160 results match your criteria Case reports in hepatology[Journal]


A Case of Drug-Induced Liver Injury Secondary to Natalizumab.

Case Reports Hepatol 2020 16;2020:7976585. Epub 2020 Jun 16.

Department of Internal Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.

A 33-year-old Caucasian female with relapsing-remitting multiple sclerosis presented with abdominal pain, nausea, and vomiting and was found to have acute liver injury. After thorough investigation, she was diagnosed with drug-induced liver injury (DILI) thought secondary to redosing of Natalizumab therapy. Read More

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http://dx.doi.org/10.1155/2020/7976585DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7315275PMC

Zinc Monotherapy as an Alternative Treatment Option for Decompensated Liver Disease due to Wilson Disease?

Case Reports Hepatol 2020 14;2020:1275940. Epub 2020 Jan 14.

Mekelle University, College of Health Science, Clinical Pharmacist, Tigray, Ethiopia.

Background: Wilson disease is a rare metabolic disorder involving copper metabolism, and patients may present with a variable degree of hepatic, neurologic, and psychiatric manifestations. In the case of hepatic presentation, treatment is usually initiated with potentially toxic copper chelators (D-penicillamine or Trenton). Although zinc is of low toxicity and low cost for treatment of Wilson disease, it has been limited to the adjunctive as a single maintenance drug or for asymptomatic patients. Read More

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http://dx.doi.org/10.1155/2020/1275940DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7201455PMC
January 2020

Successful Treatment of Crizotinib-Induced Fulminant Liver Failure: A Case Report and Review of Literature.

Case Reports Hepatol 2020 10;2020:8247960. Epub 2020 Mar 10.

MUH James D. Eason Transplant Institute, University of Tennessee Health Sciences Center, 1265 Union Avenue, 4 Shorb Tower, Memphis, TN 38104, USA.

Crizotinib is a first-line tyrosine kinase inhibitor used for the treatment of metastatic lung cancer. Crizotinib-induced hepatotoxicity is a rare event. We report a case of a 46-year-old female with a history of metastatic lung cancer who presented with acute liver failure after being on crizotinib for two months. Read More

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http://dx.doi.org/10.1155/2020/8247960DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7085870PMC

Hepatic Cyst: An Unusual Suspect of Syncope.

Case Reports Hepatol 2020 28;2020:1659718. Epub 2020 Feb 28.

Department of Gastroenterology, NYCHH-Coney Island Hospital, Brooklyn, NY, USA.

The patient is a 75-year-old man with history of diabetes and hypertension who presented with syncope after experiencing sharp, 10/10 right flank and abdominal pain worsening over three weeks associated with decreased appetite. Physical examination revealed hepatomegaly and right lower quadrant (RUQ) tenderness, negative for peritoneal signs. Bloodwork showed leukocytosis (13 K/mcl), alkaline phosphatase (141 U/L), total bilirubin (2. Read More

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http://dx.doi.org/10.1155/2020/1659718DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7064878PMC
February 2020

Clarithromycin-Associated Acute Liver Failure Leading to Fatal, Massive Upper Gastrointestinal Hemorrhage from Profound Coagulopathy: Case Report and Systematic Literature Review.

Case Reports Hepatol 2020 18;2020:2135239. Epub 2020 Feb 18.

Division of Gastroenterology & Hepatology, Department of Medicine, William Beaumont Hospital, 3535 W Thirteen Mile Rd, Royal Oak, MI 48073, USA.

While erythromycin has caused numerous cases of acute liver failure (ALF), clarithromycin, a similar macrolide antibiotic, has caused only six reported cases of ALF. A new case of clarithromycin-associated ALF is reported with hepatic histopathology and exclusion of other etiologies by extensive workup, and the syndrome of clarithromycin-associated ALF is better characterized by systematic review. A 60-year-old nonalcoholic man, with normal baseline liver function tests, was admitted with diffuse abdominal pain and AST = 499 U/L and ALT = 539 U/L, six days after completing a 7-day course of clarithromycin 500 mg twice daily for suspected upper respiratory infection. Read More

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http://dx.doi.org/10.1155/2020/2135239DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7049424PMC
February 2020

Hepatocellular Glycogen Accumulation in the Setting of Poorly Controlled Type 1 Diabetes Mellitus: Case Report and Review of the Literature.

Case Reports Hepatol 2020 17;2020:9368348. Epub 2020 Feb 17.

Michigan State University, Department of Internal Medicine, East Lansing, MI, USA.

Glycogenic hepatopathy (GH) is the accumulation of glycogen in the hepatocytes and represents a rare complication in patients with diabetes mellitus (DM), most commonly type 1 DM. We present a case of a 23-year-old woman with a medical history of poorly controlled type 1 DM and gastroesophageal reflux disease (GERD) who presented with progressively worsening right-sided abdominal pain. Diagnostic workup resulted in a liver biopsy with hepatocytes that stained heavily for glycogen with no evidence of fibrosis or steatohepatitis. Read More

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http://dx.doi.org/10.1155/2020/9368348DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7048907PMC
February 2020

The Fire from Within: Multiorgan Failure with Bimodal Rhabdomyolysis from Exertional Heat Stroke.

