1,742,416 results match your criteria Cardiovascular surgery London England[Journal]


Graphene oxide induces cardiovascular defects in developing zebrafish (Danio rerio) embryo model: In-vivo toxicity assessment.

Sci Total Environ 2019 Apr 8;673:810-820. Epub 2019 Apr 8.

Center for Biofluid and Biomimic Research, Pohang University of Science and Technology (POSTECH), Pohang 37673, South Korea; Department of Mechanical Engineering, Pohang University of Science and Technology (POSTECH), Pohang 37673, South Korea. Electronic address:

Graphene oxide (GO) has wide engineering applications in various areas, including electronics, energy storage, pharmaceuticals, nanomedicine, environmental remediation and biotechnology, because of its unique physico-chemical properties. In the present study, the risk-related information of GO was evaluated to examine the potential ecological and health risks of developmental toxicity. Although the overall developmental toxicity of GO has been well characterized in zebrafish, however, its release effect at a certain concentration of living organisms with specific cardiovascular defects remains largely elusive. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00489697193160
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http://dx.doi.org/10.1016/j.scitotenv.2019.04.082DOI Listing
April 2019
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Multiscale modeling of the cardiovascular system for infants, children, and adolescents: Age-related alterations in cardiovascular parameters and hemodynamics.

Comput Biol Med 2019 Mar 23;108:200-212. Epub 2019 Mar 23.

Graduate School of Engineering, Chiba University, Inage, Chiba, Japan; Shanghai Jiao Tong University and Chiba University International Cooperative Research Center (SJTU-CU ICRC), Minhang District, Shanghai, China. Electronic address:

While zero- and one-dimensional multiscale modeling of the adult cardiovascular system (CVS) has been recognized as a useful tool in cardiovascular research and clinical applications, there are still not any generic cardiovascular models for a broad range of age groups. To study age-related alterations in cardiovascular parameters and hemodynamics, we here presented a versatile multiscale cardiovascular model considering the cardiovascular growth and development during aging. An adult cardiovascular model was first established by utilizing population-averaged physiological data. Read More

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http://dx.doi.org/10.1016/j.compbiomed.2019.03.021DOI Listing

Ranking of stroke and cardiovascular risk factors for an optimal risk calculator design: Logistic regression approach.

Comput Biol Med 2019 Mar 25;108:182-195. Epub 2019 Mar 25.

Stroke Monitoring and Diagnostic Division, AtheroPoint™, Roseville, CA, USA. Electronic address:

Purpose: Conventional cardiovascular risk factors (CCVRFs) and carotid ultrasound image-based phenotypes (CUSIP) are independently associated with long-term risk of cardiovascular (CV) disease. In this study, 26 cardiovascular risk (CVR) factors which consisted of a combination of CCVRFs and CUSIP together were ranked. Further, an optimal risk calculator using AtheroEdge composite risk score (AECRS1. Read More

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http://dx.doi.org/10.1016/j.compbiomed.2019.03.020DOI Listing

Imatinib-induced changes in the expression profile of microRNA in the plasma and heart of mice-A comparison with doxorubicin.

Biomed Pharmacother 2019 Apr 17;115:108883. Epub 2019 Apr 17.

Faculty of Pharmacy, Charles University, Heyrovského 1203, Hradec Králové, Czech Republic. Electronic address:

Cardiotoxicity is a serious adverse reaction to cancer chemotherapy and may lead to critical heart damage. Imatinib mesylate (IMB), a selective tyrosine kinase inhibitor, is sometimes accompanied by severe cardiovascular complications. To minimize risk, early biomarkers of such complications are of utmost importance. Read More

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http://dx.doi.org/10.1016/j.biopha.2019.108883DOI Listing

Cardiac arrest due to acute massive aortic root thrombosis after pericardial bioprosthetic aortic valve replacement.

Cardiovasc Pathol 2019 Apr 1;41:8-10. Epub 2019 Apr 1.

Cardiac Surgery Unit, Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padua, Padua, Italy.

Acute aortic root thrombosis extended to coronary ostia is a rare but potentially life-threatening complication of aortic valve replacement with bioprosthetic substitutes. We aimed to present the case of a 72-year-old woman with symptomatic rheumatic valve disease and associated atrial fibrillation who underwent conventional mitroaortic valve replacement with two stented bioprostheses (pericardial and porcine, respectively). Eight days after surgery, she had cardiac arrest due to ventricular fibrillation, requiring immediate cardiopulmonary resuscitation. Read More

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http://dx.doi.org/10.1016/j.carpath.2019.03.003DOI Listing

Trends and predictors of recurrent acute coronary syndrome hospitalizations and unplanned revascularization after index acute myocardial infarction treated with percutaneous coronary intervention.

Am Heart J 2019 Mar 5;212:134-143. Epub 2019 Mar 5.

Centre of Cardiovascular Research and Education in Therapeutics (CCRE), Monash University, Melbourne, Australia; Department of Cardiovascular Medicine, Alfred Hospital, Melbourne, Australia. Electronic address:

Background: Repeat hospitalizations for recurrent acute coronary syndrome (ACS) or unplanned revascularization after acute myocardial infarction (MI) are common, costly and potentially preventable. We aim to describe 10-year trends and identify independent risk factors of these repeat hospitalizations.

