469 results match your criteria Case reports in hematology[Journal]
Case Rep Hematol 2018 16;2018:7865325. Epub 2018 May 16.
Division of Blood and Marrow Transplant, University of Louisville, Louisville, KY, USA.
Erdheim-Chester disease (ECD) is a rare non-Langerhans cell histiocyte disorder most commonly characterized by multifocal osteosclerotic lesions of the long bones demonstrating sheets of foamy histiocyte infiltrates on biopsy with or without histiocytic infiltration of extraskeletal tissues. ECD can be difficult to diagnose since it is a very rare disease that can affect many organ systems. Diagnosis is based on the pathologic evaluation of involved tissue interpreted within the clinical context. Read More
Case Rep Hematol 2018 13;2018:9807047. Epub 2018 May 13.
Adult Hematologic Malignancies and Stem Cell Transplant Section, Seidman Cancer Center, University Hospitals Cleveland Medical Center, Cleveland, OH, USA.
Great strides have been made in the treatment of acute myeloid leukemia (AML) resulting in increased number of survivors over all age groups, but especially in patients of reproductive age. Given the gonadotoxicity of high-dose induction chemotherapy and subsequent allogeneic stem cell transplant, it is paramount that fertility preservation options are discussed and explored at the time of diagnosis as fertility preservation has been associated with greater quality of life in survivors. Starting the conversation early is especially important for female patients given the time needed for all currently available fertility preservation techniques. Read More
Case Rep Hematol 2018 9;2018:8713020. Epub 2018 May 9.
Department of Haematology, Beaumont Hospital, Dublin 9, Ireland.
Although transformation of the myeloproliferative neoplasms (MPNs) to acute myeloid leukemia (AML) is well documented, development of an MPN in patients previously treated for, and in remission from, AML is exceedingly rare. A case is described in which a patient was successfully treated for AML and in whom a V617F-positive MPN was diagnosed after seven years in remission. Retrospective evaluation of the V617F detected a low allele burden at AML diagnosis and following one course of induction chemotherapy. Read More
Case Rep Hematol 2018 29;2018:3604298. Epub 2018 Apr 29.
Division of Hematology and Oncology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.
We report the case of a 73-year-old male with primary myeloid sarcoma (MS) of the prostate. He underwent remission-induction chemotherapy followed by conventional consolidation for acute myeloid leukemia (AML). One year after initial diagnosis, he was without evidence of AML, the longest reported period of time in the literature for a case of primary MS of the prostate. Read More
Case Rep Hematol 2018 6;2018:2849869. Epub 2018 May 6.
Department of Internal Medicine, Louisiana State University Health Sciences Center, Shreveport, LA, USA.
Rhabdomyolysis is a life-threatening syndrome due to breakdown of the skeletal muscle. It can be caused by massive trauma and crush injuries or occur as a side effect of medications. Here, we describe a case of a 33-year-old male with human immunodeficiency virus (HIV) and newly diagnosed chronic myeloid leukemia (CML) with severe life-threatening rhabdomyolysis due to a rare offending agent. Read More
Case Rep Hematol 2018 12;2018:3915319. Epub 2018 Apr 12.
Department of Internal Medicine, Division of Hematology and Oncology, Hospital of the University of Pennsylvania, Philadelphia, PA, USA.
Rosai-Dorfman disease (RDD) is a rare, nonmalignant disorder of histiocyte proliferation typically involving the cervical lymph nodes. However, a subset of patients with RDD will display extranodal manifestations that are highly variable in presentation, more challenging to diagnose, and less likely to spontaneously regress compared to nodal disease. While case reports of extranodal involvement in nearly every organ system exist, documented instances of mediastinal and pulmonary artery involvement are particularly rare. Read More
Case Rep Hematol 2018 11;2018:3465351. Epub 2018 Apr 11.
Department of Hematology and Oncology, Staten Island University Hospital, 475 Seaview Avenue, Staten Island, New York, NY 10305, USA.
Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening disorder that can be familial in etiology or a result of infections, malignancy, and autoimmune or inflammatory disorders. Disseminated intravascular coagulation (DIC) is common in patients admitted to intensive care units and can confound and delay the diagnosis of HLH. We present a case of a 69-year-old female who presented with dyspnea and malaise. Read More
Case Rep Hematol 2018 1;2018:9764049. Epub 2018 Apr 1.
Section of Medical Oncology, Sidney Kimmel Comprehensive Cancer Center at John Hopkins Hospital, Baltimore, MD, USA.
A 47-year-old male presented with a groin lesion in 2011. Initial treatment with antifungals and vinegar was unsuccessful. In 2016, biopsy of this lesion was pursued with diagnosis of extramammary Paget's disease (EMPD). Read More
Case Rep Hematol 2018 1;2018:1041396. Epub 2018 Apr 1.
Department of Vascular Medicine, Princess Alexandra Hospital, Brisbane, QLD, Australia.
Catastrophic antiphospholipid syndrome is a rare condition with high morbidity and mortality. We present a refractory case of catastrophic antiphospholipid syndrome with a view to highlight the importance of early identification and aggressive treatment of this condition. A 36-year-old female presented with clinical manifestations of multiorgan vascular occlusion with a known history of primary antiphospholipid syndrome. Read More
Case Rep Hematol 2018 12;2018:9052314. Epub 2018 Feb 12.
Division of Hematology and Oncology, Department of Medicine, University of Florida, Gainesville, FL, USA.
Lenalidomide maintenance following autologous stem cell transplant (ASCT) is considered the standard of care for eligible patients with multiple myeloma (MM). A recent meta-analysis has provided additional evidence that lenalidomide maintenance is associated with a higher incidence of second primary malignancies, including both hematologic and solid malignancies. Acute lymphoblastic leukemia (ALL) as a second primary malignancy is rarely described in the literature. Read More
Case Rep Hematol 2018 23;2018:1791627. Epub 2018 Jan 23.
Carol Davila University of Medicine and Pharmacy, Bucharest, Romania.
Kikuchi-Fujimoto disease (KFD) or histiocytic necrotizing lymphadenitis is a rare disease that is frequently underdiagnosed due to clinical features that are similar to those of non-Hodgkin lymphomas, systemic lupus erythematosus (SLE), or infectious reactive lymphadenopathy. An excisional biopsy is required. We report a young Caucasian female diagnosed with KFD with skin lesions, complicating with SLE. Read More
Case Rep Hematol 2018 26;2018:7169897. Epub 2018 Mar 26.
Department of Pharmacy, Mayo Clinic, Rochester, MN, USA.
High-dose methotrexate (MTX; ≥1 g/m) is a renally eliminated and nephrotoxic first-line therapy for central nervous system (CNS) lymphoma. Creatinine-based estimation of renal function is the recommended approach to dosing MTX in these cases, but nonrenal determinants of creatinine production and elimination in cancer patients such as malnutrition and cachexia lead to overestimation of glomerular filtration rate (GFR) by this method and a heightened risk for drug toxicity. Serum cystatin C is one of the first readily available, relatively inexpensive, endogenous biomarkers to emerge as a practical adjunct to creatinine for estimation of renal function for drug dosing. Read More
Case Rep Hematol 2018 13;2018:9531484. Epub 2018 Mar 13.
Department of Hematology, Faculty of Medicine, Trakya University, Edirne, Turkey.
Invasive fungal infections bring serious mortality and morbidity during the treatment of acute myeloid leukemia. Especially, mold infections are challenging, and each case is unique in feature. These cases are usually fatal, and there is no consensus regarding optimal treatment. Read More
Case Rep Hematol 2018 13;2018:5471368. Epub 2018 Mar 13.
Division of Hematology and Medical Oncology, Loma Linda Veterans Administration Medical Center, Loma Linda, CA, USA.
