630 results match your criteria Cartilage[Journal]


Caspase Inhibition Affects the Expression of Autophagy-Related Molecules in Chondrocytes.

Cartilage 2020 Jul 4:1947603520938444. Epub 2020 Jul 4.

Department of Physiology, University of Veterinary and Pharmaceutical Sciences, Brno, Czech Republic.

. Caspases, cysteine proteases traditionally associated with apoptosis and inflammation, have recently been identified as important regulators of autophagy and reported within the growth plate, a cartilaginous part of the developing bone. The aim of this research was to identify novel autophagy-related molecules affected by inhibition of pro-apoptotic caspases in chondrocytes. Read More

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http://dx.doi.org/10.1177/1947603520938444DOI Listing

Return to Work Following Arthroscopic Meniscal Allograft Transplantation.

Cartilage 2020 Jul 2:1947603520938440. Epub 2020 Jul 2.

Midwest Orthopaedics at Rush, Rush University Medical Center, Chicago, IL, USA.

Purpose: Evaluate the ability of patients to return to work (RTW) following arthroscopic meniscal allograft transplantation (MAT) for meniscal deficiency.

Methods: Consecutive patients undergoing MAT were retrospectively reviewed at a minimum of 2 years postoperatively. Patients completed a subjective work questionnaire, Visual Analogue Scale for pain, Single Assessment Numerical Evaluation, and satisfaction. Read More

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http://dx.doi.org/10.1177/1947603520938440DOI Listing

The Effect of Intraarticular Insulin on Chondral Defect Repair.

Cartilage 2020 Jul 2:1947603520938462. Epub 2020 Jul 2.

Department of Orthopaedics, School of Medicine, Istanbul University, Istanbul, Turkey.

Objective: The aim of this study is to evaluate the effects of intraarticular insulin on the treatment of chondral defects.

Design: Twenty-four mature New Zealand rabbits were randomly divided into 3 groups as control (Group 1), microfracture (Group 2), and microfracture and insulin (Group 3). Four-millimeter full-thickness cartilage defects were created to the weight-bearing surface on the medial femoral condyles of each rabbit. Read More

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http://dx.doi.org/10.1177/1947603520938462DOI Listing

Glycyrrhizin, an HMGB1 inhibitor, Suppresses Interleukin-1β-Induced Inflammatory Responses in Chondrocytes from Patients with Osteoarthritis.

Cartilage 2020 Jun 30:1947603520934858. Epub 2020 Jun 30.

Department of Emergency Surgery, the First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China.

Background: High mobility group box 1 (HMGB1) is increased in osteoarthritis (OA) tissue and chondrocytes stimulated with interleukin-1β (IL-1β). Suppression of HMGB1 expression is correlated with reduced inflammatory responses induced by IL-1β. This study aimed to investigate how inhibition of HMGB1 by glycyrrhizin might affect inflammatory responses and viability of OA patient-derived chondrocytes treated with IL-1β. Read More

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http://dx.doi.org/10.1177/1947603520934858DOI Listing

Chondral and Osteochondritis Dissecans Lesions Treated by Autologous Chondrocytes Implantation: A Mid- to Long-Term Nonrandomized Comparison.

Cartilage 2020 Jun 30:1947603520935953. Epub 2020 Jun 30.

Department of Orthopaedics and Traumatology, Helsinki University Hospital, Helsinki, Finland.

Objective: The aim of this study was to compare the clinical outcome of cartilage repair with autologous chondrocyte implantation (ACI) in patients with osteochondritis dissecans (OCD) lesions and full-thickness cartilage lesions.

Design: This study included a cohort of 115 consecutive patients with a cartilage lesion of the knee treated with ACI. Of the patients, 35 had an OCD lesion and 80 a full-thickness cartilage lesion. Read More

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http://dx.doi.org/10.1177/1947603520935953DOI Listing

Meniscal Root Tears and Extrusion Are Significantly Associated with the Development of Accelerated Knee Osteoarthritis: Data from the Osteoarthritis Initiative.

Cartilage 2020 Jun 21:1947603520934525. Epub 2020 Jun 21.

Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA, USA.

Objective: To identify joint structural risk factors, measured using quantitative compositional and semiquantitative magnetic resonance imaging (MRI) scoring, associated with the development of accelerated knee osteoarthritis (AKOA) compared with a more normal rate of knee osteoarthritis (OA) development.

Design: From the Osteoarthritis Initiative we selected knees with no radiographic OA (Kellgren-Lawrence grade [KL] 0/1) that developed advanced-stage OA (KL 3/4; AKOA) within a 4-year timeframe and a comparison group with a more normal rate of OA development (KL 0/1 to KL 2 in 4 years). MRIs at the beginning of the 4-year timeframe were assessed for cartilage T2 values and structural abnormalities using a modified Whole-Organ Magnetic Resonance Imaging Score (WORMS). Read More

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http://dx.doi.org/10.1177/1947603520934525DOI Listing

Optimization and Validation of a Human Femoral Head Model for Preclinical Cartilage Research and Regenerative Therapies.

