675 results match your criteria Case reports in hematology[Journal]


Prefibrotic Myelofibrosis Presenting with Multiple Cerebral Embolic Infarcts and the Rare W515S Mutation.

Case Rep Hematol 2020 19;2020:8375986. Epub 2020 Jun 19.

Department of Haematology, University Hospital Limerick, Limerick V94 F858, Ireland.

Acquired, activating mutations of W515 are recognised driver mutations of the myeloproliferative neoplasms (MPN), namely, essential thrombocythemia and primary myelofibrosis. The most common mutation at this codon is W515L with several other mutations also described at a lower frequency. Of these less common mutations, W515S has only been reported sporadically with limited information on clinicopathological associations. Read More

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http://dx.doi.org/10.1155/2020/8375986DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7322597PMC

Fatal Retroperitoneal Hematoma in a Patient Receiving Enoxaparin for Bilateral Pulmonary Emboli.

Case Rep Hematol 2020 29;2020:4805967. Epub 2020 May 29.

Department of Pulmonary and Critical Care, Baptist Memorial Hospital-Golden Triangle, Columbus, MS, USA.

Venous thromboembolism occurs when a deep vein thrombosis travels to the lungs and forms a pulmonary embolism. Low-molecular-weight heparins are a mainstay in the treatment and prevention of venous thromboembolism and should be initiated promptly due to substantial morbidity and mortality. A rare side effect of low-molecular-weight heparins is major bleeding, which also carries a significant morbidity and mortality rate. Read More

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http://dx.doi.org/10.1155/2020/4805967DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7275952PMC

Hereditary Hyperferritinemia-Cataract Syndrome in 3 Generations of a Family in East Tennessee.

Case Rep Hematol 2020 26;2020:2837573. Epub 2020 May 26.

Department of Medicine, Division of Hematology/Oncology, University of Tennessee Medical Center, Knoxville, TN, USA.

Hereditary hyperferritinemia and cataracts syndrome (HHCS) without iron overload is a syndrome first identified less than 3 decades ago. While investigators have dissected the gene where several responsible mutations reside, it remains a relatively unknown genetic disorder to clinicians. The result is often an expensive, invasive evaluation for iron overload, followed by a well-intended prescription for a series of phlebotomies that delivers morbidity instead of benefit. Read More

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http://dx.doi.org/10.1155/2020/2837573DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7271056PMC

Chronic Atrophic Gastritis with Negative Intrinsic Factor and Parietal Cell Antibody Presenting as a Severe Hemolytic Anemia.

Case Rep Hematol 2020 15;2020:8697493. Epub 2020 May 15.

Medical University of South Carolina, Department of Internal Medicine, Charleston, SC, USA.

A 28-year-old Caucasian male with Hashimoto's disease and vitiligo presented with two weeks of dizziness on exertion following pharyngitis which was treated with prednisone 40 mg by mouth once a day for five days. Initial workup revealed anemia, elevated lactate dehydrogenase (LDH), and low haptoglobin. He underwent workup for causes of hemolytic anemia which was remarkable for a peripheral blood smear with hypersegmented neutrophils and low vitamin B12 levels concerning for pernicious anemia. Read More

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http://dx.doi.org/10.1155/2020/8697493DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7245653PMC

Severe Aplastic Anemia Developed after Thymectomy: A Case Report and Literature Review.

Case Rep Hematol 2020 13;2020:7819321. Epub 2020 Jan 13.

Internal Medicine Service, Federal University of Pernambuco, Recife, PE, Brazil.

Thymus neoplasms are frequently related to paraneoplastic autoimmune manifestations. Its most common associations are myasthenia gravis and pure red cell aplasia. Aplastic anemia has been increasingly documented as an initial presentation of thymoma. Read More

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http://dx.doi.org/10.1155/2020/7819321DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7201839PMC
January 2020

Aggressive Disease Course of Multiple Myeloma with Concomitant ALK-Negative Anaplastic Large Cell Lymphoma: A Case Report with an Unusual Presentation.

Case Rep Hematol 2020 16;2020:6309736. Epub 2020 Jan 16.

Haematology Unit, Careggi University Hospital, Florence, Italy.

ALK-negative anaplastic large cell lymphoma is a rare T-cell neoplasm with an aggressive course requiring prompt diagnostic work-up and treatment. Few cases of concomitant multiple myeloma and T-cell neoplasm are described in the literature, mainly regarding primary cutaneous anaplastic large cell lymphoma. We present the case of a 65-year-old man, simultaneously diagnosed with ALK-negative anaplastic large cell lymphoma with extranodal localization in the gastrocnemius muscle (stage 1AE) and IgG lambda multiple myeloma (ISS 2, Durie-Salmon stage 3A). Read More

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http://dx.doi.org/10.1155/2020/6309736DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7201522PMC
January 2020

Prolonged Pediatric Extracorporeal Membrane Oxygenation Support with Cardiopulmonary Failure in Juvenile Myelomonocytic Leukemia.