Case Reports Hepatol 2020 7;2020:1305730. Epub 2020 Feb 7.

The Medical City, Ortigas Avenue, Pasig, Philippines.

Heat stroke (HS) is a condition characterized by a rise in core body temperature and central nervous system dysfunction. It is divided into two types: classical and exertional. Exertional heat stroke (EHS) is accompanied by organ failure. Read More

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http://dx.doi.org/10.1155/2020/1305730DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7029301PMC
February 2020

Successful Kidney Transplantation in a Recipient Coinfected with Hepatitis C Genotype 2 and HIV from a Donor Infected with Hepatitis C Genotype 1 in the Direct-Acting Antiviral Era.

Case Reports Hepatol 2020 29;2020:7679147. Epub 2020 Jan 29.

Division of Infectious Diseases, Department of Internal Medicine, Brown Alpert Medical School, Providence, RI, USA.

Despite significant advances in transplantation of HIV-infected individuals, little is known about HIV coinfected patients with hepatitis C virus (HCV) genotypes other than genotype 1, especially when receiving HCV-infected organs with a different genotype. We describe the first case of kidney transplantation in a man coinfected with hepatitis C and HIV in our state. To our knowledge, this is also the first report of an HIV/HCV/HBV tri-infected patient with non-1 (2a) HCV genotype who received an HCV-infected kidney graft with the discordant genotype (1a), to which he converted after transplant. Read More

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http://dx.doi.org/10.1155/2020/7679147DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7011348PMC
January 2020

Benefit of -Acetylcysteine in Postoperative Hepatic Dysfunction: Case Report and Review of Literature.

Case Reports Hepatol 2019 17;2019:4730381. Epub 2019 Dec 17.

Veterans Affairs Maryland Healthcare System, University of Maryland School of Medicine, USA.

-Acetylcysteine (NAC) is reported to have multiple clinical applications in addition to being the specific antidote for acetaminophen toxicity. NAC stimulates glutathione biosynthesis, promotes detoxification, and acts directly as a scavenger of free radicals. It is a powerful antioxidant and a potential treatment option for diseases characterized by the generation of free oxygen radicals. Read More

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http://dx.doi.org/10.1155/2019/4730381DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6942756PMC
December 2019

Hepatic Sarcoidosis Complicated with Pancreatic Adenocarcinoma.

Case Reports Hepatol 2019 19;2019:9383019. Epub 2019 Nov 19.

Department of Gastroenterology, UMMS-Baystate, Springfield, MA, USA.

Sarcoidosis is a systemic noncaseous granulomatous disease. The liver is a common location but usually asymptomatic. Current literature suggests an association between sarcoidosis and cancers. Read More

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http://dx.doi.org/10.1155/2019/9383019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6885758PMC
November 2019

Rapid Development of Bleeding Esophageal Varices after Placement of Continuous Flow Left Ventricular Assist Device.

Case Reports Hepatol 2019 6;2019:8410420. Epub 2019 Nov 6.

Department of Medicine, Division of Gastroenterology, NorthShore University HealthSystem, Evanston, IL, USA.

We describe a patient with compensated cirrhosis and portal hypertension who underwent continuous flow LVAD implantation. Shortly after LVAD implantation, the patient developed new onset bleeding esophageal varices and ultimately had a fatal outcome. Our experience suggests that even well-compensated cirrhotic patients with significant portal hypertension are at risk of variceal bleeding after LVAD placement. Read More

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http://dx.doi.org/10.1155/2019/8410420DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6875215PMC
November 2019

Hepatic Silicone Granulomas Secondary to Ruptured Breast Implants: A Report of Two Cases.

Case Reports Hepatol 2019 3;2019:7348168. Epub 2019 Nov 3.

Division of Gastroenterology and Hepatology, Department of Medicine, Rutgers Robert Wood Johnson Medical School, Clinical Academic Building Suite 5100B, 125 Paterson St, New Brunswick, NJ 08901, USA.

The differential diagnosis of hepatic granulomas is vast and includes infections, drugs, immunologic diseases, foreign material exposure, and neoplasia. Silicone, whether directly injected into tissues or used as a filler in breast implants, is known to cause localized granulomatous reactions. It can also migrate to other anatomic locations resulting in granulomatous inflammation at a distance. Read More

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http://dx.doi.org/10.1155/2019/7348168DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6875346PMC
November 2019

Acute Hepatitis Secondary to the Use of (Mate Tea): A Case Report and Review of Literature.

Case Reports Hepatol 2019 13;2019:8459205. Epub 2019 Oct 13.

Mayo Clinic Arizona, 5777 E Mayo Blvd, Phoenix, AZ 85054, USA.

