94 results match your criteria Case reports in immunology[Journal]


Injection Site Erythema in a Patient on Therapeutic Anticoagulation with Low Molecular Weight Heparin after Mechanical Aortic Valve Replacement: A Rare Presentation of Heparin- and Protamine-Induced Thrombocytopenia.

Case Reports Immunol 2020 10;2020:4503598. Epub 2020 Apr 10.

Division of Cardiothoracic and Vascular Anesthesia and Intensive Care, Medical University of Vienna, Vienna, Austria.

Previous exposition to heparin and protamine in patients undergoing cardiopulmonary bypass and postoperative therapeutic anticoagulation with LMWH may lead to the development of heparin-induced thrombocytopenia (HIT) and/or protamine-induced thrombocytopenia (PIT). This case deals with a rare clinical presentation of circulating IgG antibodies against heparin/platelet factor 4 complexes and heparin/protamine complexes after cardiac surgery. Ensuing purpura and skin necrosis (blisters) at the injection sites of LMWH and clinical symptoms improved rapidly after replacement of LMWH by an alternative anticoagulant. Read More

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http://dx.doi.org/10.1155/2020/4503598DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7171645PMC

Posttransplantation Lymphoproliferative Disease Treated by Retransplantation.

Case Reports Immunol 2020 25;2020:9403123. Epub 2020 Feb 25.

Department of Hematology, Oslo University Hospital, Rikshospitalet, Oslo, Norway.

Epstein-Barr virus- (EBV-) induced posttransplantation lymphoproliferative disease (PTLD) is a life-threatening complication following allogeneic stem cell transplantation. The main risk factor is anti-thymocyte globulin (ATG). Patients who fail first-line treatment with rituximab have a poor prognosis. Read More

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http://dx.doi.org/10.1155/2020/9403123DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7060862PMC
February 2020

A First Case Report of DiGeorge Syndrome from Ethiopia Highlights Challenges in Identifying and Treating Children with Primary T-Cell Deficiencies in Low Resource Settings.

Case Reports Immunol 2020 26;2020:8157212. Epub 2020 Feb 26.

Department of Pediatrics and Child Health, St. Paul's Hospital and Millennium Medical College, Addis Ababa, Ethiopia.

Background: Cellular primary immunodeficiencies are rarely reported from Africa. DiGeorge syndrome is a commonly recognized form of a congenital T-cell deficiency. The disorder is characterized by hypoplastic or aplastic thymus, hypocalcemia, recurrent infections, and other associated congenital defects. Read More

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http://dx.doi.org/10.1155/2020/8157212DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7061102PMC
February 2020

Cerebellar Ataxia Followed by Stiff Person Syndrome in a Patient with Anti-GAD Antibodies.

Case Reports Immunol 2020 8;2020:8454532. Epub 2020 Feb 8.

Department of Neurology, Royal Melbourne Hospital, Parkville, Melbourne, Victoria, Australia.

Anti-GAD antibody syndrome is a result of the production of antibodies against glutamic acid decarboxylase (GAD), the main enzyme responsible for the production of gamma-aminobutyric acid (GABA). Several neurological manifestations including cerebellar ataxia and stiff person syndrome have been reported in association with anti-GAD antibodies. In this paper, we present a case of a young woman with anti-GAD antibodies who initially presented with cerebellar ataxia followed by stiff person syndrome three and a half years later. Read More

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http://dx.doi.org/10.1155/2020/8454532DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7031724PMC
February 2020

Sirolimus for the Treatment of Airway Obstruction due to Indolent T-Lymphoblastic Proliferation.

Case Reports Immunol 2019 9;2019:1724083. Epub 2019 Dec 9.

Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Introduction: Indolent T-lymphoblastic proliferation (iT-LBP) is a rare nonmalignant entity that presents as a proliferation of T-lymphoblasts. We report a first such case with a recurrent laryngeal obstruction presentation that was successfully controlled with Sirolimus.

Case Presentation: This is the case of a 29-year-old female who presented with a recurrent significant lymphoid hyperplasia in the adenoid and tongue base region as well as a right cervical lymph node. Read More

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http://dx.doi.org/10.1155/2019/1724083DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6959153PMC
December 2019

Primary Immunodeficiency with Severe Multi-Organ Immune Dysregulation.

Case Reports Immunol 2019 28;2019:8746249. Epub 2019 Dec 28.

Assistant Professor, Albert Einstein College of Medicine, Attending in Medicine and Pediatrics, Division of Allergy and Immunology, Montefiore Medical Center, Bronx, NY, USA.

Polyglandular autoimmune syndrome type 1, also known as autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED), is a rare primary immunodeficiency disorder with multi-organ involvement. Besides for being predisposed to severe life-threatening infections, patients with APECED are also prone to organ impairment secondary to severe autoimmunity. As this is an autosomal recessive disorder, a biallelic mutation in the gene is responsible for APECED. Read More

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http://dx.doi.org/10.1155/2019/8746249DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6949663PMC
December 2019

Fatal Hypogammaglobulinemia 3 Years after Rituximab in a Patient with Immune Thrombocytopenia: An Underlying Genetic Predisposition?

Case Reports Immunol 2019 28;2019:2543038. Epub 2019 Dec 28.

