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Rev Neurosci 2019 Feb 15. Epub 2019 Feb 15.

Department of Traditional Pharmacy, School of Persian Medicine, Tehran University of Medical Sciences, Tehran 14167-53955, Iran.

Neuropathy is defined as the damage to the peripheral or central nervous system accompanied by pain, numbness, or muscle weakness, which can be due to congenital diseases or environmental factors such as diabetes, trauma, or viral infections. As current treatments are not sufficiently able to control the disease, studies focusing on the identification and discovery of new therapeutic agents are necessary. Natural products have been used for a long time for the management of different neurological problems including neuropathies. Read More

Biomedicines 2019 Feb 5;7(1). Epub 2019 Feb 5.

Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya 466-8550, Japan.

Transthyretin (TTR) amyloidosis is caused by systemic deposition of wild-type or variant amyloidogenic TTR (ATTRwt and ATTRv, respectively). ATTRwt amyloidosis has traditionally been termed senile systemic amyloidosis, while ATTRv amyloidosis has been called familial amyloid polyneuropathy. Although ATTRwt amyloidosis has classically been regarded as one of the causes of cardiomyopathy occurring in the elderly population, recent developments in diagnostic techniques have significantly expanded the concept of this disease. Read More

Eur J Case Rep Intern Med 2018 27;5(9):000926. Epub 2018 Sep 27.

Department of Internal Medicine, State University of Medicine and Pharmacy "Nicolae Testemiţanu", Chisinau, Republic of Moldova.

This case report describes an unusual form of gout, called miliarial gout, in association with carpal tunnel syndrome in a 54-year-old woman. Miliarial gout was first described in 2007 and is a very rare presentation of chronic tophaceous gout. The latter condition can cause carpal tunnel syndrome, but this association has not previously been described in association with miliarial gout. Read More

Cas Lek Cesk 2019 ;157(8):396-399

The causes of occupational diseases are changing, thats why a regular update of Czech List of Occupational Diseases is needed. New compensable occupational diseases, such as cancer of the larynx and ovarian cancer due to asbestos, and chronic obstructive pulmonary diseases due to black coal dust were included in the last two updates of the Czech List. The need of an early examination at the Centers of Occupational Diseases is stressed in this article, especially before a surgery or other treatment of epicondylitis and carpal tunnel syndrome. Read More

J Am Podiatr Med Assoc 2018 Nov;108(6):532-534

Metatarsalgia is characterized by pain in the forefoot, which is associated with increased stress over the metatarsal head region. Despite the availability of a variety of conservative or surgical treatments for this condition, a few cases have demonstrated relapse or poor response to treatment. Pulsed radiofrequency (PRF) can provide pain relief in patients with diverse chronic conditions without causing neural injury. Read More

J Surg Res 2019 Feb 7;238:64-71. Epub 2019 Feb 7.

Division of Plastic and Reconstructive Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts. Electronic address:

Background: Spanish-speaking Hispanics living in the United States utilize the internet as a primary means to obtain health information. Accurate, accessible information is important for English speakers; however, it could have even greater utility for Spanish speakers who have lower health literacy levels. The aim of this study was to evaluate and compare online English and Spanish carpal tunnel surgery materials provided by using a multimetric approach. Read More

PM R 2019 Feb 7. Epub 2019 Feb 7.

Division of Physical Medicine and Rehabilitation, Department of Medicine, University of Toronto, Toronto.

Background: Carpal tunnel syndrome (CTS) is the most common entrapment mono-neuropathy of the median nerve. In comparison to open surgical and endoscopic carpal tunnel release, a new ultrasound guided hook knife carpal tunnel release (CTR) procedure was reported to have superior results in terms of reduced morbidity and early return to work.

Objective: To evaluate the reproducibility of the hook knife CTR procedure when performed by musculoskeletal ultrasound trained physicians without a prior experience in this technique. Read More

Can J Neurol Sci 2019 Feb 6:1-5. Epub 2019 Feb 6.

Department of Neurology,Memorial University of Newfoundland,St. John's, Newfoundland,Canada.

Introduction: Lewis-Sumner syndrome (LSS) is a demyelinating peripheral neuropathy described in 1982.

Methods: We reviewed the charts of nine LSS patients in neurological care for their symptoms, response to different treatment regimens, and pattern of nerve involvement.

