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    1050 results match your criteria Case reports in oncology[Journal]

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    Treatment of Leptomeningeal Carcinomatosis in a Patient with Metastatic Pancreatic Cancer: A Case Report and Review of the Literature.
    Case Rep Oncol 2018 May-Aug;11(2):281-288. Epub 2018 May 17.
    Walter Reed National Military Medical Center, Bethesda, Maryland, USA.
    Pancreatic cancer is the fourth leading cause of cancer-related death with a median survival of 3-11 months when metastatic. We present a patient with metastatic pancreatic cancer and an exceptional response to initial systemic chemotherapy with FOLFIRINOX (fluorouracil, leucovorin, irinotecan, and oxaliplatin). Despite evidence of disease control on body imaging, he developed symptomatic leptomeningeal disease and brain metastases 29 months into treatment. Read More

    Concomitant Radioembolization and Immune Checkpoint Inhibition in Metastatic Renal Cell Carcinoma.
    Case Rep Oncol 2018 May-Aug;11(2):276-280. Epub 2018 May 17.
    Department of Medical Oncology and Experimental Therapeutics, City of Hope Comprehensive Cancer Center, Duarte, California, USA.
    This case represents the challenge and creativity necessary when treating patients with metastatic renal cell carcinoma who have been exposed to multiple lines of therapy. At present, treatment with immune checkpoint inhibition has stabilized and improved the metastatic disease of this patient with the exception of hepatic lesions. This isolated progression within the liver led the employment of radioembolization, which successfully treated those metastases. Read More

    Novel Treatment Setup for Urethral Cancer: Use of the Prone Technique for Radiotherapy of the Penis.
    Case Rep Oncol 2018 May-Aug;11(2):268-275. Epub 2018 May 2.
    Department of Radiation Oncology, Keck School of Medicine of USC, USC Norris Comprehensive Cancer Center, Los Angeles, California, USA.
    Urethral cancer (UC) is a rare malignancy with a poor prognosis. Since local recurrence is common and associated with morbidity, case series have reported on the use of adjuvant radiotherapy. Radiotherapy treatment setup for malignancies of the penis can be challenging because of variability in anatomic positioning. Read More

    Everolimus Reduces the Size of Tuberous Sclerosis Complex-Related Huge Renal Angiomyolipomas Exceeding 20 cm in the Longest Diameter.
    Case Rep Oncol 2018 May-Aug;11(2):258-267. Epub 2018 May 2.
    Nephrology Center, Toranomon Hospital, Tokyo, Japan.
    We evaluated the efficacy of everolimus in 3 patients who had huge renal angiomyolipomas associated with tuberous sclerosis complex. Two patients with large lipid-rich angiomyolipomas had a history of renal transarterial embolization for renal bleeding, but the effect had only been temporary and the embolized kidneys had continued to enlarge. In case 1, case 2, and case 3, total renal volume was respectively 3,891, 4,035, and 1,179 cm before administration of everolimus, decreasing to 3,016 (77%), 3,043 (75%), and 1,051 (89%) cm after 1 year of everolimus therapy and to 2,832 (73%), 3,209 (80%), and 1,102 (93%) cm after 3 years. Read More

    Second-Line Treatment of HER2-Positive Salivary Gland Tumor: Ado-Trastuzumab Emtansine (T-DM1) after Progression on Trastuzumab.
    Case Rep Oncol 2018 May-Aug;11(2):252-257. Epub 2018 May 2.
    Division of Medical Oncology, Hospital Sírio-Libanês, Brasilia, Brazil.
    Patients with salivary duct cancer (SDC) and HER2 overexpression could receive trastuzumab in combination with chemotherapy for metastatic disease. No standard treatment exists for patients with HER2-positive metastatic SDC after progression. We report an excellent patient response to second-line treatment with T-DM1 after progression on paclitaxel plus trastuzumab. Read More

    Long-Term Progression-Free Survival in a Patient with Metastatic Leiomyosarcoma of the Inguinal Region Treated with Trabectedin.
    Case Rep Oncol 2018 Jan-Apr;11(1):246-251. Epub 2018 Apr 19.
    Tumor Center, Salzkammergut-Klinikum Vöcklabruck, Vöcklabruck, Austria.
    Presented here is the case of an elderly leiomyosarcoma patient with multiple comorbidities and relapses from prior lines of treatment, who experienced a long-lasting progression-free survival. After initial diagnosis, standard treatment protocols with surgery and subsequent adjuvant radiochemotherapy were administered, followed by a short course of oral pazopanib at the patient's request, which led to a rapid relapse. Afterwards, the patient received trabectedin for 22 months, achieving disease control with good quality of life over an extended period of time. Read More

