563 results match your criteria Case reports in hematology[Journal]


A Rare Cause of Thrombotic Thrombocytopenia Purpura- (TTP-) Like Syndrome, Vitamin B12 Deficiency: Interpretation of Significant Pathological Findings.

Case Rep Hematol 2019 18;2019:1529306. Epub 2019 Mar 18.

Department of Hematology-Oncology, University of Arizona Cancer Center, Tucson, AZ, USA.

Thrombotic thrombocytopenia purpura (TTP) is a hematological emergency that requires rapid assessment followed by prompt initiation of therapy due to high mortality associated with delayed treatment. TTP has many causes including heritable syndromes, ADAMTS13 deficiency, and drugs-related etiologies. Profound vitamin B12 deficiency can, in rare cases, mimic TTP in presentation, and since plasmapheresis can be of limited benefit, prompt diagnosis is necessary for accurate treatment with B12. Read More

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http://dx.doi.org/10.1155/2019/1529306DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442445PMC

Central Nervous System Involvement by Waldenstrom Macroglobulinemia: A Case Report of the Bing-Neel Syndrome.

Case Rep Hematol 2019 14;2019:4075960. Epub 2019 Mar 14.

VA Pittsburgh Healthcare System, Division of Hematology/Oncology, University Drive C, 8th Floor, Pittsburgh, PA 15240, USA.

Bing-Neel syndrome (BNS) is a rare complication of Waldenstrom macroglobulinemia (WM) defined by a lymphoplasmacytic infiltration of the central nervous system (CNS). Patients present with a range of neurologic symptoms of variable severity. Diagnosis requires a low threshold of suspicion and is considered in WM patients with unexplained neurologic symptoms. Read More

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http://dx.doi.org/10.1155/2019/4075960DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437752PMC

Entecavir-Associated Thrombocytopenia: A Case Report and Review of the Pathophysiology, Diagnosis, and Treatment of a Rare but Reversible Cause of Thrombocytopenia.

Case Rep Hematol 2019 12;2019:4319148. Epub 2019 Mar 12.

Department of Internal Medicine, Texas Health Presbyterian Hospital, Dallas, Texas 75231, USA.

Drug-associated thrombocytopenia is often unrecognized. We report a 76-year-old female with lymphoma who presented with easy bruising and oral bleeding. She had undergone screening for hepatitis B virus (HBV) prior to starting rituximab and was found to have hepatitis B core serum antibody (IgG anti-HBc). Read More

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https://www.hindawi.com/journals/crihem/2019/4319148/
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http://dx.doi.org/10.1155/2019/4319148DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434310PMC
March 2019
1 Read

Bone Marrow Aspirate Clot: A Useful Technique in Diagnosis and Follow-Up of Hematological Disorders.

Case Rep Hematol 2019 10;2019:7590948. Epub 2019 Mar 10.

São Paulo State University (UNESP), Medical School of Botucatu, Department of Pathology, Botucatu, SP, Brazil.

Bone marrow biopsy is a diagnostic tool largely used in the evaluation of a broad number of disorders that could affect the hematopoietic system. Differently, bone marrow aspirate clot technique is rarely performed even though it has been described in literature. Here, we highlight the utility of the bone marrow aspirate clot, exemplifying through the discussion of three clinical cases in which this technique was used for diagnosis and follow-up purposes: megaloblastic hemopathy, multiple myeloma, and chronic lymphocytic leukemia. Read More

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http://dx.doi.org/10.1155/2019/7590948DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431525PMC
March 2019
1 Read

Chronic Benign CD8+ Proliferation: A Rare Affection that Can Mimic a Lymphoma Relapse.

Case Rep Hematol 2019 5;2019:4932616. Epub 2019 Mar 5.

Department of Molecular Biology and Genetics, University Hospital Brno, Faculty of Medicine, Masaryk University Brno, Brno, Czech Republic.

Chronic benign CD8+ proliferation is a rare syndrome that can take the form of a variety of other diseases. Peripheral adenopathy, cytopenia, and infiltration of the liver, kidneys, bowels, or other organs are the most common clinical presentations of the syndrome. CD8+ expansion can be clonal and nonclonal. Read More

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http://dx.doi.org/10.1155/2019/4932616DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425407PMC
March 2019
4 Reads

Development of Multiple Myeloma of the IgA Type in a Patient with Cold Agglutinin Disease: Transformation or Coincidence?

Case Rep Hematol 2019 4;2019:1610632. Epub 2019 Mar 4.

Department of Research and Innovation, Haugesund Hospital, Haugesund, Norway.

Cold agglutinin disease (CAD) is an autoimmune hemolytic anemia and a distinct, clonal bone marrow lymphoproliferative disorder, characterized in most cases by a monoclonal IgMκ serum protein. We describe a CAD patient presenting with a monoclonal immunoglobulin of the IgA class. For years, she remained asymptomatic apart from the hemolytic anemia until eventually she developed multiple myeloma (MM) of the IgA phenotype. Read More

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http://dx.doi.org/10.1155/2019/1610632DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425334PMC
March 2019
1 Read

A Case of Acquired Haemophilia A in a Patient with Chronic Myelomonocytic Leukaemia.

