711 results match your criteria Cardiovascular toxicology[Journal]


Toxic Effects of Particulate Matter Derived from Dust Samples Near the Dzhidinski Ore Processing Mill, Eastern Siberia, Russia.

Cardiovasc Toxicol 2019 Apr 8. Epub 2019 Apr 8.

Department of Pharmaceutical Sciences, University of New Mexico-Health Sciences Center, MSC09 5360, Albuquerque, NM, 87131, USA.

Ambient particulate matter (PM) is associated with increased mortality and morbidity, an effect influenced by the metal components of the PM. We characterized five sediment samples obtained near a tungsten-molybdenum ore-processing complex in Zakamensk, Russia for elemental composition and PM toxicity with regard to pulmonary, vascular, and neurological outcomes. Elemental and trace metals analysis of complete sediment and PM (the respirable fraction, < 10 µm mass mean aerodynamic diameter) were performed using inductively coupled plasma optical emission spectrometry (ICP-OES) and mass spectrometry (ICP-MS). Read More

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http://dx.doi.org/10.1007/s12012-019-09507-yDOI Listing
April 2019
1 Read

Acute Effects of Electronic Cigarette Inhalation on the Vasculature and the Conducting Airways.

Cardiovasc Toxicol 2019 Apr 8. Epub 2019 Apr 8.

Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden.

The use of electronic cigarettes has increased exponentially since its introduction onto the global market in 2006. However, short- and long-term health effects remain largely unknown due to the novelty of this product. The present study examines the acute effects of e-cigarette aerosol inhalation, with and without nicotine, on vascular and pulmonary function in healthy volunteers. Read More

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http://dx.doi.org/10.1007/s12012-019-09516-xDOI Listing
April 2019
2 Reads

Combustion Particle-Induced Changes in Calcium Homeostasis: A Contributing Factor to Vascular Disease?

Cardiovasc Toxicol 2019 Apr 6. Epub 2019 Apr 6.

Department of Air Pollution and Noise, Division of Infection Control, Environment and Health, Norwegian Institute of Public Health, PO Box 4404, Nydalen, 0403, Oslo, Norway.

Air pollution is the leading environmental risk factor for disease and premature death in the world. This is mainly due to exposure to urban air particle matter (PM), in particular, fine and ultrafine combustion-derived particles (CDP) from traffic-related air pollution. PM and CDP, including particles from diesel exhaust (DEP), and cigarette smoke have been linked to various cardiovascular diseases (CVDs) including atherosclerosis, but the underlying cellular mechanisms remain unclear. Read More

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http://dx.doi.org/10.1007/s12012-019-09518-9DOI Listing
April 2019
1 Read

Cardiogenic Shock Due to Aluminum Phosphide Poisoning Treated with Intra-aortic Balloon Pump: A Report of Two Cases.

Cardiovasc Toxicol 2019 Apr 4. Epub 2019 Apr 4.

Medical Toxicology and Drug Abuse Research Center (MTDRC), Birjand, 9717853577, Iran.

The mortality rate from aluminum phosphide (AlP) poisoning is as high as 70-100%, with refractory hypotension and severe metabolic acidosis being the two most common presentations in this poisoning. As this poisoning has no specific antidote, treatments revolve around supportive care. Cardiogenic shock created by toxic myocarditis is considered the main cause of mortality in these patients. Read More

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http://dx.doi.org/10.1007/s12012-019-09513-0DOI Listing
April 2019
4 Reads

Bupivacaine Toxicity Increases Transmural Dispersion of Repolarization, Developing of a Brugada-like Pattern and Ventricular Arrhythmias, Which is Reversed by Lipid Emulsion Administration. Study in an Experimental Porcine Model.

Cardiovasc Toxicol 2019 Apr 3. Epub 2019 Apr 3.

CEU San Pablo University, Madrid, Spain.

Unintentional administration of bupivacaine may be associated with electrocardiogram changes that promote the development cardiac arrhythmias. Ventricular repolarization markers (corrected QT, QT dispersion, Tpeak-Tend and Tpeak-Tend dispersion) are useful to predict cardiac arrhythmias. We aim to investigate the effects of bupivacaine on the transmural dispersion of repolarization and their reversion following intravenous lipid emulsion (ILE) administration. Read More

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http://dx.doi.org/10.1007/s12012-019-09515-yDOI Listing
April 2019
1 Read

High Intensity Interval Training Ameliorates Mitochondrial Dysfunction in the Left Ventricle of Mice with Type 2 Diabetes.

Cardiovasc Toxicol 2019 Mar 29. Epub 2019 Mar 29.

Department of Circulation and Medical Imaging, Faculty of Medicine and Health Science, K.G. Jebsen Centre of Exercise in Medicine, Norwegian University of Science and Technology, Postboks 8905, 7491, Trondheim, Norway.

Both human and animal studies have shown mitochondrial and contractile dysfunction in hearts of type 2 diabetes mellitus (T2DM). Exercise training has shown positive effects on cardiac function, but its effect on the mitochondria have been insufficiently explored. The aim of this study was to assess the effect of exercise training on mitochondrial function in T2DM hearts. Read More

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http://dx.doi.org/10.1007/s12012-019-09514-zDOI Listing
March 2019
1 Read

Acute and Subacute Effects of Low Versus High Doses of Standardized Panax ginseng Extract on the Heart: An Experimental Study.

Cardiovasc Toxicol 2019 Mar 21. Epub 2019 Mar 21.

Department of Medical Pharmacology, Faculty of Medicine, Inonu University, Malatya, Turkey.

