617 results match your criteria Case reports in dermatology[Journal]


Nivolumab for Metastatic Cutaneous Squamous Cell Carcinoma.

Case Rep Dermatol 2020 Jan-Apr;12(1):37-41. Epub 2020 Feb 12.

Department of Dermatology, University Hospital of Pontevedra, Pontevedra, Spain.

Nivolumab is a programmed death receptor 1 (PD-1) inhibitor. It is part of a group of drugs known as immune checkpoint blockers, which enable potent and durable T-cell responses against several tumors. We report the case of a patient with a metastatic squamous cell carcinoma, who is being treated with nivolumab. Read More

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http://dx.doi.org/10.1159/000505478DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7315375PMC
February 2020

A Case of Pincer Nail Successfully Treated with Tazarotene 0.1% Gel.

Case Rep Dermatol 2020 May-Aug;12(2):114-118. Epub 2020 May 18.

Dermatology Unit, Department of "Medicina dei Sistemi," University of Rome Tor Vergata, Rome, Italy.

Pincer nail is a common condition characterized by excessive transverse nail curvature, progressively pinching the nail bed distally, resulting in cosmetic discomfort, pain and functional limitation. Treatment is difficult and often unsatisfactory. Surgical treatment performed by experienced physicians provides good outcomes. Read More

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http://dx.doi.org/10.1159/000507915DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7265718PMC

Extramammary Paget's Disease and Melanoma: 2 Cases of Double Cancers.

Case Rep Dermatol 2020 May-Aug;12(2):107-113. Epub 2020 May 18.

Department of Plastic Surgery, Herlev-Gentofte Hospital, Copenhagen University Hospital, Herlev, Denmark.

Extramammary Paget's disease (EMPD) is a rare intraepidermal neoplastic disease. There is a well-known relationship between EMPD and underlying malignancy. However, only a few cases of EMPD and cutaneous melanoma have been reported previously. Read More

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http://dx.doi.org/10.1159/000507917DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7265716PMC

Reflectance Confocal Microscopy of Pigmented Bowen's Disease: A Case Series of Difficult to Diagnose Lesions.

Case Rep Dermatol 2020 May-Aug;12(2):98-106. Epub 2020 May 15.

Department of Medicine and Medical Specialties, University of Alcalá, Madrid, Spain.

Pigmented Bowen's disease is a rare variant of in situ squamous skin cell carcinoma. It mainly affects patients between 60 and 70 years of age. Its clinical features include well-demarcated, pigmented plaque arising in photo-exposed areas of the body. Read More

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http://dx.doi.org/10.1159/000507916DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7265740PMC

A Case of Dermatomyositis Coexisting with Both Anti-Mi-2 and Anti-NXP-2 Antibodies.

Case Rep Dermatol 2020 May-Aug;12(2):92-97. Epub 2020 May 5.

Department of Dermatology, Gifu University Graduate School of Medicine, Gifu, Japan.

Myositis-specific autoantibodies (MSAs) including anti-Mi-2 and anti-nuclear matrix protein 2 (NXP-2) antibodies have been detected in the patients with dermatomyositis (DM), and are useful tools for identifying clinical subsets of DM. MSAs are exclusively found in DM patients. Anti-Mi-2 antibody-positive DM patients show the typical skin lesions and myositis and are rarely associated with internal malignancy and interstitial lung disease (ILD). Read More

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http://dx.doi.org/10.1159/000507504DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7250387PMC

Atypical Clinical Presentation of Hidradenitis Suppurativa in a Patient with Severe Mannose-Binding Lectin Deficiency.

Case Rep Dermatol 2020 May-Aug;12(2):83-91. Epub 2020 May 5.

Department of Dermatology, Alpert Medical School, Brown University, Providence, Rhode Island, USA.

Mannose-binding lectin (MBL) deficiency is associated with recurrent infections, autoimmune and inflammatory skin disease, and vascular complications. MBL deficiency is not a recognized comorbidity in hidradenitis suppurativa (HS); the latter is associated with the group of autoinflammatory disorders. A 32-year-old woman presented with a history of recurrent painful, deep-seated abscesses and pustular lesions since the age of 13 years. Read More

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http://dx.doi.org/10.1159/000507539DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7250386PMC

Exfoliative Erythroderma: An Unusual Presentation of Paraneoplastic Pemphigus Associated with Castleman's Disease.

Case Rep Dermatol 2020 Jan-Apr;12(1):76-81. Epub 2020 Apr 14.

Division of Dermatology, Department of Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.

We report a 23-year-old woman who presented with generalized scaly erythematous rash predominately on the upper trunk and hemorrhagic stomatitis. The histopathologic and immunopathologic findings were consistent with the diagnosis of paraneoplastic pemphigus. Castleman's tumor was diagnosed with computed tomography and exploratory laparotomy. Read More

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http://dx.doi.org/10.1159/000507357DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7184796PMC

Unusual Presentation of Cutaneous Spindle Cell Squamous Cell Carcinoma: A Case Report.

