732 results match your criteria Case reports in oncological medicine[Journal]


Peripheral Cytotoxic T Cell Lymphoma of the Appendix Presenting as Acute Appendicitis.

Case Rep Oncol Med 2020 16;2020:8569426. Epub 2020 Jun 16.

Department of Pathology, School of Veterinary Medicine, Shahrekord University, Shahrekord, Iran.

Introduction: Lymphoma of the appendix is a rare cause of acute appendicitis; however, acute appendicitis is a common first manifestation of appendiceal lymphomas. Cytotoxic peripheral T cell lymphoma (PTCL) is a type of aggressive non-Hodgkin lymphoma that portends a generally poor outcome. Cytotoxic PTCL of the appendix is extremely rare with few cases reported in the literature. Read More

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http://dx.doi.org/10.1155/2020/8569426DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7317332PMC

Intestinal Perforation due to Neutropenic Enterocolitis in a Patient Treated with Bevacizumab for Ovarian Cancer.

Case Rep Oncol Med 2020 16;2020:7231358. Epub 2020 Jun 16.

Department of Breast and Medical Oncology, National Cancer Center Hospital East, Kashiwa, Chiba, Japan.

Intestinal perforation is a rare adverse event of antineoplastic therapy. However, once it occurs, it is potentially fatal. This report describes a case of intestinal perforation caused by bevacizumab in a patient with ovarian cancer who concurrently developed neutropenic enterocolitis. Read More

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http://dx.doi.org/10.1155/2020/7231358DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7317333PMC

Localized Chronic Form of Langerhans Cell Histiocytosis in the Femur of a 16-Year-Old Male Successfully Treated with Radiofrequency Ablation.

Case Rep Oncol Med 2020 16;2020:4052034. Epub 2020 Jun 16.

3 Orthopaedic Dept., Aristotle University of Thessaloniki Medical School, Papageorgiou General Hospital, Thessaloniki Ring Road West, Nea Efkarpia, 56403 Thessaloniki, Greece.

Only three cases of patients suffering from a localized chronic form of Langerhans cell histiocytosis (LCH) successfully treated with radiofrequency ablation (RFA) have been published so far. This is the first case report of a patient with a localized chronic form of LCH of the femur, which was successfully treated with percutaneous image-guided RFA, and who was evaluated pre-RFA and followed up post-RFA for a period of 48 months, in order to validate the safety and efficacy of this method and to obtain imaging studies depicting the actual in situ changes taking place post-RFA. RFA was proved to be a safe and efficient method when treating patients with a localized chronic form of LCH. Read More

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http://dx.doi.org/10.1155/2020/4052034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7317322PMC

Lenvatininb as Treatment for Naïve Patients with Aggressive Thyroid Cancer Bone Metastases and Bad Performance Status.

Case Rep Oncol Med 2020 4;2020:8679149. Epub 2020 Jun 4.

Medical Oncology Department, Hospital Nuestra Señora de Valme, Seville, Spain.

Lenvatinib is an oral multityrosine kinase inhibitor (TKI) with proven effectiveness in the treatment of radioactive iodine- (RAI-) refractory and/or unresectable differentiated thyroid carcinoma (DTC). The present study reports the case of a 41-year-old male who underwent hemithyroidectomy in June 2015 due to a thyroid nodule with fine-needle aspiration follicular neoplasm cytology and no evidence of malignancy in the histopathological exam. Three years later, acute disabling clinical symptoms emerged, mainly high skeletal pain conditioned with an important performance status decrease. Read More

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http://dx.doi.org/10.1155/2020/8679149DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7292976PMC

Immunocheckpoint Inhibitor- (Nivolumab-) Associated Hypereosinophilia in Non-Small-Cell Lung Carcinoma.

Case Rep Oncol Med 2020 15;2020:7492634. Epub 2020 May 15.

Medicine/Division of Hematology/Oncology, Brooklyn VA Medical Center, 800 Poly Pl., Brooklyn, NY 11209, USA.

Immunocheckpoint inhibitor (ICI) therapy has provided significant clinical improvements in the treatment of several malignancies. The purpose of this report is to increase awareness of hypereosinophilia associated with checkpoint inhibitors, a topic that has been rarely reported. Hypereosinophilia may need to be addressed especially if eosinophil counts increase to levels where hypereosinophilic visceral complications can occur. Read More

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http://dx.doi.org/10.1155/2020/7492634DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7245658PMC

Rare Abdominal Wall Metastasis following Curative Resection of Gastric Cancer: What Can Be Learned from the Use of Percutaneous Catheters?

Case Rep Oncol Med 2020 9;2020:3738798. Epub 2020 May 9.

Department of Radiology, Moffitt Cancer Center, Tampa, Florida, USA.

