1,375 results match your criteria Case reports in oncology[Journal]


Primary Adrenal Insufficiency during Immune Checkpoint Inhibitor Treatment: Case Reports and Review of the Literature.

Case Rep Oncol 2020 May-Aug;13(2):621-626. Epub 2020 Jun 9.

Medical Oncology Service Bradford Hill, Santiago de Chile, Chile.

As the indications and clinical use of immune checkpoint inhibitors increase, it is expected that we will face some of their less frequently reported complications. Primary adrenal insufficiency is one of them, and given its unspecific symptoms and potentially serious consequences, it is important to have a high degree of clinical suspicion. We present 3 cases and a review of the literature concerning its main clinical characteristics, diagnostics, and management. Read More

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http://dx.doi.org/10.1159/000507652DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7315192PMC

Proximal Gastrectomy in a Case of Giant Gastric Liposarcoma and a 5-Year Follow-Up.

Case Rep Oncol 2020 May-Aug;13(2):617-620. Epub 2020 Jun 4.

Department of Field Surgery, Faculty of Military Health Science, University of Defence, Hradec Králové, Czechia.

Even though liposarcomas account for 10-20% of all mesenchymal malignancies, they are extremely rarely located in the stomach. We report the case of a female patient with gastric liposarcoma. CT revealed a giant hypoechogenic tumour subcardially on the posterior gastric wall. Read More

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http://dx.doi.org/10.1159/000507477DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7315206PMC

Primary Intraosseous Squamous Cell Carcinoma Arising from a Dentigerous Cyst of the Maxillary Wisdom Tooth.

Case Rep Oncol 2020 May-Aug;13(2):611-616. Epub 2020 Jun 4.

International Exchange Center, Showa University, Tokyo, Japan.

The World Health Organization defines primary intraosseous squamous cell carcinoma (PIOSCC) as a squamous cell carcinoma (SCC) arising primarily within the jaws and having no connection with the oral mucosa. Here, we report a case of PIOSCC in which it was difficult to differentiate the condition from pericoronitis of an impacted maxillary wisdom tooth. The patient was a 27-year-old pregnant woman with a pain in the right maxillary wisdom tooth. Read More

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http://dx.doi.org/10.1159/000507478DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7315222PMC

Extreme Levels of Platelet Count in Essential Thrombocythemia: Management and Outcome, Report of Two Cases.

Case Rep Oncol 2020 May-Aug;13(2):606-610. Epub 2020 Jun 4.

National Center for Cancer Care and Research, Department of Oncology, Hematology and BMT Section, Hamad Medical Corporation, Doha, Qatar.

Myeloproliferative neoplasms including essential thrombocythemia (ET) is usually caused by somatic mutations in multiple genes, including the JAK2 (most frequently), CALR gene, and MPL. In rare cases, the disease is caused by other mutations such as THPO or TET2 gene; however, around 10-15% with ET might have triple-negative mutations. Here we present 2 cases of ET who were asymptomatic on diagnoses, but found to have extremely high platelet counts as never reported earlier. Read More

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http://dx.doi.org/10.1159/000507363DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7315211PMC

Dramatic Response of Pulmonary Sarcomatoid Carcinoma to Nivolumab Combined with Anlotinib: A Case Report.

Authors:
Caibao Jin Bin Yang

Case Rep Oncol 2020 May-Aug;13(2):601-605. Epub 2020 Jun 4.

Department of Thoracic Oncology, Hubei Cancer Hospital, Wuhan, China.

Pulmonary sarcomatoid carcinoma (PSC) is a rare subtype of non-small-cell lung cancer, which is resistant to the conventional chemotherapy and radiotherapy with a poor prognosis. Limited case reports have showed good response to the immunotherapy in PSC patients with high PD-L1 expression generally. Herein, we report a case of rapid recurrence of PSC during postoperative adjuvant chemotherapy in a 62-year-old male ex-smoker. Read More

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http://dx.doi.org/10.1159/000507568DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7315215PMC

and Concomitant Mutations in a Patient with Metastatic Colon Adenocarcinoma: An Interesting Case Report.

Case Rep Oncol 2020 May-Aug;13(2):595-600. Epub 2020 Jun 4.

Unità di Oncologia Medica, Ospedale S.G. Moscati, Taranto, Italy.

A 68-year-old female patient with tenesmus and blood in the stool was admitted to the S.G. Moscati Hospital of Taranto. Read More

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http://dx.doi.org/10.1159/000507882DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7315173PMC

Cerebral Venous Thrombosis in a Patient with Immune Thrombocytopenia, an Apparent Paradox.

Case Rep Oncol 2020 May-Aug;13(2):588-594. Epub 2020 Jun 4.

Department of Medical Oncology, National Centre for Cancer Care and Research, Hamad Medical Corporation, Doha, Qatar.

