1,729,400 results match your criteria Cardiovascular surgery London England[Journal]


Impact of Gut Dysbiosis on Neurohormonal Pathways in Chronic Kidney Disease.

Diseases 2019 Feb 13;7(1). Epub 2019 Feb 13.

Division of Nephrology, Department of Medicine, University of California-Irvine, Irvine, CA 92697, USA.

Chronic kidney disease (CKD) is a worldwide major health problem. Traditional risk factors for CKD are hypertension, obesity, and diabetes mellitus. Recent studies have identified gut dysbiosis as a novel risk factor for the progression CKD and its complications. Read More

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http://dx.doi.org/10.3390/diseases7010021DOI Listing
February 2019

A Systematic Review of the Association of Skipping Breakfast with Weight and Cardiometabolic Risk Factors in Children and Adolescents. What Should We Better Investigate in the Future?

Nutrients 2019 Feb 13;11(2). Epub 2019 Feb 13.

SCDU of Pediatrics, Department of Health Sciences, University of Piemonte Orientale, 28100 Novara, Italy.

The incidence of skipping breakfast in pediatric subjects is rising, and a relationship with overweight (OW) and obesity (OB) has been shown. Associations with cardiovascular outcomes and skipping breakfast in adults have been reported. The purpose of this systematic review was to summarize the association of skipping breakfast with body weight and metabolic outcomes in the pediatric population. Read More

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http://dx.doi.org/10.3390/nu11020387DOI Listing
February 2019

Folic Acid and Vitamin B12 Administration in CKD, Why Not?

Nutrients 2019 Feb 13;11(2). Epub 2019 Feb 13.

Department of Experimental Diagnostic and Specialty Medicine (DIMES), Nephrology, Dialysis and Renal Transplant Unit, S. Orsola Hospital, University of Bologna, 40138 Bologna, Italy.

Patients affected by chronic kidney disease (CKD) or end-stage renal disease (ESRD) experience a huge cardiovascular risk and cardiovascular events represent the leading causes of death. Since traditional risk factors cannot fully explain such increased cardiovascular risk, interest in non-traditional risk factors, such as hyperhomocysteinemia and folic acid and vitamin B12 metabolism impairment, is growing. Although elevated homocysteine blood levels are often seen in patients with CKD and ESRD, whether hyperhomocysteinemia represents a reliable cardiovascular and mortality risk marker or a therapeutic target in this population is still unclear. Read More

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http://dx.doi.org/10.3390/nu11020383DOI Listing
February 2019

Molecular Implications of Natriuretic Peptides in the Protection from Hypertension and Target Organ Damage Development.

Int J Mol Sci 2019 Feb 13;20(4). Epub 2019 Feb 13.

Department of Clinical and Molecular Medicine, School of Medicine and Psychology, Sapienza University of Rome, 00189 Rome, Italy.

The pathogenesis of hypertension, as a multifactorial trait, is complex. High blood pressure levels, in turn, concur with the development of cardiovascular damage. Abnormalities of several neurohormonal mechanisms controlling blood pressure homeostasis and cardiovascular remodeling can contribute to these pathological conditions. Read More

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http://dx.doi.org/10.3390/ijms20040798DOI Listing
February 2019

Sleep, Autonomic Nervous Function and Atherosclerosis.

Int J Mol Sci 2019 Feb 13;20(4). Epub 2019 Feb 13.

Department of Internal Medicine, Division of Diabetes, Endocrinology and Metabolism, Hyogo College of Medicine, Nishinomiya, Hyogo 663-8501, Japan.

Behavioral and psychosocial factors related to development of cardiovascular disease have been gaining increased attention. Notably, sleep is considered to be one of the most important behavioral factors involved in progression of atherosclerosis and cardiovascular events, with autonomic nervous function a potential mechanism. Several studies have shown associations of sleep and autonomic dysfunction with major surrogate markers of atherosclerosis, such as carotid intima-media thickness and arterial stiffness. Read More

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http://dx.doi.org/10.3390/ijms20040794DOI Listing
February 2019

Coronary Physiology in the Cardiac Catheterization Laboratory.

J Clin Med 2019 Feb 18;8(2). Epub 2019 Feb 18.

Yale-New Haven Hospital, Yale School of Medicine, New Haven, CT 06510, USA.