In cancer care, tissue seeding after curative resections is a known potential complication, despite precautions taken during surgical treatment. We present an uncommon case of an abdominal wall metastasis along the tract of a surgical drain following gastrectomy for gastric adenocarcinoma. To our knowledge, this is the first case of such an occurrence in the setting of a negative staging peritoneal lavage. Read More

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http://dx.doi.org/10.1155/2020/3738798DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7244962PMC

Annexin A2 Expression in the Aerogenous Spread of Pulmonary Invasive Mucinous Adenocarcinoma with Gastric Lineage.

Case Rep Oncol Med 2020 18;2020:2492636. Epub 2020 May 18.

Department of Clinical Research, Shizuoka General Hospital, Japan.

Spread through air spaces (STAS) is a unique form of lung cancer progression associated with a worse prognosis. However, the mechanisms underlying STAS and the associated proteins remain unclear. Annexin A2 (ANX A2), which is a membrane-binding protein involved in cell adhesion, is known to promote cancer invasion. Read More

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http://dx.doi.org/10.1155/2020/2492636DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7254091PMC

An Episode of Pseudothrombocytopenia during Pembrolizumab Therapy in NSCLC Patient.

Case Rep Oncol Med 2020 8;2020:4196178. Epub 2020 May 8.

Department of Pneumonology, Oncology and Allergology, Medical University of Lublin, Poland.

Immunotherapy with immune checkpoint inhibitors (ICI) is a new option of treatment in a growing range of neoplasms. In addition to an antitumor effect, ICI are associated with autoimmune reactions resulting in a wide spectrum of toxicities that have not been seen in patients receiving chemotherapy. In this article, we present a case of a patient with advanced lung adenocarcinoma who developed an EDTA-dependent pseudothrombocytopenia (PTCP) during pembrolizumab therapy. Read More

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http://dx.doi.org/10.1155/2020/4196178DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7232686PMC

Splenectomy for Solitary Splenic Metastasis in Recurrent Papillary Thyroid Cancer. A Case Report and Literature Review.

Case Rep Oncol Med 2020 4;2020:2084847. Epub 2020 May 4.

Department of Surgical Oncology, American British Cowdray Medical Center, Mexico City, Mexico.

Thyroid cancer is the most common endocrine malignancy, presenting with 23 500 new cases per year in the United States. About 7-23% of the patients will present recurrent metastases disease during follow-up. The classic variant of papillary carcinoma is less aggressive compared to its other variants like diffuse sclerosing, tall cell or columnar cell, and insular variants, and the sites to which this metastasizes is already well identified. Read More

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http://dx.doi.org/10.1155/2020/2084847DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7232720PMC

Sistrunk Procedure on Malignant Thyroglossal Duct Cyst.

Case Rep Oncol Med 2020 16;2020:6985746. Epub 2020 Jan 16.

Department of Anatomical Pathology, Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia.

A thyroglossal duct cyst is a lesion that occurs as a result from failure of the thyroglossal duct to obliterate during fetal development. Malignant progression is a rare event that might occur in less than 1% of all cases. Because of its rarity, there are conflicting opinions regarding the management of the case. Read More

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http://dx.doi.org/10.1155/2020/6985746DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7201451PMC
January 2020

A Case Report of an Early Response to Definitive Chemoradiation for Esophageal Carcinoma Cuniculatum.

Case Rep Oncol Med 2020 25;2020:4674871. Epub 2020 Apr 25.

Department of Clinical Oncology, Hong Kong University Shenzhen Hospital, Shehzhen, China.

This case report describes a 63-year-old female with a locally advanced esophageal carcinoma cuniculatum treated with definitive chemoradiation who had a rapid and early response. This case is illustrative of an aggressive behavior with rapid response and rapid recurrence. The cases of esophageal carcinoma cuniculatum as well as the closely related clinical entity of verrucous carcinoma are reviewed suggesting good clinical outcomes after definitive therapy with chemoradiation and/or surgery. Read More

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http://dx.doi.org/10.1155/2020/4674871DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7196963PMC

A Case of Cardiac Tamponade in a Patient with Metastatic Renal Cell Carcinoma on Pazopanib Treatment.

Case Rep Oncol Med 2020 9;2020:9268923. Epub 2020 Apr 9.

Department of Medical Oncology, HealthCare Global Enterprises Ltd., Bangalore, India.

Asymptomatic minimal pericardial effusion may be frequently found in patients with hypothyroidism. Cardiac tamponade secondary to hypothyroidism is rarely referenced in medical literature. Hypothyroidism as an adverse effect of pazopanib (tyrosine kinase inhibitor) treatment leading to cardiac tamponade is an even rarer occurrence. Read More

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http://dx.doi.org/10.1155/2020/9268923DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7171608PMC

Ovarian Steroid Cell Tumor (Not Otherwise Specified): A Case Report of Ovarian Hyperandrogenism.