    Successful Clarithromycin Monotherapy in a Patient with Primary Follicular Lymphoma of the Duodenum.
    Case Rep Oncol 2018 Jan-Apr;11(1):239-245. Epub 2018 Apr 11.
    Clinical Division of Oncology, Department of Medicine I, Medical University of Vienna, Vienna, Austria.
    Primary follicular lymphoma of the duodenum (FL-D) constitutes a rare subtype of extranodal follicular lymphoma with a usually indolent course. To date, no distinct treatment recommendations have been defined for those patients. We report the case of a 58-year-old male patient presenting with endoscopically assessed, symptomatic FL-D who was treated with clarithromycin monotherapy in analogy to recent data for mucosa-associated lymphoid tissue lymphoma. Read More

    Bexarotene-Induced Hypertriglyceridemia: A Case Report.
    Case Rep Oncol 2018 Jan-Apr;11(1):234-238. Epub 2018 Apr 11.
    Oncology Clinic, UMass Memorial Medical Center, Worcester, Massachusetts, USA.
    We present a case of a patient with cutaneous T-cell lymphoma started on bexarotene 300 mg/m due to progressing disease. The patient experienced good clinical response, but unfortunately, she developed rapid and profound hypertriglyceridemia. Although hypertriglyceridemia occurs in high incidence with bexarotene therapy, management recommendations are scarce. Read More

    Tuberculous Meningitis during Chemotherapy for Advanced Gastric Cancer.
    Case Rep Oncol 2018 Jan-Apr;11(1):228-233. Epub 2018 Apr 5.
    Department of Gastroenterology and Gastrointestinal Oncology, National Cancer Center Hospital East, Kashiwa, Japan.
    Introduction: Tuberculous meningitis is rare but one of the most severe forms of tuberculosis infection.

    Case Report: A 78-year-old woman was diagnosed with advanced gastric cancer with multiple lymph node metastases. Four months after the beginning of second-line chemotherapy with weekly paclitaxel, she was admitted to our hospital because of fever and mild drowsiness. Read More

    Gemcitabine-Induced Cardiotoxicity in Patients Receiving Adjuvant Chemotherapy for Pancreatic Cancer: A Case Series.
    Case Rep Oncol 2018 Jan-Apr;11(1):221-227. Epub 2018 Apr 5.
    Queen Elizabeth Hospital, Birmingham, United Kingdom.
    Gemcitabine is not considered a cardiotoxic agent generally; so far only very few case reports have been reported in the literature on different aspects of cardiac side effects. Here we report a case series of 3 patients who developed congestive cardiac failure, when treated with gemcitabine monotherapy in the adjuvant setting for pancreatic cancers. Adjuvant chemotherapy with gemcitabine has been the standard of care for pancreatic cancer patients after successful surgery since the results of the CONKO-001 and ESPAC3 study were published. Read More

    Radiation-Associated Angiosarcoma of the Breast: A Case Report and Literature Review.
    Case Rep Oncol 2018 Jan-Apr;11(1):216-220. Epub 2018 Apr 6.
    Division of Hematology Oncology, Department of Medicine, University of California Irvine Medical Center, Orange, California, USA.
    In the last couple of decades, breast conservation therapy, which utilizes a combination of surgery, radiotherapy, and endocrine or chemotherapy, has become the standard of care for treating early-stage breast cancer. This practice has been greatly beneficial in the improvement of the patient's quality of life but has also led to the increased use of radiotherapy and associated soft-tissue sarcomas, with angiosarcoma being the most common malignancy. Radiation-associated angiosarcoma (RAS) of the breast is a rare phenomenon, which has been reported to occur in approximately 0. Read More

    Successful Treatment of Advanced Primary Cutaneous Peripheral T-Cell Lymphoma with Oral Bexarotene Monotherapy.
    Case Rep Oncol 2018 Jan-Apr;11(1):212-215. Epub 2018 Mar 28.
    Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai, Japan.
    Bexarotene is a third-generation retinoid X receptor-selective retinoid that is widely used for the early treatment of advanced-stage cutaneous T-cell lymphomas. In this report, we describe a case of successful treatment of advanced primary cutaneous peripheral T-cell lymphoma not otherwise specified (PTCL-NOS) with oral bexarotene monotherapy. After the administration of oral bexarotene at a dose of 300 mg/m/day, all skin lesions and lymph nodes regressed, and complete remission was achieved for 1 year. Read More