Case Rep Hematol 2020 13;2020:5696380. Epub 2020 Jan 13.

Center for Congenital Heart Disease, Department of Cardiovascular Surgery, Inselspital University Hospital, Bern University, Bern, Switzerland.

We report a case of a child survival after extracorporeal membrane oxygenation (ECMO) support of 25 days for cardiopulmonary failure and septic shock in the context of juvenile myelomonocytic leukemia (JMML). ECMO support is still a matter of debate for the management of septic patients with malignancy. However, these patients are at increased risk for early death secondary to pulmonary complications due to leukostasis, direct pulmonary infiltration with WBC, and systemic inflammatory response syndrome following malignant cell lysis. Read More

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http://dx.doi.org/10.1155/2020/5696380DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7201439PMC
January 2020

Myeloid Sarcomas Causing Unilateral Cranial Nerve Palsies in a Patient with Relapsed Acute Myeloblastic Leukemia.

Case Rep Hematol 2020 13;2020:3749565. Epub 2020 Jan 13.

Department of Hematology and Oncology, Alton Memorial Hospital, Alton, IL, USA.

Myeloid sarcomas (MS) are a rare manifestation of myeloid malignancies and can often be misdiagnosed, leading to a delay in treatment. The objective of this clinical case is to highlight the challenges of the clinical presentation and to emphasize the importance of this manifestation ensuring timely diagnosis and therapy. Here, we present a 43-year-old man who was diagnosed with acute myeloblastic leukemia (AML) after being evaluated for unintentional weight loss, subcutaneous nodules, thrombocytopenia, and anemia. Read More

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http://dx.doi.org/10.1155/2020/3749565DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7201833PMC
January 2020

Spontaneous Spinal Epidural Hematoma in a Patient on Apixaban for Nonvalvular Atrial Fibrillation.

Case Rep Hematol 2020 14;2020:7419050. Epub 2020 Apr 14.

Detroit Medical Center Sinai Grace Hospital, Detroit, MI, USA.

Background: With the rise in the use of direct oral anticoagulants (DOACs), more hemorrhagic complications are being encountered. Since the first description of a case of spontaneous spinal epidural hematoma (SSEH) related to the utilization of DOACs in 2012, there have been few reports describing a similar association. However, no cases so far have reported an association between SSEHs and apixaban. Read More

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http://dx.doi.org/10.1155/2020/7419050DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7178514PMC

Two Consecutive Episodes of Severe Delayed Hemolytic Transfusion Reaction in a Sickle Cell Disease Patient.

Case Rep Hematol 2020 14;2020:2765012. Epub 2020 Apr 14.

Department of Haematology, Oslo University Hospital, Oslo, Norway.

Patients with sickle cell disease (SCD) suffer from anemia and painful vaso-occlusive crisis (VOC) and sometimes need blood transfusions. Delayed hemolytic transfusion reaction (DHTR) is a rare life-threatening complication observed in SCD and mimics VOC. We describe a female SCD patient undergoing three surgical procedures during which DHTR developed following the first two. Read More

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http://dx.doi.org/10.1155/2020/2765012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7180413PMC

Primary Bone Lymphoma: A Case Series and Review of Literature.

Case Rep Hematol 2020 10;2020:4254803. Epub 2020 Apr 10.

Department of Hematology and Oncology, Smilow Cancer Hospital at St. Francis, Hartford, CT, USA.

Primary bone lymphoma (PBL) is a subtype of lymphoma that exclusively affects skeletal tissue. Despite the relatively common involvement of skeletal structures as a manifestation of non-Hodgkin's lymphoma (NHL), primary and exclusive involvement of the skeletal system is rare. The prevalence of PBL is estimated to be 3-7% amongst primary bone tumors and less than 2% amongst all lymphomas in adults. Read More

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http://dx.doi.org/10.1155/2020/4254803DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7171650PMC

Reactivation of Epstein-Barr Virus Presenting as Massive Splenomegaly after Initiation of Golimumab Treatment.

Case Rep Hematol 2020 10;2020:3641813. Epub 2020 Apr 10.

Arkadi M. Rywlin Department of Pathology and Laboratory Medicine, Mount Sinai Medical Center, Miami Beach, FL 33140, USA.

Epstein-Barr virus infection is most commonly asymptomatic in the acute setting, where the end result of infection is the adoption of a viral latency phenotype. The virus can reactivate later in life leading to the abnormal proliferation of the infected B, T, or NK cells. Hereby, we report a 71-year-old female with seronegative rheumatoid arthritis who presented with massive splenomegaly, pancytopenia, and positivization of antibodies against double-stranded deoxyribonucleic acid (dsDNA) after initiation of the anti-tumor necrosis factor (TNF) golimumab. Read More

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http://dx.doi.org/10.1155/2020/3641813DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7171624PMC

CD7-Positive Diffuse Large B-Cell Lymphoma Presenting as an Intranasal Tumor.

Case Rep Hematol 2020 12;2020:1514729. Epub 2020 Apr 12.