Case Rep Oncol Med 2020 8;2020:6970823. Epub 2020 Apr 8.

Endocrinology Department, Hedi Chaker Hospital, 3029 Sfax, Tunisia.

Steroid cell tumors (SCTs) (not otherwise specified (NOS)) are rare sex cord-stromal tumors of the ovary. These are associated with hormonal disturbances resulting in menstrual bleeding patterns and androgenic effects. We report the case of a 36-year-old female presented with hirsutism, signs of virilization, and elevated androgen levels. Read More

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http://dx.doi.org/10.1155/2020/6970823DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7168706PMC

Deep and Prolonged Response to Aurora A Kinase Inhibitor and Subsequently to Nivolumab in MYCL1-Driven Small-Cell Lung Cancer: Case Report and Literature Review.

Case Rep Oncol Med 2020 6;2020:8026849. Epub 2020 Apr 6.

Division of Hematology and Oncology, University of Minnesota, 420 Delaware St SE, MMC 480, Minneapolis, MN 55455, USA.

Small-cell lung carcinoma (SCLC) is one of the most aggressive solid tumors, and the prognosis has not improved significantly in 25 years. Despite a recent understanding of the genomic aberrations seen in SCLC, these insights have not led to any breakthroughs in treatment. We present a patient with SCLC harboring a novel MYCL1 fusion protein who experienced a prolonged disease course due to the use of Aurora A kinase inhibitor and subsequently nivolumab. Read More

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http://dx.doi.org/10.1155/2020/8026849DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7166265PMC

Long-Term Use of Ruxolitinib in an AML Patient with Posttransplant Steroid Refractory GVHD.

Case Rep Oncol Med 2020 6;2020:4936846. Epub 2020 Apr 6.

Medical Oncology, Augusta University, Augusta, GA, USA.

Ruxolitinib has become a new therapeutic option for steroid refractory graft-versus-host disease (srGVHD), with a substantial remission rate. Its anti-inflammatory properties by blocking interleukin pathways have made it a novel therapeutic approach to inflammatory disease processes, such as GVHD. The long-term use of ruxolitinib has not been explicitly studied outside the context in the treatment of multiple myeloma. Read More

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http://dx.doi.org/10.1155/2020/4936846DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7166298PMC

Complete Remission of Multiple Brain Metastases in a Patient with -Mutated Non-Small-Cell Lung Cancer Treated with First-Line Osimertinib without Radiotherapy.

Case Rep Oncol Med 2020 19;2020:9076168. Epub 2020 Mar 19.

Department of Respiratory Medicine, Okinawa Prefectural Yaeyama Hospital, Okinawa, Japan.

Osimertinib has demonstrated efficacy against stable or asymptomatic central nervous system (CNS) metastases of epidermal growth factor receptor () mutation-positive non-small-cell lung cancer (NSCLC) in phase 2 and 3 clinical trials that allowed prior CNS radiotherapy. However, the efficacy of osimertinib only or the optimal treatment combination or sequence of radiotherapy has not been investigated. A 74-year-old woman diagnosed with T4N1M1c Stage IVB lung adenocarcinoma with mutation presented with a left upper lobe mass and multiple bilateral lung metastases. Read More

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http://dx.doi.org/10.1155/2020/9076168DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7109584PMC

Metastasis of Ewing Sarcoma to the Pancreas: Case Report and Literature Review.

Case Rep Oncol Med 2020 21;2020:7075048. Epub 2020 Mar 21.

Penn State Hershey Medical Center, Hershey, Pennsylvania 17033, USA.

Ewing sarcoma (ES) is a highly aggressive malignant bone cancer. ES is part of the Ewing sarcoma family of tumors (ESFT), which express characteristic t(11;22) translocation as well as higher levels of CD99. Given that metastasis and tumor burden are significant prognostic factors in patient's response to treatment, prompt diagnosis is needed to effectively treat ESFT patients. Read More

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http://dx.doi.org/10.1155/2020/7075048DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7115132PMC

Metastatic Small-Cell Lung Cancer Presenting as Primary Adrenal Insufficiency.

Case Rep Oncol Med 2020 11;2020:7018619. Epub 2020 Mar 11.

Department of Internal Medicine, Grand Strand Medical Center, Myrtle Beach, SC, USA.

A 40-year-old male smoker with HIV was admitted for cough, hypotension, and abdominal pain for 5 days. Chest radiography showed a right lower lobe consolidation. CT of the chest, abdomen, and pelvis revealed paratracheal adenopathy, a 5. Read More

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http://dx.doi.org/10.1155/2020/7018619DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7106905PMC

Leptomeningeal Disease as a Rare Complication of Primary Penile Urethral Cancer.