    Mullerianosis of the Urinary Bladder: A Case Report.
    Case Rep Oncol 2018 Jan-Apr;11(1):206-211. Epub 2018 Mar 27.
    Pathology Services Division, Johns Hopkins Aramco Healthcare, Dhahran, Saudi Arabia.
    Mullerianosis is a rare entity consisting of an admixture of 2 or more of the following tissues: endometriosis, endocervicosis, and endosalpingiosis. It most commonly affects the urinary bladder and affects females of fertile age. It presents clinically as hematuria, dysuria, and pelvic pain which may be associated with menstruation. Read More

    Genomic Profiling of Two Histologically Distinct Rare Urothelial Cancers in a Clinical Setting to Identify Potential Therapeutic Options for Treatment and Management of Disease.
    Case Rep Oncol 2018 Jan-Apr;11(1):196-205. Epub 2018 Mar 27.
    The Jackson Laboratory for Genomic Medicine, Farmington, Connecticut, USA.
    Molecular profiling of urothelial cancers for therapeutic and prognostic potential has been very limited due to the absence of cancer-specific targeted therapies. We describe here 2 clinical cases with a histological diagnosis of an invasive sarcomatoid and a poorly differentiated carcinoma favoring urothelial with some neuroendocrine differentiation, two of the rarer types of urothelial cancers, which were evaluated for mutations in 212 genes for single-nucleotide variants and copy-number variants and 53 genes for fusions associated with solid tumors. In both cases, we identified variants in 2 genes, and , indicative of the role of dysregulation of chromatin remodeling and cell cycle control as being common features of bladder cancer, consistent with the proposed model of tumorigenesis in these rare, highly aggressive pathological subtypes. Read More

    Use of Eltrombopag in Improving Poor Graft Function after Allogeneic Hematopoietic Stem Cell Transplantation.
    Case Rep Oncol 2018 Jan-Apr;11(1):191-195. Epub 2018 Mar 27.
    Division of Hematology and Oncology, Louisiana State University Health Sciences Center, Shreveport, Louisiana, USA.
    Eltrombopag is a thrombopoietin agonist and has been used in aplastic anemia and post-transplantation thrombocytopenia. The c-MPL receptor is present on hematopoietic stem cells. There are no reports of eltrombopag utilization for improving poor graft function in the post-transplant setting. Read More

    Avascular Necrosis of Bone following Chemotherapy in Cancer Patients with Coagulopathy: Report of Two Cases.
    Case Rep Oncol 2018 Jan-Apr;11(1):185-190. Epub 2018 Mar 27.
    Division of Hemato-Oncology, Department of Internal Medicine, Chang-Gung Memorial Hospital and Chang-Gung University College of Medicine, Taoyuan, Taiwan.
    We report 2 cases of patients with solid tumors and coagulopathy who experienced avascular necrosis (AVN) of the bone following chemotherapy. Both cases exhibited nontraumatic bilateral AVN of the femoral heads, and one also showed bilateral AVN of the humeral heads. One case had multiple thromboembolic complications, including pulmonary obstructive syndrome and paraneoplastic pain. Read More

    Successful Limb-Sparing Wide Excision of a Giant Lipofibromatosis in a 5-Year-Old Girl.
    Case Rep Oncol 2018 Jan-Apr;11(1):179-184. Epub 2018 Mar 20.
    Surgical Oncology Subdivision, Department of Surgery, School of Medicine, Udayana University-Sanglah General Hospital, Denpasar, Indonesia, Denpasar, Indonesia.
    A 5-year-old girl presented with a big painless mass, sized 24 × 37 × 35 cm, in her lower left limb. MRI revealed a huge heterogeneous mass splaying from the left distal femur to the calcaneal region without bony erosion but compressing the arteries and causing bowing of the left tibia and fibula bones. The difficulty was to determine the best course of action taken which would either be limb salvation or amputation. Read More

    Gemcitabine-Induced Radiation Recall Myositis: Case Report and Review of the Literature.
    Case Rep Oncol 2018 Jan-Apr;11(1):168-178. Epub 2018 Mar 27.
    Division of Radiation Oncology, Mayo Clinic, Rochester, Minnesota, USA.
    Gemcitabine-induced radiation recall (GIRR) is a phenomenon wherein the administration of gemcitabine induces an inflammatory reaction within an area of prior radiation. We present the case of a 39-year-old female patient with metastatic breast cancer who experienced GIRR myositis 3 months following postoperative radiotherapy, with additional potential paraspinal myositis following ablative radiotherapy to the thoracic spine. A review of previously published cases of GIRR myositis was performed. Read More

