660 results match your criteria Cardiovascular toxicology[Journal]


The Effects of Lipid Emulsion, Magnesium Sulphate and Metoprolol in Amitriptyline-Induced Cardiovascular Toxicity in Rats.

Cardiovasc Toxicol 2018 Jun 5. Epub 2018 Jun 5.

Department of Emergency Medicine, Health Science University İzmir Bozyaka Research and Training Hospital, Izmir, Turkey.

The aim of this study was to evaluate the effects of metoprolol, lipid emulsion and MgSO which can be recommended for prevention of long QT that is one of the lethal consequences of amitriptyline intoxication. Thirty Sprague-Dawley male rats were included. Five groups respectively received the following: saline intraperitoneally (i. Read More

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Effects of S-Nitrosoglutathione on Electrophysiological Manifestations of Mechanoelectric Feedback.

Cardiovasc Toxicol 2018 Jun 4. Epub 2018 Jun 4.

Department of Medicine, Universitat de València "Estudi General", Valencia, Spain.

Electromechanical coupling studies have described the intervention of nitric oxide and S-nitrosylation processes in Ca release induced by stretch, with heterogeneous findings. On the other hand, ion channel function activated by stretch is influenced by nitric oxide, and concentration-dependent biphasic effects upon several cellular functions have been described. The present study uses isolated and perfused rabbit hearts to investigate the changes in mechanoelectric feedback produced by two different concentrations of the nitric oxide carrier S-nitrosoglutathione. Read More

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Application of a Simple Quantitative Assessment of Atherosclerotic Lesions in Freshly Isolated Aortas from Rabbits.

Cardiovasc Toxicol 2018 Jun 1. Epub 2018 Jun 1.

Regenerative Medicine Research Center, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, People's Republic of China.

Rabbits are widely used for the study of atherosclerosis; however, the lack of a unified and quantitative analysis of atheroma limits data interpretation and comparisons between laboratories. In this study, we applied a simple quantitative method, referred to as the oil red O (ORO) dye-eluting method, for analysis of atherosclerotic plaques in freshly isolated aortas. It employs ORO staining of the plaques followed by elution of the dye that is subjected to quantitative measurement. Read More

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Analysis of Safety Margin of Lithium Carbonate Against Cardiovascular Adverse Events Assessed in the Halothane-Anesthetized Dogs.

Cardiovasc Toxicol 2018 May 29. Epub 2018 May 29.

Department of Pharmacology, Toho University Graduate School of Medicine, 5-21-16 Omori-nishi, Ota-ku, Tokyo, 143-8540, Japan.

Lithium is one of the classical drugs that have been widely used for treating bipolar disorder. However, several cardiac side effects including sick sinus syndrome, bundle branch block, ventricular tachycardia/fibrillation, non-specific T-wave abnormalities in addition to Brugada-type electrocardiographic changes have been noticed in patients who were given antidepressant, anticonvulsant, and/or antipsychotic drugs besides lithium. In this study, we assessed cardiohemodynamic and electrophysiological effects of lithium carbonate by itself to begin to analyze onset mechanisms of its cardiovascular side effects. Read More

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A Chemosensitizer Drug: Disulfiram Prevents Doxorubicin-Induced Cardiac Dysfunction and Oxidative Stress in Rats.

Cardiovasc Toxicol 2018 May 10. Epub 2018 May 10.

Department of Pharmacology, R. C. Patel Institute of Pharmaceutical Education and Research, Shirpur-Dist. Dhule, Maharashtra, 425405, India.

In the present study, the preventive effects of orally administered disulfiram (DS) against the doxorubicin (DOX)-induced cardiotoxicity were investigated in rats. DS was orally administered for 7 days at doses of 2, 10, and 50 mg/kg/day. DOX (30 mg/kg) was intraperitoneally administered on the 5th day of the initiation of DS treatment. Read More

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Clopidogrel Pharmacogenetics in Iranian Patients Undergoing Percutaneous Coronary Intervention.

Cardiovasc Toxicol 2018 May 18. Epub 2018 May 18.

Medical Genetics Laboratory, Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Valiasr Street, Niyaesh Intersection, Tehran, 1995614331, Iran.

Clopidogrel is used in patients with coronary syndromes and at risk of thrombotic events or receiving percutaneous coronary intervention (PCI) for reducing heart attack and stroke. Here we present genotype and phenotype study of Iranian patients undergoing PCI treated with clopidogrel during a 6-month period of follow-up; common variants of CYP2C19, CYP3A5, CYP3A4, and ABCB1 genes were determined as well as the patients' cardiovascular outcomes to find out the effect of these variants individually and in combination. 388 individuals receiving PCI were enrolled in this study. Read More

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The Acute Effects of Age and Particulate Matter Exposure on Heart Rate and Heart Rate Variability in Mice.