Case Rep Oncol Med 2020 23;2020:6349456. Epub 2020 Mar 23.

Baylor College of Medicine, Houston, TX, USA.

Primary penile urethral cancer is a rare genitourinary malignancy arising from the epithelial lining of the urethra. Our patient is a 63-year-old male with newly diagnosed penile urethral carcinoma who presented with headache and was found to have leptomeningeal disease on imaging and cerebral spinal fluid analysis. He was treated with systemic and intrathecal chemotherapy with some response and improvement in symptoms. Read More

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http://dx.doi.org/10.1155/2020/6349456DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7128049PMC

Dual EGFR and ABL Tyrosine Kinase Inhibitor Treatment in a Patient with Concomitant EGFR-Mutated Lung Adenocarcinoma and BCR-ABL1-Positive CML.

Case Rep Oncol Med 2020 19;2020:4201727. Epub 2020 Mar 19.

Department of Respiratory Medicine, The University of Tokyo, Tokyo, Japan.

Tyrosine kinase inhibitor (TKI) combination is expected to increase in the era of precision medicine. TKI combination may be required to treat double primary cancers, each having a targetable gene, or to treat a single malignancy with multiple targetable genes. Here, we demonstrate the first report of dual EGFR and ABL TKI treatment in a patient with concomitant EGFR-mutated lung adenocarcinoma and BCR-ABL1-positive chronic myeloid leukemia (CML). Read More

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http://dx.doi.org/10.1155/2020/4201727DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7106872PMC

The Challenges of Managing Ovarian Cancer in the Developing World.

Case Rep Oncol Med 2020 11;2020:8379628. Epub 2020 Mar 11.

Department of Obstetrics and Gynecology, Université Catholique du Graben, Butembo, Congo.

Ovarian cancer has high morbidity and mortality rates among cancers of the reproductive system. The disease typically presents at late stage when the 5-year relative survival rate is only 29%. Similarly, access to prevention, early diagnosis, treatment, and palliative care for cancer-related disease is insufficient. Read More

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http://dx.doi.org/10.1155/2020/8379628DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7086431PMC

Response to Dabrafenib and Trametinib of a Patient with Metaplastic Breast Carcinoma Harboring a BRAF V600E Mutation.

Case Rep Oncol Med 2020 6;2020:2518383. Epub 2020 Mar 6.

Department of Breast and Medical Oncology, National Cancer Center Hospital, 5-1-1, Tsukiji, Chuo-ku, Tokyo 104-0045, Japan.

Background: Metaplastic breast carcinomas are rare and carry poor prognoses. They are also more aggressive than other breast cancers and are known for their resistance to chemotherapy. Prolonged treatment with dabrafenib and trametinib is a therapy for malignant melanoma that improves the progression-free survival and overall survival. Read More

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http://dx.doi.org/10.1155/2020/2518383DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7079252PMC

Advanced Lung Adenocarcinoma Patient with Amplification Identified by Comprehensive Genomic Profiling Benefits from Trastuzumab.

Case Rep Oncol Med 2020 1;2020:9072173. Epub 2020 Mar 1.

ACT Genomics, Co. Ltd., Taipei, Taiwan.

For non-small-cell lung cancer (NSCLC) patients without established actionable alterations in genes such as or , options for targeted therapy remain limited in clinical practice. About 5% of lung adenocarcinoma patients have tumors with genetic alterations, with even fewer patients harboring amplification. Currently, clinical trials mainly use IHC, FISH, or mutation testing to identify potential responders to ERBB2-targeting agents. Read More

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http://dx.doi.org/10.1155/2020/9072173DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7071810PMC

Unusual Presentation of Bilateral Radiation-Induced Angiosarcoma of the Breast.

Case Rep Oncol Med 2020 1;2020:5768438. Epub 2020 Mar 1.

Department of Surgery, Faculty of Medicine, University of Colombo, Sri Lanka.

Radiation-induced sarcoma of the breast is an iatrogenic malignancy that occurs secondary to radiotherapy, which is most commonly given following breast conservation surgery. It has an incidence of 3.2 per 1,000 patients at 15 years and is associated with a poor prognosis. Read More

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http://dx.doi.org/10.1155/2020/5768438DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7071809PMC

Malignant Phyllodes Tumor in an Adolescent Female: A Rare Case Report and Review of the Literature.

Case Rep Oncol Med 2020 28;2020:1989452. Epub 2020 Feb 28.

Cooper University Hospital, Department of Pathology, 1 Cooper Plaza, Camden, NJ 08103, USA.