Methods: We analyzed data from 9615 patients from the Melbourne Interventional Group registry (2005-2014) who underwent percutaneous coronary intervention (PCI) for their index MI and survived to discharge. Read More

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http://dx.doi.org/10.1016/j.ahj.2019.02.013DOI Listing

Emodin improves glucose metabolism by targeting microRNA-20b in insulin-resistant skeletal muscle.

Phytomedicine 2018 Nov 16;59:152758. Epub 2018 Nov 16.

Department of Pharmacology (State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education), Harbin Medical University, Harbin 150081, China; Department of Pharmacology and Therapeutics, Melbourne School of Biomedical Sciences, Faculty of Medicine, Dentistry and Health Sciences, the University of Melbourne, Melbourne, 3010, Australia. Electronic address:

Background: Emerging evidence has indicated the therapeutic potential of emodin with its multiple pharmacological effects.

Purpose: To evaluate role of emodin in regulating insulin resistance (IR) and to elucidate the underlying molecular mechanisms.

Study Design/methods: Fasting blood glucose (FBG) and lipid levels were measured before and after intragastric administration of emodin in type 2 diabetes mellitus (T2DM) rats. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09447113183057
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http://dx.doi.org/10.1016/j.phymed.2018.11.018DOI Listing
November 2018
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An investigation of the detection capability of pulsed wave duplex Doppler of low grade stenosis using ultrasound contrast agent microbubbles - An in-vitro study.

Ultrasonics 2019 Apr 11;96:48-54. Epub 2019 Apr 11.

Medical Physics, Centre for Cardiovascular Science, University of Edinburgh, Edinburgh EH16 4TJ, UK.

Objective: The objective of the study was to investigate whether clinically used ultrasonic contrast agents improved the accuracy of spectral Doppler ultrasound in the detection of low grade (<50%) renal artery stenosis. Low grade stenoses in the renal artery are notoriously difficult to reliably detect using Doppler ultrasound due to difficulties such as overlying fat and bowel gas.

Methods: A range of anatomically-realistic renal artery phantoms with varying low degrees of stenosis (0, 30 and 50%) were constructed and peak velocity data was measured from within the pre-stenotic and mid-stenotic regions in each phantom, for both unenhanced and contrast-enhanced spectral Doppler data acquisitions. Read More

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http://dx.doi.org/10.1016/j.ultras.2019.04.003DOI Listing

The addition of silver affects the deformation mechanism of a twinning-induced plasticity steel: Potential for thinner degradable stents.

Acta Biomater 2019 Apr 17. Epub 2019 Apr 17.

Laboratory for Biomaterials and Bioengineering, Canada Research Chair I in Biomaterials and Bioengineering for the Innovation in Surgery, Department of Min-Met-Materials Engineering, Research Center of CHU de Quebec, Division of Regenerative Medicine, Laval University, Quebec City, QC G1V 0A6, Canada. Electronic address:

While Fe-based alloys have already been reported to possess all mechanical properties required for vascular stenting, their relatively low degradation rate in vivo still constitutes their main bottleneck. The inflammatory reaction generated by a stent is inversely proportional to its mass. Therefore, the tendency in stenting is to lower the section so to reduce the inflammatory reaction. Read More

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http://dx.doi.org/10.1016/j.actbio.2019.04.030DOI Listing

3D light-sheet assay assessing novel valproate-associated cardiotoxicity and folic acid relief in zebrafish embryogenesis.

Chemosphere 2019 Apr 11;227:551-560. Epub 2019 Apr 11.

Division of Biomedical Convergence, College of Biomedical Science, Kangwon National University, Chuncheon, South Korea. Electronic address:

Precise in vivo toxicological assays to determine the cardiotoxicity of pharmaceuticals and their waste products are essential in order to evaluate their risks to humans and the environment following industrial release. In the present study, we aimed to develop the sensitive imaging-based cardiotoxicity assay and combined 3D light-sheet microscopy with a zebrafish model to identify hidden cardiovascular anomalies induced by valproic acid (VPA) exposure. The zebrafish model is advantageous for this assessment because its embryos remain transparent. Read More

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http://dx.doi.org/10.1016/j.chemosphere.2019.04.061DOI Listing

Exploring relationships between cardiovascular activity and parental care behavior in nesting smallmouth bass: A field study using heart rate biologgers.

Comp Biochem Physiol A Mol Integr Physiol 2019 Apr 17. Epub 2019 Apr 17.

Fish Ecology and Conservation Physiology Laboratory, Department of Biology and Institute of Environmental and Interdisciplinary Science, Carleton University, Ottawa K1S 5B6, Canada.

Research in a variety of vertebrate taxa has found that cardiac function is a major limiting factor in the ability of animals to cope with physiological challenges, and thus is suggested to play an important role in mediating fitness-related behaviors in the wild. Yet, there remains a paucity of empirical assessments of the relationships between physiological performance and biological fitness in wild animals, partially due to challenges in measuring these metrics remotely. Using male smallmouth bass (Micropterus dolomieu) as a model, we tested for relationships between cardiac performance (measured using heart rate biologgers) and fitness-related behaviors (assessed using videography and snorkeler observations) in the wild during the parental care period. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10956433183027
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http://dx.doi.org/10.1016/j.cbpa.2019.04.012DOI Listing
April 2019
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Long term effects of chronic prenatal exposure to hypercarbia on organ growth and cardiovascular responses to adrenaline and hypoxia in common snapping turtles.