    Fluorescent Light-Guided Cystoscopy with 5-ALA Aids in Accurate Surgical Margin Detection for TURBO: A Case Report.
    Case Rep Oncol 2018 Jan-Apr;11(1):164-167. Epub 2018 Mar 15.
    Departments of Urology and Renal Transplantation, Yokohama City University Medical Center, Yokohama, Japan.
    Recent studies have revealed that transurethral resection in one piece (TURBO) has several benefits over standard transurethral resection of bladder tumor (TUR-Bt), including a higher rate of containing the bladder muscle tissue and single-block resection. Five-aminolevulinic acid (5-ALA) was approved for the detection of bladder tumor treated with TUR-Bt. A 71-year-old male patient who received right nephroureterectomy developed bladder tumor recurrence on routine cystoscopy follow-up. Read More

    The Use of a Metal Stent in the Treatment of Ureteral Stricture in a Patient Who Had Undergone Radical Cystectomy with the Creation of an Ileal Conduit.
    Case Rep Oncol 2018 Jan-Apr;11(1):159-163. Epub 2018 Mar 15.
    Departments of Urology and Renal Transplantation, Yokohama City University Medical Center, Yokohama, Japan.
    Approximately 9.2% of patients who undergo radical cystectomy are reported to develop ureteral stricture as a result of both benign and malignant conditions. A metallic stent is a continuous, unfenestrated all-metal double-pigtail ureteric stent with no end or side holes. Read More

    Non-Gestational Choriocarcinoma with Widespread Metastases Presenting with Type 1 Respiratory Failure in a 39-Year-Old Female: Case Report and Review of the Literature.
    Case Rep Oncol 2018 Jan-Apr;11(1):151-158. Epub 2018 Mar 14.
    Royal United Hospital, Bath, United Kingdom.
    Introduction: Non-gestational choriocarcinoma (NGCC) is an extremely rare cancer. We report a case presenting in extremis.

    Case Report: A 39-year-old woman presented with type 1 respiratory failure with a 1-month history of breathlessness. Read More

    Hyperprogressive Disease in the Irradiation Field after a Single Dose of Nivolumab for Gastric Cancer: A Case Report.
    Case Rep Oncol 2018 Jan-Apr;11(1):143-150. Epub 2018 Mar 7.
    Department of Medical Oncology, Kobe City Hospital Organization, Kobe City Medical Center General Hospital, Kobe, Japan.
    Following the ATTRACTION-2 study, nivolumab was approved for advanced gastric cancer in Japan. However, pseudoprogression and hyperprogressive disease have been reported in patients treated with immune checkpoint inhibitors. We report a patient with gastric cancer who received nivolumab after radiotherapy only to experience rapid progression within the irradiation field after the first immunotherapy session. Read More

    A 58-Year-Old Woman with Left-Sided Weakness and a History of a Pediatric Brain Tumor: A Case Report.
    Case Rep Oncol 2018 Jan-Apr;11(1):131-137. Epub 2018 Mar 2.
    Division of Radiation Oncology, Allegheny Health Network, Pittsburgh, Pennsylvania, USA.
    Background: An uncommon but well-established complication of cranial irradiation is secondary neoplasm. This case presentation documents a radiation-induced malignant glioma 55 years after being diagnosed with "cerebral sarcoma," now defined as atypical meningioma. This not only represents the longest reported latency period for a patient initially receiving over 30 Gy, but also provides a valuable historical perspective of neuro-oncology. Read More

    Successful Surgical Resection following Bronchial Artery Embolization in a Case of Lung Cancer Complicated with Massive Hemoptysis.
    Case Rep Oncol 2018 Jan-Apr;11(1):125-130. Epub 2018 Feb 28.
    Division of Haematology, Respiratory Medicine and Oncology, Department of Internal Medicine, Faculty of Medicine, Saga University, Saga, Japan.
    Hemoptysis is sometimes observed in lung cancer patients and can be life-threatening. We present a case with severe hemoptysis that was resolved by bronchial artery embolization (BAE) followed by surgery. The presence of necrotic tissue in the majority of the resected tumor and only few cancer cells was presumed to be from loss of bronchial artery blood flow. Read More

    Severe Adverse Reaction to Vemurafenib in a Pregnant Woman with Metastatic Melanoma.
    Case Rep Oncol 2018 Jan-Apr;11(1):119-124. Epub 2018 Feb 15.
    Department of Obstetrics and Gynaecology, Academic Medical Center, Amsterdam, The Netherlands.
    Targeted therapies have drastically changed the management of metastatic melanoma and have shown encouraging results on tumour progression but are also known for their high rates of adverse reactions. In general, targeted therapies are contraindicated during pregnancy due to concerns about teratogenesis. For the BRAF V600 inhibitor vemurafenib, the available literature about the effects on human pregnancy is limited to a single case report. Read More

