1,842,059 results match your criteria Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology[Journal]


Cardiovascular Biomarkers and Calculated Cardiovascular Risk in Orally Treated Type 2 Diabetes Patients: Is There a Link?

Horm Metab Res 2020 Jul 6. Epub 2020 Jul 6.

Department of Clinical Laboratory and Clinical Immunology, Central Clinical Laboratory, University Hospital "Alexandrovska", Medical University Sofia, Sofia, Bulgaria.

The aim of the study was to test the correlation of serum levels of asymmetric dimethylarginine (ADMA), endothelin 1 (ET-1), N-terminal brain natriuretic pro-peptide (NT-proBNP), and placental growth factor (PIGF-1) with estimated cardiovascular (CV) risk. The study group was composed of 102 women and 67 men with type 2 diabetes, having their glycemic and metabolic parameters assessed. All were on oral antidiabetic drugs. Read More

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http://dx.doi.org/10.1055/a-1199-2378DOI Listing

Outcome of Very Low and Low Birth Weight Infants with Esophageal Atresia: Results of the Turkish Esophageal Atresia Registry.

Eur J Pediatr Surg 2020 Jul 6. Epub 2020 Jul 6.

Department of Pediatric Surgery, Sisli Hamidiye Etfal Education and Research Hospital, Istanbul, Turkey.

Introduction:  The data of the Turkish Esophageal Atresia Registry (TEAR) was evaluated to define the outcome of very low birth weight (VLBW) and low BW (LWB) infants with esophageal atresia (EA).

Materials And Methods:  The data registered by 24 centers between 2014 and 2018 were evaluated for demographic features, prenatal findings, associated anomalies, surgical treatment, and outcome. Patients were enrolled in three groups according to their BWs (VLBW <1,500 g), LWB = 1,500-2,500 g), and normal BW (NBW; >2,500 g). Read More

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http://dx.doi.org/10.1055/s-0040-1713663DOI Listing

Silencing of long non-coding RNA Sox2ot inhibits oxidative stress and inflammation of vascular smooth muscle cells in abdominal aortic aneurysm via microRNA-145-mediated Egr1 inhibition.

Aging (Albany NY) 2020 Jul 6;12. Epub 2020 Jul 6.

Department of Cardiovascular Surgery, Provincial Clinical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou 350001, P.R. China.

Long non-coding RNAs (lncRNAs) have been largely reported to contribute to the development and progression of abdominal aortic aneurysm (AAA), a common vascular degenerative disease. The present study was set out with the aim to investigate the possible role of lncRNA Sox2ot in the development of AAA. In this study, we found that lncRNA Sox2ot and early growth response factor-1 (Egr1) were highly expressed, while microRNA (miR)-145 was poorly expressed in Ang II-induced AAA mice and oxidative stress-provoked vascular smooth muscle cell (VSMC) model. Read More

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http://dx.doi.org/10.18632/aging.103077DOI Listing

Associations of skeletal muscle mass with atherosclerosis and inflammatory markers in Korean adults.

Arch Gerontol Geriatr 2020 Jun 24;90:104163. Epub 2020 Jun 24.

Department of Family Medicine, St. Vincent's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea. Electronic address:

Background: Several global studies have clarified the relationship of sarcopenia with inflammatory markers and atherosclerosis; however, these associations in Korean adults remain unclear. We evaluated whether low skeletal muscle mass is associated with atherosclerosis and inflammatory markers in Korean adults.

Methods: We analysed data from 1556 Korean adults who visited a Health Promotion Centre in South Korea. Read More

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http://dx.doi.org/10.1016/j.archger.2020.104163DOI Listing

Readmission and Resource Use After Robotic-assisted versus Open Pancreaticoduodenectomy: 2010-2017.

J Surg Res 2020 Jul 3;255:517-524. Epub 2020 Jul 3.