Case Rep Dermatol 2020 Jan-Apr;12(1):70-75. Epub 2020 Apr 8.

Department of Pathology, Zealand University Hospital, Roskilde, Denmark.

Cutaneous spindle cell squamous cell carcinoma (SpSCC) is a rare and often aggressive subtype of squamous cell carcinoma (SCC), which usually appears in sun-exposed areas, in areas that have received prior ionizing radiation, or in immunosuppressed individuals. SpSCCs are histologically characterized by keratinocytes infiltrating the dermis as single cells with elongated nuclei rather than as cohesive nests or islands and, in contrast to conventional SCC, are lacking features of keratinization. Immunohistochemical studies are useful to distinguish SpSCC from other spindle cell neoplasms, such as spindle cell/desmoplastic melanoma, cutaneous leiomyosarcoma, and atypical fibroxanthoma. Read More

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http://dx.doi.org/10.1159/000507358DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7184790PMC

Netherton's Syndrome: A Case of Two Male Siblings Diagnosed in Adulthood.

Case Rep Dermatol 2020 Jan-Apr;12(1):64-69. Epub 2020 Apr 8.

Department of Dermatology, Westmead Hospital, Sydney, New South Wales, Australia.

Netherton's syndrome (NS) is a rare autosomal recessive genetic disease caused by a germline mutation in the SPINK5 gene. It is most commonly diagnosed in neonates due to the presence of congenital ichthyosiform erythroderma. Affected individuals will typically also develop a hair shaft abnormality known as trichorrhexis invaginata, severe atopy, and a migratory rash known as ichythyosis linearis circumflexa. Read More

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http://dx.doi.org/10.1159/000507359DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7184789PMC

Acral Cutaneous Ulcerations and Livedo Reticularis with Rapidly Progressive Interstitial Lung Disease in Anti-MDA5 Antibody-Positive Classical Dermatomyositis.

Case Rep Dermatol 2020 Jan-Apr;12(1):57-63. Epub 2020 Mar 20.

Division of Rheumatology, Department of Medicine, Faculty of Medicine, Srinagarind Hospital, Khon Kaen University, Khon Kaen, Thailand.

Rapidly progressive interstitial lung disease (RP-ILD) and its distinctive cutaneous features are highly associated with the presence of anti-melanoma differentiation-associated gene 5 (anti-MDA5) antibody in patients with dermatomyositis (DM), leading to a poor prognosis. We describe the case of a 25-year-old man who developed progressive proximal muscle weakness with RP-ILD and had unusual cutaneous findings (cutaneous ulcerations and livedo reticularis) accompanied by classical cutaneous features (heliotrope rash, Gottron's papules, Gottron's sign, and flagellate erythema). Blood test was positive for anti-MDA5 antibody. Read More

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http://dx.doi.org/10.1159/000506668DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7154252PMC

Palisaded Neutrophilic and Granulomatous Dermatitis in a Patient with Granulomatosis with Polyangiitis.

Case Rep Dermatol 2020 Jan-Apr;12(1):52-56. Epub 2020 Mar 20.

Department of Dermatology, Gifu University Graduate School of Medicine, Gifu, Japan.

Palisaded neutrophilic and granulomatous dermatitis (PNGD) shows various clinical features and is histologically characterized by palisaded granulomas surrounding degenerated collagen. PNGD is known to be associated with a variety of systemic conditions such as rheumatoid arthritis and systemic lupus erythematosus. Furthermore, PNGD has been reported to be associated with antineutrophilic cytoplasmic antibody-associated vasculitis, including granulomatosis with polyangiitis (GPA) and microscopic polyangiitis. Read More

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http://dx.doi.org/10.1159/000506670DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7154257PMC

Lichenoid Keratosis: A Clinical Trap without Secrets for Reflectance Confocal Microscopy.

Case Rep Dermatol 2020 Jan-Apr;12(1):47-51. Epub 2020 Mar 20.

Dermatologic Unit, University of Rome Tor Vergata, Rome, Italy.

Lichenoid keratosis, also defined as benign lichenoid keratosis, was reclassified as lichen planus-like keratosis by Shapiro and Ackerman. Clinical and dermoscopic features of lichen planus-like keratosis can vary, often not providing useful and necessary information to perform an accurate diagnosis without performing a biopsy or histological examination. We describe 2 difficult to detect lichen planus-like keratosis cases in which we performed reflectance confocal microscopy. Read More

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http://dx.doi.org/10.1159/000506669DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7154274PMC

Development of Bullous Pemphigoid after Tenckhoff Catheter Placement in a Peritoneal Dialysis Patient.

