2,207 results match your criteria Caroli Disease Imaging
Am J Surg Pathol 2018 Dec 4. Epub 2018 Dec 4.
Department of Human Pathology, Kanazawa University Graduate School of Medicine, Kanazawa.
Cholangiolocellular carcinoma (CLC) is a unique subtype of primary liver carcinoma, which sometimes coexists with hepatocellular carcinoma (HCC), cholangiocarcinoma and combined hepatocellular-cholangiocarcinoma (cHCC-CCA). "Ductal plate malformation" (DPM)-pattern of primary liver carcinoma, which resembles biliary lesions in Caroli disease and von Meyenburg complex, is sometimes associated with CLC. We examined genetic alterations of hTERT promoter (hTERT), IDH1 or 2 (IDH1/2), KRAS, ARID1A, PBRM1, ARID2, BAP1, p53 and their association with histologic features such as proportion of CLC and DPM-pattern in 77 patients with primary liver carcinoma diagnosed as cHCC-CCA or CLC. Read More
BMC Nephrol 2018 Dec 4;19(1):347. Epub 2018 Dec 4.
Department of Medical Sciences, Scientific Institute "Casa Sollievo della Sofferenza", IRCCS Casa Sollievo della Sofferenza, v.le Cappuccini, 71013, San Giovanni Rotondo, FG, Italy.
Background: Albuminuria has been classically considered a marker of kidney damage progression in diabetic patients and it is routinely assessed to monitor kidney function. However, the role of a mild GFR reduction on the development of stage ≥3 CKD has been less explored in type 1 diabetes mellitus (T1DM) patients. Aim of the present study was to evaluate the prognostic role of kidney disease measures, namely albuminuria and reduced GFR, on the development of stage ≥3 CKD in a large cohort of patients affected by T1DM. Read More
Radiol Case Rep 2019 Feb 26;14(2):265-268. Epub 2018 Nov 26.
Department of Radiology, The Children's Hospital of Philadelphia, 34th Street and Civic Center Boulevard, Philadelphia, PA 10104, USA.
Caroli syndrome, which is characterized by saccular and fusiform dilatation of the biliary ducts, is usually observed in association with autosomal recessive polycystic kidney disease (ARPKD). Although the diagnosis of ARPKD is generally easy to make in postnatal ultrasound, the diagnosis of Caroli syndrome may be challenging in prenatal ultrasound. Herein, we present a case of a 29-week fetus with ARPKD associated with Caroli syndrome in whom fetal magnetic resonance imaging was essential to identify the "central dot sign" within the dilated biliary ducts to confirm the prenatal diagnosis of Caroli syndrome and to increase our level of confidence in this diagnosis. Read More
Nano Lett 2018 Nov 26. Epub 2018 Nov 26.
We have performed device-based tunnelling spectroscopy of NbSe in the vortex state with magnetic field applied both parallel and perpendicular to the a-b plane. Our devices consist of layered semiconductors placed on top of exfoliated NbSe using the van der Waals transfer technique. At zero field, the spectrum exhibits a hard gap, and the quasiparticle peak is split into low and high energy features. Read More
Radiat Oncol 2018 Oct 25;13(1):211. Epub 2018 Oct 25.
Radiotherapy, University Hospital "Maggiore della Carità", Novara, Italy.
Background: [18F] fluorodeoxyglucose positron emission tomography/computed tomography ([18F] FDG-PET/CT) may be used for tumor staging and prognosis in several tumors but its role in rectal cancer is still debated. The aim of the present study was to assess the correlation of baseline [18F] FDG-PET parameters with tumor staging, tumor response (tumor regression grade (TRG)), and outcome in a series of patients affected by locally advanced rectal cancer (LARC) treated with neoadjuvant chemoradiotherapy (CRT).
Methods: One hundred patients treated with neoadjuvant CRT and radical surgery were enrolled in the present study. Read More
Clin J Gastroenterol 2018 Oct 20. Epub 2018 Oct 20.
Human Stem Cells Institute, Moscow, Russia.
