778 results match your criteria Cardiovascular toxicology[Journal]


Involvement of ROS/NLRP3 Inflammasome Signaling Pathway in Doxorubicin-Induced Cardiotoxicity.

Cardiovasc Toxicol 2020 Jun 30. Epub 2020 Jun 30.

Department of Pharmacy, The Second Xiangya Hospital, Central South University, Changsha, 410011, Hunan, China.

Doxorubicin (Dox) is widely used in cancer therapy, but the clinical application is limited by its cardiotoxicity. The underlying mechanism of Dox-induced cardiotoxicity remains unclear. Present study aimed to evaluate the role of NLRP3 inflammasome in Dox-induced cardiotoxicity. Read More

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http://dx.doi.org/10.1007/s12012-020-09576-4DOI Listing

Calcium Oxalate Monohydrate is Associated with Endothelial Cell Toxicity But Not with Reactive Oxygen Species Accumulation.

Cardiovasc Toxicol 2020 Jun 25. Epub 2020 Jun 25.

Department of Pharmacology, Toxicology & Neuroscience, Louisiana State University Health Sciences Center, Shreveport, LA, 71130-3932, USA.

One characteristic of ethylene glycol overdose is a cardiopulmonary syndrome including hypertension and pulmonary edema with pathology indicating damage to the endothelium of heart, lung and brain vessels. The mechanism of the cardiopulmonary toxicity is unknown, but has been linked with accumulation of the metabolite calcium oxalate monohydrate (COM) in the endothelium. These studies have evaluated the hypothesis that COM or the oxalate ion produces endothelial damage in vitro and that damage is linked with induction of reactive oxygen species (ROS). Read More

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http://dx.doi.org/10.1007/s12012-020-09584-4DOI Listing

Modulation of Paraoxonase-1 and Apoptotic Gene Expression Involves in the Cardioprotective Role of Flaxseed Following Gestational Exposure to Diesel Exhaust Particles and/or Fenitrothion Insecticide.

Cardiovasc Toxicol 2020 Jun 22. Epub 2020 Jun 22.

Department of Zoology, College of Science, King Saud University, P.O. Box 2455, Riyadh, 11451, Saudi Arabia.

The developmental exposure to a single chemical may elicit apoptosis in the different fetal organs, while the combined effects are restricted. We have examined the protective role of flaxseed (FS) against diesel exhaust particles (DEPs)- and/or fenitrothion (FNT)-induced fetal cardiac oxidative stress and apoptosis. A total of 48 timed pregnant rats were divided into eight groups (n = 6). Read More

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http://dx.doi.org/10.1007/s12012-020-09585-3DOI Listing

Delayed-type Hypersensitivity to Metals in Newly Diagnosed Patients with Nonischemic Dilated Cardiomyopathy.

Cardiovasc Toxicol 2020 Jun 15. Epub 2020 Jun 15.

Department of Internal Medicine and Cardiology, University Hospital Brno and Faculty of Medicine, Masaryk University, Brno, Czech Republic.

The causes of nonischemic dilated cardiomyopathy are classified as genetic or nongenetic, but environmental factors such as metal pollutants may interact with genetic susceptibility. The presence of metal particles has been detected in the myocardium, including in those patients with dilated cardiomyopathy. It is also known that hypersensitivity reactions can induce inflammation in tissue. Read More

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http://dx.doi.org/10.1007/s12012-020-09582-6DOI Listing
June 2020
2.060 Impact Factor

Speckle-Tracking Echocardiography for Cardioncological Evaluation in Bevacizumab-Treated Colorectal Cancer Patients.

Cardiovasc Toxicol 2020 Jun 9. Epub 2020 Jun 9.

Cardiology and Cardiovascular Pathophysiology, Azienda Ospedaliero-Universitaria "S. Maria Della Misericordia", Perugia, Italy.

Angiogenesis inhibitor Bevacizumab (BVZ) may lead to the development of adverse effects, including hypertension and cardiac ischemia. Whether assessment of changes in myocardial strain by two-dimensional speckle-tracking echocardiography (2D-STE) can be of value in detecting BVZ-mediated cardiotoxicity at an earlier stage is not known. We investigated whether 2D-STE can non-invasively detect early evidence of cardiotoxicity in metastatic colorectal cancer (mCRC) patients treated with BVZ. Read More

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http://dx.doi.org/10.1007/s12012-020-09583-5DOI Listing
June 2020
2.060 Impact Factor

Disruption of the Keap1/Nrf2-Antioxidant Response System After Chronic Doxorubicin Exposure In Vivo.

Cardiovasc Toxicol 2020 Jun 4. Epub 2020 Jun 4.

University of Minnesota Medical School, 1035 University Dr., Duluth, MN, 55812, USA.

Doxorubicin (DOX) is a widely prescribed anthracycline antineoplastic drug for treating human solid tumors and leukemias. However, DOX therapy is limited by a cumulative, dose-dependent, and irreversible cardiomyopathy that occurs with repeated administration. Presumably, a pivotal initiating event of DOX-induced cardiotoxicity is the production of reactive oxygen species (ROS) and oxidation of lipids, DNA, and proteins. Read More

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http://dx.doi.org/10.1007/s12012-020-09581-7DOI Listing

Concomitant Treatment with Proton Pump Inhibitors and Cephalosporins Does Not Enhance QT-Associated Proarrhythmia in Isolated Rabbit Hearts.

