544 results match your criteria Case reports in hematology[Journal]


Atypical Thrombotic Thrombocytopenic Purpura Presenting as Stroke.

Case Rep Hematol 2019 14;2019:7425320. Epub 2019 Jan 14.

Division of Hematology, Department of Internal Medicine, McGovern Medical School, The University of Texas Health Science Center at Houston, 6411 Fannin Street, Houston 77030, USA.

Here we report a case of atypical thrombotic thrombocytopenic purpura that presented as an ischemic cerebrovascular accident. A 56-year-old man with multiple cardiovascular risk factors presented with sudden left-sided weakness, slurred speech, and left facial droop. He showed mild improvement when he was treated with thrombolytic therapy according to the hospital stroke protocol. Read More

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http://dx.doi.org/10.1155/2019/7425320DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350572PMC
January 2019
1 Read

Autoimmune-Associated Hemophagocytosis and Myelofibrosis in a Newly Diagnosed Lupus Patient: Case Report and Literature Review.

Case Rep Hematol 2019 9;2019:3879148. Epub 2019 Jan 9.

Section of Hematology, Department of Medicine, UP-Philippine General Hospital, Manila, Philippines.

Bone marrow abnormalities in SLE are now becoming increasingly recognized, suggesting that the bone marrow may also be an important site of target organ damage. In this study, we present a rare case of concurrent autoimmune hemophagocytic syndrome and autoimmune myelofibrosis, potentially life-threatening conditions, in a newly diagnosed SLE patient. We report a case of a 30-year-old Filipino woman who presented with a one-year history of fever, constitutional symptoms, exertional dyspnea, joint pains, and alopecia and physical examination findings of fever, facial flushing, cervical lymphadenopathies, and knee joint effusions. Read More

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http://dx.doi.org/10.1155/2019/3879148DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343163PMC
January 2019
1 Read

Chronic Lymphocytic Leukemia Presenting as a Subcortical Watershed Infarct.

Case Rep Hematol 2019 9;2019:2089359. Epub 2019 Jan 9.

Internal Medicine, Monmouth Medical Center, Long Branch, New Jersey, USA.

Internal watershed infarcts (WI) involve white matter between deep and superficial arterial systems of middle cerebral artery. These infarcts are considered to be either from low blood flow or microembolism. Anemia is an extremely rare cause of watershed infarcts. Read More

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https://www.hindawi.com/journals/crihem/2019/2089359/
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http://dx.doi.org/10.1155/2019/2089359DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343168PMC
January 2019
3 Reads

False-Negative Platelet Factor 4 Antibodies and Serotonin Release Assay and the Utility of Repeat Testing in the Diagnosis of Heparin-Induced Thrombocytopenia and Thrombosis.

Case Rep Hematol 2019 8;2019:1585014. Epub 2019 Jan 8.

Department of Neurointensive Care, Cerebrovascular Center, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, Ohio 44195, USA.

Objective: To report a case of false-negative serological tests in the diagnosis of heparin-induced thrombocytopenia (HIT) followed by a brief review of the literature on this topic.

Case Presentation: A 75-year-old Caucasian female patient was admitted with a traumatic right ankle fracture that required open reduction and internal fixation. Despite postoperative subcutaneous heparin chemoprophylaxis, she developed deep vein thrombosis (DVT) and pulmonary embolism (PE) on day 4 and subsequently started on continuous heparin infusion. Read More

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http://dx.doi.org/10.1155/2019/1585014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341253PMC
January 2019
2 Reads

The Implications of Liver Biopsy Results in Patients with Myeloproliferative Neoplasms Being Treated with Ruxolitinib.

Case Rep Hematol 2019 6;2019:3294046. Epub 2019 Jan 6.

Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Ruxolitinib is increasingly being utilized for the treatment of myelofibrosis and polycythemia vera, but the potential for hepatic toxicity is poorly understood. We performed a retrospective review of hepatic damage occurring in patients with myeloproliferative neoplasms receiving ruxolitinib. Relevant histologic images of liver biopsies were reviewed by an experienced liver pathologist and reported to a multidisciplinary team including hepatology and hematology. Read More

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http://dx.doi.org/10.1155/2019/3294046DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339753PMC
January 2019
2 Reads

Durable Leukemic Remission and Autologous Marrow Recovery with Random Chromosomal Abnormalities after Allogeneic Hematopoietic Stem Cell Transplantation for Chronic Lymphocytic Leukemia.

Case Rep Hematol 2019 3;2019:9710790. Epub 2019 Jan 3.

Department of Hematology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.

A 38-year-old woman with aggressive clinical course of chronic lymphocytic leukemia (CLL) was treated with 8 courses of R-CHOP. Clinical remission was achieved, while B-cell clonality remained. Allogeneic hematopoietic stem cell transplantation was performed with reduced intensity conditioning (fludarabine and 2-Gy total body irradiation). Read More

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http://dx.doi.org/10.1155/2019/9710790DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6335663PMC
January 2019
3 Reads

Thrombotic Thrombocytopenic Purpura due to Checkpoint Inhibitors.

Case Rep Hematol 2018 20;2018:2464619. Epub 2018 Dec 20.