Case Rep Hematol 2019 27;2019:8612031. Epub 2019 Feb 27.

Department of Hematology and Oncology, Kita-Harima Medical Center, Hyogo, Japan.

A 67-year-old male, with a known diagnosis of myelodysplastic syndromes with multilineage dysplasia (MDS-MLD) was admitted to our hospital with a primary complaint of subcutaneous bleeding in his left thigh. Laboratory data showed anaemia and prolongation of activated partial thromboplastin time (85.8 s, normal range 24-39 s) without thrombocytopenia. Read More

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http://dx.doi.org/10.1155/2019/8612031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6415290PMC
February 2019
4 Reads

Mucormycosis as the Elusive Cause of an Aortic Thrombus and Tissue-Obliterating Abscess.

Case Rep Hematol 2019 19;2019:4842150. Epub 2019 Feb 19.

Department of Hematology-Oncology, Naval Medical Center San Diego, 34800 Bob Wilson Drive, San Diego, CA 92134, USA.

Invasive mucormycosis is an increasingly common cause of morbidity and mortality in hematologic malignancy patients. Early consideration of the diagnosis is essential in at-risk patients, exhibiting suggestive signs and symptoms. A 56-year-old female with acute myeloid leukemia initially presented with neutropenic fever before subsequently developing dense hemiplegia due to septic emboli to the spine and multifocal abscesses. Read More

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http://dx.doi.org/10.1155/2019/4842150DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6399552PMC
February 2019

Primary Cutaneous T-Cell Lymphoblastic Lymphoma: Case Report and Literature Review.

Case Rep Hematol 2019 20;2019:3540487. Epub 2019 Feb 20.

Mayo Clinic, Jacksonville, FL, USA.

Cutaneous involvement by precursor T-cell lymphoblastic leukemia/lymphoma (T-ALL/LBL) is rare, and almost all cases are seen in association with bone marrow, blood, and/or lymph node involvement. Presentation with isolated skin involvement is very rare. Literature review revealed only one case report of primary cutaneous T-cell LBL. Read More

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https://www.hindawi.com/journals/crihem/2019/3540487/
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http://dx.doi.org/10.1155/2019/3540487DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6402200PMC
February 2019
5 Reads

A Rare Presentation of HIV-Negative Plasmablastic Lymphoma: A Diagnostic Dilemma.

Case Rep Hematol 2019 13;2019:2907317. Epub 2019 Feb 13.

Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Plasmablastic lymphoma (PBL) and plasmablastic plasma cell myeloma (PCM) have many overlapping characteristics. Clinical correlation can help make the distinction between the two entities. Human immunodeficiency virus- (HIV-) negative PBL is a rare disease, making the diagnosis more challenging. Read More

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http://dx.doi.org/10.1155/2019/2907317DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6393929PMC
February 2019
1 Read

Autosplenectomy in a Patient with Paroxysmal Nocturnal Hemoglobinuria (PNH).

Case Rep Hematol 2019 12;2019:3146965. Epub 2019 Feb 12.

Houston Methodist Hospital, Department of Medicine, 6550 Fannin St, Houston, TX 77030, USA.

Autosplenectomy (AS) is a known complication of diseases such as sickle cell anemia, celiac disease, and inflammatory bowel disease. We report the first known case of AS due to paroxysmal nocturnal hemoglobinuria (PNH). A 24-year-old Caucasian male had evidence of hemolytic anemia at the age of 14 and was diagnosed with PNH at the age of 16. Read More

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http://dx.doi.org/10.1155/2019/3146965DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6390241PMC
February 2019
5 Reads

An Unusual Cause of Epistaxis: Paranasal Sinus Myeloid Sarcoma.

Case Rep Hematol 2019 12;2019:1312630. Epub 2019 Feb 12.

Department of Otolaryngology Head and Neck Surgery, The University of Tennessee Health Sciences Center, Memphis, USA.

We report a case of a 65-year-old female who presented with right-sided headaches, blurring of vision in the right eye, cold-induced epistaxis, and facial numbness in the trigeminal nerve distribution. Laboratory studies revealed a significant number of myeloblasts on peripheral smear with granulated cytoplasm, irregular nuclei, and prominent vacuoles. Magnetic resonance imaging (MRI) of the brain demonstrated a T1-enhancing 1. Read More

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http://dx.doi.org/10.1155/2019/1312630DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6390259PMC
February 2019
3 Reads

First Report of Hereditary Lysozyme Amyloidosis in a South Asian Family.

Case Rep Hematol 2019 10;2019:5092496. Epub 2019 Feb 10.

Department of Hematology and Oncology, Mayo Clinic, Jacksonville, FL, USA.

Lysozyme amyloidosis (ALys) is an exceedingly rare autosomal dominant hereditary type of systemic amyloidosis that can be misdiagnosed as other common types of systemic amyloidosis. The gastrointestinal tract and the kidney are the most common sites of organ involvement. No specific treatment exists for ALys, and the management primarily consists of organ-directed supportive care. Read More

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http://dx.doi.org/10.1155/2019/5092496DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6387725PMC
February 2019

Primary Cutaneous Diffuse Large B-Cell Lymphoma of the Upper Limb: Double Hit/Double Expressor with CNS Involvement: From Hospice to Remission.