Cardiovasc Toxicol 2020 Jun 4. Epub 2020 Jun 4.

Department of Cardiology II (Electrophysiology), University Hospital Münster, Albert-Schweitzer-Campus 1, 48149, Münster, Germany.

Recent results from data mining analyses and reports of adverse drug events suggest a QT-prolonging drug-drug interaction resulting from the combination of distinct proton pump inhibitors and cephalosporins. Therefore, this study aimed at investigating the effect of the suspected QT-prolonging combinations of lansoprazole + ceftriaxone and esomeprazole + cefazolin, respectively. 26 hearts of New Zealand White rabbits were retrogradely perfused and paced at different cycle lengths. Read More

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http://dx.doi.org/10.1007/s12012-020-09577-3DOI Listing

Effects of Extracellular Matrix Softening on Vascular Smooth Muscle Cell Dysfunction.

Cardiovasc Toxicol 2020 Jun 4. Epub 2020 Jun 4.

Beijing Anzhen Hospital Affiliated to Capital Medical University, Beijing, 100029, China.

Vascular smooth muscle cells (VSMCs) shift from a physiological contractile phenotype to an adverse proliferative or synthetic state, which is a major event leading to aortic disease. VSMCs are exposed to multiple mechanical signals from their microenvironment including vascular extracellular matrix (ECM) stiffness and stretch which regulate VSMC contraction. How ECM stiffness regulates the function and phenotype of VSMCs is not well understood. Read More

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http://dx.doi.org/10.1007/s12012-020-09580-8DOI Listing

Comparative Cardiotoxicity of Low Doses of Digoxin, Ouabain, and Oleandrin.

Cardiovasc Toxicol 2020 Jun 1. Epub 2020 Jun 1.

Department of Veterinary Clinic and Surgery, College of Veterinary, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.

The aim of this study was to evaluate the comparative effects of CGs on heart physiology. Twenty-eight Wistar rats were distributed into four groups (n = 7), control group received NaCl 0.9% every 24 h for 21 days; treated groups received respectively 50 μg/kg of digoxin (DIG), ouabain (OUA) and oleandrin (OLE) every 24 h for 21 days. Read More

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http://dx.doi.org/10.1007/s12012-020-09579-1DOI Listing

Sudden Cardiac Arrest in an Asymptomatic Zinc Phosphide-Poisoned Patient: A Case Report.

Cardiovasc Toxicol 2020 May 25. Epub 2020 May 25.

Social Determinants of Health Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Zinc phosphide is a gray to black powder mainly used as a rodenticide. In contact with gastric fluid, it releases phosphine which is the main toxic material of this compound. Phosphine interferes with oxidative respiratory cycle of the cells, but is generally expected to manifest its toxicity with prodromal signs and symptoms including abdominal pain, nausea and vomiting, metabolic acidosis, and increased liver function tests. Read More

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http://dx.doi.org/10.1007/s12012-020-09578-2DOI Listing

The Case of Myocardial Infarction in a Fifteen-Year-Old Adolescent Caused by Toxic Substances.

Cardiovasc Toxicol 2020 May 12. Epub 2020 May 12.

Anesthesiology and Intensive Care Department, P. L. Shupyk National Medical Academy of Postgraduate Education, Kyiv, Ukraine.

The article reveals about the clinical accident of myocardial infarction in an adolescent after visiting a night club, where he had been drinking tequila. A "sniper" test was performed at home and showed synthetic marihuana in urine. The uniqueness of this case is the adolescent's difficult premorbid condition (severe diabetes mellitus type 1 and sub-compensated hypothyreosis) and the clinical course of the disease had caused difficulty in diagnosis which led to a belated hospitalization on the third day. Read More

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http://dx.doi.org/10.1007/s12012-020-09575-5DOI Listing

Ergosterol Attenuates Isoproterenol-Induced Myocardial Cardiotoxicity.

Cardiovasc Toxicol 2020 May 2. Epub 2020 May 2.

Xiamen Cardiovascular Hospital, Xiamen University, Xiamen, 361004, China.

Phytomedicine has shown a promising potential for the prevention of cardiovascular system diseases and disorders. This study aimed to evaluate protective effect of ergosterol (ER) on isoproterenol (ISO)-induced myocardial cardiotoxicity. We found that pretreatment with ER significantly decreased levels of myocardial CK-MB and LDH, and alleviated myocardial damage induced by ISO in rat model. Read More

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http://dx.doi.org/10.1007/s12012-020-09574-6DOI Listing

TRPV4 Mediates Cardiac Fibrosis via the TGF-β1/Smad3 Signaling Pathway in Diabetic Rats.

Cardiovasc Toxicol 2020 Apr 9. Epub 2020 Apr 9.

Department of Physiology, Medical College of China Three Gorges University, 8 Daxue Road, Yichang, 443002, Hubei, China.