Department of Surgery, University of California Los Angeles, Los Angeles, California. Electronic address:

Background: Unplanned rehospitalization is considered an adverse quality of care indicator. Minimally invasive operations carry the potential to reduce resource use while enhancing recovery. Robotic-assisted pancreaticoduodenectomy (RAPD) has been used to improve outcomes of its morbid open counterpart. Read More

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http://dx.doi.org/10.1016/j.jss.2020.05.084DOI Listing

Hospital mortality in decompensated heart failure. A pilot study.

J Electrocardiol 2020 May 12;61:147-152. Epub 2020 May 12.

Dipartimento di Medicina Clinica e Molecolare, S. Andrea Hospital, "Sapienza" University of Rome, Via di Grottarossa 1035/1039, k00189 Rome, Italy.

Background/aim: Heart failure is a leading cause of morbidity and mortality worldwide and it is a major cause of emergency department access for cardiovascular disease patients. Aim of this study was to identify the electrocardiographic (ECG) markers, based on short-term temporal repolarization dispersion, capable to individuate decompensated chronic heart failure (CHF) patients at high mortality risk.

Methods: We obtained the following variables from an ECG recording, monitored via mobile phone, during 5-minute recordings in decompensated CHF patients: RR, QT end (QTe), QT peak (QTp) and T peak to T end (Te) and we calculated mean, standard deviation () and normalized index (N). Read More

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http://dx.doi.org/10.1016/j.jelectrocard.2020.05.006DOI Listing

Transcatheter InterAtrial Shunt Device for the treatment of heart failure: Rationale and design of the pivotal randomized trial to REDUCE Elevated Left Atrial Pressure in Patients with Heart Failure II (REDUCE LAP-HF II).

Am Heart J 2019 Nov 11;226:222-231. Epub 2019 Nov 11.

Northwestern University Feinberg School of Medicine, Chicago, IL. Electronic address:

Background: A randomized, sham-controlled trial in patients with heart failure (HF) and left ventricular ejection fraction (LVEF) ≥40% demonstrated reductions in pulmonary capillary wedge pressure (PCWP) with a novel transcatheter InterAtrial Shunt Device (IASD). Whether this hemodynamic effect will translate to an improvement in cardiovascular outcomes and symptoms requires additional study.

Study Design And Objectives: REDUCE Elevated Left Atrial Pressure in Patients with Heart Failure II (REDUCE LAP HF-II) is a multicenter, prospective, randomized, sham-controlled, blinded trial designed to evaluate the clinical efficacy of the IASD in symptomatic HF and elevated left atrial pressures. Read More

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http://dx.doi.org/10.1016/j.ahj.2019.10.015DOI Listing
November 2019

A systematic review on the association between obstructive sleep apnea and chronic kidney disease.

Sleep Med Rev 2020 May 18;53:101337. Epub 2020 May 18.

Department of Clinical, Internal, Anesthetic and Cardiovascular Sciences, Sapienza University of Rome, Rome, Italy.

This systematic review aims to provide a more comprehensive overview of the association between obstructive sleep apnea (OSA) and chronic kidney disease (CKD). A PubMed search was conducted using the terms "(obstructive sleep disorders OR obstructive sleep apnea OR obstructive sleep apnea syndrome) AND (kidney function OR renal outcome OR chronic kidney disease OR end stage renal disease)". Four hundred seventy four articles were initially retrieved, 227 in the last five years. Read More

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http://dx.doi.org/10.1016/j.smrv.2020.101337DOI Listing

Autonomic and cardiovascular consequences resulting from experimental hemorrhagic stroke in the left or right intermediate insular cortex in rats.

Auton Neurosci 2020 Jun 24;227:102695. Epub 2020 Jun 24.