Primary breast neoplasms are rare in adolescent females, most of which are benign. Phyllodes tumors constitute a remarkably small subset of breast neoplasms (0.3-0. Read More

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http://dx.doi.org/10.1155/2020/1989452DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7064852PMC
February 2020

Objective Clinical and Radiological Response under Sunitinib in a Case of Thigh Hidradenocarcinoma.

Case Rep Oncol Med 2020 25;2020:9656475. Epub 2020 Feb 25.

Medical Oncology Department, University Hospital Abderrahman Mami, Ariana, Boulevard de l'Hopital, 2080 Tunis, Tunisia.

A 56-year-old male was treated by local surgery in 1968 and 2005 for a left thigh lesion. A 2 local relapse occurred in 2015 and was treated by complete macroscopic surgery with histology concluding to a hidradenocarcinoma. A 3 locoregional relapse occurred in October 2018, with the presence of inflammatory ulcerated lesions. Read More

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http://dx.doi.org/10.1155/2020/9656475DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7060839PMC
February 2020

Hepatocellular Carcinoma: An Uncommon Metastasis in the Orbit.

Case Rep Oncol Med 2020 26;2020:7526042. Epub 2020 Feb 26.

University of Patras Medical School, Rion 26500, Greece.

Hepatocellular carcinoma (HCC) represents the most common type of primary cancer of the liver and is associated with poor prognosis. It is the most common cause of death in cirrhotic patients and in different studies was shown as the third most common cause of cancer-related deaths worldwide. Each year, approximately half a million people are diagnosed with HCC. Read More

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http://dx.doi.org/10.1155/2020/7526042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7061109PMC
February 2020

Synchronous Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma and Metastatic Squamous Cell Carcinoma of the Cervix Involving the Coronary Arteries Leading to Acute Myocardial Infarction.

Case Rep Oncol Med 2020 21;2020:6192754. Epub 2020 Feb 21.

SUNY Upstate Medical University Hospital, 750 E Adams St., Syracuse, NY 13210, USA.

A 66-year-old woman presented to the hospital with a one-month history of shortness of breath, fatigue, and postmenopausal vaginal bleeding and a one-week history of chest pain. This case report discusses the rare synchronous occurrence of two different malignancies in the setting of non-ST segment elevation myocardial infarction and the relation between these unfortunate events. Besides the case presented in this report, there have been only 13 reported cases of synchronous chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) associated with metastatic squamous cell carcinoma. Read More

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http://dx.doi.org/10.1155/2020/6192754DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7060405PMC
February 2020

Primary Pancreatic Lymphoma Masquerading as Carcinoma.

Case Rep Oncol Med 2020 26;2020:5160545. Epub 2020 Feb 26.

Department of Surgery, College of Medicine, Majmaah University, Ministry of Education, Al-Majmaah City, 11952, P. O. Box 66, Riyadh Region, Saudi Arabia.

Adenocarcinoma is the most common primary pancreatic neoplasm type, followed by secondary pancreatic lymphoma and primary pancreatic lymphoma (PPL). PPL is associated with peripancreatic lymphadenopathy and usually presents as a homogenous mass with extrapancreatic invasion into surrounding structures. However, localized involvement of the distal pancreas is uncommon, and diffuse involvement of the pancreas is even rarer. Read More

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http://dx.doi.org/10.1155/2020/5160545DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7061115PMC
February 2020

An Unusual Occurrence of Multiple Metachronous and Synchronous Primary Cancers in a Female Patient.

Case Rep Oncol Med 2020 18;2020:5691732. Epub 2020 Feb 18.

Mercy Hospital Fort Smith, Arkansas College of Osteopathic Medicine, USA.

Multiple primary cancers, although uncommon, have been increasing in incidence in recent years. This trend is likely due to advances in factors such as diagnostic imaging, life expectancy, and interventional modalities with associated adverse effects. The patient presented in this case report is a 59-year-old Caucasian female with an extensive medical history who developed multiple primary cancers of the breast, mouth, gastrointestinal system, and lung in the span of four years. Read More

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http://dx.doi.org/10.1155/2020/5691732DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7049841PMC
February 2020

Neoadjuvant Radiation with Concurrent 5-FU Resulting in Complete Pathologic Response in Stage IIIB Squamous Cell Carcinoma of the Urethra.

Case Rep Oncol Med 2020 14;2020:7948538. Epub 2020 Feb 14.

Division of Medical Oncology, MD Anderson Cancer Center, USA.

Squamous cell carcinoma (SCC) of the urethra is a rare malignancy, comprising less than 1% of all malignancies. The annual age-adjusted incidence of urethral SCC is 4.3 per million in men and 1. Read More

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http://dx.doi.org/10.1155/2020/7948538DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7042525PMC
February 2020

Ibrutinib-Induced Vasculitis in a Patient with Metastatic Colon Cancer Treated in Combination with Cetuximab.