Emerging evidence shows that the transient receptor potential vanilloid 4 (TRPV4) channel is involved in fibrosis in many organs. However, its role in diabetic cardiac fibrosis remains unclear. Our aim was to evaluate the expression level of TRPV4 in the diabetic heart and clarify its role in diabetes-induced cardiac fibrosis. Read More

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http://dx.doi.org/10.1007/s12012-020-09572-8DOI Listing
April 2020
2.060 Impact Factor

Puerarin Alleviates Lipopolysaccharide-Induced Myocardial Fibrosis by Inhibiting PARP-1 to Prevent HMGB1-Mediated TLR4-NF-κB Signaling Pathway.

Cardiovasc Toxicol 2020 Mar 31. Epub 2020 Mar 31.

Guangdong Provincial Center of Biomedical Engineering for Cardiovascular Diseases, Zhujiang Hospital, Southern Medical University, No. 1023, Shatai Nan Road, Guangzhou, 510280, China.

Myocardial fibrosis (MFs) is a crucial pathological process that results in cardiac failure in the development of multiple cardiovascular diseases. Puerarin could reportedly be used to treat a variety of cardiovascular diseases. However, the exact mechanism of puerarin on MFs was not clear enough. Read More

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http://dx.doi.org/10.1007/s12012-020-09571-9DOI Listing
March 2020
2.060 Impact Factor

The Cardioprotective Effects of Aminoguanidine on Lipopolysaccharide Induced Inflammation in Rats.

Cardiovasc Toxicol 2020 Mar 30. Epub 2020 Mar 30.

Department of Physiology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

Myocardial dysfunction, a major component of sepsis-induced multiorgan failure, contributes to the production of massive amounts of pro-inflammatory cytokines. Nitric oxide (NO) is known to act as a precursor of free radicals in inflammation. This research was conducted to assess the effect of aminoguanidine (AG) on lipopolysaccharide (LPS)-induced heart injury. Read More

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http://dx.doi.org/10.1007/s12012-020-09570-wDOI Listing

Cardioprotective Effect of Paricalcitol on Amitriptyline-Induced Cardiotoxicity in Rats: Comparison of [Tc]PYP Cardiac Scintigraphy with Electrocardiographic and Biochemical Findings.

Cardiovasc Toxicol 2020 Aug;20(4):427-436

Department of Nuclear Medicine, Faculty of Medicine, Tokat Gaziosmanpasa University, Tokat, Turkey.

Taking an overdose of AMT, a commonly prescribed tricyclic antidepressant drug, has an increased risk of sudden cardiac death. The cardiotoxicity of amitriptyline (AMT) is a commonly observed toxicity with high morbidity and mortality rates in emergency departments (ED). Nevertheless, there are still no effective treatment options for AMT-induced cardiotoxicity. Read More

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http://dx.doi.org/10.1007/s12012-020-09569-3DOI Listing

Exendin-4 Ameliorates Cardiac Remodeling in Experimentally Induced Myocardial Infarction in Rats by Inhibiting PARP1/NF-κB Axis in A SIRT1-Dependent Mechanism.

Cardiovasc Toxicol 2020 Aug;20(4):401-418

Department of Medical Laboratory Sciences, The Hashemite University, Zarqa, Jordan.

Sirt1 is a potent inhibitor of both poly(ADP-ribose) polymerases1 (PARP1) and NF-kB. This study investigated the cardioprotective effect of exendin-4 on cardiac function and remodeling in rats after an expreimentally-induced myocardial infarction (MI) and explored if this protection involves SIRT1/PARP1 axis. Rats were divided into five groups (n = 10/each): sham, sham + exendin-4 (25 nmol/kg/day i. Read More

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http://dx.doi.org/10.1007/s12012-020-09567-5DOI Listing

Electropharmacological Characterization of Aciclovir in the Halothane-Anesthetized Dogs: A Proposal of Evaluation Method for Cardiovascular Safety Pharmacology of Anti-virus Drugs.

Cardiovasc Toxicol 2020 Aug;20(4):419-426

Department of Pharmacology, Toho University Graduate School of Medicine, 5-21-16 Omori-nishi, Ota-ku, Tokyo, 143-8540, Japan.

Given limited information regarding the pathophysiology underlying aciclovir-associated, clinically observed cardiovascular adverse events including chest pain, tachycardia, bradycardia, palpitation, arrhythmia, hypertension and hypotension, we investigated its electropharmacological effects using the halothane-anesthetized beagle dogs. Aciclovir in doses of 2 and 20 mg/kg was sequentially infused over 10 min with an interval of 20 min (n = 4), which would achieve sub-therapeutic to supra-therapeutic levels of plasma concentrations. Aciclovir decreased the total peripheral vascular resistance along with the blood pressure in a dose-related manner, which increased the heart rate, ventricular contraction and atrioventricular nodal conduction speed probably via a reflex-mediated increase of sympathetic tone. Read More

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http://dx.doi.org/10.1007/s12012-020-09568-4DOI Listing

Evolution of Electrocardiographic Repolarization Parameters During Antiandrogen Therapy in Patients with Prostate Cancer and Hypogonadism.

Cardiovasc Toxicol 2020 Aug;20(4):390-400

Carol Davila University of Medicine and Pharmacy, Bucharest, Romania.

