694 results match your criteria Cardiovascular toxicology[Journal]


Fulminant Vascular and Cardiac Toxicity Associated with Tyrosine Kinase Inhibitor Sorafenib.

Cardiovasc Toxicol 2018 Dec 12. Epub 2018 Dec 12.

Department of Cardiology, The University of Texas MD Anderson Cancer Center, 1400 Pressler Street, 1451, 77030, Houston, TX, USA.

The use of vascular endothelial growth factor inhibitors such as sorafenib is limited by a risk of severe cardiovascular toxicity. A 28-year-old man with acute myeloid leukemia treated with prednisone, tacrolimus, and sorafenib following stem cell transplantation presented with severe bilateral lower extremity claudication. The patient was discharged against medical advice prior to finalizing a cardiovascular evaluation, but returned 1 week later with signs suggestive of septic shock. Read More

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http://dx.doi.org/10.1007/s12012-018-9499-2DOI Listing
December 2018

Cobalt Administration Causes Reduced Contractility with Parallel Increases in TRPC6 and TRPM7 Transporter Protein Expression in Adult Rat Hearts.

Cardiovasc Toxicol 2018 Dec 6. Epub 2018 Dec 6.

Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, G4 0RE, Scotland, UK.

Exposure to circulating cobalt (Co) in patients with metal-on-metal orthopaedic hip implants has been linked to cardiotoxicity but the underlying mechanism(s) remain undefined. The aim of the current study was to examine the effects of Co on the heart in vivo and specifically on cardiac fibroblasts in vitro. Adult male rats were treated with CoCl (1 mg/kg) for either 7 days or 28 days. Read More

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http://dx.doi.org/10.1007/s12012-018-9498-3DOI Listing
December 2018

MiR-15b-5p is Involved in Doxorubicin-Induced Cardiotoxicity via Inhibiting Bmpr1a Signal in H9c2 Cardiomyocyte.

Cardiovasc Toxicol 2018 Dec 7. Epub 2018 Dec 7.

Department of Cardiology, The Second Affiliated Hospital of Shantou University Medical College, Dongxia North Road, Shantou, 515041, Guangdong, People's Republic of China.

The wide use of anthracyclines represented by doxorubicin (DOX) has benefited cancer patients, yet the clinical application is limited due to its cardiotoxicity. Although numerous evidences have supported a role of microRNAs (miRNAs) in DOX-induced myocardial damage, the exact etiology and pathogenesis remain largely obscure. In this study, we focused on the role of miR-15b-5p in DOX-induced cardiotoxicity. Read More

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http://dx.doi.org/10.1007/s12012-018-9495-6DOI Listing
December 2018

Ischemic Preconditioning Efficacy Following Anabolic Steroid Usage: A Clear Difference Between Sedentary and Exercise-Trained Rat Hearts.

Cardiovasc Toxicol 2018 Dec 7. Epub 2018 Dec 7.

Department of Physiology, Faculty of Medicine, Bushehr University of Medical Sciences, Bushehr, Iran.

Previous studies show that anabolic steroids impair innate cardioprotective mechanisms. Here, we investigated the effect of supraphysiological doses of nandrolone on ischemic preconditioning (IPC) as a potent cardioprotective tool against ischemia reperfusion (IR) injury in rat hearts. Male Wistar rats in two experimental settings of sedentary and exercise-trained (60 min/day swimming, 5 days/week, for 8 weeks) were either pretreated with intramuscular injections of arachis oil (Arach, n = 16) as vehicle or nandrolone decanoate (ND, n = 8), 10 mg/kg/week, for 8 weeks. Read More

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http://dx.doi.org/10.1007/s12012-018-9497-4DOI Listing
December 2018

Vildagliptin, an Anti-diabetic Drug of the DPP-4 Inhibitor, Induces Vasodilation via Kv Channel and SERCA Pump Activation in Aortic Smooth Muscle.

Cardiovasc Toxicol 2018 Dec 5. Epub 2018 Dec 5.

Department of Physiology, Kangwon National University School of Medicine, 1 Kangwondaehak-gil, Chuncheon, 24341, South Korea.

This study investigated vildagliptin-induced vasodilation and its related mechanisms using phenylephrine induced precontracted rabbit aortic rings. Vildagliptin induced vasodilation in a concentration-dependent manner. Pretreatment with the large-conductance Ca-activated K channel blocker paxilline, ATP-sensitive K channel blocker glibenclamide, and inwardly rectifying K channel blocker Ba did not affect the vasodilatory effects of vildagliptin. Read More

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http://link.springer.com/10.1007/s12012-018-9496-5
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http://dx.doi.org/10.1007/s12012-018-9496-5DOI Listing
December 2018
4 Reads
2.060 Impact Factor

Endothelial Cells: From Dysfunction Mechanism to Pharmacological Effect in Cardiovascular Disease.

Cardiovasc Toxicol 2018 Dec 1. Epub 2018 Dec 1.

Thalassemia and Hemoglobinopathy Research Center, Research Institute of Health, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Endothelial cells (ECs) are the innermost layer of blood vessels that play important roles in homeostasis and vascular function. However, recent evidence suggests that the onset of inflammation and the production of reactive oxygen species impair the function of ECs and are a main factor in the development of cardiovascular disease (CVD). In this study, we investigated the effects of inflammatory markers, oxidative stress, and treatment on ECs in CVD patients. Read More

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http://link.springer.com/10.1007/s12012-018-9493-8
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http://dx.doi.org/10.1007/s12012-018-9493-8DOI Listing
December 2018
11 Reads

Digitalis Promotes Ventricular Arrhythmias in Flecainide- and Ranolazine-Pretreated Hearts.