The T.W. Lewis Melanoma Center of Excellence, Banner MD Anderson Cancer Center, Gilbert, AZ, USA.

Ipilimumab is a monoclonal antibody that enhances the efficacy of the immune system by targeting a cytotoxic T-lymphocyte-associated protein 4 (CTLA-4), which is a protein receptor that downregulates the immune system. Nivolumab is also a humanized monoclonal antibody that targets another protein receptor that prevents activated T cells from attacking the cancer; this receptor is called programmed cell death 1 (PD-1). The FDA approved ipilimumab combined with nivolumab as a frontline therapy for patients with metastatic melanoma or renal cell carcinoma and as a second-line therapy for patients with microsatellite instability-high (MSI-H) metastatic colon cancer. Read More

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http://dx.doi.org/10.1155/2018/2464619DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317083PMC
December 2018
2 Reads

The Use of Natural Health Products Especially Papaya Leaf Extract and Dandelion Root Extract in Previously Untreated Chronic Myelomonocytic Leukemia.

Case Rep Hematol 2018 18;2018:7267920. Epub 2018 Dec 18.

Department of Hematologic Malignancies and Blood and Marrow Transplant, University of California, San Francisco, CA, USA.

Chronic myelomonocytic leukemia (CMML) is a clonal hematopoietic disorder which shares clinical and morphological features of myelodysplastic syndrome and myeloproliferative neoplasms. Conventional therapeutic options include hydroxyurea, hypomethylating agents, and systemic chemotherapy, which are all palliative measures and are associated with potential side effects. Allogeneic hematopoietic cell transplantation is the only curative option. Read More

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http://dx.doi.org/10.1155/2018/7267920DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6312608PMC
December 2018
2 Reads

An Unusual Coexistence of Primary Central Nervous System Non-Hodgkin's Lymphoma and Acute Promyelocytic Leukemia.

Case Rep Hematol 2018 19;2018:2741939. Epub 2018 Dec 19.

Nicola Stefano Fracchiolla, Mariarita Sciumè, Agostino Cortelezzi, Hematology Unit, Fondazione IRCCS Ca'Granda Ospedale Maggiore Policlinico, Via Francesco Sforza, 35, 20122 Milan, Italy.

Acute promyelocytic leukemia and primary central nervous system lymphoma are uncommon hematological malignancies. The co-occurrence of acute myeloid leukemia with various lymphoproliferative diseases is an extremely rare condition, especially in the absence of previous chemotherapy or radiotherapy. Herein, we provide a comprehensive characterization of a patient with concomitant diagnosis of extranodal high-grade non-Hodgkin B-cell neoplasm confined to the central nervous system and acute promyelocytic leukemia. Read More

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http://dx.doi.org/10.1155/2018/2741939DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6313991PMC
December 2018
2 Reads

Cyclin-Dependent Kinase 4/6 Inhibitor (Palbociclib) Induced Aplastic Anemia in a Patient with Metastatic Breast Cancer.

Case Rep Hematol 2018 13;2018:9249506. Epub 2018 Dec 13.

Section of Hematology and Medical Oncology, Department of Medicine, Boston Medical Center, Boston, Massachusetts, USA.

Breast cancer is the most common cancer diagnosed in women worldwide. Over the years, breast cancer treatment has undergone revolutionary changes especially for women with hormone receptor positive metastatic disease. As a result, women are living longer with their disease, particularly in developed countries. Read More

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https://www.hindawi.com/journals/crihem/2018/9249506/
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http://dx.doi.org/10.1155/2018/9249506DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311830PMC
December 2018
5 Reads

A Rare Case of Triple-Negative Essential Thrombocythemia in a Young Postsplenectomy Patient: A Diagnostic Challenge.

Case Rep Hematol 2018 16;2018:9079462. Epub 2018 Dec 16.

Division of Hematology, University of Texas Health Science Center at Houston, Houston, TX, USA.

The distinction between primary and reactive thrombocytosis by bone marrow histology is very important. Reactive thrombocytosis, the most common cause of thrombocytosis, can be expected in postsplenectomy states; however, close hematological evaluation of prolonged thrombocytosis is essential to identify patients who may have an underlying myeloproliferative neoplasm. We report a 37-year-old woman who was found to have portal, mesenteric, and splenic vein thrombosis with thrombocytosis, two months after she had a splenectomy for spontaneous splenic rupture. Read More

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http://dx.doi.org/10.1155/2018/9079462DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311807PMC
December 2018
2 Reads

Dysphagia as an Unusual Presentation of Myeloma.

Case Rep Hematol 2018 13;2018:6910624. Epub 2018 Dec 13.

Otorhinolaryngology Department, Avicenna Military Hospital, Marrakech, Morocco.

Multiple myeloma is a plasma cell dyscrasis characterized by mature B cells proliferation in the bone marrow. In rare cases, the disease can present as an extramedullary location, making diagnosis and management more challenging. Here, we describe a rare case of tongue extramedullary myeloma and discuss diagnostic, prognostic, and therapeutic issues. Read More

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http://dx.doi.org/10.1155/2018/6910624DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311888PMC
December 2018
3 Reads

A Case of Myeloproliferative Neoplasm with BCR-FGFR1 Rearrangement: Favorable Outcome after Haploidentical Allogeneic Transplantation.