We assessed the effects of antiandrogen therapy on ECG parameters of ventricular repolarization related to arrhythmic risk in 35 patients aged 70.3 ± 7 years with advanced prostate cancer treated with degarelix associated with enzalutamide (group A, 26 patients) or degarelix monotherapy (group B, 9 patients). We analyzed Fridericia corrected Q-T interval (QTc), Q-T dispersion (QTd), J-Tpeak interval (JTp), mean and maximum Tpeak-Tend interval (Tpe) and Tpe/QT ratio, Tpeak-Tend dispersion (Tped), index of cardio-electrophysiological balance (iCEB) from ECG tracings, and occurrence of ventricular premature beats (VPB) recorded by Holter ECG, before initiation of medication (M0) and after 6 months of treatment (M1). Read More

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http://dx.doi.org/10.1007/s12012-020-09566-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7266846PMC

Mechanisms of the Cardiac Myocyte-Damaging Effects of Dasatinib.

Cardiovasc Toxicol 2020 Aug;20(4):380-389

College of Pharmacy, Apotex Centre, University of Manitoba, 750 McDermot Avenue, Winnipeg, MB, R3E 0T5, Canada.

The anticancer drug dasatinib (Sprycel) is a BCR-ABL1-targeted tyrosine kinase inhibitor used in treating chronic myelogenous leukemia that has been shown in clinical trials to display cardiovascular toxicities. While dasatinib potently inhibits BCR-ABL1, it is not a highly selective kinase inhibitor and may have off-target effects. A neonatal rat cardiac myocyte model was used to investigate potential mechanisms by which dasatinib damaged myocytes. Read More

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http://dx.doi.org/10.1007/s12012-020-09565-7DOI Listing

Human Amnion Membrane Proteins Prevent Doxorubicin-Induced Oxidative Stress Injury and Apoptosis in Rat H9c2 Cardiomyocytes.

Cardiovasc Toxicol 2020 Aug;20(4):370-379

Cardiovascular Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

Doxorubicin (DOX) is widely used as an effective chemotherapy agent in cancer treatment. Cardiac toxicity in cancer treatment with DOX demand urgent attention and no effective treatment has been established for DOX-induced cardiomyopathy. It has been well documented that human amniotic membrane proteins (AMPs), extracted from amnion membrane (AM), have antioxidant, anti-apoptotic, and cytoprotective properties. Read More

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http://dx.doi.org/10.1007/s12012-020-09564-8DOI Listing
August 2020
2.060 Impact Factor

The Effect of High Lactate Level on Mortality in Acute Heart Failure Patients With Reduced Ejection Fraction Without Cardiogenic Shock.

Cardiovasc Toxicol 2020 Aug;20(4):361-369

Department of Cardiology, Mersin University Medical Faculty, 33343, Mersin, Turkey.

Background: We aimed to determine the effect of blood lactate levels on cardiovascular (CV) death and hospitalization for heart failure (HF) in acute HF patients with reduced left ventricular ejection fraction (EF).

Methods: Eighty-five acute HF patients with reduced ejection fraction were divided into two groups according to admission blood lactate levels. 48 of them had low blood lactate levels (< 2 mmol/l) and 37 of them had high blood lactate levels (≥ 2 mmol/l). Read More

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http://dx.doi.org/10.1007/s12012-020-09563-9DOI Listing

Various Manifestations of 5-Fluorouracil Cardiotoxicity: A Multicenter Case Series and Review of Literature.

Cardiovasc Toxicol 2020 Aug;20(4):437-442

Section of Cardiology, Department of Medicine, Baylor College of Medicine, One Baylor Plaza, Houston, TX, 77030, USA.

5-Fluorouracil is a key element to the treatment of colon cancer. But it is also one of the most cardiotoxic chemotherapies, and the management of those that experience cardiotoxicity can be challenging. We present three cases of 5-FU cardiac toxicity that manifested as myocardial infarction, cardiogenic shock, and ventricular fibrillation. Read More

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http://dx.doi.org/10.1007/s12012-020-09562-wDOI Listing
August 2020
2.060 Impact Factor

How the Deuteration of Dronedarone Can Modify Its Cardiovascular Profile: In Vivo Characterization of Electropharmacological Effects of Poyendarone, a Deuterated Analogue of Dronedarone.

Cardiovasc Toxicol 2020 Aug;20(4):339-350

Department of Pharmacology, Faculty of Medicine, Toho University, 5-21-16 Omori-nishi, Ota-ku, Tokyo, 143-8540, Japan.

Since deuterium replacement has a potential to modulate pharmacodynamics, pharmacokinetics and toxicity, we developed deuterated dronedarone; poyendarone, and assessed its cardiovascular effects. Poyendarone hydrochloride in doses of 0.3 and 3 mg/kg over 30 s was intravenously administered to the halothane-anesthetized dogs (n = 4), which provided peak plasma concentrations of 108 ± 10 and 1120 ± 285 ng/mL, respectively. Read More

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http://dx.doi.org/10.1007/s12012-019-09559-0DOI Listing

Rho Kinase Inhibition by Fasudil Attenuates Adriamycin-Induced Chronic Heart Injury.

Cardiovasc Toxicol 2020 Aug;20(4):351-360

Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University, No. 300, Guangzhou Road, Nanjing, China.