We present a paradoxical case of immune thrombocytopenia (ITP) that presented with cerebral venous thrombosis. A 39-year-old female patient diagnosed with chronic ITP, who failed treatment on multiple-line agents, was started on eltrombopag (thrombopoietin receptor agonist), which she was not compliant to. The patient later developed extensive cerebral venous thrombosis, along with venous infarcts, and intracranial and subarachnoid hemorrhage. Read More

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http://dx.doi.org/10.1159/000507389DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7315189PMC

Thyroiditis: A Rare Manifestation of Enasidenib-Induced Differentiation Syndrome.

Case Rep Oncol 2020 May-Aug;13(2):583-587. Epub 2020 May 27.

Division of Hematology/Oncology, Georgia Cancer Center, Augusta University, Augusta, Georgia, USA.

Enasidenib is an FDA-approved isocitrate dehydrogenase 2 (IDH2) inhibitor, which is used in the treatment of acute myeloid leukemia (AML). We present a case of AML with an IDH2 mutation treated with a regimen of enasidenib and 5-azacitidine, where thyroiditis was noted to be a part of differentiation syndrome. The patient is a 77-year-old woman with IDH2-mutated AML who had initially been started on 100 mg of enasidenib and then presented with dyspnea and was diagnosed with pleural effusion - a common presentation with enasidenib - but was also noted to have thyroiditis. Read More

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http://dx.doi.org/10.1159/000507613DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7275196PMC

Parathyroid Adenoma as a Rare Cause of Persistent Hypercalcemia in a Female with Polycythemia Vera.

Case Rep Oncol 2020 May-Aug;13(2):578-582. Epub 2020 May 26.

Hamad Medical Corporation, Doha, Qatar.

Polycythemia vera is one of the myeloproliferative neoplasms that is distinguished by the uncontrolled production of blood cells and an increased red cell mass due to acquired mutation. It has many complications and it might increase the risk of other tumors. However, it does not cause hypercalcemia and is rarely associated with parathyroid adenoma. Read More

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http://dx.doi.org/10.1159/000507362DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7275195PMC

Confirmed Coronavirus Disease-19 (COVID-19) in a Male with Chronic Myeloid Leukemia Complicated by Febrile Neutropenia and Acute Respiratory Distress Syndrome.

Case Rep Oncol 2020 May-Aug;13(2):569-577. Epub 2020 May 19.

Hamad Medical Corporation, Doha, Qatar.

Coronavirus disease-19 is a respiratory viral disease that commonly presents with mild symptoms. However, it can cause serious complications such as acute respiratory disease, especially in patients with comorbidities. As it is a new disease, the full picture of the disease and its complications are not yet fully understood. Read More

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http://dx.doi.org/10.1159/000508378DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7275193PMC

Synchronous and Metachronous Metastatic Breast Cancer, with Different Histology and Opposite Immunophenotype, Treated with Combination of Chemotherapy, Anti-Her2, and Endocrine Therapy: A Case Report.

Case Rep Oncol 2020 May-Aug;13(2):544-549. Epub 2020 May 13.

Medical Oncology Unit A Policlinico Umberto I, University of Rome "Sapienza", Rome, Italy.

In the case of our patient, the synergic action of endocrine therapy and chemotherapy plus dual anti-HER2 combination allowed a complete disease control. Therapy should be scheduled by considering the two cancers as individual entities. The approach to breast cancer is changing from being considered a singular disease to a multiform one, according to current research focused on biological markers such as HER2, ERs, and PRs, with important implications in clinical, prognostic, and therapeutic features. Read More

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http://dx.doi.org/10.1159/000507433DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7275194PMC

Crystalline Lens Resorption Caused by Ciliary Body Melanoma.

Case Rep Oncol 2020 May-Aug;13(2):497-500. Epub 2020 May 12.

California Pacific Medical Center, San Francisco, California, USA.

We report a case of a 51-year-old Caucasian female who presented with a ciliary body melanoma of the right eye leading to focal resorption of the crystalline lens and inducing posterior subcapsular cataract. She underwent successful enucleation, and histopathology demonstrated a ciliary body melanoma with a predominance of epithelioid cells and focal scleral extension. Genetic testing revealed a heterozygous, pathogenic mutation of BAP1 (c. Read More

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http://dx.doi.org/10.1159/000507509DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7275197PMC

Surgical Reconstruction Methods following Radical Excision of Distal Ulna Osteosarcoma in Both Skeletally Mature and Immature Patients.

Case Rep Oncol 2020 May-Aug;13(2):558-568. Epub 2020 May 19.

Department of Pathology and Laboratory Medicine, King Hussein Cancer Center, Amman, Jordan.