Drug induced liver injury is a very frequent cause of hepatotoxicity and within that group, herbal and dietary supplements are a well described subcategory. The following clinical vignette describes the case of a young man with acute hepatitis secondary to the use of , also known as yerba mate, which is a herbal product commonly drunk in South America. This is the first written case of mate tea induced hepatotoxicity. Read More

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http://dx.doi.org/10.1155/2019/8459205DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6815554PMC
October 2019

Hepatocellular Adenoma in a Patient with Ornithine Transcarbamylase Deficiency.

Case Reports Hepatol 2019 2;2019:2313791. Epub 2019 Oct 2.

Department of Pathology, University of Washington, Seattle, WA, USA.

Ornithine transcarbamylase (OTC) deficiency is an X-linked recessive disorder that leads to hyperammonemia and liver damage. Hepatocellular adenoma in OTC deficiency patients has not been previously described. Here we report the first such case to be described in the English language scientific literature. Read More

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http://dx.doi.org/10.1155/2019/2313791DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6791257PMC
October 2019

Prolonged Serum Alanine Aminotransferase Elevation Associated with Isotretinoin Administration.

Case Reports Hepatol 2019 17;2019:9270827. Epub 2019 Jul 17.

Marion Bessin Liver Research Center, Division of Hepatology, Albert Einstein College of Medicine and Montefiore Medical Center, 1300 Morris Park Avenue, Bronx, NY 10461, USA.

Isotretinoin is a highly effective oral retinoid derivative for severe forms of acne. Despite its high margin of safety, isotretinoin carries a risk of teratogenicity and mild to massive elevations of serum cholesterol and triglyceride levels, as well as infrequent transaminitis. Liver dysfunction induced by isotretinoin is rare but it poses a management dilemma. Read More

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http://dx.doi.org/10.1155/2019/9270827DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6662412PMC

Gas-Forming Liver Abscess versus Emphysematous Hepatitis: A Radiologic Diagnostic Dilemma-A Case Report and Review of the Literature.

Case Reports Hepatol 2019 16;2019:5274525. Epub 2019 Jul 16.

Department of Diagnostic Radiology, Saint George Hospital University Medical Center, University of Balamand, Achrafieh, Beirut, Lebanon.

A 38-year-old diabetic woman, with history of cholecystectomy and ventral hernia repair, was hospitalized due to sudden-onset abdominal pain and fever. Computed tomography revealed a mixed collection containing necrotic debris and emphysematous change in the left lobe of the liver mainly in segments II and III. These radiological findings suggested emphysematous hepatitis (EH). Read More

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http://dx.doi.org/10.1155/2019/5274525DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6662457PMC
July 2019
3 Reads

Hepatic Epithelioid Angiomyolipoma Treated with Laparoscopic Resection: Case Report and Review of the Literature.

Case Reports Hepatol 2019 1;2019:2362618. Epub 2019 Jul 1.

UMass Memorial Medical Center, Department of Surgery, Worcester, MA 01655, USA.

Hepatic angiomyolipoma is a rare primary liver tumor, with a radiographic appearance very similar to hepatocellular carcinoma. We present the case of a noncirrhotic patient with a liver tumor suspicious for HCC by imaging features. Liver biopsy demonstrated angiomyolipoma, and the patient successfully underwent a laparoscopic liver resection. Read More

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http://dx.doi.org/10.1155/2019/2362618DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6633875PMC
July 2019
1 Read

Management of Fish Bone-Induced Liver Abscess with Foreign Body Left In Situ.

Case Reports Hepatol 2019 11;2019:9075198. Epub 2019 Jun 11.

Division of Gastroenterology and Hepatology, Louisiana State University Health Science Center in Shreveport, LA, USA.

Pyogenic liver abscess, having experienced an evolving pathogenesis over the years, still remains a serious problem with significant morbidity. Iatrogenic and ascending biliary infections are the most common known etiologies for hepatic abscess. Here we report an interesting case of an elderly lady admitted with abdominal pain due to a pyogenic liver abscess in the left liver lobe which was attributed to perforation by an ingested fish bone. Read More

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http://dx.doi.org/10.1155/2019/9075198DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6594292PMC
June 2019
5 Reads

Autoimmune Hepatitis (AIH) in Acquired Immune Deficiency Syndrome (AIDS): A Case Report and Review of Literature.

Case Reports Hepatol 2019 9;2019:5326428. Epub 2019 Jun 9.

Department of Gastroenterology and Hepatology, Louisiana State University Health Sciences Center, Shreveport, LA, USA.

The common causes of abnormal liver chemistries in human immunodeficiency virus (HIV) infected patients are multifactorial. Diagnosis of autoimmune hepatitis (AIH) in HIV infected patients is intriguing but data is scarce. Unmasking of AIH during immune reconstitution in HIV patients after starting antiretroviral therapy is reported but not with advanced acquired immunodeficiency syndrome (AIDS). Read More

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http://dx.doi.org/10.1155/2019/5326428DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6590560PMC
June 2019
3 Reads

A Rare Case of Herpes Simplex Virus-2 Hepatitis with Negative Serology.

Case Reports Hepatol 2019 4;2019:4808143. Epub 2019 Jun 4.

Department of Medicine, Division of Infectious Diseases, University of Kentucky, Lexington, KY, USA.