INSERM UMR 1163, Laboratory of Immunogenetics of Pediatric Autoimmune Diseases, Paris Descartes-Sorbonne, Paris Cité University, Imagine Institute, Paris, France.

We report the case of a young woman who developed, 3 years after stopping Rituximab (RTX) prescribed for immune thrombocytopenia (ITP), a severe immunodeficiency leading to fatal pulmonary Epstein-Barr virus-positive diffuse large B-cell lymphoma. Genetic analysis led us to identify four missense mutations known to affect immune-deficiency-associated genes (FAS-ligand () gene (p.G167R); perforin-1 ( (p. Read More

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http://dx.doi.org/10.1155/2019/2543038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6949674PMC
December 2019

Evidence that a STAT3 Mutation Causing Hyper IgE Syndrome Leads to Repression of Transcriptional Activity.

Case Reports Immunol 2019 13;2019:1869524. Epub 2019 Oct 13.

Department of Immunology, Royal London Hospital, Barts Health NHS Trust, London, UK.

We present the case of a 19-year-old female with a mild form of Autosomal Dominant Hyper IgE syndrome (HIES) associated with a loss-of-function mutation in . Within the first years of life she developed multiple, associated abscesses in the neck and face requiring frequent incision and drainage. Respiratory tract infections were not a feature of the clinical phenotype and a high resolution thoracic CT scan was unremarkable. Read More

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http://dx.doi.org/10.1155/2019/1869524DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6815622PMC
October 2019

Deficiency of Interleukin-1 Receptor Antagonist: A Case with Late Onset Severe Inflammatory Arthritis, Nail Psoriasis with Onychomycosis and Well Responsive to Adalimumab Therapy.

Case Reports Immunol 2019 4;2019:1902817. Epub 2019 Aug 4.

Ege University Faculty of Medicine, Department of Pediatric Immunology and Rheumatology, Izmir, Turkey.

DIRA (deficiency of the IL-1Ra) is a rare condition that usually presents in the neonatal period. Patients with DIRA present with systemic inflammation, respiratory distress, joint swelling, pustular rash, multifocal osteomyelitis, and periostitis. Previously, we reported a patient with a novel mutation in with a healthy neonatal period, a late-onset of pustular dermatosis, inflammatory arthritis, and excellent response to canakinumab treatment. Read More

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http://dx.doi.org/10.1155/2019/1902817DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6699325PMC
August 2019
6 Reads

Partial and Transient Clinical Response to Omalizumab in IL-21-Induced Low STAT3-Phosphorylation on Hyper-IgE Syndrome.

Case Reports Immunol 2019 4;2019:6357256. Epub 2019 Jul 4.

Immunology and Allergy Department, Centro Médico Nacional 20 de Noviembre, Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado, Mexico.

Hyper-IgE syndrome (HIES) is a rare primary immunodeficiency characterized by elevated levels of immunoglobulin E (IgE), eczematous dermatitis, cold abscesses, and recurrent infections of the lung and skin caused by . The dominant form is characterized by nonimmunologic features including skeletal, connective tissue, and pulmonary abnormalities in addition to recurrent infections and eczema. Omalizumab is a humanized recombinant monoclonal antibody against IgE. Read More

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http://dx.doi.org/10.1155/2019/6357256DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6637684PMC
July 2019
3 Reads

IgG4-Related Sclerosing Disease Causing Spinal Cord Compression: The First Reported Case in Literature.

Case Reports Immunol 2019 18;2019:3618510. Epub 2019 Jun 18.

Department of Hematology and Oncology Medicine, Veterans Affairs Medical Center, Amarillo, TX, USA.

Immunoglobulin G4-related disease (IgG4-RD) is known for forming soft tissue mass lesions that may have compressive effects. It is an extremely rare disease that most frequently affects the pancreas causing autoimmune pancreatitis. It can also affect the gallbladder, salivary glands, and lacrimal glands causing respective organ-specific complications. Read More

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http://dx.doi.org/10.1155/2019/3618510DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6604497PMC

Severe Myositis, Myocarditis, and Myasthenia Gravis with Elevated Anti-Striated Muscle Antibody following Single Dose of Ipilimumab-Nivolumab Therapy in a Patient with Metastatic Melanoma.

Case Reports Immunol 2019 30;2019:2539493. Epub 2019 Apr 30.

University of Arizona College of Medicine - Tucson, 1501 N Campbell Ave, Tucson, AZ 85724, USA.

Immune checkpoint inhibitors targeting programmed cell death protein 1 and cytotoxic T-lymphocyte associated protein 4 have improved survival in patients with metastatic melanoma, especially in combination (i.e., ipilimumab-nivolumab). Read More

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http://dx.doi.org/10.1155/2019/2539493DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6515062PMC
April 2019
5 Reads

Parry-Romberg Syndrome with Uhthoff's Phenomena: A Spectrum of Autoimmune Disease?

Authors:
Samuel Asanad

Case Reports Immunol 2019 18;2019:1752456. Epub 2019 Apr 18.

David Geffen School of Medicine, University of California, Los Angeles, USA.