Authors:
Davide Giunzioni

Case Rep Dermatol 2020 Jan-Apr;12(1):42-46. Epub 2020 Mar 17.

Division of Nephrology, Department of Internal Medicine, Ospedale Regionale di Lugano, Ente Ospedaliero Cantonale, Lugano, Switzerland.

Bullous pemphigoid (BP), a chronic autoimmune subepidermal blistering skin disease, has been described in end-stage renal disease patients requiring dialysis after the placement of an artero-venous fistula. We report a case of a novel onset of BP following a peritoneal dialysis abdominal Tenckhoff catheter placement. The 3-month treatment with systemic doxycycline and topical clobetasol propionate allowed a rapid disappearing of the blisters and left the patient free of symptoms in the follow-up. Read More

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http://dx.doi.org/10.1159/000506667DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7154232PMC

Bullous Pemphigoid in Which Eruption Developed Exclusively on Preexisting Eruption of Vitiligo Vulgaris.

Case Rep Dermatol 2020 Jan-Apr;12(1):33-36. Epub 2020 Feb 4.

Division of Dermatology, Department of Internal Related, Kobe University Graduate School of Medicine, Kobe, Japan.

Coexistence of bullous pemphigoid (BP) and vitiligo vulgaris (VV) is very rare. We present a unique case of BP associated with VV in a 76-year-old Japanese man, in which BP eruption developed exclusively on preexisting VV regions. The patient was referred to us with a 3-month history of blistering eruption with severe pruritis on the right forearm and left lower limb. Read More

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http://dx.doi.org/10.1159/000505829DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7036583PMC
February 2020

Multiple Fixed Drug Eruption Mimicking Parapsoriasis en Plaque in a Patient with Hepatitis C Virus Infection.

Case Rep Dermatol 2020 Jan-Apr;12(1):25-32. Epub 2020 Feb 4.

Department of Dermatology, Kyorin University School of Medicine, Tokyo, Japan.

Although hepatitis C virus (HCV) infection is often associated with extrahepatic cutaneous manifestations such as lichen planus, it is unclear whether HCV or HCV-specific immune responses play a pathophysiological role in the development of HCV-related cutaneous diseases. We recently treated a patient who developed parapsoriasis en plaque-like lesions after ingestion of various drugs. She showed hypersensitivity to multiple drugs after interferon therapy. Read More

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http://dx.doi.org/10.1159/000505477DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7036541PMC
February 2020

Transformation of Seborrheic Keratosis into Bowenoid Actinic Keratosis via Three Steps of Histological Change in a Patient with Rheumatoid Arthritis Treated with Multiple Immunosuppressants.

Case Rep Dermatol 2020 Jan-Apr;12(1):19-24. Epub 2020 Feb 4.

Department of Plastic and Reconstructive Surgery, Kita-Harima Medical Center, Ono City, Japan.

We report a case of seborrheic keratosis (SK) that transformed into bowenoid actinic keratosis (AK) via three steps of histological change in a 77-year-old woman. The patient presented with a multiple-year history of a brownish lesion on the right cheek. She reported that some months earlier she had noted a pinkish lesion developing within the brownish lesion. Read More

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http://dx.doi.org/10.1159/000505530DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7036593PMC
February 2020

Primary Idiopathic Complex Aphthosis: Diagnosis and Successful Treatment with Montelukast in a 44-Year-Old Filipino Female.

Case Rep Dermatol 2020 Jan-Apr;12(1):12-18. Epub 2020 Feb 4.

Skin and Cancer Foundation, Inc., Pasig City, Philippines.

Recurrent aphthous stomatitis (RAS) is an oral condition characterized by frequent attacks of painful oral ulcers. Complex aphthosis (CA) is a severe form of RAS described as the almost constant presence of ≥3 oral ulcers with or without genital aphthosis. Management of primary CA varies, but most patients warrant the use of systemic agents. Read More

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http://dx.doi.org/10.1159/000505475DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7036591PMC
February 2020

Uncommon Location of Purpura Fulminans: Case Report and Literature Review.

Case Rep Dermatol 2020 Jan-Apr;12(1):5-11. Epub 2020 Jan 15.

King Abdul Aziz University, Jeddah, Saudi Arabia.

Purpura fulminans is a critical, mostly fatal, thrombotic syndrome that requires urgent intervention. Purpura fulminans is an acute purpuric rash characterized by coagulation of the microvasculature, which leads to purpuric lesions and skin necrosis. In this report, we present a rare case of an adult patient who was admitted with rapidly forming purpura fulminans in an uncommon location. Read More

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http://dx.doi.org/10.1159/000505476DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7011717PMC
January 2020

Cell Thumb Replaces Writer's Bump: Changing Times, Changing Callouses.

Case Rep Dermatol 2020 Jan-Apr;12(1):1-4. Epub 2020 Jan 6.

