3,230,900 results match your criteria Case reports in gastrointestinal medicine[Journal]


[Transcranial direct current stimulation (tDCS) for obsessive-compulsive disorder: A new treatment option?]

Fortschr Neurol Psychiatr 2018 Dec 11. Epub 2018 Dec 11.

Klinik und Poliklinik für Psychiatrie und Psychotherapie, Klinikum der Universität München.

More than 40 % of patients with obsessive-compulsive disorder (OCD) do not respond to established treatments despite advances in psychopharmacology and psychotherapy. Since a couple of years, non-invasive brain stimulation techniques gain importance in the treatment of psychiatric disorders. Transcranial direct current stimulation (tDCS) uses weak constant direct current to modulate neuronal activation and changes the function of neuronal networks. Read More

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December 2018

Psychiatric comorbidy in Ullrich-Turner syndrome.

Fortschr Neurol Psychiatr 2018 Dec 11. Epub 2018 Dec 11.

Ruhr-Universität Bochum, Psychiatrie.

Objective: Ullrich-Turner Syndrome (UTS; Turner Syndrome (TS)) is a X-chromosomal disorder, which is characterized by a variety and heterogenous clinical conditions. Although it is not typically associated with neuropsychiatric disorders, several case reports describe concomitant TS and neuropsychiatric abnormalities that may represent a pathogenetic link.

Methods: Based on the case representation of woman with TS and co-occurrent schizoaffective disorder we discuss possible relationships and current literature. Read More

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December 2018
2 Reads

Case Report: Unexpected Benefit of Echocardiography in Childhood Polyarteritis Nodosa.

Klin Padiatr 2018 Dec 11. Epub 2018 Dec 11.

General University Hospital, Paediatric Rheumatology and Autoinflammatory Diseases Unit, Praha, Czech Republic.

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December 2018

[Acute Motor Failure of the N. Peroneus Profundus Caused by a Cystic Tibiofibular Joint].

Z Orthop Unfall 2018 Dec 11. Epub 2018 Dec 11.

Orthopädie und Traumatologie, Bürgerspital Solothurn, Solothurn, Schweiz.

A ganglion cyst is rarely the cause of peripheral nerve compression. In the lower extremity, it is important to distinguish clinically the symptoms from a radiculopathy. In the literature, neural damage of the peroneal nerve due to a ganglion cyst has been described. Read More

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December 2018

Hemophagocytic Lymphohistiocytosis during the Postpartum Stage of Pregnancy: A Report of Eight Cases.

Acta Haematol 2018 Dec 7;141(1):55-60. Epub 2018 Dec 7.

Haemophagocytic lymphohistiocytosis (HLH) is a rare and severe clinical syndrome that can be classified as either primary or secondary. Secondary HLH can be triggered by a variety of diseases. Pregnancy-related HLH has already been observed clinically. Read More

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December 2018

Transoral Robotic Surgery (TORS) for Bilateral Eagle Syndrome.

ORL J Otorhinolaryngol Relat Spec 2018 Dec 11;81(1):36-40. Epub 2018 Dec 11.

Eagle syndrome is a rare and poorly understood clinical condition caused by an elongated or disfigured styloid process. The possible managements of Eagle syndrome include conservative medical treatment or surgical intervention. The surgical removal of the elongated styloid process may be efficiently achieved either by an intraoral or a transcervical approach. Read More

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December 2018
4 Reads

Comparison of Pure-Tone Average Methods for Estimation of Hearing Loss Caused by Environmental Exposure to Lead and Cadmium: Does the Pure-Tone Average Method Which Uses Low-Frequency Ranges Underestimate the Actual Hearing Loss Caused by Environmental Lead and Cadmium Exposure?

Audiol Neurootol 2018 Dec 11;23(5):259-269. Epub 2018 Dec 11.

BK21 PLUS Program in Embodiment: Health-Society Interaction, Department of Public Health Sciences, Graduate School, Korea University, Seoul, Republic of Korea.