Comp Biochem Physiol A Mol Integr Physiol 2019 Apr 17. Epub 2019 Apr 17.

Department of Biological Sciences, Developmental Integrative Biology Cluster, University of North Texas, Denton, TX 76203-5220, USA. Electronic address:

Reptilian embryos often face challenging environmental gas compositions during incubation, which may inflict long lasting effects in the individuals' physiological responses. These conditions can have a lasting effect on the animal into juvenile life as chronic prenatal exposure to hypercarbia results in enlarged hatchling organ size, higher growth rate and resting metabolic rate, although relatively smaller increment in metabolic scope during digestion. Therefore, we wanted to verify whether prenatal hypercarbia exposure would cause persistent effects on morphology and physiological responses in C. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10956433193000
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http://dx.doi.org/10.1016/j.cbpa.2019.04.009DOI Listing
April 2019
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Effect of Implantation Site on Outcome of Tissue-Engineered Vascular Grafts.

Eur J Pharm Biopharm 2019 Apr 17. Epub 2019 Apr 17.

School of Pharmaceutical Sciences, University of Geneva, University of Lausanne, 1211 Geneva, Switzerland.

Objective: Vascular prostheses for small caliber bypass grafts in cardiac and vascular diseases or for access surgery are still missing. Poly (Ɛ-caprolactone) (PCL) has been previously investigated by our group and showed good biocompatibility and mechanical properties in vitro and rapid endothelialisation, cellular infiltration and vascularisation in vivo yielding optimal patency in the abdominal aortic position. The aim of the present study is to evaluate our PCL graft in the carotid position and to compare its outcome to the grafts implanted in the abdominal aortic position. Read More

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http://dx.doi.org/10.1016/j.ejpb.2019.04.012DOI Listing

Prognostic impact of worsening renal function in hospitalized heart failure patients with preserved ejection fraction -A report from the JASPER Registry.

J Card Fail 2019 Apr 17. Epub 2019 Apr 17.

Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan.

Background: The characteristics and prognostic impact of persistent worsening renal function (WRF, defined as an increase in serum creatinine >0.3 mg/dL during hospitalization) on heart failure with preserved ejection fraction (HFpEF) have not yet been fully examined.

Methods And Results: This was a post-hoc analysis of the Japanese Heart Failure Syndrome with Preserved Ejection Fraction (JASPER) registry. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10719164183116
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http://dx.doi.org/10.1016/j.cardfail.2019.04.009DOI Listing
April 2019
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Increased Risk of Death in First Year After Liver Transplantation Among Patients with Nonalcoholic Steatohepatitis vs Liver Disease of Other Etiologies.

Clin Gastroenterol Hepatol 2019 Apr 17. Epub 2019 Apr 17.

Gastroenterology, Henry Ford Hospital, Detroit, Michigan, United States.

Background & Aims: An increasing number of patients with non-alcoholic steatohepatitis (NASH) require liver transplantation. We compared outcomes of patients with liver diseases of different etiologies (NASH, hepatitis C virus [HCV]-associated liver disease, and alcohol-associated liver disease [ALD]).

Methods: We analyzed data from the United Network for Organ Sharing registry on 6344 patients who underwent liver transplantation for NASH, 17,037 for cirrhosis from chronic HCV infection, and 9279 for ALD. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15423565193042
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http://dx.doi.org/10.1016/j.cgh.2019.04.033DOI Listing
April 2019
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Cardioprotective effects of Aconiti Lateralis Radix Praeparata combined with Zingiberis Rhizoma on doxorubicin-induced chronic heart failure in rats and potential mechanisms.

J Ethnopharmacol 2019 Apr 17:111880. Epub 2019 Apr 17.

Department of Pharmacy, Fifth Medical Center, 302 Military Hospital of China, Beijing, 100039, China. Electronic address:

Background: The combined use of Aconiti Lateralis Radix Praeparata (ALRP) and Zingiberis Rhizoma (ZR) are classic compatibility in China for the treatment of cardiovascular diseases such as increasing myocardial contractility, anti-arrhythmia, reducing myocardial oxygen consumption, and dilating organ blood vessels, etc, thereby exerting anti-heart failure (HF) effects in traditional Chinese herbal medicine. However, comprehensive approaches for understanding the therapeutic effects and mechanisms underlying chronic heart failure (CHF) from the perspective of energy metabolism have not been pursued.

Aim: This research was aimed to investigate the effectiveness and potential mechanism of ALRP combined with ZR (1:1) on doxorubicin (DOX)-induced CHF in rats based on an integrated approach that combines network pharmacology analyses and molecular biology. Read More

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http://dx.doi.org/10.1016/j.jep.2019.111880DOI Listing
April 2019
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Osteopontin-derived synthetic peptide SVVYGLR has potent utility in the functional regeneration of oral and maxillofacial skeletal muscles.

Peptides 2019 Apr 17. Epub 2019 Apr 17.

The 1st Department of Oral and Maxillofacial Surgery, Graduate School of Dentistry, Osaka University, 1-8 Yamada-oka, Suita, Osaka, 565-0871, Japan. Electronic address:

Oral and maxillofacial skeletal muscles are critical for oral motor functions, and severe damage to these muscles by trauma or surgery may lead to persistent functional impairment. This study investigated the effects of SVVYGLR (SV) peptide, a thrombin-cleaved osteopontin-derived motif, on histopathological wound healing and functional repair after severe injury of skeletal muscles. A rat model of volumetric muscle loss bilateral masseter muscle was developed. Read More

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http://dx.doi.org/10.1016/j.peptides.2019.04.013DOI Listing

Standard complication screening information can be used for risk assessment for first time foot ulcer among patients with type 1 and type 2 diabetes.