Panax ginseng is commonly used in Chinese medicine and Western herbal preparations. However, it has also been recently noted to be associated with some cardiac pathologies-including cardiogenic shock due to acute anterior myocardial infarction, trans-ischemic attack, and stent thrombosis. This study was aimed to elucidate acute and subacute effects of the low and high doses of standardized Panax ginseng extract (sPGe) on cardiac functions. Read More

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http://link.springer.com/10.1007/s12012-019-09512-1
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http://dx.doi.org/10.1007/s12012-019-09512-1DOI Listing
March 2019
89 Reads
2.060 Impact Factor

Micheliolide Protects Against Doxorubicin-Induced Cardiotoxicity in Mice by Regulating PI3K/Akt/NF-kB Signaling Pathway.

Cardiovasc Toxicol 2019 Mar 5. Epub 2019 Mar 5.

Department of Biochemistry, Faculty of Medicine, Tabriz University of Medical Sciences, Golgasht Avenue, Tabriz, 57191-58875, Iran.

Micheliolide (MCL) is a naturally derived anti-inflammatory agent. In the present investigation, we examined the protective potential of MCL against doxorubicin (DOX)-induced cardiotoxicity in mice. Mice were injected with a single 15-mg/kg intraperitoneal dose of DOX at day 1 and the study groups received daily 12. Read More

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http://dx.doi.org/10.1007/s12012-019-09511-2DOI Listing
March 2019
1 Read
2.060 Impact Factor

SSeCKS/Gravin/AKAP12 Inhibits PKCζ-Mediated Reduction of ERK5 Transactivation to Prevent Endotoxin-Induced Vascular dysfunction.

Cardiovasc Toxicol 2019 Feb 25. Epub 2019 Feb 25.

Department of Cardiovascular Surgery, Xijing Hospital, Air Force Military Medical University (Fourth Military Medical University), Xi'an, 710032, China.

SSeCKS/Gravin/AKAP12 is a protein kinase C (PKC) substrate that inhibits the activity of PKC through binding with it. SSeCKS is expressed in vascular endothelial cells (ECs). The atypical PKC isoform ζ (PKCζ) is a pathologic mediator of endothelial dysfunction. Read More

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http://dx.doi.org/10.1007/s12012-018-09502-9DOI Listing
February 2019

Characterization of microminipig as a laboratory animal for safety pharmacology study by analyzing fluvoxamine-induced cardiovascular and dermatological adverse reactions.

Cardiovasc Toxicol 2019 Feb 8. Epub 2019 Feb 8.

Department of Pharmacology, Toho University Graduate School of Medicine, 5-21-16 Omori-nishi, Ota-ku, Tokyo, 143-8540, Japan.

Fluvoxamine is a selective serotonin-reuptake inhibitor, of which IC values for serotonin- and noradrenaline-uptake process were reported to be 3.8 and 620 nmol/L, respectively, also known to directly inhibit cardiac Na, Ca, and K channels. We characterized microminipig as a laboratory animal by analyzing fluvoxamine-induced cardiovascular and dermatological responses under halothane anesthesia. Read More

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http://dx.doi.org/10.1007/s12012-019-09509-wDOI Listing
February 2019
1 Read

Effect of Gestational Age on Maternofetal Vascular Function Following Single Maternal Engineered Nanoparticle Exposure.

Cardiovasc Toxicol 2019 Feb 7. Epub 2019 Feb 7.

Environmental and Occupational Health Sciences Institute, 170 Frelinghuysen Rd, Piscataway, NJ, 08854, USA.

Normal pregnancy outcome is accomplished, in part, by rapid and expansive physiological adaptations to the systemic circulation, the extent of which is specific to gestational day (GD) and anatomical location. Pregnancy-related hemodynamic changes in uterine placental blood flow stimulate compensatory vascular signaling and remodeling that begins early and continues throughout gestation. Exposure of the maternal environment to engineered nanomaterials (ENM) during pregnancy has been shown to impact health of the dam, fetus, and adult offspring; however, the consequences of specific temporal (gestational age) and spatial (vascular location) considerations are largely undetermined. Read More

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http://dx.doi.org/10.1007/s12012-019-09505-0DOI Listing
February 2019

Linoleic Acid Metabolite DiHOME Decreases Post-ischemic Cardiac Recovery in Murine Hearts.

Cardiovasc Toxicol 2019 Feb 6. Epub 2019 Feb 6.

Experimental and Clinical Research Center, 16341, Berlin, Germany.

Cardiac ischemia/reperfusion injury is associated with the formation and action of lipid mediators derived from polyunsaturated fatty acids. Among them, linoleic acid (LA) is metabolized to epoxyoctadecanoic acids (EpOMEs) by cytochrome P450 (CYP) epoxygenases and further to dihydroxyoctadecanoic acids (DiHOMEs) by soluble epoxide hydrolase (sEH). We hypothesized that EpOMEs and/or DiHOMEs may affect cardiac post-ischemic recovery and addressed this question using isolated murine hearts in a Langendorff system. Read More

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http://dx.doi.org/10.1007/s12012-019-09508-xDOI Listing
February 2019
1 Read

Measurement of J-Tc along with QT-Interval Prolongation May Increase the Assay Sensitivity and Specificity for Predicting the Onset of Drug-Induced Torsade de Pointes: Experimental Evidences Based on Proarrhythmia Model Animals.

Cardiovasc Toxicol 2019 Feb 2. Epub 2019 Feb 2.