Herpes simplex virus-2 (HSV2) hepatitis represents a rare but serious complication of HSV2 infection that can progress to acute liver failure (ALF). We describe a case of a pregnant teenager who presented with four days of fever, headache, malaise, nausea, and vomiting. She was initially misdiagnosed with sepsis of unclear source and treated with broad-spectrum antibiotics. Read More

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http://dx.doi.org/10.1155/2019/4808143DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6582860PMC
June 2019
8 Reads

Endometrioma of the Liver: A Case Report and Review of the Literature.

Case Reports Hepatol 2019 4;2019:4734606. Epub 2019 Jun 4.

Department of Gastroenterology and Liver Diseases, Los Angeles County Hospital/University of Southern California, USA.

Hepatic endometriosis is a rare form of endometriosis first described by Finkel in 1986. A thorough review of the literature revealed 28 cases of hepatic endometriosis. This unusual condition offers several diagnostic challenges due to its variable appearance on imaging and need for histologic analysis to establish a definitive diagnosis. Read More

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http://dx.doi.org/10.1155/2019/4734606DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6582834PMC
June 2019
1 Read

Turmeric Induced Liver Injury: A Report of Two Cases.

Case Reports Hepatol 2019 28;2019:6741213. Epub 2019 Apr 28.

Department of Gastroenterology, The Alfred Hospital, 55 Commercial Road, Melbourne, Victoria, Australia.

Turmeric is a commonly used oral herbal supplement with purported anti-inflammatory and antineoplastic properties. It is promoted as safe, with limited reports of severe adverse effects directly related to oral turmeric thus far in the literature. Herein we report two cases of turmeric supplement induced severe hepatitis. Read More

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http://dx.doi.org/10.1155/2019/6741213DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6535872PMC
April 2019
15 Reads

Lactulose to the Rescue: A Case of Toxic Hepatic Encephalopathy Caused by Portosystemic Shunting and Epistaxis in a Patient with Hereditary Hemorrhagic Telangiectasia.

Case Reports Hepatol 2019 26;2019:7573408. Epub 2019 Mar 26.

Geisinger Medical Center, Department of Gastroenterology, 100 N Academy Ave, Danville, PA 17822, USA.

Hereditary hemorrhagic telangiectasia (HHT) is an uncommon autosomal dominant disorder characterized by telangiectasias and arteriovenous malformations. Multiple organ systems are involved including the skin, lungs, gastrointestinal tract, and brain. Hepatic encephalopathy is an extremely rare complication of HHT and early diagnosis and treatment can be life-saving. Read More

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http://dx.doi.org/10.1155/2019/7573408DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6457288PMC
March 2019
5 Reads

Hepatopulmonary Fistula in a Colorectal Cancer Patient.

Case Reports Hepatol 2019 4;2019:1475209. Epub 2019 Mar 4.

Medical Oncology Department, Instituto Português de Oncologia do Porto, Francisco Gentil, Oporto, Portugal.

Cancer patients with liver metastasis may be candidates for liver surgery and local interventional techniques as part of their treatment. Although rare in this setting, hepatopulmonary fistula has been described as a possible complication. The clinical picture may be atypical, and, without specific treatment, it usually has a dismal prognosis. Read More

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http://dx.doi.org/10.1155/2019/1475209DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425290PMC
March 2019
2 Reads

Ruptured Multifocal Hepatic Aneurysms in a Woman with Systemic Lupus Erythematosus Successfully Treated with Transcatheter Arterial Embolization: A Case Report and Literature Review.

Case Reports Hepatol 2019 26;2019:6272419. Epub 2019 Feb 26.

Division of Allergy, Immunology and Rheumatology, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.

To present a first reported case of ruptured multifocal hepatic aneurysms in a woman with systemic lupus erythematosus (SLE) who was treated successfully with transcatheter arterial embolization (TAE) in literature, similar cases in the previous English literature were also reviewed and analyzed to summarize the clinical manifestations, management, and outcome in these patients. The data were gathered from the medical record and literature reviews were searched from PudMed. In our review, patients with SLE-related hepatic aneurysms were often middle-aged females. Read More

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http://dx.doi.org/10.1155/2019/6272419DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6413403PMC
February 2019
17 Reads

Chronic Hepatitis C with Cyanosis.

Case Reports Hepatol 2019 13;2019:6586478. Epub 2019 Jan 13.

Department of Medicine, Salmaniya Medical Complex, Manama, Bahrain.

Background: There are multiple aetiologies for dyspnea in patients with liver disease, including pneumonia, pulmonary embolism, hepatic hydrothorax, portopulmonary syndrome, and hepatopulmonary syndrome. The aim of this paper is to emphasize the importance of early diagnosis and management of hepatopulmonary syndrome.

Case Presentation: We report a case of a 65-year-old male who was known to have chronic hepatitis C presented with one-year history of shortness of breath and cyanosis. Read More

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http://dx.doi.org/10.1155/2019/6586478DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348809PMC
January 2019
20 Reads

Fatal Invasive Cryptococcal Infection in an HIV-Negative Elderly Patient with Decompensated Hepatic Cirrhosis.