Cardiovasc Toxicol 2018 May 17. Epub 2018 May 17.

Department of Environmental Health and Engineering, Bloomberg School of Public Health, Johns Hopkins University, 615 N. Wolfe St., Baltimore, MD, 21205, USA.

Exposure to ambient particulate matter (PM) is associated with increased cardiac morbidity and mortality with the elderly considered to be the most susceptible. The purpose of this study was to determine if exposure to PM would cause a greater impact on heart regulation in older DBA/2 (D2) male mice as determined by changes in heart rate (HR) and heart rate variability (HRV). D2 mice at the ages of 4, 12, and 19 months were instilled with 100 µg of PM or saline by aspiration. Read More

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Catalpol Promotes the Survival and VEGF Secretion of Bone Marrow-Derived Stem Cells and Their Role in Myocardial Repair After Myocardial Infarction in Rats.

Cardiovasc Toxicol 2018 May 11. Epub 2018 May 11.

Department of Cardiology, Shengjing Hospital of China Medical University, 36 Sanhao Street, Shenyang, 110004, Liaoning, People's Republic of China.

Bone mesenchymal stem cells (BMSCs) transplantation has been recognized as an effective method for the treatment of myocardial infarction (MI). However, its efficacy is always restricted by the low survival of transplanted BMSCs in the ischemic myocardium. The aim of this study was to investigate the effect of catalpol pre-treatment on the survival and vascular endothelial growth factor (VEGF) secretion of BMSCs under oxygen glucose deprivation (OGD) condition and their role in myocardial repair in a rat model of MI. Read More

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Serum miR-30c Level Predicted Cardiotoxicity in Non-small Cell Lung Cancer Patients Treated with Bevacizumab.

Cardiovasc Toxicol 2018 May 8. Epub 2018 May 8.

Department of Thoracic Surgery, TianJin Chest Hospital, 261 Taierzhuang South Rd., Tianjin, 300222, People's Republic of China.

Cardiotoxicity is a common adverse effect induced by drug chemotherapy. miR-30c has been reported to be involved in the progress of heart diseases. In the present study, miR-30c was used to predict the cardiotoxicity in non-small cell lung cancer (NSCLC) patients treated with bevacizumab chemotherapy. Read More

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On the Efficacy of Cardio-Pulmonary Resuscitation and Epinephrine Following Cyanide- and HS Intoxication-Induced Cardiac Asystole.

Cardiovasc Toxicol 2018 Apr 11. Epub 2018 Apr 11.

Division of Pulmonary and Critical Care Medicine, Department of Medicine, College of Medicine, Pennsylvania State University, 500 University Drive, H041, Hershey, PA, 17033, USA.

This study was aimed at determining the efficacy of epinephrine, followed by chest compressions, in producing a return of spontaneous circulation (ROSC) during cyanide (CN)- or hydrogen sulfide (HS)-induced toxic cardiac pulseless electrical activity (PEA) in the rat. Thirty-nine anesthetized rats were exposed to either intravenous KCN (n = 27) or HS solutions (n = 12), at a rate that led to a PEA within less than 10 min. In the group intoxicated by CN, 20 rats were mechanically ventilated and received either epinephrine (0. Read More

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April 2018
3 Reads

Inhibition of MicroRNA-23 Contributes to the Isoflurane-Mediated Cardioprotection Against Oxidative Stress.

Cardiovasc Toxicol 2018 Apr 7. Epub 2018 Apr 7.

Department of Anesthesiology, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, China.

Isoflurane is one of the most frequently used volatile anesthetics in clinical practice for inhalational anesthesia. It is widely studied that isoflurane mediates cardioprotection during multiple pathological processes. However, the precise mechanisms have not been fully elucidated. Read More

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April 2018
3 Reads

Cardiotoxicity in Hematological Diseases: Are the Tyrosine Kinase Inhibitors Imatinib and Nilotinib Safe?

Cardiovasc Toxicol 2018 Apr 3. Epub 2018 Apr 3.

Cardiology Department, Faculty of Medicine, Santa Maria University Hospital (CHLN), Lisbon Academic Medical Centre and Cardiovascular Centre of the University of Lisbon, Av. Prof. Egas Moniz, 1649-035, Lisbon, Portugal.

Chemotherapy-induced cardiotoxicity is a growing concern. The cardiotoxic impact of new drugs such as tyrosine kinase inhibitors is unknown, especially the ones used for chronic myeloid leukemia. We aim to evaluate nilotinib- and imatinib-induced cardiotoxicity. Read More

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April 2018
1 Read

6-Gingerol Ameliorates Behavioral Changes and Atherosclerotic Lesions in ApoE Mice Exposed to Chronic Mild Stress.