Cartilage 2020 Jun 21:1947603520934534. Epub 2020 Jun 21.

Biomedical Sciences, Edinburgh Medical School, University of Edinburgh, Edinburgh, Scotland, UK.

Objective: Articular cartilage is incapable of effective repair following injury or during osteoarthritis. While there have been developments in cartilage repair technologies, there is a need to advance biologically relevant models for preclinical testing of biomaterial and regenerative therapies. This study describes conditions for the effective culture of the whole human femoral head. Read More

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http://dx.doi.org/10.1177/1947603520934534DOI Listing

PRP Injections for the Treatment of Knee Osteoarthritis: A Meta-Analysis of Randomized Controlled Trials.

Cartilage 2020 Jun 19:1947603520931170. Epub 2020 Jun 19.

IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy.

Objective: To evaluate effectiveness, in terms of patient-reported outcome measures, of platelet-rich plasma (PRP) injections for knee osteoarthritis compared to placebo and other intraarticular treatments.

Design: PubMed, Cochrane Library, Scopus, Embase, Web of Science, as well as the gray literature were searched on January 17, 2020. Randomized controlled trials (RCTs) comparing PRP injections with placebo or other injectable treatments, in any language, on humans, were included. Read More

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http://dx.doi.org/10.1177/1947603520931170DOI Listing

Low-Frequency Vibration Promotes Tumor Necrosis Factor-α Production to Increase Cartilage Degeneration in Knee Osteoarthritis.

Cartilage 2020 Jun 12:1947603520931178. Epub 2020 Jun 12.

West China Hospital, Sichuan University, Chengdu, Sichuan, People's Republic of China.

Objective: Low-frequency vibration accelerates cartilage degeneration in knee osteoarthritis (KOA) rat model. In this article, we investigated whether whole-body vibration (WBV) increases cartilage degeneration by regulating tumor necrosis factor-α (TNF-α) in KOA.

Design: Proteomics analysis was used to filter candidate protein from synovial fluid (SF) in KOA people after WBV. Read More

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http://dx.doi.org/10.1177/1947603520931178DOI Listing

Dickkopf-3 (DKK3) Signaling in IL-1α-Challenged Chondrocytes: Involvement of the NF-κB Pathway.

Cartilage 2020 Jun 12:1947603520933328. Epub 2020 Jun 12.

SERGAS (Servizo Galego de Saude) and IDIS (Instituto de Investigación Sanitaria de Santiago), the NEIRID Lab (Neuroendocrine Interactions in Rheumatology and Inflammatory Diseases), Santiago University Clinical Hospital, Santiago de Compostela, Spain.

Objective: Osteoarthritis (OA) is an age-related biomechanical and low-grade inflammometabolic disease of the joints and one of the costliest and disabling forms of arthritis. Studies on matrix-degrading enzymes such as metalloproteases, which are implicated in the increased catabolism of extracellular matrix, are of paramount relevance. DKK3 is a member of DKK family and is best known for its role in cancer. Read More

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http://dx.doi.org/10.1177/1947603520933328DOI Listing

The Response of Hip Joint Cartilage to Exercise in Children: An MRI Study Using T2-Mapping.

Cartilage 2020 Jun 12:1947603520931182. Epub 2020 Jun 12.

Botnar Research Centre, Nuffield Department of Orthopaedics, Rheumatology, and Musculoskeletal Sciences, University of Oxford, Oxford, UK.

Objective: The aim of this study was to determine the effects of activity and cam morphology on cartilage composition during adolescence and investigate the development of cartilage composition with age.

Design: Cross-sectional observational cohort study of individuals from football club academies and an age-matched control population, aged 9 to 18 years. Assessments included questionnaires and T2-mapping of hips. Read More

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http://dx.doi.org/10.1177/1947603520931182DOI Listing

Is Laminar Cartilage Composition as Determined by T2 Relaxometry Associated with Incident and Worsening of Cartilage or Bone Marrow Abnormalities?

Cartilage 2020 Jun 12:1947603520932197. Epub 2020 Jun 12.

Chondrometrics GmbH, Ainring, Germany.

Objective: To test the hypothesis that superficial cartilage composition (T2) is associated with subsequent incidence or worsening of cartilage damage, and deep T2 with that of bone marrow lesions (BMLs) in knees without radiographic osteoarthritis (ROA).

Design: A total of 201 knees from the Osteoarthritis Initiative without ROA were included: 78 from the healthy reference cohort, 60 without ROA but with risk factors, and 63 without ROA but with contralateral ROA. Year 1 (Y1) superficial and deep cartilage T2 were derived in the medial and lateral (weightbearing) femur (MF/LF) and tibia (MT/LT), using sagittal multiecho spin echo magnetic resonance images. Read More

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http://dx.doi.org/10.1177/1947603520932197DOI Listing

Altered Expression of Aggrecan, FAM20B, B3GALT6, and EXTL2 in Patients with Osteoarthritis and Kashin-Beck Disease.