Results: One patient had an Adie's pupil. Read More

Acta Biomed 2018 Dec 20;90(1-S):158-161. Epub 2018 Dec 20.

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Background And Aim Of The Work: Hypothenar Hammer Syndrome is a relatively rare disease process caused by repetitive stress or injury to the hypothenar eminence leading to chronic injury to the ulnar artery. Our study reports an unusual case.

Methods: A 57 years old Plumber presented in April 2016 with a history of constant pain and recurrent paresthesia involving the fingers of the right hand for several months, over the previous 1 year, his hand had become more intolerant of exposure to cold temperatures. Read More

J Tissue Eng Regen Med 2019 Feb 1. Epub 2019 Feb 1.

Department of Physical and Rehabilitation Medicine, Hacettepe University Medical School, Ankara, Turkey.

PRP treatment has a potential to become a part of non-surgical approach in CTS as a regenerative method. Platelet-rich plasma (PRP) therapies aim to enhance the self-healing ability of human body, by exposing the injured tissue to a high concentration of autologous growth factors. Nerve tissues also seem to benefit from the regenerative effects of PRP concentrates. Read More

Acta Orthop Traumatol Turc 2019 Jan 28. Epub 2019 Jan 28.

Maslak Acibadem Hospital, Orthopedics and Traumatology Department, İstanbul, Turkey. Electronic address:

Metaplastic synovial cyst (MSC) is a benign cystic lesion observed after surgical intervention and recurrent skin trauma. Because of its rarity, the etiology is not fully understood. The most emphasized etiologic factors are recurrent surgical procedures and cutaneous pathologies, which cause cutaneous fragility and abnormal wound formation. Read More

Med Clin North Am 2019 Mar;103(2):357-370

Department of Neurology, Massachusetts General Hospital, 55 Fruit Street, WACC 739B, Boston, MA 02114, USA. Electronic address:

Upper extremity entrapment neuropathies are common and can cause pain, sensory loss, and muscle weakness that lead to functional disability. In this article, the authors review common entrapment neuropathies of the upper extremities, including median neuropathy at the wrist (carpal tunnel syndrome), ulnar neuropathy at the elbow, and radial neuropathy. The authors discuss the pathophysiology of nerve compression and typical etiologies, as well as strategies for differentiating between common mimics such as cervical radiculopathy and for selecting between various treatment modalities. Read More

Am J Phys Med Rehabil 2018 Dec 4. Epub 2018 Dec 4.

Neuromusculoskeletal Research Center, Department of Physical Medicine and Rehabilitation, Iran University of Medical Sciences, Tehran, Iran__.

Objective: To investigate the overall estimates of cross-sectional areas (CSA) of the median nerve measured by ultrasonography in accordance with the electrodiagnostic classification of carpal tunnel syndrome (CTS) severity.

Design: MEDLINE (PubMed), EMBASE (Ovid), and Web of Science were searched for studies reporting the median nerve CSA measured by ultrasonography for mild, moderate and severe CTS based on electrodiagnostic study. CSA values measured at the carpal tunnel inlet were included in the analyses. Read More

Physiother Res Int 2019 Jan 29:e1770. Epub 2019 Jan 29.

Department of Basic Sciences, School of Rehabilitation, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Background And Purpose: Cupping therapy has been used widely as a safe and common method to tackle soft tissue lesions in most Asian countries, Central Europe, and parts of the United States. In this study, cupping therapy has been used for the treatment of carpal tunnel syndrome (CTS), which is the most common entrapment neuropathy. The aim of this study was to investigate the effect of cupping therapy on the clinical findings of patients with CTS. Read More

J Biomech 2019 Jan 21. Epub 2019 Jan 21.

Department of Orthopedic Surgery, Mayo Clinic, Rochester, MN, United States. Electronic address:

Inhibited movement patterns of carpal tunnel structures have been found in carpal tunnel syndrome (CTS) patients. Motion analysis on ultrasound images allows us to non-invasively study the (relative) movement of carpal tunnel structures and recently a speckle tracking method using singular value decomposition (SVD) has been proposed to optimize this tracking. This study aims to assess the reliability of longitudinal speckle tracking with SVD in both healthy volunteers and patients with CTS. Read More

Reumatol Clin 2019 Jan 25. Epub 2019 Jan 25.