Parry-Romberg syndrome (PRS) is a rare disorder characterized by unilateral facial atrophy. Currently, the pathogenesis of PRS is poorly understood and no definitive treatment is available. This article reports the case of a 51-year-old woman with progressive hemifacial atrophy following herpes zoster infection, who presented with a concomitant chronic history of heat-induced diplopia. Read More

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http://dx.doi.org/10.1155/2019/1752456DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6500608PMC
April 2019
6 Reads

Vancomycin-Induced Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) Syndrome Masquerading as Elusive Sepsis.

Case Reports Immunol 2019 10;2019:1625010. Epub 2019 Apr 10.

Department of Medicine, Rochester General Hospital, Rochester Regional Health System, Rochester, NY 14621, USA.

We present a unique case of vancomycin-induced drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome masquerading as elusive endocarditis. A 37-year-old female actively using intravenous drugs presented with worsening right upper extremity pain, fever, and chills. Workup revealed methicillin-resistant staphylococcus aureus (MRSA) bacteremia and multiple right-sided septic pulmonary emboli. Read More

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http://dx.doi.org/10.1155/2019/1625010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6481134PMC
April 2019
26 Reads

Anti-N-Methyl-D-Aspartate Encephalitis as Paraneoplastic Manifestation of Germ-Cells Tumours: A Cases Report and Literature Review.

Case Reports Immunol 2019 10;2019:4762937. Epub 2019 Mar 10.

Department of Immunology. Hospital Universitario Ramón y Cajal, Ctra. Colmenar Km 9,1, 28034 Madrid, Spain.

Anti-N-methyl-D-aspartate (NMDA) receptor encephalitis is the most common form of autoimmune encephalitis, caused by the interaction between an antibody and its target, located on glutamate receptor type N-methyl-D-aspartate (NMDA) of neuronal surface. There is a wide spectrum of clinical features starting by a viral-like prodrome, followed by symptoms such as psychosis, aggressive behaviour, memory loss, seizures, movement disorders, and autonomic instability. Up to 50% of the affected young female patients have germ-cells tumours as ovarian teratoma, making it essential to establish an early diagnosis through detection of specific antibodies in serum and cerebrospinal fluid (CSF). Read More

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http://dx.doi.org/10.1155/2019/4762937DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431454PMC
March 2019
3 Reads

Castleman Disease in a Patient with Common Variable Immunodeficiency.

Case Reports Immunol 2019 14;2019:5476383. Epub 2019 Feb 14.

Peritoneal Surface Malignancy and Soft Tissue Sarcoma Program, Messina University Medical School Hospital, Messina, Italy.

Common variable immunodeficiency (CVID) is a primary immunodeficiency due to a disorder of the adaptive immune system which causes hypogammaglobulinemia and therefore an increased susceptibility to infection; noninfectious, inflammatory conditions including systemic autoimmunity and lymphoproliferative complications are also commonly associated with CVID. Castleman disease (CD) is a systemic disease clinically characterized by diffuse lymphadenopathy, splenomegaly, anemia, and systemic inflammatory symptoms. This makes CD a great mimicker of more common benign and malignant masses in the neck, chest, abdomen, and pelvis. Read More

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http://dx.doi.org/10.1155/2019/5476383DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6393918PMC
February 2019
5 Reads

A Forgotten Cause of Allergy at ER That Is Still Difficult to Diagnose and Treat at Poor Resource Setting: Angioedema after Using Angiotensin Converting Enzyme Inhibitors for 4 Years.

Case Reports Immunol 2019 2;2019:1676391. Epub 2019 Jan 2.

North Colombo Teaching Hospital, Ragama, Sri Lanka.

Angiotensin converting enzyme inhibitors (ACEi) are the most commonly used antihypertensives. Therefore, ACEI induced angioedema (ACEi-AE) is not uncommon. Physicians tend to miss the diagnosis whenever a patient is taking the drug for years due to misbelief of "a drug that was taken for years may not be the cause for an allergic reaction or an angioedema". Read More

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http://dx.doi.org/10.1155/2019/1676391DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339731PMC
January 2019
2 Reads

A Case of Eosinophilic Granulomatosis with Polyangiitis Complicated with A IgG4 Related Disease Like Symptoms.

Case Reports Immunol 2018 4;2018:3763084. Epub 2018 Nov 4.

Department of Pulmonary Medicine, School of Medicine, Fukushima Medical University, Fukushima, Japan.

We report a case of eosinophilic granulomatosis with polyangiitis (EGPA) complicated with a IgG4 related disease like symptoms presenting as eyelid swellings. In the present case, the serum level of IgG4 and the ratio of IgG4 to IgG were generally increased by the disease course of EGPA. Considering the course of clinical symptoms, there is a possibility that orbital manifestations were one of the clinical features during the disease course of EGPA while the histological features of right eyelid tissue and other ocular manifestations were consistent with the diagnosis of IgG4 related disease. Read More

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http://dx.doi.org/10.1155/2018/3763084DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332970PMC
November 2018
7 Reads

Hereditary Angioedema Type II: First Presentation in Adulthood with Recurrent Severe Abdominal Pain.

Case Reports Immunol 2018 29;2018:7435870. Epub 2018 Oct 29.

Cleveland Clinic Abu Dhabi, UAE.