Cartilage 2020 Jun 9:1947603520932199. Epub 2020 Jun 9.

School of Public Health, Key Laboratory of Environment and Genes Related to Diseases, Health Science Center, Xi'an Jiaotong University, Xi'an, Shaanxi, People's Republic of China.

Objective: The objective of this study was to investigate the expression of enzymes involved in synthesis and modification of chondroitin sulfate (CS) in knee cartilage tissue of patients with osteoarthritis (OA) and Kashin-Beck disease (KBD).

Methods: The knee articular cartilage samples were obtained from 18 age- and gender-matched donors with 6 each in KBD, OA, and control groups. Hematoxylin and eosin (HE) staining, toluidine blue (TB) staining, and immunohistochemical (IHC) staining were performed to estimate the expression level and localization of aggrecan, along with FAM20B, GalT-II, and EXTL2, which are associated with CS synthesis and modification. Read More

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http://dx.doi.org/10.1177/1947603520932199DOI Listing

Pain and Functional Scores in Patients Affected by Knee OA after Treatment with Pulsed Electromagnetic and Magnetic Fields: A Meta-Analysis.

Cartilage 2020 Jun 8:1947603520931168. Epub 2020 Jun 8.

IRCCS Istituto Ortopedico Galeazzi, Milano, Italy.

Objective: The purpose of this systematic review and meta-analysis was to evaluate the effect of electromagnetic field treatment on the symptoms of knee osteoarthritis (OA). In addition, the influence of the type of control group and other covariates have been investigated to identify the sources of heterogeneity in the results of the available clinical trials.

Methods: Randomized controlled trials reporting pulsed electromagnetic field-based therapies for the treatment of knee OA have been included. Read More

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http://dx.doi.org/10.1177/1947603520931168DOI Listing

Non-invasive Electroarthrography Measures Load-Induced Cartilage Streaming Potentials via Electrodes Placed on Skin Surrounding an Articular Joint.

Cartilage 2020 Jun 5:1947603520928583. Epub 2020 Jun 5.

Comparative Orthopaedic Research Laboratory, Department of Clinical Studies, University of Guelph, Guelph, Ontario, Canada.

Objective: We aimed to demonstrate that electroarthrography (EAG) measures streaming potentials originating in the cartilage extracellular matrix during load bearing through electrodes adhered to skin surrounding an articular joint.

Design: Equine metacarpophalangeal joints were subjected to simulated physiological loads while (1) replacing synovial fluid with immersion buffers of different electrolyte concentrations and (2) directly degrading cartilage with trypsin.

Results: An inverse relationship between ionic strength and EAG coefficient was detected. Read More

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http://dx.doi.org/10.1177/1947603520928583DOI Listing

High and Varied Anterior Condyle of the Distal Femur Is Associated with Limited Flexion in Varus Knee Osteoarthritis.

Cartilage 2020 Jun 4:1947603520928582. Epub 2020 Jun 4.

Department of Orthopaedic Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

Objective: This study aimed to evaluate variations in anterior condylar height (ACH) of the distal femur in varus knee osteoarthritis and evaluate the association between ACH and knee flexion.

Design: Computed tomography (CT) images of 171 knees (143 patients; age 73.7 ± 8. Read More

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http://dx.doi.org/10.1177/1947603520928582DOI Listing

Chondral and Osteochondral Femoral Cartilage Lesions Treated with GelrinC: Significant Improvement of Radiological Outcome Over Time and Zonal Variation of the Repair Tissue Based on T Mapping at 24 Months.

Cartilage 2020 Jun 4:1947603520926702. Epub 2020 Jun 4.

High Field MR Center, Department of Biomedical Imaging and Image-Guided Therapy, CD Laboratory for Clinical Molecular MR Imaging, Medical University of Vienna, Vienna, Austria.

Objective: To prospectively assess the efficacy of GelrinC in the treatment of chondral and osteochondral femoral cartilage lesions using morphological (Magnetic Resonance Observation of Cartilage Repair Tissue [MOCART]) and quantitative (T-mapping) magnetic resonance imaging (MRI).

Design: This study was designed as a prospective single-arm, open label, multicenter study. Morphological magnetic resonance imaging (MRI) for MOCART assessment and T mapping was performed 1 week and 6, 12, 18, and 24 months after GelrinC implantation. Read More

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http://dx.doi.org/10.1177/1947603520926702DOI Listing

Mesenchymal Stromal Cell Transplantation Induces Regeneration of Large and Full-Thickness Cartilage Defect of the Temporomandibular Joint.

Cartilage 2020 Jun 4:1947603520926711. Epub 2020 Jun 4.