Coronary angiography has been the principle modality for assessing the severity of atherosclerotic coronary artery disease for several decades. However, there is a complex relationship between angiographic coronary stenosis and the presence or absence of myocardial ischemia. Recent technological advances now allow for the assessment of coronary physiology in the catheterization laboratory at the time of diagnostic coronary angiography. Read More

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http://dx.doi.org/10.3390/jcm8020255DOI Listing
February 2019

Cardiovascular Health Benefits of Exercise Training in Persons Living with Type 1 Diabetes: A Systematic Review and Meta-Analysis.

J Clin Med 2019 Feb 17;8(2). Epub 2019 Feb 17.

Physical Activity Promotion and Chronic Disease Prevention Unit, University of British Columbia, Vancouver, BC V6T 1Z4, Canada.

Exercise is advocated in the management of type 1 diabetes (T1D), but the effects of different forms of exercise training on cardiovascular risk factors in T1D still remain unclear. The aim of this study was to conduct a systematic review and meta-analysis on exercise training for cardiovascular risk factors in T1D. Six electronic databases were systematically searched for randomized or non-randomized controlled studies reporting associations between exercise training and cardiovascular risk factors in T1D. Read More

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http://dx.doi.org/10.3390/jcm8020253DOI Listing
February 2019

The Contribution of Homocysteine Metabolism Disruption to Endothelial Dysfunction: State-of-the-Art.

Int J Mol Sci 2019 Feb 17;20(4). Epub 2019 Feb 17.

Institute for Medicines and Pharmaceutical Sciences (iMed.UL), Faculty of Pharmacy, University of Lisbon, 1649-003 Lisbon, Portugal.

Homocysteine (Hcy) is a sulfur-containing non-proteinogenic amino acid formed during the metabolism of the essential amino acid methionine. Hcy is considered a risk factor for atherosclerosis and cardiovascular disease (CVD), but the molecular basis of these associations remains elusive. The impairment of endothelial function, a key initial event in the setting of atherosclerosis and CVD, is recurrently observed in hyperhomocysteinemia (HHcy). Read More

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http://dx.doi.org/10.3390/ijms20040867DOI Listing
February 2019

Exosome in Cardiovascular Diseases: A Complex World Full of Hope.

Cells 2019 Feb 17;8(2). Epub 2019 Feb 17.

Department of Biomedical Sciences, University of Padova, 35131 Padua, Italy.

Exosomes are a subgroup of extracellular vesicles containing a huge number of bioactive molecules. They represent an important means of cell communication, mostly between different cell populations, with the purpose of maintaining tissue homeostasis and coordinating the adaptive response to stress. This type of intercellular communication is important in the cardiovascular field, mainly due to the fact that the heart is a complex multicellular system. Read More

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http://dx.doi.org/10.3390/cells8020166DOI Listing
February 2019

Estimating Ground-Level Concentrations of Multiple Air Pollutants and Their Health Impacts in the Huaihe River Basin in China.

Int J Environ Res Public Health 2019 Feb 16;16(4). Epub 2019 Feb 16.

State Key Laboratory of Resources and Environmental Information System, Institute of Geographic Sciences and Natural Resources Research, Chinese Academy of Sciences, Beijing 100101, China.

Air pollutants existing in the environment may have negative impacts on human health depending on their toxicity and concentrations. Remote sensing data enable researchers to map concentrations of various air pollutants over vast areas. By combining ground-level concentrations with population data, the spatial distribution of health impacts attributed to air pollutants can be acquired. Read More

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http://dx.doi.org/10.3390/ijerph16040579DOI Listing
February 2019

Biobanking: Objectives, Requirements, and Future Challenges-Experiences from the Munich Vascular Biobank.

J Clin Med 2019 Feb 16;8(2). Epub 2019 Feb 16.

DZHK (German Centre for Cardiovascular Research), Munich Heart Alliance, 80636 Munich, Germany.

Collecting biological tissue samples in a biobank grants a unique opportunity to validate diagnostic and therapeutic strategies for translational and clinical research. In the present work, we provide our long-standing experience in establishing and maintaining a biobank of vascular tissue samples, including the evaluation of tissue quality, especially in formalin-fixed paraffin-embedded specimens (FFPE). Our Munich Vascular Biobank includes, thus far, vascular biomaterial from patients with high-grade carotid artery stenosis ( = 1567), peripheral arterial disease ( = 703), and abdominal aortic aneurysm ( = 481) from our Department of Vascular and Endovascular Surgery (January 2004⁻December 2018). Read More

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http://dx.doi.org/10.3390/jcm8020251DOI Listing
February 2019

Coenzyme Q10 and Degenerative Disorders Affecting Longevity: An Overview.