Bay Area Cosmetic Dermatology, San Francisco, California, USA.

Common callouses are formed by the accumulation of keratinocytes in the stratum corneum in response to excess pressure or friction. We report 2 cases of unusual callous formation and an additional 25 more sequential cases that were due to excessive cell phone grip. Read More

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http://dx.doi.org/10.1159/000505310DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6984141PMC
January 2020

A Case of Salazosulfapyridine-Induced Hypersensitivity Syndrome in a Rheumatoid Arthritis Patient with Relapse of Skin Erythema.

Case Rep Dermatol 2019 Sep-Dec;11(3):334-337. Epub 2019 Dec 17.

Department of Dermatology, Osaka University Graduate School of Medicine, Suita, Japan.

We experienced a rare case of drug-induced hypersensitivity syndrome (DIHS) in which salazosulfapyridine (SASP) reactivated human herpesvirus 6 (HHV-6) and cytomegalovirus (CMV), which resulted in a relapse of skin symptoms after changing to mizoribine. At the time of recurrence of skin erythema after the initiation of mizoribine, the serum DNA titers of not HHV-6 but CMV were elevated. A drug-induced lymphocyte stimulation test was negative for mizoribine but positive for SASP. Read More

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http://dx.doi.org/10.1159/000504644DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6959106PMC
December 2019

Darier's Disease: Report of a Case with Facial Involvement.

Case Rep Dermatol 2019 Sep-Dec;11(3):327-333. Epub 2019 Dec 10.

Division of Dermatology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.

Darier's disease is a relatively rare autosomal dominant genodermatosis with a defect in the desmosomal attachment due to a mutation in the gene. The condition is characterized by multiple hyperkeratotic papules predominantly in seborrheic areas on the head, neck, and trunk, with less frequent involvement of the oral mucosa. Histopathologically, the lesions reveal suprabasal clefts in the epithelium with acantholytic and dyskeratotic cells. Read More

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http://dx.doi.org/10.1159/000504925DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6940465PMC
December 2019

Squamous Cell Carcinoma Associated with Cosmetic Use of Bleaching Agents: About a Case in Ivory Coast.

Case Rep Dermatol 2019 Sep-Dec;11(3):322-326. Epub 2019 Dec 4.

Department of Dermatology and Venereology, University Hospital of Treichville, University Félix Houphouët-Boigny of Abidjan, Abidjan, Ivory Coast.

Voluntary skin depigmentation is defined as a set of procedures for obtaining skin clarification for cosmetic purposes. Skin cancers are possible complications, but rarely reported. We describe a case observed in Ivory Coast. Read More

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http://dx.doi.org/10.1159/000504596DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6940466PMC
December 2019

Psoriasiform Dermatitis Developing during Treatment of Juvenile Idiopathic Arthritis with Tocilizumab.

Case Rep Dermatol 2019 Sep-Dec;11(3):317-321. Epub 2019 Nov 27.

Department of Dermatology, Mie University Graduate School of Medicine, Tsu, Japan.

We present a case of psoriasiform dermatitis developing during the treatment of juvenile idiopathic arthritis with tocilizumab (TCZ). The keratotic erythema with central healing showed a periodicity of growing worse 1 week after TCZ infusion, and then disappeared within 3 weeks. Skin biopsy showed parakeratosis, microabscess, rete ridge elongation, and abundant lymphocytes as well as a few neutrophil infiltrate in the upper dermis. Read More

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http://dx.doi.org/10.1159/000504429DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6940454PMC
November 2019

Efficacy and Tolerability of Topical Polyphenon E in Multiple "Seborrheic Keratosis-Like" Lesions of the Groin in an Immunocompetent 26-Year-Old Man.

Case Rep Dermatol 2019 Sep-Dec;11(3):310-316. Epub 2019 Nov 7.

Medical Department Cantabria Labs Difa Cooper, Caronno Pertusella, Italy.

Polyphenon E 10%, a green tea extract containing epigallocatechin gallate (EGCG) as the main active compound, is a topical formulation indicated for the treatment of genital warts. Polyphenon E has also shown to be very effective in the treatment of periungual and plane warts. Here, we report a dramatic clinical effect of topical treatment with polyphenon E in a subject with multiple "seborrheic keratosis-like" lesions of the genital area. Read More

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http://dx.doi.org/10.1159/000503989DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6902246PMC
November 2019

Methimazole-Induced Leukocytoclastic Vasculitis: A Case Report.

Case Rep Dermatol 2019 Sep-Dec;11(3):303-309. Epub 2019 Nov 1.

Division of Dermatology, Department of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.