Unidad de Terapia Celular, Laboratorio de Patología Celular y Molecular, Instituto Venezolano de Investigaciones Científicas (IVIC), Caracas, Miranda, Venezuela.

Objective: Cartilage damage (CD) in the temporomandibular joint (TMJ) continues being a major problem in maxillofacial field. Evidence suggests that cellular therapy may be used for repairing CD in the TMJ.

Design: A murine model of condyle CD (CCD) was generated in the TMJ to evaluate the capacity of mesenchymal stromal cells (MSCs) to induce cartilage regeneration in CCD. Read More

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http://dx.doi.org/10.1177/1947603520926711DOI Listing

Does Gender Influence Outcome in Cartilage Repair Surgery? An Analysis of 4,968 Consecutive Patients from the German Cartilage Registry (Knorpel Register DGOU).

Cartilage 2020 Jun 1:1947603520923137. Epub 2020 Jun 1.

OCM-Orthopädische Chirurgie München, Munich, Germany.

The goal was to examine gender differences of patient characteristics and outcome after cartilage repair based on a collective of nearly 5,000 patients. Patient characteristics, accompanying therapies, and outcome (Knee Injury and Osteoarthritis Outcome Score [KOOS], reoperations, patient satisfaction) of 4,986 patients of the German cartilage register DGOU were assessed by test for possible gender differences. values <0. Read More

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http://dx.doi.org/10.1177/1947603520923137DOI Listing

Costal Chondrocyte-Derived Pellet-Type Autologous Chondrocyte Implantation versus Microfracture for Repair of Articular Cartilage Defects: A Prospective Randomized Trial.

Cartilage 2020 Jun 1:1947603520921448. Epub 2020 Jun 1.

Department of Orthopaedic Surgery, Kyung-Hee University Hospital, Seoul, Republic of Korea.

Objective: To compare the efficacy and safety of costal chondrocyte-derived pellet-type autologous chondrocyte implantation (CCP-ACI) with microfracture (MFx) for repair of articular cartilage defects of the knee.

Design: Thirty subjects with an International Cartilage Repair Society (ICRS) grade 3 to 4 chondral defect (2-10 cm in area; ≤4 cm in volume) were randomized at a ratio of 2:1 (CCP-ACI:MFx). Twenty patients were allocated in the CCP-ACI group and 10 patients in the MFx group. Read More

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http://dx.doi.org/10.1177/1947603520921448DOI Listing

Aging Cartilage in Wild-Type Mice: An Observational Study.

Cartilage 2020 Jun 1:1947603520926713. Epub 2020 Jun 1.

INSERM UMRS 1124, Toxicité Environnementale, Cibles Thérapeutiques, Signalisation Cellulaire et Biomarqueurs (T3S), Campus Saint-Germain-des-Prés, Paris, France.

Objective: To describe the spontaneous evolution of age-related changes affecting knee joint articular cartilage, walking speed and a serum biomarker of cartilage remodeling in C57BL/6-JRj wild-type male mice.

Design: Histological changes were assessed by the Osteoarthritis Research Society International (OARSI) score (0=normal, 6=vertical clefts/erosion to the calcified cartilage extending >75% of the articular surface) in newborn, 1-week- and 1-, 3-, 6-, 9- and 12-month-old C57BL/6-JRj wild-type male mice, walking speed by the Locotronic system, and serum C-terminal telopeptide of type II collagen (CTX-II) content by ELISA in 1-, 3-, 6-, and 9-month-old C57BL/6-JRj wild-type male mice.

Results: Mean (SD) OARSI score significantly increased from 0. Read More

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http://dx.doi.org/10.1177/1947603520926713DOI Listing

Complex Meniscus Tears Treated with Collagen Matrix Wrapping and Bone Marrow Blood Injection: Clinical Effectiveness and Survivorship after a Minimum of 5 Years' Follow-Up.

Cartilage 2020 Jun 1:1947603520924762. Epub 2020 Jun 1.

Rehasport Clinic, Poznań, Poland.

. To determine the 5-year success rate of the "all-inside" technique of arthroscopic meniscus suture and collagen membrane wrapping along with bone marrow blood injection, to evaluate the progression of degenerative changes and the impact of simultaneous anteriro cruciate ligament (ACL) reconstruction. . Read More

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http://dx.doi.org/10.1177/1947603520924762DOI Listing

Properties of Cartilage-Subchondral Bone Junctions: A Narrative Review with Specific Focus on the Growth Plate.

Cartilage 2020 May 27:1947603520924776. Epub 2020 May 27.

Biomedical Engineering Department, University of Memphis, Memphis, TN, USA.

Objective: The purpose of this narrative review is to summarize what is currently known about the structural, chemical, and mechanical properties of cartilage-bone interfaces, which provide tissue integrity across a bimaterial interface of 2 very different structural materials. Maintaining these mechanical interfaces is a key factor for normal bone growth and articular cartilage function and maintenance.