The distal ulna has always been considered to be expendable and its removal has been advocated for a variety of post-traumatic degenerative and oncological conditions but recent studies showed that the distal radioulnar joint allows supination and protonation of the forearm and is important to one's grip strength and lifting ability. Several prosthesis models have already been made to replace the mechanical functionality of the distal radioulnar joint. We present two cases of females aged 22 and 12 years, respectively, who presented with wrist pain and swelling without any history of trauma and with terminal degree limitation in wrist movements due to tenderness and swelling. Read More

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http://dx.doi.org/10.1159/000507284DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7265732PMC

Associated Myocarditis: A Predictive Factor for Response?

Case Rep Oncol 2020 May-Aug;13(2):550-557. Epub 2020 May 19.

The Legacy Heritage Oncology Center and Dr. Larry Norton Institute, Soroka Medical Center and Ben-Gurion University, Beer Sheva, Israel.

In the present case report, we aimed to describe 2 cases of myocarditis occurring as serious adverse effects of immune checkpoint inhibitors (ICIs) administered as treatment for metastatic melanoma. We describe 2 female patients: an 81-year-old treated with pembrolizumab and a 55-year-old treated with a combination of nivolumab and ipilimumab. Both patients underwent resection of metastases; while under treatment, both developed myocarditis, most probably as a toxicity from pembrolizumab and nivolumab plus Ipilimumab, respectively. Read More

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http://dx.doi.org/10.1159/000507278DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7265708PMC

Signet Ring Cell Carcinoma Mimicking Gastric Gastrointestinal Stromal Tumor: A Case Report.

Authors:
Jin Lee Sung Jin Oh

Case Rep Oncol 2020 May-Aug;13(2):538-543. Epub 2020 May 13.

Department of Surgery, Inje University Haeundae Paik Hospital, Inje University College of Medicine, Busan, Republic of Korea.

The presentation of submucosal gastric cancer, especially signet ring cell carcinoma, is rare. The submucosal tumor (SMT) is covered with normal mucosa, and confirmation is difficult through endoscopic biopsy; thus, histologic diagnosis is important to determine the appropriate treatment method. Here, we report a case of gastric signet ring cell carcinoma mimicking gastrointestinal stromal tumor (GIST). Read More

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http://dx.doi.org/10.1159/000506448DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7265698PMC

Management of a 75-Year-Old Lady with Refractory Chronic Myelogenous Leukemia.

Case Rep Oncol 2020 May-Aug;13(2):534-537. Epub 2020 May 13.

Medical Oncology, Augusta University, Augusta, Georgia, USA.

Chronic myelogenous leukemia (CML) is a hematopoietic disorder caused by the BCR/ABL gene or Philadelphia chromosome. The first Food and Drug Administration (FDA)-approved tyrosine kinase inhibitor for treatment of CML was imatinib in 2001. Since then, multiple therapies, such as nilotinib, dasatinib, bosutinib, and, more recently, ponatinib, have made their way as viable treatment options for first-line and secondary therapies. Read More

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http://dx.doi.org/10.1159/000506895DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7265745PMC

Reducing Malignant Ascites and Long-Term Survival in a Patient with Recurrent Gastric Cancer Treated with a Combination of Docetaxel and Mistletoe Extract.

Authors:
Sung Jin Oh

Case Rep Oncol 2020 May-Aug;13(2):528-533. Epub 2020 May 12.

Department of Surgery, Haeundae Paik Hospital, Inje University College of Medicine, Busan, Republic of Korea.

Recurrent gastric cancer with peritoneal seeding is associated with poor overall survival. A 71-year-old man with advanced gastric cancer underwent radical total gastrectomy (stage IIIb, T4b N1 M0). Abdomino-pelvic computed tomography performed 7 months after surgery revealed increased ascites with enhanced peritoneal thickening. Read More

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http://dx.doi.org/10.1159/000507282DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7265700PMC

Rechallenge with Lenvatinib after Refractoriness to Initial Lenvatinib Followed by Sorafenib in a Patient with Metastatic Papillary Thyroid Carcinoma.

Case Rep Oncol 2020 May-Aug;13(2):522-527. Epub 2020 May 12.

Division of Gastrointestinal Oncology, Shizuoka Cancer Center, Shizuoka, Japan.

Two tyrosine kinase inhibitors, lenvatinib and sorafenib, are available systemic therapies for patients with metastatic differentiated thyroid carcinoma. However, the treatment options for carcinoma refractory to both lenvatinib and sorafenib are limited. Here, we present a case of metastatic papillary thyroid carcinoma that showed resensitization to rechallenge with lenvatinib. Read More

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http://dx.doi.org/10.1159/000507344DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7265699PMC

Complete Superior and Inferior Vena Cava Obstruction Associated with Systemic-to-Pulmonary Venous Shunts in a Young Female with Heterozygous Prothrombin G20210A Gene Mutation.

Case Rep Oncol 2020 May-Aug;13(2):515-521. Epub 2020 May 12.

Department of Medical Oncology, Hematology Section, National Center for Cancer Care and Research, Hamad Medical Corporation, Doha, Qatar.