    Intensity-Modulated Radiotherapy Triggers Onset of Bullous Pemphigoid in a Patient with Advanced Melanoma Treated with Nivolumab.
    Case Rep Oncol 2018 Jan-Apr;11(1):114-118. Epub 2018 Feb 15.
    Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai, Japan.
    Since the efficacy of ipilimumab on nivolumab-resistant advanced melanoma is extremely low, additional supportive therapy for anti-PD-1 antibody therapy-resistant advanced melanoma is needed. Although several supportive therapies that enhance the antitumor immune response of anti-PD-1 antibodies have already been reported, unexpected immune-related adverse events were detected at the same time. In this report, we describe a patient with advanced melanoma treated with nivolumab followed by intensity-modulated radiotherapy, which might have triggered bullous pemphigoid (BP). Read More

    Concomitant Non-Small Cell Lung Cancer and Hairy Cell Leukemia in a Patient Harboring BRAF-V600E Mutation in Both Tissues: A Case Report.
    Case Rep Oncol 2018 Jan-Apr;11(1):109-113. Epub 2018 Feb 14.
    Klinik für Onkologie, Hämatologie und Palliativmedizin, Marien Hospital Düsseldorf, Düsseldorf, Germany.
    The BRAF-V600E mutation has been established as a signature alteration occurring almost universally in hairy cell leukemia. Moreover, it can be detected in a small percentage of patients with non-small cell lung cancer. We report the case of a patient with a metastatic BRAF-V600E-mutated lung adenocarcinoma suffering from concomitant hairy cell leukemia. Read More

    Multiloculated Cavitary Primary Pulmonary Hodgkin Lymphoma: Case Series.
    Case Rep Oncol 2018 Jan-Apr;11(1):90-97. Epub 2018 Feb 15.
    General Surgery Department, King Fahad Military Medical Complex, Dhahran, Saudi Arabia.
    Primary pulmonary Hodgkin lymphoma (PPHL) is very rare and typically involves the superior portion of the lung. Pulmonary involvement is observed in 15-40% of Hodgkin lymphoma patients. Three such patients who presented with an unusual form of PPHL in radiological studies, i. Read More

    Surgical Treatment following Chemo-Targeted Therapy with Bevacizumab for Lung Metastasis from Colorectal Carcinoma: Analysis of Safety and Histological Therapeutic Effects in Patients Treated at a Single Institution.
    Case Rep Oncol 2018 Jan-Apr;11(1):98-108. Epub 2018 Feb 9.
    aDepartment of Thoracic Surgery, Osaka International Cancer Institute (formerly Osaka Medical Cancer Center for Cancer and Cardiovascular Diseases), Osaka, Japan.
    Background: Recently, therapeutic strategies for a metastasectomy from colorectal carcinoma after chemo-targeted therapy with bevacizumab have been presented, with which some uncommon but serious adverse events have been reported. However, only few reports have investigated the safety of lung resection after such therapy or the histological effects. We retrospectively analyzed the both of them at our institute. Read More

    Long-Lasting Response to Trabectedin in a Patient with Metastatic Uterine Leiomyosarcoma: A Case Report.
    Case Rep Oncol 2018 Jan-Apr;11(1):81-89. Epub 2018 Feb 9.
    aDepartment of Gynecology and Obstetrics, St. Elisabethenkrankenhaus, Frankfurt am Main, Germany.
    Background: Uterine leiomyosarcoma (uLMS) is a rare tumor that accounts for 1% of all uterine malignancies. In spite of adequate surgical resection of uLMS, even in the early stage, patients remain at high risk for local and distant recurrence. Therefore, the treatment of advanced uLMS represents a considerable challenge. Read More

    A Case of Squamous Cell Carcinoma of Unknown Primary that Responded to the Multi-Tyrosine Kinase Inhibitor Lenvatinib.
    Case Rep Oncol 2018 Jan-Apr;11(1):75-80. Epub 2018 Feb 9.
    aDepartment of Medical Oncology, Fukushima Medical University, Fukushima, Japan.
    Lenvatinib is an oral tyrosine kinase inhibitor of vascular endothelial growth factor receptors 1, 2, and 3, fibroblast growth factor receptors 1 through 4, as well as platelet-derived growth factor receptor α, RET, and KIT. At present, lenvatinib is used in the treatment of thyroid cancer and renal cell carcinoma. We herein report a case of a 67-year-old patient with squamous cell carcinoma of unknown primary who was effectively treated with lenvatinib. Read More