Previous studies have reported that exposure to lead and cadmium can damage the inner ear receptor, which perceives high-frequency sounds. However, few studies have used the pure-tone average (PTA), including high-frequency ranges, for the estimation of hearing loss caused by lead and cadmium exposure. We estimated hearing loss using the PTA test, in low-frequency, speech frequency, and high-frequency ranges and compared the differences in the results using 3 PTA calculation methods. Read More

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December 2018

Gonadotropin- and Adrenocorticotropic Hormone-Independent Precocious Puberty of Gonadal Origin in a Patient with Adrenal Hypoplasia Congenita Due to DAX1 Gene Mutation - A Case Report and Review of the Literature: Implications for the Pathomechanism.

Horm Res Paediatr 2018 Dec 11:1-10. Epub 2018 Dec 11.

Division of Pediatric Endocrinology and Diabetes, Department of Pediatrics and Adolescent Medicine, University of Ulm, Ulm, Germany.

Background/aims: Mutations in the DAX1 gene cause X-linked adrenal hypoplasia congenita (AHC) classically associated with hypogonadotropic hypogonadism. Unexpectedly, precocious puberty (PP) has been reported in some cases, its mechanism remaining unclear.

Methods: We longitudinally studied a boy with AHC due to DAX1 gene mutation who developed peripheral PP at age 4. Read More

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December 2018

Blue Rubber Bleb Nevus Syndrome: A Possible Cause for Growth Retardation and Pubertal Delay.

Med Princ Pract 2018 Dec 10. Epub 2018 Dec 10.

Objective: To describe a rare case of Blue Rubber Bleb Nevus (BRBNS) with growth retardation and pubertal delay.

Clinical Presentation And Intervention: A 16-year-old boy with severe iron deficiency anemia was diagnosed with BRBNS, showing growth retardation and pubertal delay simultaneously. The patient was treated conservatively with intravenous iron therapy and his puberty advanced gradually. Read More

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December 2018

Comparing two high correlation models to test the mechanical stability of Americium-II.

J Phys Condens Matter 2018 Dec 11. Epub 2018 Dec 11.

Instituto de Fisica, Benemerita Universidad Autonoma de Puebla, 18 sur y av. San Claudio, CU, San Manuel, Puebla, Puebla, 72570, MEXICO.

In this work two high DFT correlation methodologies, the so called DFT+U (or GGA+U) implementation and the eece hybrid DFT functional (or one case of HYB-DFT), are tested to determine the mechanical properties of Americium-II. For each case, the numeric value of their principal parameter is chosen (U for the first case and α for the second one) once the crystalline structure meets all the mechanical stability conditions. The results show that there is a range of values of U and α in which both methodologies generate a stable (experimentally correct) non-magnetic ground state, reaching approximately the same numeric value of the set of elastic constants of the cubic structure. Read More

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December 2018
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The refractory epilepsy screening tool for Lennox-Gastaut syndrome (REST-LGS).

Epilepsy Behav 2018 Dec 8;90:148-153. Epub 2018 Dec 8.

Icahn School of Medicine at Mount Sinai Health Systems, 10 Union Square East, Suite 5G, New York, NY 10003, USA. Electronic address:

Background: The complex clinical presentation and progression of Lennox-Gastaut syndrome (LGS) can complicate the accurate diagnosis of this severe, lifelong, childhood-onset epilepsy, often resulting in suboptimal treatment. The Refractory Epilepsy Screening Tool for LGS (REST-LGS) was developed to improve the identification of patients with LGS.

Methods: Using the Modified Delphi Consensus, a group of experts developed and tested the REST-LGS Case Report Form (CRF) comprising 8 criteria (4 major, 4 minor) considered potentially indicative of LGS. Read More

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December 2018

Is antibody-mediated rejection in kidney transplant recipients a risk factor for developing cytomegalovirus or BK virus infection? Results from a case-control study.

J Clin Virol 2018 Dec 1;110:45-50. Epub 2018 Dec 1.

Infectious Diseases Department, Vall d'Hebron University Hospital, Barcelona, Spain; Departament of Medicine, Universitat Autònoma de Barcelona, Barcelona, Spain.