Cardiovasc Toxicol 2018 Dec 4. Epub 2018 Dec 4.

Department of Cardiology II - Electrophysiology, University Hospital Münster, Münster, Germany.

A post hoc analysis of the PALLAS trial suggested life-threatening interactions of digitalis and dronedarone. Thus, there is concern about an interplay between digitalis and other drugs that influence cardiac electrophysiology. We therefore investigated the interaction between digitalis and flecainide or ranolazine. Read More

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http://dx.doi.org/10.1007/s12012-018-9494-7DOI Listing
December 2018
1 Read

Cyclosporine Metabolites' Metabolic Ratios May Be Markers of Cardiovascular Disease in Kidney Transplant Recipients Treated with Cyclosporine A-Based Immunosuppression Regimens.

Cardiovasc Toxicol 2018 Nov 23. Epub 2018 Nov 23.

Department of Immunology, Transplant Medicine and Internal Diseases, Medical University of Warsaw, 59 Nowogrodzka St, Warsaw, Poland.

Cardiovascular disease (CVD) remains one of the primary causes of death after kidney transplantation (KTX). Cyclosporine (CsA) metabolites may play a role in CVD. Metabolic ratio (MR) may be considered a measure of intra-individual differences of CsA metabolism. Read More

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http://dx.doi.org/10.1007/s12012-018-9492-9DOI Listing
November 2018
3 Reads

Nano-medicine and Vascular Endothelial Dysfunction: Options and Delivery Strategies.

Cardiovasc Toxicol 2018 Nov 17. Epub 2018 Nov 17.

Cardiovascular Division, Department of Pharmacology, Amity Institute of Pharmacy, Amity University, Gurugram, Haryana, 122051, India.

The endothelium is a thin innermost layer of flat cells which release various mediators including endothelin-1 (ET-1), prostanoids, von Willebrand factor (vWF) and endothelium-derived relaxing factor (EDRF; nitric oxide) to regulate vascular tone. Endothelial nitric oxide synthase (eNOS) is a key enzyme that generates nitric oxide (NO). NO maintains vascular homeostasis and cardiac functions by influencing major vascular protective properties such as anti-platelet, anti-proliferative, anti-migratory, antioxidant and anti-inflammatory action in vessels. Read More

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http://link.springer.com/10.1007/s12012-018-9491-x
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http://dx.doi.org/10.1007/s12012-018-9491-xDOI Listing
November 2018
6 Reads

Effects of Ambient Atmospheric PM, 1-Nitropyrene and 9-Nitroanthracene on DNA Damage and Oxidative Stress in Hearts of Rats.

Cardiovasc Toxicol 2018 Nov 12. Epub 2018 Nov 12.

State Key Laboratory of Environmental and Biological Analysis, Department of Chemistry, Hong Kong Baptist University, Kowloon Tong, Jiulong, Hong Kong SAR, China.

Exposure to fine particulate matter (PM) increased the risks of cardiovascular diseases. PM-bound 1-nitropyrene (1-NP) and 9-nitroanthracene (9-NA) are released from the incomplete combustion of fossil fuels and derived from polycyclic aromatic hydrocarbons (PAHs). The toxicities of 1-NP and 9-NA are mainly reflected in their carcinogenicity and mutagenicity. Read More

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http://link.springer.com/10.1007/s12012-018-9488-5
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http://dx.doi.org/10.1007/s12012-018-9488-5DOI Listing
November 2018
4 Reads

Cardiotoxicity of Pesticides: Are Africans at Risk?

Authors:
Raphael Anakwue

Cardiovasc Toxicol 2018 Nov 7. Epub 2018 Nov 7.

Department of Medicine, Department of Pharmacology/Therapeutics, Faculty of Medical Sciences, University of Nigeria, University of Nigeria Teaching Hospital, Enugu, Nigeria.

Cardiovascular disease has maintained the unenviable position as the number one cause of death in the world. It is now clear that the traditional risk factors of cardiovascular disease are driven by primary factors like globalisation, urbanisation, industrialisation and agricultural practices. Pesticide use is an integral component of modern and improved agriculture. Read More

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http://link.springer.com/10.1007/s12012-018-9486-7
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http://dx.doi.org/10.1007/s12012-018-9486-7DOI Listing
November 2018
4 Reads

Limb Blood Flow Restriction Plus Mild Aerobic Exercise Training Protects the Heart Against Isoproterenol-Induced Cardiac Injury in Old Rats: Role of GSK-3β.

Cardiovasc Toxicol 2018 Nov 7. Epub 2018 Nov 7.

Department of Physical Education, Faculty of Shahid Chamran, Kerman Branch, Technical and Vocational University (YVU), Tehran, Iran.

The present study was conducted to evaluate the effect of blood flow restriction (BFR) training on cardiac resistance to isoproterenol (ISO) induced heart injury in old rats and examined the hypothesis that BFR training may interfere with age-associated impairment of mitochondria by the inhibitory phosphorylation of GSK-3β at Ser9. Old male Wistar rats were divided into the following six groups: CTL (control), ISO (isoproterenol-treated), Sh + ISO (sham-operated plus ISO), BFR + ISO (blood flow restriction plus ISO), Sh-Ex + ISO (sham-operated subjected to exercise and ISO), and BFR-Ex + ISO (blood flow restriction along with exercise and ISO). 10 weeks of exercise training was considered. Read More

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http://link.springer.com/10.1007/s12012-018-9490-y
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http://dx.doi.org/10.1007/s12012-018-9490-yDOI Listing
November 2018
5 Reads

Airway Exposure to Modified Multi-walled Carbon Nanotubes Perturbs Cardiovascular Adenosinergic Signaling in Mice.

