288 results match your criteria Case reports in nephrology[Journal]


Acute Kidney Injury due to Anticoagulant-Related Nephropathy : A Suggestion for Therapy.

Case Rep Nephrol 2020 8;2020:8952670. Epub 2020 Jun 8.

O. U. of Nephrology, ASST Spedali Civili Brescia, Brescia, Italy.

The relationship between kidneys and anticoagulation is complex, especially after introduction of the direct oral anticoagulants (DOAC). It is recently growing evidence of an anticoagulant-related nephropathy (ARN), a form of acute kidney injury caused by excessive anticoagulation. The pathogenesis of kidney damage in this setting is multifactorial, and nowadays, there is no established treatment. Read More

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http://dx.doi.org/10.1155/2020/8952670DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7298278PMC

A Case of Systemic Lupus Erythematosus/Antineutrophil Cytoplasmic Antibody-Associated Vasculitis Overlap Syndrome with Dissociated Pathological and Immunological Findings.

Case Rep Nephrol 2020 15;2020:5698708. Epub 2020 May 15.

Division of Nephrology and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan.

Systemic lupus erythematosus/antineutrophil cytoplasmic antibody-associated vasculitis overlap syndrome (SLE/AAV OS) describes a pathological condition that presents with overlapping features of two diseases. There have been few reports of SLE/AAV OS and none from Japan. We present the case of a 59-year-old woman admitted with chief complaints of fever and decreased renal function. Read More

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http://dx.doi.org/10.1155/2020/5698708DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7246398PMC

The Association of TNF-Alpha Inhibitors and Development of IgA Nephropathy in Patients with Rheumatoid Arthritis and Diabetes.

Case Rep Nephrol 2020 20;2020:9480860. Epub 2020 Apr 20.

Department of Immunology and Rheumatology, University Hospital Centre Zagreb, Kispaticeva 12, Zagreb 10 000, Croatia.

IgA nephropathy (IgAN) is a rather uncommon complication of TNF-alpha inhibition with a range of findings such as asymptomatic microscopic/macroscopic hematuria or different degrees of proteinuria and could progress to end-stage renal disease. We are reporting three patients with longstanding rheumatoid arthritis (RA), which developed IgAN while receiving TNF-alpha inhibitors. All off our three patients had RA, which lasted 2-4 years, and none of them had a prior history of chronic kidney disease. Read More

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http://dx.doi.org/10.1155/2020/9480860DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7191367PMC

Angiosarcoma of an Arteriovenous Fistula for Hemodialysis in a Kidney Transplant Recipient Affected by Lowe's Syndrome.

Case Rep Nephrol 2020 13;2020:9734635. Epub 2020 Apr 13.

Università Cattolica del Sacro Cuore, Rome, Italy.

. To describe an uncommon, life-threatening condition such as angiosarcoma of a fistula for hemodialysis occurring in a transplant recipient affected by Lowe's syndrome. . Read More

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http://dx.doi.org/10.1155/2020/9734635DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7174910PMC

Acute Kidney Injury Caused by Superior Mesenteric Artery Syndrome.

Case Rep Nephrol 2020 9;2020:8364176. Epub 2020 Apr 9.

Nephrology Unit, Medical Department, National University of Malaysia Medical Centre, Kuala Lumpur, Malaysia.

Background: Superior mesenteric artery (SMA) syndrome is a rare cause of upper gastrointestinal obstruction leading to acute kidney injury (AKI).

Methods: We report a case of 23-year-old army personnel who presented with persistent vomiting leading to severe hypokalaemia, metabolic alkalosis, and acute kidney injury resulting in cardiorespiratory arrest.

Results: After successful resuscitation, he was supported with haemodialysis and aggressive electrolytes correction. Read More

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http://dx.doi.org/10.1155/2020/8364176DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7171609PMC

Fibrillary Glomerulopathy with a High Level of Myeloperoxidase-ANCA: A Case Report.

Case Rep Nephrol 2020 23;2020:6343521. Epub 2020 Mar 23.

Department of Internal Medicine, Suwa Central Hospital, Chino, Nagano 391-8503, Japan.

An elderly woman was admitted with the chief complaint of gross hematuria. Laboratory values indicated a high myeloperoxidase-ANCA level. In renal histological examination, 40% of the glomeruli showed crescent formation, but immunofluorescence staining showed positivity for IgG, C3, and C1q. Read More

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http://dx.doi.org/10.1155/2020/6343521DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7128069PMC

Osmotic Demyelination Syndrome in a Patient with Hypokalemia but No Hyponatremia.

Case Rep Nephrol 2020 23;2020:3618763. Epub 2020 Mar 23.

Radiology Department, Hospital do Divino Espírito Santo, Ponta Delgada, Portugal.

Osmotic demyelination syndrome (ODS) is characterized by loss of myelin in various parts of the central nervous system. It is mainly caused by a rapid correction of hyponatremia, although other factors that may cause rapid rise in serum osmolality can also be associated with its development. Its prognosis is poor and the recovery rate is unknown. Read More

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http://dx.doi.org/10.1155/2020/3618763DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7125463PMC

Temporal Arteritis and Vision Loss in Microscopic Polyangiitis: A Case Report and Literature Review.