Background: Data are scarce on cytomegalovirus (CMV) and BK virus (BKV) infection after antibody-mediated rejection (ABMR).

Objectives: We hypothesized that the immunological response in patients with ABMR or the immune modulation associated with its treatment could predispose to CMV and BKV infection. Our objective was to investigate this hypothesis. Read More

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December 2018

Curators and sojourners in learning networks: Practices for transformation.

Authors:
Julie Risien

Eval Program Plann 2018 Dec 4;73:71-79. Epub 2018 Dec 4.

Center for Research on Lifelong STEM Learning, Oregon State University, 254 Gilbert Hall, Corvallis, OR, 97331, United States. Electronic address:

Networks are a promising mechanism for creating systemic change. Studies abound, but do not examine roles and practices to reveal the processes through which networks create transformative capacity. This participatory single case study provides a framework to examine structures, roles and practices. Read More

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December 2018

Occurrence and contamination of heavy metals in urban mangroves: A case study in Shenzhen, China.

Chemosphere 2018 Nov 27;219:165-173. Epub 2018 Nov 27.

Guangdong Neilingding Futian National Nature Reserve, Shenzhen, 518000, China.

Urban mangroves are affected by surrounding anthropogenic activities. Heavy metals in urban mangroves lack systematic evaluation, and their relationships with surrounding anthropogenic activities have not been explored with quantified data. In this study, urban mangroves with different urban functional zonings were selected in Shenzhen, South China, including: Shajing mangrove (SJM) and Xixiang mangrove (XXM) featured with industry district, Futian mangrove (FTM) and Baguang mangrove (BGM) featured with central business district and ecological preserve, respectively. Read More

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November 2018

Do concentrations of perfluoroalkylated acids (PFAAs) in isopods reflect concentrations in soil and songbirds? A study using a distance gradient from a fluorochemical plant.

Sci Total Environ 2018 Dec 7;657:111-123. Epub 2018 Dec 7.

Systemic Physiological and Ecotoxicologal Research (SPHERE), Department of Biology, University of Antwerp, Groenenborgerlaan 171, 2020 Antwerp, Belgium. Electronic address:

Perfluoroalkylated acids (PFAAs) are persistent chemicals that have been detected globally in the environment and in wildlife. Although it is known that PFAAs sorb to solid matrices, little is known on PFAA concentrations in soils. PFAA pollution has often been studied in aquatic invertebrates. Read More

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December 2018

Assessment of Postoperative Outcomes in Spinal Epidural Abscess Following Surgical Decompression.

Spine J 2018 Dec 8. Epub 2018 Dec 8.

Center for Spine Health, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, Ohio, 44195, USA; Department of Neurosurgery, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, Ohio, 44195, USA; Cleveland Clinic Lerner College of Medicine, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, Ohio, 44195, USA. Electronic address:

Background Context: A spinal epidural abscess (SEA) is a serious condition that may be managed with antibiotics alone or with decompressive surgery combined with antibiotics.

Purpose: The objectives of this study were to assess the clinical outcomes of SEA after surgical management and to identify the patient-level factors that are associated with outcomes following surgical decompression and removal of SEA.

Study Design/setting: Retrospective chart review analysis. Read More

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December 2018
6 Reads

Surgical Risk Stratification Based on Preoperative Risk Factors in Adult Spinal Deformity.

Spine J 2018 Dec 8. Epub 2018 Dec 8.

Department of Orthopedic Surgery, Keio University School of Medicine; Keio Spine Research Group. Electronic address:

Background Context: Corrective surgery for adult spinal deformity (ASD) improves health-related quality of life but has high complication rates. Predicting a patient's risk of perioperative and late postoperative complications is difficult, although several potential risk factors have been reported.

Purpose: To establish an accurate, ASD-specific model for predicting the risk of postoperative complications, based on baseline demographic, radiographic, and surgical invasiveness data in a retrospective case series. Read More

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December 2018
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Postoperative antiplatelet therapy in the treatment of complex basilar apex aneurysms implementing Hunterian ligation and extracranial-to-intracranial bypass: review of the literature with an illustrative case report.

