611 results match your criteria Case reports in neurological medicine[Journal]


The Successful Use of Infliximab in a Relapsing Case of Susac's Syndrome.

Case Rep Neurol Med 2020 10;2020:9317232. Epub 2020 Jun 10.

Sydney Medical School, University of Sydney, Sydney, Australia.

Susac's syndrome is a rare and debilitating disease characterized by the triad of encephalopathy, branch retinal artery occlusions, and sensorineural hearing loss. All manifestations may not be clinically apparent at presentation resulting in delayed diagnosis. Early recognition of the syndrome may prevent disease sequelae such as permanent cognitive, visual, and hearing loss. Read More

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http://dx.doi.org/10.1155/2020/9317232DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7303758PMC

Anti-NMDAR-Positive Small-Cell Lung Cancer Paraneoplastic Limbic Encephalitis: A Case Report and Literature Review.

Case Rep Neurol Med 2020 2;2020:5269352. Epub 2020 Jun 2.

Department of Neurology, SUNY Upstate Medical University Hospital, 750 E Adams St., Syracuse, NY 13210, USA.

Introduction: Paraneoplastic limbic encephalitis (PLE) is a rare disease that presents as rapid onset dementia characterized by short-term memory loss (STM), anxiety, and behavioral changes. Anti-NMDAR antibodies are unfrequently reported in PLE associated with small-cell lung cancer (SCLC). Given that PLE can precede the diagnosis of cancer, it is very important that once infectious, metabolic, nutritional, or structural disorders associated with short-term memory loss are ruled out that vigorous effort must be made to rule out underlying malignancy. Read More

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http://dx.doi.org/10.1155/2020/5269352DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7288224PMC

Intravascular Lymphoma with Progressive CNS Hemorrhage and Multiple Dissections.

Case Rep Neurol Med 2020 10;2020:6134830. Epub 2020 Jan 10.

Department of Neurology, University of Utah, 175 N Medical Dr., Salt Lake City, UT 84132, USA.

Introduction: Intravascular lymphoma (IVL) is an uncommon and often fatal disease characterized by intraluminal proliferation of lymphomatous cells within blood vessels. Because of a heterogeneous clinical presentation and lack of sensitive diagnostic protocols, diagnosis of IVL is most often made at autopsy. However, with early diagnosis and appropriate chemotherapy, the prognosis is greatly improved and complete remission is possible. Read More

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http://dx.doi.org/10.1155/2020/6134830DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7201472PMC
January 2020

Acute Brainstem Dysfunction Caused by Cavernous Sinus Dural Arteriovenous Fistula.

Case Rep Neurol Med 2020 23;2020:2630959. Epub 2020 May 23.

Department of Neurology, Kitano Hospital, Tazuke Kofukai Medical Research Institute, Osaka, Japan.

Symptoms of cavernous sinus dural arteriovenous fistula depend on the drainage patterns and are very diverse. Among these, brainstem dysfunction is a rare but serious complication. Here, we describe a case with isolated and rapidly progressive brainstem dysfunction due to cavernous sinus dural arteriovenous fistula. Read More

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http://dx.doi.org/10.1155/2020/2630959DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7271059PMC

Conversion Disorder: Early Diagnosis and Personalized Therapy Plan Is the Key.

Case Rep Neurol Med 2020 10;2020:1967581. Epub 2020 Jan 10.

Department of Neurology, University of Arkansas for Medical Sciences, Little Rock, AR, USA.

Conversion disorder is characterized by one or more symptoms of altered voluntary motor or sensory functions that cannot be explained by a neurological disease (Keynejad, 2019; Samuels et al., 2019). We present a patient with conversion disorder and discuss her process in overcoming this disorder. Read More

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http://dx.doi.org/10.1155/2020/1967581DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7201851PMC
January 2020

Manganese Neurotoxicity as a Complication of Chronic Total Parenteral Nutrition.

Case Rep Neurol Med 2020 23;2020:9484028. Epub 2020 Apr 23.

Department of Medicine, SUNY Upstate Medical University, Syracuse, NY, USA.

Manganese accumulation in the central nervous system creates clinical symptoms of cognitive dysfunction, behavioral changes, and movement disorders resembling Parkinson's disease. Radiographic features of this rare clinical entity include symmetric T1 hyperintensities in the bilateral globus pallidi, with corresponding hypointensities on T2-weighted images. Total parenteral nutrition (TPN) is an increasingly used potentially lifesaving therapy for patients who cannot tolerate enteral nutrition. Read More

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http://dx.doi.org/10.1155/2020/9484028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7196137PMC

Medically Refractory Multiple Sclerosis Is Successfully Treated with Plasmapheresis in a Super Morbidly Obese Pregnant Patient.

Case Rep Neurol Med 2020 4;2020:4536145. Epub 2020 Apr 4.