Case Rep Hematol 2018 6;2018:5724960. Epub 2018 Dec 6.

Cytogenetic Unit, Hospital Universitario de La Princesa, Madrid, Spain.

Hematopoietic myeloproliferative neoplasms with FGFR1 rearrangement result in the 8p11 myeloproliferative syndrome that in the current Word Health Organization classification is designated as "myeloid and lymphoid neoplasm with FGFR1 abnormalities." We report the case of a 66-year-old man who had clinical features that resembled chronic myeloid leukaemia (CML), but bone marrow cytogenetic and fluorescent in situ hybridization (FISH) studies showed t(8;22)(p11;q11) and BCR-FGFR1 fusion gene. He was initially managed with hydroxyurea, and given the aggressive nature of this disease, four months later, the patient underwent an allogeneic hematopoietic stem-cell transplantation (HSCT) from an HLA-haploidentical relative. Read More

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http://dx.doi.org/10.1155/2018/5724960DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311782PMC
December 2018
2 Reads

Obstructive Jaundice due to Pancreatic Involvement as an Initial Presentation of Adult Acute Lymphoblastic Leukemia.

Case Rep Hematol 2018 4;2018:9175360. Epub 2018 Dec 4.

Leighton Hospital NHS Trust, Crewe, Cheshire, UK.

Acute lymphoblastic leukemia (ALL) is a heterogeneous group of lymphoid disorders characterized by monoclonal proliferation and expansion of immature lymphoid cells in the bone marrow, blood, and other organs. It commonly presents with nonspecific symptoms such as lethargy, easy bruising, and weight loss. In this article, we present the case of a 48-year-old male who presented to the hospital with painless jaundice resulting from pancreatic infiltration, initially thought to be due to pancreatic or hepatobiliary malignancy. Read More

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http://dx.doi.org/10.1155/2018/9175360DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304853PMC
December 2018
1 Read

Blastoid Variant Mantle Cell Lymphoma Expressing Aberrant CD3 and CD10 with Concurrent Small Lymphocytic Lymphoma: Establishment of a Clonal Relationship by B- and T-Cell Receptor Gene Rearrangements.

Case Rep Hematol 2018 5;2018:8303571. Epub 2018 Dec 5.

Medical Oncology and Hematology, 7777 Milliken Avenue Suite 210, Rancho Cucamonga, CA 91730, USA.

Mantle cell lymphoma (MCL) is an aggressive non-Hodgkin B-cell lymphoma typically expressing CD19, CD20, CD5, FMC-7, CyclinD1, and SOX-11 and harboring the IgH/CCND1 translocation. We report a blastoid variant of mantle cell lymphoma (MCL) involving an inguinal lymph node that, in addition to classical phenotypic and genetic findings, also aberrantly coexpresses surface CD10 and cytoplasmic CD3. Small lymphocytic lymphoma (SLL) was also present in the same lymph node and in the bone marrow. Read More

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http://dx.doi.org/10.1155/2018/8303571DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6305046PMC
December 2018
4 Reads

Efficacy of Carfilzomib, Lenalidomide, and Dexamethasone for Extramedullary Intracranial Localization of Multiple Myeloma.

Case Rep Hematol 2018 29;2018:2312430. Epub 2018 Nov 29.

Department of Haematology and BMT Unit, Antonio Perrino Hospital, Brindisi, Italy.

EMD of myeloma usually occurs several years after diagnosis and is associated with a very poor OS of <6 months due to the fact that there are no efficient treatment options. In rrMM with EMDs, the most effective treatment is a lymphoma-like polychemotherapy regimen such as PACE, Dexa-BEAM, and HyperCVAD followed by ASCT or allogeneic SCT. RT of soft-tissue plasmacytoma is the further treatment choice and results in a high rate of local control and a prolonged disease-free survival. Read More

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http://dx.doi.org/10.1155/2018/2312430DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304832PMC
November 2018
5 Reads

Philadelphia Translocation in MDS: A Case Report and a Brief Review of the Literature Looking at Its Prevalence, Disease Progression, and Treatment Options.

Case Rep Hematol 2018 22;2018:5865321. Epub 2018 Nov 22.

SSM Health St. Mary's Hospital, St. Louis, Missouri 63117, USA.

Myelodysplastic syndrome (MDS) is a group of clonal disorders characterized by ineffective and dysplastic hematopoiesis in the bone marrow with variable risk of progression to leukemia. MDS is characterized by specific karyotypic and molecular abnormalities. The t(9 : 22) Philadelphia translocation is not a common abnormality found in MDS, and it is not included in the prognostic indices for germline mutations. Read More

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http://dx.doi.org/10.1155/2018/5865321DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6282134PMC
November 2018
1 Read

Rare Coexistence of Acute Monoblastic Leukemia with Chronic Lymphocytic Leukemia.

Case Rep Hematol 2018 6;2018:6452843. Epub 2018 Nov 6.

Associate Consultant, Department of Hematooncology, Artemis Hospitals, Gurgaon, India.