World Neurosurg 2018 Dec 8. Epub 2018 Dec 8.

Neurorestoration Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA; Department of Neurological Surgery, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA. Electronic address:

Large, broad-based basilar artery (BA) apex aneurysms involving multiple arterial origins are complex lesions commonly not amenable to direct clipping or endovascular management. BA proximal (Hunterian) occlusion with extracranial-to-intracranial bypass is a supported strategy if one or both posterior communicating arteries are small. Hunterian ligation risks sudden aneurysm thrombosis and thromboembolism in the perforator rich BA apex. Read More

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December 2018

Distal Thrombectomy for Acute Anterior Circulation Stroke with Chronic Large Vessel Occlusion.

World Neurosurg 2018 Dec 8. Epub 2018 Dec 8.

Department of Neurology, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, 250014, Shandong, China. Electronic address:

Background: Endovascular therapy has been increasingly recommended for the treatment of acute ischemic stroke with large vessel occlusion of the anterior circulation. However, occlusions of the distal cerebral artery are not uncommon and may cause clinical deficits, especially when combined with ipsilateral chronic large vessel occlusion. Therefore, in this patient population, the recognition of chronic occlusion and recanalization of the distal occlusive artery might be of great value for flow compensation. Read More

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December 2018
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Case report of the successful use of Mirena levonorgestrel intrauterine system in a patient with didelphys uterus and obstructed hemivagina.

Authors:
King Cp Kives S

J Pediatr Adolesc Gynecol 2018 Dec 8. Epub 2018 Dec 8.

Section of Paediatric Gynaecology, Division of Endocrinology, Hospital for Sick Children, and the Department of Obstetrics and Gynecology, University of Toronto, 7435A-555 University Avenue, Toronto, Ontario, Canada, M5G 1X8.

Background: The Mirena levonorgestrel intrauterine system (IUS) is frequently used for menstrual suppression in adolescents with special needs. However, the presence of a uterine anomaly is generally considered a contraindication to IUS insertion, thereby excluding a potentially highly effective option for this patient population.

Case: A Mirena IUS was utilized in a medically and surgically complex special needs 14-year-old adolescent with a didelphys uterus and obstructed hemivagina. Read More

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December 2018
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Outbreak of measles genotype H1 in Northern Italy originated from a case imported from South-East Asia, 2017.

Clin Microbiol Infect 2018 Dec 8. Epub 2018 Dec 8.

UOS Virologia Molecolare, UOC Microbiologia e Virologia, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy; Dipartimento di Scienze Clinico-Chirurgiche, Diagnostiche e Pediatriche, Università degli Studi di Pavia, Pavia, Italy. Electronic address:

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December 2018

Treatment of chronic osteomyelitis with multi-dose oritavancin: a case series and literature review.

Int J Antimicrob Agents 2018 Dec 8. Epub 2018 Dec 8.

Downtown Dublin Wound Center, Meadows Regional Medical Center, Dublin, GA, 31021, USA.

Osteomyelitis remains difficult to treat, typically requiring a prolonged course of intravenous (IV) antibiotics. The optimal route and duration of antibiotics remains ill-defined due to limited prospective clinical trials. Oritavancin is a long acting, semisynthetic, lipoglycopeptide antibiotic with rapid, concentration-dependent bactericidal activity against many Gram-positive organisms. Read More

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December 2018

Explaining consumers' intentions towards purchasing green food in Qingdao, China: The amendment and extension of the theory of planned behavior.

Appetite 2018 Dec 8. Epub 2018 Dec 8.

Department of Organic Food Quality and Food Culture, Faculty of Organic Agricultural Sciences, University of Kassel, Nordbahnhofstrasse 1A, 37213, Witzenhausen, Germany.

This study aims to investigate consumers' green food purchase intentions using a survey conducted in Qingdao, Shandong Province, China. Based on the Theory of Planned Behavior (TPB), it models the influences of Chinese culture and consumer characteristics towards purchasing green food products. According to TPB, the behavioral intention is determined by attitude, subjective norms and perceived behavioral control, whereas subjective norms vary according to differences in cultural systems. Read More

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December 2018

Measuring the Impact of Academic Cancer Network Development on Clinical Integration, Quality of Care, and Patient Satisfaction.

