541 results match your criteria Case reports in dermatology[Journal]


Malignant Melanoma Treated with Topical Imiquimod: A Bespoke Treatment That Spared the Amputation.

Case Rep Dermatol 2019 Jan-Apr;11(1):1-6. Epub 2019 Jan 10.

Department of Dermatology, The Princess Alexandra Hospital NHS Trust, Harlow, United Kingdom.

Surgical excision represents the primary treatment for malignant melanoma. On occasion, however, surgery may not be possible, and a different approach is required. Imiquimod is a Toll-like receptor 7 agonist involved in the activation of the innate immune system. Read More

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http://dx.doi.org/10.1159/000496052DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381895PMC
January 2019

Lichenoid Reaction Pattern with Pseudoepitheliomatous Hyperplasia - A Rare Tattoo Reaction: A Case Report and Review of the Literature.

Case Rep Dermatol 2018 Sep-Dec;10(3):268-273. Epub 2018 Dec 5.

Department of Dermatology, Indiana University School of Medicine, Indianapolis, Indiana, USA.

Pseudoepitheliomatous hyperplasia is a benign histologic reaction pattern that in rare cases can occur shortly after a tattooing procedure. We describe a case of pseudoepitheliomatous hyperplasia in two tattoos on the same patient 1 year after filling with the same batch of red ink. Read More

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http://dx.doi.org/10.1159/000495026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323364PMC
December 2018
1 Read

Delayed Diagnosis of Vulvar Crohn's Disease in a Patient with No Gastrointestinal Symptoms.

Case Rep Dermatol 2018 Sep-Dec;10(3):263-267. Epub 2018 Nov 28.

Skin Care Physicians of Georgia, Macon, Georgia, USA.

Though Crohn's disease primarily affects the gastrointestinal tract, cutaneous Crohn's disease of the vulva can occur in the absence of gastrointestinal symptoms, complicating the diagnosis. Once clinicians suspect cutaneous Crohn's disease, antibiotics and traditional immunosuppressants comprise initial treatment. Unfortunately, sometimes these therapies are not effective, or they provide only short-lived symptomatic improvement. Read More

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http://dx.doi.org/10.1159/000495000DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323403PMC
November 2018
12 Reads

Keloid Formation due to Repetitive Mammographies.

Case Rep Dermatol 2018 Sep-Dec;10(3):257-262. Epub 2018 Nov 28.

Department of General Surgery, Máxima Medical Center, Veldhoven, The Netherlands.

A keloid is the result of an abnormal wound healing response to a variety of skin injuries, characterized by a well-circumscribed, firm, irregular, mildly tender, and pink to purple hyperpigmented lump with a glossy surface. The present case reports on excessive formation of keloid due to repetitive mammographies causing symptomatic, cosmetically disturbing symptoms. Read More

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http://dx.doi.org/10.1159/000495020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323402PMC
November 2018
1 Read

Phototoxic Reaction Induced by Pazopanib.

Case Rep Dermatol 2018 Sep-Dec;10(3):251-256. Epub 2018 Nov 21.

Division of Dermatology, Department of Internal Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.

Multikinase inhibitors (MKIs) are a novel target therapy that offers promising long-term survival for patients with advanced-stage cancer. However, they cause a wide range of adverse reactions, skin and skin appendage being the most prevalent. Photosensitivity reactions are well-recognized effects from certain MKIs such as sunitinib and vandetanib. Read More

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http://dx.doi.org/10.1159/000494611DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276734PMC
November 2018
3 Reads

Efficacy and Safety of Intralesional Methotrexate in the Treatment of a Large Keratoacanthoma of the Dorsal Hand in a 99-Year-Old Woman.

Case Rep Dermatol 2018 Sep-Dec;10(3):247-250. Epub 2018 Nov 14.

Medical Department, Cantabria Labs Difa Cooper, Caronno Pertusella, Italy.

Several case reports and retrospective studies have demonstrated that intralesional methotrexate (MTX) could be a very effective and safe alternative treatment of keratoacanthoma (KA). Here, we report a rapid clinical efficacy of two intralesional MTX injections (total dose 40 mg) that were performed 1 week apart in the treatment of a large KA lesion of the dorsal hand in a 99-year-old woman. The lesion, with a 3-cm major axis diameter and a thickness of 2 cm with a central ulceration had rapidly appeared on the right dorsal hand. Read More

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http://dx.doi.org/10.1159/000494322DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276738PMC
November 2018
4 Reads

Allergic Contact Dermatitis and Autoeczematization to Proctosedyl® Cream and Proctomyxin® Cream.

Case Rep Dermatol 2018 Sep-Dec;10(3):238-246. Epub 2018 Oct 24.