A 27-year-old Emirate man presented to Cleveland Clinic Abu Dhabi emergency department with a 4 year history of recurrent episodes of severe swellings affecting different parts of his body. He used to get 2 swelling episodes every week affecting either his face, hands, feet or scrotum and severe abdominal pain twice a week. Abdominal CT scan and a colonoscopy showed bowel wall oedema. Read More

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http://dx.doi.org/10.1155/2018/7435870DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6231379PMC
October 2018
4 Reads

An X-Linked Hyper-IgM Patient Followed Successfully for 23 Years without Hematopoietic Stem Cell Transplantation.

Case Reports Immunol 2018 14;2018:6897935. Epub 2018 Oct 14.

Ege University Faculty of Medicine, Department of Medical Genetics, Izmir, Turkey.

When caring for patients with life-limiting diseases, improving survival and optimizing quality of life are the primary goals. For patients with X-linked hyper-IgM syndrome (XHIGM), the treatment modality has to be decided for a particular patient regarding hematopoietic stem cell transplantation or intravenous immunoglobulin replacement therapy with prophylaxis. A seven-year-old male patient was admitted with recurrent upper and lower respiratory tract infections and recurrent otitis media. Read More

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https://www.hindawi.com/journals/crii/2018/6897935/
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http://dx.doi.org/10.1155/2018/6897935DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6204170PMC
October 2018
10 Reads

Successful Treatment of Severe Type B Lactic Acidosis in a Patient with HIV/AIDS-Associated High-Grade NHL.

Case Reports Immunol 2018 13;2018:9093623. Epub 2018 Sep 13.

Division of Academic Affairs and Research, Orlando Regional Healthcare, Orlando, FL, USA.

Type B lactic acidosis is a rare metabolic complication sometimes associated with hematologic malignancies. When present, this type of lactic acidosis is most commonly seen in patients with high-grade lymphomas or leukemias and is usually indicative of a dismal prognosis. We report a case of a 27-year man with acquired immunodeficiency syndrome (AIDS) that presented with bilateral lower extremity swelling, an abdominal mass, and weight loss. Read More

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https://www.hindawi.com/journals/crii/2018/9093623/
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http://dx.doi.org/10.1155/2018/9093623DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6158940PMC
September 2018
4 Reads

A Novel STAT3 Gene Mutation Related Hyper-IgE Syndrome Misdiagnosed as Hidradenitis Suppurativa.

Case Reports Immunol 2018 13;2018:4860902. Epub 2018 Aug 13.

Division of Pulmonary, Allergy, and Critical Care Medicine, Penn State College of Medicine, Hershey, PA, USA.

Although Hyper-IgE Syndrome (HIES) is a rare immunodeficiency disorder, presenting symptoms may be as common as lung and skin infections. Symptoms are usually nonspecific such as recurrent abscesses, folliculitis, and pneumonias along with skeletal abnormalities. Careful history of susceptibility to skin and lung infections, thorough family history, and findings on physical exam can guide towards the diagnosis of this often-eluded condition. Read More

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https://www.hindawi.com/journals/crii/2018/4860902/
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http://dx.doi.org/10.1155/2018/4860902DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6110011PMC
August 2018
10 Reads

Severe Allergic Bronchopulmonary Mycosis and Long-Term Follow-Up.

Case Reports Immunol 2018 12;2018:4251673. Epub 2018 Aug 12.

Department of Internal Medicine, Division of Rheumatology, Shiraz University of Medical Sciences, Shiraz, Iran.

Allergic bronchopulmonary aspergillosis (ABPA) is the most common immunologic reaction following fungal allergen exposure in asthmatic patients. A less frequent syndrome in response to other fungal species like candida is allergic bronchopulmonary mycosis (ABPM). This reaction is mostly associated with asthma exacerbation, changes in Immunoglobulin E levels, and nonspecific findings in high resolution computed tomography (HRCT). Read More

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http://dx.doi.org/10.1155/2018/4251673DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6109528PMC
August 2018
4 Reads

Omalizumab for Idiopathic Nonhistaminergic Angioedema: Evidence for Efficacy in 2 Patients.

Case Reports Immunol 2018 22;2018:8067610. Epub 2018 Jul 22.

Department of Biomedical Sciences, Humanitas University, Milan, Italy.

Presently, there is inconclusive evidence regarding the most effective treatment for idiopathic nonhistaminergic acquired angioedema (InH-AAE). Omalizumab may, however, prove to be a promising option. This case report describes two patients who presented with recurrent angioedema attacks, which was refractory to antihistamine therapy. Read More

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http://dx.doi.org/10.1155/2018/8067610DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6081528PMC
July 2018
20 Reads

Efficacy of Nivolumab in a Patient with Metastatic Renal Cell Carcinoma and End-Stage Renal Disease on Dialysis: Case Report and Literature Review.

Case Reports Immunol 2018 13;2018:1623957. Epub 2018 Jun 13.

Department of Oncology, Prince Sultan Military Medical City, Riyadh, Saudi Arabia.