Major identifiable causes of leukocytoclastic vasculitis include certain infections and medications. Amongst antithyroid drugs, methimazole (MMI) is rarely implicated as a culprit drug. We report the first case, in Thailand, of MMI-induced leukocytoclastic vasculitis in a 41-year-old Thai female who had received MMI for relapsed Graves' disease. Read More

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http://dx.doi.org/10.1159/000503990DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6873099PMC
November 2019

Fibrosing Alopecia in a Pattern Distribution: A Case Report and Literature Review.

Case Rep Dermatol 2019 Sep-Dec;11(3):297-302. Epub 2019 Oct 16.

Division of Dermatology, Department of Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.

Fibrosing alopecia in a pattern distribution (FAPD) is a relatively new entity in the family of cicatricial alopecia. It has been categorized as a member of the lichen planopilaris (LPP) group due to its similarity in clinical and histopathological presentation. Nonetheless, the disease earns its own entity due to its lichenoid inflammation exclusively involving miniaturized hair and area of involvement mimicking pattern hair loss which differentiates itself from other types of LPP or pattern hair loss. Read More

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http://dx.doi.org/10.1159/000503681DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6873076PMC
October 2019

Punctate Palmoplantar Keratoderma: A Case Report of Type 1 (Buschke-Fischer-Brauer Disease).

Case Rep Dermatol 2019 Sep-Dec;11(3):292-296. Epub 2019 Oct 10.

Faculty of Health, Medicine and Life Sciences, Maastricht university, Maastricht, The Netherlands.

Punctate palmoplantar keratoderma is a rare hereditary palmoplantar keratoderma. Herein we report a 59-year-old male, otherwise healthy, who presented with a 25-year history of asymptomatic persistent slowly progressing skin lesions on both hands. The parents are non-consanguineous and none of his family members had similar lesions. Read More

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http://dx.doi.org/10.1159/000503337DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6873031PMC
October 2019

Multiple Dorsal Hand Actinic Keratoses and Squamous Cell Carcinomas: A Unique Presentation following Extensive UV Nail Lamp Use.

Case Rep Dermatol 2019 Sep-Dec;11(3):286-291. Epub 2019 Oct 2.

Department of Dermatology, University of Toledo Medical Center, Toledo, Ohio, USA.

Squamous cell carcinoma (SCC) is the second most common skin cancer worldwide, and exposure to ultraviolet (UV) light is a major cause of SCC. UV nail lamps can be used for drying and hardening acrylic or gel nail polish. We report a case of a 52-year-old Caucasian woman with an 18-year history of UV nail lamp use every 3 weeks and an 18-year history of weekly tanning bed use who presented with over 25 actinic keratoses and two SCC in situ on her dorsal hands. Read More

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http://dx.doi.org/10.1159/000503273DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6873006PMC
October 2019

A Case Report of Idiopathic Follicular Hyperkeratotic Spicules and Literature Review.

Case Rep Dermatol 2019 Sep-Dec;11(3):278-285. Epub 2019 Oct 2.

Division of Dermatology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.

Follicular hyperkeratotic spicules is a rare skin disorder that is usually associated with multiple myeloma. The condition typically presents with tiny hyperkeratotic spicules in follicular distribution and predominantly on the face. To our knowledge, there has been one reported case of this condition without underlying disease. Read More

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http://dx.doi.org/10.1159/000503272DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6872986PMC
October 2019

Nanoparticle Albumin-Bound Paclitaxel- and/or Gemcitabine-Induced Scleroderma Accompanied by Acanthosis Nigricans-Like Skin Changes.

Case Rep Dermatol 2019 Sep-Dec;11(3):273-277. Epub 2019 Oct 2.

Department of Dermatology, Gunma University Graduate School of Medicine, Maebashi, Japan.

We herein present the first case of nanoparticle albumin-bound paclitaxel (nab-paclitaxel)- and/or gemcitabine-induced scleroderma accompanied by acanthosis nigricans-like skin changes in a 54-year-old Japanese male. He was diagnosed with pancreatic cancer and received 17 courses of nab-paclitaxel and gemcitabine chemotherapy. Edema and skin sclerosis in his legs appeared after the first and third course, respectively. Read More

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http://dx.doi.org/10.1159/000503271DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6873097PMC
October 2019

Erythema Gyratum Repens in Long-Term Smoker.

Case Rep Dermatol 2019 Sep-Dec;11(3):268-272. Epub 2019 Oct 2.

Niagara Dermatology Associates, Lewiston, New York, USA.

Erythema gyratum repens (EGR) is a rare paraneoplastic skin condition characterized by the eruption of expanding, concentric, erythematous patches and plaques. The condition may precede a symptomatic appearance of internal malignancy, and therefore provides a unique opportunity to prevent additional morbidity and mortality secondary to undetectable cancer growth. We report the case of a 71-year-old female patient clinically diagnosed with EGR and subsequently diagnosed with otherwise asymptomatic adenocarcinoma of the lung. Read More

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http://dx.doi.org/10.1159/000503270DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6873075PMC
October 2019

Secukinumab for Psoriasis in Obese Patients: Minireview and Clinical Experience.