Case Reports Hepatol 2018 31;2018:5174518. Epub 2018 Dec 31.

Department of Laboratory Medicine, Uji-Tokushukai Medical Center, Uji, 611-0042, Japan.

Diagnosis of invasive cryptococcal infection in apparently nonimmunocompromised patients is difficult and often delayed. Human immunodeficiency virus- (HIV-) negative patients with decompensated hepatic cirrhosis might be at high risk of cryptococcal infection. We report here an 82-year-old Japanese female with end-stage hepatic failure and undergoing renal dialysis, hospitalized with septic shock-like symptoms. Read More

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http://dx.doi.org/10.1155/2018/5174518DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333006PMC
December 2018
22 Reads

Fibrolamellar Hepatocellular Carcinoma and Noncirrhotic Hyperammonemic Encephalopathy.

Case Reports Hepatol 2018 9;2018:7521986. Epub 2018 Dec 9.

Department of Medicine, Division of Gastroenterology and Hepatology, Fundación Cardio Infantil, Bogotá D.C., Cundinamarca, Colombia.

Fibrolamellar hepatocarcinoma is an infrequent liver tumor, currently considered to be a variant different from hepatocarcinoma. The differences lie in genomic alterations, a greater prevalence of fibrolamellar hepatocarcinoma in young patients, and its lack of association with underlying liver disease. The clinical presentation is unspecific, with symptoms ranging from abdominal pain, malaise, and weight loss to atypical manifestation which include hyperammonemic encephalopathy. Read More

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http://dx.doi.org/10.1155/2018/7521986DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304646PMC
December 2018
9 Reads

Autoimmune Hepatitis with Concomitant Idiopathic Thrombocytopenic Purpura Diagnosed by Transjugular Liver Biopsy.

Case Reports Hepatol 2018 9;2018:5305691. Epub 2018 Dec 9.

Department of Gastroenterology and Medicine, Fukuoka University Faculty of Medicine, 7-45-1 Nanakuma, Jonan, Fukuoka 814-0180, Japan.

Patients with autoimmune hepatitis (AIH) may sometimes have concomitant idiopathic thrombocytopenic purpura (ITP). Severe thrombocytopenia in ITP interferes with percutaneous liver biopsy for pathological diagnosis of AIH. Here, we report a case of AIH with ITP in a 63-year-old woman. Read More

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https://www.hindawi.com/journals/crihep/2018/5305691/
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http://dx.doi.org/10.1155/2018/5305691DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304620PMC
December 2018
53 Reads

Acute Liver Injury Associated with Khat Use in a 24-Year-Old Male.

Case Reports Hepatol 2018 21;2018:2816907. Epub 2018 Nov 21.

Division of Gastroenterology, Department of Medicine, University of Alberta, Edmonton, AB, Canada.

Chewing khat leaves () is common cultural practice in Eastern African countries. Khat has been implicated in cases of acute liver injury, sometimes leading to liver failure and requiring transplantation. We report the case of a 24-year-old gentleman presenting with symptoms of acute liver failure. Read More

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http://dx.doi.org/10.1155/2018/2816907DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6280303PMC
November 2018
2 Reads

Liver Cholestasis Secondary to Syphilis in an Immunocompetent Patient.

Case Reports Hepatol 2018 22;2018:8645068. Epub 2018 Oct 22.

Department of Pathology, Louisiana State University Health Sciences Center, Shreveport, LA, USA.

Liver involvement is a known feature of secondary syphilis. The prevalence of hepatitis in secondary syphilis ranges broadly from 1 to 50%. We report a case of a 37-year-old man with type 1 diabetes mellitus and sickle cell trait presenting with jaundice and acute liver cholestasis. Read More

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https://www.hindawi.com/journals/crihep/2018/8645068/
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http://dx.doi.org/10.1155/2018/8645068DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6217883PMC
October 2018
27 Reads

Development of Focal Nodular Hyperplasia after Cyclophosphamide-Based Chemotherapy in a Patient with Breast Cancer.

Case Reports Hepatol 2018 22;2018:5409316. Epub 2018 Oct 22.

Department of Breast Surgery, The Third Affiliated Hospital of Suzhou University, 185 Juqian Road, 213003 Changzhou, China.

Focal nodular hyperplasia (FNH) is the second most common liver cell-derived benign tumor. It is postulated that chemotherapy-induced hepatic circulatory abnormalities, like sinusoidal obstruction syndrome (SOS), could lead to the development of FNH. Cyclophosphamide was also reported to induce SOS in a synergistic effect with total body irradiation. Read More

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http://dx.doi.org/10.1155/2018/5409316DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6217880PMC
October 2018
3 Reads

Hepatic Sclerosing Hemangioma with Predominance of the Sclerosed Area Mimicking a Biliary Cystadenocarcinoma.

Case Reports Hepatol 2018 4;2018:7353170. Epub 2018 Oct 4.

Department of Diagnostic Pathology, Juntendo University Nerima Hospital, Japan.