Herein we present a clinical case of the Caroli syndrome caused by the compound heterozygous mutation in the PKHD1 gene. Histopathological assessment of liver detected biliary cirrhosis, numerous dilated bile ducts of various sizes, hyperplastic cholangiocytes containing a large amount of acid mucopolysaccharides, decreased ß-tubulin expression and increased proliferation of cholangiocytes. A significant proportion of hepatic tissue was composed of giant cysts lined with a single layer of cholangiocytes, containing pus and bile in its lumen and surrounded by granulation tissue. Read More
Genome Res 2018 11 19;28(11):1720-1732. Epub 2018 Oct 19.
BioTuring Incorporated, San Diego, California 92121, USA.
Despite the rapid development of sequencing technologies, the assembly of mammalian-scale genomes into complete chromosomes remains one of the most challenging problems in bioinformatics. To help address this difficulty, we developed Ragout 2, a reference-assisted assembly tool that works for large and complex genomes. By taking one or more target assemblies (generated from an NGS assembler) and one or multiple related reference genomes, Ragout 2 infers the evolutionary relationships between the genomes and builds the final assemblies using a genome rearrangement approach. Read More
World Neurosurg 2018 Oct 3. Epub 2018 Oct 3.
Laboratory of Experimental Neurosurgery and Cell Therapy, Neurosurgery Unit, University of Milan, Milan, Italy.
Background: Coagulation is an important aspect of the vascular microenvironment in which brain tumors evolve. Patients with tumor often show aberrant coagulation and fibrinolysis activation. In particular, glioblastoma (GBM), the most aggressive primary brain tumor, is associated with a state of hypercoagulability, and venous thromboembolism is a common complication of this cancer and its treatment. Read More
Biosci Trends 2018 Sep 26;12(4):426-431. Epub 2018 Aug 26.
Department of Visceral Surgery, University Hospital of Lausanne.
Congenital intrahepatic bile duct dilatation (Caroli's disease) is a rare biliary disease. Although multiple reports exist describing its surgical treatment, relatively few have provided long-term follow-up. Prospective data about 25 cases of monolobular Caroli's disease, with liver resection between 1974 and 2016, were retrospectively analyzed. Read More
World Neurosurg 2018 Dec 23;120:e380-e391. Epub 2018 Aug 23.
Laboratory of Experimental Neurosurgery and Cell Therapy, Neurosurgery Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy. Electronic address:
Background: Glioblastoma (GBM) is the most common and fatal human brain tumor, with the worst prognosis. The aberrant microenvironment, enhanced by the activation of proangiogenic mediators such as hypoxia-inducible factor-1α (HIF-1α), vascular endothelial growth factor (VEGF), and their downstream effectors, sustain GBM malignancy. Proangiogenic signaling represents an attractive chemotherapeutic target. Read More
Nephrol Dial Transplant 2018 Sep;33(suppl_2):ii4-ii14
Leeds Imaging Biomarkers Group, Department of Biomedical Imaging Sciences, University of Leeds, Leeds, UK.
Functional renal magnetic resonance imaging (MRI) has seen a number of recent advances, and techniques are now available that can generate quantitative imaging biomarkers with the potential to improve the management of kidney disease. Such biomarkers are sensitive to changes in renal blood flow, tissue perfusion, oxygenation and microstructure (including inflammation and fibrosis), processes that are important in a range of renal diseases including chronic kidney disease. However, several challenges remain to move these techniques towards clinical adoption, from technical validation through biological and clinical validation, to demonstration of cost-effectiveness and regulatory qualification. Read More
Nephrol Dial Transplant 2018 Sep;33(suppl_2):ii41-ii50
Clinic of Radiology and Nuclear Medicine, St. Olavs University Hospital, Trondheim, Norway.
This systematic review, initiated by the European Cooperation in Science and Technology Action Magnetic Resonance Imaging Biomarkers for Chronic Kidney Disease (PARENCHIMA), focuses on potential clinical applications of magnetic resonance imaging in renal non-tumour disease using magnetic resonance relaxometry (MRR), specifically, the measurement of the independent quantitative magnetic resonance relaxation times T1 and T2 at 1.5 and 3Tesla (T), respectively. Healthy subjects show a distinguishable cortico-medullary differentiation (CMD) in T1 and a slight CMD in T2. Read More
Nephrol Dial Transplant 2018 Sep;33(suppl_2):ii1-ii3
Centre for Kidney Research and Innovation, University of Nottingham, Nottingham, UK.