Eastern Maine Medical Center, Department of Neurology, Bangor, USA.

Multiple sclerosis (MS) is a relapse remitting immune-mediated demyelinating neurological disorder that primarily affects women of childbearing age. In most patients, the hormonal changes during pregnancy are protective against MS relapses. When relapses do occur, treatment options are limited to use of intravenous steroids and plasmapheresis rescue therapy. Read More

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http://dx.doi.org/10.1155/2020/4536145DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7160736PMC

Contrast-Induced Encephalopathy following Cerebral Angiography in a Hemodialysis Patient.

Case Rep Neurol Med 2020 4;2020:3985231. Epub 2020 Apr 4.

University Hospital Mostar, Department of Neurology, Mostar, Bosnia and Herzegovina.

Contrast-induced encephalopathy (CIE) is a rare complication of contrast media use during angiographic procedures. With the growing use of endovascular interventions, this complication is likely to become more common. We present a case of a 46-year-old woman with hypertension, hypothyroidism, and chronic renal failure. Read More

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http://dx.doi.org/10.1155/2020/3985231DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7160713PMC

Composite Anatomical Variations between the Sciatic Nerve and the Piriformis Muscle: A Nepalese Cadaveric Study.

Case Rep Neurol Med 2020 31;2020:7165818. Epub 2020 Mar 31.

Department of Anatomy, Gandaki Medical College, Pokhara, Nepal.

Piriformis syndrome is a rare syndrome which is one of the main causes of nondiscogenic sciatica causing severe low back pain due to entrapment of sciatic nerve either by the hypertrophy or by inflammation of the piriformis muscle. We have carried out dissection in 20 Nepalese cadavers. Out of 40 dissected gluteal regions, 37 exhibited typical appearance of sciatic nerve, piriformis muscle, and their relations resembling type-a, whereas 3 gluteal regions showed composite structural variations resembling type-b and type-c based on Beaton and Anson's classification. Read More

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http://dx.doi.org/10.1155/2020/7165818DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7150691PMC

Clinical Features of Painful Ophthalmoplegia with a High-Intensity Ring Appearance around the Optic Nerve on MRI: A Case Series.

Case Rep Neurol Med 2020 30;2020:6737018. Epub 2020 Mar 30.

Department of Neurology, Toyohashi Municipal Hospital, Toyohashi, Japan.

Objective: Painful ophthalmoplegia includes nonspecific magnetic resonance imaging (MRI) manifestations and various clinical features including orbital pain and cranial nerve palsies. Treatment for painful ophthalmoplegia remains controversial. The aim of this report was to describe detailed clinical features, MRI findings, treatments, and prognosis of patients with painful ophthalmoplegia. Read More

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http://dx.doi.org/10.1155/2020/6737018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7149416PMC

Effect of Zolpidem in the Aftermath of Traumatic Brain Injury: An MEG Study.

Case Rep Neurol Med 2020 20;2020:8597062. Epub 2020 Mar 20.

Institute of Neuroscience and Medicine (INM-4), Medical Imaging Physics, Forschungszentrum Jülich GmbH, 52425 Jülich, Germany.

In the past two decades, many studies have shown the paradoxical efficacy of zolpidem, a hypnotic used to induce sleep, in transiently alleviating various disorders of consciousness such as traumatic brain injury (TBI), dystonia, and Parkinson's disease. The mechanism of action of this effect of zolpidem is of great research interest. In this case study, we use magnetoencephalography (MEG) to investigate a fully conscious, ex-coma patient who suffered from neurological difficulties for a few years due to traumatic brain injury. Read More

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http://dx.doi.org/10.1155/2020/8597062DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7109561PMC

Into a Shaking Limbo: Case Report of a Nonneoplastic Limbic Encephalitis with Faciobrachial Dystonic Seizures and Parkinsonism.

Authors:
Vijay Renga

Case Rep Neurol Med 2020 15;2020:3796807. Epub 2020 Mar 15.

Department of Neurology, Dartmouth Hitchcock Medical Center, Geisel School of Medicine at Dartmouth, One Medical Center Drive, Lebanon, NH 03756, USA.

This case report describes a rare but classic presentation of a non-paraneoplastic, antibody-mediated limbic encephalitis. The clinical course did put us in a limbo as it evolved from seizure to Parkinsonism and then from metastasis to stroke, before it finally announced itself by its pathognomonic finding. Knowledge of this rare condition is important as early identification and treatment can change the course. Read More

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http://dx.doi.org/10.1155/2020/3796807DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7099203PMC

Bilateral Femoral Neuropathy: A Rare Complication of Drug Overdose due to Prolonged Posturing in Lithotomy Position.

Case Rep Neurol Med 2020 10;2020:2352850. Epub 2020 Mar 10.

Neurology Department, Sunderland Royal Hospital, South Tyneside & Sunderland NHS Foundation Trust, Sunderland, UK.