Department of Dermatology, University of Ottawa, Ottawa, Ontario, Canada.

Proctosedyl® and Proctomyxin® are two commonly prescribed hemorrhoid therapies. Their topical application to the perianal region may be complicated by a local allergic contact dermatitis and subsequent autoeczematization reaction. We present three cases of an autoeczematization (ID) reaction to varying topical allergens found in Proctosedyl®/Proctomyxin®. Read More

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http://dx.doi.org/10.1159/000486475DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276736PMC
October 2018
4 Reads

Atypical Manifestation of Disseminated Sporotrichosis in an AIDS Patient.

Case Rep Dermatol 2018 Sep-Dec;10(3):231-237. Epub 2018 Oct 24.

Sector of Dermatology and Post-Graduation Course, HUCFF-UFRJ and School of Medicine, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.

Sporotrichosis is an infection caused by fungi of the complex. The clinical lymphocutaneous presentation corresponds to the great majority of cases. With the increased incidence of sporotrichosis in the State of Rio de Janeiro, Brazil, atypical clinical forms have been reported with increasing frequency, usually associated with immunosuppression. Read More

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https://www.karger.com/Article/FullText/493181
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http://dx.doi.org/10.1159/000493181DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276748PMC
October 2018
20 Reads

Anti-Centromere Antibody Positivity in a Patient with Generalized Morphea.

Case Rep Dermatol 2018 Sep-Dec;10(3):226-230. Epub 2018 Oct 18.

Department of Dermatology, Nara Medical University School of Medicine, Kashihara, Japan.

We report the case of a 45-year-old female with generalized morphea (GM), who exhibited positivity for the anti-centromere antibody (Ab). She frequently developed multiple sclerotic skin lesions, whose histological findings were compatible with morphea. She demonstrated favorable responses to topical and oral steroids. Read More

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https://www.karger.com/Article/FullText/493180
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http://dx.doi.org/10.1159/000493180DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276767PMC
October 2018
16 Reads

Case Study of Onychomycosis Patients Treated with 1,064-nm Nd:YAG Laser.

Case Rep Dermatol 2018 May-Aug;10(2):216-225. Epub 2018 Aug 31.

Centro de Ciências da Saúde, Universidade Federal do Espírito Santo, Vitória, Brazil.

Onychomycosis is the most frequent nail disease, with an estimated prevalence of 2-8%. Current treatment strategies include the use of oral and topical antifungals, despite low cure rates following these treatments. The objectives of this study were to assess the therapeutic response of patients with onychomycosis to 1,064-nm Nd:YAG laser treatment, the clinical evaluation method available for this therapy, and the possible side effects of this treatment. Read More

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http://dx.doi.org/10.1159/000492526DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6167730PMC
August 2018
16 Reads

A Case of Primary Cutaneous Basal Cell Carcinosarcoma.

Case Rep Dermatol 2018 May-Aug;10(2):208-215. Epub 2018 Aug 28.

Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai, Japan.

A 94-year-old man consulted our hospital due to a rapidly growing tumor on the left cheek. The histological diagnosis of the tumor was basal cell carcinosarcoma, which was composed of intermingled epithelial and mesenchymal components. The former was basal cell carcinoma, while the latter was spindle cell sarcoma. Read More

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http://dx.doi.org/10.1159/000492525DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6167722PMC
August 2018
2 Reads

Recurrent Granuloma Gluteale Infantum Secondary to Fecal Overflow Incontinence.

Case Rep Dermatol 2018 May-Aug;10(2):203-207. Epub 2018 Aug 23.

University of North Texas Health Science Center, Fort Worth, Texas, USA.

Granuloma gluteale infantum is a rare pediatric dermatological disorder of uncertain etiology. Suggested causes include fluorinated corticosteroids, , and irritant contact dermatitis. We present the case of a 3-year-old boy with recurrent episodes of granuloma gluteale infantum which resolved with treatment of his fecal overflow incontinence. Read More

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http://dx.doi.org/10.1159/000492270DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6167654PMC
August 2018
8 Reads

Atezolizumab-Induced Stevens-Johnson Syndrome in a Patient with Non-Small Cell Lung Carcinoma.

Case Rep Dermatol 2018 May-Aug;10(2):198-202. Epub 2018 Aug 9.

Division of Dermatology, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.

Atezolizumab is a humanized anti-PD-L1 immune checkpoint antibody that is currently used in many kinds of advanced carcinoma including metastatic non-small cell lung cancer. The cutaneous side effect profile reported only 20$ of the patients which had only mild maculopapular rash that required no treatment. There is no case report of anti-PD-L1 antibody-induced Stevens-Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN) eruptions. Read More

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http://dx.doi.org/10.1159/000492172DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6120418PMC
August 2018
5 Reads

Psoriasis Vulgaris Exacerbation during Treatment with a PD-1 Checkpoint Inhibitor: Case Report and Literature Review.