    CSF-ctDNA SMSEQ Analysis to Tailor the Treatment of a Patient with Brain Metastases: A Case Report.
    Case Rep Oncol 2018 Jan-Apr;11(1):68-74. Epub 2018 Feb 1.
    eCellMax Inc., Sunnyvale, California, USA.
    Brain metastases are the most common neurological complications of adult cancers, accounting for more than half of brain tumors. The incidence of brain metastases may be increasing due to improved detection of small lesions by advanced imaging technologies. Given the fast evolution of targeted and immunotherapy regimens, it is essential to serially assess brain malignancies during the disease course for disease monitoring and tailoring of the therapeutic management. Read More

    Acute Lymphoblastic Leukemia Presenting as Fanconi Syndrome.
    Case Rep Oncol 2018 Jan-Apr;11(1):63-67. Epub 2018 Feb 1.
    Department of Pediatrics, Wakayama Medical University, Wakayama City, Japan.
    Acute lymphoblastic leukemia (ALL) presenting as Fanconi syndrome (FS) is extremely rare. Here, we report a case of ALL presenting as bilateral nephromegaly following FS. A 2-year-old girl was unexpectedly diagnosed with bilateral nephromegaly. Read More

    Rosai-Dorfman Disease Complicated by Autoimmune Hemolytic Anemia in a Child: A Case Report and Review of the Literature.
    Case Rep Oncol 2018 Jan-Apr;11(1):55-62. Epub 2018 Jan 19.
    King Fahad Hospital of the University, Faculty of Medicine, Imam Abdulrahman bin Faisal University, AL-Khobar, Saudi Arabia.
    Rosai-Dorfman disease is a rare histiocytic proliferative disorder that commonly presents with a massive lymphadenopathy and a variety of constitutional symptoms. Severe hemolytic anemia is an infrequent complication of this disease. Although the etiology of the condition is unknown, infectious agents including viruses have been implicated. Read More

    Successful Salvage Chemotherapy with Streptozocin in a Patient with Mediastinal Atypical Carcinoid Tumor Who Had Relapsed after Various Prior Therapies.
    Case Rep Oncol 2018 Jan-Apr;11(1):49-54. Epub 2018 Jan 19.
    aDepartment of Comprehensive Cancer Therapy, Shinshu University School of Medicine, Matsumoto, Japan.
    Pulmonary neuroendocrine tumors are rare, and there have been very few reports regarding optimal chemotherapeutic regimens. Two molecular targeted agents, everolimus and sunitinib, have recently been shown to provide an additional treatment benefit for pulmonary neuroendocrine tumors. However, little information is available regarding the usefulness of streptozocin chemotherapy. Read More

    Beneficial Treatment Management with Trifluridine/Tipiracil in a Patient with Metastatic Colorectal Cancer and Pronounced Hematological Event History during Previous Treatments.
    Case Rep Oncol 2018 Jan-Apr;11(1):43-48. Epub 2018 Jan 17.
    aMVZ für Hämatologie und Onkologie, Ulm, Germany.
    Trifluridine/tipiracil (FTD/TPI) significantly improves overall survival in patients with metastatic colorectal cancer (mCRC). The most common treatment-related event (grade ≥3) was hematological toxicity. We here report long-term disease-stabilizing FTD/TPI treatment of an mCRC patient (KRAS wild-type, ECOG performance status 1 at baseline and at the end of FTD/TPI therapy) with multifocal synchronous metastases and a longstanding history of extensive hematological events during previous treatments. Read More

    Metastatic Small Cell Carcinoma of the Breast from Cancer of the Uterine Cervix: A Case Report.
    Case Rep Oncol 2018 Jan-Apr;11(1):38-42. Epub 2018 Jan 17.
    Department of Surgery, College of Medicine, Dongguk University, Goyang, Republic of Korea.
    We report here on a case of 51-year-old woman with metastatic small cell carcinoma of the breast that came from her cancer of the uterine cervix. She underwent radical hysterectomy with bilateral salpingo-oophorectomy due to small cell carcinoma of the uterine cervix, and adjuvant radiotherapy was administered to the pelvis. Breast metastasis with a palpable mass then occurred 3 months after the primary surgery. Read More

    Tiny Obturator Node Metastasis from Prostate Cancer Not Shown by FDG-PET/CT, CT, or MRI Detected by C-Choline PET/CT.
    Case Rep Oncol 2018 Jan-Apr;11(1):33-37. Epub 2018 Jan 16.
    cDepartment of Radiology, Hyogo College of Medicine, Nishinomiya, Japan.
    We report a 65-year-old male with histopathologically proven prostate cancer and multiple pelvic node metastases using a robotic-assisted radical prostatectomy procedure plus extended pelvic lymph node dissection. Positron emission tomography (PET) scan findings demonstrated a moderate accumulation of C-choline in a metastatic left obturator node sized 8 × 8 mm, though only a faint uptake of fluorodeoxyglucose (FDG) was noted. C-choline PET/computed tomography (CT) may be useful for the diagnosis of a tiny metastatic lymph node not demonstrated by CT, magnetic resonance imaging, or FDG-PET/CT and to determine the need for an extended pelvic lymph node dissection. Read More