Treatment of patients with metastatic renal cell carcinoma (mRCC) and end-stage renal disease (ESRD) on dialysis poses a therapeutic challenge, particularly as this patient group was excluded from the pivotal clinical trials. In addition, there is uncertainty regarding drug dosing/pharmacokinetics, lack of safety and efficacy data, and potential for increased toxicity when using targeted therapy or immunotherapy for the management of patients with mRCC on dialysis. Nivolumab, an anti-programmed death-1 immune checkpoint inhibitor antibody, is indicated for the treatment of patients with mRCC who have received prior antiangiogenic therapy. Read More

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https://www.hindawi.com/journals/crii/2018/1623957/
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http://dx.doi.org/10.1155/2018/1623957DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6020478PMC
June 2018
32 Reads

EBV Infection in XLP1 Manifested Solely by Behavioral Aggression and Effective Treatment Using Rituximab.

Case Reports Immunol 2018 7;2018:3705376. Epub 2018 Jun 7.

Section of Allergy/Immunology, Department of Pediatrics, Louisiana State University School of Medicine, New Orleans, Children's Hospital of New Orleans, 200 Henry Clay Avenue, New Orleans, LA 70118, USA.

Patients with X-linked lymphoproliferative disease 1 (XLP1) are exquisitely susceptible to Epstein-Barr virus (EBV), with the first EBV infection often resulting in rapid death. In a manner not previously described, a 5-year-old patient with XLP1 presented solely with behavioral aggression, with no laboratory evidence of organ dysfunction or inflammation. Although EBV-IgM was negative, PCR confirmed the presence of EBV in both the blood and cerebrospinal fluid. Read More

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http://dx.doi.org/10.1155/2018/3705376DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6011099PMC
June 2018
40 Reads

Runaway Train: A Leaky Radiosensitive SCID with Skin Lesions and Multiple Lymphomas.

Case Reports Immunol 2018 14;2018:2053716. Epub 2018 May 14.

Department of Hematology, Oslo University Hospital, Oslo, Norway.

The nuclease Artemis is essential for the development of T-cell and B-cell receptors and repair of DNA double-strand breaks, and a loss of expression or function will lead to a radiosensitive severe combined immunodeficiency with no functional T-cells or B-cells (T-B-SCID). Hypomorphic mutations in the gene can lead to a functional, but reduced, T-cell and B-cell repertoire with a more indolent clinical course called "leaky" SCID. Here, we present the case of a young man who had increasingly aggressive lymphoproliferative skin lesions from 2 years of age which developed into multiple EBV+ B-cell lymphomas, where a hypomorphic mutation in the gene was found in a diagnostic race against time using whole exome sequencing. Read More

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http://dx.doi.org/10.1155/2018/2053716DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5977007PMC
May 2018
4 Reads

Effective Immunotherapy in Bone Marrow Metastatic Melanoma Presenting with Disseminated Intravascular Coagulopathy.

Case Reports Immunol 2018 12;2018:4520294. Epub 2018 Feb 12.

Beaumont Hospital, Oakland University School of Medicine, Department of Hematology and Oncology, Royal Oak, MI, USA.

Malignant melanoma is responsible for the majority of skin cancer deaths and is increasing in prevalence. Bone marrow (BM) involvement by melanoma is rare in the absence of widespread visceral disease. Here, we report the case of a 30-year-old female who presented to the hospital with back pain, low-grade fever, and easy bruising. Read More

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http://dx.doi.org/10.1155/2018/4520294DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5896417PMC
February 2018
20 Reads

Elevated Serum IgG4 Levels in a Young Patient with Polyserositis and Infection.

Case Reports Immunol 2018 31;2018:2974756. Epub 2018 Jan 31.

Istituto di Malattie Infettive AOU Sassari, Viale San Pietro, 07100 Sassari, Italy.

IgG4-related disease is a fibroinflammatory systemic condition characterized by tumefactive lesions, lymphoplasmacytic infiltrate rich in IgG4-positive plasma cells, storiform fibrosis, and elevated serum IgG4 concentrations. It has been described in virtually every organ system. Autoimmunity and infectious agents are potential immunologic triggers in IgG4-related disease. Read More

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http://dx.doi.org/10.1155/2018/2974756DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5831313PMC
January 2018
5 Reads

In Vitro Fertilization Using Luteinizing Hormone-Releasing Hormone Injections Resulted in Healthy Triplets without Increased Attack Rates in a Hereditary Angioedema Case.

Case Reports Immunol 2018 13;2018:2706751. Epub 2018 Feb 13.

Department of Internal Medicine, Division of Allergy and Clinical Immunology, Ege University Medical Faculty, İzmir, Turkey.

Hereditary angioedema due to C1-inhibitor deficiency (C1-INH-HAE) is a rare, autosomal dominant disorder. The management of pregnant patients with C1-INH-HAE is a challenge for the physician. Intravenous plasma-derived nanofiltered C1-INH (pdC1INH) is the only recommended option throughout pregnancy, postpartum, and breastfeeding period. Read More

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http://dx.doi.org/10.1155/2018/2706751DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5831601PMC
February 2018
8 Reads

Gain-of-Function Mutations in : A Recently Defined Cause for Chronic Mucocutaneous Candidiasis Disease Mimicking Combined Immunodeficiencies.

Case Reports Immunol 2017 13;2017:2846928. Epub 2017 Nov 13.