Antioxidants (Basel) 2019 Feb 16;8(2). Epub 2019 Feb 16.

School of Pharmacy, Liverpool John Moores University, L3 5UA Liverpool, UK.

Longevity is determined by a number of factors, including genetic, environmental and lifestyle factors. A major factor affecting longevity is the development of degenerative disorders such as cardiovascular disease, diabetes, kidney disease and liver disease, particularly where these occur as co-morbidities. In this article, we review the potential role of supplementation with coenzyme Q10 (CoQ10) for the prevention or management of these disorders. Read More

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http://dx.doi.org/10.3390/antiox8020044DOI Listing
February 2019

A Longitudinal Examination of the Social-Ecological Correlates of Exercise in Men and Women Following Cardiac Rehabilitation.

J Clin Med 2019 Feb 16;8(2). Epub 2019 Feb 16.

School of Kinesiology and Health Science, York University-Bethune 368, 4700 Keele St., Toronto, ON M3J 1P3, Canada.

Cardiac patients who engage in ≥150 min of moderate- to vigorous-intensity physical activity (MVPA)/week have lower mortality, yet MVPA declines even following cardiac rehabilitation (CR), and is lower in women. A randomized trial of nine socioecological theory-based exercise facilitation contacts over 50 weeks versus usual care (1:1 parallel arms) was undertaken (NCT01658683). The tertiary objective, as presented in this paper, was to test whether the intervention impacted socioecological elements, and in turn their association with MVPA. Read More

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http://dx.doi.org/10.3390/jcm8020250DOI Listing
February 2019

Screening of Suitable Ionic Liquids as Green Solvents for Extraction of Eicosapentaenoic Acid (EPA) from Microalgae Biomass Using COSMO-RS Model.

Molecules 2019 Feb 16;24(4). Epub 2019 Feb 16.

International Institute for Halal Research and Training (INHART), International Islamic University Malaysia, Gombak, Kuala Lumpur 50728, Malaysia.

Omega-3 poly unsaturated fatty acids (PUFA) particularly eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA), have many health benefits including reducing the risk of cancer and cardiovascular disease. Recently, the use of ionic liquids (ILs) in lipid extraction from microalgae provides the potential to overcome common drawbacks, offers several other benefits. To date, very limited researches are available to focus on extracting microalgae lipid and PUFA in particular by using ILs. Read More

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http://dx.doi.org/10.3390/molecules24040713DOI Listing
February 2019

Comparison of 30-Day MACE between Immediate versus Staged Complete Revascularization in Acute Myocardial Infarction with Multivessel Disease, and the Effect of Coronary Lesion Complexity.

Medicina (Kaunas) 2019 Feb 15;55(2). Epub 2019 Feb 15.

Department of Cardiology, Kosuyolu Heart Education and Research Hospital, University of Health Sciences, 34844 Istanbul, Turkey.

In patients with acute myocardial infarction and multivessel disease, the timing of intervention to non-culprit lesions is still a matter of debate, especially in patients without shock. This study aimed to compare the effect of multivessel intervention, performed at index percutaneous coronary intervention (PCI) (MVI-I) or index hospitalization (MVI-S), on the 30-day results of acute myocardial infarction (AMI), and to investigate the effect of coronary lesion complexity assessed by the Syntax (Sx) score on the timing of multivessel intervention. We enrolled 180 patients with MVI-I, and 425 patients with MVI-S. Read More

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http://dx.doi.org/10.3390/medicina55020051DOI Listing
February 2019

Targeted Gene Delivery through the Respiratory System: Rationale for Intratracheal Gene Transfer.

J Cardiovasc Dev Dis 2019 Feb 15;6(1). Epub 2019 Feb 15.

Cardiovascular Research Center, Department of Cardiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.

Advances in DNA- and RNA-based technologies have made gene therapy suitable for many lung diseases, especially those that are hereditary. The main objective of gene therapy is to deliver an adequate amount of gene construct to the intended target cell, achieve stable transduction in target cells, and to produce a clinically therapeutic effect. This review focuses on the cellular organization in the normal lung and how gene therapy targets the specific cell types that are affected by pulmonary disorders caused by genetic mutations. Read More

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http://dx.doi.org/10.3390/jcdd6010008DOI Listing
February 2019

Adrenaline Improves Platelet Reactivity in Ticagrelor-Treated Healthy Volunteers.