Department of Pharmacology, Toho University Graduate School of Medicine, 5-21-16 Omori-nishi, Ota-ku, Tokyo, 143-8540, Japan.

dl-Sotalol which can block both K channel and ß-adrenoceptor has been shown to prolong the J-Tc of electrocardiogram in beagle dogs but tended to shorten it in microminipigs, although the drug prolonged the QT interval in both animals under physiologically maintained experimental condition. In order to estimate how the changes in the J-Tc in the normal hearts would be reflected in the pathologic hearts, we compared proarrhythmic effects of dl-sotalol by using proarrhythmia models of beagle dogs and microminipigs, of which atrioventricular node had been ablated > 2 months and 8-9 weeks before, respectively (n = 4 for each species). dl-Sotalol in an oral dose of 10 mg/kg induced torsade de pointes in three out of four beagle dogs, which degenerated into ventricular fibrillation. Read More

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http://dx.doi.org/10.1007/s12012-019-09506-zDOI Listing
February 2019
6 Reads

Prenatal Alcohol Exposure Causes Adverse Cardiac Extracellular Matrix Changes and Dysfunction in Neonatal Mice.

Cardiovasc Toxicol 2019 Jan 25. Epub 2019 Jan 25.

Department of Physiology, LSU Health Sciences Center, 1901 Perdido Street, New Orleans, LA, 70112, USA.

Fetal alcohol syndrome (FAS) is the most severe condition of fetal alcohol spectrum disorders (FASD) and is associated with congenital heart defects. However, more subtle defects such as ventricular wall thinning and cardiac compliance may be overlooked in FASD. Our studies focus on the role of cardiac fibroblasts in the neonatal heart, and how they are affected by prenatal alcohol exposure (PAE). Read More

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http://dx.doi.org/10.1007/s12012-018-09503-8DOI Listing
January 2019
2 Reads

Carnitine Supplementation Attenuates Sunitinib-Induced Inhibition of AMP-Activated Protein Kinase Downstream Signals in Cardiac Tissues.

Cardiovasc Toxicol 2019 Jan 14. Epub 2019 Jan 14.

Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh, 11451, Kingdom of Saudi Arabia.

This study has been initiated to investigate whether sunitinib (SUN) alters the expression of key genes engaged in mitochondrial transport and oxidation of long chain fatty acids (LCFA), and if so, whether these alterations should be viewed as a mechanism of SUN-induced cardiotoxicity, and to explore the molecular mechanisms whereby carnitine supplementation could attenuate SUN-induced cardiotoxicity. Adult male Wister albino rats were assigned to one of the four treatment groups: Rats in group 1 received no treatment but free access to tap water for 28 days. Rats in group 2 received L-carnitine (200 mg/kg/day) in drinking water for 28 days. Read More

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http://link.springer.com/10.1007/s12012-018-9500-0
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http://dx.doi.org/10.1007/s12012-018-9500-0DOI Listing
January 2019
3 Reads

An Overview on Arsenic Trioxide-Induced Cardiotoxicity.

Cardiovasc Toxicol 2019 Apr;19(2):105-119

Agroprocessing and Natural Products Division, National Institute for Interdisciplinary Science and Technology (CSIR - NIIST), Thiruvananthapuram, Kerala, 695019, India.

Arsenic trioxide (ATO) is among the first-line chemotherapeutic drugs used in oncological practice. It has shown substantial efficacy in treating patients with relapsed or refractory acute promyelocytic leukaemia. The clinical use of ATO is hampered due to cardiotoxicity and hence many patients are precluded from receiving this highly effective treatment. Read More

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http://dx.doi.org/10.1007/s12012-018-09504-7DOI Listing
April 2019
2 Reads

Diagnostic Value of Parameters Related to White Blood Cell Counts for Troponin I Elevation in CO Poisoning.

Cardiovasc Toxicol 2019 Jan 4. Epub 2019 Jan 4.

Department of Emergency Medicine, Chonnam National University Medical School, Hak Dong 8, Donggu, Gwangju, 501-747, South Korea.

To assess myocardial injury related to acute carbon monoxide (CO) poisoning, serial troponin I is measured in patients not presenting with troponin I elevation. This retrospective study investigated whether parameters related to white blood cell (WBC) counts (total and differential WBC counts, neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio) improved predictive accuracy for troponin I elevation (> 0.04 ng/ml) in patients not presenting with evidence of myocardial injury. Read More

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http://dx.doi.org/10.1007/s12012-018-09501-wDOI Listing
January 2019
1 Read

Fulminant Vascular and Cardiac Toxicity Associated with Tyrosine Kinase Inhibitor Sorafenib.

Cardiovasc Toxicol 2018 Dec 12. Epub 2018 Dec 12.

Department of Cardiology, The University of Texas MD Anderson Cancer Center, 1400 Pressler Street, 1451, 77030, Houston, TX, USA.

The use of vascular endothelial growth factor inhibitors such as sorafenib is limited by a risk of severe cardiovascular toxicity. A 28-year-old man with acute myeloid leukemia treated with prednisone, tacrolimus, and sorafenib following stem cell transplantation presented with severe bilateral lower extremity claudication. The patient was discharged against medical advice prior to finalizing a cardiovascular evaluation, but returned 1 week later with signs suggestive of septic shock. Read More

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http://dx.doi.org/10.1007/s12012-018-9499-2DOI Listing
December 2018
1 Read
2.060 Impact Factor

Cobalt Administration Causes Reduced Contractility with Parallel Increases in TRPC6 and TRPM7 Transporter Protein Expression in Adult Rat Hearts.