Cardiovasc Toxicol 2018 Oct 31. Epub 2018 Oct 31.

College of Health Professions, School of Movement and Rehabilitation Sciences, Bellarmine University, 2001 Newburg Road, Louisville, KY, 40205, USA.

The broad list of commercial applications for multi-walled carbon nanotubes (MWCNT) can be further expanded with the addition of various surface chemistry modifications. For example, standard commercial grade MWCNT (C-grade) can be carboxylated (COOH) or nitrogen-doped (N-doped) to suite specific utilities. We previously reported dose-dependent expansions of cardiac ischemia/reperfusion (I/R) injury, 24 h after intratracheal instillation of C-grade, COOH, or N-doped MWCNT in mice. Read More

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http://link.springer.com/10.1007/s12012-018-9487-6
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http://dx.doi.org/10.1007/s12012-018-9487-6DOI Listing
October 2018
2 Reads

Methoxetamine Induces Cytotoxicity in H9c2 Cells: Possible Role of p21 Protein (Cdc42/Rac)-Activated Kinase 1.

Cardiovasc Toxicol 2018 Oct 30. Epub 2018 Oct 30.

College of Pharmacy and Medical Research Center, Chungbuk National University, 194-31 Osongsaemgmyeong 1-ro, Osong-eup, Heungdeok-gu, Cheongju-si, Chungbuk, 28160, Republic of Korea.

The abuse of new psychoactive substances (NPS) is an emerging social problem. Methoxetamine, one of the NPS, was designed as an alternative to ketamine and it was considered an NPS candidate owing to its high addictive potential. However, cardiotoxicity of the phencyclidine analogue, methoxetamine, has not been extensively evaluated. Read More

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http://dx.doi.org/10.1007/s12012-018-9489-4DOI Listing
October 2018
1 Read

Phenolic Metabolites Modulate Cardiomyocyte Beating in Response to Isoproterenol.

Cardiovasc Toxicol 2018 Oct 9. Epub 2018 Oct 9.

CEDOC, NOVA Medical School, Faculdade de Ciências Médicas, Universidade Nova de Lisboa, Campo Mártires da Pátria, 130, 1169-056, Lisboa, Portugal.

Cardiovascular disease (CVD) is a public health concern, and the third cause of death worldwide. Several epidemiological studies and experimental approaches have demonstrated that consumption of polyphenol-enriched fruits and vegetables can promote cardioprotection. Thus, diet plays a key role in CVD development and/or prevention. Read More

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http://link.springer.com/10.1007/s12012-018-9485-8
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http://dx.doi.org/10.1007/s12012-018-9485-8DOI Listing
October 2018
20 Reads

Pregnancy-Associated Plasma Protein A (PAPP-A) Concentration in Population of Healthy Young People: Interactions with Tobacco Smoke and Anti-oxidative Status.

Cardiovasc Toxicol 2018 Oct 9. Epub 2018 Oct 9.

Department of Chemistry, School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia, Katowice, Poland.

Pregnancy-associated plasma protein A (PAPP-A) is a high-molecular zinc-binding metalloproteinase that was first detected in the serum of pregnant women. It can also be detected in men and non-pregnant women. Recently, a growing interest in determining the concentration of PAPP-A as a marker of oxidative stress and atherosclerotic processes has been observed. Read More

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http://link.springer.com/10.1007/s12012-018-9479-6
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http://dx.doi.org/10.1007/s12012-018-9479-6DOI Listing
October 2018
2 Reads

Risk of Myocardial Infarction After Carbon Monoxide Poisoning: A Nationwide Population-Based Cohort Study.

Cardiovasc Toxicol 2018 Sep 22. Epub 2018 Sep 22.

Department of Environmental and Occupational Health, College of Medicine, National Cheng Kung University, 1 Daxue Road, East District, Tainan City 701, Tainan, Taiwan.

Carbon monoxide poisoning (COP) may lead to ischemic changes in organs, and heart is one of the most susceptible targets to ischemic condition. The objective of this study is to evaluate the risk of myocardial infarction following COP. Using a nationwide database of insurance claims in Taiwan, we conducted a population-based cohort study to identify COP patients diagnosed between 1999 and 2012. Read More

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http://dx.doi.org/10.1007/s12012-018-9484-9DOI Listing
September 2018

Late Cardiac Complications of Sulfur Mustard Poisoning in 38 Iranian Veterans.

Cardiovasc Toxicol 2018 Sep 21. Epub 2018 Sep 21.

School of Medicine, Medical Toxicology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

It was aimed to investigate possible late cardiac effects of Sulfur mustard (SM) exposure in Iranian veterans. Thirty-eight veterans with late complications of SM exposure were investigated. Clinical history, physical examinations, 12 leads electrocardiography and transthoracic echocardiography were performed. Read More

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http://dx.doi.org/10.1007/s12012-018-9481-zDOI Listing
September 2018

Protective Effects of a Novel Agonist of Galanin Receptors Against Doxorubicin-Induced Cardiotoxicity in Rats.