Departamento de Fisiologia & Biofísica, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil. Electronic address:

Damage to the insular cortex (IC) results in serious cardiovascular consequences and evidence indicates that the characteristics are lateralized. However, a study comparing the effects of focal experimental hemorrhage between IC sides was never performed. We compared the cardiovascular, autonomic and cardiac changes produced by focal experimental hemorrhage (ICH) into the left (L) or right (R) IC. Read More

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http://dx.doi.org/10.1016/j.autneu.2020.102695DOI Listing

Upregulation of miR-200c-3p induced by NaF promotes endothelial apoptosis by activating Fas pathway.

Environ Pollut 2020 Jun 26;266(Pt 1):115089. Epub 2020 Jun 26.

Center for Endemic Disease Control, Chinese Center for Disease Control and Prevention, Harbin Medical University, Harbin, 150081, Heilongjiang Province, China; Key Lab of Etiology and Epidemiology, Education Bureau of Heilongjiang Province & Ministry of Health (23618504), Harbin Medical University, Harbin, 150081, Heilongjiang Province, China; Institution of Environmentally Related Diseases, Harbin Medical University, Harbin, Heilongjiang Province, China. Electronic address:

Fluoride has been considered as a risk factor of cardiovascular disease due to its endothelial toxicology. However, the mechanism underlying the endothelial toxicity of fluoride has not been clearly illustrated. MiR-200c-3p was strongly linked with endothelial function and its level is increased in serum of fluorosis patients, but it is unclear the role of miR-200c-3p in the fluoride induced endothelial dysfunction. Read More

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http://dx.doi.org/10.1016/j.envpol.2020.115089DOI Listing

A systematic review of LDLR, PCSK9, and APOB variants in Asia.

Atherosclerosis 2020 May 20;305:50-57. Epub 2020 May 20.

Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran; Growth and Development Research Center, Tehran University of Medical Sciences, Tehran, Iran. Electronic address:

Background And Aims: Genetic identification is a public health care concern for management of familial hypercholesterolemia (FH) associated cardiovascular morbidity and mortality. This study presents the spectrum and distribution of LDLR, APOB, PCSK9 gene mutations in Asia.

Methods: Databases were searched for English papers from 1950 to 2019. Read More

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http://dx.doi.org/10.1016/j.atherosclerosis.2020.05.004DOI Listing

Carotid intima-media thickness and subclinical left heart dysfunction in the general population.

Atherosclerosis 2020 Jun 15;305:42-49. Epub 2020 Jun 15.

Department of Cardiovascular Medicine, The University of Tokyo, Tokyo, Japan.

Background And Aims: Although carotid intima-media thickness (IMT) is an established marker of atherosclerosis and carries independent risk for cardiovascular disease, its possible association with subclinical cardiac dysfunction has not been extensively evaluated. Left ventricular global longitudinal strain (LVGLS) and peak left atrial longitudinal systolic strain (PALS) can detect subclinical left heart dysfunction. This study aimed to investigate the association between carotid IMT and subclinical left heart dysfunction in a sample of the general population without overt cardiac disease. Read More

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http://dx.doi.org/10.1016/j.atherosclerosis.2020.05.019DOI Listing

Integration of mechanical conditioning into a high throughput contractility assay for cardiac safety assessment.

J Pharmacol Toxicol Methods 2020 Jul 3:106892. Epub 2020 Jul 3.

Nanion Technologies GmbH, Ganghoferstr 70A, 80339 Munich, Germany.

Induction Despite increasing acceptance of human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) in safety pharmacology, controversy remains about the physiological relevance of existing in vitro models for their mechanical testing. We hypothesize that existing signs of immaturity of the cell models result from an improper mechanical environment. With the presented study, we aimed at validating the newly developed FLEXcyte96 technology with respect to physiological responses of hiPSC-CMs to pharmacological compounds with known inotropic and/or cardiotoxic effects. Read More

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http://dx.doi.org/10.1016/j.vascn.2020.106892DOI Listing

Inotropic Assessment in Engineered 3D Cardiac Tissues using Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes in the Biowire II Platform.

J Pharmacol Toxicol Methods 2020 Jul 3:106886. Epub 2020 Jul 3.