Departamento de Fisioterapia, Facultad de Ciencias de la Salud, Universidad de Málaga, Málaga, España.

Background And Objectives: Evidence and specific interventions after carpal tunnel release are limited. The main purpose of this study was to elucidate the current practice patterns of professionals from around the world after carpal tunnel release.

Material And Methods: A 15-item English survey was designed and distributed via email and through social networks to professionals from different countries. Read More

PLoS One 2019 28;14(1):e0211369. Epub 2019 Jan 28.

Department of Orthopaedics Surgery, West China Hospital, Sichuan University, Chengdu, People's Republic of China.

Background: Carpal tunnel syndrome is a common neuropathy disorder for which surgical treatment consists of release and reconstruction of the flexor retinaculum. Reports of postoperative clinical outcomes after carpal tunnel release with or without flexor retinaculum reconstruction in several studies are controversial. This meta-analysis aimed to compare the efficacy and safety of carpal tunnel release with or without flexor retinaculum reconstruction. Read More

J Vis Exp 2019 Jan 11(143). Epub 2019 Jan 11.

Department of Orthopedics & Traumatology, The University of Hong Kong;

Axonal degeneration, indicative of surgical decompression, may coexist in carpal tunnel syndrome (CTS) as the disease progresses. However, the current diagnostic and severity gradation system cannot clearly indicate its coexistence, resulting in confusion of appropriate treatment prescription. There are also constraints in conventional methods for differentiation as well. Read More

Neurol India 2019 Jan-Feb;67(Supplement):S55-S61

Central Library, Thapar Institute of Engineering and Technology, Patiala, Punjab, India.

Carpal tunnel syndrome (CTS) is a disease caused by compression of the median nerve passing through the wrist. Patients suffer from severe pain and paresthesis in the median nerve. Compression of the median nerve occurs, with prolonged working on keyboards (computer or laptop or music players) being one of the reasons along with others such as diabetes or rheumatoid arthritis. Read More

Clin Rehabil 2019 Jan 28:269215518822114. Epub 2019 Jan 28.

Department of Kinesiotherapy and Special Methods in Physiotherapy, The Jerzy Kukuczka Academy of Physical Education in Katowice, Katowice, Poland. Email:

J Orthop Case Rep 2018 Jul-Aug;8(4):57-60

Department of Orthopaedics, Aristotle University of Thessaloniki, George Papanikolaou Hospital, Thessaloniki. Greece.

Introduction: Lipofibromatous hamartoma (LFH) is a very rare, benign, slow-growing peripheral nerve tumor.

Case Report: We present a case of LFH of the median nerve, which caused enlargement of the median nerve and the digital branches in a young male, and was treated surgically. Our treatment choice was resection of large portions of the fibrofatty tissue and decompression of the carpal tunnel. Read More

Physiother Theory Pract 2019 Jan 27:1-21. Epub 2019 Jan 27.

a Physiotherapy Department , University of Witwatersrand , Johannesburg , South Africa.

Background: Treatment of chronic pain is challenging and there is often failure of recovery, with the need to look at different approaches in its management. Central mechanisms may contribute to chronicity (i.e. Read More

J Shoulder Elbow Surg 2019 Jan 23. Epub 2019 Jan 23.

Rothman Institute, Thomas Jefferson University, Philadelphia, PA, USA.

Background: Compromised sleep is a known phenomenon with compressive neuropathies such as carpal tunnel syndrome. However, the prevalence of sleep disturbance with cubital tunnel syndrome (CuTS) and the effect on sleep after ulnar nerve decompression are not well understood. We hypothesized that CuTS results in sleep disturbances and that decompression surgery would result in improvement in overall sleep quality. Read More

J Brachial Plex Peripher Nerve Inj 2019 Jan 22;14(1):e1-e8. Epub 2019 Jan 22.

Department of Plastic Surgery, Shifa International Hospital, Islamabad, Pakistan.

 Carpal tunnel syndrome (CTS) is the most frequently encountered compressive neuropathy of the upper limb. The treatment of CTS ranges from conservative management to carpal tunnel release. Many patients with misconception about the potential morbidity and with the hope of successful conservative treatment delay the surgical release of carpal tunnel. Read More

Surgery 2019 Jan 21. Epub 2019 Jan 21.