Department of Hematology, Nephrology, and Rheumatology, Akita University Graduate School of Medicine, Akita, Japan.

We report a case of a 74-year-old man with a cluster of differentiation (CD) 7-positive diffuse large B-cell lymphoma (DLBCL) in the right nasal cavity. Flow cytometry analyses showed CD7 and CD20 positivity in tumor cells. The patient received 6 cycles of R-CHOP plus local radiation therapy because positron emission tomography-computed tomography after R-CHOP revealed an intranasal lesion. Read More

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http://dx.doi.org/10.1155/2020/1514729DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7174964PMC

Co-Amoxiclav Induced Immune Haemolytic Anaemia: A Case Report.

Case Rep Hematol 2020 31;2020:9841097. Epub 2020 Mar 31.

National Hospital of Sri Lanka, Colombo, Sri Lanka.

Drug-induced immune haemolytic anaemia (DIIHA) is extremely rare. We herein report a case of DIIHA due to co-amoxiclav. A 53-year-old male being treated for left-sided pyelonephritis with intravenous co-amoxiclav developed symptoms and signs of anaemia on the third day of treatment. Read More

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http://dx.doi.org/10.1155/2020/9841097DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7150724PMC

Ibrutinib-Associated Cardiac Tamponade with Concurrent Antiplatelet Therapy.

Case Rep Hematol 2020 27;2020:4282486. Epub 2020 Mar 27.

Baton Rouge General Internal Medicine Residency Program, Baton Rouge General Medical Center, Baton Rouge, LA, USA.

Ibrutinib is approved for the first-line treatment of chronic lymphocytic leukemia (CLL). A well-known side effect of ibrutinib therapy is increased bleeding risk, which ranges from mild mucocutaneous bleeding to rarely life-threatening hemorrhage. The increased bleeding tendency associated with ibrutinib is thought to be related to its effect on several platelet signaling pathways, which can be exacerbated in the setting of concurrent antiplatelet or anticoagulant therapy. Read More

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http://dx.doi.org/10.1155/2020/4282486DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7139853PMC

Orbital Mucosa-Associated Lymphoid Tissue Lymphoma and Primary Cutaneous Classical Hodgkin Lymphoma: A Rare Case Report and Review of the Literature.

Case Rep Hematol 2020 28;2020:1945058. Epub 2020 Mar 28.

Division of Hematology, Oncology and Cell Therapy, Rush University Medical Center, Chicago, IL, USA.

A 60-year-old woman was diagnosed with isolated mucosa-associated lymphoid tissue (MALT) lymphoma of the ocular adnexa and treated with two years of weekly rituximab for eight doses followed by rituximab maintenance. After nearly two years of maintenance therapy, she developed a tender, indurated mass on the left neck. Biopsy results were consistent with primary cutaneous classical Hodgkin lymphoma (PCCHL). Read More

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http://dx.doi.org/10.1155/2020/1945058DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7142340PMC

Patient-Initiated Discontinuation of Tyrosine Kinase Inhibitor for Chronic Myeloid Leukemia.

Case Rep Hematol 2020 23;2020:9571691. Epub 2020 Mar 23.

Department of Haematology, University Hospital Galway, Galway H91 YR71, Ireland.

The introduction of tyrosine kinase inhibitors (TKI) has revolutionised the management of patients with chronic myeloid leukemia (CML) over the last twenty years, but despite significant improvements in survival, patients exhibit long-term side effects that impact on quality of life. A major advance in CML management has been the ability to discontinue TKI therapy achieving a treatment-free remission (TFR), yet this option is only available to eligible patients who present with low-risk disease and who subsequently attain deep and sustained molecular responses. A case is described of a patient with CML who self-initiated stopping of TKI therapy when in a less than optimal molecular remission. Read More

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http://dx.doi.org/10.1155/2020/9571691DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7125505PMC

Immune Thrombocytopenic Purpura (ITP) as an Uncommon Extraintestinal Complication of Crohn's Disease: Case Vignette and Systematic Literature Review.

Case Rep Hematol 2020 26;2020:4785759. Epub 2020 Mar 26.

Harbor-UCLA Medical Center, Department of Medicine, Division of Hematology & Medical Oncology, Torrance, CA, USA.

While the association of immune thrombocytopenic purpura (ITP) and inflammatory bowel disease (IBD) has been described in a few case reports, management of ITP as an extraintestinal manifestation of Crohn's disease (CD) is less studied. There are approximately a dozen cases describing the management of patients dually diagnosed with CD/ITP. Previous reports postulated that the mechanism of ITP in CD was through the presence of circulating immune complexes in the serum and antigenic mimicry due to increased mucosal permeability in active colitis, versus increased mucosal production of TH1-type proinflammatory cytokines during CD flares, which may account for remission of ITP with surgery for CD. Read More

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http://dx.doi.org/10.1155/2020/4785759DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7136770PMC

A Sudden Onset of Severe Thrombocytopenia While Using Evolocumab.