Case Rep Nephrol 2020 26;2020:1426401. Epub 2020 Mar 26.

Penn Medicine Princeton Medical Center, Princeton Hypertension and Nephrology, 1 Plainsboro Rd, Plainsboro Township, NJ 08536, USA.

Microscopic polyangiitis (MPA) is an idiopathic autoimmune disease characterized by systemic vasculitis. While the lungs and kidneys are the major organs affected by MPA, it is known to involve multiple organ systems throughout the body. Temporal artery involvement is a very rare finding in MPA. Read More

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http://dx.doi.org/10.1155/2020/1426401DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7136809PMC

Liberation from Dialysis Dependence in a Patient with HIV-Associated Nephropathy (HIVAN) after Combined Antiretroviral Therapy (cART).

Case Rep Nephrol 2020 15;2020:7294765. Epub 2020 Mar 15.

Division of Nephrology, University of Florida, Jacksonville, FL, USA.

Prior to the advent of combined antiretroviral therapy (cART), human immunodeficiency virus-associated nephropathy (HIVAN) was inevitably associated with rapidly progressive renal failure and dialysis dependence. HIV-1 seropositive patients often met with untimely deaths due to complications of end-stage renal disease (ESRD), opportunistic infections, or other HIV-related end-organ failure. Although the association between cART and improved outcomes in HIVAN has been recognized for over 20 years, no randomized trials have specifically examined this effect to date. Read More

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http://dx.doi.org/10.1155/2020/7294765DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7102486PMC

Anterior Ischemic Optic Neuropathy in a Child Receiving Chronic Hemodialysis.

Case Rep Nephrol 2020 16;2020:7012586. Epub 2020 Mar 16.

Division of Nephrology, Department of Pediatrics, McMaster Children's Hospital, Hamilton, Ontario, Canada.

Anterior ischemic optic neuropathy (AION) occurs due to hypoperfusion of the optic nerve and is a rare complication in patients receiving maintenance dialysis. To date, AION has only been reported in 22 children, all of whom were receiving peritoneal dialysis. We report the first case of AION in a 2-year 11-month-old child receiving chronic hemodialysis secondary to polycystic kidney disease from a phosphomannomutase 2 gene mutation. Read More

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http://dx.doi.org/10.1155/2020/7012586DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7102483PMC

Membranoproliferative Glomerulonephritis Associated with Nivolumab Therapy.

Case Rep Nephrol 2020 24;2020:2638283. Epub 2020 Feb 24.

Department of Internal Medicine, Division of Nephrology, University of California at Davis, Sacramento, CA, USA.

Nivolumab is an immune checkpoint inhibitor that targets programmed death-1 on T cells and is designed to amplify an immunologic reaction against cancer cells. However, upregulation of the immune system with checkpoint inhibition is nonspecific, and it can be associated with certain renal side effects, the best documented of which is acute tubulointerstitial nephritis. We present a unique case of a patient with acute kidney injury associated with nephrotic syndrome shortly after starting nivolumab therapy for metastatic anal carcinoma. Read More

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http://dx.doi.org/10.1155/2020/2638283DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7060432PMC
February 2020

The Various Forms of Nephrotic Syndrome in a Patient with Systemic Lupus Erythematosus.

Case Rep Nephrol 2020 13;2020:7869216. Epub 2020 Feb 13.

Nephrology Department and Transplantation Unit, Laiko Hospital, National & Kapodistrian University of Athens, Faculty of Medicine, Athens, Greece.

Kidney involvement is frequent in patients with systemic lupus erythematosus (SLE), although it may not be present from disease onset. Renal lupus itself is highly heterogenous with respect to the combination and/or severity of clinical and/or laboratory manifestations. This is a case of a 45-year-old Caucasian female with an established diagnosis of SLE, who presented four times with new onset of proteinuria during a follow-up time of ten years, since the diagnosis of SLE. Read More

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http://dx.doi.org/10.1155/2020/7869216DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7040396PMC
February 2020

Amlodipine-Induced Gingival Hyperplasia in a Young Male with Stage 5 Chronic Kidney Disease.

Case Rep Nephrol 2020 12;2020:7801546. Epub 2020 Feb 12.

Department of Medicine, Christian Medical College, Vellore, India.

Gingival hyperplasia is a rare finding in clinical practice. Nevertheless, when it occurs, it is a finding of great value as it can lead to definite clinical diagnosis. The present case is a 19-year-old male who was referred for further management of stage 5 chronic kidney disease. Read More

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http://dx.doi.org/10.1155/2020/7801546DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7038384PMC
February 2020

Clinicopathological Implications of Proteinuria after Long-Term Isolated Hematuria due to Thin Basement Membrane Nephropathy and Focal Segmental Glomerulosclerosis.