Diabetes Res Clin Pract 2019 Apr 17. Epub 2019 Apr 17.

Steno Diabetes Center Copenhagen, Niels Steensensvej 2, 2820 Gentofte, Denmark; Department of Dermatology and Copenhagen Woundhealing Center, Copenhagen Wound Healing Center, Copenhagen University Hospital Bispebjerg, Bispebjerg Bakke 23, 2400 Copenhagen, Denmark.

Aim: Diabetic foot ulcer (DFU) is a major complication of both Type 1 Diabetes (T1D) and Type 2 Diabetes (T2D); however research into risk factors for DFU does not separate between these two types. The purpose of the present investigation was to identify risk factors for development of first time DFU (FTDFU) over a period of 15 years in patients with T1D and T2D separately.

Methods: This retrospective cohort study included 25220 feet from 5588 patients with T1D and 7113 patients with T2D treated in the period 2001 to 2015. Read More

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http://dx.doi.org/10.1016/j.diabres.2019.04.021DOI Listing

Cardiac syncope recurrence in type 2 diabetes mellitus patients vs. normoglycemics patients: the CARVAS study.

Diabetes Res Clin Pract 2019 Apr 17. Epub 2019 Apr 17.

Department of Advanced Medical and Surgical Sciences, University of Campania "Luigi Vanvitelli", Naples, Italy. Electronic address:

Study hypothesis cardiac autonomic dysfunction might lead to higher vaso vagal syncope (VVS) recurrence rate in type 2 diabetes mellitus (T2DM) patients vs. non diabetics patients.

Background: VVS recurrence might be due to alterations of autonomic system function, as assessed by heart rate variability (HRV). Read More

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http://dx.doi.org/10.1016/j.diabres.2019.04.015DOI Listing

NHCl treatment prevents doxorubicin-induced myocardial dysfunction in vivo.

Life Sci 2019 Apr 17. Epub 2019 Apr 17.

Department of Cardiology, First Affiliated Hospital of Dalian Medical University, Dalian 116011, China. Electronic address:

Aims: Improvements in cancer treatment have significantly extended the lifespan of patients. However, due to the adverse effects of cancer treatment, cancer survivors are at increased risk of cardiovascular complications. Doxorubicin is a widely used spectrum antitumor drug, but the life-threatening side-effect of cardiotoxicity limits its clinical application. Read More

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http://dx.doi.org/10.1016/j.lfs.2019.04.044DOI Listing

Astragaloside IV exerts angiogenesis and cardioprotection after myocardial infarction via regulating PTEN/PI3K/Akt signaling pathway.

Life Sci 2019 Apr 17. Epub 2019 Apr 17.

Jiangsu Province Hospital of Traditional Chinese Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China. Electronic address:

Aims And Methods: Acute myocardial infarction (AMI) is a common cardiovascular disease with high mortality. Astragaloside IV (AS-IV) was reported to have cardioprotective effect after AMI. We hypothesize that the cardioprotective role of AS-IV is exerted by enhancing angiogenesis via regulating PTEN/PI3K/Akt signaling pathway. Read More

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http://dx.doi.org/10.1016/j.lfs.2019.04.040DOI Listing
April 2019
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miR-27a promotes endothelial-mesenchymal transition in hypoxia-induced pulmonary arterial hypertension by suppressing BMP signaling.

Life Sci 2019 Apr 17. Epub 2019 Apr 17.

Department of Pharmacology, Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, Hunan 410078, China; Hunan Provincial Key Laboratory of Cardiovascular Research, Central South University, Changsha, Hunan 410078, China. Electronic address:

Aim: Growing evidence suggests that endothelial-mesenchymal transition (EndMT) play key roles in pulmonary arterial remodeling during pulmonary arterial hypertension (PAH), but the underlying mechanisms have yet to be fully understood. miR-27a has been shown to promote proliferation of pulmonary arterial cells during PAH, but its role in EndMT remains unexplored. This study was designed to investigate the role and underlying mechanism of miR-27a in EndMT during PAH. Read More

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http://dx.doi.org/10.1016/j.lfs.2019.04.038DOI Listing

Adjuvant Therapy for Patients with Early Large Cell Lung Neuroendocrine Cancer: A National Analysis.

Ann Thorac Surg 2019 Apr 17. Epub 2019 Apr 17.

Division of Cardiovascular and Thoracic Surgery, Department of Surgery, Duke University Medical Center.

Background: Current guidelines do not routinely recommend adjuvant therapy for resected stage I large cell lung neuroendocrine cancer (LCNEC). However, data regarding the role of adjuvant therapy in early LCNEC are limited. This National Cancer Database (NCDB) analysis was performed to improve the evidence guiding adjuvant therapy for early LCNEC. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00034975193056
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http://dx.doi.org/10.1016/j.athoracsur.2019.03.053DOI Listing
April 2019
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Robotic Assisted Lobectomy For Non-Small Cell Lung Cancer: A Comprehensive Institutional Experience.

Ann Thorac Surg 2019 Apr 17. Epub 2019 Apr 17.