Acute monoblastic leukemia (AMoL) is a rare hematopoietic neoplasm, and simultaneous occurrence of acute monoblastic leukemia with chronic lymphocytic leukemia is very rare and only a few cases have been reported in the literature. We here report a rare case of dual hematological malignancy in an 85-year-old male. The peripheral blood and bone marrow examination revealed dual population of atypical cells, comprising large cells with opened-up chromatin having monocytic appearance and small mature-appearing lymphocytes. Read More

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https://www.hindawi.com/journals/crihem/2018/6452843/
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http://dx.doi.org/10.1155/2018/6452843DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6247670PMC
November 2018
7 Reads

Is There a Role for Biweekly Romiplostim in the Management of Chronic Immune Thrombocytopenia (ITP)? A Report of Three Cases.

Case Rep Hematol 2018 24;2018:6037494. Epub 2018 Oct 24.

Division of Hematology, Department of Medicine, The Ottawa Hospital, Ottawa, Ontario, Canada.

Romiplostim is a peptibody, which stimulates platelet production by a mechanism similar to that of endogenous thrombopoietin. It has an established indication as second-line therapy in patients with chronic immune thrombocytopenia (ITP). The agent is typically administered weekly; however, there are instances where a biweekly (i. Read More

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https://www.hindawi.com/journals/crihem/2018/6037494/
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http://dx.doi.org/10.1155/2018/6037494DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6247720PMC
October 2018
6 Reads

Plasmablastic Lymphoma in an Immunocompetent Patient with MDS/MPN with Ring Sideroblasts and Thrombocytosis-A Case Report.

Case Rep Hematol 2018 4;2018:2525070. Epub 2018 Nov 4.

Second Department of Internal Medicine and Research Unit, University General Hospital "Attikon", 1 Rimini St., Haidari, 12462 Athens, Greece.

Plasmablastic lymphoma (PBL) is a rare, aggressive type of B-cell non-Hodgkin lymphoma with the vast majority of patients responding poorly to treatment or progressing shortly thereafter. Cyclophosphamide-doxorubicin-vincristine-prednisolone (CHOP) or CHOP-like regimens have disappointing results in this setting. We report a case of PBL arising in a previously diagnosed myelodysplastic/myeloproliferative (MDS/MPN) with ring sideroblasts and thrombocytopenia (RS-T), HIV-negative patient treated with the combination of CHOP and bortezomib. Read More

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http://dx.doi.org/10.1155/2018/2525070DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6247723PMC
November 2018
2 Reads

Paroxysmal Cold Hemoglobinuria in an Adult with Respiratory Syncytial Virus.

Case Rep Hematol 2018 13;2018:7586719. Epub 2018 Nov 13.

Division of Hematology and Medical Oncology, Department of Medicine, Mount Sinai Beth Israel, Mount Sinai Hospital, New York, NY, USA.

Paroxysmal cold hemoglobinuria (PCH) is a rare form of cold autoimmune hemolytic anemia first discovered in the early 20th century in adults with tertiary syphilis. Today, it is more commonly seen in children as a life-threatening anemia during a viral upper respiratory tract infection (URI). Although respiratory syncytial virus (RSV) has previously been reported to cause PCH in a child, herein we present the first documented case in an adult. Read More

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http://dx.doi.org/10.1155/2018/7586719DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6257899PMC
November 2018
6 Reads

Management of Acquired Hemophilia A in Elderly Patients.

Case Rep Hematol 2018 13;2018:6757345. Epub 2018 Nov 13.

Division of Hematology, Takasago-Seibu Hospital, Takasago 676-0812, Japan.

This report describes six elderly patients with acquired hemophilia A (AHA), including four individuals aged ≥90 years. Bleeding symptoms were subcutaneous or intramuscular hemorrhage (=4), hematuria (=1), and hemorrhagic shock after tooth extraction (=1). Factor VIII (FVIII) activity ranged from <1. Read More

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http://dx.doi.org/10.1155/2018/6757345DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6260550PMC
November 2018
1 Read

Transitory Spontaneous Remission of Myelodysplasia in an Elderly Man while Receiving Intravesical Bacillus Calmette-Guérin for Bladder Cancer: A Case Report and Review of the Literature.

Case Rep Hematol 2018 11;2018:9750532. Epub 2018 Nov 11.

Physician, General Medicine, Hospital de Carabineros de Chile, Simón Bolívar 2200, Ñuñoa 7770199, Santiago, Chile.

Myelodysplasia is a clonal disorder characterized by progressive cytopenias. Intravescial BCG is standard immunotherapy for superficial bladder cancer. We present a patient with transfusion-dependent myelodysplasia whose blood counts normalized during treatment with intravesical BCG for bladder cancer. Read More

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http://dx.doi.org/10.1155/2018/9750532DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6252232PMC
November 2018
2 Reads

Composite Lymphoma Comprising Extranodal NK/T-Cell Lymphoma and Diffuse Large B-Cell Lymphoma.

Case Rep Hematol 2018 31;2018:1583925. Epub 2018 Oct 31.

Department of Hematology, Toyota Kosei Hospital, Toyota, Japan.