Case Rep Nephrol 2019 17;2019:1627392. Epub 2019 Dec 17.

Department of Internal Medicine, Teikyo University School of Medicine, Itabashi-ku, Tokyo, Japan.

A 45-year-old obese man presented with persistent hematuria for 21 years. At the age of 37, he developed hypertension and proteinuria which later increased up to 1.6 g/g creatinine. Read More

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http://dx.doi.org/10.1155/2019/1627392DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6959157PMC
December 2019

A Case Report on Peritoneal Dialysis-Associated Peritonitis: When Cats Think Medical Equipment Are Toys.

Case Rep Nephrol 2019 9;2019:5150695. Epub 2019 Dec 9.

Alabama College of Osteopathic Medicine, 445 Health Sciences Blvd, Dothan, AL 36303, USA.

is an aerobic gram-negative coccobacillus usually found in the oral cavities of most healthy cats and dogs as part of their natural oral flora. This zoonotic pathogen can cause a variety of infections in humans through bites, scratches, or licking. Infections range from less severe cases, such as infected animal bites and cellulitis, to more severe cases of pneumonia, septic arthritis, osteomyelitis, sepsis, and meningitis. Read More

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http://dx.doi.org/10.1155/2019/5150695DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6942743PMC
December 2019

Intravitreal Injection of Anti-VEGF Antibody Induces Glomerular Endothelial Cells Injury.

Case Rep Nephrol 2019 21;2019:2919080. Epub 2019 Dec 21.

Department of Nephrology and Dialysis, Centre Hospitalier Universitaire, Hospital Brugmann, Brussels, Belgium.

Introduction: Antiangiogenic agents that inhibit vascular endothelial growth factor have emerged as important tools in cancer therapy and ocular diseases. Their systemic use can induce renal limited microangiopathy. Local use of anti-VEGF agent is supposed to be safe. Read More

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http://dx.doi.org/10.1155/2019/2919080DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6942715PMC
December 2019

Two Cases of the Disorder Fechtner Syndrome Diagnosed from Observation of Peripheral Blood Cells before End-Stage Renal Failure.

Case Rep Nephrol 2019 26;2019:5149762. Epub 2019 Nov 26.

Department of Nephrology and Hypertension, Sumitomo Hospital, 5-3-20 Nakanoshima, Kita-ku, Osaka 530-0005, Japan.

As a disorder, Fechtner syndrome is characterized by nephritis, giant platelets, granulocyte inclusion bodies (Döhle-like bodies), cataract, and sensorineural deafness. Observation of peripheral blood smear for the presence of thrombocytopenia, giant platelets, and granulocyte inclusion bodies (Döhle-like bodies) is highly important for the early diagnosis of disorders. In our two cases, sequencing analysis of the gene indicated mutations in exon 24. Read More

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http://dx.doi.org/10.1155/2019/5149762DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6899327PMC
November 2019

Cabazitaxel Induced Thrombotic Microangiopathy in a Patient with Prostate Cancer.

Case Rep Nephrol 2019 19;2019:8591283. Epub 2019 Nov 19.

Groupe Hospitalier Sud Ile-De-France, Centre Hospitalier de Melun, 77000 Melun, France.

Cancer-associated thrombotic microangiopathy (TMA) refers to a group of disorders characterized by microangiopathic haemolytic anemia, thrombocytopenia, and ischemic organ damage. TMA manifestations can be induced by cancer or by chemotherapy. We report the case of a 64-year-old man with metastatic prostate cancer who experienced a Cabazitaxel-induced TMA manifestation. Read More

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http://dx.doi.org/10.1155/2019/8591283DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6885798PMC
November 2019

Acute Kidney Injury Secondary to Necrotizing Sarcoid Granulomatosis.

Case Rep Nephrol 2019 5;2019:3736495. Epub 2019 Nov 5.

Department of Nephrology, Sri Ramachandra Institute of Higher Education and Research, Chennai, India.

Background: Sarcoidosis is a chronic disease characterized by noncaseating lesions involving any organ and tissue in the body. Hypercalcemia and acute kidney injury is a common renal presentation of sarcoidosis. Necrotizing sarcoid granulomatosis (NSG) is a granulomatous disease entity which presents with nodular masses of sarcoid like granuloma which primarily effects the lungs. Read More

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http://dx.doi.org/10.1155/2019/3736495DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6875228PMC
November 2019

Henoch-Schönlein Nephritis Manifesting with Purpura 15 years after Diagnosis of IgA Nephropathy.

Case Rep Nephrol 2019 29;2019:1042648. Epub 2019 Oct 29.

Department of Nephrology, Hirosaki University Hospital, Hirosaki, Japan.