Department of Thoracic and Cardiovascular Surgery, University of Texas MD Anderson Cancer Center, Houston, TX. Electronic address:

Background: It is unclear whether the enhanced dexterity and visualization of the surgical robot lessens morbidity and influences staging or survival. We compared outcomes of robotic-assisted lobectomy (RAL) with thoracoscopic (VAL) or open lobectomy (OL) of non-small cell lung cancer (NSCLC).

Methods: Using a prospective surgical database, perioperative and cancer related outcomes of patients who received a lobectomy for NSCLC from 2011-2017 were analyzed. Read More

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http://dx.doi.org/10.1016/j.athoracsur.2019.03.051DOI Listing

Endothelial B2-receptor overexpression as an alternative animal model for hereditary angioedema.

Allergy 2019 Apr 20. Epub 2019 Apr 20.

Max-Delbrück-Center for Molecular Medicine (MDC), Robert-Rössle-Strasse 10, 13125, Berlin, Germany.

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http://dx.doi.org/10.1111/all.13836DOI Listing

A novel angiotensin-I converting enzyme inhibitory peptide derived from the glutelin of vinegar soaked black soybean and its antihypertensive effect in spontaneously hypertensive rats.

J Biochem 2019 Apr 20. Epub 2019 Apr 20.

School of Life Science, Beijing University of Chinese Medicine, Beijing, China.

Vinegar soaked black soybean is a traditional Chinese food widely used for the treatment of hypertension. While its pharmacodynamic substance wasn't fully unveiled. It contained abundant glutelin, thus the purpose of this study was to obtain potent antihypertensive peptides from vinegar soaked black soybean. Read More

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https://academic.oup.com/jb/advance-article/doi/10.1093/jb/m
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http://dx.doi.org/10.1093/jb/mvz029DOI Listing
April 2019
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Syncope units: An emerging paradigm.

Pacing Clin Electrophysiol 2019 Apr 20. Epub 2019 Apr 20.

University of Wisconsin School of Medicine and Public Health, Department of Medicine.

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http://dx.doi.org/10.1111/pace.13701DOI Listing

Role of Leptin in the Association Between Body Adiposity and Persistent Asthma: A Longitudinal Study.

Obesity (Silver Spring) 2019 Apr 20. Epub 2019 Apr 20.

VIMA: Aging and Chronic Diseases, Epidemiological and Public Health Approaches, INSERM U1168, Villejuif, France.

Objective: Obesity is a likely risk factor for asthma. However, underlying mechanisms by which obesity affects asthma activity remain poorly understood. This study aimed to investigate the role of leptin, an adipocyte-derived proinflammatory protein, as a mediator in the association between body adiposity (assessed using BMI, waist circumference, and body fat percentage) and persistent asthma. Read More

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http://dx.doi.org/10.1002/oby.22466DOI Listing

Association of opioid receptor gene polymorphisms with drinking severity and impulsivity related to alcohol use disorder in a Korean population.

CNS Neurosci Ther 2019 Apr 19. Epub 2019 Apr 19.

Institute of Behavioral Science in Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea.

Aims: Recent evidence suggests that the opioid system is implicated in the pathophysiology of alcohol use disorder (AUD). We aimed to examine the genetic influence of opioid receptors on susceptibility to AUD and its clinical and psychological characteristics including harmful drinking behavior and various aspects of impulsivity in AUD patients.

Methods: Three μ-opioid receptor gene (OPRM1) variants and two κ-opioid receptor gene (OPRK1) variants were examined in 314 male patients with AUD and 324 male controls. Read More

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http://dx.doi.org/10.1111/cns.13138DOI Listing

Long noncoding RNA C2dat1 protects H9c2 cells against hypoxia injury by downregulating miR-22.

J Cell Physiol 2019 Apr 19. Epub 2019 Apr 19.

Department of Cardiology, Jilin Provincial Molecular Biology Research Center for Precision Medicine of Major Cardiovascular Disease, Jilin Provincial Cardiovascular Research Institute, China-Japan Union Hospital of Jilin University, Changchun, Jilin, China.

Myocardial ischemia is accompanied with hypoxia injury in myocardial cells. Long noncoding RNAs (lncRNA) CAMK2D-associated transcript 1 (C2dat1) C2dat1) has been linked with several ischemic diseases. However, the investigation regarding its role in myocardial ischemia is relatively rare. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/jcp.28667
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http://dx.doi.org/10.1002/jcp.28667DOI Listing
April 2019
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Evaluation of cardiovascular risk by growth-differentiation factor-15 and tissue Doppler imaging in children with subclinical hypothyroidism.

Endocrine 2019 Apr 19. Epub 2019 Apr 19.

Department of Biochemistry, Konya Training and Research Hospital, Konya, Turkey.

Objective: Subclinical hypothyroidism, defined as increased TSH serum levels and normal serum free T4 concentrations, has been associated with an increased risk of heart disease in adults. But, data in children and adolescents are scanty and treatment of subclinical hypothyroidism is controversial. Growth differentiation factor-15 (GDF-15) is a promising biomarker of cardiac remodeling. Read More

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http://dx.doi.org/10.1007/s12020-019-01933-wDOI Listing

De-escalation from ticagrelor to clopidogrel in acute coronary syndrome patients: a systematic review and meta-analysis.

J Thromb Thrombolysis 2019 Apr 19. Epub 2019 Apr 19.

Department of Cardiology, LMU München, Marchioninistraße 15, 81377, Munich, Germany.