We report a rare case of composite lymphoma comprising extranodal NK/T-cell lymphoma, nasal type, (ENKL) and diffuse large B-cell lymphoma (DLBCL) in a 70-year-old man complaining of fatigue. Computed tomography showed multiple consolidations in both lungs, and ENKL was diagnosed from transbronchial lung biopsy. Positron emission tomography also detected abnormal uptake in the stomach, and DLBCL was diagnosed from subsequent gastroscopy. Read More

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http://dx.doi.org/10.1155/2018/1583925DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6234446PMC
October 2018
2 Reads

Pompe Disease Could Mimic Exam Findings of Amyloidosis: Two Rare Diagnoses Bona Fide.

Case Rep Hematol 2018 28;2018:9615834. Epub 2018 Oct 28.

Department of Internal Medicine, Mayo Clinic, Rochester, MN, USA.

A 70-year-old female presented with a three-year history of evolving macroglossia causing dysphagia and dysarthria, with proximal muscle weakness. Given the classic physical finding of macroglossia, the patient underwent extensive evaluation for amyloidosis which proved to be negative apart from a bone marrow biopsy which stained positive for transthyretin without amino acid sequence abnormality, thus giving wild-type transthyretin amyloidosis. Since the wild-type transthyretin amyloidosis could not entirely explain her clinical presentation and evaluation, further studies were conducted in a sequential manner, thus leading to a diagnosis of Pompe disease explaining her presenting signs and symptoms including her macroglossia. Read More

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http://dx.doi.org/10.1155/2018/9615834DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6230410PMC
October 2018
2 Reads

A Case of Posttransfusion Purpura with Severe Refractory Thrombocytopenia but No Cutaneous Manifestations.

Case Rep Hematol 2018 29;2018:8187659. Epub 2018 Oct 29.

Department of Immunology and Transfusion Medicine, Oslo University Hospital, Oslo, Norway.

Posttransfusion purpura is a serious adverse effect of transfusion due to HPA-antibodies. A young female was diagnosed with acute leukaemia, and treatment commenced. Severe thrombocytopenia ensued. Read More

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http://dx.doi.org/10.1155/2018/8187659DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6231382PMC
October 2018
2 Reads

Erratum to "A Case of Bing-Neel Syndrome Successfully Treated with Ibrutinib".

Case Rep Hematol 2018 29;2018:7610201. Epub 2018 Oct 29.

Center for Lymphoid Malignancies, Columbia University Medical Center, College of Physicians and Surgeons, New York, NY, USA.

[This corrects the article DOI: 10.1155/2018/8573105.]. Read More

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http://dx.doi.org/10.1155/2018/7610201DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6231375PMC
October 2018
1 Read

Solitary Lytic Bone Metastasis: A Rare Presentation of Small Lymphocytic Leukemia.

Case Rep Hematol 2018 30;2018:6154709. Epub 2018 Oct 30.

Department of Hematology/Oncology, Joan C. Edwards School of Medicine Marshall University, 1600 Medical Center Dr, Huntington, WV 25701, USA.

Chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL) is a hematologic malignancy characterized by an over accumulation of incompetent neoplastic lymphocytes. Bone metastasis in CLL/SLL is very rare. We report a case of a 76-year-old Caucasian female presented with an unresolving pulmonary infiltrate with mediastinal lymphadenopathy concerning for malignancy. Read More

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http://dx.doi.org/10.1155/2018/6154709DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6232806PMC
October 2018
4 Reads

Progressive Intramuscular Haematoma in a 12-Year-Old Boy: A Case of Acquired Haemophilia A.

Case Rep Hematol 2018 24;2018:6208597. Epub 2018 Oct 24.

Senior Registrar, Department of Pathology, Faculty of Medical Sciences, University of Sri Jayewardenepura, Nugegoda, Sri Lanka.

Acquired hemophilia A (AHA) is a rare bleeding disorder due to acquired antibodies against coagulation factor VIII (FVIII). It is rare in children less than 16 years old, and the incidence is 0.45/million/year. Read More

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https://www.hindawi.com/journals/crihem/2018/6208597/
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http://dx.doi.org/10.1155/2018/6208597DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6220402PMC
October 2018
10 Reads

Drug-Induced Hypersensitivity Syndrome: A Clinical, Radiologic, and Histologic Mimic of Lymphoma.

Case Rep Hematol 2018 21;2018:7037352. Epub 2018 Oct 21.

Department of Pathology, The University of Oklahoma Health Sciences Center, 940 Stanton L. Young Boulevard, BMSB 451, Oklahoma City, OK 73104, USA.

Drug-induced hypersensitivity syndrome (DIHS; also known as drug reaction with eosinophilia and systemic symptoms, or DRESS) is a rare, potentially life-threatening condition that typically presents 2-8 weeks after drug exposure with fever, rash, organ dysfunction, and lymphadenopathy. Here, we describe the case of an 18-year-old African American female who presented with cervical lymphadenopathy, fevers, and a macular rash. A PET scan showed diffuse hypermetabolic lymphadenopathy suggestive of lymphoma, with involvement of the spleen and kidneys. Read More

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http://dx.doi.org/10.1155/2018/7037352DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6215581PMC
October 2018
2 Reads

Suspected Pericardial Tuberculosis Revealed as an Amyloid Pericardial Mass.

