adenoid Cystic Carcinoma: A Case Report.
    Case Rep Oncol 2017 May-Aug;10(2):783-789. Epub 2017 Aug 23.
    Department of Otorhinolaryngology, Tohoku Medical and Pharmaceutical University Hospital, Sendai, Japan.
    Adenoid cystic carcinoma (ACC) is a rare form of adenocarcinoma, which is a broad term describing any cancer that begins in the glandular tissues. It can be found in the head and neck. We report a patient with recurrent ACC arising from the submandibular gland, treated with 100 mg/mnedaplatin every 4 weeks. Read More

    What Is Different in the Population of the Brazilian Amazon Region so that They Have a Low Frequency of KRAS Gene Mutations?
    Case Rep Oncol 2017 May-Aug;10(2):777-782. Epub 2017 Aug 23.
    Oncologica do Brasil - Ensino e Pesquisa, Belém, Brazil.
    Background: Colorectal cancer (CRC) has been described in the medical literature as resulting from many forms of interaction between lifestyle, genetics, and geographical origin. Genetically, the KRAS gene has a negative impact on the general survival and prognosis of patients when mutated.

    Methods: This study was conducted in Brazil and included information about 60 patients with CRC stage III and IV examined at the Day Hospital Oncológica do Brasil, whose DNA was analyzed with the PCR-DNA method to determine the existence of a KRAS mutation. Read More

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