Cardiovasc Toxicol 2018 Dec 6. Epub 2018 Dec 6.

Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, G4 0RE, Scotland, UK.

Exposure to circulating cobalt (Co) in patients with metal-on-metal orthopaedic hip implants has been linked to cardiotoxicity but the underlying mechanism(s) remain undefined. The aim of the current study was to examine the effects of Co on the heart in vivo and specifically on cardiac fibroblasts in vitro. Adult male rats were treated with CoCl (1 mg/kg) for either 7 days or 28 days. Read More

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http://dx.doi.org/10.1007/s12012-018-9498-3DOI Listing
December 2018
1 Read

MiR-15b-5p is Involved in Doxorubicin-Induced Cardiotoxicity via Inhibiting Bmpr1a Signal in H9c2 Cardiomyocyte.

Cardiovasc Toxicol 2018 Dec 7. Epub 2018 Dec 7.

Department of Cardiology, The Second Affiliated Hospital of Shantou University Medical College, Dongxia North Road, Shantou, 515041, Guangdong, People's Republic of China.

The wide use of anthracyclines represented by doxorubicin (DOX) has benefited cancer patients, yet the clinical application is limited due to its cardiotoxicity. Although numerous evidences have supported a role of microRNAs (miRNAs) in DOX-induced myocardial damage, the exact etiology and pathogenesis remain largely obscure. In this study, we focused on the role of miR-15b-5p in DOX-induced cardiotoxicity. Read More

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http://dx.doi.org/10.1007/s12012-018-9495-6DOI Listing
December 2018
2 Reads

Ischemic Preconditioning Efficacy Following Anabolic Steroid Usage: A Clear Difference Between Sedentary and Exercise-Trained Rat Hearts.

Cardiovasc Toxicol 2018 Dec 7. Epub 2018 Dec 7.

Department of Physiology, Faculty of Medicine, Bushehr University of Medical Sciences, Bushehr, Iran.

Previous studies show that anabolic steroids impair innate cardioprotective mechanisms. Here, we investigated the effect of supraphysiological doses of nandrolone on ischemic preconditioning (IPC) as a potent cardioprotective tool against ischemia reperfusion (IR) injury in rat hearts. Male Wistar rats in two experimental settings of sedentary and exercise-trained (60 min/day swimming, 5 days/week, for 8 weeks) were either pretreated with intramuscular injections of arachis oil (Arach, n = 16) as vehicle or nandrolone decanoate (ND, n = 8), 10 mg/kg/week, for 8 weeks. Read More

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http://dx.doi.org/10.1007/s12012-018-9497-4DOI Listing
December 2018
2 Reads
2.060 Impact Factor

Vildagliptin, an Anti-diabetic Drug of the DPP-4 Inhibitor, Induces Vasodilation via Kv Channel and SERCA Pump Activation in Aortic Smooth Muscle.

Cardiovasc Toxicol 2018 Dec 5. Epub 2018 Dec 5.

Department of Physiology, Kangwon National University School of Medicine, 1 Kangwondaehak-gil, Chuncheon, 24341, South Korea.

This study investigated vildagliptin-induced vasodilation and its related mechanisms using phenylephrine induced precontracted rabbit aortic rings. Vildagliptin induced vasodilation in a concentration-dependent manner. Pretreatment with the large-conductance Ca-activated K channel blocker paxilline, ATP-sensitive K channel blocker glibenclamide, and inwardly rectifying K channel blocker Ba did not affect the vasodilatory effects of vildagliptin. Read More

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http://link.springer.com/10.1007/s12012-018-9496-5
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http://dx.doi.org/10.1007/s12012-018-9496-5DOI Listing
December 2018
16 Reads
2.060 Impact Factor

Endothelial Cells: From Dysfunction Mechanism to Pharmacological Effect in Cardiovascular Disease.

Cardiovasc Toxicol 2019 02;19(1):13-22

Thalassemia and Hemoglobinopathy Research Center, Research Institute of Health, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Endothelial cells (ECs) are the innermost layer of blood vessels that play important roles in homeostasis and vascular function. However, recent evidence suggests that the onset of inflammation and the production of reactive oxygen species impair the function of ECs and are a main factor in the development of cardiovascular disease (CVD). In this study, we investigated the effects of inflammatory markers, oxidative stress, and treatment on ECs in CVD patients. Read More

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http://link.springer.com/10.1007/s12012-018-9493-8
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http://dx.doi.org/10.1007/s12012-018-9493-8DOI Listing
February 2019
26 Reads

Digitalis Promotes Ventricular Arrhythmias in Flecainide- and Ranolazine-Pretreated Hearts.

Cardiovasc Toxicol 2018 Dec 4. Epub 2018 Dec 4.

Department of Cardiology II - Electrophysiology, University Hospital Münster, Münster, Germany.

A post hoc analysis of the PALLAS trial suggested life-threatening interactions of digitalis and dronedarone. Thus, there is concern about an interplay between digitalis and other drugs that influence cardiac electrophysiology. We therefore investigated the interaction between digitalis and flecainide or ranolazine. Read More

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http://dx.doi.org/10.1007/s12012-018-9494-7DOI Listing
December 2018
4 Reads

Cyclosporine Metabolites' Metabolic Ratios May Be Markers of Cardiovascular Disease in Kidney Transplant Recipients Treated with Cyclosporine A-Based Immunosuppression Regimens.

Cardiovasc Toxicol 2018 Nov 23. Epub 2018 Nov 23.