Case Rep Hematol 2018 17;2018:8606430. Epub 2018 Oct 17.

Department of Biomedical Sciences and Human Oncology, Section of Internal Medicine "G. Baccelli", University of Bari Aldo Moro Medical School, Bari, Italy.

Primary systemic amyloidosis is not easily diagnosed. The immunoglobulin deposits are usually localized in the kidney, heart, and liver. We describe an unusual case of a patient suffering from a pericardial amyloidoma with internal calcifications and air bubbles that compressed the right ventricle and shifted the heart to the left. Read More

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https://www.hindawi.com/journals/crihem/2018/8606430/
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http://dx.doi.org/10.1155/2018/8606430DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6207883PMC
October 2018
18 Reads

De Novo Psoriasis Vulgaris Diagnosed after Nivolumab Treatment for Refractory Hodgkin's Lymphoma, Completely Resolved after Autologous Hematopoietic Stem Cell Transplantation.

Case Rep Hematol 2018 16;2018:6215958. Epub 2018 Oct 16.

Adults Hematology and Stem Cell Transplantation Department, King Fahad Specialist Hospital, Dammam, Saudi Arabia.

The programmed cell death protein-1 (PD-1) inhibitor nivolumab has been recently approved as an effective and safe treatment for patients with refractory/relapsed Hodgkin's lymphomas. Dermatological adverse events, mainly skin rash, have been reported in 1-5% of patients. We describe a case of de novo psoriasis vulgaris (PsV), diagnosed after nivolumab treatment for refractory Hodgkin's lymphoma. Read More

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http://dx.doi.org/10.1155/2018/6215958DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6206568PMC
October 2018
19 Reads

An Unprecedented Case of p190 Chronic Myeloid Leukemia Diagnosed during Treatment for Multiple Myeloma: A Case Report and Review of the Literature.

Case Rep Hematol 2018 10;2018:7863943. Epub 2018 Oct 10.

Department of Hematology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.

We report the case of a 76-year-old man who was diagnosed as having chronic myeloid leukemia (CML) with p190 while receiving treatment for symptomatic multiple myeloma (MM). The diagnosis of MM was based on the presence of serum M-protein, abnormal plasma cells in the bone marrow, and lytic bone lesions. The patient achieved a partial response to lenalidomide and dexamethasone treatment. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6199862PMC
October 2018
26 Reads

West Nile Encephalitis, an Unusual Infection in a Chronic Lymphocytic Leukemia Patient.

Case Rep Hematol 2018 14;2018:3270348. Epub 2018 Oct 14.

Department of Hematology-Oncology, South Texas VA, 7400 Merton Minter, San Antonio, TX 78229, USA.

CNS involvement by CLL is a rare occurrence, usually happening in the context of a transformation to a more aggressive lymphoma in what is known as Richter's transformation. We report a patient with active CLL who developed confusion and was found to have West Nile encephalitis that initially mimicked CNS involvement by CLL. The patient recovered with supportive treatment and later restarted ibrutinib therapy. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6204171PMC
October 2018
10 Reads

Pure Red Cell Aplasia Associated with Thymolipoma: Complete Anaemia Resolution following Thymectomy.

Case Rep Hematol 2018 9;2018:8627145. Epub 2018 Oct 9.

Haematology Department, Haematology Staff Specialist, John Hunter Hospital, Lookout Rd., New Lambton Heights, NSW 2305, Australia.

Pure red cell aplasia is an uncommon cause of anaemia rarely associated with thymoma. A combination of immunosuppressive therapy and thymectomy offers a potential cure. Thymectomy alone rarely results in anaemia resolution. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6198544PMC
October 2018
2 Reads

Pulmonary Intravascular B-Cell Lymphoma with Angiotropism/Angioinvasion Mimicking Interstitial Lung Disease: A Clinical Dilemma and Potential Diagnostic Challenge.

Case Rep Hematol 2018 8;2018:3821392. Epub 2018 Oct 8.

Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada.

Intravascular large B cell lymphoma (IVLBCL) is a rare type of extranodal diffuse large B-cell lymphoma. Patients typically present with nonspecific findings, particularly bizarre neurologic symptoms, fever, and skin lesions. IVLBCL with primary lung presentation is very rare and difficult to diagnose. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6196920PMC
October 2018
13 Reads

Splenic B-Cell Lymphomas with Diffuse Cyclin D1 Protein Expression and Increased Prolymphocytic Cells: A Previously Unrecognized Diagnostic Pitfall.

Case Rep Hematol 2018 27;2018:5761953. Epub 2018 Sep 27.

Department of Pathology, Division of Hematopathology, University of Miami, Sylvester Comprehensive Cancer Center and Jackson Memorial Hospital, Miami, Florida, USA.