Case Rep Dermatol 2018 May-Aug;10(2):190-197. Epub 2018 Aug 9.

Department of Dermatology, Ghent University Hospital, Ghent, Belgium.

Objective: The incidence of immune-related adverse events is growing as the use of checkpoint inhibitors is exponentially increasing. Cutaneous adverse events are among the most frequent immune-related adverse events. The purpose of this case report and literature review is to highlight psoriasis as a potential adverse event with need for early recognition. Read More

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http://dx.doi.org/10.1159/000491572DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6120403PMC
August 2018
2 Reads

Low Back Pain in Hidradenitis Suppurativa: A Diagnosis Not to Miss!

Case Rep Dermatol 2018 May-Aug;10(2):187-189. Epub 2018 Jul 12.

Dermatology Department, Erasme Hospital, Université Libre de Bruxelles, ULB, Brussels, Belgium.

We report the case of a patient suffering from hidradenitis suppurativa since puberty and complaining of chronic low back pain associated to altered sensitivity and muscular weakness in the right leg. A diagnosis of lumbosciatica was confirmed. Symptoms were not relieved after the use of nonsteroidal anti-inflammatory drugs and analgesics. Read More

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http://dx.doi.org/10.1159/000490880DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6103332PMC
July 2018
22 Reads

Aplasia Cutis Congenita: A Case Report.

Case Rep Dermatol 2018 May-Aug;10(2):182-186. Epub 2018 Jul 5.

Consultant Dermatologist, National Guard Hospital, King Abdul Aziz Medical City, Jeddah, Saudi Arabia.

Background: Aplasia cutis congenita is characterized by congenital focal absence of skin in a newborn.

Case Report: A 45-day-old boy presented to the outpatient clinic of dermatology at King Abdul Aziz Medical City, Jeddah, Saudi Arabia, with a flat scalp lesion on the space of the anterior fontanel. There was a positive family history of such condition in his older brother's scalp, which resolved spontaneously within 3 weeks after labor, without any medical intervention. Read More

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http://dx.doi.org/10.1159/000490786DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6062690PMC
July 2018
2 Reads

Churg-Strauss Syndrome or Eosinophilic Granulomatosis with Polyangiitis: Exuberant Classic Clinical Picture of a Rare Disease.

Case Rep Dermatol 2018 May-Aug;10(2):175-181. Epub 2018 Jun 29.

Sector of Dermatology and Post-Graduation Course - University Hospital and School of Medicine, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.

The authors present a classic case of Churg-Strauss syndrome with an exuberant clinical picture in a 34-year-old woman. She showed the following diagnostic criteria: asthma, polyneuropathy, rhinopathy, marked eosinophilia, positive p-ANCA with a perinuclear pattern, and skin histopathology results suggestive of vasculitis with eosinophils. There was a good response to prednisone, dexamethasone pulse therapy, and cyclophosphamide. Read More

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http://dx.doi.org/10.1159/000489162DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6062663PMC
June 2018
6 Reads

Widely Spread Unilateral Inflammatory Linear Verrucous Epidermal Nevus (ILVEN).

Case Rep Dermatol 2018 May-Aug;10(2):170-175. Epub 2018 Jun 14.

Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai, Japan.

Inflammatory linear verrucous epidermal nevus (ILVEN) is an epidermal nevus that clinically and histologically mimics linear psoriasis. The pathogenesis of psoriasis has been widely investigated, with recent studies focusing especially on targeting proinflammatory cytokines such as IL-17A, TNFα, IL-23, and IL-12, while little is known about ILVEN. Since the treatment for ILVEN varies widely from the administration of topical ointment for psoriasis to invasive methods such as carbon dioxide gas laser, the differential diagnosis between ILVEN and psoriasis is necessary. Read More

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http://dx.doi.org/10.1159/000489876DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6047550PMC
June 2018
22 Reads

Pseudolymphomatous Reaction to Red Tattoo Pigment.

Case Rep Dermatol 2018 May-Aug;10(2):162-168. Epub 2018 Jun 14.

Department of Dermatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.

Decorative tattooing is a procedure in which exogenous pigment and/or dye is introduced into the dermis with the aim of creating a permanent skin decoration. The increasing prevalence of tattooed individuals leads to more reported tattoo-related complications. Pseudolymphomatous reaction is a benign reactive proliferation of lymphocytes that may uncommonly occur secondary to tattooing. Read More

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http://dx.doi.org/10.1159/000489875DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6047551PMC
June 2018
3 Reads

A Case of Annular Elastolytic Giant Cell Granuloma Associated with Syphilis.