Case Rep Hematol 2020 26;2020:3281626. Epub 2020 Mar 26.

Department of Endocrinology and Diabetes, Faculty of Medicine, Saitama Medical University, 38 Morohongo, Moroyama, Iruma, Saitama 350-0495, Japan.

A 72-year-old man with a 10-year history of coronary heart disease started evolocumab treatment once a month after developing excess myalgia due to therapy with a 3-hydroxy-methylglutaryl CoA reductase inhibitor. No side effects such as myalgia symptoms had been reported during the first 14 months of evolocumab treatment; however, he suddenly presented with acute severe thrombocytopenia following the 14th treatment. His platelet count continued to decrease to a nadir of 1,000/L. Read More

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http://dx.doi.org/10.1155/2020/3281626DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7136763PMC

Non-Nodal CD5-Negative Mantle Cell Lymphoma with Secondary TP53 Deletion.

Case Rep Hematol 2020 18;2020:9185432. Epub 2020 Mar 18.

Wake Forest Baptist Medical Center, Winston-Salem, NC, USA.

Mantle cell lymphoma is a non-Hodgkin lymphoproliferative neoplasm with several clinical and morphologic variants linked, primarily, through genetic derangement of the locus. Aberrant phenotypes have been described, though prognostic data in such cohorts are limited due to a paucity of cases. We report a case of mantle cell lymphoma with non-nodal clinical presentation, aberrant loss of CD5 expression, and concomitant cytogenetic deletion of 17p. Read More

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http://dx.doi.org/10.1155/2020/9185432DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7106885PMC

Surgery in a Patient with Haemophilia A and Lymphoma.

Case Rep Hematol 2020 18;2020:4852428. Epub 2020 Mar 18.

Fundación de la Hemofilia de Salta, Salta, Argentina.

An increased incidence of haematologic malignancies and other cancer types among patients with haemophilia compared with matched controls has been reported in several longitudinal studies. Tumours initially misdiagnosed as haematomas and conversely haematomas mistaken for tumours have been reported. Here, we describe the case of a 43-year-old man with severe haemophilia A and a diffuse large B-cell lymphoma, originally diagnosed as a haematoma, who underwent a splenectomy and several associated surgeries as part of his lymphoma treatment. Read More

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http://dx.doi.org/10.1155/2020/4852428DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7106912PMC

Myelodysplastic Syndrome with Transfusion Dependence Treated with Venetoclax.

Case Rep Hematol 2020 12;2020:9031067. Epub 2020 Mar 12.

University of Vermont Medical Center, Hematology and Medical Oncology, 89 Beaumont Ave., Burlington, VT 05405-0068, USA.

Myelodysplastic syndromes are characterized by ineffective hematopoiesis in one or more lineages of the bone marrow. They are a group of heterogeneous clonal stem cell malignancies with a high risk to progress to acute myeloid leukemia. Currently, there are no curative FDA-approved medications for myelodysplastic syndromes. Read More

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http://dx.doi.org/10.1155/2020/9031067DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7091525PMC

Arsenic Trioxide Treatment during Pregnancy for Acute Promyelocytic Leukemia in a 22-Year-Old Woman.

Case Rep Hematol 2020 11;2020:3686584. Epub 2020 Mar 11.

University Hospital of Besancon, Department of Hematology, Besançon F-25000, France.

Acute leukemia during pregnancy is rare (1 for 100000 pregnancies). The association of arsenic trioxide (ATO) and all-trans retinoic acid (ATRA) is known as the best therapy in standard-risk acute promyelocytic leukemia (APL). We describe the first case of a pregnancy with ATRA and ATO reported in the literature. Read More

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http://dx.doi.org/10.1155/2020/3686584DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7086430PMC

Atypical Hemolytic Uremic Syndrome following Acute Type A Aortic Dissection.

Case Rep Hematol 2020 3;2020:2467953. Epub 2020 Mar 3.

Department of Cardiovascular Surgery, Japan Community Healthcare Organization (JCHO) Kyushu Hospital, 1-8-1, Kishinoura, Yahatanishi-ku, Kitakyushu, Fukuoka 806-8501, Japan.

Atypical hemolytic uremic syndrome (aHUS) is a thrombotic microangiopathy (TMA)-related disease that manifests as a triad of microangiopathic hemolytic anemia, thrombocytopenia, and acute kidney injury (AKI) and is caused by uncontrolled activation of the complement system. We report the case of a 61-year-old woman with acute type A aortic dissection that subsequently developed into aHUS. The hematologic disorders underlying aHUS improved after treatment with the complement inhibitor eculizumab. Read More

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http://dx.doi.org/10.1155/2020/2467953DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7073471PMC

Addressing the Challenges to Diagnose Neonatal Hemolytic Anemia's Aetiologies in Low Ressources Countries: A Case Report.

Case Rep Hematol 2020 26;2020:3247127. Epub 2020 Feb 26.

Department of laboratory, Brazzaville Teaching Hospital, 13 Avenue Auxence Ikonga, BP 32, Brazzaville, Congo.