Complete superior vena cava (SVC) and inferior vena cava (IVC) obstruction is not uncommon and most commonly associated with malignancy. The risk increases in patients with central lines and hypercoagulable states such as with malignancy, thrombophilia, or use of oral contraceptive pills. According to our knowledge, complete SVC and IVC obstruction associated with systemic-to-pulmonary venous shunts in patients with prothrombin G20210A gene mutation has not been reported in the literature. Read More

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http://dx.doi.org/10.1159/000507283DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7265738PMC

Hemophagocytic Lymphohistiocytosis Secondary to PD-1 and IDO Inhibition in a Patient with Refractory Glioblastoma.

Case Rep Oncol 2020 May-Aug;13(2):508-514. Epub 2020 May 12.

Department of Oncology, The Johns Hopkins University School of Medicine and The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland, USA.

Immune checkpoint inhibition (ICI)-based approaches have transformed the treatment landscape of numerous solid tumors. Glioblastoma (GBM) is an aggressive and almost universally fatal disease which is in need of novel treatment options, and combinations of immune checkpoint inhibitors, including dual agent therapy, are starting to be explored in refractory GBM. Growing adoption of ICI-based approaches in solid tumors has been met with improved understanding of immune-related adverse events (IRAEs), including primary hematologic adverse events. Read More

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http://dx.doi.org/10.1159/000507281DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7265705PMC

Challenges of New Approaches in Metastatic Merkel Cell Carcinoma.

Case Rep Oncol 2020 May-Aug;13(2):501-507. Epub 2020 May 12.

Medical Oncology Department, Instituto Português de Oncologia de Lisboa Francisco Gentil, E.P.E, Lisbon, Portugal.

Merkel cell carcinoma is a rare and aggressive cutaneous tumor, and the use of checkpoint inhibitors immunotherapy is a recent indication in its metastatic setting, both first and second line. However, the widespread use of immunotherapy is associated with an increase of acute and late immune-mediated adverse events. We present a case of an elderly fit patient with metastatic Merkel cell carcinoma treated with pembrolizumab who developed diabetic ketoacidosis, a severe immune-mediated adverse event. Read More

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http://dx.doi.org/10.1159/000507279DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7265742PMC

Consilium Smartphone App for Real-World Electronically Captured Patient-Reported Outcome Monitoring in Cancer Patients Undergoing anti-PD-L1-Directed Treatment.

Case Rep Oncol 2020 May-Aug;13(2):491-496. Epub 2020 May 12.

OnkoZentrum Zürich, Zurich, Switzerland.

Digital patient monitoring gains importance for quality of clinical cancer care. Our case report provides insight into usability and acceptance of a smartphone app for monitoring of electronically captured patient-reported outcomes in patients undergoing immunotherapy. During 3 months, 6 patients with advanced or metastatic PD-L1-positive cancer of the lung, prostate, and bladder who underwent checkpoint immunotherapy were using the Consilium app for standardized and structured electronic reporting of symptoms and therapy side effects. Read More

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http://dx.doi.org/10.1159/000507345DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7265704PMC

Gestational Trophoblastic Neoplasia with Gum Metastasis: A Case Study and Literature Review.

Case Rep Oncol 2020 May-Aug;13(2):485-490. Epub 2020 May 6.

Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.

Gestational trophoblastic neoplasia (GTN) is an uncommon group of pregnancy-related malignancies. Delayed diagnosis is a prognostic factor for worse outcome. GTN is even harder to diagnose if the site of metastasis is uncommon. Read More

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http://dx.doi.org/10.1159/000506329DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7250376PMC

Checkpoint Inhibition Causing Complete Remission of Metastatic Combined Hepatocellular-Cholangiocarcinoma after Hepatic Resection.

Case Rep Oncol 2020 Jan-Apr;13(1):478-484. Epub 2020 Apr 30.

Transplant Institute, Sahlgrenska University Hospital, Gothenburg, Sweden.

Combined hepatocellular-cholangiocarcinoma (CHC) is a rare type of primary liver cancer, speculated to arise from hepatic progenitor cells, and with a worse prognosis than hepatocellular carcinoma (HCC). Serum alpha-fetoprotein (AFP) levels may be one prognostic factor. It has been suggested that checkpoint inhibition might be useful in the treatment of HCC where there is an increased expression of PD-1 and PD-L1 in the microenvironment. Read More

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http://dx.doi.org/10.1159/000507320DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7250374PMC

Severe Demyelinating Neuropathy in an Advanced Melanoma Patient Treated with Nivolumab plus Ipilimumab Combined Therapy.

Case Rep Oncol 2020 Jan-Apr;13(1):474-477. Epub 2020 Apr 30.

Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai, Japan.