Cardiovasc Toxicol 2018 Mar 31. Epub 2018 Mar 31.

First Department of Cardiology, The Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, 33 Beiling Avenue, Shenyang, 110032, People's Republic of China.

Chronic mild stress (CMS) has been demonstrated to contribute to atherosclerosis. 6-gingerol (6-Gin), a phenolic component of ginger (Zingiber officinale), has been shown to exert numerous pharmacological properties, such as anti-inflammatory and cardioprotective effects. Here we investigated the role of CMS in the development of atherosclerosis in high-fat diet (HFD)-fed ApoE mice and evaluated the potential therapeutic effects of 6-Gin. Read More

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March 2018
10 Reads

Methylene Blue Counteracts HS-Induced Cardiac Ion Channel Dysfunction and ATP Reduction.

Cardiovasc Toxicol 2018 Mar 30. Epub 2018 Mar 30.

Division of Pulmonary and Critical Care Medicine, Department of Medicine, Pennsylvania State University College of Medicine, Hershey, PA, 17033, USA.

We have previously demonstrated that methylene blue (MB) counteracts the effects of hydrogen sulfide (HS) cardiotoxicity by improving cardiomyocyte contractility and intracellular Ca homeostasis disrupted by HS poisoning. In vivo, MB restores cardiac contractility severely depressed by sulfide and protects against arrhythmias, ranging from bundle branch block to ventricular tachycardia or fibrillation. To dissect the cellular mechanisms by which MB reduces arrhythmogenesis and improves bioenergetics in myocytes intoxicated with HS, we evaluated the effects of HS on resting membrane potential (E), action potential (AP), Na/Ca exchange current (I), depolarization-activated K currents and ATP levels in adult mouse cardiac myocytes and determined whether MB could counteract the toxic effects of HS on myocyte electrophysiology and ATP. Read More

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March 2018
2 Reads

Evaluation of the Effectiveness of Sugammadex for Digoxin Intoxication: An Experimental Study.

Cardiovasc Toxicol 2018 Mar 16. Epub 2018 Mar 16.

Department of Anesthesiology and Reanimation, School of Medicine, Dokuz Eylül University, İzmir, Turkey.

Previous studies have shown that cyclodextrin group medicines bind to various drugs. The hypothesis of our study is to determine whether sugammadex could bind to digoxin and delay the cardiovascular toxicity of that drug. Twenty-eight sedated Wistar rats were infused with digoxin at 3 mg/h (0. Read More

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March 2018
2 Reads

Catechin Attenuates Coronary Heart Disease in a Rat Model by Inhibiting Inflammation.

Cardiovasc Toxicol 2018 Feb 20. Epub 2018 Feb 20.

Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing, 210029, Jiangsu, China.

Accumulating evidence has established that systemic inflammation is an important pathophysiologic factor of coronary heart disease (CHD). In this study, we investigated whether catechin exerts anti-inflammatory function in CHD rats. CHD model of rats was established by high-fat diet feeding and pituitrin injection. Read More

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February 2018
1 Read

The Role of Intralipid Emulsion in the Rat Model of Digoxin Intoxication.

Cardiovasc Toxicol 2018 Aug;18(4):329-336

Emergency Medicine Department, Fatih Sultan Mehmet Education and Research Hospital, University of Health Sciences, Istanbul, Turkey.

Although the mechanism of action is not well known, intravenous lipid emulsion (ILE) has been shown to be effective in the treatment of lipophilic drug intoxications. It is thought that, ILE probably separates the lipophilic drugs from target tissue by creating a lipid-rich compartment in the plasma. The second theory is that ILE provides energy to myocardium with high-dose free fatty acids activating the voltage-gated calcium channels in the myocytes. Read More

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August 2018
2 Reads

The Involvement of Cytochrome c Oxidase in Mitochondrial Fusion in Primary Cultures of Neonatal Rat Cardiomyocytes.

Cardiovasc Toxicol 2018 Aug;18(4):365-373

Regenerative Medicine Research Center, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, China.

Cytochrome c oxidase (CCO) is a copper-dependent enzyme of mitochondrial respiratory chain. In pressure overload-induced cardiac hypertrophy, copper level and CCO activity are both depressed, along with disturbance in mitochondrial fusion and fission dynamics. Copper repletion leads to recovery of CCO activity and normalized mitochondrial dynamics. Read More

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August 2018
3 Reads

A Fatal Case of Amlodipine Toxicity Following Iatrogenic Hypercalcemia.