Ege University Medical Faculty, Department of Pediatric Immunology, Izmir, Turkey.

Chronic Mucocutaneous Candidiasis (CMC) is the chronic, recurrent, noninvasive Candida infections of the skin, mucous membranes, and nails. A 26-month-old girl was admitted with the complaints of recurrent oral Candidiasis, diarrhea, and respiratory infections. grew in oral mucosa swab. Read More

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http://dx.doi.org/10.1155/2017/2846928DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5702932PMC
November 2017
51 Reads

Concomitant Transverse Myelitis and Acute Axonal Sensory-Motor Neuropathy in an Elderly Patient.

Case Reports Immunol 2017 13;2017:7289474. Epub 2017 Jul 13.

Department of Neurology, University of Sao Paulo, Sao Paulo, SP, Brazil.

Diagnosing concomitant transverse myelitis (TM) and Guillain-Barré syndrome (GBS) can be challenging. We report a case of an elderly patient presenting with acute sensory and motor disturbances in the four limbs, associated with urinary retention, ophthalmoparesis, facial weakness, and dysarthria. Electrodiagnostic studies were consistent with acute motor sensory axonal neuropathy (AMSAN), and imaging showed a longitudinally extensive tumefactive contrast-enhancing hyperintense spinal cord lesion extending from T6 to the cone. Read More

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http://dx.doi.org/10.1155/2017/7289474DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5530449PMC

Corrigendum to "Docetaxel-Induced Systemic Sclerosis with Internal Organ Involvement Masquerading as Congestive Heart Failure".

Case Reports Immunol 2017 29;2017:4809124. Epub 2017 Jun 29.

Department of Family Medicine, Henry Ford Hospital, Wayne State University School of Medicine, Detroit, MI 48202, USA.

[This corrects the article DOI: 10.1155/2017/4249157.]. Read More

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http://dx.doi.org/10.1155/2017/4809124DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5494544PMC
June 2017
5 Reads

Beer, Cider, and Wine Allergy.

Case Reports Immunol 2017 15;2017:7958924. Epub 2017 Mar 15.

St Helier Hospital, Wrythe Lane, Carshalton, Surrey SM5 1AA, UK.

. Allergy to beer is often due to specific proteins in barley and sometimes to lipid transfer protein. Allergy to wine is frequently due to a sensitivity to grape proteins. Read More

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http://dx.doi.org/10.1155/2017/7958924DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5371212PMC
March 2017
44 Reads

Docetaxel-Induced Systemic Sclerosis with Internal Organ Involvement Masquerading as Congestive Heart Failure.

Case Reports Immunol 2017 6;2017:4249157. Epub 2017 Feb 6.

Department of Family Medicine, Henry Ford Hospital, Wayne State University School of Medicine, Detroit, MI 48202, USA.

Systemic sclerosis, or scleroderma, is a complex medical disorder characterized by limited or diffuse skin thickening with frequent involvement of internal organs such as lungs, gastrointestinal tract, or kidneys. Docetaxel is a chemotherapeutic agent which has been associated with cutaneous side effects. An uncommon cutaneous side effect of docetaxel is scleroderma-like skin changes that extend from limited to diffuse cutaneous systemic sclerosis. Read More

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http://dx.doi.org/10.1155/2017/4249157DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5317138PMC
February 2017
10 Reads

Necrotizing Liver Granuloma/Abscess and Constrictive Aspergillosis Pericarditis with Central Nervous System Involvement: Different Remarkable Phenotypes in Different Chronic Granulomatous Disease Genotypes.

Case Reports Immunol 2017 10;2017:2676403. Epub 2017 Jan 10.

Pediatric Immunology Department, Medical Faculty, Ege University, Izmir, Turkey.

Chronic granulomatous disease (CGD) is a primary immune deficiency causing predisposition to infections with specific microorganisms, species and being the most common ones. A 16-year-old boy with a mutation in CYBB gene coding gp91 protein (X-linked disease) developed a liver abscess due to . In addition to medical therapy, surgical treatment was necessary for the management of the disease. Read More

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https://www.hindawi.com/journals/crii/2017/2676403/
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http://dx.doi.org/10.1155/2017/2676403DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5259602PMC
January 2017
17 Reads

Pure Cold-Induced Cholinergic Urticaria in a Pediatric Patient.

Case Reports Immunol 2016 29;2016:7425601. Epub 2016 Nov 29.

Allergy/Immunology Associates, Inc., Mayfield Heights, OH, USA.

Cold urticaria and cholinergic urticaria are two distinct entities. The presentation of exclusive cold-induced cholinergic urticaria is very rare. The patient described herein had experienced urticaria in the exclusive setting of exercising in a cold environment. Read More

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http://dx.doi.org/10.1155/2016/7425601DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5153475PMC
November 2016
34 Reads

Successful Pregnancy Outcome in Women with Recurrent IVF Failure and Anti-hCG Autoimmunity: A Report of Three Cases.

Case Reports Immunol 2016 24;2016:4391537. Epub 2016 Nov 24.

Department of Assisted Reproduction Technologies, FSBI D. O. Ott Research Institute of Obstetrics, Gynecology and Reproductology, Saint Petersburg, Russia.

