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    429 results match your criteria Case reports in hematology[Journal]

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    Morphological Transformation of Myeloma Cells into Multilobated Plasma Cell Nuclei within 7 Days in a Case of Secondary Plasma Cell Leukemia That Finally Transformed as Anaplastic Myeloma.
    Case Rep Hematol 2017 21;2017:5758368. Epub 2017 Dec 21.
    Department of Hematology and Oncology, Oji General Hospital, Tomakomai, Japan.
    A 48-year-old man was diagnosed with multiple myeloma (IgG-k) and was treated with high-dose dexamethasone as an induction therapy followed by thalidomide-based regimens. Approximately 22 months after the initial diagnosis, the patient developed secondary plasma cell leukemia (PCL) with a white blood cell (WBC) count of 20.2 × 10/L including 79. Read More

    Peripheral T-Cell Lymphoma of the Submandibular Salivary Gland as an Unusual Manifestation of Richter's Syndrome: A Case Report and Literature Review.
    Case Rep Hematol 2017 3;2017:1262368. Epub 2017 Dec 3.
    Department of Pathology, N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, Kashirskoye shosse 24, Moscow 115478, Russia.
    Richter's syndrome is the development of high-grade non-Hodgkin lymphoma (NHL) or Hodgkin lymphoma in patients with chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL). In most patients with Richter's syndrome, the high-grade NHL is diffuse large B-cell lymphoma. Only a small minority of CLL/SLL patients develop T-cell malignancies. Read More

    Sequential Use of Second-Generation Tyrosine Kinase Inhibitor Treatment and Intensive Chemotherapy Induced Long-Term Complete Molecular Response in Imatinib-Resistant CML Patient Presenting as a Myeloid Blast Crisis.
    Case Rep Hematol 2017 17;2017:3209305. Epub 2017 Dec 17.
    Department of Hematology and Immunology, Otsu Red Cross Hospital, 1-1-35, Nagara, Otsu-shi, Shiga, Japan.
    Myeloid blast crisis of chronic myeloid leukemia (CML-MBC) is rarely seen at presentation and has a poor prognosis. There is no standard therapy for CML-MBC. It is often difficult to distinguish CML-MBC from acute myeloid leukemia expressing the Philadelphia chromosome (Ph+ AML). Read More

    Sickle Cell Beta-Plus Thalassemia with Subcapsular Hematoma of the Spleen.
    Case Rep Hematol 2017 14;2017:3819457. Epub 2017 Dec 14.
    Maimonides Medical Center, Brooklyn, NY, USA.
    While splenic complications like hypersplenism, sequestration crisis, and infarction are commonly reported in sickle cell variants like sickle cell beta-plus thalassemia, splenic rupture with hematoma is rare. We present a case of a 32-year-old young male who presented with dull left upper quadrant pain who was found to have multiple subcapsular splenic lacerations and hematoma on abdominal imaging. Hemoglobin electrophoresis confirmed sickle cell beta-plus thalassemia in the patient. Read More

    Plasmablastic Lymphoma with Coexistence of Chronic Lymphocytic Leukemia in an Immunocompetent Patient: A Case Report and Mini-Review.
    Case Rep Hematol 2017 20;2017:2861596. Epub 2017 Nov 20.
    Department of Hematology, University Hospital of Ioannina, Ioannina, Greece.
    Background: Plasmablastic lymphoma (PBL) is a rare, aggressive B-cell lymphoma with poor prognosis usually found in the oral cavity of HIV-positive patients. Chronic lymphocytic leukemia (CLL) is an indolent B-cell lymphoma with a variable clinical course. Transformation of CLL to PBL as Richter's syndrome is rare while coexistence of CLL and PBL at diagnosis is even rarer. Read More

    Late Emergence of an Imatinib-ResistantKinase Domain Mutation in a Patient with Chronic Myeloid Leukemia.
    Case Rep Hematol 2017 11;2017:3548936. Epub 2017 Dec 11.
    Cancer Molecular Diagnostics, St. James's Hospital, Dublin 8, Ireland.
    The introduction of the tyrosine kinase inhibitor (TKI) imatinib has revolutionised the outlook of chronic myeloid leukemia (CML); however, a significant proportion of patients develop resistance through several mechanisms, of which acquisition ofkinase domain mutations is prevalent. In chronic-phase patients, these mutations become evident early in the disease course. A case is described of a chronic-phase CML patient who achieved a sustained, deep molecular response but who developed an Y253Hkinase domain mutation nearly nine years after commencing imatinib. Read More