Henoch-Schönlein nephritis or immunoglobulin A (IgA) vasculitis is characterized by purpura, arthralgia, abdominal pain, and glomerulonephritis with glomerular IgA deposition. Notably, the presence of purpura is essential to diagnose this disease. We report the case of a patient in whom proteinuria and haematuria were detected during screening tests and he was diagnosed with IgA nephropathy at 20 years of age. Read More

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http://dx.doi.org/10.1155/2019/1042648DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6854950PMC
October 2019

Severe Hypocalcemia and Resulting Seizure Caused by Vitamin D Deficiency in an Older Patient Receiving Phenytoin: Eldecalcitol and Maxacalcitol Ointment as Potential Therapeutic Options for Hypocalcemia.

Case Rep Nephrol 2019 15;2019:3653276. Epub 2019 Oct 15.

Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

An 82-year-old man treated with phenytoin for the prevention of symptomatic epilepsy was hospitalized to treat consciousness disturbance, seizure, and hypocalcemia (serum calcium: 4.6 mg/dL). Serum 25-hydroxyvitamin D level was very low (5. Read More

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http://dx.doi.org/10.1155/2019/3653276DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6815596PMC
October 2019

Apheresis Therapy for Steroid-Resistant Idiopathic Nephrotic Syndrome: Report on a Case Series.

Case Rep Nephrol 2019 9;2019:7304786. Epub 2019 Oct 9.

Service de Néphrologie, Hémodialyse, Aphérèses et Transplantation Rénale, CHU Grenoble-Alpes, Grenoble, France.

Idiopathic nephrotic syndrome (INS) represents 15%-30% of adulthood glomerulopathies. Corticosteroids have been the main treatment for decades and are effective in 70% of minimal-change disease patients and ~30% of focal segmental glomerulosclerosis patients. Multidrug-resistant (steroids, calcineurin-inhibitors, cyclophosphamide, mycophenolate-mofetil, rituximab) idiopathic nephrotic syndrome is a major therapeutic challenge in nephrology. Read More

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http://dx.doi.org/10.1155/2019/7304786DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6803719PMC
October 2019

Successful Subsequent Pregnancy in a Woman Receiving Eculizumab for Pregnancy-Associated Atypical Haemolytic Uraemic Syndrome.

Case Rep Nephrol 2019 7;2019:2738723. Epub 2019 Oct 7.

Central and Northern Adelaide Renal and Transplantation Service (CNARTS), Royal Adelaide Hospital, Adelaide, Australia.

Atypical haemolytic uraemic syndrome (aHUS) is a form of thrombotic microangiopathy precipitated by unopposed complement activation, the treatment of which has been revolutionised by the availability of the monoclonal anti-complement (C5) antibody, eculizumab. Historically, women with aHUS would be unable to achieve a successful pregnancy due to the severity of their renal disease and for the few who could conceive, recurrence of aHUS was a significant risk. In spite of this, parenthood remains a priority for many. Read More

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http://dx.doi.org/10.1155/2019/2738723DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6800934PMC
October 2019
1 Read

Propofol Infusion Syndrome in the Postoperative Period of a Kidney Transplant.

Case Rep Nephrol 2019 25;2019:7498373. Epub 2019 Sep 25.

Department of Nephrology, Hospital General de México, Mexico City, Mexico.

Sedation during medical procedures poses a risk to any patient, and the use of specific anesthetic agents should be carefully considered to avoid adverse outcomes. We report on a patient with propofol infusion syndrome diagnosed during the post-operative period of a renal transplant. A 58-year-old female on chronic hemodialysis due to end stage kidney disease secondary to microscopic polyangiitis underwent kidney transplant from a deceased donor. Read More

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http://dx.doi.org/10.1155/2019/7498373DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6778882PMC
September 2019

Lanthanum-Induced Radiopaque Intestinal Precipitates: A Potential Cause of Intestinal Foreign Bodies.

Case Rep Nephrol 2019 2;2019:1298674. Epub 2019 Sep 2.

Jackson Memorial Hospital/University of Miami Hospital, Miami, FL, USA.

Lanthanum carbonate is a commonly prescribed oral phosphate binder for use in patients with acute or chronic kidney disease. The elemental form of lanthanum is a soft metal, which will appear radiopaque on a standard X-ray radiograph. This case report illustrates the potential for Lanthanum to masquerade as multiple radiopaque intestinal foreign bodies, leading to the extensive mobilization of medical resources and consultations including serial X-ray monitoring, multiple consultants including acute care and colorectal surgery. Read More

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http://dx.doi.org/10.1155/2019/1298674DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6745136PMC
September 2019

Corrigendum to "Pericardial Tamponade: An Uncommon Clinical Presentation in cANCA Related Vasculitis and Glomerulonephritis in Association with Very High Titres of ANA".

Case Rep Nephrol 2019;2019:6703652. Epub 2019 Aug 22.

Department of Nephrology, Eastern Virginia Medical School, 855 W Brambleton Ave., Norfolk, VA 23510, USA.

[This corrects the article DOI: 10.1155/2019/4983139.]. Read More

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http://dx.doi.org/10.1155/2019/6703652DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6724443PMC
August 2019
1 Read

Lymphoma-Associated Monoclonal Cryoglobulinemic Glomerulonephritis and Relationship with Hepatitis C Virus Infection: A Case Report.