Department of Immunology, Transplant Medicine and Internal Diseases, Medical University of Warsaw, 59 Nowogrodzka St, Warsaw, Poland.

Cardiovascular disease (CVD) remains one of the primary causes of death after kidney transplantation (KTX). Cyclosporine (CsA) metabolites may play a role in CVD. Metabolic ratio (MR) may be considered a measure of intra-individual differences of CsA metabolism. Read More

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http://dx.doi.org/10.1007/s12012-018-9492-9DOI Listing
November 2018
9 Reads

Nano-medicine and Vascular Endothelial Dysfunction: Options and Delivery Strategies.

Cardiovasc Toxicol 2019 02;19(1):1-12

Cardiovascular Division, Department of Pharmacology, Amity Institute of Pharmacy, Amity University, Gurugram, Haryana, 122051, India.

The endothelium is a thin innermost layer of flat cells which release various mediators including endothelin-1 (ET-1), prostanoids, von Willebrand factor (vWF) and endothelium-derived relaxing factor (EDRF; nitric oxide) to regulate vascular tone. Endothelial nitric oxide synthase (eNOS) is a key enzyme that generates nitric oxide (NO). NO maintains vascular homeostasis and cardiac functions by influencing major vascular protective properties such as anti-platelet, anti-proliferative, anti-migratory, antioxidant and anti-inflammatory action in vessels. Read More

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http://link.springer.com/10.1007/s12012-018-9491-x
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http://dx.doi.org/10.1007/s12012-018-9491-xDOI Listing
February 2019
17 Reads

Effects of Ambient Atmospheric PM, 1-Nitropyrene and 9-Nitroanthracene on DNA Damage and Oxidative Stress in Hearts of Rats.

Cardiovasc Toxicol 2019 Apr;19(2):178-190

State Key Laboratory of Environmental and Biological Analysis, Department of Chemistry, Hong Kong Baptist University, Kowloon Tong, Jiulong, Hong Kong SAR, China.

Exposure to fine particulate matter (PM) increased the risks of cardiovascular diseases. PM-bound 1-nitropyrene (1-NP) and 9-nitroanthracene (9-NA) are released from the incomplete combustion of fossil fuels and derived from polycyclic aromatic hydrocarbons (PAHs). The toxicities of 1-NP and 9-NA are mainly reflected in their carcinogenicity and mutagenicity. Read More

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http://link.springer.com/10.1007/s12012-018-9488-5
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http://dx.doi.org/10.1007/s12012-018-9488-5DOI Listing
April 2019
7 Reads

Cardiotoxicity of Pesticides: Are Africans at Risk?

Authors:
Raphael Anakwue

Cardiovasc Toxicol 2019 Apr;19(2):95-104

Department of Medicine, Department of Pharmacology/Therapeutics, Faculty of Medical Sciences, University of Nigeria, University of Nigeria Teaching Hospital, Enugu, Nigeria.

Cardiovascular disease has maintained the unenviable position as the number one cause of death in the world. It is now clear that the traditional risk factors of cardiovascular disease are driven by primary factors like globalisation, urbanisation, industrialisation and agricultural practices. Pesticide use is an integral component of modern and improved agriculture. Read More

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http://link.springer.com/10.1007/s12012-018-9486-7
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http://dx.doi.org/10.1007/s12012-018-9486-7DOI Listing
April 2019
17 Reads

Limb Blood Flow Restriction Plus Mild Aerobic Exercise Training Protects the Heart Against Isoproterenol-Induced Cardiac Injury in Old Rats: Role of GSK-3β.

Cardiovasc Toxicol 2018 Nov 7. Epub 2018 Nov 7.

Department of Physical Education, Faculty of Shahid Chamran, Kerman Branch, Technical and Vocational University (YVU), Tehran, Iran.

The present study was conducted to evaluate the effect of blood flow restriction (BFR) training on cardiac resistance to isoproterenol (ISO) induced heart injury in old rats and examined the hypothesis that BFR training may interfere with age-associated impairment of mitochondria by the inhibitory phosphorylation of GSK-3β at Ser9. Old male Wistar rats were divided into the following six groups: CTL (control), ISO (isoproterenol-treated), Sh + ISO (sham-operated plus ISO), BFR + ISO (blood flow restriction plus ISO), Sh-Ex + ISO (sham-operated subjected to exercise and ISO), and BFR-Ex + ISO (blood flow restriction along with exercise and ISO). 10 weeks of exercise training was considered. Read More

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http://link.springer.com/10.1007/s12012-018-9490-y
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http://dx.doi.org/10.1007/s12012-018-9490-yDOI Listing
November 2018
14 Reads

Airway Exposure to Modified Multi-walled Carbon Nanotubes Perturbs Cardiovascular Adenosinergic Signaling in Mice.

Cardiovasc Toxicol 2019 Apr;19(2):168-177

College of Health Professions, School of Movement and Rehabilitation Sciences, Bellarmine University, 2001 Newburg Road, Louisville, KY, 40205, USA.

The broad list of commercial applications for multi-walled carbon nanotubes (MWCNT) can be further expanded with the addition of various surface chemistry modifications. For example, standard commercial grade MWCNT (C-grade) can be carboxylated (COOH) or nitrogen-doped (N-doped) to suite specific utilities. We previously reported dose-dependent expansions of cardiac ischemia/reperfusion (I/R) injury, 24 h after intratracheal instillation of C-grade, COOH, or N-doped MWCNT in mice. Read More

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http://link.springer.com/10.1007/s12012-018-9487-6
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http://dx.doi.org/10.1007/s12012-018-9487-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6470003PMC
April 2019
4 Reads

Methoxetamine Induces Cytotoxicity in H9c2 Cells: Possible Role of p21 Protein (Cdc42/Rac)-Activated Kinase 1.