    Waldenstrom's Macroglobulinemia: A Report of Two Cases, One with Severe Retinopathy and One with Renal Failure.
    Case Rep Hematol 2017 31;2017:3732902. Epub 2017 Oct 31.
    Division of Hematology, Takasago-seibu Hospital, Takasago 676-0812, Japan.
    We report here two cases of Waldenstrom's macroglobulinemia (WM), one with central nervous system (CNS) symptoms and severe retinopathy and one with renal failure. In both cases, the serum IgM levels exceeded 3,000 mg/dL and monoclonal IgM-kappa was observed in the blood. At onset, Case 1, a 63-year-old female, developed CNS symptoms-namely, drowsiness and syncope. Read More

    Erdheim-Chester Disease with No Skeletal Bone Involvement and Massive Weight Loss.
    Case Rep Hematol 2017 30;2017:3862052. Epub 2017 Oct 30.
    Division of Hematology and HSCT, Department of Oncology, King Abdulaziz Medical City, Riyadh, Saudi Arabia.
    Erdheim-Chester disease (ECD) is a rare type of non-Langerhans cell histiocytosis, with only 550 cases reported worldwide. ECD is characterized by diffuse histiocytic infiltration of multiorgans. The age of presentation of this disease is typically between 40 and 70 years. Read More

    Severe Cytomegalovirus Reactivation in Patient with Low-Grade Non-Hodgkin's Lymphoma after Standard Chemotherapy.
    Case Rep Hematol 2017 22;2017:5762525. Epub 2017 Oct 22.
    Department of Haematology, Warwick Hospital, Warwick, UK.
    Clinically significant cytomegalovirus (CMV) reactivation is not uncommon in patients with severe immunodeficiency secondary to underlying medical disorders or following aggressive immunosuppressive therapy. However, it is less frequently found in patients with low-grade haematological malignancies after nonintensive chemotherapy. We treated a patient at our centre for stage IVB follicular lymphoma with standard chemotherapy who successively developed CMV colitis associated with a CMV viral load of >3 million copies/ml. Read More

    CD56-Negative Aggressive NK Cell Leukemia Relapsing as Multiple Cranial Nerve Palsies: Case Report and Literature Review.
    Case Rep Hematol 2017 15;2017:3724017. Epub 2017 Oct 15.
    Department of Hematology, Laboratory of Cytometry, Hospital de Santo António, Centro Hospitalar do Porto, Rua D. Manuel II, s/n, 4099-001 Porto, Portugal.
    Background: Aggressive natural killer cell leukemia (ANKL) is extremely rare and habitually manifests as a systemic disease with multiorgan failure that rapidly evolves to death. The neoplastic natural killer (NK) cells usually harbor the Epstein-Barr virus (EBV) with a latent viral infection pattern type II; they often have a cytoplasmic CD3and surface CD3, CD2, and CD56immunophenotype, and they show complex genetic abnormalities affecting multiple tumor suppressor genes and oncogenes. We present a rare case of CD56-negative ANKL and review the clinical and laboratorial criteria for the diagnosis, as well as the available therapies. Read More

    Acquired Elliptocytosis as a Manifestation of Myelodysplastic Syndrome with Ring Sideroblasts and Multilineage Dysplasia.
    Case Rep Hematol 2017 11;2017:3625946. Epub 2017 Oct 11.
    Department of Internal Medicine, Division of Hematology and Oncology, University of California Davis Medical Center, Sacramento, CA 98517, USA.
    Acquired elliptocytosis is a known but rarely described abnormality in the myelodysplastic syndromes (MDS). Here we report the case of an elderly male who was admitted to the hospital with chest pain, dyspnea, and fatigue and was found to be anemic with an elliptocytosis that had only recently been noted on peripheral smears of his blood. After bone marrow biopsy he was diagnosed with MDS with ring sideroblasts and multilineage dysplasia and acquired elliptocytosis. Read More

    Splenic Infarct and Pulmonary Embolism as a Rare Manifestation of Cytomegalovirus Infection.
    Case Rep Hematol 2017 11;2017:1850821. Epub 2017 Oct 11.
    Department of Pharmacology, St. John's Medical College, Bangalore, India.
    Cytomegalovirus (CMV) is a type of herpes infection that has a characteristic feature of maintaining lifelong latency within the host cell. CMV manifestations can cover a broad spectrum from fever to as severe as pancytopenia, hepatitis, retinitis, meningoencephalitis, Guillain-Barre syndrome, pneumonia, and thrombosis. Multiple case reports of thrombosis associated with CMV have been reported. Read More