Case Rep Hematol 2019 7;2019:3953470. Epub 2019 Feb 7.

Methodist Hospital, Texas Transplant Institute, San Antonio, Texas, USA.

We report a patient with diffuse large B-cell lymphoma of skin, nongerminal center type double hit double expressor, with an initial presentation as a left forearm mass. The patient underwent chemotherapy after initial diagnosis. After chemotherapy regimen, she developed a second mass, followed by CNS involvement with neurological defects. Read More

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http://dx.doi.org/10.1155/2019/3953470DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6383425PMC
February 2019
1 Read

Paroxysmal Nocturnal Hemoglobinuria with a Distinct Molecular Signature Diagnosed Ten Years after Allogenic Bone Marrow Transplantation for Acute Myeloid Leukemia.

Case Rep Hematol 2019 5;2019:8928623. Epub 2019 Feb 5.

Department of Clinical Hematology, Troyes General Hospital, 10000 Troyes, France.

Paroxysmal nocturnal hemoglobinurea (PNH) is a rare disorder of complement regulation due to somatic mutation of PIGA (phosphatidylinositol glycan anchor) gene. We herewith report a case who developed a symptomatic PNH long after an allogenic marrow transplant. Some reasonable arguments concerning the origin of PNH clone have been discussed. Read More

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https://www.hindawi.com/journals/crihem/2019/8928623/
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http://dx.doi.org/10.1155/2019/8928623DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6379860PMC
February 2019
3 Reads

Diagnostic and Treatment Challenges of Paroxysmal Nocturnal Hemoglobinuria in Uganda.

Case Rep Hematol 2019 31;2019:7897509. Epub 2019 Jan 31.

Department of Internal Medicine, Mbarara University of Science and Technology (MUST), Mbarara, Uganda.

Introduction: Paroxysmal nocturnal hemoglobinuria (PNH) is a very rare disorder of the hematopoietic stem cells which is often underdiagnosed. Its incidence is about 5 cases per million inhabitants in a year, and currently, there are only 1610 patients in the International PNH Registry. In this report, we describe a case of PNH in southwestern Uganda. Read More

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http://dx.doi.org/10.1155/2019/7897509DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374880PMC
January 2019
1 Read

Ceftriaxone-Induced Immune Hemolytic Anemia: In Vitro Reversal with Peptide Inhibitor of Complement C1 (PIC1).

Case Rep Hematol 2019 30;2019:4105653. Epub 2019 Jan 30.

Department of Pediatrics, Eastern Virginia Medical School, 700 West Olney Road, Norfolk, VA 23507, USA.

We report a case of ceftriaxone-induced immune hemolytic anemia in a 10-year-old with chronic active Epstein-Barr virus disease and hemophagocytic lymphohistiocytosis. After chemotherapy, she became febrile and received ceftriaxone. She rapidly developed respiratory failure and anemia. Read More

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http://dx.doi.org/10.1155/2019/4105653DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374879PMC
January 2019
1 Read

Relapse after Prolonged Remission in Philadelphia-Like Acute Lymphoblastic Leukemia.

Case Rep Hematol 2019 21;2019:3536517. Epub 2019 Jan 21.

Division of Hematology/Oncology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.

We describe a case of late relapse of Philadelphia-like acute lymphoblastic leukemia. The patient relapsed several years from diagnosis and responded to second salvage treatment. The case highlights the open questions regarding management of Philadelphia-like acute lymphoblastic leukemia. Read More

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http://dx.doi.org/10.1155/2019/3536517DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360594PMC
January 2019
2 Reads

Homozygous CALR Mutation in Primary Myelofibrosis and Its Effect on Disease Phenotype: A Case Report and Review of the Literature.

Case Rep Hematol 2019 20;2019:1430170. Epub 2019 Jan 20.

Department of Clinical Haematology, National Institute of Blood Diseases & Bone Marrow Transplantation, P.O. Box-75300, Karachi, Pakistan.

Somatic mutations in gene have been reported in 60%-88% of patients with essential thrombocythemia (ET) and primary myelofibrosis (PMF) who are negative for and mutations. Most of the mutations analyzed to date are heterozygous mutations in exon 9 of the gene. Homozygosity in gene is rarely reported, and its association with clinical behavior of disease and impact on outcome of patients is not studied so far. Read More

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http://dx.doi.org/10.1155/2019/1430170DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360597PMC
January 2019
3 Reads

Atypical Thrombotic Thrombocytopenic Purpura Presenting as Stroke.

Case Rep Hematol 2019 14;2019:7425320. Epub 2019 Jan 14.

Division of Hematology, Department of Internal Medicine, McGovern Medical School, The University of Texas Health Science Center at Houston, 6411 Fannin Street, Houston 77030, USA.

Here we report a case of atypical thrombotic thrombocytopenic purpura that presented as an ischemic cerebrovascular accident. A 56-year-old man with multiple cardiovascular risk factors presented with sudden left-sided weakness, slurred speech, and left facial droop. He showed mild improvement when he was treated with thrombolytic therapy according to the hospital stroke protocol. Read More

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http://dx.doi.org/10.1155/2019/7425320DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350572PMC
January 2019
5 Reads

Autoimmune-Associated Hemophagocytosis and Myelofibrosis in a Newly Diagnosed Lupus Patient: Case Report and Literature Review.