Cardiovasc Toxicol 2018 Oct 30. Epub 2018 Oct 30.

College of Pharmacy and Medical Research Center, Chungbuk National University, 194-31 Osongsaemgmyeong 1-ro, Osong-eup, Heungdeok-gu, Cheongju-si, Chungbuk, 28160, Republic of Korea.

The abuse of new psychoactive substances (NPS) is an emerging social problem. Methoxetamine, one of the NPS, was designed as an alternative to ketamine and it was considered an NPS candidate owing to its high addictive potential. However, cardiotoxicity of the phencyclidine analogue, methoxetamine, has not been extensively evaluated. Read More

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http://dx.doi.org/10.1007/s12012-018-9489-4DOI Listing
October 2018
3 Reads

Phenolic Metabolites Modulate Cardiomyocyte Beating in Response to Isoproterenol.

Cardiovasc Toxicol 2019 Apr;19(2):156-167

CEDOC, NOVA Medical School, Faculdade de Ciências Médicas, Universidade Nova de Lisboa, Campo Mártires da Pátria, 130, 1169-056, Lisboa, Portugal.

Cardiovascular disease (CVD) is a public health concern, and the third cause of death worldwide. Several epidemiological studies and experimental approaches have demonstrated that consumption of polyphenol-enriched fruits and vegetables can promote cardioprotection. Thus, diet plays a key role in CVD development and/or prevention. Read More

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http://link.springer.com/10.1007/s12012-018-9485-8
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http://dx.doi.org/10.1007/s12012-018-9485-8DOI Listing
April 2019
43 Reads

Pregnancy-Associated Plasma Protein A (PAPP-A) Concentration in Population of Healthy Young People: Interactions with Tobacco Smoke and Anti-oxidative Status.

Cardiovasc Toxicol 2019 Apr;19(2):120-128

Department of Chemistry, School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia, Katowice, Poland.

Pregnancy-associated plasma protein A (PAPP-A) is a high-molecular zinc-binding metalloproteinase that was first detected in the serum of pregnant women. It can also be detected in men and non-pregnant women. Recently, a growing interest in determining the concentration of PAPP-A as a marker of oxidative stress and atherosclerotic processes has been observed. Read More

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http://link.springer.com/10.1007/s12012-018-9479-6
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http://dx.doi.org/10.1007/s12012-018-9479-6DOI Listing
April 2019
5 Reads

Risk of Myocardial Infarction After Carbon Monoxide Poisoning: A Nationwide Population-Based Cohort Study.

Cardiovasc Toxicol 2019 Apr;19(2):147-155

Department of Environmental and Occupational Health, College of Medicine, National Cheng Kung University, 1 Daxue Road, East District, Tainan City 701, Tainan, Taiwan.

Carbon monoxide poisoning (COP) may lead to ischemic changes in organs, and heart is one of the most susceptible targets to ischemic condition. The objective of this study is to evaluate the risk of myocardial infarction following COP. Using a nationwide database of insurance claims in Taiwan, we conducted a population-based cohort study to identify COP patients diagnosed between 1999 and 2012. Read More

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http://dx.doi.org/10.1007/s12012-018-9484-9DOI Listing
April 2019
1 Read

Late Cardiac Complications of Sulfur Mustard Poisoning in 38 Iranian Veterans.

Cardiovasc Toxicol 2018 Sep 21. Epub 2018 Sep 21.

School of Medicine, Medical Toxicology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

It was aimed to investigate possible late cardiac effects of Sulfur mustard (SM) exposure in Iranian veterans. Thirty-eight veterans with late complications of SM exposure were investigated. Clinical history, physical examinations, 12 leads electrocardiography and transthoracic echocardiography were performed. Read More

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http://dx.doi.org/10.1007/s12012-018-9481-zDOI Listing
September 2018
2 Reads

Protective Effects of a Novel Agonist of Galanin Receptors Against Doxorubicin-Induced Cardiotoxicity in Rats.

Cardiovasc Toxicol 2019 Apr;19(2):136-146

Laboratory for Myocardial Metabolism, National Medical Research Center for Cardiology, 3rd Cherepkovskaya Str., 15A, Moscow, Russian Federation, 121552.

The clinical use of antineoplastic agent doxorubicin (DOX) is limited due to its cardiotoxic action. [βAla14, His15]-galanine (2-15) (G) is a novel synthetic agonist of galanin receptors GalR1-3 having cardioprotective properties in animal models in vivo. The aim of the present study was to explore effects of G on DOX-induced cardiotoxicity. Read More

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http://dx.doi.org/10.1007/s12012-018-9483-xDOI Listing
April 2019
18 Reads

Ivabradine Aggravates the Proarrhythmic Risk in Experimental Models of Long QT Syndrome.

Cardiovasc Toxicol 2019 Apr;19(2):129-135

Division of Electrophysiology, Department of Cardiovascular Medicine, University of Münster, Münster, Germany.

Ivabradine has recently been demonstrated to have antiarrhythmic properties in atrial fibrillation. The aim of the present study was to assess the electrophysiologic profile of ivabradine in an experimental whole-heart model of long-QT-syndrome. In 12 isolated rabbit hearts long-QT-2-syndrome (LQT2) was simulated by infusion of D,L-sotalol (100 µM). Read More

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http://link.springer.com/10.1007/s12012-018-9482-y
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http://dx.doi.org/10.1007/s12012-018-9482-yDOI Listing
April 2019
27 Reads

Severe Cardiomyopathy Due to Arthroprosthetic Cobaltism: Report of Two Cases with Different Outcomes.