Thromb Haemost 2019 Feb 19. Epub 2019 Feb 19.

Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

Background:  Administration of agents that enhance platelet reactivity may reduce the perioperative bleeding risk in patients treated with the adenosine diphosphate (ADP)-receptor antagonist ticagrelor. Adrenaline potentiates ADP-induced aggregation and activation in blood samples from ticagrelor-treated patients, but it has not previously been evaluated in vivo.

Methods:  Ten healthy male subjects were included in an interventional study. Read More

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http://dx.doi.org/10.1055/s-0039-1683461DOI Listing
February 2019

Physical activity in breast cancer survivors: A systematic review and meta-analysis on overall and breast cancer survival.

Breast 2019 Feb 12;44:144-152. Epub 2019 Feb 12.

Department of Hygiene, Epidemiology, and Medical Statistics, School of Medicine, National and Kapodistrian University of Athens, 75 M. Asias Street, Goudi, 115 27, Athens, Greece. Electronic address:

Aim: To further quantify the association between physical activity (PA) after breast cancer diagnosis and all-cause mortality, breast cancer mortality and/or breast cancer recurrence.

Methods And Results: PubMed was searched until November 2017 for observational studies investigating any type of PA in association with total mortality, breast cancer mortality and/or breast cancer recurrence among women with breast cancer diagnosis. Pooled hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using random-effects models for highest versus lowest categories of PA. Read More

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http://dx.doi.org/10.1016/j.breast.2019.02.001DOI Listing
February 2019

Seizure and epilepsy publication in nonneurology journals.

Epilepsy Behav 2019 Feb 16;93:7-11. Epub 2019 Feb 16.

Department of Neurology, University of Arkansas for Medical Sciences, Little Rock, AR, United States of America; Minnesota Epilepsy Group, P.A., St. Paul, MN, United States of America.

Purpose: The prevalence and characteristics of seizure and epilepsy research published in nonneurology journals are unknown. Characterizing this published research allows for insight into the relevance of seizures and epilepsy in other specialties and may increase opportunity for cross-specialty collaboration.

Methods: In this observational study, we reviewed the top five highly cited clinical journals within eleven specialties in the InCites Journal Citation Reports (JCR) database (2016). Read More

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http://dx.doi.org/10.1016/j.yebeh.2019.01.032DOI Listing
February 2019

Relationship between type of unprovoked venous thromboembolism and cancer location: An individual patient data meta-analysis.

Thromb Res 2019 Feb 13;176:79-84. Epub 2019 Feb 13.

Department of Medicine, University of Ottawa, Ottawa Hospital Research Institute, Ottawa, Canada.

Background: Unprovoked venous thromboembolism (VTE) may be the first manifestation of an underlying cancer. We aimed to assess the period prevalence of occult cancer detection stratified by VTE location (deep vein thrombosis [DVT], pulmonary embolism [PE] or both) and the anatomical relationship between occult cancer and VTE.

Methods: Post-hoc analysis of a systematic review and individual patient data meta-analysis of adults with unprovoked VTE with at least 12 months of follow-up. Read More

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http://dx.doi.org/10.1016/j.thromres.2019.02.011DOI Listing
February 2019

PD-L1 expression, tumor mutational burden and cancer gene mutations are stronger predictors of benefit from immune checkpoint blockade than HLA class I genotype in non-small cell lung cancer.

J Thorac Oncol 2019 Feb 16. Epub 2019 Feb 16.

Department of Thoracic / Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd., Unit 0432, Houston, Texas, 77030, United States of America. Electronic address:

Introduction: Immune checkpoint blockade (ICB) has revolutionized the treatment of non-small cell lung cancer (NSCLC), but only ∼15% of patients achieve durable benefit. Understanding resistance mechanisms to ICB is pivotal in developing more effective treatment strategies. Recent studies showed human leukocyte antigen (HLA) class I heterozygosity might be important in mediating benefit from ICB. Read More

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http://dx.doi.org/10.1016/j.jtho.2019.02.008DOI Listing
February 2019

Engineering Human Ventricular Heart Tissue Based on Macroporous Iron Oxide Scaffolds.

Acta Biomater 2019 Feb 16. Epub 2019 Feb 16.

Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Shanghai Key Laboratory of Clinical Geriatric Medicine, Fudan University, Shanghai 200032, China; Shanghai Key Laboratory of Birth Defect, Children's Hospital of Fudan University, Shanghai, 201102 China. Electronic address:

Myocardial infarction (MI) is a primary cardiovascular disease threatening human health and quality of life worldwide. The development of engineered heart tissues (EHTs) as a transplantable artificial myocardium provides a promising therapy for MI. Since most MIs occur at the ventricle, engineering ventricular-specific myocardium is therefore more desirable for future applications. Read More

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http://dx.doi.org/10.1016/j.actbio.2019.02.024DOI Listing
February 2019

Social-housing and use of double-decker cages in rat telemetry studies.

J Pharmacol Toxicol Methods 2019 Feb 16. Epub 2019 Feb 16.

National Centre for the Replacement, Refinement & Reduction of Animals in Research (NC3Rs), Gibbs Building, 215 Euston Rd, London NW1 2BE, UK.

Rat telemetry is widely used for biomedical research purposes and is used routinely in early pre-clinical drug development to screen for the potential cardiovascular risk of candidate drugs. Historically, these studies have been conducted in individually housed conditions which can impact significantly on an animal's welfare. Here we present data from a survey of pharmaceutical companies and contract research organisations to define current industry practices relating to the housing of rats during telemetry studies and to expand and complement a similar project in non-rodents. Read More

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http://dx.doi.org/10.1016/j.vascn.2019.02.005DOI Listing
February 2019

Association of copeptin, a surrogate marker for arginine vasopressin secretion, with insulin resistance: influence of adolescence and psychological stress.

Peptides 2019 Feb 16. Epub 2019 Feb 16.

Department of Medicine, Amager and Hvidovre Hospital in Glostrup, University of Copenhagen, Glostrup, Denmark; Department of Medicine O, Endocrine Unit, Herlev and Gentofte Hospital, University of Copenhagen, Herlev, Denmark.

In middle-aged and elderly individuals, circulating copeptin concentrations, a surrogate marker for arginine vasopressin (AVP) secretion, associates with insulin resistance (IR). Whether this association is present in adolescents and young adults is unclear. Because psychological stress associates with higher circulating copeptin concentrations and IR, it has been speculated that increased AVP secretion could be a link between psychological stress and IR. Read More

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http://dx.doi.org/10.1016/j.peptides.2019.02.005DOI Listing
February 2019

Ca/calmodulin-dependent protein kinase II regulation by inhibitor 1 of protein phosphatase 1 alleviates necroptosis in high glucose-induced cardiomyocytes injury.

Biochem Pharmacol 2019 Feb 16. Epub 2019 Feb 16.

Department of Pharmacology, School of Pharmacy, Key Laboratory of Inflammation and Molecular Drug Target of Jiangsu Province, Nantong University, Nantong 226001, China. Electronic address:

Ca/calmodulin-dependent protein kinase II (CaMKII) plays an important role in the cardiovascular system. However, the potential protective role of inhibitor 1 of protein phosphatase 1 (I1PP1), which is able to regulate CaMKII, in high glucose-induced cardiomyocytes injury remains unknown. In the present study, cardiomyocytes were transfected with I1PP1 adenovirus to inhibit protein phosphatase 1 (PP1) expression. Read More

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http://dx.doi.org/10.1016/j.bcp.2019.02.022DOI Listing
February 2019

Readmissions following hospitalisations for cardiovascular disease: a scoping review of the Australian literature.

Aust Health Rev 2019 Feb 20. Epub 2019 Feb 20.

International studies suggest high rates of readmissions after cardiovascular hospitalisations, but the burden in Australia is uncertain. We summarised the characteristics, frequency, risk factors of readmissions and interventions to reduce readmissions following cardiovascular hospitalisation in Australia.A scoping review of the published literature from 2000-2016 was performed using Medline, EMBASE and Cumulative Index to Nursing and Allied Health Literature (CINAHL) databases and relevant grey literature. Read More

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http://dx.doi.org/10.1071/AH18028DOI Listing
February 2019

Modification with CREKA improves cell retention in a rat model of myocardial ischemia reperfusion.

Stem Cells 2019 Feb 19. Epub 2019 Feb 19.

Department of Cardiology, Zhongshan Hospital, Fudan University. Shanghai Institute of Cardiovascular Diseases, 180 Fenglin Road, Shanghai, China.