Immune checkpoint inhibitors (ICIs) significantly prolong survival in patients with metastatic melanoma but can lead to serious immune-related adverse events. In this report, we described a case of atypical neuropathy caused by nivolumab plus ipilimumab combination therapy before primary tumor resection. In our case, not only demyelinating neuropathy, but also muscle weakness and unilateral facial nerve palsy developed and manifested as severe and diverse symptoms. Read More

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http://dx.doi.org/10.1159/000506976DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7250384PMC

Different Imaging Features of Retroperitoneal Unicentric Castleman's Disease: A Case Report.

Case Rep Oncol 2020 Jan-Apr;13(1):468-473. Epub 2020 Apr 30.

Department of Endocrinology, Hefei Hospital affiliated to Anhui Medical University (The Second People's Hospital of Hefei), Hefei, China.

Castleman's disease is a rare disease which is difficult to diagnose early due to its lack of specific manifestations, and also is easily confused with lymphoma or other solid tumors. Castleman's disease can occur in any part of the body containing lymph nodes and is most common in the chest, followed by the neck, abdomen, and axillae. A 37-year-old woman was admitted to our hospital because of a tumor near the adrenal gland found by computed tomography. Read More

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http://dx.doi.org/10.1159/000507111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7250378PMC

IL-23 Expression in Stewart-Treves Syndrome: Two Case Reports and Immunohistochemical Investigation.

Case Rep Oncol 2020 Jan-Apr;13(1):462-467. Epub 2020 Apr 30.

Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai, Japan.

Stewart-Treves syndrome (STS) is a rare cutaneous lymphangiosarcoma developing from chronic lymph edema as a consequence of radical mastectomy or surgical invasion of the groin for the treatment of cervical or penile cancer. Previous reports suggested possible mechanisms in the development of lymphangiosarcoma that correlate with the immunological background of STS patients. In this report, we described two cases of STS developing in patients who underwent radical dissection for cervical cancer, we employed immunohistochemical staining of IL-23 and IL-17. Read More

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http://dx.doi.org/10.1159/000506975DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7250377PMC

Exceptional Response to Everolimus in a Patient with Metastatic Castrate-Resistant Prostate Cancer Harboring a PTEN Inactivating Mutation.

Case Rep Oncol 2020 Jan-Apr;13(1):456-461. Epub 2020 Apr 27.

Department of Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.

Prostate cancer is among the most common types of cancer in men. Early detection and proper medical intervention is crucial to ensuring successful treatment. Here we describe a patient clinically presenting with castrate-resistant prostate carcinoma. Read More

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http://dx.doi.org/10.1159/000506625DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7204854PMC

A Case of Tyrosine Kinase Inhibitor-Resistant Chronic Myeloid Leukemia, Chronic Phase with ASXL1 Mutation.

Case Rep Oncol 2020 Jan-Apr;13(1):449-455. Epub 2020 Apr 22.

Division of Hematology, Faculty of Medicine, Kagawa University, Kagawa, Japan.

Hematological malignancies, including chronic myeloid leukemia (CML), exhibit mutations; however, the function and molecular mechanism of these mutations remain unclear. was originally identified as tumor suppressor gene, in which loss of function causes myelodysplastic syndrome (MDS). mutations are common and associated with disease progression in myeloid malignancies including MDS, acute myeloid leukemia, and similarly in CML. Read More

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http://dx.doi.org/10.1159/000506452DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7204851PMC

Neutropenic Enterocolitis in the Treatment of Solid Tumors: A Case Report and Review of the Literature.

Case Rep Oncol 2020 Jan-Apr;13(1):442-448. Epub 2020 Apr 22.

Department of Oncology, Fondazione Poliambulanza, Brescia, Italy.

Neutropenic enterocolitis is a clinical condition characterized by inflammation of the colic mucosa, usually the caecum, associated with bowel wall thickening in patients with compromised immune system due to chemotherapy treatments. It can occur as well in other clinical conditions that lead to immunosuppression. Clinically, patients present with abdominal pain, fever, and neutropenia on blood tests. Read More

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http://dx.doi.org/10.1159/000506896DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7204860PMC

Preliminary Presentation of Metastatic Non-Small Cell Carcinoma of the Lung as Atraumatic Avulsion Fracture of the Lesser Trochanter.

Case Rep Oncol 2020 Jan-Apr;13(1):436-441. Epub 2020 Apr 21.

Orthopaedic Department, Queen Elizabeth Hospital, Gateshead, United Kingdom.

Traumatic avulsion fractures of the lesser trochanter are usually seen along with fractures of the proximal femur and with young adolescents involved in high-intensity sporting injuries. Atraumatic isolated lesser trochanter avulsion in adults are most commonly associated with malignancy. We describe a case of a female in her sixties who was previously fit and healthy with no systemic illness and no history of trauma presenting with groin pain. Read More

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http://dx.doi.org/10.1159/000506451DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7204840PMC

Incidental Accumulation of Fluciclovine in Neuroendocrine Tumour in a Patient with Oncological Duplicity.

Case Rep Oncol 2020 Jan-Apr;13(1):431-435. Epub 2020 Apr 21.