Cardiovasc Toxicol 2018 Sep 20. Epub 2018 Sep 20.

Laboratory for Myocardial Metabolism, National Medical Research Center for Cardiology, 3rd Cherepkovskaya Str., 15A, Moscow, Russian Federation, 121552.

The clinical use of antineoplastic agent doxorubicin (DOX) is limited due to its cardiotoxic action. [βAla14, His15]-galanine (2-15) (G) is a novel synthetic agonist of galanin receptors GalR1-3 having cardioprotective properties in animal models in vivo. The aim of the present study was to explore effects of G on DOX-induced cardiotoxicity. Read More

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http://dx.doi.org/10.1007/s12012-018-9483-xDOI Listing
September 2018
10 Reads

Ivabradine Aggravates the Proarrhythmic Risk in Experimental Models of Long QT Syndrome.

Cardiovasc Toxicol 2018 Sep 20. Epub 2018 Sep 20.

Division of Electrophysiology, Department of Cardiovascular Medicine, University of Münster, Münster, Germany.

Ivabradine has recently been demonstrated to have antiarrhythmic properties in atrial fibrillation. The aim of the present study was to assess the electrophysiologic profile of ivabradine in an experimental whole-heart model of long-QT-syndrome. In 12 isolated rabbit hearts long-QT-2-syndrome (LQT2) was simulated by infusion of D,L-sotalol (100 µM). Read More

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http://link.springer.com/10.1007/s12012-018-9482-y
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http://dx.doi.org/10.1007/s12012-018-9482-yDOI Listing
September 2018
8 Reads

Severe Cardiomyopathy Due to Arthroprosthetic Cobaltism: Report of Two Cases with Different Outcomes.

Cardiovasc Toxicol 2018 Aug 24. Epub 2018 Aug 24.

Department of Cardiology, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.

Cobalt-induced cardiomyopathy is a well-known but uncommon disease, and the physician must maintain a high index of suspicion in order to make a timely diagnosis. We report two patients with cobalt-induced cardiomyopathy. Both patients developed progressively worsening symptoms of cobalt toxicity following revision of a fractured ceramic-on-ceramic total hip replacement to a metal-on-polyethylene bearing. Read More

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http://link.springer.com/10.1007/s12012-018-9480-0
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http://dx.doi.org/10.1007/s12012-018-9480-0DOI Listing
August 2018
21 Reads

Anti-fibrotic Actions of Roselle Extract in Rat Model of Myocardial Infarction.

Cardiovasc Toxicol 2018 Aug 20. Epub 2018 Aug 20.

Biomedical Science, School of Diagnostic Sciences & Applied Health, Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300, Kuala Lumpur, Malaysia.

Heart failure-associated morbidity and mortality is largely attributable to extensive and unregulated cardiac remodelling. Roselle (Hibiscus sabdariffa) calyces are enriched with natural polyphenols known for antioxidant and anti-hypertensive effects, yet its effects on early cardiac remodelling in post myocardial infarction (MI) setting are still unclear. Thus, the aim of this study was to investigate the actions of roselle extract on cardiac remodelling in rat model of MI. Read More

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http://link.springer.com/10.1007/s12012-018-9478-7
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http://dx.doi.org/10.1007/s12012-018-9478-7DOI Listing
August 2018
14 Reads

Refractory Arrhythmias in a Young Patient Poisoned by Imipramine.

Cardiovasc Toxicol 2018 Aug 13. Epub 2018 Aug 13.

Medical Toxicology and Drug Abuse Research Center (MTDRC), Birjand University of Medical Sciences, Birjand, Iran.

Tricyclic antidepressants are used to treat a variety of mental disorders, and are considered a common cause of fatal drug poisoning. This study reports a young woman with no history of cardiac diseases who presented to the emergency department with heart palpitation, weakness, and lethargy. After a short period of time, she became unconscious and experienced hypotension and refractory arrhythmia, finally being diagnosed with imipramine poisoning. Read More

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http://link.springer.com/10.1007/s12012-018-9477-8
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http://dx.doi.org/10.1007/s12012-018-9477-8DOI Listing
August 2018
7 Reads

Correction to: Clopidogrel Pharmacogenetics in Iranian Patients Undergoing Percutaneous Coronary Intervention.

Cardiovasc Toxicol 2018 Oct;18(5):492

Medical Genetics Laboratory, Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Valiasr Street, Niyaesh Intersection, Tehran, 1995614331, Iran.

The original version of this article unfortunately contained a typo in the co-author name. Read More

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http://dx.doi.org/10.1007/s12012-018-9475-xDOI Listing
October 2018
2 Reads

Myocardial Injury from Tranylcypromine-Induced Hypertensive Crisis Secondary to Excessive Tyramine Intake.

Cardiovasc Toxicol 2018 Dec;18(6):583-586

Department of Emergency Medicine, Nepean Hospital, Kingswood, NSW, 2747, Australia.

Monoamine oxidase inhibitors (MAOIs) are known to cause hypertensive crisis when combined with intake of tyramine, classically found in cheese. We present a case of MAOI-induced hypertensive crisis leading to significant troponin release after soft cheese intake. A 51-year-old lady presented with left-sided chest pain, palpitations and headache in the context of significant hypertension after eating soft cheese. Read More

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http://dx.doi.org/10.1007/s12012-018-9476-9DOI Listing
December 2018
1 Read

Electrocardiographic Findings in Mortalities Due to Pure Methadone Toxicity.