Background: Bilateral femoral neuropathy is an uncommon complication of various surgical and nonsurgical procedures, such as pelvic/abdominal surgery or vaginal delivery. . We report a case of a 41-year-old male who was found unresponsive against the wall in a "lithotomy-type" position with both knees flexed at approximately 90 degrees and both hips flexed and externally rotated at approximately 90 and 60 degrees, respectively, 24-48 hours after a drug overdose (combination of dihydrocodeine, paracetamol, diazepam, and amitriptyline). Read More

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http://dx.doi.org/10.1155/2020/2352850DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7086416PMC

A Transforaminal Endoscopic Surgical Technique for Treating Lumbar Disc Herniation in the Setting of Spina Bifida.

Case Rep Neurol Med 2020 9;2020:1076847. Epub 2020 Mar 9.

Department of Neurosurgery, Warren Alpert Medical School of Brown University, Providence, RI, USA.

Recent literature suggests that adult patients with spina bifida receive surgery for degenerative disc disease at higher rates than the general population. However, sometimes the complex anatomic features of co-occurring spina bifida and lumbar disc herniation can significantly challenge standard surgical techniques. Here, the technical steps are presented for treating a foraminal lumbar 4-5-disc herniation in the setting of a patient with multifaceted degenerative and spina bifida occulta anatomy. Read More

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http://dx.doi.org/10.1155/2020/1076847DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7085356PMC

Unusual Phenotype and Disease Trajectory in Kearns-Sayre Syndrome.

Case Rep Neurol Med 2020 27;2020:7368527. Epub 2020 Feb 27.

Krankenhaus Stockerau, Stockerau, Austria.

Objective: To describe unusual course and unusual phenotypic features in an adult patient with Kearns-Sayre syndrome (KSS). . The patient is a 49-year-old male with KSS, diagnosed clinically upon the core features, namely, onset before the age 20 of years, pigmentary retinopathy, and ophthalmoparesis, and the complementary features, namely, elevated CSF protein, cardiac conduction defects, and cerebellar ataxia. Read More

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http://dx.doi.org/10.1155/2020/7368527DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7064856PMC
February 2020

Early Aggressive Immunotherapy Improves Functional Outcome in Chronic Immune Sensory Polyradiculopathy.

Case Rep Neurol Med 2020 20;2020:6595086. Epub 2020 Feb 20.

Department of Neurology, National Neuroscience Institute, 11 Jalan Tan Tock Seng, Singapore 308433.

Chronic immune sensory polyradiculopathy (CISP) is an uncommon and treatable inflammatory disorder of the proximal sensory nerve roots. Patients typically present with severe sensory ataxia, normal motor examination, unsteady gait, and normal nerve conduction studies (NCS). We describe an elderly man who presented with a two-week history of progressive numbness of both legs and recurrent falls. Read More

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http://dx.doi.org/10.1155/2020/6595086DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7054787PMC
February 2020

Immediate Response to Chemotherapy in an Adult Neuroblastoma Patient Presenting with Cord Compression.

Case Rep Neurol Med 2020 19;2020:6401497. Epub 2020 Feb 19.

Department of Pediatric Hematology Oncology and Stem Cell Transplantation, King Fahad Specialist Hospital, Dammam, Saudi Arabia.

We report a case of a 31-year-old female patient with high-risk neuroblastoma (NBL) who presented with a history of static back pain and bilateral lower limb weakness for almost a month. Her primary tumor was located in the right paraspinal region, causing spinal cord compression (SCC). Chemotherapy was administered with an immediate clinical improvement noted after 24 hours of starting treatment. Read More

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http://dx.doi.org/10.1155/2020/6401497DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7049824PMC
February 2020

A Patient with Combined CADASIL and MTHFR Homozygosity.

Case Rep Neurol Med 2020 17;2020:4980847. Epub 2020 Feb 17.

American University of Beirut Medical Center, Department of Neurology, Beirut, Lebanon.

Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) is an inherited disorder caused by a mutation in the NOTCH 3 gene, characterized by early onset of subcortical lacunar infarcts in the absence of vascular risk factors and cerebral microbleeds. Homozygosity for the factor Methylenetetrahydrofolate Reductase (MTHFR) is also associated with lacunar stroke risk and cerebral small-vessel disease regardless of the homocysteine level. The coexistence of MTHFR C677T homozygosity and NOTCH 3 mutation has never been reported in the literature previously, and that brings up the challenge of antithrombotic treatment in the presence of cerebral microbleeds. Read More

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http://dx.doi.org/10.1155/2020/4980847DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7048904PMC
February 2020

Efficacy of Tocilizumab in Limbic Encephalitis with Anti-CASPR2 Antibodies.

Case Rep Neurol Med 2020 14;2020:5697670. Epub 2020 Feb 14.