Department of Nuclear Medicine and PET/CT, Tomáš Baťa Hospital Zlín, Zlín, Czechia.

18F-fluciclovine is a PET radiopharmaceutical used for the detection of recurrent prostate cancer in adult men after primary curative treatment with suspicion of recurrence based on elevated prostate-specific antigen level. Several incidental uptakes of 18F-fluciclovine in other tumour types have been described in the literature so far - in breast cancer, hepatocellular carcinoma, and malignant melanoma. Our case report presents a patient with oncological duplicity (prostate gland carcinoma and newly diagnosed neuroendocrine tumour) and with accumulation of fluciclovine in pathologically proved neuroendocrine tumour, later imagined also by octreotide SPECT/CT. Read More

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http://dx.doi.org/10.1159/000506829DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7204768PMC

Adrenal Gland and Gastric Malignant Melanoma without Evidence of Skin Lesion Treated with the Oncolytic Virus Rigvir.

Case Rep Oncol 2020 Jan-Apr;13(1):424-430. Epub 2020 Apr 17.

Rigvir, Riga, Latvia.

Adrenal gland melanoma is an extremely rare diagnosis with less than 20 cases reported. The criteria for diagnosing adrenal gland melanoma include involvement of only one adrenal gland, presence of melanin pigment in the histological examination of the tumor tissue, no primary melanoma tumor in any other organ, and no history of resection of pigmented lesions. However, it is complicated to rule out melanoma of unknown primary origin. Read More

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http://dx.doi.org/10.1159/000506978DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7204777PMC

Cowden Syndrome Diagnosed by Bilateral Breast Cancer with Lhermitte-Duclos Disease: A Case Report.

Case Rep Oncol 2020 Jan-Apr;13(1):419-423. Epub 2020 Apr 17.

Department of Breast and Endocrine Surgery, Osaka City University Graduate School of Medicine, Osaka, Japan.

Cowden syndrome is extremely rare and is characterized by multiple hamartomas in various tissues, including the skin, mucous membranes, gastrointestinal tract, breast, thyroid, and brain, and has an increased risk of breast, thyroid, and uterine cancers. Here, we report a case of Cowden syndrome diagnosed following presentation with bilateral breast cancer and provide a discussion of the relevant literature. A 47-year-old woman with a tumor in her right breast was referred to our hospital. Read More

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http://dx.doi.org/10.1159/000506979DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7204884PMC

Procedure of Direct Hepatic Artery Puncture for the Treatment of Hepatocellular Carcinoma: Two Case Reports.

Case Rep Oncol 2020 Jan-Apr;13(1):414-418. Epub 2020 Apr 17.

Department of Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine Graduate School of Medical Science, Kyoto, Japan.

Recently, treatment options for hepatocellular carcinoma (HCC) have expanded due to the development of the tyrosine kinase inhibitor ramucirumab and immune checkpoint inhibitors. Transcatheter arterial chemoembolization is the standard therapy for intermediate-stage HCC; however, in cases with anatomical problems, normal approaches are not possible. In such rare cases, direct hepatic puncture may be considered as an effective therapy and an indispensable treatment. Read More

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http://dx.doi.org/10.1159/000506445DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7204887PMC

Bone Marrow Langerhans Cell Histiocytosis in Association with Kasabach-Merritt Syndrome: The Difficulty of a Differential Diagnosis.

Case Rep Oncol 2020 Jan-Apr;13(1):408-413. Epub 2020 Apr 14.

Department of Internal Medicine II, Professor Doutor Fernando Fonseca Hospital, Amadora, Portugal.

Langerhans cell histiocytosis is a rare haematological disorder with variable clinical findings and a high mortality rate. On the other hand, Kasabach-Merritt syndrome is of rare onset at adult age, requiring the simultaneous presentation of vascular lesion, thrombocytopenia, and consumptive coagulopathy. We present the first reported case of both diseases in a single patient and highlight the difficulties of diagnostic. Read More

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http://dx.doi.org/10.1159/000506539DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7184841PMC

Renal Squamous Cell Carcinoma with Staghorn Calculus.

Case Rep Oncol 2020 Jan-Apr;13(1):403-407. Epub 2020 Apr 9.

Department of Urology, Fujisawa City Hospital, Fujisawa, Japan.

A 70-year-old Japanese woman was referred to our department due to general fatigue and a persistent low fever. We performed percutaneous nephrostomy and administered antibiotics for the pyelonephritis due to her left staghorn calculus. After the infection had been brought under control and her general condition improved, we performed nephrectomy. Read More

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http://dx.doi.org/10.1159/000506675DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7184838PMC

A Case of Solitary Lung Metastasis of Breast Cancer Successfully Treated with Stereotactic Body Radiotherapy after Chemotherapy.

Case Rep Oncol 2020 Jan-Apr;13(1):398-402. Epub 2020 Apr 9.

Department of Surgery, Kishiwada Tokushukai Hospital, Kishiwada-city, Japan.