Cardiovasc Toxicol 2018 Jul 17. Epub 2018 Jul 17.

Department of Clinical Toxicology, School of Medicine, Shahid Beheshti University of Medical Sciences, Arabi Ave, Daneshjoo Blvd, Velenjak, 19839-63113, Tehran, Islamic Republic of Iran.

We aimed to evaluate electrocardiographic (ECG) abnormalities in mortalities due to pure methadone toxicity in ICU patients since methadone-related mortality may be due to cardiac complications even in acute toxicities. In a retrospective single-center study, files of all patients who had died with confirmed diagnosis of pure methadone toxicity between 2011 and 2016 were evaluated. Autopsy was performed in all cases. Read More

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http://dx.doi.org/10.1007/s12012-018-9474-yDOI Listing
July 2018
9 Reads

Predictive Role of the Cervical Sympathetic Trunk Ischemia on Lower Heart Rates in an Experimentally Induced Stenoocclusive Carotid Artery Model by Bilateral Common Carotid Artery Ligation.

Cardiovasc Toxicol 2018 Jul 10. Epub 2018 Jul 10.

Department of Radiology, Medical Faculty, Ataturk University, Erzurum, Turkey.

Bilateral common carotid artery ligation (BCCAL) leads to acute craniocervicocerebral ischemia, retrograde blood flow, increased blood pressure, and significant hemodynamic and histomorphological changes at the posterior cerebral vasculature. We examined the potential relationship between denervation injury following BCCAL-induced cervical sympathetic trunk (CST) ischemia and heart rate after permanent BCCAL. Rabbits (n = 25) were randomly divided into three groups: an unoperated control group (GI, n = 6); a sham-operated control group (GII, n = 6), and an experimental group subjected to BCCAL (GIII, n = 13); and then followed for one month. Read More

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http://dx.doi.org/10.1007/s12012-018-9473-zDOI Listing
July 2018
6 Reads

Long-Term IL-2 Incubation-Induced L-type Calcium Channels Activation in Rat Ventricle Cardiomyocytes.

Cardiovasc Toxicol 2018 Jul 10. Epub 2018 Jul 10.

Department of Fundamental and Applied Physiology, Russian National Research Medical University, Ostrovitjanova 1, Moscow, 117997, Russia.

The following study examined the impact of IL-2 on Ca channel activity in the event of several hours' incubation in IL-2. The right ventricle free wall for action potential measurements was isolated and perfused with Tyrode solution. The whole-cell voltage clamp experiments were performed on enzymatically isolated single cardiomyocytes. Read More

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http://dx.doi.org/10.1007/s12012-018-9472-0DOI Listing
July 2018
11 Reads

Increased Plasma Nitrite and von Willebrand Factor Indicates Early Diagnosis of Vascular Diseases in Chemotherapy Treated Cancer Patients.

Cardiovasc Toxicol 2018 Jul 5. Epub 2018 Jul 5.

Department of Biotechnology, Anna University, Chennai, India.

Chemotherapy induced cardiotoxicity leads to development of hypertension, conduction abnormalities, and congestive heart failure. However, there is no simple test to detect and assess cardiovascular risk in a chemotherapy treated cancer patient. The aim of the present study on cancer patients treated with (n = 66) and without (n = 66) chemotherapy is to identify indicators from plasma for vascular injury. Read More

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http://link.springer.com/10.1007/s12012-018-9471-1
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http://dx.doi.org/10.1007/s12012-018-9471-1DOI Listing
July 2018
5 Reads

Poly(ADP-ribose) Polymerase (PARP) and PARP Inhibitors: Mechanisms of Action and Role in Cardiovascular Disorders.

Cardiovasc Toxicol 2018 Dec;18(6):493-506

James A. Haley Veteran's Hospital and The University of South Florida College of Public Health, 13000 Bruce B. Downs Blvd, Tampa, FL, 90012, USA.

Poly(ADP-ribosyl)ation is an immediate cellular repair response to DNA damage and is catalyzed primarily by poly(ADP-ribose)polymerase-1 (PARP1), which is the most abundant of the 18 different PARP isoforms and accounts for more than 90% of the catalytic activity of PARP in the cell nucleus. Upon detection of a DNA strand break, PARP1 binds to the DNA, cleaves nicotinamide adenine dinucleotide between nicotinamide and ribose and then modifies the DNA nuclear acceptor proteins by formation of a bond between the protein and the ADP-ribose residue. This generates ribosyl-ribosyl linkages that act as a signal for other DNA-repairing enzymes and DNA base repair. Read More

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http://dx.doi.org/10.1007/s12012-018-9462-2DOI Listing
December 2018
7 Reads

Beneficial Effect of Silymarin in Pressure Overload Induced Experimental Cardiac Hypertrophy.

Cardiovasc Toxicol 2018 Jul 2. Epub 2018 Jul 2.

Institute of Pharmacy, Nirma University, Sarkhej-Gandhinagar Highway, Ahmedabad, Gujarat, 382 481, India.

The present investigation was undertaken to study the effect of silymarin on cardiac hypertrophy induced by partial abdominal aortic constriction (PAAC) in Wistar rats. Silymarin was administered for 9 weeks at the end of which we evaluated hypertrophic, hemodynamic, non-specific cardiac markers, oxidative stress parameters, and determined mitochondrial DNA concentration. Hypertrophic control animals exhibited cardiac hypertrophy, altered hemodynamics, oxidative stress, and decreased mitochondrial DNA (mtDNA) concentration. Read More

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http://dx.doi.org/10.1007/s12012-018-9470-2DOI Listing
July 2018
4 Reads

Myocyte-Damaging Effects and Binding Kinetics of Boronic Acid and Epoxyketone Proteasomal-Targeted Drugs.