Materials And Methods: A comprehensive search was conducted using Google Scholar and PubMed/Medline with a specific focus on the growth plate cartilage-subchondral bone interface. Read More

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http://dx.doi.org/10.1177/1947603520924776DOI Listing

Anionic Contrast-Enhanced MicroCT Imaging Correlates with Biochemical and Histological Evaluations of Osteoarthritic Articular Cartilage.

Cartilage 2020 May 26:1947603520924748. Epub 2020 May 26.

Department of Clinical Studies, Ontario Veterinary College, University of Guelph, Guelph, Ontario, Canada.

This study addressed difficulties in evaluating osteoarthritis (OA) progression in species with thin cartilage. Feasibility of using short, nonequilibrium contrast-enhanced micro-computed tomography (CE-μCT) to evaluate the physical and biochemical properties of cartilage was investigated. A preliminary study using CE-μCT study was performed using bovine osteochondral blocks with intact, mildly damaged (fibrillated), or severely damaged (delaminated) cartilage. Read More

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http://dx.doi.org/10.1177/1947603520924748DOI Listing

Regions at Risk in the Knee Joint of Young Professional Soccer Players: Longitudinal Evaluation of Early Cartilage Degeneration by Quantitative T2 Mapping in 3 T MRI.

Cartilage 2020 May 25:1947603520924773. Epub 2020 May 25.

Friedrich-Alexander University Erlangen-Nürnberg (FAU), Erlangen, Germany.

. The study aims to detect regions at risk for (pre-)osteoarthritis in the tibiofemoral joint of young professional soccer players by evaluating cartilage composition by T2 mapping in a 3 T magnetic resonance imaging setting. . Read More

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http://dx.doi.org/10.1177/1947603520924773DOI Listing

Return to Sport following Isolated Lateral Opening Wedge Distal Femoral Osteotomy.

Cartilage 2020 May 25:1947603520924775. Epub 2020 May 25.

Midwest Orthopaedics at Rush University Medical Center, Chicago, IL, USA.

. The aims of this study were to (1) examine the timeline of return to sport (RTS) following isolated lateral opening wedge distal femoral osteotomy (DFO), (2) evaluate the degree of participation on RTS, and (3) identify risk factors for failure to RTS. . Read More

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http://dx.doi.org/10.1177/1947603520924775DOI Listing

Biomechanical Changes of Repair Tissue after Autologous Chondrocyte Implantation at Long-Term Follow-Up.

Cartilage 2020 May 23:1947603520921433. Epub 2020 May 23.

Department of Orthopaedics and Traumatology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.

. This study aims to describe biomechanical maturation process of repair tissue after cartilage repair with autologous chondrocyte implantation (ACI) at long-term follow-up. . Read More

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http://dx.doi.org/10.1177/1947603520921433DOI Listing

Increased Vascularity in the Neonatal versus Adult Meniscus: Evaluation with Magnetic Resonance Imaging.

Cartilage 2020 May 23:1947603520923143. Epub 2020 May 23.

Miami Orthopedics and Sports Medicine Institute, Baptist Health South Florida, Miami, FL, USA.

. Quantification of meniscus vascularity has been limited with previous techniques, and minimal data exist describing differential vascular zones in the skeletally immature meniscus. The objective of this study is to use quantitative contrast-enhanced magnetic resonance imaging (MRI) to compare meniscal vascularity in neonatal specimens with adults. Read More

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http://dx.doi.org/10.1177/1947603520923143DOI Listing

Disturbances in Metabolic Pathways and the Identification of a Potential Biomarker Panel for Early Cartilage Degeneration in a Rabbit Anterior Cruciate Ligament Transection Model.

Cartilage 2020 May 22:1947603520921434. Epub 2020 May 22.

Department of Radiology & Institute of Medical Functional and Molecular Imaging, Huashan Hospital, Fudan University, Shanghai, China.

Objective: This study aimed to assess the association between synovial fluid (SF) metabolites and magnetic resonance imaging (MRI) measurements of cartilage biochemical composition to identify potential SF biomarkers for detecting the early onset of cartilage degeneration in a rabbit model.

Methods: Both knees of 12 New Zealand White rabbits were used. The anterior cruciate ligament transection (ACLT) model was performed on right knees, and the sham surgery on left knees. Read More

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http://dx.doi.org/10.1177/1947603520921434DOI Listing

Chondroitinase ABC Enhances Integration of Self-Assembled Articular Cartilage, but Its Dosage Needs to Be Moderated Based on Neocartilage Maturity.

Cartilage 2020 May 22:1947603520918653. Epub 2020 May 22.

Department of Biomedical Engineering, University of California, Irvine, CA, USA.

Objective: To enhance the integration of self-assembled articular cartilage to native articular cartilage using chondroitinase ABC.