    Successful Treatment of Erythrodermic Mycosis Fungoides with Mogamulizumab Followed by Etoposide Monotherapy.
    Case Rep Oncol 2018 Jan-Apr;11(1):29-32. Epub 2018 Jan 16.
    Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai, Japan.
    Mogamulizumab induces cytotoxicity against CCR4+ lymphoma cells by antibody-dependent cell-mediated cytotoxicity in advanced cutaneous T-cell lymphoma patients. Since the efficacy of mogamulizumab in mycosis fungoides (28.6%) is lower than that in Sézary syndrome (47. Read More

    Metastatic Intimal Sarcoma of the Pulmonary Artery Sensitive to Carboplatin-Vinorelbine Chemotherapy: Case Report and Literature Review.
    Case Rep Oncol 2018 Jan-Apr;11(1):21-28. Epub 2018 Jan 5.
    aDepartment of Medical Oncology, Centre de Recherche en Cancérologie de Marseille (CRCM), Institut Paoli-Calmettes, Marseille, France.
    Pulmonary artery intimal sarcoma (PAIS) is a very rare tumour with a very poor prognosis. In advanced stages, chemotherapy and radiotherapy are poorly efficient, and no standard chemotherapy guideline is currently available. Here, we report on a 37-year-old woman with PAIS initially treated with surgical resection who developed metastatic relapse refractory to anthracycline-based chemotherapy, then trabectedin, then pazopanib. Read More

    Successful Treatment of Refractory Squamous Cell Cancer of the Head and Neck with Nivolumab and Ipilimumab.
    Case Rep Oncol 2018 Jan-Apr;11(1):17-20. Epub 2018 Jan 4.
    aDepartment of Internal Medicine 3, University Hospital Bonn, Bonn, Germany.
    Treatment options for patients with platinum-refractory, recurrent, metastatic head and neck squamous cell carcinoma (HNSCC) are limited, and prognosis is poor. Nivolumab (Opdivo) has been approved by the US Food and Drug Administration (FDA) for the treatment of patients with recurrent or metastatic HNSCC who have disease progression on or after platinum-based therapy. Recently, in patients with metastatic malignant melanoma a significant improvement of outcome and response was achieved with the combination of ipilimumab (CTLA4 antibody) and the programmed death (PD)-1 inhibitor nivolumab compared with monotherapy. Read More

    A Patient with Advanced Gastric Cancer Who Achieved a Long-Term Prognosis by Early Diagnosis of Sister Mary Joseph's Nodule.
    Case Rep Oncol 2018 Jan-Apr;11(1):11-16. Epub 2018 Jan 4.
    aDivision of Medical Oncology, Department of Internal Medicine, Teikyo University School of Medicine, Tokyo, Japan.
    The patient was a 66-year-old woman. An induration of approximately 15 mm in size that accompanied redness was palpable in the umbilical fossa. She did not respond to 1-month antibiotic treatment provided by the previous physician. Read More

    Vesicoenteric Fistula Arising from an Adenocarcinoma of Ectopic Pancreatic Tissue in a Meckel Diverticulum.
    Case Rep Oncol 2018 Jan-Apr;11(1):6-10. Epub 2018 Jan 4.
    aDepartment of Urology, Kyorin University School of Medicine, Mitaka, Japan.
    We report a case of a vesicoenteric fistula arising from an adenocarcinoma of ectopic pancreatic tissue in a Meckel diverticulum in a 58-year-old man. The patient suffered from refractory micturition pain and increased urinary frequency. Computerized tomography with a contrast agent showed a ring-shaped enhanced mass near the dome of the urinary bladder. Read More

    Successful Treatment of Nivolumab-Resistant Multiple In-Transit Melanomas with Ipilimumab and Topical Imiquimod.
    Case Rep Oncol 2018 Jan-Apr;11(1):1-5. Epub 2018 Jan 4.
    Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai, Japan.
    Simultaneous or sequential, planned administration of ipilimumab could significantly enhance the antitumor effects of nivolumab in advanced melanoma patients. On the other hand, the efficacy of ipilimumab for nivolumab-resistant advanced melanoma is extremely poor. Therefore, additional supportive therapy for anti-PD-1 antibody therapy-resistant advanced melanoma has been widely investigated. Read More