Case Rep Nephrol 2019 18;2019:7940291. Epub 2019 Aug 18.

Department of Internal Medicine, University of Texas Medical Branch, Galveston, TX, USA.

We report a case of type I cryoglobulinemic glomerulonephritis in a patient with chronic hepatitis C who presented with acute renal failure. The renal biopsy revealed membranoproliferative GN (MPGN) due to cryoglobulinemia with unexpected monoclonal Kappa restriction on immunofluorescence microscopy, suggesting an underlying hematopoietic malignancy. The bone marrow biopsy revealed presence of marginal zone lymphoma. Read More

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http://dx.doi.org/10.1155/2019/7940291DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6719345PMC
August 2019
6 Reads

The Black Esophagus in the Renal Transplant Patient.

Case Rep Nephrol 2019 25;2019:5085670. Epub 2019 Jul 25.

Emory University, Division of Digestive Diseases, USA.

Acute esophageal necrosis (AEN) is an uncommon disease characterized by gastrointestinal bleeding and endoscopic findings of circumferential black-colored necrosis of the distal esophagus. Patients at risk include elderly males over the age of 65, who typically have multiple chronic medical issues including vascular disease and diabetes. Mortality is reported to be 32%. Read More

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http://dx.doi.org/10.1155/2019/5085670DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6683813PMC

Deterioration in Clinical Status Is Not Enough to Suspend Eculizumab: A Genetic Complement-Mediated Atypical Hemolytic Uremic Syndrome Case Report.

Case Rep Nephrol 2019 9;2019:9264824. Epub 2019 Jul 9.

U.O.C. Nefrologia, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.

Background: Atypical hemolytic uremic syndrome (aHUS) is characterized by microangiopathic hemolytic anemia, thrombocytopenia, and renal failure. Mutations in CFI gene coding for complement regulation factors and in THBD gene coding for endothelial cell receptor thrombomodulin could predispose to the disease and hypertension can trigger the onset.

Case Presentation: A 51-year-old female patient who had received kidney transplant eighteen years ago presented with hypertensive peak and hemolysis pattern. Read More

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http://dx.doi.org/10.1155/2019/9264824DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6652041PMC
July 2019
11 Reads

Ketogenic Diet-Induced Severe Ketoacidosis in a Lactating Woman: A Case Report and Review of the Literature.

Case Rep Nephrol 2019 8;2019:1214208. Epub 2019 Jul 8.

Berkshire Medical Center, Pittsfield, MA 01201, USA.

The ketogenic diet (KD) is a high-fat, adequate-protein, and low-carbohydrate diet that leads to nutritional ketosis and weight loss. It is known to induce ketosis but is not an established cause of clinically significant ketoacidosis. Lactation ketoacidosis is well established in bovine literature but remains a rare phenomenon in humans. Read More

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http://dx.doi.org/10.1155/2019/1214208DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6644245PMC
July 2019
2 Reads

Calciphylaxis: Successful Management of a Rare Complication of Chronic Kidney Disease in Two Patients.

Case Rep Nephrol 2019 17;2019:1630613. Epub 2019 Jun 17.

Nephrology Dialysis and Transplantation Department, Ibn Sina Teaching Hospital, Rabat, Morocco.

Calciphylaxis, or calcification uremic arteriolopathy, is a rare disease thought to occur due to arteriolar calcifications of the dermis and is responsible for ischemia with cutaneous necrosis and painful panniculitis. Its mechanism remains poorly understood which makes its management challenging and difficult to standardize. We report our management of two patients diagnosed with calciphylaxis. Read More

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http://dx.doi.org/10.1155/2019/1630613DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6601500PMC
June 2019
4 Reads

Pericardial Tamponade: An Uncommon Clinical Presentation in cANCA Related Vasculitis and Glomerulonephritis in Association with Very High Titres of ANA.

Case Rep Nephrol 2019 13;2019:4983139. Epub 2019 Jun 13.

Nephrology, Eastern Virginia Medical School, 855 W Brambelton Ave, Norfolk, VA 23510, USA.

ANCA (anti-neutrophil cytoplasmic antibody) vasculitides are systemic autoimmune diseases in which anti-neutrophilic cytoplasmic antibodies activate primed neutrophils, thereby generating an inflammatory cascade resulting in the damage of small sized blood vessels in various organs of the body, including the heart. Pleuropericardial involvement is underrecognized as a complication of ANCA vasculitis and is highlighted in this case report of a 51-year-old male who presented with an initial symptomatic presentation of pleuropericardial effusion progressing to pericardial tamponade in the setting of a later renal biopsy proven pauci-immune crescentic glomerulonephritis with high ANA titres along with positive cANCA (cytoplasmic ANCA) and PR3 (proteinase 3) antibodies. He was found to have acute renal failure which progressively got better with cyclophosphamide. Read More

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http://dx.doi.org/10.1155/2019/4983139DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6595352PMC
June 2019
3 Reads

Portal Vein Thrombosis in a 21-Year-Old Man with Membranoproliferative Glomerulonephritis and Nephrotic Syndrome.