Cardiovasc Toxicol 2018 Dec;18(6):557-568

College of Pharmacy, Apotex Centre, University of Manitoba, 750 McDermot Avenue, Winnipeg, MB, R3E 0T5, Canada.

The proteasome inhibitors bortezomib, carfilzomib, and ixazomib, which are used in the treatment of multiple myeloma have greatly improved response rates. Several other proteasome inhibitors, including delanzomib and oprozomib, are in clinical trials. Carfilzomib and oprozomib are epoxyketones that form an irreversible bond with the 20S proteasome, whereas bortezomib, ixazomib, and delanzomib are boronic acids that form slowly reversible adducts. Read More

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http://dx.doi.org/10.1007/s12012-018-9468-9DOI Listing
December 2018
2 Reads

Complete Atrioventricular Block in an Elderly Patient Treated with Low-Dose Lacosamide.

Cardiovasc Toxicol 2018 Dec;18(6):579-582

Geriatrics Department, Leopold Bellan Hospital, 185 C Rue Raymond Losserand, Paris, France.

Lacosamide, one of the last antiepileptic drugs marketed, can cause extension of PR interval. Precautions are recommended when used in elderly and with other drugs extending PR interval. Cases of severe third-degree atrioventricular block have been reported only in post-marketing case reports when used at high-doses and remain rare. Read More

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http://dx.doi.org/10.1007/s12012-018-9467-xDOI Listing
December 2018
4 Reads

Inhalation of Simulated Smog Atmospheres Affects Cardiac Function in Mice.

Cardiovasc Toxicol 2018 Dec;18(6):569-578

Environmental Public Health Division, National Health and Environmental Effects Research Laboratory, US Environmental Protection Agency, 109 TW. Alexander Dr., Research Triangle Park, NC, 27711, USA.

The health effects of individual criteria air pollutants have been well investigated. However, little is known about the health effects of air pollutant mixtures that more realistically represent environmental exposures. The present study was designed to evaluate the cardiac effects of inhaled simulated smog atmospheres (SA) generated from the photochemistry of either gasoline and isoprene (SA-G) or isoprene (SA-Is) in mice. Read More

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http://dx.doi.org/10.1007/s12012-018-9469-8DOI Listing
December 2018
1 Read

The Effects of Lipid Emulsion, Magnesium Sulphate and Metoprolol in Amitriptyline-Induced Cardiovascular Toxicity in Rats.

Cardiovasc Toxicol 2018 Jun 5. Epub 2018 Jun 5.

Department of Emergency Medicine, Health Science University İzmir Bozyaka Research and Training Hospital, Izmir, Turkey.

The aim of this study was to evaluate the effects of metoprolol, lipid emulsion and MgSO which can be recommended for prevention of long QT that is one of the lethal consequences of amitriptyline intoxication. Thirty Sprague-Dawley male rats were included. Five groups respectively received the following: saline intraperitoneally (i. Read More

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http://dx.doi.org/10.1007/s12012-018-9466-yDOI Listing
June 2018
3 Reads

Effects of S-Nitrosoglutathione on Electrophysiological Manifestations of Mechanoelectric Feedback.

Cardiovasc Toxicol 2018 Dec;18(6):520-529

Department of Medicine, Universitat de València "Estudi General", Valencia, Spain.

Electromechanical coupling studies have described the intervention of nitric oxide and S-nitrosylation processes in Ca release induced by stretch, with heterogeneous findings. On the other hand, ion channel function activated by stretch is influenced by nitric oxide, and concentration-dependent biphasic effects upon several cellular functions have been described. The present study uses isolated and perfused rabbit hearts to investigate the changes in mechanoelectric feedback produced by two different concentrations of the nitric oxide carrier S-nitrosoglutathione. Read More

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http://link.springer.com/10.1007/s12012-018-9463-1
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http://dx.doi.org/10.1007/s12012-018-9463-1DOI Listing
December 2018
6 Reads

Application of a Simple Quantitative Assessment of Atherosclerotic Lesions in Freshly Isolated Aortas from Rabbits.

Cardiovasc Toxicol 2018 Dec;18(6):537-546

Regenerative Medicine Research Center, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, People's Republic of China.

Rabbits are widely used for the study of atherosclerosis; however, the lack of a unified and quantitative analysis of atheroma limits data interpretation and comparisons between laboratories. In this study, we applied a simple quantitative method, referred to as the oil red O (ORO) dye-eluting method, for analysis of atherosclerotic plaques in freshly isolated aortas. It employs ORO staining of the plaques followed by elution of the dye that is subjected to quantitative measurement. Read More

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http://dx.doi.org/10.1007/s12012-018-9465-zDOI Listing
December 2018
8 Reads

Analysis of Safety Margin of Lithium Carbonate Against Cardiovascular Adverse Events Assessed in the Halothane-Anesthetized Dogs.

Cardiovasc Toxicol 2018 Dec;18(6):530-536

Department of Pharmacology, Toho University Graduate School of Medicine, 5-21-16 Omori-nishi, Ota-ku, Tokyo, 143-8540, Japan.