Prolymphocytic transformation is a concept usually applied in the context of chronic lymphocytic leukemia/small lymphocytic lymphoma to describe the presence of a high percentage of prolymphocytes in peripheral blood (usually more than 55%). Prolymphocytic transformation has also been reported in mantle cell lymphoma (MCL) but only rarely in splenic marginal zone lymphoma (SMZL). We present two splenic B-cell lymphomas presenting in the leukemic phase and with increased prolymphocytes, both classified as SMZL with prolymphocytic transformation. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6180998PMC
September 2018
3 Reads

A Giant Right Heart Thrombus-in-Transit: The Challenge of Anticoagulation in Factor V Leiden Thrombophilia.

Case Rep Hematol 2018 27;2018:9098604. Epub 2018 Sep 27.

Internal Medicine Residency Department, Aventura Hospital and Medical Center, 20900 Biscayne Boulevard, Aventura, FL 33190, USA.

Factor V Leiden (FVL) is an autosomal dominant condition resulting in thrombophilia. Factor V normally acts as a cofactor for prothrombinase, helping cleave prothrombin to thrombin. A single point mutation in it disrupts factor V, making it unreceptive to protein C and increasing the risk of thrombosis. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6180927PMC
September 2018
13 Reads

Sarcoidosis and Monoclonal Gammopathy of Undetermined Significance (MGUS): A True Association or Just a Coincidence?

Case Rep Hematol 2018 25;2018:3790760. Epub 2018 Sep 25.

Michigan State University, Clinical Center, 788 Service Road, East Lansing, MI 48824, USA.

Sarcoidosis is a systemic inflammatory disease characterized by the presence of noncaseating granulomas in different organs. Sarcoidosis associated with monoclonal gammopathy of undetermined significance (MGUS) is a rare finding with only 10 cases reported to date. We describe a 79-year-old male patient who presented with dry mouth for 4 months. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6176294PMC
September 2018
6 Reads

Classical Hodgkin Lymphoma Presenting with Severe, Recurrent Hypothermic Episodes.

Case Rep Hematol 2018 25;2018:3726593. Epub 2018 Sep 25.

Department of Hematology, Aarhus University Hospital, Tage-Hansens Gade 2, DK-8000 Aarhus, Denmark.

We report a case presenting with recurrent episodes of severe hypothermia preceding the diagnosis of Hodgkin lymphoma. The episodes of hypothermia were accompanied by other symptoms of autonomic dysfunction, mainly hypotension, which could be caused by autonomic neuropathy as part of a paraneoplastic syndrome. In comparison with previous reports describing an association between the presence of hypothermia and an adverse outcome, the present patient has responded well to lymphoma-specific treatment and is currently in an ongoing complete remission. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6176302PMC
September 2018
20 Reads

Multiple Myeloma Masquerading as Ovarian Carcinosarcoma Metastases: A Case Report and Review of the Approach to Multiple Myeloma Screening and Diagnosis.

Case Rep Hematol 2018 24;2018:3029650. Epub 2018 Sep 24.

Dana Farber Cancer Institute, 450 Brookline Avenue, Boston, MA 02215, USA.

Multiple myeloma is the most common plasma cell dyscrasia and causes 2% of all cancer deaths in Western countries. Ovarian carcinosarcomas are very rare gynecological malignancies and account for only 1-2% of all ovarian tumors. In this case, we report a 67-year-old woman with known relapsed ovarian carcinosarcoma who presented with headache and neck pain. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6174775PMC
September 2018
12 Reads

Chronic Myeloid Leukemia Relapsing 25 Years after Allogenic Stem Cell Transplantation.

Case Rep Hematol 2018 23;2018:2045985. Epub 2018 Sep 23.

Section for Hematology, Institute of Clinical Science, University of Bergen, Bergen, Norway.

Chronic myeloid leukemia (CML) is a myeloproliferative disorder in which neoplastic cells exhibit the Philadelphia chromosome and the related oncoprotein . Allogeneic stem cell transplantation (allo-SCT) was considered the first-line treatment for CML, before the introduction of tyrosine kinase inhibitors (TKIs). However, patients are at risk for relapse years after transplantation. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6174736PMC
September 2018
3 Reads

Successful Antimicrobial Treatment of Phlegmonous Gastritis: A Case Report and Literature Review.

Case Rep Hematol 2018 16;2018:8274732. Epub 2018 Sep 16.

Department of Hematology and Oncology, Mayo Clinic, Jacksonville, FL, USA.

Phlegmonous gastritis is an uncommon acute bacterial infection of the stomach that carries a fatal prognosis in spite of the advent of antibiotics. A high index of suspicion is required in patients with risk factors. An immunocompromised state is identified as one of the most important risk factors. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6164362PMC
September 2018
4 Reads

Simultaneous Occurrence of Rosai-Dorfman Disease and Nodal Marginal Zone Lymphoma in a Patient with Sjögren's Syndrome.

Case Rep Hematol 2018 16;2018:7930823. Epub 2018 Sep 16.

Department of Therapeutic Dentistry, I.M. Sechenov First Moscow State Medical University, Trubetskaya, 8, Building 2, Moscow 119991, Russia.