Cardiovasc Toxicol 2018 Jun;18(3):290-293

Social Determinants of Health Research Center, Shahid Beheshti University of Medical Sciences, Koodakyar Ave., Daneshju Blvd., Velenjak, Tehran, 1985717443, Iran.

Using calcium salts in management of amlodipine overdose is challenging. A 25-year-old male with known history of adult polycystic kidney disease presented with hypotension, tachycardia, and intact neurological status after ingestion of 450 mg of amlodipine. Immediately, normal saline infusion and norepinephrine were initiated. Read More

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June 2018
5 Reads

Protective Effect of Ellagic Acid Against Sodium Arsenite-Induced Cardio- and Hematotoxicity in Rats.

Cardiovasc Toxicol 2018 Aug;18(4):337-345

Razi Drug Research Center, Iran University of Medical Sciences, Tehran, Iran.

Ellagic acid (EA) is a phenolic constituent in certain fruits and nuts with wide range of biological activities, including potent antioxidant, antidiabetic, anti-inflammatory, anticancer and antimutagen properties. The aim of this study was to evaluate the effect of EA on sodium arsenic (SA)-induced cardio- and hematotoxicity in rats. Animals were divided into five groups. Read More

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August 2018
3 Reads

Protective Effect of Morphine Against the Oxidant-Induced Injury in H9c2 Cells.

Cardiovasc Toxicol 2018 Aug;18(4):374-385

Department of Physiology, Faculty of Science, Charles University, Prague, Czech Republic.

There are some indications that morphine may exert myocardial protective effects under certain conditions. The aim of the present study was to investigate the effect of morphine on viability and oxidative state of H9c2 cells (rat cardiomyoblasts) influenced by oxidative stress that was elicited by exposure to tert-butyl hydroperoxide (t-BHP). Our experiments showed that pretreatment with morphine before the addition of t-BHP markedly improved cell viability. Read More

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August 2018
2 Reads

Intravenous Cocaine Results in an Acute Decrease in Levels of Biomarkers of Vascular Inflammation in Humans.

Cardiovasc Toxicol 2018 Aug;18(4):295-303

Kansas City VA Medical Center, Kansas City, MO, 64128, USA.

Cocaine use causes significant cardiovascular morbidity from its hemodynamic effects. It is less clear whether cocaine promotes atherosclerosis. Vascular inflammation is one of the earliest steps in the pathophysiology of atherosclerosis. Read More

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August 2018
4 Reads

Effect of Kaempferol Pretreatment on Myocardial Injury in Rats.

Cardiovasc Toxicol 2018 Aug;18(4):312-328

Division of Pharmacology and Toxicology, ICAR-Indian Veterinary Research Institute, Izatnagar, Bareilly, Uttar Pradesh, 243122, India.

The present study was undertaken to evaluate the effect of kaempferol in isoprenaline (ISP)-induced myocardial injury in rats. ISP was administered subcutaneously for two subsequent days to induce myocardial injury. Assessment of myocardial injury was done by estimation of hemodynamic functions, myocardial infarcted area, cardiac injury markers, lipid profile, oxidative stress, pro-inflammatory cytokines and histopathology of heart and liver. Read More

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August 2018
2 Reads

Acetaminophen Poisoning May Increase Coronary Artery Disease Risk: A Nationwide Cohort Study.

Cardiovasc Toxicol 2018 Aug;18(4):386-391

Department of Health Services Administration, China Medical University, Taichung, Taiwan.

The purpose of this nationwide cohort study was to investigate the incidence and risk of coronary artery disease (CAD) in patients with acetaminophen (APAP) poisoning. We identified the patients with APAP poisoning and randomly selected comparison patients according to a 1:4 ratio, matching them by age, sex, and the index year using data from the National Health Insurance Research Database from 2000 to 2010. We traced both cohorts until a diagnosis of CAD, loss to follow-up, or the end of 2011. Read More

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August 2018
3 Reads

Necrostatin-1 Protects Against Paraquat-Induced Cardiac Contractile Dysfunction via RIP1-RIP3-MLKL-Dependent Necroptosis Pathway.

Cardiovasc Toxicol 2018 Aug;18(4):346-355

Shanghai Pudong Newarea Healthcare Hospital for Women and Children, Shanghai, 201200, China.

Paraquat is a highly toxic prooxidant that triggers oxidative stress and multi-organ failure including that of the heart. To date, effective treatment of paraquat toxicity is still not established. Necroptosis, a newly discovered form of programmed cell death, was recently shown to be strongly associated with cardiovascular disease. Read More

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August 2018
3 Reads

Cardiovascular Response of Rat Aorta to Di-(2-ethylhexyl) Phthalate (DEHP) Exposure.