    Unusual Presentation of a Small-Cell Variant of Anaplastic Large-Cell Lymphoma Case: When a Septic Picture Is Not Sepsis.
    Case Rep Hematol 2017 24;2017:7292148. Epub 2017 Sep 24.
    Department of Hematology and Oncology, William Beaumont Hospital, Royal Oak, MI, USA.
    We report a case of a small-cell variant of anaplastic large-cell lymphoma, with an unusual clinical presentation mimicking sepsis and a fulminant clinic course, in a 48-year-old Caucasian female. In this report, we discuss the diagnostic challenge, histopathologic features, and unique cytogenetic features of this case, in order to raise awareness of this rare presentation and emphasize the importance of meticulous peripheral smear examination and early bone marrow evaluation. Read More

    Upper Limb Deep Vein Thrombosis in Patient with Hemophilia A and Heterozygosity for Prothrombin G20210A: A Case Report and Review of the Literature.
    Case Rep Hematol 2017 25;2017:7290945. Epub 2017 Sep 25.
    Department of Medicine, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.
    Deep vein thrombosis (DVT) is a rare disease in patients with hemophilia A. We report a case of 22-year-old male with severe hemophilia A who presented to the emergency room with 5-day history of right arm pain that was attributed initially to bleeding event. In the absence of external signs of bleeding or hematoma and normal hemoglobin level, we suspected an underlying DVT. Read More

    Paroxysmal Nocturnal Hemoglobinuria in Pregnancy: A Dilemma in Treatment and Thromboprophylaxis.
    Case Rep Hematol 2017 24;2017:7289126. Epub 2017 Sep 24.
    Department of Medicine, Division of Hematology & Oncology, University of Florida, Gainesville, FL, USA.
    Paroxysmal nocturnal hemoglobinuria (PNH) is a hematologic disorder characterized by an acquired somatic mutation in the phosphatidylinositol glycan class A gene which leads to a higher risk for increased venous and arterial thrombosis. Current treatment for PNH includes eculizumab. Pregnant patients who have PNH have higher risk for thrombosis and hemorrhage with both pregnancy and their underlying PNH. Read More

    T-Cell Acute Lymphoblastic Leukemia/Lymphoma: Discussion of Two Pediatric Cases and Its Distinction from Other MatureT-Cell Malignancies.
    Case Rep Hematol 2017 24;2017:5873015. Epub 2017 Sep 24.
    Department of Pathology and Translational Pathobiology, LSU Health Shreveport, Shreveport, LA, USA.
    Gamma delta () T-cell antigen receptor (TCR) expression and its related T-cell differentiation are not commonly reported in T-cell acute lymphoblastic leukemia/lymphoma (T-ALL). Here we report two pediatric T-ALL cases and present their clinical features, histology, immunophenotypes, cytogenetics, and molecular diagnostic findings. The first patient is a two-year-old girl with leukocytosis, circulating lymphoblasts, and a cryptic insertion of a short-arm segment at 10p12 into the long-arm segment of 11q23 resulting in an MLL and AF10 fusion transcript, which may be the first reported inT-ALL. Read More

    Chronic Myeloid Leukemia with an e6a2Fusion Transcript: Cooperating Mutations at Blast Crisis and Molecular Monitoring.
    Case Rep Hematol 2017 16;2017:9071702. Epub 2017 Oct 16.
    Cancer Molecular Diagnostics, St. James's Hospital, Dublin 8, Ireland.
    A minority of chronic myeloid leukemia patients (CML) express a variety of atypicalfusion variants and, of these, the e6a2fusion is generally associated with an aggressive disease course. Progression of CML to blast crisis is associated with acquisition of additional somatic mutations yet these events have not been elucidated in patients with the e6a2genotype. Moreover, molecular monitoring is only sporadically performed in CML patients with atypicalfusion transcripts due to lack of consensus approaches or standardization. Read More

    PAX5-Negative Classical Hodgkin Lymphoma: A Case Report of a Rare Entity and Review of the Literature.
    Case Rep Hematol 2017 4;2017:7531729. Epub 2017 Oct 4.
    Department of Pathology and Laboratory Medicine, University of California, Davis, Davis, CA, USA.
    Classical Hodgkin lymphoma (CHL) is recognized as a B-cell neoplasm arising from germinal center or postgerminal center B-cells. The hallmark of CHL is the presence of CD30 (+) Hodgkin and Reed-Sternberg (HRS) cells with dim expression of PAX5. Nearly all of the HRS cells are positive for PAX5. Read More