Case Rep Oncol Med 2020 14;2020:6154213. Epub 2020 Feb 14.

Department of Hematology/Oncology, Northwell Cancer Institute, Lake Success, NY, USA.

Combination therapy with ibrutinib and cetuximab is being studied in a phase 1b/2 trial in patients with advanced gastrointestinal and genitourinary malignancies. Rash is a common cutaneous adverse effect for both medications. Ibrutinib is a Bruton's tyrosine kinase (BTK) inhibitor approved for the treatment of several hematologic malignancies. Read More

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http://dx.doi.org/10.1155/2020/6154213DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7042512PMC
February 2020

Bellini Duct Carcinoma Misdiagnosed with Urothelial Papillary Carcinoma.

Case Rep Oncol Med 2020 10;2020:3174674. Epub 2020 Feb 10.

Faculty of Medicine and Medical Sciences, Holy Spirit University of Kaslik (USEK), Jounieh, Lebanon.

Background: Collecting (Bellini) duct carcinoma (CDC) or Bellini duct carcinoma (BDC) is a rare subtype of kidney tumors, accounting for less than 3% and known to have the worst prognosis. It is known to have multiple clinical presentations; this is why it can be easily misdiagnosed. The aim of this article is to present a case of CDC that was initially misdiagnosed with urothelial papillary carcinoma (UPC) in a 41-year-old male. Read More

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http://dx.doi.org/10.1155/2020/3174674DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7035507PMC
February 2020

Male Breast Cancer: Reevaluate Our Opinion.

Case Rep Oncol Med 2020 6;2020:6245415. Epub 2020 Feb 6.

Department of Internal Medicine, Nassau University Medical Center, East Meadow, Nassau County, NY, USA.

Male breast cancers (MBCs) are relatively uncommon malignancy with less than 1% incidence. MBC presents at a later age with a more advanced presentation as compared to the female breast cancer. Due to the paucity of the number of cases and trials regarding the MBC, female breast cancer treatment protocols are applied. Read More

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http://dx.doi.org/10.1155/2020/6245415DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7026701PMC
February 2020

Ductal Adenocarcinoma Ex Pleomorphic Adenoma of the Lacrimal Gland: a Rare and Morbid Malignancy.

Case Rep Oncol Med 2020 3;2020:1790106. Epub 2020 Feb 3.

Department of Hematology-Oncology, SUNY Upstate Medical University, Syracuse, NY 13210, USA.

Carcinoma ex pleomorphic adenoma (Ca ex PA) is a rare malignant transformation of a benign primary pleomorphic adenoma (PA). We report the case of a 62-year-old male who presented with a swelling over his left temple. Imaging revealed a lytic lesion over the left orbital wall with soft tissue extension suggestive of malignancy. Read More

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http://dx.doi.org/10.1155/2020/1790106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7021468PMC
February 2020

A 5-Fluorouracil-Induced Hyperammonemic Encephalopathy Challenged with Capecitabine.

Case Rep Oncol Med 2020 31;2020:4216752. Epub 2020 Jan 31.

University of Florida College of Medicine-Jacksonville, Department of Medicine, Division of Hematology and Oncology, USA.

Cancer patients presenting with altered mental status demand a broad differential with early recognition of the etiology. Failure to do so is associated with increased morbidity and mortality. Causes that must be considered include organ involvement of the cancer, electrolytes abnormalities, and even chemotherapeutic agents. Read More

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http://dx.doi.org/10.1155/2020/4216752DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7013286PMC
January 2020

A Nonpediatric Extraosseous Ewing Sarcoma of the Pancreas: Differential Diagnosis and Therapeutic Strategies.

Case Rep Oncol Med 2020 30;2020:2792750. Epub 2020 Jan 30.

Department of Internal Medicine, Texas Health Presbyterian Hospital Dallas, Texas 75231, USA.

Extraosseous Ewing's sarcoma is a rare and aggressive malignant tumor with a poor prognosis. The pancreas is an extremely uncommon primary site, with only 27 cases that have been published worldwide. We report a 26-year-old female who presented with 5 days of left upper quadrant pain, nausea, and vomiting. Read More

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http://dx.doi.org/10.1155/2020/2792750DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7013316PMC
January 2020

Stage IV Small Lymphocytic Lymphoma Presenting with Unilateral Vision Loss.

Case Rep Oncol Med 2020 11;2020:3752409. Epub 2020 Jan 11.

Department of Graduate Medical Education, CarePoint Health Bayonne Medical Center, 29 E. 29 Street, Bayonne, NJ 07002, USA.