Neurology Unit, S. Giovanni di Dio Hospital, Florence, Italy.

We report the case of a 64-year-old man who presented with subacute memory, balance impairment, behavioral and mood changes, and epileptic seizures. Magnetic resonance imaging (MRI) showed bilateral hippocampal abnormalities. Brain [F]-FDG fluorodeoxyglucose positron emission tomography (PET) revealed hypometabolism in both the temporal lobe as well as in the left insular and parietal regions. Read More

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http://dx.doi.org/10.1155/2020/5697670DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7042499PMC
February 2020

Treatment of a Woman with Inoperable Meningioma Using Mifepristone for 26 Years.

Case Rep Neurol Med 2020 11;2020:5162918. Epub 2020 Feb 11.

The University Hospital of Brasília and Clinic of Endocrinology and Neurology (CLINEN), Brasília, DF, Brazil.

Meningioma treatment includes observation of its growth or surgery with or without associated radiotherapy. However, drug treatment can be used for tumors deemed inoperable because of their size and location. Due to the presence of progesterone receptors, the use of antiprogestin mifepristone is recommended. Read More

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http://dx.doi.org/10.1155/2020/5162918DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7036131PMC
February 2020

Endoscopic Endonasal Resection of Meckel's Cave Epidermoid Cysts: Case Discussion and Literature Review.

Case Rep Neurol Med 2020 7;2020:7853279. Epub 2020 Feb 7.

Department of Neurological Surgery, Stritch School of Medicine, Loyola University Medical Center, Maywood, IL, USA.

Meckel's cave (MC) epidermoid cysts are relatively uncommon lesions. In cases where surgical excision is indicated, resection is often carried out via a frontosphenotemporal craniotomy from an anterolateral approach or a temporal craniotomy with or without a petrosectomy for a lateral corridor; both of these routes are associated with brain retraction and potential neurovascular injury. The anterior location of MC in the middle cranial fossa makes safe access via posterior fossa-based approaches-such as the retrosigmoid approach-challenging as well. Read More

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http://dx.doi.org/10.1155/2020/7853279DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7029282PMC
February 2020

Subcutaneous EEG Monitoring Reveals AED Response and Breakthrough Seizures.

Case Rep Neurol Med 2020 28;2020:8756917. Epub 2020 Jan 28.

Zealand University Hospital, Department of Neurology, Roskilde, Denmark.

Unrecognized seizures are a common problem in temporal lobe epilepsy potentially leading to undertreatment. Objective seizure counting using EEG home monitoring for prolonged periods with a minimally invasive device has not been feasible until now. We present a case in which a novel, subcutaneous EEG device was utilized to provide an objective seizure count. Read More

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http://dx.doi.org/10.1155/2020/8756917DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7008291PMC
January 2020

Ominous Occurrence of Spinal Intradural Primary Malignant Peripheral Nerve Sheath Tumor Four Decades following Radiation Therapy for Testicular Seminoma.

Case Rep Neurol Med 2020 27;2020:1792582. Epub 2020 Jan 27.

Department of Neurological Surgery, University Hospitals Cleveland Medical Center, Cleveland, OH, USA.

Primary intradural malignant peripheral nerve sheath tumor (MPNST) is an extremely rare diagnosis and is associated with an extremely poor prognosis. A 77-year-old man diagnosed with an intradural MPNST, more than 40 years after radiation for a testicular seminoma, is reported. Intradural MPNSTs of the spine outside the setting of neurofibromatosis is extremely rare and can masquerade as common benign nerve sheath tumors, on imaging. Read More

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http://dx.doi.org/10.1155/2020/1792582DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7007932PMC
January 2020

Anti-NMDAR Encephalitis: Higher Suspicious Needed for Earlier Diagnosis (Case Report, Literature Review and Diagnostic Criteria).

Case Rep Neurol Med 2019 28;2019:7476254. Epub 2019 Dec 28.

Emergency Physician, St. Vincent's Hospital, University of Melbourne, Melbourne, Australia.

Background: Auto-immune mediated anti-NMDA receptor encephalitis is a very common delayed diagnosed encephalitis which predominately affecting young population.

Objectives: This encephalitis is relatively unknown amongst emergency physicians and a majority of patients are admitted to psychiatric wards before their diagnosis is confirmed and appropriate treatments are commenced. We reported a case of a 22-year-old female presented to our emergency department with acute psychiatric symptoms. Read More

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http://dx.doi.org/10.1155/2019/7476254DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6949662PMC
December 2019

MELAS Missed for Years: Stroke-Like Lesions Are No Indication for Brain Biopsy.

Authors:
J Finsterer

Case Rep Neurol Med 2019 27;2019:9312451. Epub 2019 Dec 27.

Krankenanstalt Rudolfstiftung, Messerli Institute, Vienna, Austria.