We report here an extremely rare case of hepatic sclerosing hemangioma mimicking a biliary cystadenocarcinoma. A previously healthy 39-year-old woman was referred to our hospital because of a large tumor in the liver. Abdominal computed tomography revealed early peripheral ring enhancement in the arterial phase and slight internal heterogeneous enhancement in the delayed phase. Read More

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https://www.hindawi.com/journals/crihep/2018/7353170/
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http://dx.doi.org/10.1155/2018/7353170DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6193354PMC
October 2018
9 Reads

Anastomotic Biliary Stricture Development after Liver Transplantation in the Setting of Retained Prophylactic Intraductal Pediatric Feeding Tube: Case and Review.

Case Reports Hepatol 2018 30;2018:4707389. Epub 2018 Sep 30.

Division of Gastroenterology and Hepatology, Department of Internal Medicine, University of California Davis Medical Center, Sacramento, California, USA.

The biliary anastomosis remains a common site of postoperative complications in liver transplantation (LT). Biliary complications have indeed been termed the "Achilles' heel" of LT, and while their prevention, diagnosis, and treatment have continued to evolve over the last two decades, various challenges and uncertainties persist. Here we present the case of a 33-year-old man who, 10 years after undergoing LT for idiopathic recurrent intrahepatic cholestasis, was noted to have developed pruritus and abnormalities in serum liver biochemistries during routine post-liver transplant follow-up. Read More

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https://www.hindawi.com/journals/crihep/2018/4707389/
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http://dx.doi.org/10.1155/2018/4707389DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6186356PMC
September 2018
11 Reads

Acute Liver Failure due to Disseminated Varicella Zoster Infection.

Case Reports Hepatol 2018 27;2018:1269340. Epub 2018 Sep 27.

Methodist Hospitals of Dallas, 1441 N Beckley Ave Dallas, TX 75203, USA.

Acute liver failure (ALF) can be due to numerous causes and result in fatality or necessitate liver transplantation if left untreated. Possible etiologies of ALF include ischemia, venous obstruction, medications, toxins, autoimmune hepatitis, metabolic and infectious causes including hepatitis A-E, varicella-zoster virus (VZV), cytomegalovirus (CMV), herpes simplex virus (HSV), Epstein-Barr virus (EBV), and adenovirus with VZV being the most rarely reported. Pathognomonic skin lesions facilitate diagnosis of VZV hepatitis, but definitive diagnosis is secured with liver biopsy, tissue histopathology, culture, and specific VZV polymerase chain reaction (PCR). Read More

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https://www.hindawi.com/journals/crihep/2018/1269340/
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http://dx.doi.org/10.1155/2018/1269340DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6180957PMC
September 2018
20 Reads

Treatment of Chronic Hepatitis C Can Improve Glycemic Control in Patients with Type 2 Diabetes.

Case Reports Hepatol 2018 17;2018:5260510. Epub 2018 Sep 17.

University of Health Sciences, Fatih Sultan Mehmet Training and Research Hospital, Department of Internal Medicine, Istanbul, Turkey.

A 73-year-old female patient with a history of type 2 DM for seven years was admitted to our out-patient clinic with a complaint of frequent hypoglycemic episodes. She was receiving basal- bolus insulin treatment. She underwent liver transplantation 20 months ago due to end stage liver disease caused by HCV infection genotype 1b. Read More

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https://www.hindawi.com/journals/crihep/2018/5260510/
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http://dx.doi.org/10.1155/2018/5260510DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6166368PMC
September 2018
5 Reads

Chronic, Recreational Chloroform-Induced Liver Injury.

Case Reports Hepatol 2018 10;2018:1619546. Epub 2018 Sep 10.

Department of Digestive Diseases, West Virginia University School of Medicine, Morgantown, WV, USA.

Historically used as an anesthetic, chloroform is a halogenated hydrocarbon that is associated with central nervous system depression, arrhythmias, and hepatotoxicity. It is no longer used clinically, but accidental and intentional poisonings still occur. We report a case of chronic chloroform abuse leading to severe hepatotoxicity in a 26-year-old male graduate student. Read More

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http://dx.doi.org/10.1155/2018/1619546DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6151676PMC
September 2018
4 Reads

The Spiraling Case of a Yellow Chef: Isolated Hyperbilirubinemia.

Case Reports Hepatol 2018 23;2018:5876718. Epub 2018 Aug 23.

Division of Gastroenterology, Hepatology and Endoscopy, Brigham and Women's Hospital, Boston, MA, USA.

Leptospirosis is a common bacterial disease in tropical regions of the world due to greater exposure to rodents and domestic animals; however, this condition can also occur in US urban areas, though it often goes unrecognized. Gastrointestinal symptoms are very commonly seen, and icteric leptospirosis is often confused for other conditions resulting in delayed diagnosis and worse outcomes. As mortality increases with more extensive hepatic involvement, gastroenterologists should be aware of the constellation of gastrointestinal symptoms related to leptospirosis, as it can occur in the absence of classic exposure history. Read More

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http://dx.doi.org/10.1155/2018/5876718DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6126086PMC
August 2018
37 Reads

Resolution of Crizotinib-Associated Fulminant Hepatitis following Cessation of Treatment.