Diffuse large B-cell lymphoma (DLBCL) is a molecularly heterogeneous disease consisting of different subtypes with varying clinical behaviors. For example, the activated B-cell-like (ABC) type of DLBCL has lower cure rates with traditional chemotherapy regimens. The molecular pathway promoting tumorigenic growth of the ABC type includes a dependence on intracellular signaling by Bruton's agammaglobulinemia tyrosine kinase (BTK). Read More
Case Rep Hematol 2018 11;2018:5034741. Epub 2018 Mar 11.
Interfaith Medical Center, Brooklyn, NY, USA.
Association of thymoma with myasthenia gravis, pure red cell aplasia, and aplastic anemia is well documented. However, thymoma complicated by acquired amegakaryocytic thrombocytopenia (AAMT) is rarely reported. Here, we present a case of a 60-year-old male with past medical history of recurrent invasive thymoma who presented with cough and blood in sputum. Read More
Case Rep Hematol 2018 5;2018:6063519. Epub 2018 Mar 5.
Division of Hematology and Oncology, Sanford USD School of Medicine, Sioux Falls, SD, USA.
Background: Epstein-Barr virus- (EBV-) associated lymphoproliferative disease (LPD) is a rare condition, usually occurring in immunocompromised patients. We report a case of EBV-associated LPD in a patient with severe celiac disease, the first report to describe this syndrome in a patient with this diagnosis.
Case Summary: A 69-year-old Caucasian woman with recent diagnosis of celiac sprue presented to our hospital with persistent diarrhea, abdominal pain, weight loss, and fatigue despite adherence to gluten-free diet for a number of weeks prior to presentation. Read More
Case Rep Hematol 2018 4;2018:1913938. Epub 2018 Mar 4.
King Faisal Specialist Hospital and Research Center, P.O. Box 3354, Riyadh 11211, Saudi Arabia.
A 19-year-old patient with relapsed acute myeloid leukemia (AML) developed severe and prolonged cytopenia and unexplained jaundice and fever after salvage chemotherapy. His workup revealed hemophagocytosis on the bone marrow biopsy. He was treated for HLH (hemophagocytic lymphohistiocytosis) secondary to AML and chemotherapy. Read More
Case Rep Hematol 2018 28;2018:9191582. Epub 2018 Feb 28.
Moffitt Cancer Center, Tampa, FL, USA.
Nonhepatosplenic/noncutaneous peripheral T-cell lymphoma (NHNC PTCL) represents a miscellaneous group of unrelated T-cell lymphomas of which only isolated cases have been reported. We describe two cases of transformation from T-lymphoblastic leukemia/lymphoma to NHNC PTCL. Transformation into more aggressive disease is a rare event in T-cell lineage-derived hematologic malignancies compared to B-cell neoplasms. Read More
Case Rep Hematol 2018 22;2018:4378310. Epub 2018 Feb 22.
Department of Haematology, St. James's Hospital, Dublin 8, Ireland.
The term "idiopathic erythrocytosis (IE)" is applied to those cases where a causal clinical or pathological event cannot be elucidated and likely reflects a spectrum of underlying medical and molecular abnormalities. The clinical course of a patient with IE is described manifesting as a persistent erythrocytosis with a low serum erythropoietin level, mild eosinophilia, and with evidence of a thrombotic event. The patient subsequently developed a myelodysplasic syndrome (MDS) and acute myeloid leukemia (AML), an event not observed in erythrocytosis patients other than those with polycythemia vera (PV). Read More
Case Rep Hematol 2018 19;2018:8159093. Epub 2018 Feb 19.
Department of Hematology, Faculty of Medicine, Ankara University, Ankara, Turkey.
Inherited and/or acquired thrombophilic defects can result in venous or arterial thrombosis. This case report describes arterial thrombotic episodes triggered by the ingestion of an aphrodisiac remedy containing cantharidin in a 46-year-old female patient later discovered to be heterozygous for prothrombin G20210A mutation and seropositive for anti-2 glycoprotein-I (anti-2-GPI) antibodies of IgA isotype. Read More
Case Rep Hematol 2018 19;2018:4507638. Epub 2018 Feb 19.
Department of Neuroradiology, Hospital Universitari del SagratCor, Universitat de Barcelona, Barcelona, Catalonia, Spain.