Nephrol Dial Transplant 2018 Sep;33(suppl_2):ii29-ii40
Division of Radiology, Geneva University Hospitals, University of Geneva, Geneva, Switzerland.
Diffusion-weighted magnetic resonance imaging (DWI) is a non-invasive method sensitive to local water motion in the tissue. As a tool to probe the microstructure, including the presence and potentially the degree of renal fibrosis, DWI has the potential to become an effective imaging biomarker. The aim of this review is to discuss the current status of renal DWI in diffuse renal diseases. Read More
Nephrol Dial Transplant 2018 Sep;33(suppl_2):ii22-ii28
Department of Radiology, NorthShore University HealthSystem, Evanston, IL, USA.
Tissue hypoxia plays a key role in the development and progression of many kidney diseases. Blood oxygenation level-dependent magnetic resonance imaging (BOLD-MRI) is the most promising imaging technique to monitor renal tissue oxygenation in humans. BOLD-MRI measures renal tissue deoxyhaemoglobin levels voxel by voxel. Read More
J Morphol 2018 Sep 17;279(9):1234-1255. Epub 2018 Aug 17.
Institut des Sciences de l'Evolution de Montpellier, Université Montpellier, CNRS, IRD, EPHE, Cc 064, place Eugène Bataillon, 34095 Montpellier Cedex 5, France.
Murine rodents display a unique cranial morphology and masticatory musculature. Yet detailed myological descriptions are scarce, especially considering the great diversity of the subfamily and the use of the house mouse and brown rat as model organisms. The masticatory musculature in these two species has been thoroughly described, which allows comparisons with other wild species. Read More
Ital J Pediatr 2018 Jul 31;44(1):88. Epub 2018 Jul 31.
Department of Social Sciences, University of Naples Federico II, Naples, Italy.
The Italian Consensus Position Statement on Diagnosis, Treatment and Prevention of Obesity in Children and Adolescents integrates and updates the previous guidelines to deliver an evidence based approach to the disease. The following areas were reviewed: (1) obesity definition and causes of secondary obesity; (2) physical and psychosocial comorbidities; (3) treatment and care settings; (4) prevention.The main novelties deriving from the Italian experience lie in the definition, screening of the cardiometabolic and hepatic risk factors and the endorsement of a staged approach to treatment. Read More
Am J Pathol 2018 Oct 20;188(10):2251-2263. Epub 2018 Jul 20.
Department of Human Pathology, Kanazawa University Graduate School of Medicine, Kanazawa, Japan.
Caroli disease represents a hepatic manifestation of autosomal recessive polycystic kidney disease, and belongs to a class of cholangiociliopathies. The role of Hedgehog signaling, a major pathway regulated by primary cilia, in biliary cystogenesis in Caroli disease remains unknown. Using the polycystic kidney (PCK) rat as an animal model of Caroli disease, this study investigated the involvement of Hedgehog signaling in its pathogenesis. Read More
J Gastrointest Cancer 2018 Jul 13. Epub 2018 Jul 13.
Department of General and Visceral Surgery, Sozialstiftung Bamberg, Bamberg, Germany.
MAbs 2018 Oct 6;10(7):1084-1097. Epub 2018 Aug 6.
a Molecular Therapies Unit, Department of Experimental Oncology and Molecular Medicine , Fondazione IRCCS Istituto Nazionale dei Tumori , Milan , Italy.
Recombinant human tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) or TRAIL-receptor agonistic monoclonal antibodies promote apoptosis in most cancer cells, and the differential expression of TRAIL-R2 between tumor and normal tissues allows its exploitation as a tumor-associated antigen. The use of these antibodies as anticancer agents has been extensively studied, but the results of clinical trials were disappointing. The observed lack of anticancer activity could be attributed to intrinsic or acquired resistance of tumor cells to this type of treatment. Read More
J Visc Surg 2018 Jun 18. Epub 2018 Jun 18.