Case Rep Dermatol 2018 May-Aug;10(2):158-161. Epub 2018 Jun 5.

Department of Dermatopathology, Shanghai Skin Disease Hospital, Shanghai, China.

Annular elastolytic giant cell granuloma (AEGCG) is a rare granulomatous skin disease characterized by annular patches with slightly raised borders, hypopigmented and/or atrophic centers found mainly on sun-exposed skin. Histologically, it is characterized by phagocytosis of elastic fibers by multinucleated giant cells. The pathogenesis of the disease is unclear. Read More

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http://dx.doi.org/10.1159/000489910DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6047546PMC
June 2018
20 Reads

Bullous Pemphigoid as an Adverse Reaction to Pembrolizumab: Two Case Reports.

Case Rep Dermatol 2018 May-Aug;10(2):154-157. Epub 2018 Jun 5.

Department of Dermatology, Aarhus University Hospital, Aarhus, Denmark.

Checkpoint inhibitors are novel and promising treatment options for different types of cancer. Programmed cell death 1 (PD-1) inhibitors, such as pembrolizumab, have been shown to significantly raise the survival rates of disseminated malignant melanoma (MM). Autoimmune adverse reactions are very common in checkpoint inhibitors. Read More

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http://dx.doi.org/10.1159/000489661DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6047493PMC
June 2018
3 Reads

Methotrexate-Associated Lymphoproliferative Disorder: Dermoscopic Features.

Case Rep Dermatol 2018 May-Aug;10(2):149-153. Epub 2018 May 29.

Department of Dermatology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan.

Methotrexate-related lymphoproliferative disorder (MTX-LPD) is a rare disorder caused by long-term MTX therapy for autoimmune diseases. There has been no report of the dermoscopic features of MTX-LPD to date. A 64-year-old female presented with a slightly elevated indurated erythematous plaque with scales on her right thigh. Read More

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http://dx.doi.org/10.1159/000489694DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6006657PMC
May 2018
2 Reads

Bullous Pemphigoid Associated with Adalimumab Therapy in a Patient with Ulcerative Colitis.

Case Rep Dermatol 2018 May-Aug;10(2):145-148. Epub 2018 May 24.

Department of Dermatology, University Medical Center Regensburg, Regensburg, Germany.

Bullous pemphigoid (BP) is a blistering autoimmune disease mainly observed in elderly patients. Several triggers are known for this autoimmune disease and some drugs are known to be a cause of BP. However, there are only few case reports on the induction of BP under adalimumab therapy. Read More

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http://dx.doi.org/10.1159/000489163DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6006603PMC
May 2018
2 Reads

Nevus Lipomatosis Cutaneous Superficialis: A Single-Center Case Series of 5 Patients.

Case Rep Dermatol 2018 May-Aug;10(2):138-144. Epub 2018 May 24.

King Saud bin Abdul-Aziz University for Health Sciences, Riyadh, Saudi Arabia.

Background: Nevus lipomatosis cutaneous superficialis (NLCS) is a rare hamartoma of mature adipose tissue characterized by solitary or multiple, soft, skin-colored or yellowish lobules that may coalesce to give rise to plaques with a cerebriform surface. There are two clinical types: (1) multiple lesions that are usually presented in a segmental distribution and (2) a solitary papule or nodule.

Aim And Objective: To study the clinical and histopathological features of 5 Saudi patients with NLCS. Read More

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http://dx.doi.org/10.1159/000488900DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6006638PMC
May 2018
5 Reads

Basal Cell Carcinoma Mimicking Desmoplastic Trichoepithelioma: A Case with Correlation of Dermoscopy and Histology.

Case Rep Dermatol 2018 May-Aug;10(2):133-137. Epub 2018 May 18.

Dermatology Clinic, University Hospital Zurich, Zurich, Switzerland.

Basal cell carcinoma (BCC) is the most common cancer in humans worldwide. Many highly specific dermoscopic criteria for BCC are well established in the literature. On the contrary, other malignant or benign skin tumors may mimic BCC by exhibiting similar or even the same dermoscopic features and therefore obscuring the diagnosis of BCC in certain situations. Read More

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http://dx.doi.org/10.1159/000489164DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6006647PMC
May 2018
4 Reads

Efficacy and Tolerability of Topical Green Tea Extract (Polyphenon E) Application in a "Therapy-Resistant" Plantar Wart.

Case Rep Dermatol 2018 May-Aug;10(2):127-132. Epub 2018 May 18.

Medical Department, Cantabria Lab, Difa Cooper, Caronno Pertusella, Italy.