We present an exceptionally rare case of co-occurrence of Rosai-Dorfman disease (RDD) and nodal marginal zone lymphoma (NMZL) in a 60-year-old Caucasian female with a 20-year course of Sjögren's syndrome (SS). In response to treatment for lymphoma, the patient presented a short positive response, followed by a rapid progression of the disease accompanied by the development of the peripheral facial nerve palsy. We failed to detect Epstein-Barr virus (EBV) in the NMZL/RDD sample by EBV-encoded RNA (EBER) in situ hybridization but identified genomic DNA of EBV by polymerase chain reaction. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6165590PMC
September 2018
3 Reads

Myeloid Sarcoma of Orbits: Effectiveness of a Low-Dose Radiation Regimen.

Case Rep Hematol 2018 9;2018:9071693. Epub 2018 Sep 9.

Division of Hematology and Oncology, Newark Beth Israel Medical Center, Newark, NJ, USA.

Acute myeloid leukemia (AML) can present with extramedullary involvement known as myeloid sarcoma (MS). We present the case of a young woman who was diagnosed with AML and MS in bilateral orbits, brain, omentum, and retroperitoneum. She was treated with induction chemotherapy. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6151198PMC
September 2018
5 Reads

Improvement of Cardiac Vegetations in Antiphospholipid Syndrome with Enoxaparin and Corticosteroids after Rivaroxaban Failure.

Case Rep Hematol 2018 9;2018:8097539. Epub 2018 Sep 9.

Scripps Mercy Hospital, Department of Cardiology, San Diego, CA, USA.

Cardiac disease is a well-known complication of antiphospholipid syndrome (APS), with many patients presenting with valvular thickening or vegetations, referred to as Libman-Sacks endocarditis (LSE). Because cases of APS with cardiac involvement are relatively rare, paucity of large clinical trials studying this complication has made management challenging. In the absence of acute heart failure and embolic events, a medical approach is usually selected, consisting of anticoagulation and possibly corticosteroids when another underlying autoimmune disease is present. Read More

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http://dx.doi.org/10.1155/2018/8097539DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6151239PMC
September 2018
5 Reads

Concurrent Diagnosis of Chronic Myeloid Leukemia and Follicular Lymphoma: An Unreported Presentation.

Case Rep Hematol 2018 9;2018:7493601. Epub 2018 Sep 9.

Lombardi Comprehensive Cancer Center, Department of Hematology and Oncology, MedStar Georgetown University Hospital, 3800 Reservoir Rd. NW, Washington, DC 20007, USA.

Lymphadenopathy in chronic myeloid leukemia (CML) is usually due to extramedullary involvement with accelerated or blast phases of the disease. The occurrence of non-Hodgkin lymphoma (NHL) as a synchronous malignancy with CML is rare. We report a case of a 73-year-old male who presented with dyspnea and right-sided lower extremity edema in the setting of leukocytosis. Read More

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http://dx.doi.org/10.1155/2018/7493601DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6151199PMC
September 2018
4 Reads

Management of Thrombosis Risk in a Carrier of Hemophilia A with Low Factor VIII Levels with Atrial Fibrillation: A Clinical Case and Literature Review.

Case Rep Hematol 2018 5;2018:2615838. Epub 2018 Sep 5.

Dept of Medicine, Hospital de Carabineros, Simon Boliovar 2200, Nuñoa, 7770199 Santiago de, Chile.

Nonvalvular atrial fibrillation (AF) is a common age-related arrthymia and a leading cause of stroke in the elderly; with an aging hemophilia population, the number of patients developing AF is increasing. There are no controlled trials on thromboprophylaxis in this group of patients, only consensus opinion was based on small case reports. We present a female patient, carrier for hemophilia and with clinically moderately severe hemophilia who developed FA. Read More

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http://dx.doi.org/10.1155/2018/2615838DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6145163PMC
September 2018
18 Reads

A Case of Bing-Neel Syndrome Successfully Treated with Ibrutinib.

Case Rep Hematol 2018 28;2018:8573105. Epub 2018 Aug 28.

Center for Lymphoid Malignancies, Columbia University Medical Center-College of Physicians and Surgeons, New York, NY, USA.

Bing-Neel syndrome is a rare manifestation of Waldenström macroglobulinemia characterized by lymphoplasmacytic cells' infiltration into the central nervous system. We present a case of a 74-year-old patient with a known diagnosis of Waldenström macroglobulinemia and newly depressed consciousness. Flow cytology of his cerebral spinal fluid demonstrated a lambda light chain-restricted population of B-cells consistent with a CD5+ CD10+ B-cell lymphoma. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6136466PMC
August 2018
6 Reads

Anti-CD20 Treatment of Autoimmune Hemolytic Anemia Refractory to Corticosteroids and Azathioprine: A Pediatric Case Report and Mini Review.

Case Rep Hematol 2018 26;2018:8471073. Epub 2018 Aug 26.

Department of Pediatrics, University Hospital of Ioannina, Ioannina, Greece.

Autoimmune hemolytic anemia (AIHA) is a relatively uncommon hematological entity in children and sometimes is characterized by a severe course requiring more than one line course therapy. Treatment decisions depend on the severity and chronicity of the anemia and the characteristics of the autoantibodies. Immunosuppression with corticosteroids is the first-line treatment, especially in warm-reactive AIHA. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6129358PMC
August 2018
4 Reads