Department of General, Visceral and Vascular Surgery, Jena University Hospital, Am Klinikum 1, 07747 Jena, Germany.
Introduction: Caroli disease (CD) is a congenital dilatation of the intrahepatic bile ducts. In combination with liver fibrosis or cirrhosis, it is called Caroli syndrome (CS). Infectious complications and intrahepatic cholangiocarcinoma are secondary problems. Read More
Eur J Nucl Med Mol Imaging 2018 Jun 19. Epub 2018 Jun 19.
Nuclear Medicine Unit, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, Via P. Maroncelli 40, 47014, Meldola, Italy.
Purpose: We studied the usefulness of Ga-prostate-specific membrane antigen (PSMA) PET/CT for detecting relapse in a prospective series of patients with biochemical recurrence (BCR) of prostate cancer (PCa) after radical treatment.
Methods: Patients with BCR of PCa after radical surgery and/or radiotherapy with or without androgen-deprivation therapy were included in the study. Ga-PSMA PET/CT scans performed from the top of the head to the mid-thigh 60 min after intravenous injection of 150 ± 50 MBq of Ga-PSMA were interpreted by two nuclear medicine physicians. Read More
J Pediatr Gastroenterol Nutr 2018 Nov;67(5):561-563
WHO Regional Office for Europe, Copenhagen, Denmark.
Sci Rep 2018 Jun 8;8(1):8748. Epub 2018 Jun 8.
Laboratory of Experimental Neurosurgery and Cell Therapy, Neurosurgery Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, University of Milan, Milan, Italy.
Gliomas are the most common brain tumors, with diverse biological behaviour. Glioblastoma (GBM), the most aggressive and with the worst prognosis, is characterized by an intense and aberrant angiogenesis, which distinguishes it from low-grade gliomas (LGGs) and benign expansive lesions, as meningiomas (MNGs). With increasing evidence for the importance of vascularization in tumor biology, we focused on the isolation and characterization of endothelial cells (ECs) from primary GBMs, LGGs and MNGs. Read More
Nucleic Acids Res 2018 Jul;46(W1):W148-W156
Dept. of Life Sciences, University of Modena and Reggio Emilia, Via G. Campi, 287, 41125 Modena, Italy.
Several major screenings of genetic profiling and drug testing in cancer cell lines proved that the integration of genomic portraits and compound activities is effective in discovering new genetic markers of drug sensitivity and clinically relevant anticancer compounds. Despite most genetic and drug response data are publicly available, the availability of user-friendly tools for their integrative analysis remains limited, thus hampering an effective exploitation of this information. Here, we present GDA, a web-based tool for Genomics and Drugs integrated Analysis that combines drug response data for >50 800 compounds with mutations and gene expression profiles across 73 cancer cell lines. Read More
J Dairy Sci 2018 Jun;101(6):4705
Department of Molecular and Translational Medicine, University of Brescia, Brescia 25123, Italy.
J Biomed Opt 2018 May;23(5):1-8
Duke University Medical Center, Department of Surgery, Durham, North Carolina, United States.
Diffuse reflectance spectroscopy (DRS) represents a quantitative, noninvasive, nondestructive means of assessing vascular oxygenation, vascularity, and structural properties. However, it is known that such measurements can be influenced by the effects of pressure, which is a major concern for reproducible and operator-independent assessment of tissues. Second, regular calibration is a necessary component of quantitative DRS to account for factors such as lamp decay and fiber bending. Read More
Ig Sanita Pubbl 2018 Jan-Feb;74(1):25-34
Ufficio Qualità Azienda USL della Romagna, Italia.
In order to find the optimal value of the hot water temperature to be reached so that there is no Legionella spp. at the dispensing points, 920 samples of water at temperature between 54 and 60 Celsius degree were analyzed at the Lugo and Faenza hospitals (Ravenna). Thought the analysis of the linear trendline results indicate that the temperature required is close to 60 degrees but as it's difficult to maintain in old plants, a careful patient's risk assessment needs to be carried out and therefore install antibacterial membrane filters at the dispensers. Read More
Rev Med Interne 2018 Apr 24. Epub 2018 Apr 24.