Adriamycin (ADR)-induced chronic heart injury (CHI) is a serious complication of chemotherapy. The present study was designed to assess the ability of fasudil, a Rho kinase inhibitor, to prevent ADR-induced CHI. Forty male 6-week-old C57BL6 mice were randomly divided into the following four groups: (1) control group, (2) CHI induced by adriamycin (ADR group), (3) CHI plus low dose fasudil (ADR + L group), and (4) CHI plus high dose fasudil (ADR + H group). Read More

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http://dx.doi.org/10.1007/s12012-019-09561-6DOI Listing

Myocardial Repolarization Parameters and Neutrophil-to-Lymphocyte Ratio are Associated with Cardiotoxicity in Carbon Monoxide Poisoning.

Cardiovasc Toxicol 2020 Apr;20(2):190-196

Department of Emergency Medicine, Gulhane Education and Research Hospital, University of Health Scicences, Ankara, Turkey.

The present study aims to examine the clinical values of complete blood count (CBC) bioindicators and corrected QT (QT), T - T interval (T), T (T), and T/QT ratio that are the parameters of myocardial repolarization (M-rep) for cardiotoxicity, which develops due to acute carbon monoxide (CO) intoxication in patients admitted to the emergency service. This retrospective, cross-sectional, observational, and single-center study was conducted between April and June 2019. Statistical analysis was performed using the SPSS 23. Read More

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http://dx.doi.org/10.1007/s12012-019-09560-7DOI Listing

Cardioprotective Effects and Duration of Beta Blocker Therapy in Anthracycline-Treated Patients: A Systematic Review and Meta-analysis.

Cardiovasc Toxicol 2020 Feb;20(1):11-19

Department of Cardiology, The First Affiliated Hospital of Chongqing Medical University, 1 Youyi Road, Yuzhong, Chongqing, 400016, People's Republic of China.

Anthracycline-containing chemotherapy is commonly associated with irreversible cardiovascular toxicity. Beta blockers are currently recommended as first-line drugs for improving cardiac function. However, the effects of beta blocker on cardiac preservation and the duration of beta blocker intervention therapy in anthracycline-treated patients remain unclear. Read More

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http://dx.doi.org/10.1007/s12012-019-09558-1DOI Listing
February 2020

The Effects of Neuropeptide Y Overexpression on the Mouse Model of Doxorubicin-Induced Cardiotoxicity.

Cardiovasc Toxicol 2020 Jun;20(3):328-338

Heart Centre, Turku University Hospital and University of Turku, Turku, Finland.

Doxorubicin is a potent anticancer drug with cardiotoxicity hampering its use. Neuropeptide Y (NPY) is the most abundant neuropeptide in the heart and a co-transmitter of the sympathetic nervous system that plays a role in cardiac diseases. The aim of this work was to study the impact of NPY on doxorubicin-induced cardiotoxicity. Read More

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http://dx.doi.org/10.1007/s12012-019-09557-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7176599PMC

Platelet Function in Cardiovascular Disease: Activation of Molecules and Activation by Molecules.

Authors:
Elahe Khodadi

Cardiovasc Toxicol 2020 Feb;20(1):1-10

Health Research Institute, Research Center of Thalassemia & Hemoglobinopathy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Globally, one of the major causes of death is the cardiovascular disease (CVD), and platelets play an important role in thrombosis and atherosclerosis that led to death. Platelet activation can be done by different molecules, genes, pathways, and chemokines. Lipids activate platelets by inflammatory factors, and platelets are activated by receptors of peptide hormones, signaling and secreted proteins, microRNAs (miRNAs), and oxidative stress which also affect the platelet activation in older age. Read More

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http://dx.doi.org/10.1007/s12012-019-09555-4DOI Listing
February 2020

Impact of Arterial Hypertension on Doxorubicin-Based Chemotherapy-Induced Subclinical Cardiac Damage in Breast Cancer Patients.

Cardiovasc Toxicol 2020 Jun;20(3):321-327

Department of Oncology and Hematology, Medical Academy, Lithuanian University of Health Sciences, A. Mickeviciaus Str. 9, 44307, Kaunas, Lithuania.

Advances in oncologic therapies have allowed to achieve better outcomes and longer survival in many patients with breast cancer. Anthracyclines are cytotoxic antibiotics widely used in daily oncology practice. However, anthracyclines cause cardiotoxicity which is a limiting factor of its use. Read More

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http://dx.doi.org/10.1007/s12012-019-09556-3DOI Listing

The Role of Topoisomerase IIβ in the Mechanisms of Action of the Doxorubicin Cardioprotective Agent Dexrazoxane.

Cardiovasc Toxicol 2020 Jun;20(3):312-320

College of Pharmacy, Apotex Centre, University of Manitoba, 750 McDermot Avenue, Winnipeg, MB, R3E 0T5, Canada.

Dexrazoxane is clinically used to reduce doxorubicin cardiotoxicity and anthracycline-induced extravasation injury. Dexrazoxane is a strong catalytic inhibitor of topoisomerase II. It can also undergo metabolism to form an iron-binding analog of EDTA. Read More

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http://dx.doi.org/10.1007/s12012-019-09554-5DOI Listing

Effects of Hyperbaric Oxygen Therapy on Acute Myocardial Infarction Following Carbon Monoxide Poisoning.

Cardiovasc Toxicol 2020 Jun;20(3):291-300

Department of Environmental and Occupational Health, College of Medicine, National Cheng Kung University, 1 Daxue Road, East District, Tainan, 701, Taiwan.