A 56-year-old female with a history of chronic alcoholism until age 38 y with a relapse between ages 45 and 46 y developed seizures, psychosis, and hemianopia to the left at age 46 y. Imaging revealed a right parieto-occipital lesion with intralesional bleeding. Five months after the first lesion she developed a second left parieto-occipital lesion, resulting in cortical blindness. Read More

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http://dx.doi.org/10.1155/2019/9312451DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6948273PMC
December 2019

A Case Report of Extensive Cerebral Venous Sinus Thrombosis as a Presenting Sign of Relapsing Nephrotic Syndrome.

Case Rep Neurol Med 2019 27;2019:6840240. Epub 2019 Dec 27.

University of South Florida, Department of Neurology, Tampa, FL, USA.

Nephrotic syndrome is defined by three characteristic features including proteinuria of >3 g in 24 hours, hypoalbuminemia of less than 3 g/dL, and peripheral edema. Multiple nephropathies can result in nephrotic syndrome. Most commonly, minimal change disease is seen in children under the age of 10, while adults are more commonly found to have membranous nephropathy. Read More

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http://dx.doi.org/10.1155/2019/6840240DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6948327PMC
December 2019

Duodenal Neuroendocrine Tumour Presenting as GABA B Receptor Autoimmune Encephalitis.

Case Rep Neurol Med 2019 6;2019:3428918. Epub 2019 Dec 6.

Department of Neurology, Continental Hospital, Nanakrumguda, Financial District, 500032 Hyderabad, India.

GABA B receptor antibody positive autoimmune encephalitis is rarely seen in clinical practice. It is usually associated with small cell lung carcinoma, and occasionally with neuroendocrine tumour (NET) of lung. GABA B receptor antibody can be associated with other autoimmune antibodies like antinuclear antibody and antibody to Glutamic acid decarboxylase. Read More

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http://dx.doi.org/10.1155/2019/3428918DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6942711PMC
December 2019

Mitochondrial Neurogastrointestinal Encephalomyopathy: Novel Pathogenic Mutation in Thymidine Phosphorylase Gene in a Patient from Cape Verde Islands.

Case Rep Neurol Med 2019 11;2019:5976410. Epub 2019 Dec 11.

Department of Neurology, Department of Neurosciences and Mental Health, Hospital de Santa Maria, Centro Hospitalar Universitário Lisboa Norte, Lisbon, Portugal.

Mitochondrial Neurogastrointestinal Encephalomyopathy (MNGIE) is a rare autosomal recessive disorder caused by mutations in the gene encoding the Thymidine Phosphorylase (TP). It is clinically characterized by severe gastrointestinal dysmotility, cachexia, palpebral ptosis, ophthalmoparesis, sensorimotor polyneuropathy and leukoencephalopathy. The diagnosis is established by the presence of typical clinical and neuroimaging features, positive family history, and abnormal genetic test. Read More

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http://dx.doi.org/10.1155/2019/5976410DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6927060PMC
December 2019

Successful Pallidal Deep Brain Stimulation Treatment in a Case of Generalized Dystonia due to a Novel Mutation.

Case Rep Neurol Med 2019 29;2019:3154653. Epub 2019 Nov 29.

Department of Neurology and Ophthalmology, Michigan State University, 804 Service Rd. B-411, East Lansing, MI 48824, USA.

Background: Dystonia is a ubiquitous syndrome, with a growing number of genes being continually identified. Mutations in the anoctamin-3 gene have been described to cause dystonia but the management and long-term outcomes are still largely unknown.

Methods: We present here a long term, longitudinal follow up of a patient with generalized dystonia, who was treated with bilateral pallidal deep brain stimulation and was found to harbor a mutation in the anoctamin-3 gene. Read More

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http://dx.doi.org/10.1155/2019/3154653DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6906865PMC
November 2019

The Spectrum of Acute Disseminated Encephalomyelitis and Mild Encephalopathy with Reversible Splenial Lesion.

Case Rep Neurol Med 2019 17;2019:9272074. Epub 2019 Oct 17.

Movement Disorders and Neurodegenerative Diseases Unit, Hospital Civil de Guadalajara "Fray Antonio Alcalde", Guadalajara, Mexico.

Background: Acute disseminated encephalomyelitis and mild encephalopathy with reversible splenial lesion are autoimmune demyelinating disorders of central nervous system. Diagnosis remains clinical, aided by neuroimaging confirmation and excluding other causes. In the absence of a biological marker, the diagnosis of these entities based on clinical and imaging criteria could overlap. Read More

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http://dx.doi.org/10.1155/2019/9272074DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6855051PMC
October 2019

Primary Angiitis of the Central Nervous System: From Psychiatry to Neurology.

Case Rep Neurol Med 2019 31;2019:8074258. Epub 2019 Oct 31.

REHAB Basel, Clinic for Neurorehabilitation and Paraplegiology, Basel, Switzerland.