A 62-year-old woman with triple-negative breast cancer underwent breast-conserving surgery followed by adjuvant chemotherapy and radiotherapy to the breast. The patient developed a solitary lung metastasis at the left hilum 44 months after the operation. The lung metastasis responded partially to capecitabine chemotherapy, but showed regrowth in 7 months. Read More

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http://dx.doi.org/10.1159/000506733DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7184842PMC

Three Curative Pancreatectomies for the Metachronous Appearance of Pancreatic Invasive Ductal Adenocarcinoma.

Case Rep Oncol 2020 Jan-Apr;13(1):392-397. Epub 2020 Apr 9.

Department of Surgery, Shinshu University School of Medicine, Matsumoto City, Japan.

We report a rare case of a patient who underwent 3 successful curative operations for the metachronous appearance of pancreatic cancer. In July 2007, a 54-year-old woman underwent pylorus-preserving pancreaticoduodenectomy. In March 2010, a tumor measuring 9 mm in diameter was detected in the tail of the pancreas on computed tomography (CT) and magnetic resonance imaging. Read More

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http://dx.doi.org/10.1159/000506732DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7184847PMC

Successful Multidisciplinary Treatment for Aggressive Primary Pulmonary Undifferentiated Pleomorphic Sarcoma.

Case Rep Oncol 2020 Jan-Apr;13(1):385-391. Epub 2020 Apr 9.

Department of Chest Surgery, Fukushima Medical University School of Medicine, Fukushima, Japan.

Undifferentiated pleomorphic sarcoma (UPS) was previously known as malignant fibrous histiocytoma (MFH). This sarcoma occurs preferentially in the extremities and retroperitoneal space; primary pulmonary UPS/MFH is rare. We report a 52-year-old woman referred to our hospital with dyspnea and severe cough. Read More

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http://dx.doi.org/10.1159/000506897DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7184791PMC

A Case of Advanced Hepatocellular Carcinoma with Partial Response after Continuous Ramucirumab Treatment beyond Radiological Progression.

Case Rep Oncol 2020 Jan-Apr;13(1):379-384. Epub 2020 Apr 9.

Department of Hepato-Biliary-Pancreatic Surgery, Clinical Research Institute, National Hospital Organization Kyushu Medical Center, Fukuoka, Japan.

A 73-year-old male was initially treated with sorafenib for advanced stage HCC. However, the disease progressed 2 months after starting sorafenib. Progressive disease (PD) was confirmed by radiological examination, which revealed mediastinal and abdominal lymph node metastasis, pulmonary metastasis, and intrahepatic recurrence. Read More

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http://dx.doi.org/10.1159/000506331DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7184828PMC

Complete Response of Recurrent Small Cell Carcinoma of the Uterine Cervix to Paclitaxel, Carboplatin, and Bevacizumab Combination Therapy.

Case Rep Oncol 2020 Jan-Apr;13(1):373-378. Epub 2020 Apr 9.

Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, Nagoya, Japan.

We report a case of recurrent small cell carcinoma of the uterine cervix that showed a complete response to paclitaxel, carboplatin, and bevacizumab (TC + Bev) combination therapy. Small cell carcinoma of the uterine cervix is extremely rare, with an incidence of only 1.3% in Japan, and a poor outcome. Read More

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http://dx.doi.org/10.1159/000506446DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7184850PMC

Short-Term Outcome and MRI Changes in Three Adult Patients with Sickle Cell Disease and Aseptic Osteonecrosis after Treatment with Hyperbaric Oxygen Therapy: A Preliminary Report.

Case Rep Oncol 2020 Jan-Apr;13(1):365-372. Epub 2020 Apr 2.

Hematology Section/Medical Oncology (NCCCR), Hamad General Hospital Doha, Doha, Qatar.

Background: Musculoskeletal manifestations are common in sickle cell disease (SCD). Vaso-occlusive crisis can manifest acutely as joint and bone pain, osteomyelitis and/or arthritis. It can also lead to chronic bone aches, bone deformities, degenerative arthritis, pathological fractures, and osteoporosis. Read More

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http://dx.doi.org/10.1159/000506330DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7184821PMC

Malignant Ovarian Steroid Cell Tumor, Not Otherwise Specified, Causes Virilization in a 4-Year-Old Girl: A Case Report and Literature Review.

Case Rep Oncol 2020 Jan-Apr;13(1):358-364. Epub 2020 Apr 2.

Department of Pediatrics, Ehime University Graduate School of Medicine, Toon, Japan.

We report a case of a 4-year-old girl with an ovarian steroid cell tumor, not otherwise specified (SCT-NOS). She was admitted to the hospital with progressing virilization and Cushing's syndrome, which included abnormality of the perineum, hirsutism, hypertrichosis, flushing of face, hoarseness, and weight gain. Blood testing showed a significantly increased testosterone level and slightly increased cortisol level. Read More

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http://dx.doi.org/10.1159/000506044DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7184839PMC

Acute Myeloid Leukemia after Low-Dose Radioiodine Therapy for Papillary Thyroid Carcinoma.