Design: To examine the hypothesis that chondroitinase ABC (C-ABC) integration treatment (C-ABC) would enhance integration of neocartilage of different maturity levels, this study was conducted in 2 phases. In phase I, the impact on integration of 2 treatments, TCL (TGF-β1, C-ABC, and lysyl oxidase like 2) and C-ABC, was examined via a 2-factor, full factorial design. Read More

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http://dx.doi.org/10.1177/1947603520918653DOI Listing

Outcomes of Partial Meniscectomy in Obese Patients: A Systematic Review and Meta-Analysis.

Cartilage 2020 May 20:1947603520923025. Epub 2020 May 20.

Department of Orthopaedics, University of Maryland School of Medicine, Baltimore, MD, USA.

Objective: Arthroscopic partial meniscectomy (APM) is one of the most commonly performed surgical procedures. However, the indications for APM are controversial and obese patients may have worse outcomes. This study's primary purpose was to investigate differences in outcome after APM associated with elevated body mass index (BMI). Read More

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http://dx.doi.org/10.1177/1947603520923025DOI Listing

Comparison of Human Platelet Lysate versus Fetal Bovine Serum for Expansion of Human Articular Cartilage-Derived Chondroprogenitors.

Cartilage 2020 May 14:1947603520918635. Epub 2020 May 14.

Department of Physiology, Christian Medical College, Vellore, Tamil Nadu, India.

Purpose: Articular chondroprogenitors, a suitable contender for cell-based therapy in cartilage repair, routinely employ fetal bovine serum (FBS) for expansion and differentiation. The possibility of transplant rejections or zoonoses transmissions raise a need for xeno-free alternatives. Use of human platelet lysate (hPL), a nutrient supplement abundant in growth factors, has not been reported for human chondroprogenitor expansion thus far. Read More

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http://dx.doi.org/10.1177/1947603520918635DOI Listing

Arthroscopic Matrix-Encapsulated Autologous Chondrocyte Implantation: A Pilot Multicenter Investigation in Latin America.

Cartilage 2020 May 14:1947603520918630. Epub 2020 May 14.

Instituto Nacional de Rehabilitación Luis Guillermo Ibarra Ibarra, Mexico City, DF, Mexico.

. To evaluate minimum biosecurity parameters (MBP) for arthroscopic matrix-encapsulated autologous chondrocyte implantation (AMECI) based on patients' clinical outcomes, magnetic resonance imaging (MRI) T2-mapping, Magnetic Resonance Observation of Cartilage Repair Tissue (MOCART) score, and International Cartilage Repair Society (ICRS) second-look arthroscopic evaluation, laying the basis for a future multicenter study. . Read More

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http://dx.doi.org/10.1177/1947603520918630DOI Listing

Osteochondral Autograft Plugs versus Paste Graft: Morselization Increases Chondral Matrix Production.

Cartilage 2020 May 12:1947603520916552. Epub 2020 May 12.

Stone Research Foundation, San Francisco, CA, USA.

Objective: Patients undergoing articular cartilage paste grafting have been shown in studies to have significant improvement in pain and function in long-term follow-ups. We hypothesized that impacting of osteochondral autografts results in higher chondrocyte matrix production versus intact osteochondral autograft plugs.

Design: This institutional review board-approved study characterizes the effects of impacting osteochondral plugs harvested from the intercondylar notch of 16 patients into a paste, leaving one graft intact as a control. Read More

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http://dx.doi.org/10.1177/1947603520916552DOI Listing

Assessment of the Degree of Osteoarthritis in Aging Male and Female Femoral Condyles: A Cadaveric Study.

Cartilage 2020 May 12:1947603520916530. Epub 2020 May 12.

Departments of Natural Sciences & Mathematics and Graduate Health Sciences, West Liberty University, West Liberty, WV, USA.

Objective: Determine if femoral chondral cartilage degeneration on cadaveric knee joints exacerbate differently with aging between the sexes.

Methods: A total of 85 cadaveric femurs were assessed for macroscopic femoral condyle pathology using a scale for gross signs of osteoarthritis. Raters scored specimens and raters' scores were averaged to provide each specimen a Disease Severity Score (DSS). Read More

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http://dx.doi.org/10.1177/1947603520916530DOI Listing

Increase in Free and Total Plasma TGF-β1 Following Physical Activity.

Cartilage 2020 Apr 27:1947603520916523. Epub 2020 Apr 27.

Department of Medicine, Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC, USA.

Objective: To evaluate effects of physical activity and food consumption on plasma concentrations of free and total transforming growth factor beta-1 (TGF-β1), beta-2 (TGF-β2), and beta-3 (TGF-β3) in individuals with knee osteoarthritis (OA).