We present a case of a 54-year-old man with primary angiitis of the central nervous system (PACNS) who was initially admitted to a psychiatric clinic with a diagnosis of delirium. We discuss the difficulty in establishing the diagnosis of PACNS and provide the reader with some recommendations on how to promptly and correctly diagnose this disease in order to avoid potentially lethal outcomes. Read More

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http://dx.doi.org/10.1155/2019/8074258DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6875412PMC
October 2019

Compressive Dorsal Myelopathy Secondary to Extramedullary Hematopoiesis in a Thalassemic Patient.

Case Rep Neurol Med 2019 17;2019:5827626. Epub 2019 Oct 17.

Department of Neurology, Ibn Sina Hospital, Kuwait.

Background: Extramedullary hematopoiesis (EMH) is one of the rare causes of spinal cord compression (SCC). It results from noncancerous proliferation of hematopoietic tissue outside the bone marrow as a compensatory mechanism for ineffective erythropoiesis. It occurs in the paraspinal area in 11-15% of thalassemic patients in intermediate and severe cases causing a paraspinal compressive mass. Read More

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http://dx.doi.org/10.1155/2019/5827626DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6855030PMC
October 2019

Central Pain Mimicking Trigeminal Neuralgia as a Result of Lateral Medullary Ischemic Stroke.

Case Rep Neurol Med 2019 27;2019:4235724. Epub 2019 Oct 27.

Lehigh Valley Physician Group - Neurology, Lehigh Valley Health Network, Allentown, PA, USA.

Background: Central pain mimicking trigeminal neuralgia (TN) as a result of lateral medullary infarction or Wallenberg syndrome has been rarely reported.

Case Report: We discuss a patient who presented with a lateral medullary infarct and shortly after developed facial pain mimicking TN. We also elaborate on the anatomical pathway of the trigeminal nerve explaining facial pain as a result of a lateral medullary lesion. Read More

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http://dx.doi.org/10.1155/2019/4235724DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6855040PMC
October 2019

Nilotinib-Induced Dystonia and Cognitive Deficits in a Neurologically Normal Patient with Chronic Myeloid Leukemia.

Case Rep Neurol Med 2019 12;2019:3679319. Epub 2019 Nov 12.

Department of Neurology, Barrow Neurological Institute, St. Joseph's Hospital and Medical Center, Phoenix, AZ, USA.

Nilotinib is a tyrosine kinase inhibitor used to treat patients with chronic myeloid leukemia (CML). This agent is also being studied in neurodegenerative disorders including Parkinson disease. Studies have shown that nilotinib may decrease the accumulation of parkin substrates and decrease the loss of dopaminergic cells. Read More

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http://dx.doi.org/10.1155/2019/3679319DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6875312PMC
November 2019

Utility of Botulinum Injections in Stiff-Person Syndrome.

Case Rep Neurol Med 2019 7;2019:9317916. Epub 2019 Oct 7.

Department of Neurology, Valley Hospital Medical Center, Las Vegas, NV, USA.

Stiff-person syndrome (SPS) is an uncommon neurological disorder characterized by significant rigidity and muscle spasms primarily affecting the truncal and proximal musculature. Furthermore, a wide-based gait with functional impairment is generally seen. High-dose benzodiazepines or baclofen are widely considered the optimal initial therapy; however, major adverse effects often preclude adequate dosing. Read More

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http://dx.doi.org/10.1155/2019/9317916DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6800926PMC
October 2019

Neurogenic Pulmonary Edema Following a Seizure: A Case Report and Literature Review.

Case Rep Neurol Med 2019 9;2019:6867042. Epub 2019 Oct 9.

Department of Internal Medicine, Hamad Medical Corporation, Doha, Qatar.

Acute pulmonary edema is one of the frequent causes of dyspnea encountered in everyday practice. It is broadly attributed to be either cardiogenic or noncardiogenic. It is usually treated with diuretics in addition to other medications depending on the underlying pathology. Read More

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http://dx.doi.org/10.1155/2019/6867042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6803739PMC
October 2019

Acute Partial Brown-Séquard Syndrome Secondary to Intraforaminal Disc Prolapse and Spinal Cord Infarction.

Case Rep Neurol Med 2019 25;2019:7987038. Epub 2019 Sep 25.

Department of Radiology and Medical Imaging, AHEPA University Hospital, Panepistimioupoli, 54124 Thessaloniki, Greece.

We report the case of a 45-year-old female who presented with acute left abdominal pain and subsequently developed a left partial Brown-Séquard syndrome. Spinal fluid, inflammatory and prothrombotic tests were unremarkable. Magnetic resonance showed a left intraforaminal disc prolapse at the T9-T10 level and a hyperintense lesion on T2-weighted images in the left postero-lateral cord at the T8-T9 level with restricted diffusion on DWI imaging. Read More

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http://dx.doi.org/10.1155/2019/7987038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6778944PMC
September 2019
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A Rare Case of Cyclophosphamide-Induced Posterior Reversible Encephalopathy Syndrome in a Patient with Anti-GBM Vasculitis, and Review of Current Literature.