Carbon monoxide poisoning (COP) may increase the risk of myocardial infarction. We conducted a study to investigate the effects of hyperbaric oxygen therapy (HBOT) on the risk. We used the Nationwide Poisoning Database in Taiwan to identify COP patients diagnosed between 1999 and 2012. Read More

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http://dx.doi.org/10.1007/s12012-019-09552-7DOI Listing

Assessment of Pregabalin-Induced Cardiotoxicity in Rats: Mechanistic Role of Angiotensin 1-7.

Cardiovasc Toxicol 2020 Jun;20(3):301-311

Department of Pharmacology and Toxicology, Faculty of Pharmacy, Cairo University, Cairo, Egypt.

Pregabalin (PRG) possesses great therapeutic benefits in the treatment of epilepsy, neuropathic pain, and fibromyalgia. However, clinical data have reported incidence or exacerbation of heart failure following PRG administration. Experimental data exploring cardiac alterations and its underlying mechanisms are quite scarce. Read More

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http://dx.doi.org/10.1007/s12012-019-09553-6DOI Listing
June 2020
2.060 Impact Factor

Protective Effect of RIVA Against Sunitinib-Induced Cardiotoxicity by Inhibiting Oxidative Stress-Mediated Inflammation: Probable Role of TGF-β and Smad Signaling.

Cardiovasc Toxicol 2020 Jun;20(3):281-290

Department of Pharmacology, College of Pharmacy, Jouf University, Sakakah, 72341, Saudi Arabia.

Sunitinib (SUN) is an oral tyrosine kinase inhibitor approved in 2006 as a first-line treatment for metastatic renal cell cancer. However, weak selectivity to kinase receptors and cardiotoxicity have limited the use of sunitinib. Rivaroxaban (RIVA) is a Factor Xa inhibitor with cardioprotective action. Read More

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http://dx.doi.org/10.1007/s12012-019-09551-8DOI Listing
June 2020
1 Read

Oleic Acid Protects from Arsenic-Induced Cardiac Hypertrophy via AMPK/FoxO/NFATc3 Pathway.

Cardiovasc Toxicol 2020 Jun;20(3):261-280

Department of Life science and Biotechnology, Jadavpur University, 188, Raja S. C. Mallick Road, Kolkata, West Bengal, 700032, India.

Arsenic toxicity is one of the major environmental problems causing various diseases, cardiovascular disorders is one of them. Several epidemiological studies have shown that arsenic causes cardiac hypertrophy but the detailed molecular mechanism is to be studied yet. This study is designed to determine the molecules involved in the augmentation of arsenic-induced cardiac hypertrophy. Read More

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http://dx.doi.org/10.1007/s12012-019-09550-9DOI Listing
June 2020
2 Reads

Late-life Cardiac Injury in Rats following Early Life Exposure to Lead: Reversal Effect of Nutrient Metal Mixture.

Cardiovasc Toxicol 2020 Jun;20(3):249-260

Department of Zoology, Sri Venkateswara University, Tirupati, Andhra Pradesh, 517502, India.

Early-life exposure to lead (Pb) can lead to health effects in later life. The neurotoxic effects of Pb have been well documented but its effects on the heart are poorly elucidated. We examined the late life cardiac impairments resulting from developmental exposure to Pb. Read More

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http://dx.doi.org/10.1007/s12012-019-09549-2DOI Listing

Arbutin Attenuates Isoproterenol-Induced Cardiac Hypertrophy by Inhibiting TLR-4/NF-κB Pathway in Mice.

Cardiovasc Toxicol 2020 Jun;20(3):235-248

Department of Applied Biology, CSIR-Indian Institute of Chemical Technology (IICT), Hyderabad, 500 007, India.

Arbutin is a glycoside reported for its anti-oxidant, anti-inflammatory and anti-tumor properties. However, the cardioprotective effect of Arbutin is not well established. The study aims to understand the effect of arbutin on isoproterenol (ISO)-induced cardiac hypertrophy in mice. Read More

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http://dx.doi.org/10.1007/s12012-019-09548-3DOI Listing
June 2020
1 Read

Coenzyme Q10 Cardioprotective Effects Against Doxorubicin-Induced Cardiotoxicity in Wistar Rat.

Cardiovasc Toxicol 2020 Jun;20(3):222-234

Laboratório de Toxicologia Veterinária, Departamento de Clínica e Cirurgia Veterinárias, Escola de Veterinária, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.

In the present study, we investigated the cardioprotective effects of coenzyme Q10 (Q10) against doxorubicin (DOXO) induced cardiomyopathy. Twenty adult rats were distributed in four experimental groups: group 1 received NaCl 0.9% at 1 ml/day for 14 days; group 2 received Q10 at 1 mg/kg/day for 14 days; group 3 received initial 7 days of treatment with NaCl 0. Read More

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http://dx.doi.org/10.1007/s12012-019-09547-4DOI Listing

Vehicular Particulate Matter (PM) Characteristics Impact Vascular Outcomes Following Inhalation.

Cardiovasc Toxicol 2020 Jun;20(3):211-221

Department of Pharmaceutical Sciences, The University of New Mexico, College of Pharmacy, Albuquerque, NM, USA.