Cardiovasc Toxicol 2018 Aug;18(4):356-364

CICS-UBI - Centro de Investigação em Ciências da Saúde, University of Beira Interior, Av. Infante D. Henrique s/n, 6200-506, Covilhã, Portugal.

Phthalates are one of the main constituents of plastic, reaching up to 40% of the total plastic weight, and their main function is to impart flexibility/elasticity to polymers that would otherwise be rigid. Phthalates are known as endocrine disruptors, since they can interfere with hormone homeostasis. Regarding the cardiovascular system, it was already shown the effects of di-(2-ethylhexyl) phthalate (DEHP) exposure with significant changes in several calcium-handling proteins and an increase in the blood pressure of mice offspring, suggesting that DEHP leads to vasocontraction. Read More

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August 2018
5 Reads

The Association Between Myocardial Fibrosis and Depressed Capillary Density in Rat Model of Left Ventricular Hypertrophy.

Cardiovasc Toxicol 2018 Aug;18(4):304-311

Regenerative Medicine Research Center, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, China.

Myocardial fibrogenesis is initiated once the coordination between oxygen supply and demand is disrupted in pressure overload-induced cardiac hypertrophy. Clinical observations showed that myocardial fibrosis did not evenly occur in the hypertrophic myocardium. The present study was undertaken to specifically address differential vulnerabilities to fibrogenesis of different regions in the myocardium subjected to pressure overload-induced hypertrophy. Read More

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August 2018
6 Reads

The Role of Soluble Epoxide Hydrolase Enzyme on Daunorubicin-Mediated Cardiotoxicity.

Cardiovasc Toxicol 2018 Jun;18(3):268-283

Faculty of Pharmacy and Pharmaceutical Sciences, 2142 J Katz Group-Rexall Centre for Pharmacy and Health Research, University of Alberta, Edmonton, AB, T6G 2E1, Canada.

Several studies have demonstrated the role of cytochrome P450 (CYP) and its associated arachidonic acid (AA) metabolites in the anthracyclines-induced cardiac toxicity. However, the ability of daunorubicin (DNR) to induce cardiotoxicity through the modulation of CYP and its associated AA metabolites has not been investigated yet. Therefore, we hypothesized that DNR-induced cardiotoxicity is mediated through the induction of cardiotoxic hydroxyeicosatetraenoic acids and/or the inhibition of cardioprotctive epoxyeicosatrienoic acids (EETs). Read More

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June 2018
12 Reads

Characteristics of Cobalt-Related Cardiomyopathy in Metal Hip Implant Patients: An Evaluation of 15 Published Reports.

Cardiovasc Toxicol 2018 Jun;18(3):206-220

Cardno ChemRisk, 101 2nd St. Suite 700, San Francisco, CA, 94105, USA.

Over 300,000 hip replacements occurred in the USA in 2010, and the frequency is likely increasing annually. Blood Cobalt (Co) concentrations in patients with well-functioning cobalt-chromium (Co-Cr) hip implants are usually elevated above background concentrations relative to the general population. Excessive Co exposure, in rare cases, can result in cardiomyopathy. Read More

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June 2018
5 Reads

A Functional Aryl Hydrocarbon Receptor Genetic Variant, Alone and in Combination with Parental Exposure, is a Risk Factor for Congenital Heart Disease.

Cardiovasc Toxicol 2018 Jun;18(3):261-267

CNR Institute of Clinical Physiology, Via Moruzzi 1, 56124, Pisa, Italy.

Recent experimental studies showed that ablation of the aryl hydrocarbon receptor (AhR) as well as its activation by exogenous ligands disrupt the molecular networks involved in heart formation and function, leading to congenital heart disease (CHD). However, no evidence is available about the role of AhR in humans. We assessed the prevalence of a functional AhR genetic variant (p. Read More

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June 2018
3 Reads

In vivo Analysis of the Anti-atrial Fibrillatory, Proarrhythmic and Cardiodepressive Profiles of Dronedarone as a Guide for Safety Pharmacological Evaluation of Antiarrhythmic Drugs.

Cardiovasc Toxicol 2018 Jun;18(3):242-251

Department of Pharmacology, Toho University Graduate School of Medicine, 5-21-16 Omori-nishi, Ota-ku, Tokyo, 143-8540, Japan.