Methods: Participants ( = 40 in 2 cohorts of 20; mean age 70 years) with radiographic knee OA were admitted overnight for serial blood sampling. Cohorts 1 and 2 assessed the impacts of food intake and activity, respectively, on TGF-β concentrations. Read More

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http://dx.doi.org/10.1177/1947603520916523DOI Listing

Return to Work Following Tibial Tubercle Osteotomy for Patellofemoral Osteoarthritis and Pain.

Cartilage 2020 Apr 22:1947603520916544. Epub 2020 Apr 22.

Department of Orthopedic Surgery, Hospital for Special Surgery, New York, NY, USA.

Purpose: To evaluate the ability of patients to return to work following anteromedialization (AMZ) tibial tubercle osteotomy (TTO) due to isolated patellofemoral osteoarthritis or pain.

Methods: Consecutive patients undergoing AMZ TTO were reviewed retrospectively at a minimum of 1 year postoperatively. Patients completed a subjective work questionnaire, a visual analog scale for pain, as well as a Kujala questionnaire and satisfaction questionnaire. Read More

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http://dx.doi.org/10.1177/1947603520916544DOI Listing

Low-Intensity Pulsed Ultrasound Alleviates Osteoarthritis Condition Through Focal Adhesion Kinase-Mediated Chondrocyte Proliferation and Differentiation.

Cartilage 2020 Apr 13:1947603520912322. Epub 2020 Apr 13.

Department of Orthopaedics, Wujin Hospital Affiliated with Jiangsu University, the Wujin Clinical College of Xuzhou Medical University, Changzhou, Jiangsu, China.

Objective: Osteoarthritis (OA) is a prevalent chronic multifactorial degenerative disease characterized by joint tissue inflammation, osteophyte formation, subchondral bone sclerosis, and articular cartilage degradation. Low-intensity pulsed ultrasound (LIPUS), a noninvasive ultrasound technique, is widely used to attenuate diseases. The aim of this study was to investigate whether LIPUS can ameliorate OA, and to explore its underlying molecular mechanism. Read More

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http://dx.doi.org/10.1177/1947603520912322DOI Listing

2019 Reviewer Thank You.

Authors:

Cartilage 2020 Apr;11(2):262-263

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http://dx.doi.org/10.1177/1947603520909036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7097976PMC

TNIIIA2, The Peptide of Tenascin-C, as a Candidate for Preventing Articular Cartilage Degeneration.

Cartilage 2020 Mar 23:1947603520912300. Epub 2020 Mar 23.

Department of Orthopaedic Surgery, Mie University Graduate School of Medicine, Tsu City, Mie, Japan.

Objective: TNIIIA2 is a peptide of the extracellular matrix glycoprotein tenascin-C. We evaluated whether intra-articular injection of TNIIIA2 could prevent articular cartilage degeneration without inducing synovitis in an osteoarthritis mice model.

Design: Ten micrograms per milliliter of TNIIIA2 were injected into the knee joint of mice (group II) to evaluate the induction of synovitis. Read More

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http://dx.doi.org/10.1177/1947603520912300DOI Listing

Clinical Outcomes after Arthroscopic Treatment of Synovial Chondromatosis in the Hip.

Cartilage 2020 Mar 20:1947603520912316. Epub 2020 Mar 20.

Institute of Sports Medicine, Peking University Third Hospital, Beijing, China.

Purpose: Evaluate the clinical outcomes after arthroscopic treatment of synovial chondromatosis (SC) of the hip.

Materials And Methods: We evaluated patients who underwent arthroscopic management for SC of the hip from November 2008 to March 2017. Radiographic evaluation was made before and after surgery. Read More

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http://dx.doi.org/10.1177/1947603520912316DOI Listing

The Long-Lasting Effects of "Placebo Injections" in Knee Osteoarthritis: A Meta-Analysis.

Cartilage 2020 Mar 18:1947603520906597. Epub 2020 Mar 18.

Orthopaedic and Traumatology Unit, Ospedale Regionale di Lugano, EOC, Lugano, Ticino, Switzerland.

Objectives: To quantify the placebo effect of intraarticular injections for knee osteoarthritis in terms of pain, function, and objective outcomes. Factors influencing placebo effect were investigated.

Design: Meta-analysis of randomized controlled trials; Level of evidence, 2. Read More

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http://dx.doi.org/10.1177/1947603520906597DOI Listing

The Viability and Anti-Inflammatory Effects of Hyaluronic Acid-Chitlac-Tracimolone Acetonide-β-Cyclodextrin Complex on Human Chondrocytes.

Cartilage 2020 Feb 28:1947603520908658. Epub 2020 Feb 28.

Department of Molecular Medicine, Histology Unit, University of Padova, Padova, Italy.

Objective: To compare the effects of the complex triamcinolone acetonide-hydroxypropyl-β-cyclodextrin (TA-CD) on inflamed primary human articular chondrocytes in the presence or absence of the mixture hyaluronic acid-Chitlac, a lactose-modified chitosan (HA-CTL).