Roadside proximity and exposure to mixed vehicular emissions (MVE) have been linked to adverse pulmonary and vascular outcomes. However, because of the complex nature of the contribution of particulate matter (PM) versus gases, it is difficult to decipher the precise causative factors regarding PM and the copollutant gaseous fraction. To this end, C57BL/6 and apolipoprotein E knockout mice (ApoE) were exposed to either filtered air (FA), fine particulate (FP), FP+gases (FP+G), ultrafine particulate (UFP), or UFP+gases (UFP+G). Read More

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http://dx.doi.org/10.1007/s12012-019-09546-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7015791PMC

Lipocalin-2 Predicts Long-Term Outcome of Normotensive Patients with Acute Pulmonary Embolism.

Cardiovasc Toxicol 2020 Apr;20(2):101-110

Beijing Anzhen Hospital, Capital Medical University, No. 2 Anzhen Road, Chaoyang District, Beijing, 100029, China.

Normotensive patients with acute pulmonary embolism (APE) are accompanied by heterogeneously adverse events. Responding to tissue injury, lipocalin-2 (LCN-2) is elevated in experimental APE model and associated with short-term prognosis. However, the prognostic value of LCN-2 in normotensive patients with APE for long-term major adverse events (MAEs) remains unknown. Read More

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http://dx.doi.org/10.1007/s12012-019-09525-wDOI Listing
April 2020
3 Reads

Chronic Mercury Exposure in Prehypertensive SHRs Accelerates Hypertension Development and Activates Vasoprotective Mechanisms by Increasing NO and HO Production.

Cardiovasc Toxicol 2020 Jun;20(3):197-210

Department of Physiological Sciences, Federal University of Espirito Santo, Av. Marechal Campos, 1468, Vitória, ES, CEP 29040-091, Brazil.

Mercury is a heavy metal associated with cardiovascular diseases. Studies have reported increased vascular reactivity without changes in systolic blood pressure (SBP) after chronic mercury chloride (HgCl) exposure, an inorganic form of the metal, in normotensive rats. However, we do not know whether individuals in the prehypertensive phase, such as young spontaneously hypertensive rats (SHRs), are susceptible to increased arterial blood pressure. Read More

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http://dx.doi.org/10.1007/s12012-019-09545-6DOI Listing

Association of Genetic Variations in NRF2, NQO1, HMOX1, and MT with Severity of Coronary Artery Disease and Related Risk Factors.

Cardiovasc Toxicol 2020 Apr;20(2):176-189

Department of Pathology, Faculty of Medicine, Khon Kaen University, Khon Kaen, 40002, Thailand.

NRF2 is a transcription factor which, during oxidative stress, activates transcription of its target antioxidant genes. Polymorphisms in NRF2 and its target antioxidant genes: HMOX-1, NQO1, and MT, have been associated with cardiovascular diseases (CVDs) and diabetes in various ethnic groups, however, with variable results. The aim of this study was to investigate the association of NRF2, HMOX-1, NQO1, and MT gene polymorphisms with CVD risk factors in Thais. Read More

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http://dx.doi.org/10.1007/s12012-019-09544-7DOI Listing
April 2020
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Mechanism of Hydrogen Sulfide Preconditioning-Associated Protection Against Ischemia-Reperfusion Injury Differs in Diabetic Heart That Develops Myopathy.

Cardiovasc Toxicol 2020 Apr;20(2):155-167

Vascular Biology Lab (ASK 1, 117), School of Chemical and Biotechnology, SASTRA Deemed to be University, Thanjavur, India.

Hydrogen sulfide (HS) is reported to be effective in the management of the myocardial ischemia-reperfusion (I/R) injury via PI3K/GSK3β pathway in normal rats. However, its efficacy against I/R in the presence of diabetic cardiomyopathy is relatively obscure. Thus, the present work aimed to find out HS-mediated cardioprotection against I/R in diabetic cardiomyopathy and to evaluate its mode of action using Langendorff isolated heart perfusion system. Read More

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http://link.springer.com/10.1007/s12012-019-09542-9
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http://dx.doi.org/10.1007/s12012-019-09542-9DOI Listing
April 2020
2 Reads

Proarrhythmic Effect of Acetylcholine-Esterase Inhibitors Used in the Treatment of Alzheimer's Disease: Benefit of Rivastigmine in an Experimental Whole-Heart Model.

Cardiovasc Toxicol 2020 Apr;20(2):168-175

Department of Cardiology II (Electrophysiology), University Hospital Münster, Albert-Schweitzer-Campus 1, 48149, Münster, Germany.

Several studies suggest QT prolongation and torsade de pointes with acetylcholine-esterase inhibitors. We therefore examined the electrophysiologic profile of donepezil, rivastigmine, and galantamine in a sensitive whole-heart model of proarrhythmia. 34 rabbit hearts were isolated and retrogradely perfused employing the Langendorff setup. Read More

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http://dx.doi.org/10.1007/s12012-019-09543-8DOI Listing
April 2020
8 Reads

The Protective Effects of Pharmacologic Postconditioning of Hydroalcoholic Extract of Nigella sativa on Functional Activities and Oxidative Stress Injury During Ischemia-Reperfusion in Isolated Rat Heart.