Poor cell homing limits the efficacy of cardiac cellular therapy. The homing peptide, cysteine-arginine-glutamic acid-lysine-alanine (CREKA), targets fibrin effectively which is involved in the repair process of tissue injury. Here, we assessed if CREKA-modified stem cells had enhanced fibrin-mediated homing ability resulting in better functional recovery and structural preservation in a rat myocardial injury model. Read More

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http://dx.doi.org/10.1002/stem.2983DOI Listing
February 2019

Prevalence and associated factors of uncontrolled blood pressure among hypertensive patients in the rural communities in the central areas in Thailand: A cross-sectional study.

PLoS One 2019 19;14(2):e0212572. Epub 2019 Feb 19.

Department of Military and Community Medicine, Phramongkutklao College of Medicine, Bangkok, Thailand.

Introduction: Hypertension is a common cardiovascular disease at present. Uncontrolled blood pressure leads to further complications including heart attack, stroke and chronic kidney disease. In Thailand, most of the information related to this issue is collected by hospitals or hospital-based organizations rather than at the community level. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212572PLOS
February 2019
3.234 Impact Factor

Clinical indicators of adrenal insufficiency following discontinuation of oral glucocorticoid therapy: A Danish population-based self-controlled case series analysis.

PLoS One 2019 19;14(2):e0212259. Epub 2019 Feb 19.

Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark.

Background: Biochemical adrenal insufficiency induced by glucocorticoid treatment is prevalent, but data on the clinical implications are sparse. We investigated clinical consequences of glucocorticoid-induced adrenal insufficiency after oral glucocorticoid cessation.

Methods: We conducted a Danish population-based self-controlled case series utilizing medical registries. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212259PLOS
February 2019

Screening for inhibitor of episomal DNA identified dicumarol as a hepatitis B virus inhibitor.

PLoS One 2019 19;14(2):e0212233. Epub 2019 Feb 19.

Graduate School of Biostudies, Kyoto University, Kyoto, Japan.

Currently, there is no available therapy to eradicate hepatitis B virus (HBV) in chronically infected individuals. This is due to the difficulty in eliminating viral covalently closed circular (ccc) DNA, which is central to the gene expression and replication of HBV. We developed an assay system for nuclear circular DNA using an integration-deficient lentiviral vector. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212233PLOS
February 2019

Identifying individual risk rare variants using protein structure guided local tests (POINT).

PLoS Comput Biol 2019 Feb 19;15(2):e1006722. Epub 2019 Feb 19.

Department of Statistics, North Carolina State University, Raleigh, North Carolina, United States of America.

Rare variants are of increasing interest to genetic association studies because of their etiological contributions to human complex diseases. Due to the rarity of the mutant events, rare variants are routinely analyzed on an aggregate level. While aggregation analyses improve the detection of global-level signal, they are not able to pinpoint causal variants within a variant set. Read More

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http://dx.doi.org/10.1371/journal.pcbi.1006722DOI Listing
February 2019

Circulating Microparticles Are Elevated in Treated HIV -1 Infection and Are Deleterious to Endothelial Cell Function.

J Am Heart Assoc 2019 Feb;8(4):e011134

1 Integrative Vascular Biology Laboratory Department of Integrative Physiology University of Colorado Boulder Boulder CO.

Background Circulating microparticles have emerged as biomarkers and effectors of vascular disease. Elevated rates of cardiovascular disease are seen in HIV -1-seropositive individuals. The aims of this study were to determine: (1) if circulating microparticles are elevated in antiretroviral therapy-treated HIV -1-seropositive adults; and (2) the effects of microparticles isolated from antiretroviral therapy -treated HIV -1-seropositive adults on endothelial cell function, in vitro. Read More

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http://dx.doi.org/10.1161/JAHA.118.011134DOI Listing
February 2019

Public Perceptions on Why Women Receive Less Bystander Cardiopulmonary Resuscitation Than Men in Out-of-Hospital Cardiac Arrest.

Circulation 2019 Feb;139(8):1060-1068

Center for Women's Health Research (S.M.P., C.K., S.L.D.), Department of Medicine, University of Colorado School of Medicine, Aurora.

Background: Women who suffer an out-of-hospital cardiac arrest receive bystander cardiopulmonary resuscitation (CPR) less often than men. Understanding public perceptions of why this occurs is a necessary first step toward equitable application of this potentially life-saving intervention.