Lithium is one of the classical drugs that have been widely used for treating bipolar disorder. However, several cardiac side effects including sick sinus syndrome, bundle branch block, ventricular tachycardia/fibrillation, non-specific T-wave abnormalities in addition to Brugada-type electrocardiographic changes have been noticed in patients who were given antidepressant, anticonvulsant, and/or antipsychotic drugs besides lithium. In this study, we assessed cardiohemodynamic and electrophysiological effects of lithium carbonate by itself to begin to analyze onset mechanisms of its cardiovascular side effects. Read More

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http://dx.doi.org/10.1007/s12012-018-9464-0DOI Listing
December 2018
3 Reads

A Chemosensitizer Drug: Disulfiram Prevents Doxorubicin-Induced Cardiac Dysfunction and Oxidative Stress in Rats.

Cardiovasc Toxicol 2018 Oct;18(5):459-470

Department of Pharmacology, R. C. Patel Institute of Pharmaceutical Education and Research, Shirpur-Dist. Dhule, Maharashtra, 425405, India.

In the present study, the preventive effects of orally administered disulfiram (DS) against the doxorubicin (DOX)-induced cardiotoxicity were investigated in rats. DS was orally administered for 7 days at doses of 2, 10, and 50 mg/kg/day. DOX (30 mg/kg) was intraperitoneally administered on the 5th day of the initiation of DS treatment. Read More

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http://dx.doi.org/10.1007/s12012-018-9458-yDOI Listing
October 2018
5 Reads
1 Citation
2.060 Impact Factor

Clopidogrel Pharmacogenetics in Iranian Patients Undergoing Percutaneous Coronary Intervention.

Cardiovasc Toxicol 2018 Oct;18(5):482-491

Medical Genetics Laboratory, Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Valiasr Street, Niyaesh Intersection, Tehran, 1995614331, Iran.

Clopidogrel is used in patients with coronary syndromes and at risk of thrombotic events or receiving percutaneous coronary intervention (PCI) for reducing heart attack and stroke. Here we present genotype and phenotype study of Iranian patients undergoing PCI treated with clopidogrel during a 6-month period of follow-up; common variants of CYP2C19, CYP3A5, CYP3A4, and ABCB1 genes were determined as well as the patients' cardiovascular outcomes to find out the effect of these variants individually and in combination. 388 individuals receiving PCI were enrolled in this study. Read More

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http://dx.doi.org/10.1007/s12012-018-9459-xDOI Listing
October 2018
4 Reads

The Acute Effects of Age and Particulate Matter Exposure on Heart Rate and Heart Rate Variability in Mice.

Cardiovasc Toxicol 2018 Dec;18(6):507-519

Department of Environmental Health and Engineering, Bloomberg School of Public Health, Johns Hopkins University, 615 N. Wolfe St., Baltimore, MD, 21205, USA.

Exposure to ambient particulate matter (PM) is associated with increased cardiac morbidity and mortality with the elderly considered to be the most susceptible. The purpose of this study was to determine if exposure to PM would cause a greater impact on heart regulation in older DBA/2 (D2) male mice as determined by changes in heart rate (HR) and heart rate variability (HRV). D2 mice at the ages of 4, 12, and 19 months were instilled with 100 µg of PM or saline by aspiration. Read More

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http://dx.doi.org/10.1007/s12012-018-9461-3DOI Listing
December 2018
2 Reads

Catalpol Promotes the Survival and VEGF Secretion of Bone Marrow-Derived Stem Cells and Their Role in Myocardial Repair After Myocardial Infarction in Rats.

Cardiovasc Toxicol 2018 May 11. Epub 2018 May 11.

Department of Cardiology, Shengjing Hospital of China Medical University, 36 Sanhao Street, Shenyang, 110004, Liaoning, People's Republic of China.

Bone mesenchymal stem cells (BMSCs) transplantation has been recognized as an effective method for the treatment of myocardial infarction (MI). However, its efficacy is always restricted by the low survival of transplanted BMSCs in the ischemic myocardium. The aim of this study was to investigate the effect of catalpol pre-treatment on the survival and vascular endothelial growth factor (VEGF) secretion of BMSCs under oxygen glucose deprivation (OGD) condition and their role in myocardial repair in a rat model of MI. Read More

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http://dx.doi.org/10.1007/s12012-018-9460-4DOI Listing
May 2018
1 Read

Serum miR-30c Level Predicted Cardiotoxicity in Non-small Cell Lung Cancer Patients Treated with Bevacizumab.

Cardiovasc Toxicol 2018 06;18(3):284-289

Department of Thoracic Surgery, TianJin Chest Hospital, 261 Taierzhuang South Rd., Tianjin, 300222, People's Republic of China.

Cardiotoxicity is a common adverse effect induced by drug chemotherapy. miR-30c has been reported to be involved in the progress of heart diseases. In the present study, miR-30c was used to predict the cardiotoxicity in non-small cell lung cancer (NSCLC) patients treated with bevacizumab chemotherapy. Read More

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http://dx.doi.org/10.1007/s12012-018-9457-zDOI Listing
June 2018
1 Read

On the Efficacy of Cardio-Pulmonary Resuscitation and Epinephrine Following Cyanide- and HS Intoxication-Induced Cardiac Asystole.

Cardiovasc Toxicol 2018 Oct;18(5):436-449

Division of Pulmonary and Critical Care Medicine, Department of Medicine, College of Medicine, Pennsylvania State University, 500 University Drive, H041, Hershey, PA, 17033, USA.