Case Rep Hematol 2019 9;2019:3879148. Epub 2019 Jan 9.

Section of Hematology, Department of Medicine, UP-Philippine General Hospital, Manila, Philippines.

Bone marrow abnormalities in SLE are now becoming increasingly recognized, suggesting that the bone marrow may also be an important site of target organ damage. In this study, we present a rare case of concurrent autoimmune hemophagocytic syndrome and autoimmune myelofibrosis, potentially life-threatening conditions, in a newly diagnosed SLE patient. We report a case of a 30-year-old Filipino woman who presented with a one-year history of fever, constitutional symptoms, exertional dyspnea, joint pains, and alopecia and physical examination findings of fever, facial flushing, cervical lymphadenopathies, and knee joint effusions. Read More

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http://dx.doi.org/10.1155/2019/3879148DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343163PMC
January 2019
7 Reads

Chronic Lymphocytic Leukemia Presenting as a Subcortical Watershed Infarct.

Case Rep Hematol 2019 9;2019:2089359. Epub 2019 Jan 9.

Internal Medicine, Monmouth Medical Center, Long Branch, New Jersey, USA.

Internal watershed infarcts (WI) involve white matter between deep and superficial arterial systems of middle cerebral artery. These infarcts are considered to be either from low blood flow or microembolism. Anemia is an extremely rare cause of watershed infarcts. Read More

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https://www.hindawi.com/journals/crihem/2019/2089359/
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http://dx.doi.org/10.1155/2019/2089359DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343168PMC
January 2019
15 Reads

False-Negative Platelet Factor 4 Antibodies and Serotonin Release Assay and the Utility of Repeat Testing in the Diagnosis of Heparin-Induced Thrombocytopenia and Thrombosis.

Case Rep Hematol 2019 8;2019:1585014. Epub 2019 Jan 8.

Department of Neurointensive Care, Cerebrovascular Center, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, Ohio 44195, USA.

Objective: To report a case of false-negative serological tests in the diagnosis of heparin-induced thrombocytopenia (HIT) followed by a brief review of the literature on this topic.

Case Presentation: A 75-year-old Caucasian female patient was admitted with a traumatic right ankle fracture that required open reduction and internal fixation. Despite postoperative subcutaneous heparin chemoprophylaxis, she developed deep vein thrombosis (DVT) and pulmonary embolism (PE) on day 4 and subsequently started on continuous heparin infusion. Read More

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http://dx.doi.org/10.1155/2019/1585014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341253PMC
January 2019
4 Reads

The Implications of Liver Biopsy Results in Patients with Myeloproliferative Neoplasms Being Treated with Ruxolitinib.

Case Rep Hematol 2019 6;2019:3294046. Epub 2019 Jan 6.

Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Ruxolitinib is increasingly being utilized for the treatment of myelofibrosis and polycythemia vera, but the potential for hepatic toxicity is poorly understood. We performed a retrospective review of hepatic damage occurring in patients with myeloproliferative neoplasms receiving ruxolitinib. Relevant histologic images of liver biopsies were reviewed by an experienced liver pathologist and reported to a multidisciplinary team including hepatology and hematology. Read More

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http://dx.doi.org/10.1155/2019/3294046DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339753PMC
January 2019
2 Reads

Durable Leukemic Remission and Autologous Marrow Recovery with Random Chromosomal Abnormalities after Allogeneic Hematopoietic Stem Cell Transplantation for Chronic Lymphocytic Leukemia.

Case Rep Hematol 2019 3;2019:9710790. Epub 2019 Jan 3.

Department of Hematology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.

A 38-year-old woman with aggressive clinical course of chronic lymphocytic leukemia (CLL) was treated with 8 courses of R-CHOP. Clinical remission was achieved, while B-cell clonality remained. Allogeneic hematopoietic stem cell transplantation was performed with reduced intensity conditioning (fludarabine and 2-Gy total body irradiation). Read More

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http://dx.doi.org/10.1155/2019/9710790DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6335663PMC
January 2019
3 Reads

Thrombotic Thrombocytopenic Purpura due to Checkpoint Inhibitors.

Case Rep Hematol 2018 20;2018:2464619. Epub 2018 Dec 20.

The T.W. Lewis Melanoma Center of Excellence, Banner MD Anderson Cancer Center, Gilbert, AZ, USA.

Ipilimumab is a monoclonal antibody that enhances the efficacy of the immune system by targeting a cytotoxic T-lymphocyte-associated protein 4 (CTLA-4), which is a protein receptor that downregulates the immune system. Nivolumab is also a humanized monoclonal antibody that targets another protein receptor that prevents activated T cells from attacking the cancer; this receptor is called programmed cell death 1 (PD-1). The FDA approved ipilimumab combined with nivolumab as a frontline therapy for patients with metastatic melanoma or renal cell carcinoma and as a second-line therapy for patients with microsatellite instability-high (MSI-H) metastatic colon cancer. Read More

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http://dx.doi.org/10.1155/2018/2464619DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317083PMC
December 2018
3 Reads

The Use of Natural Health Products Especially Papaya Leaf Extract and Dandelion Root Extract in Previously Untreated Chronic Myelomonocytic Leukemia.