    HbS-Sicilian ()-Thalassemia: A Rare Variant of Sickle Cell.
    Case Rep Hematol 2017 17;2017:9265396. Epub 2017 Sep 17.
    Cleveland Clinic Lerner College of Medicine (CCLCM), Case Western University, 9500 Euclid Avenue, Cleveland, OH 44195, USA.
    Sickle cell disease (SCD) is caused by a mutation in the sixth codon of the-globin gene on chromosome 11, which leads to a single amino acid substitution (glutamine to valine). Sickle-()-thalassemia is a rare variant of sickle cell disease (delta-beta thalassemia occurring in association with sickle hemoglobin, HbS), sparsely reported in literature, and has been associated with symptomatology necessitating careful monitoring and follow-up. We describe a patient who presented with a newborn screen reported as "FS" and a negative family history for sickle cell disease and sickle cell trait. Read More

    Heterozygous Hemoglobin Sherwood Forest Causing Polycythemia.
    Case Rep Hematol 2017 28;2017:8174207. Epub 2017 Sep 28.
    Department of Pathology and Laboratory Medicine, Brown University Alpert Medical School, Providence, RI, USA.
    Hemoglobin (Hb) Sherwood Forest is a rare high-affinity hemoglobin first described in 1977, arising from an Arg to Thr substitution at codon 104 of the beta chain. This hemoglobin variant has been identified in few individuals and has been associated with a compensatory erythrocytosis in the homozygous state. Prior scarce case reports have noted that heterozygotes for this variant are phenotypically normal. Read More

    Plasmablastic Lymphoma: Case Report of Prolonged Survival of an Advanced Human Immunodeficiency Patient and Literature Review.
    Case Rep Hematol 2017 24;2017:9561013. Epub 2017 Sep 24.
    Division of Hematology Oncology, George Washington University School of Medicine and Health Sciences, Washington, DC, USA.
    . Plasmablastic lymphoma (PBL) is a rare and highly aggressive variant of diffuse large B cell lymphoma with median survival of advanced stage patients varying between 6 and 15 months in previous reports. We report here a human immunodeficiency virus-infected patient surviving over 12 years following treatment for advanced PBL with EPOCH chemotherapy and intrathecal therapy. Read More

    Polycythaemia Secondary to Hormone Replacement Therapy with Tibolone.
    Case Rep Hematol 2017 27;2017:3476349. Epub 2017 Sep 27.
    Haematology Department, The Canberra Hospital, Canberra, ACT, Australia.
    We present the case report of a patient with severe polycythaemia associated with tibolone. In our 65-year-old postmenopausal patient who initially presented with haemoglobin 203 g/L [115-160] and haematocrit 0.63 [0. Read More

    Posttransplant Lymphoproliferative Disorder in a Patient with Worsening Ascites after Liver Transplantation.
    Case Rep Hematol 2017 11;2017:7247438. Epub 2017 Sep 11.
    McGovern Medical School, Department of Gastroenterology, Transplant and Advanced Hepatology, The University of Texas Health Science Center at Houston, 6431 Fannin St., Suite MSB 1.134, Houston, TX 77030, USA.
    Posttransplant lymphoproliferative disorder (PTLD) is a spectrum of diseases that involves abnormal lymphoid and/or plasmacytic proliferation in patients with solid organ or hematopoietic cell transplantation. It is a condition with a low incidence of 3.5-4. Read More

    Primary Cutaneous Follicle Centre Lymphoma with Hodgkin and Reed-Sternberg Like Cells: A Case Report and Review of the Literature.
    Case Rep Hematol 2017 26;2017:9549428. Epub 2017 Sep 26.
    Department of Pathology and Laboratory Medicine, Warren Alpert Medical School of Brown University, Rhode Island Hospital, Providence, RI, USA.
    An elderly woman with a complex medical history presented with a left forearm mass that slowly developed for several months. The excisional biopsy of this skin mass was remarkable for involvement by a follicle centre cell derived lymphoma with a nodular and diffuse pattern associated with a subset of scattered Hodgkin and Reed-Sternberg like cells. Fluorescence in situ hybridization studies did not detect the presence of IgH-bcl2 fusion transcript, and molecular studies were negative for immunoglobulin heavy chain gene rearrangements and EBV DNA sequences. Read More

    A Case of Rituximab-Induced Necrotizing Fasciitis and a Review of the Literature.
    Case Rep Hematol 2017 26;2017:6971027. Epub 2017 Sep 26.
    Department of Medicine, Reading Hospital, West Reading, PA, USA.
    Necrotizing fasciitis is a fulminant soft tissue infection characterized by rapid progression and high mortality. Rituximab is a generally well-tolerated immunosuppresive medication used for B-cell malignancies and some rheumatological disorders. We report a case of a 69-year-old male with chronic lymphocytic leukemia who suffered necrotizing fasciitis of his left lower extremity secondary to7 weeks after treatment with rituximab. Read More