In the last decade, the clinical relevance for developing safer oral anticoagulants prompted the development of new classes of drugs that have shown a lower risk of life-threatening bleeding events as compared to standard warfarin. Nontraumatic spinal subdural hematoma is an uncommon urgent complication that can be associated with the use of these agents. An unusual case of spinal subdural hematoma related to apixaban treatment for nonrheumatic atrial fibrillation is reported here. Read More
Case Rep Hematol 2018 18;2018:3890361. Epub 2018 Feb 18.
Serviço de Hematologia Clínica, Hospital de Santo António (HSA), Centro Hospitalar do Porto (CHP), Porto, Portugal.
Introduction: Mast cell (MC) leukemia (MCL) is extremely rare. We present a case of MCL diagnosed concomitantly with acute myeloblastic leukemia (AML).
Case Report: A 41-year-old woman presented with asthenia, anorexia, fever, epigastralgia, and diarrhea. Read More
Case Rep Hematol 2018 31;2018:9840405. Epub 2018 Jan 31.
UO di Ematologia e CTMO, Azienda Ospedaliero-Universitaria di Parma and Department of Medicine and Surgery, University of Parma, Parma, Italy.
Muscle involvement in AL amyloidosis is a rare condition, and the diagnosis of amyloid myopathy is often delayed and underdiagnosed. Amyloid myopathy may be the initial manifestation and may precede the diagnosis of systemic AL amyloidosis. Here, we report the case of a 73-year-old man who was referred to our center for a monoclonal gammopathy of undetermined significance (MGUS) diagnosed since 1999. Read More
Case Rep Hematol 2018 31;2018:8765285. Epub 2018 Jan 31.
Bayer U.S. LLC, 100 Bayer Boulevard, Whippany, NJ 07891-0915, USA.
Acute lymphoblastic leukemia is commonly cured when diagnosed in the pediatric population. It portends a poorer prognosis if present in adult patients. Although adults frequently achieve complete remission, relapse rates are substantial, particularly among the elderly and high-risk populations. Read More
Case Rep Hematol 2018 30;2018:7973297. Epub 2018 Jan 30.
Department of Hematology, Radboud University Medical Center, Nijmegen, Netherlands.
We present a rare case of acquired von Willebrand syndrome (AVWS) caused by a mantle cell lymphoma. A 61-year-old male suffered from recurrent bleeding symptoms since a few months. Initially, physical examination was normal. Read More
Case Rep Hematol 2018 13;2018:6730567. Epub 2018 Feb 13.
Radiation Oncology Department, Hospital Universitario 12 de Octubre, Madrid, Spain.
Here, we describe the case of a 66-year-old male diagnosed with multiple myeloma who presented with generalized tonic-clonic seizures. Magnetic resonance imaging demonstrated a right solid extra-axial parieto-occipital lesion with typical characteristics of meningeal myelomatosis. Biopsy was performed, which diagnosed a dural plasmacytoma. Read More
Case Rep Hematol 2018 30;2018:5616898. Epub 2018 Jan 30.
Cunningham Pathology Associates, Birmingham, AL, USA.
infections have been described in patients with diverse types of malignancy, especially leukemia. We report the case of a 65-year-old man with previously untreated hairy cell leukemia characterized by CD5 positivity and trisomy 12 (3% of blood lymphocytes) who developed bacteremia due to serotype 1/2b. We summarize clinical features and treatment of this patient and five previously reported patients with hairy cell leukemia who also had infections. Read More
Case Rep Hematol 2018 12;2018:9590469. Epub 2018 Feb 12.
Mashhad University of Medical Sciences, Mashhad, Iran.
Acute myelogenous leukemia (AML) accounts for 1.2% of all cancer deaths. Relapse is the major cause of treatment failure in acute myeloid leukemia (AML) patients. Read More
Case Rep Hematol 2018 28;2018:9368451. Epub 2018 Jan 28.
Division of Blood and Marrow Transplant, University of Louisville, Louisville, KY, USA.