. The diagnosis of neonatal hemolysis is an easy exercise. However, the diagnosis of its etiology can be very challenging especially in low ressources countries where laboratory capacities are limited. Read More

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http://dx.doi.org/10.1155/2020/3247127DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7061141PMC
February 2020

Severe Thrombocytosis in a Newborn with Subcutaneous Fat Necrosis and Maternal Chorioamnionitis.

Case Rep Hematol 2020 21;2020:5742394. Epub 2020 Feb 21.

Department of Pediatrics, University of Texas Medical Branch, Galveston, TX, USA.

Background: Subcutaneous fat necrosis (SFN) is a form of transient panniculitis that presents commonly in infants with a history of perinatal insult, particularly hypothermia. It is characterized by subcutaneous nodules and plaques that appear over bony prominences on cheeks, shoulders, buttock, and thighs. SFN is usually associated with various complications including hypercalcemia, thrombocytopenia, hypertriglyceridemia, and hyperglycemia. Read More

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http://dx.doi.org/10.1155/2020/5742394DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7056997PMC
February 2020

Use of KRD-PACE as Salvage Therapy in Aggressive, Relapsed/Bortezomib-Refractory Extramedullary Multiple Myeloma: A Report of Two Cases and Literature Review.

Case Rep Hematol 2020 18;2020:4360926. Epub 2020 Feb 18.

Department of Hematology-Oncology, Mayo Clinic Florida, Jacksonville, FL, USA.

Extramedullary multiple myeloma is defined by the presence of plasma cell infiltration outside of the bone marrow. It is associated with a poor prognosis and resistance to therapy and is often associated with high-risk cytogenetics. Aggressive relapsed and refractory extramedullary multiple myeloma is often treated with salvage infusional chemotherapy to achieve rapid disease control. Read More

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http://dx.doi.org/10.1155/2020/4360926DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7049436PMC
February 2020

: A Candidate Gene for Predisposition to "Blend Pedigrees"? A Case Report from the NEXT-Famly Clinical Trial.

Case Rep Hematol 2020 11;2020:2795656. Epub 2020 Jan 11.

Chair of Hematology, Unit of Blood Diseases and Stem Cell Transplantation, Department of Clinical and Experimental Sciences, University of Brescia, ASST Spedali Civili di Brescia, 25123 Brescia, Italy.

Background: The identification of germline mutations in familial leukemia predisposition genes by next generation sequencing is of pivotal importance. Lately, some "blend pedigrees" characterized by both solid and hematologic malignancies have been described. Some genes were recognized as related to this double predisposition, while the involvement of others is still a matter of debate. Read More

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http://dx.doi.org/10.1155/2020/2795656DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7057007PMC
January 2020

Infection in an Allogeneic Hematopoietic Stem Cell Transplant Patient Receiving Voriconazole Prophylaxis.

Case Rep Hematol 2020 12;2020:8124137. Epub 2020 Feb 12.

Department of Medicine, Division of Hematology and Oncology, Indiana University School of Medicine, Indianapolis, IN, USA.

infection is a rare complication in the allogeneic stem cell transplant patients. Minimal guidance exists on how to appropriately manage histoplasmosis in these patients. We report a patient who developed pneumonia while receiving voriconazole prophylaxis at a therapeutic trough level. Read More

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http://dx.doi.org/10.1155/2020/8124137DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7039042PMC
February 2020

A Curious Case of Pseudothrombocytopenia due to Agglutination.

Case Rep Hematol 2020 13;2020:6236350. Epub 2020 Feb 13.

Department of Medicine, Zucker School of Medicine at Hofstra/Northwell at Lenox Hill Hospital, 100 E 77th St., New York, NY 10075, USA.

Pseudothrombocytopenia (PTCP) is a laboratory phenomenon that can occur in hospitalized patients, with approximately 0.1 to 0.2% due to ethylenediaminetetraacetic acid (ETDA). Read More

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http://dx.doi.org/10.1155/2020/6236350DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7040393PMC
February 2020

Successful Treatment of Pediatric Refractory/Relapsed AML with KIR-Ligand-Mismatched Cord Blood Transplant after FLAG-IDA Reinduction Therapy with or without the GO Regimen.

Case Rep Hematol 2020 12;2020:1378056. Epub 2020 Feb 12.

Department of Pediatrics, Showa University Fujigaoka Hospital, Yokohama, Japan.

Prognosis in pediatric patients with refractory/relapsed acute myeloid leukemia (AML) is grim, and there is no standard treatment for such patients. Combined treatment with intensive chemotherapy and gemtuzumab ozogamicin (GO), a monoclonal anti-CD33 antibody conjugated with calicheamicin, is useful as reinduction therapy in refractory/relapsed AML. Here, we describe three cases of pediatric refractory/relapsed AML that were successfully managed with FLAG-IDA (fludarabine, cytarabine, granulocyte colony-stimulating factor, and idarubicin), with or without GO, as reinduction therapy before a KIR-ligand-mismatched cord blood transplant. Read More

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http://dx.doi.org/10.1155/2020/1378056DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7037524PMC
February 2020

Multiple Myeloma in a Young Female Presenting with Neurological Symptoms.