    An Unsuspected Finding of t(9;22): A Rare Case of Philadelphia Chromosome-Positive B-Lymphoblastic Lymphoma.
    Case Rep Hematol 2017 18;2017:2413587. Epub 2017 Sep 18.
    Department of Leukemia, UT MD Anderson Cancer Center, Houston, TX, USA.
    While rare, cases of isolated extramedullary disease of B-cell Lymphoblastic Lymphoma (B-LBL) without morphologic bone marrow involvement have been described. In this report, we illustrate the case of an elderly gentleman who presented with isolated testicular and vertebral LBL involvement but had no morphologic bone marrow involvement. The initial plan of treatment was to treat along the lines of Philadelphia negative B-ALL/LBL. Read More

    Cutaneous Vasculitis: An Unusual Presentation of a Biclonal Nodal Plasma Cell Dyscrasia.
    Case Rep Hematol 2017 13;2017:8152610. Epub 2017 Sep 13.
    Haematology Department, University Hospital Waterford, Regional Cancer Center South East, University College Cork, Cork, Ireland.
    We describe an unusual case of a biclonal nodal plasma cell dyscrasia, presenting with a vasculitic rash, end-organ damage, and cytopenias. Serum protein electrophoresis demonstrated a biclonal kappa-restricted paraprotein, with a negative skeletal survey and no bone marrow disease. Fluorodeoxyglucose-PET-CT (FDG-PET-CT) revealed nodal involvement, which was not appreciable clinically, and facilitated biopsy, confirming the diagnosis of a nodal plasmacytoma. Read More

    Immune-Mediated Autonomic Neuropathies following Allogeneic Stem Cell Transplantation in Acute Myeloid Leukemia.
    Case Rep Hematol 2017 27;2017:6803804. Epub 2017 Aug 27.
    Division of Hematology, Department of Medicine, Mayo Clinic, Rochester, MN, USA.
    Background/aims: Autonomic dysfunction (AD) after allogeneic stem cell transplant (SCT) is a rare occurrence and likely immune-mediated in etiology. There is limited literature on this topic and hence, we wish to briefly describe management of two cases at our institution and their outcomes.

    Methods: We retrospectively identified two patients with immune-mediated AD after SCT from our database. Read More

    Acute Unilateral Renal Infarction in the Setting of an Inherited Thrombophilia and Atrial Septal Defect.
    Case Rep Hematol 2017 27;2017:3159363. Epub 2017 Aug 27.
    Department of Medicine, Division of Hematology and Thromboembolism and Thrombosis and Atherosclerosis Research Institute, McMaster University, Hamilton, ON, Canada.
    We present a case of renal infarction in a 43-year-old female with history of stroke at age 14. She was found to be heterozygous for the prothrombin G20210A gene mutation. Loop monitoring revealed no atrial fibrillation. Read More

    Ponatinib as a Valid Alternative Strategy in Patients with Blast Crisis-Chronic Myeloid Leukemia Not Eligible for Allogeneic Stem Cells Transplantation and/or Conventional Chemotherapy: Report of a Case.
    Case Rep Hematol 2017 14;2017:6167345. Epub 2017 Aug 14.
    Hematology Division, IRCCS Ca' Granda-Maggiore Policlinico Hospital Foundation and University of Milan, Milan, Italy.
    Currently, imatinib and dasatinib are the only tyrosine-kinase inhibitors approved in the US and Europe for the treatment of blast crisis of chronic myeloid leukemia (BC-CML) at diagnosis, while ponatinib is the only inhibitor used in patients bearing T315I mutation. Here we report the case of a 61-year-old man diagnosed with B-cell lymphoid BC-CML, initially treated with imatinib 800 mg day and then with dasatinib 140 mg day because of intolerance. A complete cytogenetic response (CCyR) was achieved at three months; however, three months later a relapse was observed, and the T315I mutation was detected. Read More

    High-Grade B-Cell Neoplasm with Surface Light Chain Restriction and Tdt Coexpression Evolved in a-Rearranged Diffuse Large B-Cell Lymphoma: A Dilemma in Classification.
    Case Rep Hematol 2017 13;2017:6891957. Epub 2017 Aug 13.
    Department of Hematology and Medical Oncology, National Center for Cancer Care and Research, Hamad Medical Corporation, Doha, Qatar.
    According to World Health Organization (WHO) classification (2008), B-cell neoplasms are classified into precursor B-cell or a mature B-cell phenotype and this classification was also kept in the latest WHO revision (2016). We are reporting a male patient in his fifties, with tonsillar swelling diagnosed as diffuse large B-cell lymphoma (DLBCL), germinal center. He received 6 cycles of RCHOP and showed complete metabolic response. Read More