Case Rep Hematol 2018 18;2018:7267920. Epub 2018 Dec 18.

Department of Hematologic Malignancies and Blood and Marrow Transplant, University of California, San Francisco, CA, USA.

Chronic myelomonocytic leukemia (CMML) is a clonal hematopoietic disorder which shares clinical and morphological features of myelodysplastic syndrome and myeloproliferative neoplasms. Conventional therapeutic options include hydroxyurea, hypomethylating agents, and systemic chemotherapy, which are all palliative measures and are associated with potential side effects. Allogeneic hematopoietic cell transplantation is the only curative option. Read More

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http://dx.doi.org/10.1155/2018/7267920DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6312608PMC
December 2018
2 Reads

An Unusual Coexistence of Primary Central Nervous System Non-Hodgkin's Lymphoma and Acute Promyelocytic Leukemia.

Case Rep Hematol 2018 19;2018:2741939. Epub 2018 Dec 19.

Nicola Stefano Fracchiolla, Mariarita Sciumè, Agostino Cortelezzi, Hematology Unit, Fondazione IRCCS Ca'Granda Ospedale Maggiore Policlinico, Via Francesco Sforza, 35, 20122 Milan, Italy.

Acute promyelocytic leukemia and primary central nervous system lymphoma are uncommon hematological malignancies. The co-occurrence of acute myeloid leukemia with various lymphoproliferative diseases is an extremely rare condition, especially in the absence of previous chemotherapy or radiotherapy. Herein, we provide a comprehensive characterization of a patient with concomitant diagnosis of extranodal high-grade non-Hodgkin B-cell neoplasm confined to the central nervous system and acute promyelocytic leukemia. Read More

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http://dx.doi.org/10.1155/2018/2741939DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6313991PMC
December 2018
3 Reads

Cyclin-Dependent Kinase 4/6 Inhibitor (Palbociclib) Induced Aplastic Anemia in a Patient with Metastatic Breast Cancer.

Case Rep Hematol 2018 13;2018:9249506. Epub 2018 Dec 13.

Section of Hematology and Medical Oncology, Department of Medicine, Boston Medical Center, Boston, Massachusetts, USA.

Breast cancer is the most common cancer diagnosed in women worldwide. Over the years, breast cancer treatment has undergone revolutionary changes especially for women with hormone receptor positive metastatic disease. As a result, women are living longer with their disease, particularly in developed countries. Read More

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https://www.hindawi.com/journals/crihem/2018/9249506/
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http://dx.doi.org/10.1155/2018/9249506DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311830PMC
December 2018
10 Reads

A Rare Case of Triple-Negative Essential Thrombocythemia in a Young Postsplenectomy Patient: A Diagnostic Challenge.

Case Rep Hematol 2018 16;2018:9079462. Epub 2018 Dec 16.

Division of Hematology, University of Texas Health Science Center at Houston, Houston, TX, USA.

The distinction between primary and reactive thrombocytosis by bone marrow histology is very important. Reactive thrombocytosis, the most common cause of thrombocytosis, can be expected in postsplenectomy states; however, close hematological evaluation of prolonged thrombocytosis is essential to identify patients who may have an underlying myeloproliferative neoplasm. We report a 37-year-old woman who was found to have portal, mesenteric, and splenic vein thrombosis with thrombocytosis, two months after she had a splenectomy for spontaneous splenic rupture. Read More

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http://dx.doi.org/10.1155/2018/9079462DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311807PMC
December 2018
3 Reads

Dysphagia as an Unusual Presentation of Myeloma.

Case Rep Hematol 2018 13;2018:6910624. Epub 2018 Dec 13.

Otorhinolaryngology Department, Avicenna Military Hospital, Marrakech, Morocco.

Multiple myeloma is a plasma cell dyscrasis characterized by mature B cells proliferation in the bone marrow. In rare cases, the disease can present as an extramedullary location, making diagnosis and management more challenging. Here, we describe a rare case of tongue extramedullary myeloma and discuss diagnostic, prognostic, and therapeutic issues. Read More

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http://dx.doi.org/10.1155/2018/6910624DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311888PMC
December 2018
3 Reads

A Case of Myeloproliferative Neoplasm with BCR-FGFR1 Rearrangement: Favorable Outcome after Haploidentical Allogeneic Transplantation.

Case Rep Hematol 2018 6;2018:5724960. Epub 2018 Dec 6.

Cytogenetic Unit, Hospital Universitario de La Princesa, Madrid, Spain.