Case Rep Dermatol 2019 Sep-Dec;11(Suppl 1):29-36. Epub 2019 Sep 23.

Department of Health Sciences, A. Avogadro University of Eastern Piedmont, Novara, Italy.

Psoriasis (PsO) has been associated with obesity, and its severity increases in obese subjects. The link between psoriatic condition and obesity is based on shared pathophysiological pathways where local and systemic inflammation promote each other; PsO is an inflammatory, immune-mediated disease, and the adipose tissue is the source of proinflammatory adipokines. Moreover, psoriatic arthritis (PsA) is an important comorbidity of PsO that reduces quality of life and makes difficult the patient's management. Read More

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http://dx.doi.org/10.1159/000501990DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6816128PMC
September 2019

Efficacy and Safety of Secukinumab in Patients with Plaque Psoriasis and Latent Tuberculosis.

Case Rep Dermatol 2019 Sep-Dec;11(Suppl 1):23-28. Epub 2019 Sep 23.

Medical Sciences Department, Section of Dermatology, University of Turin, Turin, Italy.

Upon the association of biologic treatments with reactivation of latent tuberculosis infection (LTBI), screening for infection and anti-tuberculosis chemoprophylaxis in positive patients are required prior to biologic drug administration. Nevertheless, the risk of infection relapses associated with biologic drugs seems to be different. No cases of reactivation of LTBI have been observed in secukinumab-treated subjects, in contrast with clinical reports on the risk associated with anti-tumor necrosis factor Α-based therapy. Read More

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http://dx.doi.org/10.1159/000501989DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6816124PMC
September 2019

Optimizing Secukinumab Treatment in Psoriasis with Concomitant Methotrexate Administration: Minireview and A Case Report.

Case Rep Dermatol 2019 Sep-Dec;11(Suppl 1):17-22. Epub 2019 Sep 23.

Department of Dermatology, University of Rome, "La Sapienza", Rome, Italy.

The introduction of biologic drugs for the treatment of moderate-to-severe psoriasis resulted in a significant improvement in patients' health. Moreover, treatment regimens in psoriatic patients should be tailored to meet specific needs based on disease severity, impact on quality of life, response to previous therapies and presence of comorbidities. Combination therapy of biologic agents with conventional systemic drugs has been proposed to optimize psoriasis treatment outcomes in unresponsive or partial responsive severe psoriatic patients. Read More

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http://dx.doi.org/10.1159/000501994DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6816129PMC
September 2019

Secukinumab in the Treatment of Plaque Psoriasis in Patients with Malignancy.

Case Rep Dermatol 2019 Sep-Dec;11(Suppl 1):11-16. Epub 2019 Sep 23.

Dermatology Unit, University of Campania, Naples, Italy.

Although available data are conflicting, psoriasis seems to be associated with an increased baseline risk of malignancy. In addition, some antipsoriatic systemic treatments have been associated with risk of malignancy. There is not enough data on the association of interleukin (IL)-17 and IL-23 inhibitors with malignancy rate, but there have been no cases reported so far. Read More

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http://dx.doi.org/10.1159/000501993DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6816125PMC
September 2019

Treatment of Moderate-to-Severe Psoriasis in the Presence of Kaposi's Varicelliform Eruption.

Case Rep Dermatol 2019 Sep-Dec;11(Suppl 1):4-10. Epub 2019 Sep 23.

Dermatological Unit, Department of Clinical and Molecular Sciences, Polytechnic Marche University, Ancona, Italy.

Kaposi's varicelliform eruption (KVE) is a disseminated cutaneous infection usually induced by herpesvirus type 1 or 2, vaccinia virus or Coxsackie A16 virus in a patient with an underlying dermatosis. Risk factors for KVE reported in the literature include erythroderma, systemic sepsis, therapy with immunosuppressants such as methotrexate and systemic steroids, and therapy with systemic retinoids. The occurrence of KVE in psoriasis is rare and it predominantly appears in patients affected by erythrodermic psoriasis during immunosuppressive treatment. Read More

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http://dx.doi.org/10.1159/000501992DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6816126PMC
September 2019
1 Read

Secukinumab: The Anti-IL-17A Biologic for the Treatment of Psoriasis.

Case Rep Dermatol 2019 Sep-Dec;11(Suppl 1):1-3. Epub 2019 Sep 20.

Department of Dermatology, University of L'Aquila, L'Aquila, Italy.

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http://dx.doi.org/10.1159/000501991DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6816127PMC
September 2019

A Case of Atrophic Dermatofibroma Overexpressing Matrix Metalloproteinase-1.

Case Rep Dermatol 2019 Sep-Dec;11(3):264-267. Epub 2019 Oct 1.