J Oncol Pract 2018 Dec;14(12):e823-e833

Yale New Haven Hospital; Yale School of Medicine; Yale Cancer Center; Smilow Cancer Hospital; and Community Health Educators Group, New Haven, CT.

Purpose:: Many US academic centers have acquired community practices to expand their clinical care and research footprint. The objective of this assessment was to determine whether the acquisition and integration of community oncology practices by Yale/Smilow Cancer Hospital improved outcomes in quality of care, disease team integration, clinical trial accrual, and patient satisfaction at network practice sites.

Methods:: We evaluated quality of care by testing the hypothesis that core Quality Oncology Practice Initiative measures at network sites that were acquired in 2012 were significantly different after their 2016 integration into the network. Read More

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December 2018

Primary liver carcinoma with sarcomatous changes: Analysis of 10 cases.

Hepatol Res 2018 Dec 7. Epub 2018 Dec 7.

Department of Hepatology, Toranomon Hospital, Tokyo, Japan.

Background & Aim: Primary liver carcinoma with sarcomatous change is a rare malignancy associated with high aggressiveness and poor prognosis. However, the characteristics of these types of tumors are still unknown. The aim of this study was to assess the imaging features, prognostic significance, and clinicopathological characteristics of patients with these tumors. Read More

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December 2018
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Literature review of apheresis procedures performed perioperatively in cardiac surgery for ASFA category indications.

J Clin Apher 2018 Dec 8. Epub 2018 Dec 8.

Department of Clinical Hematology - Blood Bank and Hemostasis, Onassis Cardiac Surgery Center, Kallithea, Greece.

Background: Perioperative therapeutic plasma exchange in patients with cardiovascular diseases poses several challenges, including alterations in intravascular volume, serum electrolytes, the coagulation cascade, and drug pharmacokinetics.

Methods: This review article summarizes different indications of plasma exchange for patients requiring cardiac surgery based on reported case reports and case series.

Results: The most common reported indication is plasma exchange for the management of allosensitized cardiac transplant candidate patients in combination with immunosuppressive regimens, which increases the likelihood of obtaining a cross-match-negative allograft, improving post-transplant clinical outcome. Read More

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December 2018

The digitally replicated denture technique: A case report.

J Esthet Restor Dent 2018 Dec 11. Epub 2018 Dec 11.

ROE Dental Laboratory, Independence, Ohio.

Objective: Conventional complete denture protocols require several patient appointments with multiple laboratory procedures. There are multiple workflows incorporating digital technology that can expedite the process, whereas increasing predictability. The proposed digitally replicated denture technique (DRDT) demonstrates a predictable workflow for fabricating complete dentures for patients with existing dentures. Read More

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December 2018

Prehospital Double Sequential Defibrillation: A Matched Case-Control Study.

Acad Emerg Med 2018 Dec 10. Epub 2018 Dec 10.

Department of Emergency Health Sciences, University of Texas Health Science Center at San Antonio, San Antonio, TX, 78229, USA.

Study Objectives: The goal of our study is to determine if prehospital double sequential defibrillation (DSD) is associated with improved survival to hospital admission in the setting of refractory ventricular fibrillation/pulseless ventricular tachycardia (VF/pVT).

Methods: This project is a matched case-control study derived from prospectively collected Quality Assurance/Quality Improvement (QA/QI) data obtained from the San Antonio Fire Department out-of-hospital cardiac arrest database between JAN 2013 and DEC 2015. The cases were defined as out-of-hospital cardiac arrest (OHCA) patients with refractory VF/pVT that survived to hospital admission. Read More

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December 2018
2 Reads

Allergic contact dermatitis due to undecylenic acid in an antifungal nail solution.

Contact Dermatitis 2018 Dec 7. Epub 2018 Dec 7.

Department of Dermatology, Hospital General Universitario de Alicante. Instituto de Investigación Sanitaria y Biomédica de Alicante (ISABIAL-FISABIO Foundation), Alicante, Spain.