Case Rep Neurol Med 2019 29;2019:2418597. Epub 2019 Sep 29.

Rutgers New Jersey Medical School, Newark, USA.

Posterior reversible encephalopathy syndrome (PRES) is a clinical syndrome of headache, altered mental status, and seizures with reversible mainly posterior leukoencephalopathy on neuroimaging. Precipitating factors for PRES are multifactorial and include autoregulatory failure due to changes in blood pressure, metabolic derangements, and cytotoxic medications. We report the second case of cyclophosphamide-induced PRES in a patient with anti-glomerular basement membrane (Anti-GBM) positive vasculitis. Read More

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http://dx.doi.org/10.1155/2019/2418597DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6791264PMC
September 2019
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Successful Clipping of a Giant Anterior Inferior Cerebellar Artery Aneurysm with Combined Transpetrosal Approach.

Case Rep Neurol Med 2019 18;2019:6049573. Epub 2019 Sep 18.

Institute for Preventive Medicine and Public Health, Hanoi Medical University, Hanoi, Vietnam.

Background: The anterior inferior cerebellar artery (AICA) aneurysms are rare lesions whose treatment can be challenging. There are only a few previous reports of surgical treatment for such lesions.

Objectives: We present a case of a basilar-AICA aneurysm undergoing surgery with the combined transpetrosal approach. Read More

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http://dx.doi.org/10.1155/2019/6049573DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6766670PMC
September 2019
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A First Case Report of Subependymoma in Mutation-Associated Noonan Syndrome.

Case Rep Neurol Med 2019 16;2019:6091059. Epub 2019 Sep 16.

Division of Neurology, Department of Pediatrics, Phramongkutklao Hospital and Phramongkutklao College of Medicine, Bangkok, Thailand.

Noonan syndrome (NS) is an autosomal dominant disorder in some cases caused by mutations. Since somatic mutations in are seen in several tumor types, NS which causes germline mutations are also increase the risk of hematologic malignancies and brain solid tumors. However, the report of brain tumors in Noonan syndrome remains rather rare. Read More

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http://dx.doi.org/10.1155/2019/6091059DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6766114PMC
September 2019

Hemorrhagic Stroke in a Young Adult with Undiagnosed Asymptomatic Dandy-Walker Malformation.

Case Rep Neurol Med 2019 17;2019:1450703. Epub 2019 Sep 17.

Kendall Regional Medical Center, Miami, FL 33175, USA.

The Dandy-Walker Malformation was first described in 1914 by Dandy and Blackfan and is characterized by hypoplasia of the vermis, pseudocystic fourth ventricle, upward displacement of the tentorium, torcular and lateral sinuses, and anteroposterior enlargement of the posterior fossa. This syndrome commonly manifests as hydrocephalus in children, though rare adult cases have been reported. The literature reveals adult symptomatology including brainstem infarction, psychosis, and neuromuscular disease. Read More

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http://dx.doi.org/10.1155/2019/1450703DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6766112PMC
September 2019
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A Case of Reverse Takotsubo Cardiomyopathy Incited by a Spinal Subdural Hematoma.

Case Rep Neurol Med 2019 22;2019:9285460. Epub 2019 Jul 22.

Florida Hospital, 601 E Rollins Street, Orlando, FL 32803, USA.

Takotsubo cardiomyopathy is a rare syndrome of transient, reversible left ventricular systolic dysfunction. It mimics myocardial infarction clinically and includes elevated cardiac enzymes, but echocardiography reveals apical ballooning and basal hyperkinesis. Infrequently, midventricular or even reverse Takotsubo patterns have been described, involving ballooning of the basal heart without the characteristic 'Takotsubo' appearance. Read More

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http://dx.doi.org/10.1155/2019/9285460DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6679891PMC
July 2019
9 Reads

Exercise Combined with Electrotherapy Enhances Motor Function in an Adolescent with Spinal Muscular Atrophy Type III.

Case Rep Neurol Med 2019 22;2019:4839793. Epub 2019 Jul 22.

Center for Neuromuscular Diseases and Neuropathies, Unit of Neurology, ASST "Spedali Civili", University of Brescia, Brescia, Italy.

Background: Electrotherapy is widely used in physical therapy to increase muscle mass, improve motor function, and assist physical activity in several neurologic conditions. However, concerning Spinal Muscular Atrophy (SMA), limited evidence exists on the role of electrotherapy as an adjunct for improving muscle strength and function.