Case Rep Hematol 2020 13;2020:1375174. Epub 2020 Feb 13.

Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hematology-Oncology Department at North Shore University Hospital-Long Island Jewish Medical Center, 300 Community Dr, Manhasset, NY 11030, USA.

Background: Multiple myeloma is overall the 14 most common malignancy but is rarely seen in those younger than 35 years. Those in the younger age group have been shown to have a more aggressive course but reportedly have had similar responses to treatment compared to older cohorts. Extramedullary plasmacytomas are discrete soft tissue masses of neoplastic monoclonal plasma cells that often occur in patients with multiple myeloma. Read More

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http://dx.doi.org/10.1155/2020/1375174DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7040387PMC
February 2020

Recurrent Gastrointestinal Hemorrhage in Children with Philadelphia-Positive B-Cell Acute Lymphoblastic Leukemia Treated with Dasatinib: Case Reports.

Case Rep Hematol 2020 10;2020:5678210. Epub 2020 Feb 10.

Department of Hematology, Children's Hospital of Chongqing Medical University, Chongqing 400014, China.

Dasatinib, a second-line tyrosine kinase inhibitor (TKI), has been widely used in chronic myeloid leukemia (CML) and Philadelphia-positive B-cell acute lymphoblastic leukemia (Ph + B-ALL). Although dasatinib has been well tolerated, side effects including hemorrhage are not rare. Cases of bleeding disorders ultimately result in thrombocytopenia, but platelet aggregation dysfunction induced by dasatinib has also been demonstrated in Ph + B-ALL and CML patients. Read More

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http://dx.doi.org/10.1155/2020/5678210DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7035504PMC
February 2020

A Case Report with Severe Thrombocytopenia Induced by Axitinib.

Case Rep Hematol 2020 7;2020:7520783. Epub 2020 Feb 7.

Tulane Cancer Center, School of Medicine, Tulane University, New Orleans, LA, USA.

Axitinib is an oral, second-generation tyrosine kinase inhibitor that is selective for vascular endothelial growth factor receptors (VEGFR). This agent is approved as monotherapy or in combination with immune checkpoint inhibitors for the treatment of metastatic renal cell carcinoma. Axitinib is associated with a safety profile very similar to other anti-VEGFR inhibitors but usually with fewer hematologic adverse events, due to the selectivity for VEGF. Read More

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http://dx.doi.org/10.1155/2020/7520783DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7029294PMC
February 2020

Fatal Idiopathic Hyperammonemia after Induction Chemotherapy for Acute Myeloid Leukemia.

Case Rep Hematol 2020 8;2020:3136074. Epub 2020 Feb 8.

Department of Hematology, Cliniques St-Luc, Université Catholique de Louvain, 1200 Brussels, Belgium.

Idiopathic hyperammonemia is a rare but potentially fatal complication occurring in patients with acute leukemia or bone marrow transplantation. The role of some specific anticancer drugs may be discussed, but the etiology of hyperammonemia is often multifactorial. We report the case of a 40-year-old woman who developed fatal idiopathic hyperammonemia two weeks after induction chemotherapy with idarubicin-aracytine for acute myeloid leukemia. Read More

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http://dx.doi.org/10.1155/2020/3136074DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7031708PMC
February 2020

Persistent Increase in Serum Alkaline Phosphatase in a Patient with Monoclonal Gammopathy of Undefined Significance.

Authors:
I Ramasamy

Case Rep Hematol 2020 31;2020:8406971. Epub 2020 Jan 31.

Worcester Royal Hospital, Charles Hastings Way, Worcester WR41DD, UK.

We report the finding of alkaline phosphatase-immunoglobulin complex (macro-alkaline phosphatase (macro-ALP)) in a patient with persistently increased ALP activity. The identification of macro-ALP is important to rule out pathological causes of increased ALP activity and to avoid unnecessary diagnostic investigation. The patient was subsequently diagnosed with vitamin D deficiency, gallstone pancreatitis, and monoclonal gammopathy of undefined significance (MGUS). Read More

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http://dx.doi.org/10.1155/2020/8406971DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7013342PMC
January 2020

A Rare Case of Extracavitary Primary Effusion Lymphoma in the Bladder and Ureter.

Case Rep Hematol 2020 19;2020:6124325. Epub 2020 Jan 19.

Hematology & Medical Oncology, Queens Medical Associates, 176-60 Union Tpke # 360, Fresh Meadows, NY 11366, USA.

Primary effusion lymphoma (PEL) is a rare and very aggressive large B-cell lymphoma usually presenting as serous effusions without a tumor mass. It is universally associated with human herpesvirus type-8 (HHV-8) infection. It most commonly occurs in the body cavities and rarely develops as solid tumor masses in the wall of cavity and other organs, and it has been termed as extracavitary PEL. Read More

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http://dx.doi.org/10.1155/2020/6124325DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6995319PMC
January 2020

Pure Red Cell Aplasia with Del(20q) Sensitive for Immunosuppressive Treatment.