We report three cases of effective management of infertility in women with a history of repeated unsuccessful IVF attempts, who have developed antibodies to hCG. A novel approach to conservative treatment of immunologic reproductive failure, suggested for selected patients, included membrane plasmapheresis, combined prednisolone, and intravenous immunoglobulin therapy. No adverse side effects were observed; all cases resulted in pregnancy and subsequent life births. Read More

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http://dx.doi.org/10.1155/2016/4391537DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5143722PMC
November 2016
5 Reads

Differential Impairment of Interferon- Responses in Two Cases of Pulmonary Nontuberculous Mycobacterial Disease.

Case Reports Immunol 2016 16;2016:9165641. Epub 2016 Nov 16.

University Hospital Southampton NHS Foundation Trust, Southampton, UK; Academic Unit of Cancer Sciences, Faculty of Medicine, University of Southampton and Southampton NIHR Experimental Cancer Medicine Centre, Southampton, UK.

Nontuberculous mycobacteria (NTMs) are weakly virulent intracellular pathogens that are common in food and water supplies. The persistent culture of these organisms in the setting of clinical infection warrants investigation of immune function. In cases of isolated pulmonary NTM (PNTM) disease, underlying immune defects have not been clearly identified. Read More

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http://dx.doi.org/10.1155/2016/9165641DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5128696PMC
November 2016
14 Reads

Tranexamic Acid: An Exceedingly Rare Cause of Anaphylaxis during Anaesthesia.

Case Reports Immunol 2016 31;2016:7828351. Epub 2016 Oct 31.

Department of Immunology and Allergy, St Helier Hospital, Carshalton, Surrey SM5 1AA, UK.

Tranexamic acid (TXA) allergy is extremely rare. An 80-year-old woman without prior exposure to TXA underwent elective knee replacement. Shortly after induction of anaesthesia and intravenous TXA, she developed hypotension, tachycardia, and facial erythema accompanied by a raised serum tryptase. Read More

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http://dx.doi.org/10.1155/2016/7828351DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5107845PMC
October 2016
1 Read

Giant Condyloma Acuminata in Indonesian Females with SLE under Immunosuppressant and Steroid Therapy.

Case Reports Immunol 2016 24;2016:4710979. Epub 2016 Oct 24.

Faculty of Medicine, University of Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia.

Immunosuppressant and steroid therapy in systemic lupus erythematosus (SLE) increases the risk of human papillomavirus (HPV) infections, one of which is giant condyloma acuminata (GCA). To our knowledge, there is no report evaluating the correlation between immunosuppressive and steroid therapy in patients with SLE and the prevalence of GCA. A 42-year-old female was diagnosed with SLE a year ago and has been treated with steroids and immunosuppressive drugs. Read More

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http://dx.doi.org/10.1155/2016/4710979DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5098063PMC
October 2016
10 Reads

Successful Use of Tocilizumab in a Patient with Coexisting Rheumatoid Arthritis and Ulcerative Colitis.

Case Reports Immunol 2016 12;2016:7562123. Epub 2016 Oct 12.

Queen Elizabeth the Queen Mother Hospital, Margate, UK.

Tocilizumab is an interleukin-6 receptor inhibitor licensed for moderate to severe rheumatoid arthritis (RA). We report a case of Tocilizumab monotherapy for severe active RA in a patient with coexisting ulcerative colitis (UC). The patient was intolerant to multiple disease-modifying drugs, so Tocilizumab monotherapy was commenced. Read More

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http://dx.doi.org/10.1155/2016/7562123DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5080477PMC
October 2016
2 Reads

Early Diagnosis and Hematopoietic Stem Cell Transplantation for IL10R Deficiency Leading to Very Early-Onset Inflammatory Bowel Disease Are Essential in Familial Cases.

Case Reports Immunol 2016 6;2016:5459029. Epub 2016 Sep 6.

Faculty of Medicine, Department of Pediatric Immunology, Ege University, Izmir, Turkey.

Alterations of immune homeostasis in the gut may result in development of inflammatory bowel disease. A five-month-old girl was referred for recurrent respiratory and genitourinary tract infections, sepsis in neonatal period, chronic diarrhea, perianal abscess, rectovaginal fistula, and hyperemic skin lesions. She was born to second-degree consanguineous, healthy parents. Read More

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http://dx.doi.org/10.1155/2016/5459029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5028855PMC
September 2016
54 Reads

Autoimmune Lymphoproliferative Syndrome: A Rare Cause of Disappearing HDL Syndrome.

Case Reports Immunol 2016 8;2016:7945953. Epub 2016 Aug 8.

Division of Pediatric Endocrinology, Mayo Clinic, Rochester, MN 55902, USA.

The term disappearing HDL syndrome refers to development of severe high density lipoprotein cholesterol (HDL-C) deficiency in noncritically ill patients with previously normal HDL-C and triglyceride levels. Autoimmune lymphoproliferative syndrome (ALPS) is a disorder of the immune system due to an inability to regulate lymphocyte homeostasis resulting in lymphadenopathy and hepatosplenomegaly. We describe a 17-year-old boy who was evaluated in the lipid clinic for history of undetectable or low HDL-C and low density lipoprotein cholesterol (LDL-C) levels. Read More

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http://dx.doi.org/10.1155/2016/7945953DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4992760PMC

Abnormal TREC-Based Newborn Screening Test in a Premature Neonate with Massive Perivillous Fibrin Deposition of the Placenta.