Anti-atrial fibrillatory, proarrhythmic and cardiodepressive profiles of dronedarone were analyzed using the halothane-anesthetized beagle dogs (n = 4) to create a standard protocol for clarifying both efficacy and adverse effects of anti-atrial fibrillatory drugs. Intravenous administration of dronedarone hydrochloride in doses of 0.3 and 3 mg/kg over 30 s attained the peak plasma concentrations of 61 and 1248 ng/mL, respectively, reflecting sub- to supra-therapeutic ones. Read More

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June 2018
12 Reads

Inhibition of the Voltage-Dependent K Current by the Tricyclic Antidepressant Desipramine in Rabbit Coronary Arterial Smooth Muscle Cells.

Cardiovasc Toxicol 2018 Jun;18(3):252-260

Department of Physiology, Kangwon National University School of Medicine, 1 Kangwondaehak-gil, Chuncheon, 24341, South Korea.

We describe the effect of a tricyclic antidepressant drug desipramine on voltage-dependent K (Kv) currents in freshly isolated rabbit coronary arterial smooth muscle cells using a conventional whole-cell patch clamp technique. Application of desipramine rapidly decreased the Kv current amplitude in a concentration-dependent manner, with an IC value of 5.91 ± 0. Read More

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June 2018
4 Reads

Novel Mesenchymal Stem Cell Strategy in Alleviating Toll-Like Receptor-4, p53 and Nrf2 Signaling in Isoproterenol-Induced Myocardial Infarction in Rat Model.

Cardiovasc Toxicol 2018 Jun;18(3):232-241

Molecular Biology, Therapeutic Chemistry Department, National Research Center, Al Tahrir Street, Dokki, Giza, Egypt.

Mesenchymal stem cells (MSCs) are multipotent stromal cells that merit the differentiation into various cell types. The present study was designed to test the hypothesis that the cardioprotective effect of MSCs transplantation and digoxin treatment is mediated via the regulation of messenger RNA gene expression of pro-inflammatory cytokines and apoptotic markers. Myocardial infarction was induced in Wistar rats via isoproterenol injection in a dose of (85 mg/kg, subcutaneously, twice at an interval of 24 h). Read More

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June 2018
5 Reads

Alleviation of Cardiac Damage by Dietary Fenugreek (Trigonella foenum-graecum) Seeds is Potentiated by Onion (Allium cepa) in Experimental Diabetic Rats via Blocking Renin-Angiotensin System.

Cardiovasc Toxicol 2018 Jun;18(3):221-231

Department of Biochemistry, CSIR-Central Food Technological Research Institute, Mysore, 570 020, India.

Hyperglycemia is one of the metabolic and homeostatic abnormalities that increase the cardiovascular mortality in diabetic patients by increased oxidative stress. We have recently reported amelioration of oxidative stress in cardiac tissue by dietary fenugreek (Trigonella foenum-graecum) seeds and onion (Allium cepa) in streptozotocin-induced diabetic rats. The mechanistic aspects of the cardio-protective influence of dietary fenugreek seeds (10%) and onion (3% powder) both individually and in combination on hyperglycemia-mediated cardiac damage was further investigated in this study on streptozotocin-induced diabetic rats. Read More

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June 2018
4 Reads

Beneficial Role of Some Natural Products to Attenuate the Diabetic Cardiomyopathy Through Nrf2 Pathway in Cell Culture and Animal Models.

Cardiovasc Toxicol 2018 Jun;18(3):199-205

Department of Biochemistry, Centre for Biological Sciences, K. S. Rangasamy College of Arts and Science (Autonomous), Thokkavadi, Tiruchengode, Namakkal District, Tamilnadu, 637215, India.

Diabetic cardiomyopathy, as one of the main cardiac complications in diabetic patients, is identified to connect with oxidative stress that is due to interruption in balance between reactive oxygen species or/and reactive nitrogen species generation and their clearance by antioxidant protection systems. Transcription factor the nuclear factor erythroid 2-related factor 2 (Nrf2) plays a significant role in maintaining the oxidative homeostasis by regulating multiple downstream antioxidants. The Nrf2 plays a significant role in ARE-mediated basal and inducible expression of more than 200 genes that can be grouped into numerous categories as well as antioxidant genes and phase II detoxifying enzymes. Read More

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June 2018
4 Reads

Unanticipated Cardiotoxicity Associated with Targeted Anticancer Therapy in Patients with Hematologic Malignancies Patients: Natural History and Risk Factors.

Cardiovasc Toxicol 2018 Apr;18(2):184-191

Division of Hematology/Oncology, Department of Medicine, University of Florida, 1600 SW Archer Rd., PO Box 100277, Gainesville, FL, 32610, USA.

Our aim is to study unanticipated cardiotoxicity associated with the use of anticancer targeted agents, a problem that remains poorly understood. Using diagnosis codes, we retrospectively identified patients with both hematologic malignancies (HM) and cardiovascular diseases (n = 820 patients). Cardiotoxicity was defined per published criteria. Read More

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April 2018
5 Reads

Predicting Cardiotoxic Effects of Carbon Monoxide Poisoning Using Speckle Tracking Echocardiography.