De-escalation from ticagrelor to clopidogrel in acute coronary syndrome (ACS) may occur for a variety of reasons, including side effects (bleeding and non-bleeding) and costs. This study sought to assess the prevalence of de-escalation from ticagrelor to clopidogrel and the occurrence of adverse clinical outcomes following de-escalation. We conducted a systematic review of clinical trials and real-world studies in ACS patients treated with ticagrelor. Read More

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http://link.springer.com/10.1007/s11239-019-01860-7
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http://dx.doi.org/10.1007/s11239-019-01860-7DOI Listing
April 2019
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Acquired Von Willebrand Syndrome (AVWS) in cardiovascular disease: a state of the art review for clinicians.

J Thromb Thrombolysis 2019 Apr 19. Epub 2019 Apr 19.

Stonehill Professor of Medicine, University of Cincinnati College of Medicine, 231 Albert Sabin Way, CVC 4th Floor, Room 4936, Cincinnati, 45267, OH, USA.

Von Willebrand Factor (vWF) is a large glycoprotein with a broad range of physiological and pathological functions in health and disease. While vWF is critical for normal hemostasis, vascular integrity and repair, quantitative and qualitative abnormalities in the molecule can predispose to serious bleeding and thrombosis. The heritable form of von Willebrand Disease was first described nearly a century ago, but more recently, recognition of an acquired condition known as acquired von Willebrand Syndrome (AVWF) has emerged in persons with hematological, endocrine and cardiovascular diseases, disorders and conditions. Read More

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http://dx.doi.org/10.1007/s11239-019-01849-2DOI Listing

Novel insights of elevated systemic levels of bisphenol-A (BPA) linked to poor glycemic control, accelerated cellular senescence and insulin resistance in patients with type 2 diabetes.

Mol Cell Biochem 2019 Apr 20. Epub 2019 Apr 20.

Department of Cell and Molecular Biology, Madras Diabetes Research Foundation & Dr. Mohan's Diabetes Specialties Centre, ICMR-Centre for Advanced Research on Diabetes, Gopalapuram, Chennai, 600086, India.

There is a striking interaction of genes and environment in the etiology of type 2 diabetes mellitus (T2DM). While endocrine disrupting chemicals (EDCs) like bisphenol-A (BPA) have received special attention for their mechanistic role in metabolic disruption, there is a lack of clinically relevant data on BPA levels in Asian Indians, a population which is more susceptible to type 2 diabetes mellitus (T2DM) and cardiovascular diseases. Therefore, we measured systemic levels of BPA in patients with T2DM compared to individuals with normal glucose tolerance (n = 30 each). Read More

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http://dx.doi.org/10.1007/s11010-019-03540-9DOI Listing

Frailty index is associated with increased risk of elevated BNP in an elderly population: the Rugao Longevity and Ageing Study.

Aging Clin Exp Res 2019 Apr 19. Epub 2019 Apr 19.

State Key Laboratory of Genetic Engineering and MOE Key Laboratory of Contemporary Anthropology, School of Life Science and Institutes of Biomedical Sciences, Fudan University, Shanghai, China.

Background And Aims: To explore whether frailty, defined by frailty index (FI), is associated with the risk of elevated B-type natriuretic peptide (BNP), a surrogate endpoint of cardiovascular events.

Methods: Data of 1382 community-dwelling elders who had no documented cardiovascular diseases aged 70-84 years from the ageing arm of the Rugao Longevity and Ageing Study was used. Traditional risk factor index (TI) was constructed using eight established cardiovascular-related risk factors. Read More

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http://link.springer.com/10.1007/s40520-019-01189-4
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http://dx.doi.org/10.1007/s40520-019-01189-4DOI Listing
April 2019
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Cardiovascular Risk in Type 1 Diabetes Mellitus.

Diabetes Ther 2019 Apr 19. Epub 2019 Apr 19.

Cardiovascular Research Group, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, M13 9WU, UK.

Type 1 diabetes mellitus (T1DM) is associated with premature cardiovascular disease (CVD), but the underlying mechanisms remain poorly understood. The American Diabetes Association and the European Association for the Study of Diabetes recently updated their position statement on the management of type 2 diabetes mellitus (T2DM) to include additional focus on cardiovascular risk; improved management of risk factors in T1DM is also needed. There are important differences in the pathophysiology of CVD in T1DM and T2DM. Read More

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http://dx.doi.org/10.1007/s13300-019-0612-8DOI Listing

Longitudinal Impacts of Gastric Bypass Surgery on Pharmacodynamics and Pharmacokinetics of Statins.

Obes Surg 2019 Apr 19. Epub 2019 Apr 19.

Department of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, 4849 Calhoun Rd., Houston, TX, 77204, USA.

Purpose: Undergoing Roux-en-Y gastric bypass (RYGB) is expected to affect orally administered drug absorption. Statins are commonly prescribed to patients with obesity for the prevention of atherosclerotic cardiovascular diseases by lowering cholesterol. This is the first longitudinal prospective study on impacts of RYGB on weight loss, pharmacodynamics, and pharmacokinetics of atorvastatin, rosuvastatin, and simvastatin, and their active metabolites, up to 1-year post-surgery. Read More

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http://dx.doi.org/10.1007/s11695-019-03885-6DOI Listing

Cardiovascular Risk Assessment Varies Widely by Calculator and Race/Ethnicity in a Majority Latinx Cohort Living with HIV.