Department of Dermatology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

This case report describes the importance of considering this tumor as one of the differential diagnoses when we encounter a flat and/or atrophic and depressible lesion in the upper portion of the trunk. Read More

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http://dx.doi.org/10.1159/000503136DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6792423PMC
October 2019
1 Read

Acquired Lymphangioma Circumscriptum of the Penis Treated by Electrocoagulation.

Case Rep Dermatol 2019 Sep-Dec;11(3):260-263. Epub 2019 Sep 30.

Service de Dermatologie, CHU de Martinique, Fort de France, France.

Lymphangioma circumscriptum (LC) is a vascular malformation resulting from a developmental anomaly of the superficial lymphatic system of the skin. It is benign albeit uncommon. LC less frequently occurs on the penis. Read More

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http://dx.doi.org/10.1159/000503137DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6792429PMC
September 2019
1 Read

A Rare Case of Atrophic Dermatofibroma Featuring Linear Skin Dimple.

Case Rep Dermatol 2019 Sep-Dec;11(3):256-259. Epub 2019 Sep 30.

Department of Dermatology, Osaka University Graduate School of Medicine, Suita, Japan.

Dermatofibroma (DF) is a benign skin tumor that is well-known among dermatologists. We herein present a rare case of atrophic dermatofibroma presenting linear skin dimpling. The patient was a 25-year-old woman with a history of wild-type recessive dystrophic epidermolysis bullosa who had noticed linear concavity on her right lateral back 1 year before her initial presentation. Read More

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http://dx.doi.org/10.1159/000503413DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6792431PMC
September 2019
2 Reads

Unsuccessful Treatment of Cheilitis Granulomatosa with Oral Methotrexate.

Case Rep Dermatol 2019 Sep-Dec;11(3):249-255. Epub 2019 Sep 27.

Division of Dermatology, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.

Cheilitis granulomatosa (CG) is a rare idiopathic condition with painless lip swelling, characterized by non-necrotizing granulomatous inflammation in the absence of other identifiable causes such as Crohn's disease, sarcoidosis, foreign body reaction, or infection. CG may precede the presentation of Crohn's disease after long-term follow-up. Spontaneous remission of CG rarely occurs. Read More

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http://dx.doi.org/10.1159/000503138DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6792424PMC
September 2019
1 Read

Concurrence of Acrodermatitis Enteropathica and Eczema Herpeticum in a Child with Atopic Dermatitis.

Case Rep Dermatol 2019 Sep-Dec;11(3):240-248. Epub 2019 Sep 10.

Department of Dermatology and Venereology, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada/Dr. Sardjito Hospital, Yogyakarta, Indonesia.

Acrodermatitis enteropathica (AcE) is a rare, autosomal recessive inherited disorder caused by mutation of the gene coding for zinc transport protein (ZIP 4). The disease appears during childhood especially in breastfeeding or post-breastfeeding infant. Eczema herpeticum refers to a disseminated skin infection of herpes simplex virus that usually leads to vesicular eruptions commonly seen on a background of atopic dermatitis (AD). Read More

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http://dx.doi.org/10.1159/000502509DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6787433PMC
September 2019
50 Reads

Perforating Granuloma Annulare Appearing as a Psoriasiform Lesion.

Case Rep Dermatol 2019 May-Aug;11(2):233-238. Epub 2019 Aug 6.

Private Practice Oakview Dermatology, Springfield, Ohio, USA.

We present a 54-year-old Caucasian female with a history of diabetes mellitus, multiple sclerosis, and ulcerative colitis who presented with nail dystrophy, polyarthralgia in her hands and hips, myalgia, proximal myopathy, dactylitis, and psoriasiform-appearing progressive, painful plaques on the dorsal aspect of her hands. Histologic examination of the lesion from the left index finger revealed an interstitial and necrobiotic granulomatous dermatitis with connective tissue mucin deposition associated with a perivascular lymphoid infiltrate. Additionally, there was focal transepidermal elimination of the necrobiotic material. Read More

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http://dx.doi.org/10.1159/000501875DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6738183PMC
August 2019
3 Reads

Bilateral Ear Swelling and Erythema after Chemotherapy: A Case Report of Ara-C Ears.

Case Rep Dermatol 2019 May-Aug;11(2):226-232. Epub 2019 Jul 25.

Division of Dermatology, Department of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.

Cytarabine is an antimetabolite commonly used to treat hematological malignancies, especially acute myeloid leukemia (AML), acute lymphoblastic leukemia, and non-Hodgkin's lymphoma. Cytarabine-induced cutaneous adverse effects are common, usually manifesting as morbilliform eruptions predominantly on the acral site, intertriginous zone, and to a lesser extent on the elbows, knees, neck, and ears. The presentation on ears is usually called "Ara-C ears," which is considered as a rare subtype of acral erythema. Read More

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http://dx.doi.org/10.1159/000501876DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6738253PMC
July 2019
3 Reads

Flagellate Dermatitis by Shiitake Mushroom.