BG Trauma Center Ludwigshafen, Department for Hand, Plastic and Reconstructive Surgery, Microsurgery, Burn Center, University of Heidelberg, Ludwigshafen, Germany. Electronic address:

Background: Burn-induced compartment syndrome is a severe sequela after circumferential burns of the extremities and is avoidable by immediate release of the underlying pressure under the eschar. Although the current gold standard is operative escharotomy, this procedure carries considerable morbidity. Our study evaluates the safety and effectiveness of immediate enzymatic debridement to prevent the need for operative escharotomy because of burn-induced compartment syndrome in selected patients. Read More

Trop Doct 2019 Jan 24:49475518825219. Epub 2019 Jan 24.

5 Professor, Department of Microbiology, PGIMER and DR. R.M.L. Hospital, New Delhi, India.

Chikungunya (CHIK) has re-emerged as a potential neurotropic virus, with outbreaks recently being reported from many parts of India. The present study was conducted to study the spectrum and outcome of neurological complications in patients of CHIK during the 2016 outbreak in Delhi. A total of 42 cases seropositive for IgM CHIK antibodies by MAC-ELISA and developing neurological complications were enrolled. Read More

Muscle Nerve 2019 Jan 24. Epub 2019 Jan 24.

Department of Neurology, Korea University Ansan hospital, College of Medicine, Ansan-city, South Korea.

Introduction: The aim of this study was to determine whether carpal tunnel syndrome (CTS) patients manifest changes in early-stage motor function and to investigate the utility of a gyrosensor for quantitative evaluation of motor function.

Methods: Angular velocity signal was measured during finger-tapping in 52 patients with mild-to-moderate CTS and 45 controls. Four finger-tapping performance (FTP) parameters - root-mean-squared (RMS) velocity, RMS angle, peak power, and total power - were derived from the signal. Read More

Orthop Nurs 2019 Jan/Feb;38(1):25-30

Mabel Qi He Leow, PhD, Research Fellow, Biomechanics Laboratory, Singapore General Hospital, Singapore. Wendy Teo, BA Hons (Cantab), BM BCh (Oxon), LLM (Harvard), Medical Officer, Department of Hand Surgery, Singapore General Hospital, Singapore. Tzuemn Ling Low, MBBS, MRCS (Edin), Medical Officer, Department of Hand Surgery, Singapore General Hospital, Singapore. Shian Chao Tay, MBBS, FRCS (Edin), FRCS (Glasg), FAMS (Hand Surgery), FAMS (Clinician Scientist), MBiomedSc (Mayo Clinic), Senior Consultant, Department of Hand Surgery, Singapore General Hospital, Singapore; Director, Biomechanics Laboratory, Singapore General Hospital, Singapore; and Adjunct Associate Professor, Duke-NUS Medical School, Singapore.

Background: Hand conditions are common in elderly persons.

Purpose: To assess the prevalence of common hand conditions in elderly persons in a community setting, specifically osteoarthritis of the hand, trigger finger, and carpal tunnel syndrome.

Methods: The elderly persons were recruited from community groups for elderly persons. Read More

Clin Neurophysiol 2019 Mar 31;130(3):321-330. Epub 2018 Dec 31.

Department of Neurology, School of Medicine, University of Patras, Greece.

Objective: To assess the effect of age on the accuracy of high-resolution ultrasound (HRUS) in the diagnosis and grading of carpal tunnel syndrome (CTS).

Methods: Patients with symptoms and signs of CTS (N = 527 wrists) were evaluated using electrodiagnostic studies (EDx) for CTS diagnosis and grading. Median nerve cross-sectional areas at carpal tunnel inlet (CSA) and at forearm level were measured by HRUS and the ratio of these values was calculated (WFR). Read More

Musculoskelet Sci Pract 2019 Jan 12;40:21-33. Epub 2019 Jan 12.

Centre of Precision Rehabilitation for Spinal Pain, School of Sport, Exercise & Rehabilitation Sciences, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK. Electronic address:

Background: Upper limb neurodynamic tests (ULNTs) are used to identify a neuropathic pain component in patients' presenting with arm and/or neck pain. Clinical tests with established diagnostic accuracy are required to not only to inform clinical management but also minimise costs associated with expensive medical investigations.