Case Rep Nephrol 2019 28;2019:3409832. Epub 2019 May 28.

Department of Medicine, Nazarbayev University School of Medicine, Nur-Sultan, Kazakhstan.

Membranoproliferative glomerulonephritis, one of the main causes of nephrotic syndrome, is associated with a state of hypercoagulability that leads to increased risk of thrombotic events. Portosystemic collaterals may reopen due to reversal of the flow within the existing veins and be a presenting feature of thrombosis. We describe a patient who presented with large portosystemic collaterals and signs of portal hypertension and was subsequently found to be affected by membranous proliferative glomerulonephritis. Read More

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http://dx.doi.org/10.1155/2019/3409832DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6558605PMC
May 2019
6 Reads

Late Onset Graft Plasmacytoma-Like PTLD Presenting as Acute Hyperglycemia in a Kidney-Pancreas Transplant Recipient.

Case Rep Nephrol 2019 19;2019:2818074. Epub 2019 May 19.

Department of Nephrology and Renal Transplant, Hospital Clínic, Barcelona, Spain.

Allograft infiltration has been described in up to 20% of all patients with posttransplant lymphoproliferative disorder (PTLD), most representing EBV-positive B-cell lymphomas. Plasma cells are often observed in humoral rejection biopsies, but graft infiltration by plasmacytoma-like PTLD is rare. We report the case of a 54-year-old simultaneous pancreas-kidney transplant recipient (immunosuppression: OKT3, methylprednisolone, cyclosporine, and azathioprine), diagnosed with an IgG-kappa monoclonal gammopathy of undetermined significance eighteen years after transplant. Read More

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https://www.hindawi.com/journals/crin/2019/2818074/
Publisher Site
http://dx.doi.org/10.1155/2019/2818074DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6545763PMC
May 2019
6 Reads

Relapsed Acute Lymphoblastic Leukemia Presenting as Acute Renal Failure.

Case Rep Nephrol 2019 13;2019:7913027. Epub 2019 May 13.

Malignant Hematology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33602, USA.

Acute lymphoblastic leukemia (ALL) is the second most common acute leukemia in adults. It is an aggressive hematologic neoplasm, with a bimodal age distribution typically presenting in childhood and the 6 decade of life (Terwilliger and Abdul-Hay, 2017). Renal injury in ALL is common and can occur through many different mechanisms, such as prerenal acute kidney injury, acute tubular necrosis, renovascular disease, obstruction, glomerulonephritis, and parenchymal infiltration of tumor cells (Luciano and Brewster, 2014). Read More

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http://dx.doi.org/10.1155/2019/7913027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6535833PMC
May 2019
16 Reads

Incidentally Diagnosed Alport Syndrome in a Patient with Drug-Induced Vasculitis.

Case Rep Nephrol 2019 10;2019:8720837. Epub 2019 Apr 10.

Baylor College of Medicine, Houston, TX 77030, USA.

A 53-year-old woman is admitted with a serum creatinine of 16 mg/dl. Seven months earlier, she was diagnosed with heart failure and started on several medications, including Hydralazine. Laboratory studies revealed the presence of dual Anti-Neutrophil Cytoplasmic Antibodies (anti-MPO and anti-PR3), anti-nuclear and anti-histone antibodies. Read More

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http://dx.doi.org/10.1155/2019/8720837DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6481119PMC
April 2019
5 Reads

Severe Hypocalcemia and Dramatic Increase in Parathyroid Hormone after Denosumab in a Dialysis Patient: A Case Report and Review of the Literature.

Case Rep Nephrol 2019 21;2019:3027419. Epub 2019 Mar 21.

Department of Internal Medicine, Wayne State University, Detroit, MI, USA.

Chronic kidney disease-mineral and bone disorder (CKD-MBD) is frequently present in advanced stages of chronic kidney disease (CKD) patients with high risk of fracture and elevated socioeconomic burden. Denosumab, an injectable human monoclonal antibody with affinity for nuclear factor-kappa ligand (RANKL), is an effective treatment for osteoporosis in postmenopausal women and men. Unlike the bisphosphonates, the pharmacokinetics and pharmacodynamics of denosumab are not influenced by the renal function and are being increasingly used for patients having CKD-MBD with low bone mineral density (BMD) to reduce the risk of fragility fractures. Read More

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https://www.hindawi.com/journals/crin/2019/3027419/
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http://dx.doi.org/10.1155/2019/3027419DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448326PMC
March 2019
10 Reads

Clinical Resolution of Osmotic Demyelination Syndrome following Overcorrection of Severe Hyponatremia.

Case Rep Nephrol 2019 20;2019:1757656. Epub 2019 Mar 20.

Saint Joseph's University Medical Center, USA.