Cardiovasc Toxicol 2019 02;19(1):82-89

Department of Cardiology, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.

Cobalt-induced cardiomyopathy is a well-known but uncommon disease, and the physician must maintain a high index of suspicion in order to make a timely diagnosis. We report two patients with cobalt-induced cardiomyopathy. Both patients developed progressively worsening symptoms of cobalt toxicity following revision of a fractured ceramic-on-ceramic total hip replacement to a metal-on-polyethylene bearing. Read More

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http://link.springer.com/10.1007/s12012-018-9480-0
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http://dx.doi.org/10.1007/s12012-018-9480-0DOI Listing
February 2019
38 Reads

Anti-fibrotic Actions of Roselle Extract in Rat Model of Myocardial Infarction.

Cardiovasc Toxicol 2019 02;19(1):72-81

Biomedical Science, School of Diagnostic Sciences & Applied Health, Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300, Kuala Lumpur, Malaysia.

Heart failure-associated morbidity and mortality is largely attributable to extensive and unregulated cardiac remodelling. Roselle (Hibiscus sabdariffa) calyces are enriched with natural polyphenols known for antioxidant and anti-hypertensive effects, yet its effects on early cardiac remodelling in post myocardial infarction (MI) setting are still unclear. Thus, the aim of this study was to investigate the actions of roselle extract on cardiac remodelling in rat model of MI. Read More

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http://link.springer.com/10.1007/s12012-018-9478-7
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http://dx.doi.org/10.1007/s12012-018-9478-7DOI Listing
February 2019
25 Reads

Refractory Arrhythmias in a Young Patient Poisoned by Imipramine.

Cardiovasc Toxicol 2019 02;19(1):90-93

Medical Toxicology and Drug Abuse Research Center (MTDRC), Birjand University of Medical Sciences, Birjand, Iran.

Tricyclic antidepressants are used to treat a variety of mental disorders, and are considered a common cause of fatal drug poisoning. This study reports a young woman with no history of cardiac diseases who presented to the emergency department with heart palpitation, weakness, and lethargy. After a short period of time, she became unconscious and experienced hypotension and refractory arrhythmia, finally being diagnosed with imipramine poisoning. Read More

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http://link.springer.com/10.1007/s12012-018-9477-8
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http://dx.doi.org/10.1007/s12012-018-9477-8DOI Listing
February 2019
10 Reads

Correction to: Clopidogrel Pharmacogenetics in Iranian Patients Undergoing Percutaneous Coronary Intervention.

Cardiovasc Toxicol 2018 10;18(5):492

Medical Genetics Laboratory, Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Valiasr Street, Niyaesh Intersection, Tehran, 1995614331, Iran.

The original version of this article unfortunately contained a typo in the co-author name. Read More

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http://dx.doi.org/10.1007/s12012-018-9475-xDOI Listing
October 2018
5 Reads

Myocardial Injury from Tranylcypromine-Induced Hypertensive Crisis Secondary to Excessive Tyramine Intake.

Cardiovasc Toxicol 2018 12;18(6):583-586

Department of Emergency Medicine, Nepean Hospital, Kingswood, NSW, 2747, Australia.

Monoamine oxidase inhibitors (MAOIs) are known to cause hypertensive crisis when combined with intake of tyramine, classically found in cheese. We present a case of MAOI-induced hypertensive crisis leading to significant troponin release after soft cheese intake. A 51-year-old lady presented with left-sided chest pain, palpitations and headache in the context of significant hypertension after eating soft cheese. Read More

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http://dx.doi.org/10.1007/s12012-018-9476-9DOI Listing
December 2018
3 Reads

Electrocardiographic Findings in Mortalities Due to Pure Methadone Toxicity.

Cardiovasc Toxicol 2019 02;19(1):62-71

Department of Clinical Toxicology, School of Medicine, Shahid Beheshti University of Medical Sciences, Arabi Ave, Daneshjoo Blvd, Velenjak, 19839-63113, Tehran, Islamic Republic of Iran.

We aimed to evaluate electrocardiographic (ECG) abnormalities in mortalities due to pure methadone toxicity in ICU patients since methadone-related mortality may be due to cardiac complications even in acute toxicities. In a retrospective single-center study, files of all patients who had died with confirmed diagnosis of pure methadone toxicity between 2011 and 2016 were evaluated. Autopsy was performed in all cases. Read More

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http://dx.doi.org/10.1007/s12012-018-9474-yDOI Listing
February 2019
20 Reads

Predictive Role of the Cervical Sympathetic Trunk Ischemia on Lower Heart Rates in an Experimentally Induced Stenoocclusive Carotid Artery Model by Bilateral Common Carotid Artery Ligation.

Cardiovasc Toxicol 2019 02;19(1):56-61

Department of Radiology, Medical Faculty, Ataturk University, Erzurum, Turkey.