Objective: To evaluate the role of ULNTs in assessment of peripheral neuropathic pain and to inform their value in clinical practice when assessing patients with arm and/or neck symptoms. Read More

J Exerc Rehabil 2018 Dec 27;14(6):1067-1073. Epub 2018 Dec 27.

Department of Sports Medicine, Imam Hossein Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Carpal tunnel syndrome (CTS) is one of the reasons for labor abandonment due to inability and pain. The aim of this study was to evaluate the effectiveness of gabapentin and exercise training in the treatment of CTS and compare their effects. This single-blind clinical trial was conducted on patients referred to the Imam Hossein hospital's electrodiagnostic (EDX) unit. Read More

Hand (N Y) 2019 Jan 17:1558944718821417. Epub 2019 Jan 17.

1 Grandview Medical Center, Dayton, OH, USA.

Background: Carpal tunnel syndrome (CTS) is one of the most common diagnoses in a hand surgeon's office, with estimated cost exceeding US $2 billion annually in the United States. Due to this prevalence and cost, patients often turn to the Internet for their medical care. It has been estimated that 72% of Internet users have looked online for health information in the last year. Read More

J Ultrasound Med 2019 Jan 17. Epub 2019 Jan 17.

Department of Biostatistics, Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry, India.

Objectives: Carpal tunnel syndrome (CTS) is an entrapment neuropathy resulting from compression of the median nerve at the carpal tunnel (CT). We assessed the role of high-resolution ultrasound (US) in monitoring patients with CTS treated with corticosteroid injection.

Methods: We performed high-resolution US evaluations of the wrists of patients with CTS before and after treatment with local corticosteroid. Read More

J Neurol 2019 Jan 12. Epub 2019 Jan 12.

Department of Neurology, Rigshospitalet, Neuromuscular Research Center, University of Copenhagen, Copenhagen, Denmark.

SPG31 is a hereditary spastic paraplegia (HSP) caused by pathogenic variants in the REEP1 gene. The phenotype (SPG31) has occasionally been described with peripheral nervous system involvement, in additional to the gradually progressing lower limb spasticity that characterizes HSP. The objective of this study was to characterize patients with pathogenic REEP1 variants and neurophysiologically assess the extent of peripheral nerve involvement in this patient group. Read More

J Hand Surg Am 2019 Jan 8. Epub 2019 Jan 8.

Department of Orthopaedics, University of Pittsburgh, Pittsburgh, PA.

Purpose: The purpose of the study was to determine the rate of false positives for nerve conduction studies (NCSs) and ultrasound (US) in a population without signs and symptoms of carpal tunnel syndrome (CTS) using a CTS-6 score of 0 as the reference standard.

Methods: Patients were included in this study if they were referred for NCSs for a reason other than CTS (cubital tunnel syndrome and/or cervical radiculopathy) and they had a CTS-6 score of 0. An US measurement of the cross-sectional area (CSA) of the median nerve at the level of the carpal tunnel inlet was performed by a certified ultrasound technician. Read More

Arch Orthop Trauma Surg 2019 Jan 10. Epub 2019 Jan 10.

Department of Trauma, Hand and Reconstructive Surgery, University Hospital Jena, Am Klinikum 1, 07747, Jena, Germany.

Introduction: Few case reports describe the development of a hematoma under oral anticoagulation as the cause of an atraumatic carpal tunnel syndrome.

Case Report: A 76 years old woman presented an acute atraumatic carpal tunnel syndrome of her left hand under oral anticoagulation with rivaroxaban due to atrial fibrillation. 12 years ago, palmar plate osteosynthesis of a distal radius fracture had been performed on the affected wrist. Read More

J Korean Neurosurg Soc 2019 Jan 31;62(1):90-95. Epub 2018 Dec 31.

Department of Neurosurgery, Gangdong Sacred Heart Hospital, Hallym University Collge of Medicine, Seoul, Korea.

Objective: Anomalous muscles of the wrist are infrequently encountered during carpal tunnel surgery. Anatomic variants of the palmaris longus (PL), flexor digitorum superficialis, lumbricalis and abductor digiti minimi (ADM) have been reported but are usually clinically insignificant. Anomalies of the wrist muscles, encountered during endoscopic carpal tunnel surgery have rarely been described. Read More

Neurol Neurochir Pol 2019 Jan 8. Epub 2019 Jan 8.