Case Reports Hepatol 2018 5;2018:3413592. Epub 2018 Aug 5.

Department of Medicine, Division of Gastroenterology and Hepatology, Stanford University School of Medicine, Stanford, CA 94305, USA.

Targeted cancer treatments offer the prospect of precise inhibition of tumor growth without the untoward off-target toxicity of traditional chemotherapies. Still, unintended, often idiosyncratic side effects, such as drug-induced liver injury, can occur. We discuss the case of a 26-year-old female with a history of -rearranged lung adenocarcinoma, undergoing treatment with the tyrosine kinase inhibitor crizotinib, who presented to our hospital with abdominal pain and scleral icterus. Read More

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http://dx.doi.org/10.1155/2018/3413592DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6098865PMC
August 2018
9 Reads

Pyogenic Liver Abscess Caused by Methicillin-Susceptible in a 21-Year-Old Male.

Case Reports Hepatol 2018 19;2018:9868701. Epub 2018 Jun 19.

Department of Gastroenterology and Hepatology, Louisiana State University Health Sciences Center, Shreveport, LA, USA.

Liver abscesses are the most common types of visceral abscesses. Pyogenic liver abscesses, a particular type of liver abscesses, are uncommonly encountered. We present a rare case of pyogenic liver abscess caused by methicillin-susceptible in a young man. Read More

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https://www.hindawi.com/journals/crihep/2018/9868701/
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http://dx.doi.org/10.1155/2018/9868701DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6029455PMC
June 2018
16 Reads

Rupture of Hepatocellular Carcinoma after Transarterial Chemoembolization followed by Massive Gastric Bleeding.

Case Reports Hepatol 2018 4;2018:4576276. Epub 2018 Jun 4.

Department of Emergent and Critical Care Medicine, Saiseikai Yokohamashi Tobu Hospital, 3-6-1, Shimosueyoshi, Tsurumi, Yokohama-city, Kanagawa 230-8765, Japan.

Introduction: Transarterial chemoembolization (TACE) is the first-line therapy for patient with unresectable hepatocellular carcinoma (HCC). Although TACE is a generally safe procedure, major complications can be occurred. We describe a patient with rupture of HCC after TACE followed by gastric bleeding. Read More

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http://dx.doi.org/10.1155/2018/4576276DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6008880PMC
June 2018
3 Reads

Hepatic Iron Overload following Liver Transplantation from a C282Y/H63D Compound Heterozygous Donor.

Case Reports Hepatol 2018 31;2018:4298649. Epub 2018 May 31.

Liver Disease Center, Sheba Medical Center, Ramat Gan, Israel.

Hereditary hemochromatosis (HH) is a genetic disease associated with progressive iron overload, eventually leading in some cases to damage of parenchymal organs, such as the liver, pancreas, and heart. Although the gene had been identified (HFE), HH pathogenesis remains to be fully elucidated. We report here, for the first time, a case of inadvertent transplantation of a liver from a donor with C282Y/H63D compound heterozygosity into a nonhemochromatotic 19-year-old Caucasian male recipient with primary sclerosing cholangitis. Read More

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http://dx.doi.org/10.1155/2018/4298649DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6000855PMC
May 2018
6 Reads

Acute Liver Failure among Patients on Efavirenz-Based Antiretroviral Therapy.

Case Reports Hepatol 2018 10;2018:1270716. Epub 2018 May 10.

Department of Internal Medicine, Intermediate Hospital Oshakati, Oshakati, Namibia.

Objectives: To describe the clinical characteristics of patients presenting with fulminant liver failure after varying periods of exposure to Efavirenz containing antiretroviral medications.

Methods: We report a series of 4 patients with human immunodeficiency virus (HIV) infection who were admitted with acute liver failure (ALF) over a 6-month period. All these patients had been treated with a range of Efavirenz containing antiretroviral regimens and were negative for hepatitis A, B, and C infections as well as other opportunistic infections, all were negative for autoimmune hepatitis, and none had evidence of chronic liver disease or use of alcohol or herbal medications. Read More

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http://dx.doi.org/10.1155/2018/1270716DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5971290PMC
May 2018
16 Reads

Refractory Hepatic Hydrothorax: A Rare Complication of Systemic Sclerosis and Presinusoidal Portal Hypertension.

Case Reports Hepatol 2018 30;2018:2704949. Epub 2018 Apr 30.

Department of Pathology, Greenville Health System, University of South Carolina School of Medicine Greenville, Greenville, SC, USA.

We report on a rare case of refractory hepatic hydrothorax in an individual with Scleroderma/CREST syndrome and noncirrhotic portal hypertension. Portal pressure measurements revealed a normal transjugular hepatic venous portal pressure gradient, mild pulmonary hypertension, and an unremarkable liver biopsy except for mild sinusoidal dilation. Pulmonary hypertension, cardiac diastolic dysfunction, and chronic kidney disease were determined to be the causes of his refractory pleural effusions and ascites. Read More

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http://dx.doi.org/10.1155/2018/2704949DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5952433PMC
April 2018
39 Reads

Incidental Metastatic Meningioma Presenting as a Large Liver Mass.