J Immigr Minor Health 2019 Apr 19. Epub 2019 Apr 19.

Research to Advance Community Health (ReACH) Center, UT Health San Antonio, San Antonio, TX, USA.

Comparison of cardiovascular disease (CVD) risk calculators in Latinx majority populations living with HIV can assist clinicians in selecting a calculator and interpreting results. 10-year CVD risks were estimated for 652 patients seen ≥ 2 times over 12 months in a public clinic using three risk calculators: Atherosclerotic CVD risk Calculator (ASCVD), Framingham Risk Calculator (FRC), and Data Collection on Adverse Effects of Anti-HIV Drugs Study (D:A:D) Calculator. Median estimated 10-year CVD risk in this population was highest using FRC (11%), followed by D:A:D (10%), and lowest with ASCVD (5%; p < 0. Read More

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http://dx.doi.org/10.1007/s10903-019-00890-wDOI Listing

Behavioral and Cardiovascular Effects of a Behavioral Weight Loss Program for People Living with HIV.

AIDS Behav 2019 Apr 19. Epub 2019 Apr 19.

Department of Psychiatry and Human Behavior, Alpert Medical School of Brown University and The Miriam Hospital, Providence, RI, USA.

We recently reported that a 12-week internet weight loss program produced greater weight losses than education control in overweight/obese people living with HIV (PLWH) (4.4 kg vs 1.0 kg; p < 0. Read More

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http://dx.doi.org/10.1007/s10461-019-02503-xDOI Listing

Spermine and gene methylation: a mechanism of lifespan extension induced by polyamine-rich diet.

Authors:
Kuniyasu Soda

Amino Acids 2019 Apr 19. Epub 2019 Apr 19.

Cardiovascular Research Institute, Saitama Medical Center, Jichi Medical University, 1-847 Amanuma, Omiya, Saitama-City, Saitama, Japan.

The polyamines spermidine and spermine are synthesized in almost all organisms and are also contained in food. Polyamine synthesis decreases with aging, but no significant decrease in polyamine concentrations were found in organs, tissues, and blood of adult animals and humans. We found that healthy dietary patterns were associated with a preference for polyamine-rich foods, and first reported that increased polyamine intake extended the lifespan of mice and decreased the incidence of colon cancer induced by repeated administration of moderate amounts of a carcinogen. Read More

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http://dx.doi.org/10.1007/s00726-019-02733-2DOI Listing

A high-affinity peptide substrate for G protein-coupled receptor kinase 2 (GRK2).

Amino Acids 2019 Apr 19. Epub 2019 Apr 19.

Division of Biopharmaceutics and Pharmacokinetics, National Cerebral and Cardiovascular Center Research Institute, 5-7-1 Fujishiro-dai, Suita, Osaka, 565-8565, Japan.

We synthesized a previously identified β-tubulin-derived G protein-coupled receptor kinase 2 (GKR2) peptide (GR-11-1; DEMEFTEAESNMN) and its amino-terminal extension (GR-11-1-N; GEGMDEMEFTEAESNMN) and carboxyl-terminal extension (GR-11-1-C; DEMEFTEAESNMNDLVSEYQ) peptides with the aim of finding a high-affinity peptide substrate for GRK2. GR-11-1-C showed high affinity for GRK2, but very low affinity for GKR5. Its specificity and sensitivity for GKR2 were greater than those of GR-11-1 and GR-11-1-N. Read More

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http://link.springer.com/10.1007/s00726-019-02735-0
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http://dx.doi.org/10.1007/s00726-019-02735-0DOI Listing
April 2019
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Association of body mass index with cardiac resynchronization therapy intention and left ventricular lead implantation failure: insights from the NCDR implantable cardioverter-defibrillator registry.

J Interv Card Electrophysiol 2019 Apr 19. Epub 2019 Apr 19.

Cardiac Electrophysiology Section, Division of Cardiology, Department of Medicine, University of California, San Diego, San Diego, CA, USA.

Background: Cardiac resynchronization therapy with defibrillator (CRT-D) implantation involves left ventricular (LV) lead placement for biventricular pacing and is more complex than implantable cardioverter-defibrillator (ICD)-only implantation. Differences in the prescription of CRT-D versus ICD may result from clinician biases based on patient body habitus, and body habitus may be associated with LV lead implantation failure.

Objective: We sought to evaluate whether patient body mass index (BMI) was associated with planned use and implantation failure of CRT-D therapy. Read More

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http://dx.doi.org/10.1007/s10840-019-00550-xDOI Listing

[Ga]Pentixafor PET/MR imaging of chemokine receptor 4 expression in the human carotid artery.

Eur J Nucl Med Mol Imaging 2019 Apr 19. Epub 2019 Apr 19.

Division of Nuclear Medicine, Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, Währinger Gürtel 18-20, 1090, Vienna, Austria.

Purpose: Type 4 chemokine receptor (CXCR4) plays an important role in immune cell migration during the atherosclerosis progression. We aimed to evaluate [Ga]Pentixafor positron emission tomography (PET) in combination magnetic resonance imaging (MRI) for in vivo quantification of CXCR4 expression in carotid plaques.

Methods: Seventy-two patients with lymphoma were prospectively scheduled for whole body [Ga]Pentixafor PET/MRI with an additional T2-weighted carotid sequence. Read More

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http://link.springer.com/10.1007/s00259-019-04322-7
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http://dx.doi.org/10.1007/s00259-019-04322-7DOI Listing
April 2019
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Peri-procedural complications in women: an alarming and consistent trend.