    Decreased Rivaroxaban Levels in a Patient with Cerebral Vein Thrombosis Receiving Phenytoin.
    Case Rep Hematol 2017 10;2017:4760612. Epub 2017 Aug 10.
    Vascular Medicine and Thrombosis Service, Hospital Privado Universitario de Cordoba, Cordoba, Argentina.
    Combined use of antiepileptic drugs and anticoagulants is common. We describe the first case documenting laboratory interaction between rivaroxaban and phenytoin. A 48-year-old woman was admitted to our hospital due to cerebral venous thrombosis, bilateral pulmonary embolism, and deep vein thrombosis. Read More

    Bone Marrow-Liver-Spleen Type of Large B-Cell Lymphoma Associated with Hemophagocytic Syndrome: A Rare Aggressive Extranodal Lymphoma.
    Case Rep Hematol 2017 1;2017:8496978. Epub 2017 Aug 1.
    Division of Hematopathology, Department of Pathology and Laboratory Medicine, University of Miami and Sylvester Comprehensive Cancer Center, Miami, FL, USA.
    Recently, an unusual subtype of large B-cell lymphoma (LBCL) with distinctive clinicopathologic features has been recognized; it is characterized by involvement of bone marrow with or without liver and/or spleen, but no lymph node or other extranodal sites, usually associated with fever, anemia, and hemophagocytic lymphohistiocytosis (HLH). Because of this distinctive clinical presentation, it has been designated "bone marrow-liver-spleen" (BLS) type of LBCL. To date there is only one series of 11 cases of BLS type of LBCL with detailed clinical, pathologic, and cytogenetic data. Read More

    Sequential Kinase Inhibition (Idelalisib/Ibrutinib) Induces Clinical Remission in B-Cell Prolymphocytic Leukemia Harboring a 17p Deletion.
    Case Rep Hematol 2017 27;2017:8563218. Epub 2017 Jul 27.
    Serviço de Hematologia, Centro Hospitalar de Vila Nova de Gaia/Espinho, Vila Nova Gaia, Portugal.
    B-cell prolymphocytic leukemia (B-PLL) is a rare lymphoid neoplasm with an aggressive clinical course. Treatment strategies for B-PLL remain to be established, and, until recently, alemtuzumab was the only effective therapeutic option in patients harboring 17p deletions. Herein, we describe, for the first time, a case of B-cell prolymphocytic leukemia harboring a 17p deletion in a 48-year-old man that was successfully treated sequentially with idelalisib-rituximab/ibrutinib followed by allogeneic hematopoietic stem cell transplant (allo-HSCT). Read More

    Spontaneous Complete Remission in a Patient with Acute Myeloid Leukemia and Severe Sepsis.
    Case Rep Hematol 2017 24;2017:9593750. Epub 2017 Jul 24.
    Department of Infectious Disease, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran.
    Without treatment, acute myeloid leukemia (AML) is almost always fatal. Spontaneous remission of AML is a rare phenomenon and usually with a short duration. The exact mechanisms are unknown. Read More

    Immune Thrombocytopenia and JAK2V617F Positive Essential Thrombocythemia: Literature Review and Case Report.
    Case Rep Hematol 2017 20;2017:3725089. Epub 2017 Jul 20.
    Department of Haematology, Blood Neoplasms and Bone Marrow Transplantation, Medical University of Wrocław, Wrocław, Poland.
    We present the case where immune thrombocytopenia (ITP) and essential thrombocythemia (ET) sequentially appeared in the space of twenty-one years of follow-up. Impaired platelet production is present in both diseases, but clinical presentation and treatment are different. On the basis of this case history a possible role of autoimmunity as a predisposing factor to myeloproliferation has been discussed. Read More

    Large Granular Lymphocytic Leukemia: A Report of Response to Rituximab.
    Case Rep Hematol 2017 18;2017:7506542. Epub 2017 Jul 18.
    Department of Hematology/Oncology, Staten Island University Hospital, 475 Seaview Avenue, Staten Island, NY 10305, USA.
    Large granular lymphocytic (LGL) leukemia is a rare form of low grade leukemia characterized by large cytotoxic T cells or natural killer cells on morphological examination. Immunosuppressive therapy is employed as first-line therapy. Treatment options in refractory cases include the anti-CD52 antibody alemtuzumab and purine analogues. Read More