Department of General and Hand Surgery, Pomeranian Medical University in Szczecin, ul. Unii Lubelskiej 1, 71-252 Szczecin, Poland.

The objective of this study was to investigate the incidence of familial carpal tunnel syndrome in patients admitted to the authors' institution for carpal tunnel release. Questionnaires completed by 120 patients: 92 women (77%) and 28 men (23%) at a mean age of 56 years at their baseline clinical examination were reviewed. Familial occurrence of the disease was noted in 21 patients (17%): 16 women and five men. Read More

Cureus 2018 Oct 23;10(10):e3487. Epub 2018 Oct 23.

Anatomy, Histology and Embryology, Medical University of Sofia, Sofia, BGR.

The use of medical ultrasound as an imaging modality in the evaluation of the carpal tunnel syndrome has been growing. Technical progress and the introduction of new, high-quality devices and ultra-high frequency transducers with smaller dimensions have led to a better quality of acquired images and the development of new examination methodologies. The sonographic method has a number of advantages: available, non-invasive, cheaper, and allows an easier and faster evaluation and diagnosis of carpal tunnel syndrome, along with the possibility to assess various parameters of the median nerve, including its size, blood flow, and mobility. Read More

J Plast Reconstr Aesthet Surg 2018 Dec 14. Epub 2018 Dec 14.

Department of Neurology, Jagiellonian University Medical College, Kraków, Poland.

Purpose: The aim of this study was to investigate the associations between nerve conduction studies and three commonly used patient-reported outcome measures (Disabilities of the Arm, Shoulder and Hand [DASH], Michigan Hand Outcomes Questionnaire [MHQ], and the Polish version of the Boston Carpal Tunnel Questionnaire [BCTQ]) METHODS: A total of 218 consecutive patients with carpal tunnel syndrome (CTS) completed the BCTQ, MHQ, and DASH questionnaires followed by nerve conduction studies on their first visit to the clinic.

Results: After a 14-day interval, 189 of these patients completed the BCTQ for the second time. The Polish version of the BCTQ was shown to have excellent internal consistency, test-retest reliability, and validity. Read More

Trials 2019 Jan 5;20(1). Epub 2019 Jan 5.

Department of Neurology, Oregon Health &Science University, 3181 SW Sam Jackson Park Road, Mail Code CR120, Portland, OR, 97239, USA.

Background: While acupuncture's mechanism of action is not fully understood, there is consensus that the nervous system plays a key role in processing its effects. This research is based on the structural theory of acupuncture, which aims to correlate the location of acupuncture points to peripheral nerves, spinal segments, and spinal plexuses. This mechanistic study explores the close anatomical association between the Pericardium meridian/median nerve and the Heart meridian/ulnar nerve in an attempt to produce electrophysiologic data measuring acupuncture's direct, nerve-specific effect on the underlying nerves. Read More

Medicine (Baltimore) 2019 Jan;98(1):e13795

Department of Nursing, Chung Hwa University of Medical Technology, Tainan, Taiwan.

De Quervain's disease, carpal tunnel syndrome (CTS), and trigger finger (digit) are three common pathological conditions of the hand. They are considered overuse syndromes and occur predominantly in females. The prevalence rate and cause-specific risks of these three tendinopathies have not yet been clarified. Read More

Syst Rev 2019 Jan 3;8(1). Epub 2019 Jan 3.

Chan Division of Occupational Science and Occupational Therapy, University of Southern California, 1640 Marengo St, Suite 505, Los Angeles, CA, 90089-9256, USA.

Background: Median nerve cross-sectional area (CSA) is the primary sonographic parameter for assessing and diagnosing median nerve pathology, such as carpal tunnel syndrome. However, variability in the sensitivity of diagnostic thresholds exists, which may be due to a lack of standardized normative reference values. Current estimates of normal median nerve CSA stem largely from small studies using a local pool of healthy controls. Read More

Ideggyogy Sz 2018 Nov;71(11-12):417-422

Clinic of Neurology, Sakarya University, Sakarya Training and Research Hospital, Sakarya, Turkey.

Background And Purpose: The aim of this study was to evaluate the relationship between electrophysiological stage, symptom severity, functional status and anxiety levels in patients with idiopathic carpal tunnel syndrome (CTS).