Hematopoietic myeloproliferative neoplasms with FGFR1 rearrangement result in the 8p11 myeloproliferative syndrome that in the current Word Health Organization classification is designated as "myeloid and lymphoid neoplasm with FGFR1 abnormalities." We report the case of a 66-year-old man who had clinical features that resembled chronic myeloid leukaemia (CML), but bone marrow cytogenetic and fluorescent in situ hybridization (FISH) studies showed t(8;22)(p11;q11) and BCR-FGFR1 fusion gene. He was initially managed with hydroxyurea, and given the aggressive nature of this disease, four months later, the patient underwent an allogeneic hematopoietic stem-cell transplantation (HSCT) from an HLA-haploidentical relative. Read More

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http://dx.doi.org/10.1155/2018/5724960DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311782PMC
December 2018
3 Reads

Obstructive Jaundice due to Pancreatic Involvement as an Initial Presentation of Adult Acute Lymphoblastic Leukemia.

Case Rep Hematol 2018 4;2018:9175360. Epub 2018 Dec 4.

Leighton Hospital NHS Trust, Crewe, Cheshire, UK.

Acute lymphoblastic leukemia (ALL) is a heterogeneous group of lymphoid disorders characterized by monoclonal proliferation and expansion of immature lymphoid cells in the bone marrow, blood, and other organs. It commonly presents with nonspecific symptoms such as lethargy, easy bruising, and weight loss. In this article, we present the case of a 48-year-old male who presented to the hospital with painless jaundice resulting from pancreatic infiltration, initially thought to be due to pancreatic or hepatobiliary malignancy. Read More

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http://dx.doi.org/10.1155/2018/9175360DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304853PMC
December 2018
1 Read

Blastoid Variant Mantle Cell Lymphoma Expressing Aberrant CD3 and CD10 with Concurrent Small Lymphocytic Lymphoma: Establishment of a Clonal Relationship by B- and T-Cell Receptor Gene Rearrangements.

Case Rep Hematol 2018 5;2018:8303571. Epub 2018 Dec 5.

Medical Oncology and Hematology, 7777 Milliken Avenue Suite 210, Rancho Cucamonga, CA 91730, USA.

Mantle cell lymphoma (MCL) is an aggressive non-Hodgkin B-cell lymphoma typically expressing CD19, CD20, CD5, FMC-7, CyclinD1, and SOX-11 and harboring the IgH/CCND1 translocation. We report a blastoid variant of mantle cell lymphoma (MCL) involving an inguinal lymph node that, in addition to classical phenotypic and genetic findings, also aberrantly coexpresses surface CD10 and cytoplasmic CD3. Small lymphocytic lymphoma (SLL) was also present in the same lymph node and in the bone marrow. Read More

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http://dx.doi.org/10.1155/2018/8303571DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6305046PMC
December 2018
5 Reads

Efficacy of Carfilzomib, Lenalidomide, and Dexamethasone for Extramedullary Intracranial Localization of Multiple Myeloma.

Case Rep Hematol 2018 29;2018:2312430. Epub 2018 Nov 29.

Department of Haematology and BMT Unit, Antonio Perrino Hospital, Brindisi, Italy.

EMD of myeloma usually occurs several years after diagnosis and is associated with a very poor OS of <6 months due to the fact that there are no efficient treatment options. In rrMM with EMDs, the most effective treatment is a lymphoma-like polychemotherapy regimen such as PACE, Dexa-BEAM, and HyperCVAD followed by ASCT or allogeneic SCT. RT of soft-tissue plasmacytoma is the further treatment choice and results in a high rate of local control and a prolonged disease-free survival. Read More

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http://dx.doi.org/10.1155/2018/2312430DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304832PMC
November 2018
10 Reads

Philadelphia Translocation in MDS: A Case Report and a Brief Review of the Literature Looking at Its Prevalence, Disease Progression, and Treatment Options.

Case Rep Hematol 2018 22;2018:5865321. Epub 2018 Nov 22.

SSM Health St. Mary's Hospital, St. Louis, Missouri 63117, USA.

Myelodysplastic syndrome (MDS) is a group of clonal disorders characterized by ineffective and dysplastic hematopoiesis in the bone marrow with variable risk of progression to leukemia. MDS is characterized by specific karyotypic and molecular abnormalities. The t(9 : 22) Philadelphia translocation is not a common abnormality found in MDS, and it is not included in the prognostic indices for germline mutations. Read More

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http://dx.doi.org/10.1155/2018/5865321DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6282134PMC
November 2018
1 Read

Rare Coexistence of Acute Monoblastic Leukemia with Chronic Lymphocytic Leukemia.

Case Rep Hematol 2018 6;2018:6452843. Epub 2018 Nov 6.

Associate Consultant, Department of Hematooncology, Artemis Hospitals, Gurgaon, India.

Acute monoblastic leukemia (AMoL) is a rare hematopoietic neoplasm, and simultaneous occurrence of acute monoblastic leukemia with chronic lymphocytic leukemia is very rare and only a few cases have been reported in the literature. We here report a rare case of dual hematological malignancy in an 85-year-old male. The peripheral blood and bone marrow examination revealed dual population of atypical cells, comprising large cells with opened-up chromatin having monocytic appearance and small mature-appearing lymphocytes. Read More

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https://www.hindawi.com/journals/crihem/2018/6452843/
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http://dx.doi.org/10.1155/2018/6452843DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6247670PMC
November 2018
11 Reads

Is There a Role for Biweekly Romiplostim in the Management of Chronic Immune Thrombocytopenia (ITP)? A Report of Three Cases.