Osmotic Demyelination Syndrome (ODS) occurs after rapid overcorrection of severe chronic hyponatremia usually in those with a predisposition such as chronic alcoholism, malnutrition, or liver disease. Rarely, do patients make a full recovery. We report a case of ODS secondary to overcorrection of severe hyponatremia with pathognomonic clinical and radiologic signs making a complete neurological recovery. Read More

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http://dx.doi.org/10.1155/2019/1757656DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446114PMC
March 2019
5 Reads

Treating TNF Receptor Associated Periodic Fever Syndrome in End-Stage Renal Failure.

Case Rep Nephrol 2019 17;2019:6819476. Epub 2019 Mar 17.

Hospital Amato Lusitano, Castelo Branco, Portugal.

Tumor necrosis factor receptor associated periodic syndrome (TRAPS) is a rare monogenic autoinflammatory disease. Its most severe manifestation is secondary amyloidosis. A 44-year-old male presented with nephrotic syndrome. Read More

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http://dx.doi.org/10.1155/2019/6819476DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441500PMC
March 2019
10 Reads

Multiple Faces of Chronic Lymphocytic Leukaemia: A Patient with Renal, Cardiac, and Skeletal Complications.

Case Rep Nephrol 2019 12;2019:5390235. Epub 2019 Mar 12.

Department of Renal Medicine, Norfolk and Norwich University Hospital, Norwich, UK.

We describe a patient who had chronic lymphocytic leukaemia (CLL) Binet stage A at presentation with further evidence of disease at multiple sites but who initially required no treatment. However, several years later, her peripheral blood lymphocyte count started to increase, and soon after that she suffered an acute myocardial infarct (in the absence of coronary atheroma) together with proteinuric renal failure due to membranoproliferative glomerulonephritis. Her renal function improved markedly following anti-CLL chemotherapy. Read More

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https://www.hindawi.com/journals/crin/2019/5390235/
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http://dx.doi.org/10.1155/2019/5390235DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434293PMC
March 2019
25 Reads

A Case of Rheumatoid Arthritis Presenting with Renal Thrombotic Microangiopathy Probably due to a Combination of Chronic Tacrolimus Arteriolopathy and Severe Hypertension.

Case Rep Nephrol 2019 6;2019:3923190. Epub 2019 Mar 6.

Department of Internal Medicine, Teikyo University School of Medicine, Itabashi-ku, Tokyo, Japan.

A 51-year-old woman with rheumatoid arthritis presented with mild hypertension 20 months after tacrolimus treatment and developing proteinuria 24 months after the treatment. Tacrolimus was discontinued 27 months after the treatment, followed by heavy proteinuria, accelerated hypertension, and deteriorating renal function without ocular fundus lesions as a clinical sign of malignant hypertension. Renal biopsy revealed malignant nephrosclerosis characterized by subacute and chronic thrombotic microangiopathy (TMA), involving small arteries, arterioles, and glomeruli. Read More

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http://dx.doi.org/10.1155/2019/3923190DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431373PMC
March 2019
13 Reads

Rapidly Progressive Glomerulonephritis Secondary to IgA Nephropathy in a Patient with Systemic Lupus Erythematosus.

Case Rep Nephrol 2019 5;2019:8354823. Epub 2019 Mar 5.

Department of Internal Medicine, Division of Nephrology, Houston, TX, USA.

Lupus nephritis is a common manifestation of systemic lupus erythematosus (SLE). IgA nephropathy is a common type of primary glomerulonephritis. Renal manifestations in SLE patients are often due to lupus nephritis; however, renal diseases unrelated to lupus nephritis are rarely reported. Read More

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https://www.hindawi.com/journals/crin/2019/8354823/
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http://dx.doi.org/10.1155/2019/8354823DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425374PMC
March 2019
22 Reads

Late-Onset Neutropenia after Rituximab Treatment for Adult-Onset Nephrotic Syndrome.

Case Rep Nephrol 2019 5;2019:3580941. Epub 2019 Mar 5.

Department of Nephrology, Tokyo Women's Medical University, Tokyo, Japan.

A 41-year-old woman developed nephrotic syndrome at the age of 32 and was diagnosed with minimal change nephrotic syndrome based on a renal biopsy. Although remission was achieved with administration of prednisolone (PSL) and cyclosporine, the nephrotic syndrome recurred. She was also started on rituximab (RTX). Read More

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http://dx.doi.org/10.1155/2019/3580941DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425356PMC
March 2019
9 Reads

Atypical Causes of Urinary Tract Obstruction.

Case Rep Nephrol 2019 27;2019:4903693. Epub 2019 Feb 27.

State University of New York, Downstate Medical Center, Brooklyn, NY 11203, USA.

Acute kidney injury due to urinary tract obstruction invariably suggests lower urinary tract obstruction or bilateral ureteric obstruction since obstruction of a single kidney while the contralateral kidney is normal and not obstructed would not cause a perceptible rise in creatinine. Assuming a total body volume of 42 L, 70 kg male that generates approximately 1400 mg of creatinine daily (20 mg/kg/day) who has complete urinary tract obstruction would experience a 3.33 mg/dL per day increase in serum creatinine. Read More

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http://dx.doi.org/10.1155/2019/4903693DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6415304PMC
February 2019
14 Reads

Successful Initiation of Dialysis with a 20-Year-Old Buried Peritoneal Dialysis Catheter: Case Report and Literature Review.