Small lymphocytic lymphoma (SLL) is a manifestation of chronic lymphocytic leukemia (CLL) in which malignant B-cell lymphocytes accumulate in the lymph nodes or bone marrow. In this report, we describe the medical course of a patient diagnosed with stage IV small cell lymphocytic lymphoma, who presented to the emergency room with acute neurologic manifestations of SLL. Read More

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http://dx.doi.org/10.1155/2020/3752409DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7001663PMC
January 2020

Undifferentiated Nasopharyngeal Carcinoma Presenting with Shoulder Mass.

Case Rep Oncol Med 2020 24;2020:2586248. Epub 2020 Jan 24.

Department of Radiology, Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia.

Nasopharyngeal cancer (NPC) is the most common cancer among head and neck cancer that usually presented with unilateral neck mass. Unusual symptoms of NPC can lead us to diagnosis misleading and delayed definitive treatment. We present a case of NPC with bone metastasis in the shoulder. Read More

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http://dx.doi.org/10.1155/2020/2586248DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7003262PMC
January 2020

A Huge Pelvic-Abdominal Malignant GIST Tumour in a Patient with Neurofibromatosis Type 1: Case Report and Literature Review.

Case Rep Oncol Med 2020 4;2020:6590307. Epub 2020 Jan 4.

Oncology Center, King Hamad University Hospital, Bahrain.

Gastrointestinal stromal tumours are rare tumours of the gastrointestinal tract (GIT) accounting for 0.1%-3% of all gastrointestinal tumours. The most common location is the stomach (55%) followed by the small bowel (31. Read More

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http://dx.doi.org/10.1155/2020/6590307DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6964723PMC
January 2020

A Rare Case of Intracranial Nongerminomatous Germ Cell Tumor in a 21-Year-Old Romanian Male.

Case Rep Oncol Med 2020 3;2020:3787250. Epub 2020 Jan 3.

Department of Neurological Critical Care Medicine, AtlantiCare Regional Medical Center, 1925 Pacific Avenue, Atlantic City, NJ, USA.

Extragonadal germ cell tumors are a rare entity that is more prevalent in infants and young children, with preference to midline structures. The category of intracranial germ cell tumors is divided into pure germ cell tumors (GCTs) versus nongerminomatous germ cell tumors (NGGCTs). They are usually present in the second decade of life with a male preponderance. Read More

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http://dx.doi.org/10.1155/2020/3787250DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6964716PMC
January 2020

Disseminated Intravascular Coagulation and Malignancy: A Case Report and Literature Review.

Case Rep Oncol Med 2020 2;2020:9147105. Epub 2020 Jan 2.

Department of Internal Medicine, AMITA Health Saint Francis Hospital, 355 Ridge Avenue, Evanston, IL 60202, USA.

Disseminated Intravascular Coagulation (DIC) is a disorder of coagulation which is commonly seen as a complication of infections, traumas, obstetric diseases, and cancers especially hematological and rarely solid cancers. DIC may rarely be the presenting feature of an undiagnosed malignancy. It may present in the form of different phenotypes which makes its diagnosis difficult and leads to high mortality. Read More

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http://dx.doi.org/10.1155/2020/9147105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6959140PMC
January 2020

Acute Myeloid Leukemia Presenting as Myeloid Sarcoma with a Predisposition to the Gynecologic Tract.

Case Rep Oncol Med 2019 30;2019:4189275. Epub 2019 Dec 30.

Division of Hematology and Oncology, Weill Cornell Medical College, New York, NY, USA.

Myeloid sarcoma (MS) is a rare, extramedullary tumor consisting of immature white blood cells of myeloid lineage. MS is usually associated with the concurrent diagnosis of acute myeloid leukemia (AML) but can also present in the absence of bone marrow disease or at relapse of AML. MS of the gynecologic tract is exceedingly rare; however, it is hypothesized that it is likely more prevalent than previously understood given postmortem findings and persistence in preserved ovarian tissue. Read More

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http://dx.doi.org/10.1155/2019/4189275DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6955122PMC
December 2019

Combined Cerebellar and Spinal Cord Deficits Caused by an Underlying Gynecologic Malignancy.

Case Rep Oncol Med 2020 8;2020:9021843. Epub 2020 Jan 8.

Department of Hematology and Oncology, Kaiser Permanente Los Angeles Medical Center, Los Angeles, CA, USA.

Paraneoplastic cerebellar degeneration (PCD) is an uncommon autoimmune disorder targeting antigens within the nervous system and is usually associated with an underlying malignancy. Neurologic symptoms frequently precede the cancer diagnosis, which is most often seen in women with breast or gynecologic tumors. Anti-Yo-related PCD is the most common PCD syndrome, and one of the best understood. Read More

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http://dx.doi.org/10.1155/2020/9021843DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6973182PMC
January 2020

Ipilimumab- and Nivolumab-Induced Colitis Causing Severe Hypokalemia and QTc Prolongation.