Primary effusion lymphoma (PEL) is a unique form of non-Hodgkin lymphoma, usually seen in severely immunocompromised, HIV-positive patients. PEL is related to human herpesvirus-8 (HHV-8) infection, and it usually presents as a lymphomatous body cavity effusion in the absence of a solid tumor mass. There have been very few case reports of HIV-positive patients with HHV-8-positive solid tissue lymphomas not associated with an effusion (a solid variant of PEL). Read More
Case Rep Hematol 2018 11;2018:7341835. Epub 2018 Feb 11.
Department of Internal Medicine, Creighton University, Omaha, NE, USA.
A sixty-eight-year-old male with a past medical history of recurrent cocaine use presented to the emergency department with recurrent diarrhea and was found to have a white blood cell (WBC) count of 1.9 × 10/L with agranulocytosis (absolute neutrophil count (ANC) of 95 cell/mm). At admission, the patient disclosed that he used cocaine earlier during the day, and a urine drug screen tested positive for this. Read More
Case Rep Hematol 2018 23;2018:5895903. Epub 2018 Jan 23.
Department of Hematology, The First People's Hospital of Changzhou, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu, China.
Multicentric Castleman disease (MCD) is a rare nonmalignant lymphoproliferative disorder presenting systemic symptoms such as fever, night sweats, fatigue, anemia, effusions, and multifocal lymphadenopathy. The etiology of MCD has not been clarified to date. The coexistence of MCD with chronic myelomonocytic leukemia (CMML) has been rarely reported. Read More
Case Rep Hematol 2018 23;2018:5217301. Epub 2018 Jan 23.
Department of Respiratory Medicine, Okinawa Prefectural Nanbu Medical Center & Children's Medical Center, Okinawa, Japan.
Protein S (PS) deficiency, an autosomal dominant hereditary thrombophilia, is more prevalent in East Asian populations than in Caucasians. PS-deficient patients have historically been administered a heparin product followed by warfarin for the treatment and secondary prevention of venous thromboembolism (VTE). However, warfarin can be ineffective or causes detrimental effects in rare cases. Read More
Case Rep Hematol 2018 11;2018:4726451. Epub 2018 Feb 11.
Division of Hematology, Department of Medicine, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Pericarditis/pericardial effusion (PC/PEEF) is a rare but fatal complication of cytosine arabinoside (Ara-C). We report an acute myeloid leukemia (AML) patient who developed massive pericardial effusion after a second Ara-C exposure. As Ara-C was most beneficial in controlling the leukemia, she was treated with a further cycle of Ara-C along with dexamethasone to prevent the complication from reoccurring. Read More
Case Rep Hematol 2018 21;2018:2414278. Epub 2018 Jan 21.
Department of Radiation Oncology, Mount Sinai Downtown, New York, NY 10003, USA.
We are reporting the case of a 58-year-old woman with history of bilateral silicone breast implants for cosmetic augmentation. At 2-year interval from receiving the breast implants, she presented with swelling of the right breast with associated chest wall mass, effusion around the implant, and axillary lymphadenopathy. Pathology confirmed breast implant-associated anaplastic large cell lymphoma (stage III, T4N2M0, using BIA-ALCL TNM staging and stage IIAE, using Ann-Arbor staging). Read More
Case Rep Hematol 2018 11;2018:3106852. Epub 2018 Jan 11.
Hurley Medical Center, Michigan State University, East Lansing, MI, USA.
Nivolumab is a monoclonal antibody against the programmed death protein 1 and is used for patients with advanced melanoma. It is associated with potentially immune-related adverse events, including disorders of the skin, GI tract, and the thyroid; these disorders were successfully treated with prednisone and infliximab. Other immunotherapeutic agents were observed to induce the formation of antiphospholipid antibody (APA) including -interferon and interleukin-2. Read More
Case Rep Hematol 2018 10;2018:9501863. Epub 2018 Jan 10.
Department of Medicine, New York University Langone Health, Division of Hematology, 550 First Avenue, New York, NY, USA.