Methods: This study included 130 patients in the 25-79 age group who were classified as clinically and electrophysiologically idiopathic carpal tunnel syndrome in our electromyography (EMG) laboratory. Visual Analog Scale (VAS) was used to assess pain during rest and activity. Read More

Neurodiagn J 2019 Jan 2:1-11. Epub 2019 Jan 2.

b Department of Radiology Assiut University , Assiut , Egypt.

Background And Purpose: The Neuromuscular ultrasound and Nerve conduction studies/Electromyography (NCS/EMG) are valuable diagnostic tools that examine and diagnose several nerve problems. The purpose of this case report is to describe a diagnostic electrophysiologic evaluation that differentiates between carpal tunnel syndrome (CTS) and radiculopathy in very mild or early stage cases.

Case Description: The patient was a 30-year-old woman who sustained a tingling sensation in the second and third digits of her left hand, radiating pain in her left upper extremity and occasional neck pain. Read More

J Clin Ultrasound 2018 Dec 29. Epub 2018 Dec 29.

Department of Orthopaedics & Traumatology, Prince of Wales Hospital, Shatin, NT, Hong Kong.

Background: This study compares median nerve cross-sectional area (CSA) measurements at the wrist obtained with ultrasound (US) and magnetic resonance imaging (MRI) using cadaveric measurements as the gold standard.

Methods: Median nerve CSA was measured using US and MRI in 9 cadaveric wrists obtained from 5 subjects at 5 locations: distal forearm, proximal to tunnel inlet, at tunnel inlet, at tunnel outlet, and distal to tunnel outlet and then on identical cadaveric transverse sections obtained with a bandsaw. All US, MRI, and cadaveric measurements were repeated to determine reliability. Read More

J Cardiol Cases 2018 Dec 22;18(6):185-188. Epub 2018 Oct 22.

Kowloon West Cluster Laboratory Genetic Service, Chemical Pathology Laboratory, Department of Pathology, Princess Margaret Hospital, Hong Kong, China.

Hereditary transthyretin-related amyloidosis (ATTR, MIM #105210), also previously known as familial amyloidotic polyneuropathy, is one of the most life-threatening types of amyloidosis. ATTR is inherited in autosomal dominant mode with variable penetrance. If untreated, it is a relentless and lethal disease. Read More

J Manipulative Physiol Ther 2018 Oct 26;41(8):641-649. Epub 2018 Dec 26.

Department of Kinesiotherapy and Special Physiotherapy Methods, The Jerzy Kukuczka Academy of Physical Education, Katowice, Katowice, Poland. Electronic address:

Objective: The purpose of this study was to assess the influence of manual therapy, including neurodynamic techniques, compared with no treatment on overall health status (OHS) in patients with mild to moderate carpal tunnel syndrome (CTS).

Methods: The study included 189 patients with CTS who were randomly assigned to the manual therapy (MT) group (including the use of neurodynamic techniques) or to the control group (CG; without therapy). The CTS diagnosis was made on the basis of nerve conduction studies and clinical examinations. Read More

Medicine (Baltimore) 2018 Dec;97(52):e13943

Department of Rehabilitation Medicine.

Rationale: Carpal tunnel syndrome (CTS) is the most common peripheral nerve neuropathy resulting from compression of the median nerve as it traverses the carpal tunnel. The pathophysiology of this condition is multifactorial, and majority of cases of CTS are idiopathic. We report cases of CTS caused by synovial osteochondromatosis (SOC), which has rarely been reported. Read More

Plast Reconstr Surg 2019 Jan;143(1):169-175

Phoenix, Ariz. From the Departments of Orthopedic Surgery and Laboratory Medicine and Pathology, Mayo Clinic Hospital.

Background: The authors' purpose was to evaluate the histopathology of flexor tenosynovium in true, idiopathic recurrent carpal tunnel syndrome for the presence of abnormal inflammatory or pathologic findings that might explain causation or that differ from those previously described for primary, idiopathic carpal tunnel syndrome.

Methods: Thirty-five patients (19 women and 16 men; mean age, 72 years) underwent open revision carpal tunnel release a mean 13 years (range, 0.5 to 30 years) after primary carpal tunnel release. Read More