Methods: We conducted a national survey of members of the public using Mechanical Turk, Amazon's crowdsourcing platform, to determine reasons why women might receive bystander CPR less often than men. Read More

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http://dx.doi.org/10.1161/CIRCULATIONAHA.118.037692DOI Listing
February 2019

Sex Differences in the Prevalence of, and Trends in, Cardiovascular Risk Factors, Treatment, and Control in the United States, 2001 to 2016.

Circulation 2019 Feb;139(8):1025-1035

The George Institute for Global Health, University of Oxford, Oxford, UK (S.A.E.P., M.W.).

Background: Improvements have been made in the treatment and control of some but not all major cardiovascular risk factors in the United States. It remains unclear whether women and men have benefited equally.

Methods: Data from the 2001 to 2002 through the 2015 to 2016 US National Health and Nutrition Examination Survey on adults aged 20 to 79 years were used. Read More

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http://dx.doi.org/10.1161/CIRCULATIONAHA.118.035550DOI Listing
February 2019

Management of Cardiovascular Disease in Women With Breast Cancer.

Circulation 2019 Feb;139(8):1110-1120

Division of Cardiology, MedStar Heart and Vascular Institute, MedStar Washington Hospital Center, Georgetown University, Washington, DC (A.B.).

Cardio-oncology is a rapidly developing field which seeks to improve patient outcomes through enhanced clinical and research collaboration across the disciplines of oncology and cardiology. Breast cancer (BC) is the most common cancer diagnosis among women in the United States and, as decades of research have resulted in decreased mortality rates, there has been an increasing focus on reducing short- and long-term treatment toxicity and improving morbidity among survivors. Preexisting or emergent cardiovascular disease in a patient with BC requires a multidisciplinary, team-based approach to balance the need for curative cancer treatment while preventing increased cardiovascular disease morbidity and mortality. Read More

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http://dx.doi.org/10.1161/CIRCULATIONAHA.118.039371DOI Listing
February 2019

A Review of the Role of Breast Arterial Calcification for Cardiovascular Risk Stratification in Women.

Circulation 2019 Feb;139(8):1094-1101

Division of Cardiovascular Medicine, Department of Medicine, University of California, San Diego.

Cardiovascular disease continues to be the leading cause of death among women in the United States. One of the barriers to improving cardiovascular disease outcomes in women is the lack of reliable, effective screening modalities. Breast arterial calcification has emerged as a potential risk stratification tool. Read More

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http://dx.doi.org/10.1161/CIRCULATIONAHA.118.038092DOI Listing
February 2019

Third Annual Go Red for Women Issue.

Circulation 2019 Feb;139(8):999-1000

Department of Medicine, Cardiology Section, Winters Center for Heart Failure Research, Cardiovascular Research Institute, Baylor College of Medicine, DeBakey VA Medical Center, Houston, TX (B.B.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.119.039778DOI Listing
February 2019

Why Are Young Black Women at High Risk for Cardiovascular Disease?

Circulation 2019 Feb;139(8):1003-1004

Department of Population Health, New York University School of Medicine, New York, NY (J.K., T.M.S.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.118.037689DOI Listing
February 2019

Association Between Female Corresponding Authors and Female Co-Authors in Top Contemporary Cardiovascular Medicine Journals.

Circulation 2019 Feb;139(8):1127-1129

Department of Medicine, Stanford University School of Medicine, Stanford, CA. (D.O., R.H., F.R.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.118.037763DOI Listing
February 2019

Women Leaders in Cardiac Transplantation.

Authors:
Sharon A Hunt

Circulation 2019 Feb;139(8):1005-1006

Division of Cardiovascular Medicine, Stanford University, Palo Alto, CA.

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http://dx.doi.org/10.1161/CIRCULATIONAHA.118.038631DOI Listing
February 2019

Cardiovascular Care in Women Veterans.

Circulation 2019 Feb;139(8):1102-1109

Division of Cardiology, Department of Medicine, Veterans Affairs Greater Los Angeles Healthcare System, CA (J.K.H., R.E.).

Cardiovascular disease is the number one cause of death for women in the United States. Of the 1.3 million active duty service members, 16. Read More

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http://dx.doi.org/10.1161/CIRCULATIONAHA.118.037748DOI Listing
February 2019

Women in Cardiology.