Plantar warts account for 30% of all cutaneous warts. These lesions could be very painful, especially if the lesion is located over pressure sites such as the metatarsal head. Plantar wart treatment remains a challenging therapeutic problem. Read More

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http://dx.doi.org/10.1159/000489160DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6006655PMC
May 2018
23 Reads

Chronic Prurigo: An Unusual Presentation of Hodgkin Lymphoma.

Case Rep Dermatol 2018 May-Aug;10(2):122-126. Epub 2018 May 17.

Department of Dermatology, Geneva University Hospital, Geneva, Switzerland.

Background: Prurigo nodularis is a condition of unknown origin defined by papulonodular eruption and intense pruritus. Hodgkin lymphoma often presents nonspecific initial symptoms. An association between systemic malignancy and cutaneous manifestations has long been documented. Read More

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http://dx.doi.org/10.1159/000489161DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6006658PMC
May 2018
15 Reads

Porphyria Cutanea Tarda Presenting with Scleroderma, Ichthyosis, Alopecia, and Vitiligo.

Case Rep Dermatol 2018 May-Aug;10(2):115-121. Epub 2018 May 17.

Division of Dermatology, Department of Medicine, University of Alberta, Edmonton, Alberta, Canada.

Porphyria cutanea tarda (PCT) is a cutaneous porphyria that presents later in life with cutaneous findings in sun-exposed sites. We report a complex case of PCT in a 67-year-old woman with an unusual constellation of cutaneous findings: scleroderma, acquired ichthyosis, and nonscarring alopecia. Possible triggers for her PCT include tamoxifen treatment for breast cancer and carrier status of the hemochromatosis gene. Read More

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http://dx.doi.org/10.1159/000488899DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6006631PMC
May 2018
6 Reads

Anti-MDA5 Antibody-Positive Dermatomyositis Presenting with Cellulitis-Like Erythema on the Mandible as an Initial Symptom.

Case Rep Dermatol 2018 May-Aug;10(2):110-114. Epub 2018 May 4.

Department of Dermatology, Gifu University Graduate School of Medicine, Gifu, Japan.

Panniculitis is an uncommon skin eruption observed in patients with dermatomyositis (DM)/clinically amyopathic dermatomyositis (CADM), especially in anti-melanoma differentiation-associated gene 5 (MDA5) antibody-positive DM. We present here a 51-year-old Japanese woman with an anti-MDA5 antibody-positive DM who initially had cellulitis-like erythema on her right mandible. Histopathological findings showed a subcutaneous lobular infiltration of lymphocytes. Read More

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http://dx.doi.org/10.1159/000488077DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5981633PMC
May 2018
4 Reads

Unilateral Focal Dermal Hypoplasia (Goltz Syndrome): Case Report and Literature Review.

Case Rep Dermatol 2018 May-Aug;10(2):101-109. Epub 2018 May 3.

Dental Department, King Abdulaziz University, Jeddah, Saudi Arabia.

Focal dermal hypoplasia (FDH) or Goltz syndrome is a rare X-linked dominant multisystemic disease involving the ectoderm, mesoderm, and endoderm. About 95% of the cases appear de novo, and 90% of them are females. Recently, the studies revealed that FDH is caused by a mutation in the PORCN gene. Read More

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http://dx.doi.org/10.1159/000488521DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5981586PMC
May 2018
3 Reads

Successful Treatment of Pityriasis Rubra Pilaris with Ixekizumab.

Case Rep Dermatol 2018 May-Aug;10(2):97-100. Epub 2018 May 2.

Department of Dermatology, Kepler University Hospital Linz, Linz, Austria.

Pityriasis rubra pilaris is an inflammatory dermatologic disorder of unknown cause and often confounded with psoriasis. It is characterised by hyperkeratotic follicular papules, scaly erythematous plaques, palmoplantar keratoderma, and a progression to generalised erythroderma. Here, we report the case of a 68-year-old man with pityriasis rubra pilaris, who was successfully treated with ixekizumab, an interleukin-17A inhibitor. Read More

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http://dx.doi.org/10.1159/000488902DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5981592PMC
May 2018
7 Reads

Juvenile Localized Scleroderma with Hyaline Deposits in the Renal Arteriole.

Case Rep Dermatol 2018 Jan-Apr;10(1):89-95. Epub 2018 Apr 24.

Department of Pediatrics, Japanese Red Cross Sendai Hospital, Taihaku-ku, Sendai, Japan.

We report a 10-year-old boy with localized scleroderma of the linear and plaque type, who showed proteinuria and hematuria. In this patient, skin, articular, and renal manifestations appeared successively and then began to resolve in the same order. A renal biopsy specimen demonstrated mild mesangial cell proliferation, exudate of immunoglobulin in the glomerular capillary, and large electron-dense deposits in the afferent arteriole. Read More

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http://dx.doi.org/10.1159/000488901DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5968237PMC
April 2018
4 Reads

Hereditary Leukonychia Totalis: A Case Report and Review of the Literature.