Unfractionated heparin and low-molecular-weight heparins are commonly used as thromboprophylaxis for hospitalized patients. Though generally considered safe at prophylactic doses, cases of catastrophic hemorrhage have been reported. The proposed mechanism involves bioaccumulation of heparin through saturation of the rapid-elimination pathway in its metabolism. Read More
Case Rep Hematol 2018 10;2018:7809535. Epub 2018 Jan 10.
Department of Medicine, Reading Hospital, West Reading, PA, USA.
Acquired angioedema due to C1 inhibitor deficiency (C1INH-AAE) is a rare and potentially fatal syndrome of bradykinin-mediated angioedema characterized by episodes of angioedema without urticaria. It typically manifests with nonpitting edema of the skin and edema in the gastrointestinal (GI) tract mucosa or upper airway. Edema of the upper airway and tongue may lead to life-threatening asphyxiation. Read More
Case Rep Hematol 2018 10;2018:5846398. Epub 2018 Jan 10.
Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA, USA.
A 41-year-old female presented to the hospital with sore throat and shortness of breath. She was hypoxic with an oxygen saturation of 87% in room air. Physical examination revealed swollen uvula with exudates. Read More
Case Rep Hematol 2018 11;2018:8097965. Epub 2018 Jan 11.
Department of Pathology, John H. Stroger Jr. Hospital of Cook County, Chicago, IL, USA.
Patients with rheumatoid arthritis are at increased risk of hematological malignancies, especially when exposed to immunosuppressive therapy. The mechanisms of lymphomagenesis remain poorly understood but factors implicated include high disease activity, exposure to antitumoral necrosis factor medications, and Epstein-Barr virus infection. Lymphoid malignancies of T-cell origin are uncommon in patients with rheumatoid arthirits. Read More
Case Rep Hematol 2018 1;2018:6819172. Epub 2018 Feb 1.
Southern Illinois University, Springfield, IL, USA.
Elliptocytosis is commonly seen as a hereditary condition. We present a case of myelodysplastic syndrome (MDS) del(q20) variant with concomitant acquired elliptocytosis. A 73-year-old male with a history of prostate cancer presented to the hospital for evaluation of bleeding gums. Read More
Case Rep Hematol 2017 21;2017:5758368. Epub 2017 Dec 21.
Department of Hematology and Oncology, Oji General Hospital, Tomakomai, Japan.
A 48-year-old man was diagnosed with multiple myeloma (IgG-k) and was treated with high-dose dexamethasone as an induction therapy followed by thalidomide-based regimens. Approximately 22 months after the initial diagnosis, the patient developed secondary plasma cell leukemia (PCL) with a white blood cell (WBC) count of 20.2 × 10/L including 79. Read More
Case Rep Hematol 2017 3;2017:1262368. Epub 2017 Dec 3.
Department of Pathology, N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, Kashirskoye shosse 24, Moscow 115478, Russia.
Richter's syndrome is the development of high-grade non-Hodgkin lymphoma (NHL) or Hodgkin lymphoma in patients with chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL). In most patients with Richter's syndrome, the high-grade NHL is diffuse large B-cell lymphoma. Only a small minority of CLL/SLL patients develop T-cell malignancies. Read More
Case Rep Hematol 2017 17;2017:3209305. Epub 2017 Dec 17.
Department of Hematology and Immunology, Otsu Red Cross Hospital, 1-1-35, Nagara, Otsu-shi, Shiga, Japan.
Myeloid blast crisis of chronic myeloid leukemia (CML-MBC) is rarely seen at presentation and has a poor prognosis. There is no standard therapy for CML-MBC. It is often difficult to distinguish CML-MBC from acute myeloid leukemia expressing the Philadelphia chromosome (Ph+ AML). Read More
Case Rep Hematol 2017 14;2017:3819457. Epub 2017 Dec 14.
Maimonides Medical Center, Brooklyn, NY, USA.