This study was aimed at determining the efficacy of epinephrine, followed by chest compressions, in producing a return of spontaneous circulation (ROSC) during cyanide (CN)- or hydrogen sulfide (HS)-induced toxic cardiac pulseless electrical activity (PEA) in the rat. Thirty-nine anesthetized rats were exposed to either intravenous KCN (n = 27) or HS solutions (n = 12), at a rate that led to a PEA within less than 10 min. In the group intoxicated by CN, 20 rats were mechanically ventilated and received either epinephrine (0. Read More

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http://dx.doi.org/10.1007/s12012-018-9454-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6126935PMC
October 2018
5 Reads

Inhibition of MicroRNA-23 Contributes to the Isoflurane-Mediated Cardioprotection Against Oxidative Stress.

Cardiovasc Toxicol 2018 Oct;18(5):450-458

Department of Anesthesiology, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, China.

Isoflurane is one of the most frequently used volatile anesthetics in clinical practice for inhalational anesthesia. It is widely studied that isoflurane mediates cardioprotection during multiple pathological processes. However, the precise mechanisms have not been fully elucidated. Read More

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http://dx.doi.org/10.1007/s12012-018-9455-1DOI Listing
October 2018
4 Reads

Cardiotoxicity in Hematological Diseases: Are the Tyrosine Kinase Inhibitors Imatinib and Nilotinib Safe?

Cardiovasc Toxicol 2018 Oct;18(5):431-435

Cardiology Department, Faculty of Medicine, Santa Maria University Hospital (CHLN), Lisbon Academic Medical Centre and Cardiovascular Centre of the University of Lisbon, Av. Prof. Egas Moniz, 1649-035, Lisbon, Portugal.

Chemotherapy-induced cardiotoxicity is a growing concern. The cardiotoxic impact of new drugs such as tyrosine kinase inhibitors is unknown, especially the ones used for chronic myeloid leukemia. We aim to evaluate nilotinib- and imatinib-induced cardiotoxicity. Read More

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http://dx.doi.org/10.1007/s12012-018-9453-3DOI Listing
October 2018
3 Reads
2.060 Impact Factor

6-Gingerol Ameliorates Behavioral Changes and Atherosclerotic Lesions in ApoE Mice Exposed to Chronic Mild Stress.

Cardiovasc Toxicol 2018 Oct;18(5):420-430

First Department of Cardiology, The Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, 33 Beiling Avenue, Shenyang, 110032, People's Republic of China.

Chronic mild stress (CMS) has been demonstrated to contribute to atherosclerosis. 6-gingerol (6-Gin), a phenolic component of ginger (Zingiber officinale), has been shown to exert numerous pharmacological properties, such as anti-inflammatory and cardioprotective effects. Here we investigated the role of CMS in the development of atherosclerosis in high-fat diet (HFD)-fed ApoE mice and evaluated the potential therapeutic effects of 6-Gin. Read More

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http://dx.doi.org/10.1007/s12012-018-9452-4DOI Listing
October 2018
18 Reads

Methylene Blue Counteracts HS-Induced Cardiac Ion Channel Dysfunction and ATP Reduction.

Cardiovasc Toxicol 2018 Oct;18(5):407-419

Division of Pulmonary and Critical Care Medicine, Department of Medicine, Pennsylvania State University College of Medicine, Hershey, PA, 17033, USA.

We have previously demonstrated that methylene blue (MB) counteracts the effects of hydrogen sulfide (HS) cardiotoxicity by improving cardiomyocyte contractility and intracellular Ca homeostasis disrupted by HS poisoning. In vivo, MB restores cardiac contractility severely depressed by sulfide and protects against arrhythmias, ranging from bundle branch block to ventricular tachycardia or fibrillation. To dissect the cellular mechanisms by which MB reduces arrhythmogenesis and improves bioenergetics in myocytes intoxicated with HS, we evaluated the effects of HS on resting membrane potential (E), action potential (AP), Na/Ca exchange current (I), depolarization-activated K currents and ATP levels in adult mouse cardiac myocytes and determined whether MB could counteract the toxic effects of HS on myocyte electrophysiology and ATP. Read More

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http://dx.doi.org/10.1007/s12012-018-9451-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6126975PMC
October 2018
7 Reads

Evaluation of the Effectiveness of Sugammadex for Digoxin Intoxication: An Experimental Study.

Cardiovasc Toxicol 2018 Oct;18(5):400-406

Department of Anesthesiology and Reanimation, School of Medicine, Dokuz Eylül University, İzmir, Turkey.

Previous studies have shown that cyclodextrin group medicines bind to various drugs. The hypothesis of our study is to determine whether sugammadex could bind to digoxin and delay the cardiovascular toxicity of that drug. Twenty-eight sedated Wistar rats were infused with digoxin at 3 mg/h (0. Read More

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http://dx.doi.org/10.1007/s12012-018-9450-6DOI Listing
October 2018
4 Reads
2.060 Impact Factor

Catechin Attenuates Coronary Heart Disease in a Rat Model by Inhibiting Inflammation.

Cardiovasc Toxicol 2018 Oct;18(5):393-399

Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing, 210029, Jiangsu, China.

Accumulating evidence has established that systemic inflammation is an important pathophysiologic factor of coronary heart disease (CHD). In this study, we investigated whether catechin exerts anti-inflammatory function in CHD rats. CHD model of rats was established by high-fat diet feeding and pituitrin injection. Read More

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http://dx.doi.org/10.1007/s12012-018-9449-zDOI Listing
October 2018
4 Reads