Case Rep Nephrol 2019 18;2019:5678026. Epub 2019 Feb 18.

Division of Nephrology, Department of Medicine, University of Ottawa and The Ottawa Hospital, Canada.

Buried peritoneal dialysis (PD) catheters are typically inserted several weeks or months before the anticipated need for dialysis. Occasionally, renal function unexpectedly stabilizes after the surgery, and a patient may go years before the catheter is needed. We report a case of successful initiation of PD with a twenty-year-old buried catheter. Read More

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http://dx.doi.org/10.1155/2019/5678026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6398044PMC
February 2019

Acute Kidney Failure in a Young African American Male.

Case Rep Nephrol 2019 17;2019:2591560. Epub 2019 Feb 17.

Olive View-UCLA Medical Center, Division of Nephrology and Hypertension, Los Angeles, CA 91342, USA.

Retroperitoneal fibrosis (RPF) is a condition characterized by chronic inflammatory and fibrotic changes in the retroperitoneum that can lead to serious complications including kidney failure, mesenteric and limb ischemia, and deep venous thrombosis among others. Affected individuals may present with nonspecific symptomology that would require a high clinical index of suspicion for prompt diagnosis. We herein discuss a case of a young African-American man with recurrent deep venous thrombosis who presents with a 4-week history of constant aching pain of abdomen and back and kidney failure. Read More

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https://www.hindawi.com/journals/crin/2019/2591560/
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http://dx.doi.org/10.1155/2019/2591560DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6398077PMC
February 2019
29 Reads

Radiologically Guided Renal Artery Embolization with an Amplatzer Vascular Plug as a Rescue Therapy for Refractory Nephrotic Syndrome in AL-Amyloidosis.

Case Rep Nephrol 2019 11;2019:5469712. Epub 2019 Feb 11.

Clinic for Transplant Immunology and Nephrology, University Hospital Basel, Switzerland.

Nephrotic syndrome is common in immunoglobulin light-chain (AL) amyloidosis and successful therapy may pose a challenge. We report the case of a 63-year-old patient with severe nephrotic syndrome due to primary renal AL-amyloidosis with well-preserved renal function at first presentation. Therapy with high dose steroids, loop diuretics, and ACE-inhibitors did not affect his proteinuria and he was seriously disabled because of symptomatic orthostatic hypotension and anasarca. Read More

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http://dx.doi.org/10.1155/2019/5469712DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6388347PMC
February 2019
3 Reads

Acute Uric Acid Nephropathy following Epileptic Seizures: Case Report and Review.

Case Rep Nephrol 2019 4;2019:4890287. Epub 2019 Feb 4.

Division of Pulmonary and Critical Care Medicine, Pikeville Medical Center, USA.

Acute hyperuricemia most commonly occurs in patients who experience tumor lysis syndrome. Hyperuricemia along with other electrolyte abnormalities like hyperkalemia, hypocalcemia, and hyperphosphatemia leads to acute kidney injury (AKI) due to acute uric acid nephropathy which is associated with significant morbidity. High risk patients are thus closely monitored for signs of these laboratory abnormalities. Read More

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http://dx.doi.org/10.1155/2019/4890287DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6378786PMC
February 2019
20 Reads

Patiromer Acetate Induced Hypercalcemia: An Unreported Adverse Effect.

Case Rep Nephrol 2019 4;2019:3507407. Epub 2019 Feb 4.

Northeast Ohio Medical University, Department of Medicine, Rootstown, Ohio, USA.

Hyperkalemia, a potential life threating condition, is a commonly encountered problem in chronic kidney disease (CKD) patients. Patiromer acetate, a nonabsorbable cation exchange polymer, is a gastrointestinal agent for chronic therapy in patients with persistent hyperkalemia. Patiromer is generally well tolerated in patients; common side effects are gastrointestinal, such as diarrhea, constipation, flatulence, and vomiting. Read More

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http://dx.doi.org/10.1155/2019/3507407DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6378798PMC
February 2019
3 Reads

Acute Interstitial Nephritis in a Patient with Non-Small Cell Lung Cancer under Immunotherapy with Nivolumab.

Case Rep Nephrol 2019 15;2019:3614980. Epub 2019 Jan 15.

Section of Nephrology and Hypertension, 1st Department of Medicine, AHEPA Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece.

Immune-checkpoint-inhibitors (ICPIs) represent a novel class of immunotherapy against several malignancies. These agents are associated with several "immune-mediated" adverse effects, but the reported renal toxicity of ICPIs is less well defined. We present the case of a 60-year-old man with a history of non-small cell lung cancer, who developed acute kidney injury (AKI) approximately 3. Read More

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http://dx.doi.org/10.1155/2019/3614980DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350541PMC
January 2019
8 Reads