Case Rep Dermatol 2018 Jan-Apr;10(1):82-88. Epub 2018 Apr 12.

Ramathibodi Medical Center, Mahidol University, Bangkok, Thailand.

Leukonychia is defined as white discoloration of the nails caused by an abnormal keratinization of the nail matrix. Congenital leukonychia totalis is a rare nail disorder, which is typically inherited in an autosomal dominant pattern. This condition can be presented as an isolated condition or in association with systemic diseases. Read More

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https://www.karger.com/Article/FullText/488522
Publisher Site
http://dx.doi.org/10.1159/000488522DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5968238PMC
April 2018
11 Reads

Adenolipoma of the Skin: A Report of 11 Cases.

Case Rep Dermatol 2018 Jan-Apr;10(1):76-81. Epub 2018 Apr 5.

Pathology Services Division, Johns Hopkins Aramco Healthcare, Dhahran, Saudi Arabia.

Introduction: Adenolipoma is a relatively recently described lesion representing a rare variant of lipoma in which eccrine glands and ducts are found interspersed amongst mature adipose tissue. This benign lesion was first described by Hitchcock et al. in 1993 [J Am Acad Dermatol 1993; 29: 82-85]. Read More

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http://dx.doi.org/10.1159/000488341DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5968233PMC
April 2018
3 Reads

A Case of Ceftriaxone-Induced Acute Generalized Exanthematous Pustulosis/Generalized Pustular Psoriasis Overlap.

Case Rep Dermatol 2018 Jan-Apr;10(1):69-75. Epub 2018 Mar 27.

Department of Dermatology, Shanghai Skin Disease Hospital, Shanghai, China.

Acute generalized exanthematous pustulosis, characterized by subcorneal or superficial intraepidermal pustules, is induced by drugs in more than 90% of cases. Psoriasis is an autoimmune disease triggered by different conditions in genetically susceptible people. Generalized pustular psoriasis is an acute and severe clinical form of psoriasis, which usually occurs in patients with psoriasis undergoing aggravating factors. Read More

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http://dx.doi.org/10.1159/000488076DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5903148PMC
March 2018
5 Reads

Incidental Squamous Cell Carcinoma in an Epidermal Inclusion Cyst: A Case Report and Review of the Literature.

Case Rep Dermatol 2018 Jan-Apr;10(1):61-68. Epub 2018 Mar 22.

Department of Otolaryngology - Head and Neck Surgery, Loma Linda University, Loma Linda, California, USA.

Epidermal inclusion cysts are common lesions that rarely develop into squamous cell carcinoma (SCC). Neoplastic change in these cysts can be associated with prominent symptoms such as pain, rapid growth, or ulceration. This study describes the case of a 64-year-old woman with a 4-year history of a largely asymptomatic neck mass, which after routine excision was found to be an epidermal inclusion cyst harboring well-differentiated SCC. Read More

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http://dx.doi.org/10.1159/000487794DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5903124PMC
March 2018
7 Reads

The Importance of Excluding Cutaneous T-Cell Lymphomas in Patients with a Working Diagnosis of Papuloerythroderma of Ofuji: A Case Series.

Case Rep Dermatol 2018 Jan-Apr;10(1):46-54. Epub 2018 Feb 21.

Division of Dermatology, University of Ottawa, Ottawa, Ontario, Canada.

Papuloerythroderma of Ofuji (PEO) is an erythroderma-like eruption with flat-topped papules that spare the skin folds (a "deck-chair sign" finding). Many infections, medications, and systemic diseases have been associated with PEO, including cutaneous T-cell lymphomas (CTCL). The relationship between the clinical presentation of PEO and CTCL remains poorly elucidated. Read More

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http://dx.doi.org/10.1159/000487473DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5869582PMC
February 2018
9 Reads

A Case of Vulvar Schwannoma Mimicking Epidermoid Cyst.

Case Rep Dermatol 2018 Jan-Apr;10(1):41-45. Epub 2018 Feb 15.

Department of Medical Mycology, Shanghai Dermatology Hospital, Shanghai, China.

Schwannoma is a generally benign tumor of the peripheral nerve sheath arising from Schwann cells. Most schwannomas are found on the head and neck. Here, we describe a rare case of benign vulvar schwannoma located at the labium majus which was similar to an epidermoid cyst in clinical appearance. Read More

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http://dx.doi.org/10.1159/000487125DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5869558PMC
February 2018
7 Reads

Extensive Lepromatous Lymphadenitis Preceding Lesions on the Face and Earlobes: An Unusual Presentation of Leprosy in Singapore.