Service d'imagerie médicale, hôpital Militaire Mohamed V, 10120 Rabat, Maroc.
Beijing Da Xue Xue Bao Yi Xue Ban 2018 Apr;50(2):335-339
Department of Pediatrics, Peking University First Hospital, Beijing 100034, China.
This case report is about one genetically specified diagnosed infant case of Caroli syndrome with autosomal recessive polycystic kidney disease (ARPKD) in China. The patient in this case report was an eight-month infant boy with an atypical onset and the main clinical manifestation was non-symptomatic enlargement of the liver and kidneys. The imaging study demonstrated a diffused cystic dilatation of intrahepatic bile ducts as well as polycystic changes in bilateral kidneys. Read More
J Cardiovasc Echogr 2018 Jan-Mar;28(1):51-53
Cardiology and Arrhythmology Clinic, University Hospital, Marche Polytechnic University, Ancona, Italy.
Atrial masses are rare and more often localized in the right atrium. They are usually detected incidentally, and the leading causes are tumors, thrombi, or infective vegetations. However, normal structures and artifacts ("pseudomasses") should also be considered in differential diagnosis, especially after cardiac and/or aortic surgery. Read More
Gastroenterology 2018 Sep 6;155(3):621-622. Epub 2018 Apr 6.
Liver Disease Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland.
Int J Med Inform 2018 May 21;113:9-16. Epub 2018 Feb 21.
University of Michigan Medical School, Department of Family Medicine, Ann Arbor, MI, USA. Electronic address:
Background: Psychosocial information informs clinical decisions by providing crucial context for patients' barriers to recommended self-care; this is especially important in outpatient diabetes care because outcomes are largely dependent upon self-care behavior. Little is known about provider perceptions of use of psychosocial information. Further, while EHRs have dramatically changed how providers interact with patient health information, the EHRs' role in collection and retrieval of psychosocial information is not understood. Read More
Clin Transl Radiat Oncol 2017 Jun 17;4:8-14. Epub 2017 May 17.
Department of Radiotherapy, Fondazione "Policlinico Gemelli", Università Cattolica S. Cuore, Roma, Italy.
Background: To retrospectively evaluate the difference in terms of pathologic complete response (pCR) according to time elapsed between chemoradiation (CRT) and total mesorectal excision (TME) on a large unselected real-life dataset of locally advanced rectal cancer (LARC) patients.
Methods: A multicentre retrospective cohort study of LARC patients from 21 Italian Radiotherapy Institutions was performed. Patients were stratified into 3 different time intervals from CRT. Read More
Genome Res 2018 04 21;28(4):448-459. Epub 2018 Mar 21.
European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SD, United Kingdom.
Understanding the mechanisms driving lineage-specific evolution in both primates and rodents has been hindered by the lack of sister clades with a similar phylogenetic structure having high-quality genome assemblies. Here, we have created chromosome-level assemblies of the and genomes. Together with the and genomes, this set of rodent genomes is similar in divergence times to the Hominidae (human-chimpanzee-gorilla-orangutan). Read More
Ann Surg Treat Res 2018 Mar 28;94(3):162-165. Epub 2018 Feb 28.
Department of General Surgery, Zhongda Hospital, Southeast University, Nanjing, China.
Caroli disease is a rare congenital disorder characterized by nonobstructive dilatation of intrahepatic ducts. In cases with symptomatic intrahepatic manifestations, treatment should correspond to the type with hepatic resection for localized disease and transplantation for diffuse forms. If possible, complete resection of the cysts can cure the symptoms and avoid the risk of malignancy. Read More
Nat Commun 2018 03 6;9(1):970. Epub 2018 Mar 6.
Center for Superconducting Physics and Materials, National Laboratory of Solid State Microstructures and Department of Physics, Collaborative Innovation Center for Advanced Microstructures, Nanjing University, 210093, Nanjing, China.