Case Rep Dermatol 2019 May-Aug;11(2):220-225. Epub 2019 Jul 19.

Sector of Dermatology and Post-Graduation Course in Dermatology, University Hospital and School of Medicine, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.

The authors present a case of flagellate dermatitis in a previously healthy young male, triggered by the consumption of shiitake mushrooms. Complete remission without complications was obtained within 7 days, simply by the application of dexamethasone cream 0.1%. Read More

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http://dx.doi.org/10.1159/000498938DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6738184PMC

Linear and Annular Lupus Panniculitis of the Scalp: Case Report with Emphasis on Trichoscopic Findings and Review of the Literature.

Case Rep Dermatol 2019 May-Aug;11(2):157-165. Epub 2019 Jun 6.

Division of Dermatology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.

Linear and annular lupus panniculitis of the scalp (LALPS) is a unique subset of lupus panniculitis, which results in non-scarring alopecia along the Blaschko line of the scalp in an otherwise healthy young patient. Numerous cases have been reported around the world, but data on their trichoscopic findings and correlations with the underlying pathology is sparse. We hereby present a case of 23-year-old male with LALPS and further describe his trichoscopic findings as well as their correlations with histopathological features. Read More

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http://dx.doi.org/10.1159/000500848DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6738250PMC
June 2019
2 Reads

Eccrine Porocarcinoma on the Lateral Nose Wall: A Rare Case Report.

Case Rep Dermatol 2019 May-Aug;11(2):215-219. Epub 2019 Jul 16.

Plastic and Reconstructive Surgery, National Hospital Organization Nagasaki Medical Center, Nagasaki, Japan.

Eccrine porocarcinoma (EPC) is an uncommon malignant tumor derived from the eccrine sweat glands. We present a case of EPC on the lateral nose wall, in which the tumor was excised, and the resultant defect was reconstructed using a nasolabial flap. A 66-year-old female was referred to the Department of Plastic and Reconstructive Surgery to receive treatment for a cutaneous tumor on her right lateral nose wall, which had been growing rapidly for 3 months. Read More

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http://dx.doi.org/10.1159/000501444DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6696782PMC
July 2019
1 Read

Sneddon-Wilkinson Disease and Monoclonal Gammopathy of Undetermined Significance in the Elderly: Case Report.

Case Rep Dermatol 2019 May-Aug;11(2):209-214. Epub 2019 Jul 10.

Dermatology Unit, Department of Clinical and Molecular Sciences, United Hospital of Ancona, Polytechnic Marche University, Ancona, Italy.

Sneddon-Wilkinson disease (SWD) or subcorneal pustular dermatosis is considered a rare pustular skin disease with chronic relapsing course. An association between SWD and other chronic conditions, such as IgA or IgG monoclonal gammopathy of undetermined significance (MGUS), IgA myeloma, pyoderma gangrenosum, thyroid gland disorders, and neoplastic diseases other than MGUS/myeloma, is known. We describe the case of a 92-year-old male patient with SWD and a concurrent IgG MGUS who had been treated with systemic betamethasone, topical mometasone furoate, and methylprednisolone aceponate, with a complete and durable resolution of symptoms and skin lesions without side effects. Read More

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http://dx.doi.org/10.1159/000487003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6696771PMC
July 2019
2 Reads

A Case of Loose Anagen Hair Syndrome in a Southeast Asian Boy.

Case Rep Dermatol 2019 May-Aug;11(2):204-208. Epub 2019 Jul 3.

Division of Dermatology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.

Loose anagen hair syndrome is an uncommon hair disorder, particularly in non-Caucasian children. We report the case of a 13-year-old Thai boy who presented with a single patch of hair thinning on the frontal scalp with excessive shedding, and the hairs did not grow long. Microscopic examination showed naked anagen bulbs with ruffling of the cuticle, which is compatible with loose anagen hair syndrome. Read More

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http://dx.doi.org/10.1159/000501443DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6639585PMC
July 2019
5 Reads

Onychomycosis: The First to Evidence a Proximal Subungual Onychomycosis Pattern.

Case Rep Dermatol 2019 May-Aug;11(2):198-203. Epub 2019 Jul 2.

Department of Dermatology, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand.

is an emerging cause of dermatophyte infections, which are frequently isolated from hedgehogs. Nail infections from are rarely reported. We describe the case of a 23-year-old Thai female who had a history of systemic lupus erythematosus with lupus nephritis type III and who developed widespread skin and nail infections caused by that were most likely transmitted from a hedgehog. Read More

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http://dx.doi.org/10.1159/000501424DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6639565PMC
July 2019
2 Reads