Case Rep Dermatol 2018 Jan-Apr;10(1):35-40. Epub 2018 Feb 14.

Division of General Medicine, National University Health Systems, Singapore, Singapore.

Leprosy is also known as Hansen disease, as in some countries the diagnosis of leprosy carries a negative stigma and patients fear being shunned as outcasts. Presently, leprosy is primarily limited to specific geographical regions in resource-poor countries. As a result, there is increased difficulty for the younger generation of physicians today to correctly identify leprosy due to a lack of exposure and a low-index of suspicion, particularly in developed countries. Read More

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http://dx.doi.org/10.1159/000462959DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5869576PMC
February 2018
31 Reads

Successful Treatment of Inflammatory Linear Verrucous Epidermal Nevus with Concomitant Psoriasis Using Etanercept.

Case Rep Dermatol 2018 Jan-Apr;10(1):29-34. Epub 2018 Feb 14.

Consultant Internist, Hera General Hospital, Makkah, Saudi Arabia.

Linear psoriasis is a rare form of the disease characterized by the linear distribution of lesions involving dermatome or along Blaschko's lines. Clinically, it may resemble inflammatory linear verrucous epidermal nevus; a combination of history, skin examination, and histopathology are required to ensure correct diagnosis and appropriate therapy. This paper describes a case of a 23-year-old male presenting with unilateral erythematous scaly plaques arranged in a linear path on the left leg. Read More

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http://dx.doi.org/10.1159/000487001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5869485PMC
February 2018
5 Reads

Incidental Treatment of a Subclinical Chronic Tension-Type Headache by Cosmetic Use of Botulinum Toxin A: A Case Report.

Case Rep Dermatol 2017 Sep-Dec;9(3):249-253. Epub 2017 Nov 27.

Department of Plastic and Breast Surgery, Zealand University Hospital, Roskilde, Denmark.

Background: Headache is a common disorder of the nervous system; chronic headache in particular may affect quality of life negatively. The pathophysiology is multifactorial and not completely elucidated. Studies have demonstrated the beneficial effects of botulinum toxin A on chronic migraine headaches, but failed to show the same effect on chronic tension-type headaches. Read More

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http://dx.doi.org/10.1159/000484657DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5836173PMC
November 2017
4 Reads

Large-Cell Transformed Mycosis Fungoides Coexisting with Mycosis Fungoides Bullosa: A Case Report and Review of the Literature.

Case Rep Dermatol 2017 Sep-Dec;9(3):243-248. Epub 2017 Nov 27.

Division of Dermatology, Department of Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.

Mycosis fungoides is the most common form of cutaneous T-cell lymphoma. Both large-cell transformed mycosis fungoides and mycosis fungoides bullosa are rare presentations and predict unfavorable prognosis. We report the case of a 61-year-old woman who presented with generalized erythematous scaly annular plaques, and histopathology confirmed the diagnosis of mycosis fungoides. Read More

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https://www.karger.com/Article/FullText/484472
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http://dx.doi.org/10.1159/000484472DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5836154PMC
November 2017
20 Reads

Giant Congenital Melanocytic Nevi: An Update and Emerging Therapies.

Case Rep Dermatol 2018 Jan-Apr;10(1):24-28. Epub 2018 Feb 8.

cDepartment of Pediatrics, Richmond University Medical Center, New York, NY, USA.

Giant congenital melanocytic nevi (GCMN) are a rare occurrence. Gain-of-function mutation in the NRAS gene is found to be associated with GCMN, causing abnormal proliferation of embryonic melanoblasts. The two major complications associated with GCMN are malignant melanoma and neurocutaneous melanosis. Read More

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http://dx.doi.org/10.1159/000487002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5836163PMC
February 2018
15 Reads

Non-Melanoma Skin Cancers at Sites of Previous Frostbite: Case Report and Review.

Case Rep Dermatol 2018 Jan-Apr;10(1):17-23. Epub 2018 Feb 1.

bDepartment of Biomedical Sciences, Nazarbayev University School of Medicine, Astana, Kazakhstan.

The association between ultraviolet radiation exposure and skin cancer is well established. Limited studies have reported an association between frostbite and the development of non-melanoma skin cancer but evidence for a proven link is insufficient and possible carcinogenic mechanisms have not been fully explored. In this report, 3 cases of non-melanoma skin cancer (1 case of basal cell carcinoma and 2 cases of squamous cell carcinoma of the skin) which developed at a site of previous frostbite caused by exposure to extremely cold temperatures in Astana, the capital city of Kazakhstan, are described. Read More

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http://dx.doi.org/10.1159/000486477DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5836220PMC
February 2018
9 Reads

Sarcomatoid Tumor following Radium Treatment.