Design: Changes in cell viability and pro-inflammatory cytokines gene expression were analyzed in human chondrocytes using an model of macrophage-mediated inflammation. Human monocytes U937 were differentiated to macrophages by phorbol 12-myristate 13-acetate (PMA) and lipopolysaccharides (LPS). Read More

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http://dx.doi.org/10.1177/1947603520908658DOI Listing
February 2020

Influence of Glucose Concentration on Colony-Forming Efficiency and Biological Performance of Primary Human Tissue-Derived Progenitor Cells.

Cartilage 2020 Feb 26:1947603520906605. Epub 2020 Feb 26.

Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.

Objective: Glucose concentrations used in current cell culture methods are a significant departure from physiological glucose levels. The study focuses on comparing the effects of glucose concentrations on primary human progenitors (connective tissue progenitors [CTPs]) used for cartilage repair.

Design: Cartilage- (Outerbridge grade 1, 2, 3; superficial and deep zone cartilage), infrapatellar fatpad-, synovium-, and periosteum-derived cells were obtained from 63 patients undergoing total knee arthroplasty and cultured simultaneously in fresh chondrogenic media containing 25 mM glucose (HGL) or 5 mM glucose (NGL) for pairwise comparison. Read More

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http://dx.doi.org/10.1177/1947603520906605DOI Listing
February 2020

Special Spine issue introduction.

Cartilage 2020 Apr 20;11(2):141-142. Epub 2020 Feb 20.

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http://dx.doi.org/10.1177/1947603520909017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7097977PMC

Synovial Adiponectin Was More Associated with Clinical Severity than Synovial Leptin in Women with Knee Osteoarthritis.

Cartilage 2020 Feb 20:1947603520904776. Epub 2020 Feb 20.

Rheumatology Department, Parc Taulí University Hospital, Sabadell, Barcelona, Spain.

Objective: Different adipokines have been reported to play a role in the development, progression, and severity of knee osteoarthritis, but this association may be mediated by obesity. The aim of this study was to evaluate separately the associations of leptin and adiponectin with clinical severity and inflammatory markers in nonobese and obese women with knee osteoarthritis.

Design: Cross-sectional study with systematic inclusion of 115 women with symptomatic primary knee osteoarthritis. Read More

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http://dx.doi.org/10.1177/1947603520904776DOI Listing
February 2020

The First Report of the International Cartilage Regeneration and Joint Preservation Society's Global Registry.

Cartilage 2020 Feb 19:1947603520907664. Epub 2020 Feb 19.

Trauma and Orthopaedic Surgery, University Hospital Aintree Teaching Hospital Major Trauma Centre Foundation Trust, Longmoor Lane, Liverpool, UK.

Objective: The International Cartilage Regeneration and Joint Preservation Society's (ICRS's) global registry, aims to be the best source of information for patients and an unbiased resource of evidence-based medicine for scientists and clinicians working to help those unfortunate enough to suffer the pain and disability associated with articular cartilage lesions. This article constitutes the scientific summary of the reports' main findings.

Design: The article outlines the historical precedents in the development of orthopedic registries from the earliest tumor registries, then local arthroplasty databases that led ultimately to international collaborations between national arthroplasty and soft tissue registries. Read More

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http://dx.doi.org/10.1177/1947603520907664DOI Listing
February 2020

Current Treatment Options for Intervertebral Disc Pathologies.

Cartilage 2020 Apr 19;11(2):143-151. Epub 2020 Feb 19.

Robert Jones and Agnes Hunt Orthopaedic Hospital NHS Foundation Trust, Oswestry, Shropshire, UK.

The complex structure of the intervertebral disc within the spine is well suited to its mechanical function. However, it is also prone to degeneration, which is associated with various clinical symptoms and conditions, ranging from disc herniation to back pain to spinal stenosis. Most patients' conditions are managed conservatively but a small proportion progress to having surgery. Read More

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http://dx.doi.org/10.1177/1947603520907665DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7097980PMC

Platelet-Rich Plasma for Knee Osteoarthritis: Internet Marketing and Patient Education-An Appraisal of Content for Websites with the Greatest Search Engine Visibility.

Cartilage 2020 Feb 19:1947603520906598. Epub 2020 Feb 19.

Department of Orthopedic Surgery, Beilinson Campus, Rabin Medical Center, Petah-Tikva, Israel.

Objective: The internet is increasingly being used as a resource for health-related information by the general public. We sought to establish the authorship, content, and accuracy of the information available online regarding platelet-rich plasma (PRP) therapy for knee osteoarthritis.

Design: Top 200 search results from each of the 3 leading search engines available online (Google, Yahoo!, Bing) were screened, and 181 websites were finally reviewed for content with emphasis on specific claims, comparing between websites authored by private physicians/groups and other authorship types. Read More

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http://dx.doi.org/10.1177/1947603520906598DOI Listing
February 2020