    Ibrutinib Treatment of Mantle Cell Lymphoma Relapsing at Central Nervous System: A Case Report and Literature Review.
    Case Rep Hematol 2017 16;2017:9583257. Epub 2017 Jul 16.
    Hematology Unit, Papardo Hospital, c/da Papardo, 98158 Messina, Italy.
    Mantle cell lymphoma (MCL) accounts for about 5% of all lymphomas. Its clinical and histological features are heterogeneous. After a frequently good initial response, the disease generally and repeatedly relapses and finally the outcome is poor. Read More

    Incidental Discovery of Multiorgan Extramedullary Plasmacytomas in the Setting of Newly Diagnosed Multiple Myeloma and Delayed Hemolytic Transfusion Reaction.
    Case Rep Hematol 2017 6;2017:4531858. Epub 2017 Jul 6.
    Division of Hematology and Oncology, SUNY Downstate Medical Center, Brooklyn, NY 11203, USA.
    Extramedullary plasmacytomas (EMPs) are defined by the presence of clonal plasma cell proliferation outside of the bone marrow, portending an overall poor prognosis. This case highlights extramedullary plasmacytomas as an unusual presenting manifestation of multiple myeloma. Through incidental discovery during a delayed hemolytic transfusion reaction workup, EMPs were found in the liver, spleen, and possibly the lung. Read More

    An Atypical Presentation of Chronic Atrophic Gastritis: Hemolytic Anemia and Mesenteric Panniculitis.
    Case Rep Hematol 2017 3;2017:5498034. Epub 2017 Jul 3.
    Albert Einstein Medical Center, Philadelphia, PA, USA.
    Microangiopathic hemolytic anemia (MAHA) requires an aggressive approach since primary thrombotic microangiopathy syndromes such as thrombotic thrombocytopenic purpura (TTP) can progress rapidly to a fatal outcome. Differential diagnosis can be challenging even for an experienced hematologist. We present a case of a 52-year-old male who presented with symptoms of mesenteric panniculitis and showed signs of MAHA. Read More

    Prostatic-Like Syndrome in a Woman with Chronic Lymphocytic Leukemia: Sequential Kinase Inhibitor Therapy.
    Case Rep Hematol 2017 2;2017:3869020. Epub 2017 Jul 2.
    Department of Hematology, Hospital Universitario de Getafe, Madrid, Spain.
    Chronic lymphocytic leukemia (CLL) is an incurable lymphoproliferative disorder with a heterogeneous genetic and clinical course. Two kinase inhibitors, ibrutinib and idelalisib, have demonstrated achievement of complete and durable remissions in relapse/refractory genetically unselected CLL patients. We present a case of relapsed CLL with extensive disease and hourglass deformity of urinary bladder as a result of the compression of two extraperitoneal paravesical soft tissue bulky masses, with excellent response to sequential kinase inhibitor therapy. Read More

    Acquired von Willebrand Syndrome in IgM Monoclonal Gammopathy as the Presentation of Lymphoplasmacytic Lymphoma.
    Case Rep Hematol 2017 29;2017:9862620. Epub 2017 May 29.
    Department of Hematology and Oncology, Guthrie Clinic/Robert Packer Hospital, Sayre, PA, USA.
    Acquired von Willebrand syndrome (AVWS) is an increasingly recognized entity with numerous potential underlying etiologies. Most commonly implicated are lymphoproliferative, myeloproliferative, cardiovascular, and autoimmune disorders. Unlike inherited von Willebrand disease (vWD), AVWS tends to present at an older age and without a family history of vWD. Read More

    Systemic Amyloidosis and Cardiac Autonomic Neuropathy Associated with Waldenstrom's Macroglobulinemia.
    Case Rep Hematol 2017 13;2017:8795213. Epub 2017 Jun 13.
    Department of Internal Medicine, Monmouth Medical Center, 300 2nd Ave, Long Branch, NJ 07740, USA.
    A 73-year-old male with long-standing Waldenstrom's macroglobulinemia complicated with systemic amyloidosis presented with a witnessed syncopal episode. He had complaints of orthostatic dizziness and palpitations for few months. Orthostatic hypotension and peripheral neuropathy were demonstrated on physical examination. Read More