Circulation 2019 Feb;139(8):1001-1002

Monash Cardiovascular Research Centre, Monash University, Melbourne, Australia (S.Z.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.118.037835DOI Listing
February 2019

Cardiovascular Disease-Related Morbidity and Mortality in Women With a History of Pregnancy Complications.

Circulation 2019 Feb;139(8):1069-1079

Department of Epidemiology, Biostatisticcs and Occupational Health, McGill University, Montreal, QC, Canada (S.G., K.F., S.Y., H.A., C.D., R.P.).

Background: Women with a history of certain pregnancy complications are at higher risk for cardiovascular (CVD) disease. However, most clinical guidelines only recommend postpartum follow-up of those with a history of preeclampsia, gestational diabetes mellitus, or preterm birth. This systematic review was undertaken to determine if there is an association between a broader array of pregnancy complications and the future risk of CVD. Read More

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http://dx.doi.org/10.1161/CIRCULATIONAHA.118.036748DOI Listing
February 2019

CYP2C19 Genotype-Guided Antiplatelet Therapy and 30-Day Outcomes After Percutaneous Coronary Intervention.

Circ Genom Precis Med 2019 Feb;12(2):e002441

Division of Pharmacotherapy and Experimental Therapeutics, Eshelman School of Pharmacy (A.K.W., J.M., C.R.L.), School of Medicine, University of North Carolina at Chapel Hill.

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http://dx.doi.org/10.1161/CIRCGEN.119.002441DOI Listing
February 2019

Effect of Air Pollution and Hospital Admission: A Systematic Review.

Ann Glob Health 2018 Nov 5;84(4):670-678. Epub 2018 Nov 5.

Department of Community Health, National University of Malaysia, MY.

IntroductionMany epidemiological studies have demonstrated associations between air pollution levels and human health in terms of hospital admissions. The aim of this paper is to gather evidence concerning air pollution effects on the risk of hospital admission. We hypothesised that increase in: particulate matter (PM), ozone (O3), carbon monoxide (CO), nitrogen dioxide (NO2), and sulphur dioxide (SO2) levels would be associated with the increasing trend of hospital admission. Read More

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http://dx.doi.org/10.9204/aogh.2376DOI Listing
November 2018

Tobacco Use Worldwide: Legislative Efforts to Curb Consumption.

Ann Glob Health 2018 Nov 5;84(4):571-579. Epub 2018 Nov 5.

Ciberes, ES.

Tobacco smoking is recognized as a major preventable cause of disease worldwide and is linked to 6 million deaths annually, 30% of which are due to cancer. The negative health consequences of smoking currently represent one of the greatest public health challenges. Secondhand smoke, declared carcinogenic by the International Agency for Research on Cancer in 2004, is also a major source of morbidity and premature death in nonsmokers, particularly children. Read More

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http://dx.doi.org/10.9204/aogh.2362DOI Listing
November 2018

Platelet Flow Cytometry: Instrument Setup, Controls, and Panel Performance.

Cytometry B Clin Cytom 2019 Feb 19. Epub 2019 Feb 19.

Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, UK.

Platelet flow cytometry is widely used in cardiovascular medicine as the platelet surface is rich in clinical biomarkers. Surface profiling is critical in disease management, but current assays can abet clinical errors as they are suboptimal and prone to bias. Accordingly, the technical and analytical advances that can be used to create high quality assays with minimal error and maximal sensitivity were reviewed. Read More

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http://dx.doi.org/10.1002/cyto.b.21774DOI Listing
February 2019

Upregulation of miR-146a-5p is associated with increased proliferation and migration of vascular smooth muscle cells in aortic dissection.

J Clin Lab Anal 2019 Feb 19:e22843. Epub 2019 Feb 19.

Guangdong Cardiovascular Institute, Guangdong Provincial People' Hospital, Guangdong Academy of Medical Sciences, Guangdong, Guangzhou, China.

Background: This study aimed to investigate whether miR-146a-5p was involved in the pathogenesis of thoracic aortic dissection (AD) via regulating the biological function of vascular smooth muscle cells (VSMCs).

Methods: Circulating miR-146a-5p level was measured by quantitative polymerase chain reaction (qPCR) in AD patients and healthy controls. Human dissected aortic samples were obtained from patients with thoracic AD Stanford type A undergoing surgical repair, and normal control samples were from organ donors who died from nonvascular diseases. Read More

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http://dx.doi.org/10.1002/jcla.22843DOI Listing
February 2019
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