Case Reports Hepatol 2018 7;2018:1089394. Epub 2018 May 7.

Department of Pathology, MedStar Georgetown University Hospital, Washington, DC, USA.

Meningiomas are slow growing neoplasms of the central nervous system (CNS). Most of the tumors are benign and distant metastasis from a benign meningioma is rare. Metastasis to the liver, although rare, usually presents with hypoglycemia or occurs in conjunction with a clinical history of an intracranial meningioma or following the resection of a prior CNS meningioma, thus making clinical diagnosis relatively easy. Read More

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http://dx.doi.org/10.1155/2018/1089394DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5964563PMC
May 2018
3 Reads

Young Man with Hepatomegaly: A Case of Glycogenic Hepatopathy.

Case Reports Hepatol 2018 15;2018:6037530. Epub 2018 Apr 15.

Department of Critical Care, Zayed Military Hospital, Abu Dhabi, UAE.

Glycogenic hepatopathy is a rare but potentially reversible condition characterized by hepatomegaly and elevated liver enzymes occurring in poorly controlled type 1 diabetes mellitus patients and often requires a liver biopsy to confirm the diagnosis. We present the case of a young man who was admitted with diabetic ketoacidosis in the setting of poorly controlled diabetes mellitus type 1 and was noted to have significantly elevated transaminases that continued to worsen despite appropriate treatment of the diabetic ketoacidosis. A liver biopsy confirmed the diagnosis of glycogenic hepatopathy and the patient improved with diabetes control. Read More

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http://dx.doi.org/10.1155/2018/6037530DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5925151PMC
April 2018
1 Read

Tubulocystic Carcinoma of the Bile Duct.

Case Reports Hepatol 2018 1;2018:2304610. Epub 2018 Apr 1.

Department of Surgery 1, School of Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu-shi, Fukuoka 807-0804, Japan.

Tubulocystic carcinoma of the bile duct is extremely rare and has not been reported in the literature. We reported a case of cystic neoplasm of the liver with distinct histopathological features that could not be clearly classified as of either mucinous or intraductal papillary neoplasm. A 68-year-old Japanese patient had a multicystic biliary tumor within the liver. Read More

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http://dx.doi.org/10.1155/2018/2304610DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5899877PMC
April 2018
20 Reads

Castleman's Disease and Posttransplant Lymphoproliferative Disorder after Liver Transplant: 3-Year Follow-Up.

Case Reports Hepatol 2018 28;2018:9324872. Epub 2018 Jan 28.

Division of Gastroenterology & Hepatology, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE, USA.

A 59-year-old male with a history of hepatitis C cirrhosis and history of hepatitis B exposure presented 8 months after orthotopic liver transplant (LT) with fever, fatigue, myalgia, night sweats, nonproductive cough, and shortness of breath. Bone marrow biopsy for pancytopenia was positive for Epstein-Barr virus (EBV) DNA. Lymph node biopsy for lymphadenopathy on imaging showed human herpes virus 8 (HHV8) associated Castleman's disease. Read More

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http://dx.doi.org/10.1155/2018/9324872DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5896418PMC
January 2018
6 Reads

Hepatotoxicity Associated with Use of the Weight Loss Supplement : A Case Report and Review of the Literature.

Case Reports Hepatol 2018 12;2018:6483605. Epub 2018 Mar 12.

Department of Gastroenterology and Hepatology, University of Nebraska Medical Center, 982000 Nebraska Medical Center, Omaha, NE 68198, USA.

The use of herbal and dietary supplements for weight loss is becoming increasingly common as obesity is becoming major health problem in the United States. Despite the popularity of these natural supplements, there are no guidelines for their therapeutic doses and their safety is always a concern. extract with its active ingredient "hydroxycitric acid" is a component of many weight loss regimens. Read More

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http://dx.doi.org/10.1155/2018/6483605DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5867608PMC
March 2018
3 Reads

Postinfantile Giant Cell Hepatitis with Features of Acute Severe Autoimmune Hepatitis Probably Triggered by Diclofenac in a Patient with Primary Myelofibrosis.

Case Reports Hepatol 2018 11;2018:9793868. Epub 2018 Mar 11.

Department of Medicine and Research Laboratory of Internal Medicine, School of Medicine, University of Thessaly, Larissa, Greece.

Giant cell hepatitis (GCH) is commonly reported in neonatal and infantile liver diseases but rarely in adults where the term postinfantile GCH (PIGCH) is used. PIGCH is associated with many diseases, including drugs toxicity, viruses, and autoimmune liver diseases, with autoimmune hepatitis (AIH) being the most prevalent. We present a case of PIGCH in a 76-year-old female without known history of liver disease who suffered from an acute severe episode of hepatitis. Read More

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http://dx.doi.org/10.1155/2018/9793868DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5866856PMC
March 2018
4 Reads