    Lactic Acidosis in Prostate Cancer: Consider the Warburg Effect.
    Case Rep Oncol 2017 Sep-Dec;10(3):1085-1091. Epub 2017 Nov 28.
    Department of Internal Medicine, OLVG West Amsterdam, Amsterdam, The Netherlands.
    Lactic acidosis is a commonly observed clinical condition that is associated with a poor prognosis, especially in malignancies. We describe a case of an 81-year-old patient who presented with symptoms of tachypnea and general discomfort. Arterial blood gas analysis showed a high anion gap acidosis with a lactate level of 9. Read More

    Multiple Tumor Induction after Treatment of Temporal Arteritis with Prednisone.
    Case Rep Oncol 2017 Sep-Dec;10(3):1076-1084. Epub 2017 Nov 28.
    A 74-year-old female was diagnosed with the autoimmune inflammatory disease temporal arteritis and treated with high and low doses of prednisone over a period of 6 years. During that time, she developed cancers of the lung and colon as well as a soft tumor mass on lumbar vertebrate L3. She also experienced a series of debilitating and disabling symptoms while on prednisone treatment. Read More

    Pulmonary Sarcoidosis Activation following Neoadjuvant Pembrolizumab plus Chemotherapy Combination Therapy in a Patient with Non-Small Cell Lung Cancer: A Case Report.
    Case Rep Oncol 2017 Sep-Dec;10(3):1070-1075. Epub 2017 Nov 27.
    Division of Hematology and Oncology, Department of Internal Medicine, American University of Beirut Medical Center, Beirut, Lebanon.
    Background: Pembrolizumab is a humanized monoclonal antibody which serves to enhance the antitumor immune response by targeting programmed cell death 1 receptor. The use of pembrolizumab plus carboplatin/pemetrexed combination therapy results in improvement in overall survival and progression-free survival rates for non-small cell lung cancer (NSCLC) patients as compared to chemotherapy alone. However, numerous immune-mediated toxicities of pembrolizumab have been reported. Read More

    A Case of Lung Adenocarcinoma with Marked Improvement of Pulmonary Lymphangitic Carcinomatosis by Adding Bevacizumab to Cisplatin and Pemetrexed.
    Case Rep Oncol 2017 Sep-Dec;10(3):1065-1069. Epub 2017 Nov 27.
    Division of Medical Oncology, Department of Internal Medicine, Teikyo University School of Medicine, Tokyo, Japan.
    A 40-year-old man with a diagnosis of lung adenocarcinoma (cT4N3M1c, stage IVB) experienced worsening of lymphangitic carcinomatosis in the right lung and right pleural effusion after receiving 1 cycle of first-line chemotherapy consisting of cisplatin and pemetrexed. Bevacizumab was thus added from the second cycle of the cisplatin-pemetrexed regimen, leading to a marked improvement in pulmonary lymphangitic carcinomatosis and a decrease in pleural effusion. Subsequently, maintenance therapy consisting of pemetrexed and bevacizumab was continued, successfully leading to long-term progression-free survival. Read More

    Metastatic Urothelial Carcinoma with Glandular Differentiation That Confirmed the Response by Autopsy Specimen to Second-Line mFOLFOX6 (Fluorouracil, Oxaliplatin, and Leucovorin) plus Bevacizumab Chemotherapy.
    Case Rep Oncol 2017 Sep-Dec;10(3):1057-1064. Epub 2017 Nov 27.
    Department of Nephro-urology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.
    The prognostic significance of glandular differentiation in urothelial carcinoma (UC) is controversial, and thus far there is no established treatment strategy against metastasis of glandular component. We describe here a case of metastatic UC with glandular differentiation that had histological disappearance of adenocarcinoma components at autopsy after sequential chemotherapy with S-1 and cisplatin (CDDP) and with mFOLFOX6 (fluorouracil, oxaliplatin, and leucovorin) plus bevacizumab (mFOLFOX6+Bev). A 62-year-old Asian male was diagnosed with invasive UC with glandular differentiation (T2N0M0) by radical cystectomy and ileal conduit, and careful follow-up observation was made. Read More

    Synchronous Primary Renal Cell Carcinoma and Pancreatic Ductal Adenocarcinoma: Case Report and Literature Review.
    Case Rep Oncol 2017 Sep-Dec;10(3):1050-1056. Epub 2017 Nov 27.
    Department of Medical Oncology, Mohamed V Military University Hospital, Rabat, Morocco.
    Synchronous primary cancers involving the pancreas and kidney are extremely rare and poorly documented. We report the first case of this association treated with chemotherapy and tyrosine kinase inhibitor. A 70-year-old woman presented with a 2-month history of epigastric pain with weight loss of 12 kg. Read More

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