Case Rep Dermatol 2018 Jan-Apr;10(1):13-16. Epub 2018 Jan 31.

aDepartment of Plastic and Breast Surgery, Zealand University Hospital, Roskilde, Denmark.

Haemangiomas are benign skin lesions that usually regress spontaneously, but radiotherapy has previously been used to assist the regression and healing of the lesions. Radium and X-rays were used as a treatment for benign skin lesions such as haemangioma until the carcinogenic effect of ionising radiation in humans was described. We report a patient diagnosed with a sarcomatoid carcinoma. Read More

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http://dx.doi.org/10.1159/000486476DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5836226PMC
January 2018
20 Reads

Acute Erythroderma in a Patient Receiving TNF-α-Blocking Therapy for Hidradenitis Suppurativa.

Case Rep Dermatol 2018 Jan-Apr;10(1):7-12. Epub 2018 Jan 31.

Dermatology, Erasme Hospital, Université Libre de Bruxelles, Brussels, Belgium.

Tumor necrosis factor-α (TNF-α) normally binds to TNF-α receptors, leading to the inflammatory response of autoimmune diseases. Adalimumab is a TNF-inhibiting, anti-inflammatory, biological medication which binds to TNF-α, thus reducing this inflammatory response. The use of TNF-α-inhibiting medication, such as adalimumab, being the first FDA-approved treatment for hidradenitis suppurativa, has drastically changed the management of dermatological diseases. Read More

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https://www.karger.com/Article/FullText/485911
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http://dx.doi.org/10.1159/000485911DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5836174PMC
January 2018
7 Reads

A Case of Erythema Multiforme Major Developed after Sequential Use of Two Immune Checkpoint Inhibitors, Nivolumab and Ipilimumab, for Advanced Melanoma: Possible Implication of Synergistic and/or Complementary Immunomodulatory Effects.

Case Rep Dermatol 2018 Jan-Apr;10(1):1-6. Epub 2018 Jan 18.

Department of Dermatology, Division of Medical Sciences, University of Fukui, Fukui, Japan.

Immune checkpoint inhibitors, such as ipilimumab and nivolumab, reverse the imbalance of antitumor self-tolerance and enhance T-cell responses. Currently, ipilimumab and nivolumab have a reported therapeutic impact on unresectable or metastatic melanomas; however, they also induce immune-related adverse events (irAEs). Ipilimumab-induced cutaneous irAEs are mostly low grade and manageable, although all-grade rash may occur in approximately 45% of all patients. Read More

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http://dx.doi.org/10.1159/000485910DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5836162PMC
January 2018
8 Reads

Acrodermatitis Continua of Hallopeau with Bone Resorption in an 8-Year-Old Patient: A Case Report.

Case Rep Dermatol 2017 Sep-Dec;9(3):259-264. Epub 2017 Dec 18.

Department of Dermatology, King Saud University Medical City, Riyadh, Saudi Arabia.

Acrodermatitis continua of Hallopeau (ACH) is an uncommon inflammatory disease manifesting as sterile pustular eruption of the fingers and toes. The disease is of a chronic relapsing nature and is often refractory to treatment. With longstanding disease, osteitis with consequent bone resorption of the underlying phalanges can occur, leading to disability. Read More

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http://dx.doi.org/10.1159/000485370DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5803711PMC
December 2017
8 Reads

Cutaneous Metastases from Salivary Duct Carcinoma of the Submandibular Gland.

Case Rep Dermatol 2017 Sep-Dec;9(3):254-258. Epub 2017 Dec 5.

Department of Plastic and Breast Surgery, Zealand University Hospital - Roskilde, Roskilde, Denmark.

Salivary duct carcinoma is a rare and highly aggressive malignant neoplasm that frequently metastasises to other organs, but cutaneous metastasis is uncommon. There are only 6 cases reported in the literature with metastases to the skin and in all cases the tumour originates from the parotid gland. We present a case of skin metastases from the submandibular gland that was mistaken for basal cell carcinoma. Read More

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http://dx.doi.org/10.1159/000485371DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5803712PMC
December 2017
37 Reads

Fenofibrate-Induced Lichenoid Drug Eruption: A Rare Culprit.

Case Rep Dermatol 2017 Sep-Dec;9(3):236-242. Epub 2017 Nov 14.

Department of Rheumatology, Presence Saint Joseph Hospital, Chicago, Illinois, USA.

A lichenoid drug eruption is a rare side effect which can occur following the administration of several different medications. Here we describe a unique case of fenofibrate as the causative agent of a lichenoid drug eruption. This case highlights a rare and clinically significant dermatologic side effect of fenofibrate. Read More

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https://www.karger.com/Article/FullText/484471
Publisher Site
http://dx.doi.org/10.1159/000484471DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5731139PMC
November 2017
20 Reads