Case Rep Hematol 2018 24;2018:6037494. Epub 2018 Oct 24.

Division of Hematology, Department of Medicine, The Ottawa Hospital, Ottawa, Ontario, Canada.

Romiplostim is a peptibody, which stimulates platelet production by a mechanism similar to that of endogenous thrombopoietin. It has an established indication as second-line therapy in patients with chronic immune thrombocytopenia (ITP). The agent is typically administered weekly; however, there are instances where a biweekly (i. Read More

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https://www.hindawi.com/journals/crihem/2018/6037494/
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http://dx.doi.org/10.1155/2018/6037494DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6247720PMC
October 2018
10 Reads

Plasmablastic Lymphoma in an Immunocompetent Patient with MDS/MPN with Ring Sideroblasts and Thrombocytosis-A Case Report.

Case Rep Hematol 2018 4;2018:2525070. Epub 2018 Nov 4.

Second Department of Internal Medicine and Research Unit, University General Hospital "Attikon", 1 Rimini St., Haidari, 12462 Athens, Greece.

Plasmablastic lymphoma (PBL) is a rare, aggressive type of B-cell non-Hodgkin lymphoma with the vast majority of patients responding poorly to treatment or progressing shortly thereafter. Cyclophosphamide-doxorubicin-vincristine-prednisolone (CHOP) or CHOP-like regimens have disappointing results in this setting. We report a case of PBL arising in a previously diagnosed myelodysplastic/myeloproliferative (MDS/MPN) with ring sideroblasts and thrombocytopenia (RS-T), HIV-negative patient treated with the combination of CHOP and bortezomib. Read More

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http://dx.doi.org/10.1155/2018/2525070DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6247723PMC
November 2018
3 Reads

Paroxysmal Cold Hemoglobinuria in an Adult with Respiratory Syncytial Virus.

Case Rep Hematol 2018 13;2018:7586719. Epub 2018 Nov 13.

Division of Hematology and Medical Oncology, Department of Medicine, Mount Sinai Beth Israel, Mount Sinai Hospital, New York, NY, USA.

Paroxysmal cold hemoglobinuria (PCH) is a rare form of cold autoimmune hemolytic anemia first discovered in the early 20th century in adults with tertiary syphilis. Today, it is more commonly seen in children as a life-threatening anemia during a viral upper respiratory tract infection (URI). Although respiratory syncytial virus (RSV) has previously been reported to cause PCH in a child, herein we present the first documented case in an adult. Read More

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http://dx.doi.org/10.1155/2018/7586719DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6257899PMC
November 2018
16 Reads

Management of Acquired Hemophilia A in Elderly Patients.

Case Rep Hematol 2018 13;2018:6757345. Epub 2018 Nov 13.

Division of Hematology, Takasago-Seibu Hospital, Takasago 676-0812, Japan.

This report describes six elderly patients with acquired hemophilia A (AHA), including four individuals aged ≥90 years. Bleeding symptoms were subcutaneous or intramuscular hemorrhage (=4), hematuria (=1), and hemorrhagic shock after tooth extraction (=1). Factor VIII (FVIII) activity ranged from <1. Read More

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http://dx.doi.org/10.1155/2018/6757345DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6260550PMC
November 2018
1 Read

Transitory Spontaneous Remission of Myelodysplasia in an Elderly Man while Receiving Intravesical Bacillus Calmette-Guérin for Bladder Cancer: A Case Report and Review of the Literature.

Case Rep Hematol 2018 11;2018:9750532. Epub 2018 Nov 11.

Physician, General Medicine, Hospital de Carabineros de Chile, Simón Bolívar 2200, Ñuñoa 7770199, Santiago, Chile.

Myelodysplasia is a clonal disorder characterized by progressive cytopenias. Intravescial BCG is standard immunotherapy for superficial bladder cancer. We present a patient with transfusion-dependent myelodysplasia whose blood counts normalized during treatment with intravesical BCG for bladder cancer. Read More

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http://dx.doi.org/10.1155/2018/9750532DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6252232PMC
November 2018
3 Reads

Composite Lymphoma Comprising Extranodal NK/T-Cell Lymphoma and Diffuse Large B-Cell Lymphoma.

Case Rep Hematol 2018 31;2018:1583925. Epub 2018 Oct 31.

Department of Hematology, Toyota Kosei Hospital, Toyota, Japan.

We report a rare case of composite lymphoma comprising extranodal NK/T-cell lymphoma, nasal type, (ENKL) and diffuse large B-cell lymphoma (DLBCL) in a 70-year-old man complaining of fatigue. Computed tomography showed multiple consolidations in both lungs, and ENKL was diagnosed from transbronchial lung biopsy. Positron emission tomography also detected abnormal uptake in the stomach, and DLBCL was diagnosed from subsequent gastroscopy. Read More

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http://dx.doi.org/10.1155/2018/1583925DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6234446PMC
October 2018
2 Reads

Pompe Disease Could Mimic Exam Findings of Amyloidosis: Two Rare Diagnoses Bona Fide.

Case Rep Hematol 2018 28;2018:9615834. Epub 2018 Oct 28.

Department of Internal Medicine, Mayo Clinic, Rochester, MN, USA.