    Extensive Bone Marrow Necrosis: Initial Presentation in Sickle Cell Anemia-A Case Report and Review of the Literature.
    Case Rep Hematol 2017 13;2017:7185604. Epub 2017 Jun 13.
    Dammam Regional Laboratory and Blood Bank (DRL), Dammam, Saudi Arabia.
    Bone marrow necrosis (BMN) is a rare clinical entity that was first described in an autopsy of a sickle cell disease (SCD) patient and is defined as ill-defined necrotic cells in an amorphous eosinophilic background with preservation of cortical bone. The pathophysiology of BMN is not well known; however, occlusion of the bone marrow microcirculation with subsequent hypoxia and cell injury has been thought to be common underlying features. Malignancy has been identified to be the primary cause in 90% of the cases whereas SCD was found in only 2%. Read More

    Sustained Remission in Patients with Primary Immune Thrombocytopenia after Romiplostim Tapering and Discontinuation: A Case Series in Real Life Management in Spain.
    Case Rep Hematol 2017 11;2017:4109605. Epub 2017 Jun 11.
    Amgen S.A., Moll de Barcelona, Edifici Sud, Planta 7, 08039 Barcelona, Spain.
    Romiplostim, a thrombopoietin-receptor agonist (TPO-ra), is a highly effective option in primary immune thrombocytopenia (ITP), with 80-90% of patients achieving platelet responses after few weeks of treatment. The evidence showing remissions, that is, sustained platelet counts after romiplostim discontinuation, in patients with ITP refractory to immunosuppressive therapy is steadily increasing. However, there is a lack of guidelines or recommendations addressing how and when to taper romiplostim in clinical practice in patients maintaining elevated and stable platelet counts. Read More

    Vertebral Artery Thrombosis in Chronic Idiopathic Thrombocytopenic Purpura.
    Case Rep Hematol 2017 11;2017:3184346. Epub 2017 Jun 11.
    School of Medicine, University of Jordan, Amman, Jordan.
    Introduction: Immune thrombocytopenic purpura (ITP) is an autoimmune hematological disorder that causes decreased production and destruction of platelets leading to thrombocytopenia. Although thrombocytopenia usually causes hemorrhagic problems, thrombotic events like strokes, although rare, can still occur. Management of thrombotic events in patients with ITP differs from that of patients with normal platelet count function and count. Read More

    Dermatomyositis Associated with Myelofibrosis following Polycythemia Vera.
    Case Rep Hematol 2017 4;2017:9091612. Epub 2017 Jun 4.
    Department of Internal Medicine, West Virginia University Hospital, 1 Medical Center Dr., Morgantown, WV 26505, USA.
    Dermatomyositis (DM) is a unique inflammatory myopathy with clinical findings of proximal muscle weakness, characteristic rash, and elevated muscle enzymes. The association of DM and malignancy, most commonly adenocarcinoma, is well known. There have been few case reports of primary myelofibrosis associated with DM. Read More

    A Rare Case of Paraneoplastic Aortitis Associated with Chronic Myelomonocytic Leukemia.
    Case Rep Hematol 2017 25;2017:3091973. Epub 2017 May 25.
    Division of Rheumatology, Cooper University Hospital, Camden, NJ, USA.
    Aortitis is a broad term describing inflammation of the aorta. The most common causes of aortitis are the large-vessel vasculitides giant cell arteritis and Takayasu arteritis. Other etiologies include aortitis associated with other autoimmune disorders, infectious causes, and paraneoplastic and idiopathic cases. Read More

    Thrombotic Microangiopathy Secondary to Intravenous Abuse of Opana® ER.
    Case Rep Hematol 2017 18;2017:1623907. Epub 2017 May 18.
    Geisinger Medical Center, Danville, PA, USA.
    Opana ER (oxymorphone) is an opioid drug available throughout the United States, and intravenous abuse of the crushed oral formulation has been associated with drug-induced thrombotic microangiopathy. In this abstract, we describe two young patients who lived together and used Opana ER intravenously. Both presented with microangiopathic hemolytic anemia that mimicked thrombotic thrombocytopenic purpura (TTP). Read More

    Coexistence of Antiphospholipid Syndrome and Heparin-Induced Thrombocytopenia in a Patient with Recurrent Venous Thromboembolism.
    Case Rep Hematol 2017 26;2017:3423548. Epub 2017 Apr 26.
    Lehigh Valley Health Network, Departments of Hematology and Oncology and Medicine, Allentown, PA, USA.
    Heparin-induced thrombocytopenia (HIT) is a prothrombotic adverse drug reaction in which heparin forms complexes with platelet factor 4 forming neoantigens that are recognized by autoantibodies. Antiphospholipid syndrome (APS) is similar to HIT in that it is mediated by autoantibodies that are also prothrombotic. We present a case of rare coexistence of antiphospholipid antibody syndrome and heparin-induced thrombocytopenia. Read More

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