Cardiovasc Toxicol 2018 Apr;18(2):175-183

Department of Internal Medicine, Gaziantep Training and Research Hospital, 270001, Gaziantep, Turkey.

Carbon monoxide (CO) poisoning could cause significant cardiac injury. This study aimed to evaluate patients with CO poisoning by using speckle tracking echocardiography (STE), a potentially more sensitive technique, to identify left systolic ventricular dysfunction for the first time in the literature. Seventy-two patients who were exposed to CO poisoning were studied. Read More

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April 2018
14 Reads

Xanthine Oxidase Activation Modulates the Endothelial (Vascular) Dysfunction Related to HgCl Exposure Plus Myocardial Infarction in Rats.

Cardiovasc Toxicol 2018 Apr;18(2):161-174

Department of Physiological Sciences, Federal University of Espirito Santo, Vitória, ES, 29040-091, Brazil.

Heavy metal exposure is associated with cardiovascular diseases such as myocardial infarction (MI). Vascular dysfunction is related to both the causes and the consequences of MI. We investigated whether chronic exposure to low doses of mercury chloride (HgCl) worsens MI-induced endothelial dysfunction 7 days after MI. Read More

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April 2018
10 Reads

The Effects of Periostin in a Rat Model of Isoproterenol: Mediated Cardiotoxicity.

Cardiovasc Toxicol 2018 Apr;18(2):142-160

Strategic Product Research and Development Center (SARGEM), Konya Food and Agriculture University, Meram, Konya, Turkey.

Periostin is an extracellular matrix protein from fasciclin family, and it plays an important role in the cell adhesion, migration, and growth of the organism. Periostin prevents apoptosis while stimulating cardiomyocytes. The present study was designed to investigate cardioprotective effects of the recombinant murine periostin peptide administration in a rat model of isoproterenol (ISO)-induced myocardial injury. Read More

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April 2018
4 Reads

Cardiovascular Effects of the MEK Inhibitor, Trametinib: A Case Report, Literature Review, and Consideration of Mechanism.

Cardiovasc Toxicol 2017 Oct;17(4):487-493

Department of Medicine, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

The MEK inhibitor trametinib was approved in 2013 for the treatment of unresectable or metastatic melanoma with a BRAF V600E mutation, the most common pathogenic mutation in melanoma. Trametinib blocks activation of ERK1/2, inhibiting cell proliferation in melanoma. ERK1/2 also protects against multiple types of cardiac insult in mouse models. Read More

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October 2017
5 Reads

Asiatic Acid Ameliorates Doxorubicin-Induced Cardiac and Hepato-Renal Toxicities with Nrf2 Transcriptional Factor Activation in Rats.

Cardiovasc Toxicol 2018 Apr;18(2):131-141

Drug Discovery Laboratory, Department of Pharmacology, R. C. Patel Institute of Pharmaceutical Education & Research Center, Karvand Naka, Shirpur, Dist. Dhule, Maharashtra, 425405, India.

Asiatic acid (AA), a pentacyclic triterpenoid, is a key phytoconstituent of Centella asiatica. AA is a patented as a cytotoxic substance, and it exerts cytotoxicity against Hep3B, Hela and MCF-7 cell lines. However, pentacyclic triterpenoids also modulate the expression and transcriptional activities of Nrf2 and exert cytoprotective effects. Read More

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April 2018
8 Reads

Is There a Place for Ozone Therapy in Patients with Heart Failure?

Cardiovasc Toxicol 2017 Oct;17(4):496-497

Research Unit, Dr. Negrín University Hospital, 35019, Las Palmas, Canary Islands, Spain.

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October 2017
5 Reads

Diosmin Prevents Isoproterenol-Induced Heart Mitochondrial Oxidative Stress in Rats.

Cardiovasc Toxicol 2018 Apr;18(2):120-130

Department of Chemistry, Government Arts College, C.Mutlur, Chidambaram, Tamil Nadu, India.

Cardiac mitochondrial oxidative stress causes mitochondrial damage that plays an important role in the pathology of myocardial infarction. The preventive effects of diosmin on cardiac mitochondrial oxidative stress in isoproterenol-induced myocardial infarcted rats were evaluated. Rats were pretreated with diosmin (10 mg/kg body weight) daily for 10 days. Read More

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April 2018
4 Reads

Quercetin Reverses Altered Energy Metabolism in the Heart of Rats Receiving Adriamycin Chemotherapy.