A 70-year-old female presented with a three-year history of evolving macroglossia causing dysphagia and dysarthria, with proximal muscle weakness. Given the classic physical finding of macroglossia, the patient underwent extensive evaluation for amyloidosis which proved to be negative apart from a bone marrow biopsy which stained positive for transthyretin without amino acid sequence abnormality, thus giving wild-type transthyretin amyloidosis. Since the wild-type transthyretin amyloidosis could not entirely explain her clinical presentation and evaluation, further studies were conducted in a sequential manner, thus leading to a diagnosis of Pompe disease explaining her presenting signs and symptoms including her macroglossia. Read More

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http://dx.doi.org/10.1155/2018/9615834DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6230410PMC
October 2018
2 Reads

A Case of Posttransfusion Purpura with Severe Refractory Thrombocytopenia but No Cutaneous Manifestations.

Case Rep Hematol 2018 29;2018:8187659. Epub 2018 Oct 29.

Department of Immunology and Transfusion Medicine, Oslo University Hospital, Oslo, Norway.

Posttransfusion purpura is a serious adverse effect of transfusion due to HPA-antibodies. A young female was diagnosed with acute leukaemia, and treatment commenced. Severe thrombocytopenia ensued. Read More

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http://dx.doi.org/10.1155/2018/8187659DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6231382PMC
October 2018
2 Reads

Erratum to "A Case of Bing-Neel Syndrome Successfully Treated with Ibrutinib".

Case Rep Hematol 2018 29;2018:7610201. Epub 2018 Oct 29.

Center for Lymphoid Malignancies, Columbia University Medical Center, College of Physicians and Surgeons, New York, NY, USA.

[This corrects the article DOI: 10.1155/2018/8573105.]. Read More

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http://dx.doi.org/10.1155/2018/7610201DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6231375PMC
October 2018
1 Read

Solitary Lytic Bone Metastasis: A Rare Presentation of Small Lymphocytic Leukemia.

Case Rep Hematol 2018 30;2018:6154709. Epub 2018 Oct 30.

Department of Hematology/Oncology, Joan C. Edwards School of Medicine Marshall University, 1600 Medical Center Dr, Huntington, WV 25701, USA.

Chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL) is a hematologic malignancy characterized by an over accumulation of incompetent neoplastic lymphocytes. Bone metastasis in CLL/SLL is very rare. We report a case of a 76-year-old Caucasian female presented with an unresolving pulmonary infiltrate with mediastinal lymphadenopathy concerning for malignancy. Read More

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http://dx.doi.org/10.1155/2018/6154709DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6232806PMC
October 2018
5 Reads

Progressive Intramuscular Haematoma in a 12-Year-Old Boy: A Case of Acquired Haemophilia A.

Case Rep Hematol 2018 24;2018:6208597. Epub 2018 Oct 24.

Senior Registrar, Department of Pathology, Faculty of Medical Sciences, University of Sri Jayewardenepura, Nugegoda, Sri Lanka.

Acquired hemophilia A (AHA) is a rare bleeding disorder due to acquired antibodies against coagulation factor VIII (FVIII). It is rare in children less than 16 years old, and the incidence is 0.45/million/year. Read More

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https://www.hindawi.com/journals/crihem/2018/6208597/
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http://dx.doi.org/10.1155/2018/6208597DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6220402PMC
October 2018
11 Reads

Drug-Induced Hypersensitivity Syndrome: A Clinical, Radiologic, and Histologic Mimic of Lymphoma.

Case Rep Hematol 2018 21;2018:7037352. Epub 2018 Oct 21.

Department of Pathology, The University of Oklahoma Health Sciences Center, 940 Stanton L. Young Boulevard, BMSB 451, Oklahoma City, OK 73104, USA.

Drug-induced hypersensitivity syndrome (DIHS; also known as drug reaction with eosinophilia and systemic symptoms, or DRESS) is a rare, potentially life-threatening condition that typically presents 2-8 weeks after drug exposure with fever, rash, organ dysfunction, and lymphadenopathy. Here, we describe the case of an 18-year-old African American female who presented with cervical lymphadenopathy, fevers, and a macular rash. A PET scan showed diffuse hypermetabolic lymphadenopathy suggestive of lymphoma, with involvement of the spleen and kidneys. Read More

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http://dx.doi.org/10.1155/2018/7037352DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6215581PMC
October 2018
2 Reads

Suspected Pericardial Tuberculosis Revealed as an Amyloid Pericardial Mass.

Case Rep Hematol 2018 17;2018:8606430. Epub 2018 Oct 17.

Department of Biomedical Sciences and Human Oncology, Section of Internal Medicine "G. Baccelli", University of Bari Aldo Moro Medical School, Bari, Italy.

Primary systemic amyloidosis is not easily diagnosed. The immunoglobulin deposits are usually localized in the kidney, heart, and liver. We describe an unusual case of a patient suffering from a pericardial amyloidoma with internal calcifications and air bubbles that compressed the right ventricle and shifted the heart to the left. Read More

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https://www.hindawi.com/journals/crihem/2018/8606430/
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http://dx.doi.org/10.1155/2018/8606430DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6207883PMC
October 2018
20 Reads