Case Report: An adolescent (13 y. Read More

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http://dx.doi.org/10.1155/2019/4839793DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6679856PMC
July 2019
4 Reads

Cerebral Ischemia due to Aortic Arch Thrombosis Secondary to Iron Deficiency Anemia.

Case Rep Neurol Med 2019 18;2019:8647126. Epub 2019 Jul 18.

Department of Neurology, Rutgers New Jersey Medical School, Newark, New Jersey, USA.

Thrombocytosis, hypercoagulable state, and hypoxia secondary to anemia are some of the mechanisms that are thought to cause strokes in patients with iron deficiency anemia (IDA). Several cases of middle-aged females with IDA who had embolic strokes due to aortic arch thrombosis have been reported. Majority of the cases were treated with anticoagulation. Read More

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http://dx.doi.org/10.1155/2019/8647126DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6668537PMC
July 2019
7 Reads

Successful Extracorporeal Membrane Oxygenation (ECMO) Use without Systemic Anticoagulation for Acute Respiratory Distress Syndrome in a Patient with Aneurysmal Subarachnoid Hemorrhage.

Case Rep Neurol Med 2019 10;2019:9537453. Epub 2019 Jul 10.

Department of Anesthesiology, N-202 UKMC, 800 Rose Street, Lexington, KY 40536, USA.

Extracorporeal membrane oxygenation (ECMO) is an important life-saving technology for patients with severe acute respiratory distress syndrome (ARDS). Unfortunately, ECMO has been traditionally contraindicated in patients with hemorrhagic neurologic diseases. The recent improvement in ECMO devices, increased utilization and experience with venovenous ECMO technologies among healthcare teams, and the use of ECMO without anticoagulation has expanded the potential populations that may benefit from ECMO. Read More

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http://dx.doi.org/10.1155/2019/9537453DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6652035PMC
July 2019
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Orthographic Visualisation Induced Brain Activations in a Chronic Poststroke Global Aphasia with Dissociation between Oral and Written Expression.

Case Rep Neurol Med 2019 2;2019:8425914. Epub 2019 Jul 2.

Neurology Unit, Department of Neuro and Movement Sciences, Faculty of Science and Medicine, Fribourg University, Switzerland.

We propose a method of orthographic visualisation strategy in a poststroke severe aphasia person with dissociation between oral and written expression. fMRI results suggest that such strategy may induce the engagement of alternative nonlanguage networks and visual representations may help improving oral output. This choice of rehabilitation method can be based on the remaining capacities and, therefore, on written language. Read More

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http://dx.doi.org/10.1155/2019/8425914DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6632504PMC
July 2019
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Variants as Cause of Hereditary Spastic Paraplegia Type 76.

Case Rep Neurol Med 2019 1;2019:7615605. Epub 2019 Jul 1.

Tecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud, Monterrey, Nuevo Leon, Mexico.

Background: Autosomal recessive hereditary spastic paraplegias (HSP) are a rare group of hereditary neurodegenerative disorders characterized by spasticity with or without other symptoms. gene is the most common cause of autosomal recessive HSP. We report a case of autosomal recessive spastic paraplegia type 76 due to heterozygous variants of in an Argentinean subject. Read More

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http://dx.doi.org/10.1155/2019/7615605DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6634065PMC
July 2019
4 Reads

Lambert-Eaton Myasthenic Syndrome Secondary to Nivolumab and Ipilimumab in a Patient with Small-Cell Lung Cancer.

Case Rep Neurol Med 2019 2;2019:5353202. Epub 2019 Jul 2.

Department of Internal Medicine, Overlook Medical Center, Summit, NJ 07901, USA.

We present a case of a 59-year-old male with a confirmed diagnosis of small-cell lung cancer (SCLC). He had progressive disease even after four cycles of cisplatin and etoposide chemotherapy and 21 cycles of radiation. He was therefore started on immunotherapy with nivolumab every 2 weeks and ipilimumab every 6 weeks. Read More

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http://dx.doi.org/10.1155/2019/5353202DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6633879PMC
July 2019
3 Reads

Slightly Symptomatic Cerebral Amyloid Angiopathy-Related Inflammation with Spontaneous Remission in Four Months.

Case Rep Neurol Med 2019 4;2019:5308208. Epub 2019 Jul 4.

Department of Neurology, International University of Health and Welfare Hospital, 537-3, Iguchi, Nasushiobara, Tochigi 329-2763, Japan.

Cerebral amyloid angiopathy-related inflammation (CAA-ri) is a rare variant of CAA with autoimmune inflammation. A 77-year-old female experienced light-headedness during walking and mild ataxic gait without any other objective neuropsychological deficits. Brain magnetic resonance imaging (MRI) revealed an area of abnormal signal and mild parenchymal swelling in the right parietal lobe, indicating vasogenic edema. Read More

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http://dx.doi.org/10.1155/2019/5308208DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6637666PMC
July 2019
1 Read