Undecylenic acid (CAS no. 112-38-9) has antifungal and antibacterial effects. For this reason, it is used along with imidazole antifungals. Read More

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December 2018

Quantifying Proliferative and Surface Marker Heterogeneity in Colony Founding Connective Tissue Progenitors and Their Progeny Using Time-Lapse Microscopy.

J Tissue Eng Regen Med 2018 Dec 7. Epub 2018 Dec 7.

Dept. of Biomedical Engineering, Cleveland Clinic, Cleveland, OH.

Connective tissue progenitors (CTPs) are defined as the heterogeneous population of tissue-resident stem and progenitor cells that are capable of proliferating and differentiating into connective tissue phenotypes. The prevalence and variation in clonal progeny of CTPs can be characterized using a colony formation assay. However, colony assays do not directly assess the characteristics of the colony founding CTP. Read More

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December 2018

Rote und juckende bilaterale supraorbitale Schwellungen.

J Dtsch Dermatol Ges 2018 Dec;16(12):1503-1506

Klinik für Dermatologie, Venerologie und Allergologie, Charité - Universitätsmedizin Berlin, Deutschland.

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December 2018

Trügerische Vesikel.

J Dtsch Dermatol Ges 2018 Dec;16(12):1499-1501

Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy.

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December 2018

Digital pathology is a practical alternative to on-site intra-operative frozen section diagnosis in thoracic surgery.

Histopathology 2018 Dec 11. Epub 2018 Dec 11.

Thoracic Surgery, Bristol Royal Infirmary, University Hospitals Bristol NHS Foundation Trust, Bristol, United Kingdom.

Introduction: Telepathology uses digitised image transfer to allow off-site reporting of histopathology slides. This technology could facilitate the centralisation of pathology services, which may improve their quality and cost-effectiveness. The benefits may be most apparent in frozen section reporting, where turnaround times are vital. Read More

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December 2018

Activity and pharmacology of homemade silver nanoparticles in refractory metastatic head and neck squamous cell cancer.

Head Neck 2018 Dec 11. Epub 2018 Dec 11.

Department of Internal Medicine, UT Southwestern Medical Center, Dallas, Texas.

Background: Silver nanoparticles (AgNP) show efficacy in cancer cell lines. We present the first in-human outcome of AgNP in a cancer patient.

Methods: Homemade AgNP solution is manufactured using online instructions by a 78-year old male. Read More

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December 2018

Serum cotinine, vitamin D exposure levels and dental caries experience in U.S. adolescents.

Community Dent Oral Epidemiol 2018 Dec 10. Epub 2018 Dec 10.

Oral Health Services Research Core, Philips Institute for Oral Health Research, School of Dentistry, Virginia Commonwealth University, Richmond, Virginia.

Introduction: Epidemiologic studies of risk and protective factors for poor oral health have mostly been among children and adults, seldom focusing on adolescents. The aims of this study were to examine whether serum cotinine, a marker of tobacco exposure, and serum vitamin D are independently associated with dental caries experience among adolescents.

Methods: Cross-sectional data from 2579 adolescent participants in the 2005-2008 National Health and Nutritional Examination Survey were analysed. Read More

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December 2018

Treatment-resistant PLA2R-negative membranous nephropathy responsive to low-density lipoprotein apheresis.

J Clin Apher 2018 Dec 10. Epub 2018 Dec 10.

Department of Transfusion Medicine, National Institutes of Health Clinical Center, Bethesda, Maryland.

Idiopathic membranous nephropathy is the most common cause of nephrotic syndrome in nondiabetic adults. The antibody most often implicated is the M-type phospholipase A2 receptor (PLA2R) antibody, found in >70% of primary membranous nephropathy cases. First-line therapy is immunosuppressive in nature, but for patients who are treatment-resistant there is a significant risk of end-stage renal disease and mortality. Read More

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December 2018

Early outcome of magnesium bioresorbable scaffold implantation in acute coronary syndrome-the initial report from the Magmaris-ACS registry.

Catheter Cardiovasc Interv 2018 Dec 10. Epub 2018 Dec 10.