Case Rep Hematol 2020 20;2020:1262038. Epub 2020 Jan 20.

Section Hematology, Department of Medicine, Haukeland University Hospital, Bergen, Norway.

Pure red cell aplasia (PRCA) is a rare syndrome that only affects the erythroid lineage. It is defined by a normocytic, normochromic anemia with a marked reticulocytopenia and severe reduction or absence of erythroid precursors in the bone marrow. Treatment of primary, idiopathic PRCA is immunosuppressive therapy. Read More

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http://dx.doi.org/10.1155/2020/1262038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6995481PMC
January 2020

Aggressive Central Nervous System Relapse after Autologous Stem Cell Transplant in Multiple Myeloma: Case Reports and Literature Review.

Case Rep Hematol 2020 3;2020:8563098. Epub 2020 Jan 3.

Hematology Department, Centro Hospitalar São João, Porto, Portugal.

Extramedullary disease is an aggressive presentation at diagnosis and relapse for multiple myeloma (MM) patients. Central nervous system (CNS) is a very rare manifestation of the extramedullary disease, accounting for less than 1% of MM on diagnosis and relapse. Neurological symptoms are unspecific and usually attributed to other causes. Read More

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http://dx.doi.org/10.1155/2020/8563098DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6964715PMC
January 2020

An Unusual Initial Presentation of Diffuse Large B-Cell Lymphoma as Recurrent Syncope.

Case Rep Hematol 2019 26;2019:1082543. Epub 2019 Dec 26.

Department of Hematology-Oncology, Einstein Medical Center Philadelphia, Philadelphia, PA, USA.

We describe a rare presentation of diffuse large B-cell Lymphoma (DLBCL) with recurrent episodes of syncope. During the workup for syncope, the patient was incidentally found to have an extensive mass in the left thorax, which was later diagnosed as stage 2 bulky disease DLBCL. This is the rare case of lymphoma presenting as recurrent syncope without cardiac involvement. Read More

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http://dx.doi.org/10.1155/2019/1082543DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6948279PMC
December 2019

Central Nervous System Double Relapse of Acute Promyelocytic Leukemia and Acute Myelomonocytic Leukemia.

Case Rep Hematol 2019 17;2019:4907352. Epub 2019 Dec 17.

Division of Hematology/Oncology, University of Alabama at Birmingham, Birmingham, AL, USA.

Relapse of acute promyelocytic leukemia (APL) and non-M3-acute myeloid leukemia in the central nervous system (CNS) are rare events. Here, we describe a case of simultaneous relapses of APL and acute myelomonocytic leukemia on the CNS of a patient after allogeneic bone marrow transplant. This extremely unusual case highlights the difficulties that CNS leukemia relapses pose in the post-transplant setting. Read More

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http://dx.doi.org/10.1155/2019/4907352DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6935803PMC
December 2019

A Massive Extradural Hematoma in Sickle Cell Disease and the Importance of Rapid Neuroimaging.

Case Rep Hematol 2019 18;2019:1742472. Epub 2019 Dec 18.

Department of Haematology and Blood Transfusion, Muhimbili University of Health and Allied Sciences, Dar-es-Salaam, Tanzania.

Sickle cell disease (SCD) is an inherited hemoglobinopathy leading to several serious organ complications and early death. It is mostly found in equatorial countries like Tanzania. Extradural hematoma (EDH) is a rare, but serious complication to SCD and may have debilitating consequences. Read More

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http://dx.doi.org/10.1155/2019/1742472DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6935788PMC
December 2019

Association of Immune Thrombocytopenia and T-Lymphoblastic Lymphoma in a Pediatric Patient.

Case Rep Hematol 2019 17;2019:1425151. Epub 2019 Dec 17.

Carbone Cancer Center, University of Wisconsin, Madison, WI, USA.

Immune thrombocytopenia (ITP) is characterized by isolated thrombocytopenia of unclear etiology. We present a unique case of an 8-year-old girl with chronic ITP who was subsequently diagnosed with T-lymphoblastic lymphoma at age 11. The clinical course was complicated by the occurrence of nonepileptiform events with bizarre behavior changes following the administration of nelarabine and intrathecal and high-dose systemic methotrexate. Read More

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http://dx.doi.org/10.1155/2019/1425151DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6935784PMC
December 2019

Hodgkin Lymphoma Mimicking Inflammatory Breast Carcinoma: A Rare Case with Diagnostic Challenge and Novel Treatment.

Case Rep Hematol 2019 5;2019:9256807. Epub 2019 Dec 5.

Department of Hematology, Medical School, University of Thessaly, Viopolis, 41500 Larisa, Greece.