Case Reports Immunol 2016 22;2016:5083274. Epub 2016 Jun 22.

The Alpert Medical School of Brown University, 222 Richmond Street, Providence, RI 02903, USA; Division of Pediatric Allergy and Immunology, Hasbro Children's Hospital/Rhode Island Hospital, 593 Eddy Street, Providence, RI 02903, USA.

Severe combined immunodeficiency (SCID), a primary immunodeficiency arising from variable defects in lymphocyte development and survival, is characterized by significant deficiency of thymus derived (T-) lymphocytes and variable defects in the B-lymphocyte population. Newborn screening for SCID is based on detection of low numbers of T-cell receptor excision circles (TRECs) by real time quantitative PCR (RT-qPCR). This screening allows for early identification of individuals with SCID and other disorders characterized by T-lymphopenia. Read More

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http://dx.doi.org/10.1155/2016/5083274DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4923521PMC
July 2016
17 Reads

Mycetoma Caused by Acremonium Species in a Patient with Chronic Granulomatous Disease.

Case Reports Immunol 2016 28;2016:3209493. Epub 2016 Feb 28.

Department of Immunology, Heartlands Hospital, Bordesley Green East, Birmingham B9 5SS, UK.

Patients with chronic granulomatous disease are predisposed to fungal infections and are therefore routinely prescribed antifungal prophylaxis. We report a case where acremonium was responsible for causing a cutaneous infection (mycetoma) despite antifungal prophylaxis. Treatment with voriconazole was initiated and the infection gradually resolved. Read More

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http://www.hindawi.com/journals/crii/2016/3209493/
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http://dx.doi.org/10.1155/2016/3209493DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4789031PMC
March 2016
5 Reads

Successful Use of Plasma Exchange in the Treatment of Corticosteroid-Refractory Eosinophilic Granulomatosis with Polyangiitis Associated with Gastrointestinal Manifestations.

Case Reports Immunol 2016 17;2016:8341751. Epub 2016 Feb 17.

Department of Clinical Immunology and Rheumatology, Kitano Hospital, The Tazuke Kofukai Medical Research Institute, Osaka 530-8480, Japan.

We describe the case of a 33-year-old woman having corticosteroid-refractory eosinophilic granulomatosis with polyangiitis (EGPA) who presented with abdominal pain and responded dramatically to plasma exchange. Eosinophilia, asthma history, neuropathy, pulmonary infiltrates, and paranasal sinus abnormalities confirmed the diagnosis of EGPA. Treatment was initiated with 1 g/day of methylprednisolone pulse therapy for 3 days followed by 60 mg/day of intravenous prednisolone without relieving abdominal pain. Read More

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http://www.hindawi.com/journals/crii/2016/8341751/
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http://dx.doi.org/10.1155/2016/8341751DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4773532PMC
March 2016
3 Reads

Refractory Immunological Thrombocytopenia Purpura and Splenectomy in Pregnancy.

Case Reports Immunol 2015 22;2015:216362. Epub 2015 Dec 22.

Center for Autoimmune Diseases Research (CREA), School of Medicine and Health Sciences, Universidad del Rosario, Bogotá, Colombia.

Thrombocytopenia is defined as a platelet count of less than 100,000 platelets per microlitre (mcL). Thrombocytopenia develops in approximately 6-7% of women during pregnancy and at least 3% of these cases are caused by immunological platelet destruction. Herein, we present a pregnant woman who develops at the first trimester autoimmune thrombocytopenia purpura associated with positive antiphospholipid antibodies. Read More

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http://dx.doi.org/10.1155/2015/216362DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4698536PMC
January 2016
4 Reads

Systemic Sarcoidosis Presenting with Headache and Stroke-Like Episodes.

Case Reports Immunol 2015 29;2015:619867. Epub 2015 Sep 29.

Department of Neurology, Royal Victoria Hospital, Belfast BT12 6BA, UK.

Sarcoidosis is a multisystem granulomatous disorder. Neurological manifestations as a presenting symptom are relatively rare. A 26-year-old male presented with a five-week history of headache suggestive of raised intracranial pressure. Read More

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http://dx.doi.org/10.1155/2015/619867DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4603591PMC
October 2015
1 Read

Nocardia Brain Abscess and CD4(+) Lymphocytopenia in a Previously Healthy Individual.

Case Reports Immunol 2015 16;2015:374956. Epub 2015 Sep 16.

University Hospitals Richmond Medical Center, Richmond Heights, OH 27100, USA.

Nocardia brain abscesses are a known occurrence in patients with immunocompromised conditions. Nocardial infection is commonly an unfortunate sequela to other complications which these patients are being followed up and treated for. The incidence of nocardial brain abscess in an otherwise healthy patient is extremely rare. Read More

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http://www.hindawi.com/journals/crii/2015/374956/
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http://dx.doi.org/10.1155/2015/374956DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4581505PMC
October 2015
9 Reads