Eur Heart J 2019 Apr 19. Epub 2019 Apr 19.

Division of Cardiovascular Medicine, University of Utah School of Medicine, Salt Lake City, UT, USA.

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https://academic.oup.com/eurheartj/advance-article/doi/10.10
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http://dx.doi.org/10.1093/eurheartj/ehz193DOI Listing
April 2019
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Lung cancer survival and comorbidities in lung cancer screening participants of the Gdańsk screening cohort.

Eur J Public Health 2019 Apr 19. Epub 2019 Apr 19.

Department of Thoracic Surgery, Medical University of Gdańsk, Gdańsk, Poland.

Background: In 2010, the World Health Organisation recommended implementation of screening programmes in four groups of diseases-neoplasms, cardiovascular diseases (CVD), diabetes mellitus (DM) and chronic obstructive pulmonary disease (COPD). It is due to the fact that they share the same, modifiable risk factors.

Methods: Between 2009 and 2011, 8637 heavy smokers (aged 50-75, smoking history >20 pack-years) were screened in the Pomeranian Pilot Lung Cancer Screening Programme (PPP) in Gdańsk, Poland. Read More

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http://dx.doi.org/10.1093/eurpub/ckz052DOI Listing

Long-term results of atrial maze surgery in patients with congenital heart disease.

Europace 2019 Apr 19. Epub 2019 Apr 19.

Department of Cardiovascular Surgery, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.

Aims: Recurrent atrial tachycardia is common after repair of many types of congenital heart disease, and surgical ablation with a maze procedure represents a potential treatment strategy. The objective of this study is to report a single-centre 19 years' experience with maze surgery in congenital heart patients.

Methods And Results: Patients undergoing maze procedure concomitantly with cardiac surgical procedures were retrospectively analysed. Read More

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http://dx.doi.org/10.1093/europace/euz056DOI Listing

Lower carbohydrate diets and all-cause and cause-specific mortality: a population-based cohort study and pooling of prospective studies.

Eur Heart J 2019 Apr 19. Epub 2019 Apr 19.

Department of Hypertension, WAM University Hospital in Lodz, Medical University of Lodz, Zeromskiego 113, Lodz, Poland.

Aims: Little is known about the long-term association between low-carbohydrate diets (LCDs) and mortality. We evaluated the link between LCD and overall or cause-specific mortality using both individual data and pooled prospective studies.

Methods And Results: Data on diets from the National Health and Nutrition Examination Survey (NHANES; 1999-2010) were analysed. Read More

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https://academic.oup.com/eurheartj/advance-article/doi/10.10
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http://dx.doi.org/10.1093/eurheartj/ehz174DOI Listing
April 2019
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On the simulation of mitral valve function in health, disease, and treatment.

J Biomech Eng 2019 Apr 20. Epub 2019 Apr 20.

Gorman Cardiovascular Research Group, Department of Surgery, University of Pennsylvania, Philadelphia, PA.

The mitral valve (MV) is the heart valve that regulates blood ?ow between the left atrium and left ventricle (LV). In situations where the MV fails to fully cover the left atrioventricular ori?ce during systole, the resulting regurgitation causes pulmonary congestion, leading to heart failure and/or stroke. The causes of MV insuf?ciency can be either primary (e. Read More

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http://biomechanical.asmedigitalcollection.asme.org/article.
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http://dx.doi.org/10.1115/1.4043552DOI Listing
April 2019
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Protease-activated receptor 2 deficiency mediates cardiac fibrosis and diastolic dysfunction.

Eur Heart J 2019 Apr 19. Epub 2019 Apr 19.

Department of Cardiology, Charité Center 11, Charité-University Medicine Berlin, Hindenburgdamm 30, Berlin, Germany.

Aims: Heart failure with preserved ejection fraction (HFpEF) and pathological cardiac aging share a complex pathophysiology, including extracellular matrix remodelling (EMR). Protease-activated receptor 2 (PAR2) deficiency is associated with EMR. The roles of PAR1 and PAR2 have not been studied in HFpEF, age-dependent cardiac fibrosis, or diastolic dysfunction (DD). Read More

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https://academic.oup.com/eurheartj/advance-article/doi/10.10
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http://dx.doi.org/10.1093/eurheartj/ehz117DOI Listing
April 2019
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Retinal microvasculature and cerebral small vessel disease in the Lothian Birth Cohort 1936 and Mild Stroke Study.

Sci Rep 2019 Apr 19;9(1):6320. Epub 2019 Apr 19.

Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.

Research has suggested that the retinal vasculature may act as a surrogate marker for diseased cerebral vessels. Retinal vascular parameters were measured using Vessel Assessment and Measurement Platform for Images of the Retina (VAMPIRE) software in two cohorts: (i) community-dwelling older subjects of the Lothian Birth Cohort 1936 (n = 603); and (ii) patients with recent minor ischaemic stroke of the Mild Stroke Study (n = 155). Imaging markers of small vessel disease (SVD) (white matter hyperintensities [WMH] on structural MRI, visual scores and volume; perivascular spaces; lacunes and microbleeds), and vascular risk measures were assessed in both cohorts. Read More

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http://dx.doi.org/10.1038/s41598-019-42534-xDOI Listing
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