Caroli-de Gennes-Matricon (CdGM) states were predicted in 1964 as low-energy excitations within vortex cores of type-II superconductors. In the quantum limit, the energy levels of these states were predicted to be discrete with the basic levels at ±μΔ/E (μ = 1/2, 3/2, 5/2, …) with Δ the superconducting energy gap and E the Fermi energy. However, due to the small ratio of Δ/E in most type-II superconductors, it is very difficult to observe the discrete CdGM states, but rather a symmetric peak which appears at zero bias at the vortex center. Read More
J Neurooncol 2018 Jun 2;138(2):401-406. Epub 2018 Mar 2.
Neurosurgery, Fondazione IRCCS Ca' Granda - Ospedale Maggiore Policlinico, Via F. Sforza, 35, 20122, Milan, Italy.
The surgical resection of meningiomas can be complicated by venous thromboembolism (VTE) in the post-operative period, but the exact incidence of this event is not known. Aim of this study was to assess the occurrence of VTE in patients operated for meningioma who underwent a post-operative clinical and objective screening for VTE. Patients undergoing meningioma resection between 2000 and 2010 who accepted to be investigated for VTE in the post-operative period were included in the study. Read More
AJR Am J Roentgenol 2018 Apr 15;210(4):748-760. Epub 2018 Feb 15.
1 Department of Radiology, University of Miami Miller School of Medicine, Jackson Memorial Hospital, 1611 NW 12th Ave, WW 279, Miami, FL 33136-1015.
Objective: The purpose of this article is to review the relevant pathophysiologic features, appearances, and surgical implications of choledochal malformations.
Conclusion: Choledochal malformations, colloquially called choledochal cysts, initially described in 1723, have been recategorized multiple times, the most widely accepted being the Todani classification based on morphologic features and location. Although readily applied to imaging findings, this classification system does not correlate well with clinical and surgical management. Read More
J Chem Phys 2018 Feb;148(5):054901
NAVIER, UMR 8205, École des Ponts, IFSTTAR, CNRS, UPE, 2 allée Képler, F-77420 Marne-la-Vallée, France.
The stress response of permanently crosslinked gelatin gels was recently observed to display glass-like features, namely, a stretched-exponential behavior terminated by an exponential decay, the characteristic time scales of which increase dramatically with decreasing temperature. This phenomenon is studied here using a model of flexible polymer gel network where relaxation proceeds via elementary monomer exchanges between helix and coil segments. The relaxation dynamics of a full network simulation is found to be nearly identical to that of a model of independent strands, which shows that for flexible polymer gels in the range of elastic moduli of interest, both strand contour length disorder and elastic couplings are irrelevant. Read More
J Neurooncol 2018 May 12;137(3):611-619. Epub 2018 Jan 12.
Division of Neurosurgery, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Via F. Sforza, 35, 20122, Milan, Italy.
Surgical treatment of elderly patients with meningioma is has proved to be safe, especially when patients are selected using dedicated surgical scores. These scores take into account tumor size, edema, location and patient's co-morbidities. Neuropsychological functioning (NPF) of this kind of patients has been poorly studied in literature and it is not taken into account by these scores. Read More
Phys Rev Lett 2017 Dec 4;119(23):237001. Epub 2017 Dec 4.
Department of Quantum Matter Physics, University of Geneva, 24 quai Ernest-Ansermet, 1211 Geneva, Switzerland.
The copper oxides present the highest superconducting temperature and properties at odds with other compounds, suggestive of a fundamentally different superconductivity. In particular, the Abrikosov vortices fail to exhibit localized states expected and observed in all clean superconductors. We have explored the possibility that the elusive vortex-core signatures are actually present but weak. Read More
Acta Paediatr 2018 Apr 22;107(4):568-576. Epub 2017 Nov 22.
School of Medicine, European University Cyprus, Engomi, Cyprus.