Cardiovasc Toxicol 2020 Apr;20(2):130-138

Department of Physiology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, 9177948564, Iran.

Oxidative stress is known to act as the trigger of cardiac damage during ischemia-reperfusion (I/R) injury. Postconditioning (PoC) is employed to minimize the consequences of ischemia at the onset of reperfusion. Regarding the well-known antioxidant properties of Nigella sativa (Ns), the aim of this study was to investigate whether Nigella sativa postconditioning (Ns-PoC) could reduce IRI by lowering the formation of reactive oxygen species (ROS). Read More

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http://dx.doi.org/10.1007/s12012-019-09540-xDOI Listing

Dasatinib can Impair Left Ventricular Mechanical Function But May Lack Proarrhythmic Effect: A Proposal of Non-clinical Guidance for Predicting Clinical Cardiovascular Adverse Events of Tyrosine Kinase Inhibitors.

Cardiovasc Toxicol 2020 Feb;20(1):58-70

Department of Pharmacology, Faculty of Medicine, Toho University, 5-21-16 Omori-nishi, Ota-ku, Tokyo, 143-8540, Japan.

Tyrosine kinase inhibitors are known to clinically induce various types of cardiovascular adverse events; however, it is still difficult to predict them at preclinical stage. In order to explore how to better predict such drug-induced cardiovascular adverse events, we tried to develop a new protocol by assessing acute electrophysiological, cardiohemodynamic, and cytotoxic effects of dasatinib in vivo and in vitro. Dasatinib at 0. Read More

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http://dx.doi.org/10.1007/s12012-019-09538-5DOI Listing
February 2020

FOLFIRI-Mediated Toxicity in Human Aortic Smooth Muscle Cells and Possible Amelioration with Curcumin and Quercetin.

Cardiovasc Toxicol 2020 Apr;20(2):139-154

Department of Medical Biology, Faculty of Medicine, Trakya University, 22030, Edirne, Turkey.

Systemic chemotherapy-mediated cell toxicity is a major risk factor for cardiovascular disease and atherosclerosis. Life-threatening acute events of the FOLFIRI (irinotecan, folinic acid and 5-fluorouracil) regimen are mainly due to DNA damage induced by antimetabolite and topoisomerase inhibition effects. However, the role of human aortic smooth muscle cells (HaVSMCs) in this process and the mechanisms of oxidative stress, DNA and protein damage and apoptosis have not been investigated. Read More

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http://dx.doi.org/10.1007/s12012-019-09541-wDOI Listing
April 2020
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Cocaine in Hospital Admissions for Diseases of the Circulatory System and as the Underlying Cause of Death: Analysis and Discussion.

Cardiovasc Toxicol 2020 Feb;20(1):20-27

Unit of Legal Medicine, Department of Physiology and Pharmacology, University of Cantabria, C/Cardenal Herrera Oria s/n, 39011, Santander, Spain.

Cocaine is a cardiotoxic drug which has been associated with morbi-mortality due to cardiovascular diseases (CVD). This study aims to: (1) analyze the hospitalizations due to cardiovascular processes and the presence of cocaine among the toxic habits of patients; and (2) discuss the forensic difficulties in sudden cardiac death (SCD) in the presence of cocaine. Hospital discharges due to CVD reporting cocaine consumption as a secondary diagnosis between 2003 and 2013 in Spain were analyzed. Read More

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http://dx.doi.org/10.1007/s12012-019-09537-6DOI Listing
February 2020
2 Reads

Suppression of LPS-Induced Hepato- and Cardiotoxic Effects by Pulicaria petiolaris via NF-κB Dependent Mechanism.

Cardiovasc Toxicol 2020 Apr;20(2):121-129

Department of Pharmacognosy and Pharmaceutical Chemistry, College of Pharmacy, Taibah University, Al Madinah Al Munawwarah, 30078, Saudi Arabia.

Recently, there is an increasing interest in searching for harmless natural products isolated from plant materials that can be used as beneficial dietary supplements and/or therapeutic drug candidates. The present study aimed to test the potential protective role of Pulicaria petiolaris (PP, Asteraceae) against hepatic and cardiotoxic effects associated with lipopolysaccharide (LPS) injection. PP was given orally for 5 days at two different doses before LPS injection. Read More

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http://dx.doi.org/10.1007/s12012-019-09539-4DOI Listing
April 2020
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The Effects of Thiamine Hydrochloride on Cardiac Function, Redox Status and Morphometric Alterations in Doxorubicin-Treated Rats.

Cardiovasc Toxicol 2020 Apr;20(2):111-120

Department of Pharmacy, Faculty of Medical Sciences, University of Kragujevac, Svetozara Markovica 69, 34000, Kragujevac, Serbia.

Previous studies have suggested that thiamine has antioxidant activity and could decrease the production of ROS in various disorders. Our study focused on the effect of thiamine hydrochloride in the reversal of DOX-induced cardiotoxicity and compared it with the reversal in the absence of thiamine pre-treatment. Rats were divided into groups as follows: (a) thiamine + doxorubicin (TIA + DOX), (b) doxorubicin (DOX) and c) healthy (CTRL) groups. Read More

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http://dx.doi.org/10.1007/s12012-019-09536-7DOI Listing