Department of Cardiology, Poznan University of Medical Sciences, Poland.

Objectives: The Magmaris-ACS Registry is the first assessment of the Magmaris implantation in the acute coronary syndrome (ACS) population.

Background: Bioresorbable vascular scaffolds (BRS), the newest coronary stent technology, was developed to overcome the limitations of the metallic drug-eluting stents (DES). Current promising data of the Magmaris in patients with stable angina have encouraged to validate the second generation BRS in ACS indications. Read More

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December 2018

Management of persistent juvenile angiofibroma after endoscopic resection: Analysis of a single institution series of 74 patients.

Head Neck 2018 Dec 10. Epub 2018 Dec 10.

Unit of Otorhinolaryngology - Head and Neck Surgery, University of Brescia, Brescia, Italy.

Background: Management of persistent juvenile angiofibroma (pJA) after transnasal endoscopic resection is controversial. To better understand its behavior, optimize treatment, and minimize morbidity, we report our experience in pJA focusing on follow-up strategies and disease progression.

Methods: A retrospective review of clinical records of all JA cases treated with endoscopic surgery at the Unit of Otorhinolaryngology of the University of Brescia between January 1994 and October 2015 was performed. Read More

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December 2018
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Novel approach to improve progesterone hydroxylation selectivity by CYP106A2 via rational design of adrenodoxin binding.

FEBS J 2018 Dec 7. Epub 2018 Dec 7.

Department of Biochemistry, Saarland University, Campus B2.2, 66123, Saarbrücken, Germany.

Bacterial P450s have considerable potential for biotechnological applications. The P450, CYP106A2, from Bacillus megaterium ATCC 13368 converts progesterone to several hydroxylated products that are important precursors for pharmaceutical substances. As high yields of monohydroxylated products are required for biotechnological processes, improving this conversion is of considerable interest. Read More

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December 2018

Classic pseudoxanthoma elasticum in a girl with sickle cell disease.

Pediatr Dermatol 2018 Dec 9. Epub 2018 Dec 9.

Department of Dermatology and Pediatrics, Texas Children's Hospital, Baylor College of Medicine, Houston, Texas.

A pseudoxanthoma elasticum (PXE)-like phenotype develops in a subset of patients with inherited hemoglobinopathies. Although PXE tissue changes are thought to develop in the absence of ABCC6 mutations in patients with beta-thalassemia, ABCC6 mutations have not been well evaluated among sickle cell disease patients with PXE-like disease. To our knowledge, we describe the first patient with sickle cell disease, PXE skin findings, and two confirmed pathogenic ABCC6 mutations. Read More

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December 2018
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Case of purpuric drug eruption probably induced by panitumumab.

J Dermatol 2018 Dec 7. Epub 2018 Dec 7.

Department of Dermatology, The University of Tokyo Graduate School of Medicine, Tokyo, Japan.

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December 2018

Incidence and risk factors of preterm premature rupture of membranes in singleton pregnancies at Siriraj Hospital.

J Obstet Gynaecol Res 2018 Dec 11. Epub 2018 Dec 11.

Department of Obstetrics and Gynecology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.

Aim: To obtain the incidence of preterm premature rupture of membranes (PPROM) at Siriraj Hospital during 2012-2016 and to identify its possible risk factors in singleton pregnancies.

Methods: This study was a retrospective case-control study. The institutional ethical committee has approved the study. Read More

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December 2018

Talking about trauma in therapy: Perspectives from young people with post-traumatic stress symptoms and first episode psychosis.

Early Interv Psychiatry 2018 Dec 9. Epub 2018 Dec 9.

Orygen, The National Centre of Excellence in Youth Mental Health, Parkville, Victoria, Australia.

Aim: Despite recommendations from national guidelines, individuals with first episode psychosis (FEP) are currently unlikely to have the effects of their traumatic experiences assessed and treated within psychosis treatment. This may be due to the mismatch between the objectives of trauma-specific treatments (directly targeting post-traumatic stress symptoms by talking about the trauma) and trauma-informed care (limiting practices that may retraumatise clients). We aimed to gain an understanding of what it was like for young people to talk about trauma in FEP treatment, and how their experiences related to the broad conceptualisations of trauma-informed and trauma-specific treatment approaches. Read More

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December 2018

A high-throughput glutathione trapping assay with combined high sensitivity and specificity in high resolution mass spectrometry by applying product ion extraction and data-dependent neutral loss.