This study reviewed the link between social media and the growing epidemic of childhood obesity in Europe. A task force from the European Academy of Paediatrics and the European Childhood Obesity Group searched published literature and developed a consensus statement. It found that there was evidence of a strong link between obesity levels across European countries and childhood media exposure and that parents and society needed a better understanding of the influence of social media on dietary habits. Read More
Cureus 2017 Sep 20;9(9):e1701. Epub 2017 Sep 20.
Department of Biomedical Sciences and Medicine, University of Algarve.
Caroli's disease is a very rare congenital malformation, currently included in cystic diseases of the biliary tract, and is characterized by ectasia and dilatation of the intrahepatic bile ducts. Two clinical entities can be distinguished, Caroli's disease in which congenital hepatic impairment is limited to cystic dilatation and Caroli's syndrome in which congenital hepatic fibrosis coexists. We present two cases of atypical presentations of Caroli's disease. Read More
Hepatology 2018 05 25;67(5):1903-1919. Epub 2018 Mar 25.
Section of Digestive Diseases, Liver Center, Yale University, New Haven, CT.
Congenital hepatic fibrosis (CHF), a genetic disease caused by mutations in the polycystic kidney and hepatic disease 1 (PKHD1) gene, encoding for the protein fibrocystin/polyductin complex, is characterized by biliary dysgenesis, progressive portal fibrosis, and a protein kinase A-mediated activating phosphorylation of β-catenin at Ser675. Biliary structures of Pkhd1 mice, a mouse model of CHF, secrete chemokine (C-X-C motif) ligand 10 (CXCL10), a chemokine able to recruit macrophages. The aim of this study was to clarify whether CXCL10 plays a pathogenetic role in disease progression in CHF/Caroli disease and to understand the mechanisms leading to increased CXCL10 secretion. Read More
Sci Rep 2017 Nov 14;7(1):15541. Epub 2017 Nov 14.
Department of Medical Oncology, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, via Maroncelli 40, 47014, Meldola, Italy.
The association between choline uptake and androgen receptor (AR) expression is suggested by the upregulation of choline kinase-alpha in prostate cancer. Recently, detection of AR aberration in cell-free DNA as well as early 18F-fluorocholine positron emission tomography/computed tomography (FCH-PET/CT) were associated with outcome in metastatic castration-resistant prostate cancer (mCRPC) patients treated with abiraterone and enzalutamide. We aimed to make a direct comparison between circulating AR copy number (CN) and choline uptake at FCH-PET/CT. Read More
Gen Hosp Psychiatry 2017 11;49:63-66
Department of Veteran Affairs, Center for Clinical Management Research, Ann Arbor, MI, USA; Department of Psychiatry, University of Michigan, 2800 Plymouth Rd NCRC B16-242E, Ann Arbor, MI, USA. Electronic address:
Objective: This study assessed the beliefs, barriers and preferences for physical activity (PA) among users of outpatient mental health (MH) services. Outpatient discussions with MH providers were also evaluated.
Method: Between September-December 2014, patient advisors approached adult and family members in an academic MH clinic's waiting room on high volume patient visit days during peak clinic hours; 83% participated in the survey. Read More
Eur J Nucl Med Mol Imaging 2018 03 6;45(3):348-354. Epub 2017 Nov 6.
Nuclear Medicine Unit, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, Meldola, Italy.
Purpose: The role of 18F-choline positron emission tomography/computed tomography (FCH-PET/CT) in patients with metastatic castration-resistant prostate cancer (mCRPC) has been firmly established in recent years. We analyzed the prognostic value of functional parameters such as mean standardized uptake volume (SUVmean), maximum standardized uptake volume (SUVmax), metabolic total volume (MTV; the volume of interest consisting of all spatially connected voxels within a fixed threshold of 40% of the SUVmax), and total lesion activity (TLA: the product of MTV and mean standardized uptake value) estimated with FCH-PET/CT in mCRPC patients in progression after docetaxel and treated with new antiandrogen receptor therapies, abiraterone or enzalutamide.
Methods: We retrospectively studied 94 mCRPC patients, mean age 74 years (range 42-90), previously treated with docetaxel who were treated with either abiraterone (n = 52) or enzalutamide (n = 42). Read More