Extranodal Hodgkin lymphoma involving the breast is infrequent. Most cases reported in the literature were diagnosed by histology after lumpectomy. We present a Hodgkin lymphoma mimicking inflammatory breast carcinoma in a 57-year-old woman. Read More

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http://dx.doi.org/10.1155/2019/9256807DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6915144PMC
December 2019

Extramedullary Manifestations of Chronic Myelomonocytic Leukemia: Do We Treat like an Acute Myeloid Leukemia?

Case Rep Hematol 2019 30;2019:8360454. Epub 2019 Nov 30.

Mountain Medicine Society of Nepal, Kathmandu, Nepal.

Chronic myelomonocytic leukemia (CMML) is a relatively rare clonal hematologic disorder with features of myelodysplastic syndrome and myeloproliferative disease. Extramedullary leukemic involvement is rarely a presenting feature of CMML. As there are no clear guidelines in regard to the treatment of patients with extramedullary manifestations, its management is challenging. Read More

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http://dx.doi.org/10.1155/2019/8360454DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6914965PMC
November 2019

Immunotherapy- (Blinatumomab-) Related Lineage Switch of Rearranged B-Lymphoblastic Leukemia into Acute Myeloid Leukemia/Myeloid Sarcoma and Subsequently into B/Myeloid Mixed Phenotype Acute Leukemia.

Case Rep Hematol 2019 7;2019:7394619. Epub 2019 Dec 7.

Division of Laboratory Genetics and Genomics, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.

The presence of rearrangement in B-lymphoblastic leukemia (B-ALL) is an independent poor prognostic factor and has been associated with higher rate of treatment failure and higher risk of linage switch under therapy. Blinatumomab has shown promising therapeutic results in refractory or relapsed B-ALL; however, it has potential risk of inducing lineage switch, especially in rearranged B-ALL into acute myeloid leukemia and/or myeloid sarcoma. We report a 40-year-old female with -rearranged B-ALL that was refractory to conventional chemotherapy. Read More

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http://dx.doi.org/10.1155/2019/7394619DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6925828PMC
December 2019

Secondary Squamous Cell Carcinoma of the Tongue Complicated with Bronchiolitis Obliterans as a Manifestation of Graft-versus-Host Disease following Peripheral Blood Stem Cell Transplantation.

Case Rep Hematol 2019 23;2019:6015803. Epub 2019 Nov 23.

Department of Oral and Maxillofacial Surgery, Okazaki City Hospital, Okazaki, Japan.

Peripheral blood stem cell transplantation (PBSCT) has increasingly been used for hematologic cancer therapy, resulting in improved survival rates. However, risks include graft-versus-host disease (GVHD) and secondary solid tumors. Here, we describe a case of tongue squamous cell carcinoma (SCC) complicated by bronchiolitis obliterans (BO) following PBSCT. Read More

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http://dx.doi.org/10.1155/2019/6015803DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6914976PMC
November 2019

Case of Stroke from Cerebral Vasculitis following Carfilzomib, Lenalidomide, and Dexamethasone Therapy in a Patient with Relapsing Multiple Myeloma.

Case Rep Hematol 2019 23;2019:5180424. Epub 2019 Nov 23.

Department of Internal Medicine, Maimonides Medical Center, Brooklyn, NY, USA.

Lenalidomide, a synthetic derivation of thalidomide, in recent years, has been the backbone of multiple myeloma treatment leading to improved survival. Common adverse effects from lenalidomide-based regimens include hypertension, heart disease, and venous thromboembolism. Hence, thromboprophylaxis is recommended to reduce the risk of stroke. Read More

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http://dx.doi.org/10.1155/2019/5180424DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6907054PMC
November 2019

An Unusual Presentation of T-Cell Lymphoblastic Lymphoma with Isolated Renal Involvement.

Case Rep Hematol 2019 10;2019:2802141. Epub 2019 Dec 10.

Department of Pediatrics, SBÜ Van Education and Research Hospital, Van, Turkey.

The clinical presentation of Non-Hodgkin lymphoma (NHL) is frequently associated with the involvement of the abdomen and mediastinal lymphadenopathies, but rarely the kidney, ovaries, and testicles. Here, we report a rare case of T-cell lymphoblastic lymphoma (T-LBL) presenting with bilateral nephromegaly without acute renal failure (ARF) as the first manifestation. A 30-month-old boy was admitted to the department of pediatric nephrology exhibiting abdominal distension. Read More

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http://dx.doi.org/10.1155/2019/2802141DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6925800PMC
December 2019

The First Case of E-Cigarette-Induced Polycythemia.

Case Rep Hematol 2019 26;2019:2084325. Epub 2019 Nov 26.

Department of Hematology, Kobe City Medical Center West Hospital, 2-4, Ichiban-cho, Nagata-ku, Kobe City, Hyogo 653-0013, Japan.

A 71-year-old male smoker was referred to our hospital because of increased hemoglobin and hematocrit. At initial consultation, his hemoglobin and hematocrit levels were 21.8 g/dl and 64. Read More

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http://dx.doi.org/10.1155/2019/2084325DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6899299PMC
November 2019