Cardiovasc Toxicol 2018 Apr;18(2):109-119

Pharmacology Department, Faculty of Veterinary Medicine, Zagazig University, Zagazig, Egypt.

The primary aim of this study was to find the potential modulatory roles of quercetin (QUE) against Adriamycin (ADR)-induced cardiotoxicity. A total of 50 rats were assigned to five groups: a control group, an ADR-treated group, a QUE-treated group, a prophylaxis-cotreated group, and a therapeutic-cotreated group, respectively. QUE exhibited a significant cardioprotective effect, particularly, when it was administered prior to and concurrently with ADR treatment (prophylaxis-cotreated group). Read More

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April 2018
10 Reads

A Case of Severe, Refractory Hypotension After Amlodipine Overdose.

Cardiovasc Toxicol 2018 Apr;18(2):192-197

Tampa General Hospital, 1 Tampa General Circle, Tampa, FL, 33606, USA.

Calcium channel blockers (CCBs) are responsible for a substantial portion of the mortality associated with cardiovascular medication overdose cases. Amlodipine, a dihydropyridine CCB, can cause prolonged hypotension in overdose. This report describes a severe amlodipine overdose case that was refractory to multiple therapeutic approaches. Read More

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April 2018
9 Reads

Modulatory Effect of Aerobic Exercise Training on Doxorubicin-Induced Cardiotoxicity in Rats with Different Ages.

Cardiovasc Toxicol 2018 Feb;18(1):33-42

College of Physical Education and Sport Sciences, Department of Sport Physiology, University of Mazandaran (UMZ), Pasdaran Street, 47415, P.O. Box: 416, Babolsar, Mazandaran, Iran.

We tested the hypothesis that aerobic exercise training (AET) would modulate doxorubicin-induced cardiotoxicity in rats of various ages. Wistar male rats (n = 72) were assigned to three groups (young, adult, and elderly) with three subgroups for each age: doxorubicin (DG, n = 8), AET + doxorubicin (AETDG, n = 8), AET + Saline (AETSG, n = 8). Following the AET intervention, rats were anesthetized and killed to collect heart tissues in order to determine heat shock protein 70 (HSP70), superoxide dismutase (SOD), malondialdehyde (MDA), interleukin-10 (IL10), and c-reactive protein (CRP). Read More

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February 2018
4 Reads

Amitriptyline May Have Possibility to Induce Brugada Syndrome Rather than Long QT Syndrome.

Cardiovasc Toxicol 2018 Feb;18(1):91-98

Department of Pharmacology, Toho University Graduate School of Medicine, 5-21-16 Omori-nishi, Ota-ku, Tokyo, 143-8540, Japan.

Amitriptyline has been reported to induce long QT syndrome in addition to Brugada syndrome. We qualitatively and quantitatively analyzed the potential of amitriptyline to induce these lethal syndromes by using the halothane-anesthetized dogs (n = 6). Amitriptyline was intravenously administered in doses of 0. Read More

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February 2018
12 Reads

The Cardiovascular Effect of Single Injection and Toxicologic Effects of Repetitive 2-Week Intravenous Administration of Activin A/BMP-2 Chimera in Beagle Dog.

Cardiovasc Toxicol 2018 Feb;18(1):76-83

Department of Orthopedic Surgery, Seoul National University, College of Medicine, 101, Daehak-ro, Jongno-gu, Seoul, 03080, Korea.

This study was performed for the purpose to evaluate the effect of activin A/BMP-2 chimera (AB204) on cardiovascular system and toxicological effect in beagle dogs. When administered AB204 at the dose of 0.32 mg/kg via intravenous injection in beagle dogs, there were no changes in systolic, diastolic and mean blood pressure as well as in pulse rate, in addition that there were no differences in ORS complex, PR interval, R-R interval, QT interval and QTcV interval on the electrocardiography. Read More

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February 2018
9 Reads

Cardiovascular Effects and Fatality May Differ According to the Formulation of Glyphosate Salt Herbicide.

Cardiovasc Toxicol 2018 Feb;18(1):99-107

Department of Emergency Medicine, Chonnam National University Medical School, Hak Dong 8, Donggu, Gwangju, 501-747, South Korea.

This study aimed to compare adverse cardiovascular events and fatalities and to identify the risk factors for fatalities associated with the glyphosate salt herbicide formulation. Additionally, we examined whether glyphosate ammonium salt herbicides increased serum ammonia levels. One hundred forty-seven patients were divided into an ammonium group (glyphosate ammonium salt herbicide) and an isopropylamine (IPA) group (glyphosate IPA salt herbicide) according to the type of glyphosate salt formulation ingested. Read More

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February 2018
5 Reads