J Mass Spectrom 2018 Dec 10. Epub 2018 Dec 10.

Department of Drug Metabolism and Pharmacokinetics, Sanofi, 153 2nd Avenue, Waltham, MA, 02451, USA.

Reactive metabolites are thought to play a pivotal role in the pathogenesis of some drug induced liver injury (DILI) and idiosyncratic adverse drug reactions (IADRs), which is of concern to patient safety and has been a cause of drugs being withdrawn from the market place. To identify drugs with a lower propensity for causing DILI and /or IADRs, high-throughput assays to capture reactive metabolites are required in pharmaceutical industry for early drug discovery risk assessment. We describe the development of an assay to detect glutathione adducts with combined high sensitivity, enhanced specificity and rapid data analysis. Read More

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December 2018

A single institutional review of pediatric Bacillus spp. bloodstream infections demonstrates increased incidence among children with cancer.

Pediatr Blood Cancer 2018 Dec 11:e27568. Epub 2018 Dec 11.

Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston, Massachusetts.

Background: Bacillus species are known to cause severe infection in immunocompromised hosts. The incidence of Bacillus bloodstream infections and characteristics of infection among children with cancer or indication for hematopoietic cell transplant (HCT) is unknown.

Methods: We performed a retrospective medical record review of all cases of Bacillus bacteremia between January 1, 2005, and December 31, 2014, at Boston Children's Hospital. Read More

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December 2018

Expression of PD-L1 in tumor-associated nerves correlates with reduced CD8 tumor-associated lymphocytes and poor prognosis in prostate cancer.

Int J Cancer 2018 Dec 11. Epub 2018 Dec 11.

Department of Urology and Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, 02114, USA.

To investigate immune profile consisting of stromal PD-L1 expression, inhibitory or non-T-cell inflamed tumor microenvironment that may predict response to anti-PD-L1/PD-1 immunotherapy in prostate cancer, we validated the specificity of a PD-L1 monoclonal antibody (E1L3N) and identified PD-L1 specific expression in prostatic stromal nerve cells. PD-L1 expression was analyzed in 73 primary prostate cancers and 7 castration-resistant prostate cancers (CRPC) by IHC and resulting data from primary prostate cancers were correlated with tumor-associated lymphocytes (TALs), clinicopathological characteristics and clinical outcome. PD-L1 was expressed in the tumor cells in only one primary prostate cancer case and none of the CRPC. Read More

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December 2018

Adult type rhabdomyoma presenting as a parathyroid adenoma.

Head Neck 2018 Dec 10. Epub 2018 Dec 10.

Department of Pathology, University of Iowa Hospitals and Clinics, Iowa City, Iowa.

Background: Adult-type rhabdomyoma (ATR) is a rare mesenchymal tumor of skeletal muscle differentiation. Extracardiac ATR occurs most commonly in the head and neck, but do so in a heterogeneous fashion, arising at numerous different locations within this region.

Methods: At our institution, we encountered a patient who was diagnosed clinically with parathyroid adenoma based on signs and symptoms of hyperparathyroidism and suggestive radiologic findings. Read More

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December 2018

Cutaneous malignant melanoma of the oral cavity following skin graft reconstruction: Case report.

Head Neck 2018 Dec 7. Epub 2018 Dec 7.

Department of Radiation Oncology, University of Iowa Hospitals and Clinics, Iowa City, Iowa.

Background: Malignant melanomas on skin graft recipient sites are rare, with few cases reported in the literature.

Methods: We present a case report of a patient with recurrent cutaneous melanoma in the grafted anterolateral thigh flap of the tongue.

Results: A patient underwent hemiglossectomy with free flap reconstruction for squamous cell carcinoma of the tongue. Read More

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December 2018
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