While splenic complications like hypersplenism, sequestration crisis, and infarction are commonly reported in sickle cell variants like sickle cell beta-plus thalassemia, splenic rupture with hematoma is rare. We present a case of a 32-year-old young male who presented with dull left upper quadrant pain who was found to have multiple subcapsular splenic lacerations and hematoma on abdominal imaging. Hemoglobin electrophoresis confirmed sickle cell beta-plus thalassemia in the patient. Read More
Case Rep Hematol 2017 20;2017:2861596. Epub 2017 Nov 20.
Department of Hematology, University Hospital of Ioannina, Ioannina, Greece.
Background: Plasmablastic lymphoma (PBL) is a rare, aggressive B-cell lymphoma with poor prognosis usually found in the oral cavity of HIV-positive patients. Chronic lymphocytic leukemia (CLL) is an indolent B-cell lymphoma with a variable clinical course. Transformation of CLL to PBL as Richter's syndrome is rare while coexistence of CLL and PBL at diagnosis is even rarer. Read More
Case Rep Hematol 2017 11;2017:3548936. Epub 2017 Dec 11.
Cancer Molecular Diagnostics, St. James's Hospital, Dublin 8, Ireland.
The introduction of the tyrosine kinase inhibitor (TKI) imatinib has revolutionised the outlook of chronic myeloid leukemia (CML); however, a significant proportion of patients develop resistance through several mechanisms, of which acquisition of kinase domain mutations is prevalent. In chronic-phase patients, these mutations become evident early in the disease course. A case is described of a chronic-phase CML patient who achieved a sustained, deep molecular response but who developed an Y253H kinase domain mutation nearly nine years after commencing imatinib. Read More
Case Rep Hematol 2017 31;2017:3732902. Epub 2017 Oct 31.
Division of Hematology, Takasago-seibu Hospital, Takasago 676-0812, Japan.
We report here two cases of Waldenstrom's macroglobulinemia (WM), one with central nervous system (CNS) symptoms and severe retinopathy and one with renal failure. In both cases, the serum IgM levels exceeded 3,000 mg/dL and monoclonal IgM-kappa was observed in the blood. At onset, Case 1, a 63-year-old female, developed CNS symptoms-namely, drowsiness and syncope. Read More
Case Rep Hematol 2017 30;2017:3862052. Epub 2017 Oct 30.
Division of Hematology and HSCT, Department of Oncology, King Abdulaziz Medical City, Riyadh, Saudi Arabia.
Erdheim-Chester disease (ECD) is a rare type of non-Langerhans cell histiocytosis, with only 550 cases reported worldwide. ECD is characterized by diffuse histiocytic infiltration of multiorgans. The age of presentation of this disease is typically between 40 and 70 years. Read More
Case Rep Hematol 2017 22;2017:5762525. Epub 2017 Oct 22.
Department of Haematology, Warwick Hospital, Warwick, UK.
Clinically significant cytomegalovirus (CMV) reactivation is not uncommon in patients with severe immunodeficiency secondary to underlying medical disorders or following aggressive immunosuppressive therapy. However, it is less frequently found in patients with low-grade haematological malignancies after nonintensive chemotherapy. We treated a patient at our centre for stage IVB follicular lymphoma with standard chemotherapy who successively developed CMV colitis associated with a CMV viral load of >3 million copies/ml. Read More
Case Rep Hematol 2017 15;2017:3724017. Epub 2017 Oct 15.
Department of Hematology, Laboratory of Cytometry, Hospital de Santo António, Centro Hospitalar do Porto, Rua D. Manuel II, s/n, 4099-001 Porto, Portugal.
Background: Aggressive natural killer cell leukemia (ANKL) is extremely rare and habitually manifests as a systemic disease with multiorgan failure that rapidly evolves to death. The neoplastic natural killer (NK) cells usually harbor the Epstein-Barr virus (EBV) with a latent viral infection pattern type II; they often have a cytoplasmic CD3 and surface CD3, CD2, and CD56 immunophenotype, and they show complex genetic abnormalities affecting multiple tumor suppressor genes and oncogenes. We present a rare case of CD56-negative ANKL and review the clinical and laboratorial criteria for the diagnosis, as well as the available therapies. Read More