Case Rep Oncol 2020 Jan-Apr;13(1):207-211. Epub 2020 Mar 5.

Hamad Medical Corporation, Doha, Qatar.

Papillary thyroid carcinoma is the most common primary thyroid cancer. Most frequently treated with surgical resection, some cases require radioactive iodine (RAI) therapy. Studies have suggested that there is an increase in second primary malignancy after RAI therapy amongst thyroid cancer survivors including acute myeloid leukemia (AML) as an infrequent cancer related to RAI therapy; it has a higher relative risk ratio in patients on higher doses of radiation exposure. Read More

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http://dx.doi.org/10.1159/000505686DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7171228PMC

Is Gonadal Therapy a Promoter of Breast Cancer? Incidence of Breast Cancer in a Cohort of Survivors of Oncological Diseases Treated with Gonadal Steroids.

Case Rep Oncol 2020 Jan-Apr;13(1):347-357. Epub 2020 Mar 31.

Endocrinology Department, Portuguese Cancer Institute of Lisbon, Lisbon, Portugal.

There is a great controversy about hormonal replacement therapy in women among the members of the scientific community. Cancer survivors have sometimes had their ovary function totally or partially destroyed, thus affecting their development and quality of life. In this study, we were looking for adverse effects caused, eventually, by estroprogestative therapy in a cohort of supplemented survivors. Read More

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http://dx.doi.org/10.1159/000506395DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7154255PMC

Complete Remission of Relapsed Hodgkin's Lymphoma following Brentuximab Vedotin and Gemcitabine Combination Therapy with Severe Hypotension as Possible Treatment-Related Adverse Event: A Case Report.

Case Rep Oncol 2020 Jan-Apr;13(1):341-346. Epub 2020 Mar 26.

Dr. Sardjito General Hospital, Yogyakarta, Indonesia.

A 40-year-old Asian female with heavily treated relapsed Hodgkin's lymphoma showed complete remission (CR) after receiving 8 cycles of brentuximab vedotin (BV) in combination with gemcitabine as 4th line treatment. The patient remained in CR at the 18-month post-treatment follow-up. She developed severe hypotension (50/36 mm Hg) with upper and lower limb petechiae and edema after the addition of gemcitabine on the 6th cycle of BV. Read More

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http://dx.doi.org/10.1159/000505830DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7154270PMC

Outcome of Pregnancy in the Era of Pegylated Interferon Alpha 2a in Females with Essential Thrombocythemia: An Experience from Qatar.

Case Rep Oncol 2020 Jan-Apr;13(1):336-340. Epub 2020 Mar 26.

National Center for Cancer Care and Research, Department of Oncology - Hematology and BMT Section -, HMC, Doha, Qatar.

Myeloproliferative neoplasms are a diversified group of diseases of the hematopoietic stem cell, such as essential thrombocythemia (ET) and polycythemia vera. They are mainly caused by mutations in the following genes: and . All carry an increased risk to transform into acute leukemia or chronic myelogenous leukemia along with thrombosis and hemorrhagic complications. Read More

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http://dx.doi.org/10.1159/000506447DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7154247PMC

A Rare Case of Gastric Schwannoma: A Case Report and Literature Review.

Case Rep Oncol 2020 Jan-Apr;13(1):330-335. Epub 2020 Mar 25.

Department of Surgery, Yoshida General Hospital, Akitakata City, Japan.

In general, schwannoma is a benign and slow-glowing neoplasm that rarely occurs in the gastrointestinal tract as a submucosal tumor (SMT), with the most common site being the stomach. As gastric schwannoma (GS) is a rare tumor, there is limited data in the literature about its clinical features. The diagnosis of schwannoma can only be made by pathological examination with positive staining for S-100 protein. Read More

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http://dx.doi.org/10.1159/000506450DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7154269PMC

Cinacalcet for the Treatment of Humoral Hypercalcemia of Malignancy: An Introductory Case Report with a Pathophysiologic and Therapeutic Review.

Case Rep Oncol 2020 Jan-Apr;13(1):321-329. Epub 2020 Mar 25.

Department of Oncology, Marshfield Medical Center - Weston, Weston, Wisconsin, USA.

Hypercalcemia is an ominous development in the course of malignancy associated with a mean survival of only several months. A majority of cases of hypercalcemia are related to humoral hypercalcemia of malignancy (HHM), where hypercalcemia is caused by increased levels of circulating parathyroid hormone-related protein (PTHrP). Mainstay treatments in the management of HHM are intravenous fluids, intravenous bisphosphonates, and subcutaneous denosumab, although hypercalcemia oftentimes recurs despite these efforts. Read More

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http://dx.doi.org/10.1159/000506100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7154241PMC