Case Rep Oncol Med 2019 26;2019:7896749. Epub 2019 Dec 26.

Department of Internal Medicine, University of Illinois College of Medicine Peoria, Peoria, IL, USA.

Immune-mediated colitis is an uncommon but well-documented adverse event in patients receiving nivolumab or ipilimumab therapy. In this report, we present a 69-year-old man who developed severe hypokalemia and colitis with significant corrected Q-T segment (QTc) prolongation as a result of combination nivolumab-ipilimumab immunotherapy for clear cell renal cell carcinoma. Read More

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http://dx.doi.org/10.1155/2019/7896749DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6948332PMC
December 2019

Nivolumab-Induced, Late-Onset, Steroid-Sensitive, High-Grade Pneumonitis and Durable Tumor Suppression in Metastatic Renal Cell Carcinoma: A Case Report.

Case Rep Oncol Med 2019 26;2019:6759472. Epub 2019 Dec 26.

Hematology/Oncology, University of Texas Medical Branch, Galveston, TX, USA.

Nivolumab, an antiprogrammed death-1 checkpoint inhibitor, has been approved for use in unresectable/metastatic renal cell carcinoma (RCC). Nivolumab-induced pneumonitis, a rare, but often severe and potentially life-threatening immune-related adverse event, has been reported, typically, early during the treatment. Due to its low incidence, more studies are needed to better elucidate this condition and its possible effects on cancer progression. Read More

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http://dx.doi.org/10.1155/2019/6759472DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6944973PMC
December 2019

A Case of Long-Term Survival after Checkpoint Inhibitor Pneumonitis in a Patient with Squamous Cell Lung Cancer.

Case Rep Oncol Med 2019 26;2019:4836404. Epub 2019 Dec 26.

Division of Respiratory Medicine, Chiba Cancer Center, Chiba, Japan.

The management of grade 1 checkpoint inhibitor pneumonitis (CIP) is to withhold immune checkpoint inhibitors; however, the natural history of this condition is unknown. We herein report the case of a woman with squamous cell lung cancer who was a long-term survivor after CIP. After 4 rounds of treatment with nivolumab, a chest CT revealed a reticular pattern and ground-glass attenuation with shrinkage of the primary nodule. Read More

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http://dx.doi.org/10.1155/2019/4836404DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6948310PMC
December 2019

Histological Characteristics of Myxoid (Metaplastic) Meningioma in a 44-Year-Old Woman.

Case Rep Oncol Med 2019 6;2019:9207632. Epub 2019 Dec 6.

Department of Neurosurgery, National Hospital Organization, Osaka Minami Medical Center, Osaka, Japan.

Myxoid (metaplastic) meningioma is the rarest WHO grade 1 meningioma, and its histological characteristics are useful in diagnostics. We present the case report of a myxoid (metaplastic) meningioma in a 44-year-old woman to highlight the important histological features and observations that are critical for making an accurate diagnosis. We report a rare myxoid meningioma using magnetic resonance imaging (MRI) images and its histopathological features. Read More

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http://dx.doi.org/10.1155/2019/9207632DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6925932PMC
December 2019

Unique Case Report of a Meningeal Sarcoma Arising during Ongoing Treatment for Progressing Intraparenchymal Glioma.

Case Rep Oncol Med 2019 27;2019:7950782. Epub 2019 Nov 27.

HealthPartners Neuroscience Center, St Paul, MN, USA.

Radiation-induced sarcomas in the brain are extremely rare, usually occur with an average latency of 9 years, and are associated with poor outcomes. Latency periods shorter than 1 year may indicate a genetic predisposition such as Li-Fraumeni syndrome. A 34-year-old man underwent initial tumor resection and radiation therapy for a World Health Organization (WHO) Grade II Astrocytoma. Read More

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http://dx.doi.org/10.1155/2019/7950782DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6900946PMC
November 2019

Safe Transition to Pembrolizumab following Ipilimumab-Induced Guillain-Barré Syndrome: A Case Report and Review of the Literature.

Case Rep Oncol Med 2019 22;2019:5490707. Epub 2019 Nov 22.

Division of Hematology-Oncology, Department of Medicine, University of Arizona Cancer Center, 1515 N. Campbell Ave., Tucson, AZ 85724-5024, USA.

Background: Immune checkpoint inhibitors are novel therapies with indications for treating several solid cancers. They are associated with immune-related adverse events, which are generally well tolerated. Though rare, severe side effects may be life-threatening. Read More

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http://dx.doi.org/10.1155/2019/5490707DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6893263PMC
November 2019