Bilateral common carotid artery ligation (BCCAL) leads to acute craniocervicocerebral ischemia, retrograde blood flow, increased blood pressure, and significant hemodynamic and histomorphological changes at the posterior cerebral vasculature. We examined the potential relationship between denervation injury following BCCAL-induced cervical sympathetic trunk (CST) ischemia and heart rate after permanent BCCAL. Rabbits (n = 25) were randomly divided into three groups: an unoperated control group (GI, n = 6); a sham-operated control group (GII, n = 6), and an experimental group subjected to BCCAL (GIII, n = 13); and then followed for one month. Read More

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http://dx.doi.org/10.1007/s12012-018-9473-zDOI Listing
February 2019
9 Reads

Long-Term IL-2 Incubation-Induced L-type Calcium Channels Activation in Rat Ventricle Cardiomyocytes.

Cardiovasc Toxicol 2019 02;19(1):48-55

Department of Fundamental and Applied Physiology, Russian National Research Medical University, Ostrovitjanova 1, Moscow, 117997, Russia.

The following study examined the impact of IL-2 on Ca channel activity in the event of several hours' incubation in IL-2. The right ventricle free wall for action potential measurements was isolated and perfused with Tyrode solution. The whole-cell voltage clamp experiments were performed on enzymatically isolated single cardiomyocytes. Read More

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http://dx.doi.org/10.1007/s12012-018-9472-0DOI Listing
February 2019
24 Reads

Increased Plasma Nitrite and von Willebrand Factor Indicates Early Diagnosis of Vascular Diseases in Chemotherapy Treated Cancer Patients.

Cardiovasc Toxicol 2019 02;19(1):36-47

Department of Biotechnology, Anna University, Chennai, India.

Chemotherapy induced cardiotoxicity leads to development of hypertension, conduction abnormalities, and congestive heart failure. However, there is no simple test to detect and assess cardiovascular risk in a chemotherapy treated cancer patient. The aim of the present study on cancer patients treated with (n = 66) and without (n = 66) chemotherapy is to identify indicators from plasma for vascular injury. Read More

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http://link.springer.com/10.1007/s12012-018-9471-1
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http://dx.doi.org/10.1007/s12012-018-9471-1DOI Listing
February 2019
7 Reads

Poly(ADP-ribose) Polymerase (PARP) and PARP Inhibitors: Mechanisms of Action and Role in Cardiovascular Disorders.

Cardiovasc Toxicol 2018 12;18(6):493-506

James A. Haley Veteran's Hospital and The University of South Florida College of Public Health, 13000 Bruce B. Downs Blvd, Tampa, FL, 90012, USA.

Poly(ADP-ribosyl)ation is an immediate cellular repair response to DNA damage and is catalyzed primarily by poly(ADP-ribose)polymerase-1 (PARP1), which is the most abundant of the 18 different PARP isoforms and accounts for more than 90% of the catalytic activity of PARP in the cell nucleus. Upon detection of a DNA strand break, PARP1 binds to the DNA, cleaves nicotinamide adenine dinucleotide between nicotinamide and ribose and then modifies the DNA nuclear acceptor proteins by formation of a bond between the protein and the ADP-ribose residue. This generates ribosyl-ribosyl linkages that act as a signal for other DNA-repairing enzymes and DNA base repair. Read More

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http://dx.doi.org/10.1007/s12012-018-9462-2DOI Listing
December 2018
11 Reads

Beneficial Effect of Silymarin in Pressure Overload Induced Experimental Cardiac Hypertrophy.

Cardiovasc Toxicol 2019 02;19(1):23-35

Institute of Pharmacy, Nirma University, Sarkhej-Gandhinagar Highway, Ahmedabad, Gujarat, 382 481, India.

The present investigation was undertaken to study the effect of silymarin on cardiac hypertrophy induced by partial abdominal aortic constriction (PAAC) in Wistar rats. Silymarin was administered for 9 weeks at the end of which we evaluated hypertrophic, hemodynamic, non-specific cardiac markers, oxidative stress parameters, and determined mitochondrial DNA concentration. Hypertrophic control animals exhibited cardiac hypertrophy, altered hemodynamics, oxidative stress, and decreased mitochondrial DNA (mtDNA) concentration. Read More

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http://dx.doi.org/10.1007/s12012-018-9470-2DOI Listing
February 2019
5 Reads

Myocyte-Damaging Effects and Binding Kinetics of Boronic Acid and Epoxyketone Proteasomal-Targeted Drugs.

Cardiovasc Toxicol 2018 12;18(6):557-568

College of Pharmacy, Apotex Centre, University of Manitoba, 750 McDermot Avenue, Winnipeg, MB, R3E 0T5, Canada.

The proteasome inhibitors bortezomib, carfilzomib, and ixazomib, which are used in the treatment of multiple myeloma have greatly improved response rates. Several other proteasome inhibitors, including delanzomib and oprozomib, are in clinical trials. Carfilzomib and oprozomib are epoxyketones that form an irreversible bond with the 20S proteasome, whereas bortezomib, ixazomib, and delanzomib are boronic acids that form slowly reversible adducts. Read More

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http://dx.doi.org/10.1007/s12012-018-9468-9DOI Listing
December 2018
6 Reads

Complete Atrioventricular Block in an Elderly Patient Treated with Low-Dose Lacosamide.

Cardiovasc Toxicol 2018 12;18(6):579-582

Geriatrics Department, Leopold Bellan Hospital, 185 C Rue Raymond Losserand, Paris, France.

Lacosamide, one of the last antiepileptic drugs marketed, can cause extension of PR interval. Precautions are recommended when used in elderly and with other drugs extending PR interval. Cases of severe third-degree atrioventricular block have been reported only in post-marketing case reports when used at high-doses and remain rare. Read More

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http://dx.doi.org/10.1007/s12012-018-9467-xDOI Listing
December 2018
13 Reads