Amgen Research, Translational Safety & Bioanalytical Sciences, Thousand Oaks, CA, USA.

To develop therapeutics for cardiovascular disease, especially heart failure, translational models for assessing cardiac contractility are necessary for preclinical target validation and lead optimization. The availability of stem cell-derived cardiomyocytes (SC-CM) has generated a great opportunity in developing new in-vitro models for assessing cardiac contractility. However, the immature phenotype of SC-CM is a well-recognized limitation in inotropic evaluation, especially regarding the lack of or diminished positive inotropic response to β-adrenergic agonists. Read More

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http://dx.doi.org/10.1016/j.vascn.2020.106886DOI Listing

Lean Americans With Nonalcoholic Fatty Liver Disease Have Lower Rates of Cirrhosis and Co-morbid Diseases.

Clin Gastroenterol Hepatol 2020 Jul 3. Epub 2020 Jul 3.

University of Michigan, Ann Arbor, MI. Electronic address:

Background & Aims: Nonalcoholic fatty liver disease (NAFLD) is typically associated with obesity. Little is known about the prevalence of cirrhosis in patients with NAFLD and a normal body mass index (BMI).

Methods: We determined prevalence of cirrhosis, cardiovascular disease (CVD), and metabolic abnormalities among participants in all BMI categories in the TARGET-NASH study. Read More

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http://dx.doi.org/10.1016/j.cgh.2020.06.066DOI Listing

Accuracy of contrast-enhanced computed tomography for thrombus detection prior to atrial fibrillation ablation and role of novel Left Atrial Appendage Enhancement Index in appendage flow assessment.

Int J Cardiol 2020 Jul 3. Epub 2020 Jul 3.

Division of Cardiovascular Medicine, The Ohio State University Wexner Medical Center, Columbus, OH, USA. Electronic address:

Aims: To evaluate diagnostic accuracy of different protocols of contrast enhanced computed tomography venogram (CTV) for LAA thrombus detection in patients undergoing AF ablation and study the correlation of the novel LAA enhancement index (LAA-EI) to LAA flow velocity obtained using transesophageal echocardiography (TEE).

Methods: Study comprised of patients undergoing CTV and TEE on the same day from October 2016 to December 2017. Three CTV scanning protocols (described in results), were evaluated wherein ECG gating was used only for those with sinus rhythm on day of CTV. Read More

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http://dx.doi.org/10.1016/j.ijcard.2020.06.035DOI Listing

Parkinson's disease a futile entangle of Mankind's credence on an herbal remedy: A review.

Life Sci 2020 Jul 3:118019. Epub 2020 Jul 3.

Cardiovascular and Mitochondrial Related Disease Research Center, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan; Graduate Institute of Biomedical Sciences, China Medical University, Taichung 404, Taiwan; Center of General Education, Buddhist Tzu Chi Medical Foundation, Tzu Chi University of Science and Technology, Hualien 970, Taiwan; Department of Medical Research, China Medical University Hospital, China Medical University, Taichung 404, Taiwan; Department of Biotechnology, Asia University, Taichung 413, Taiwan. Electronic address:

Parkinson's disease (PD) is a disease of the human nervous system with an onset, in the sixth and seventh decades of the human life. Chiefly perceived as progressive degeneration of dopaminergic (DA) neurons in the substantia nigra pars compacta (SNpc) with the ensued loss of dopamine in the striatum and the presence of Lewy bodies, consisting of α-synuclein agglomeration. In which the neuronal bridge between substantia nigra and striatum plays an advent role in the motor system. Read More

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http://dx.doi.org/10.1016/j.lfs.2020.118019DOI Listing

Chronic stimulation of the sigma-1 receptor ameliorates ventricular ionic and structural remodeling in a rodent model of depression.

Life Sci 2020 Jul 3:118047. Epub 2020 Jul 3.

Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan 430060, PR China; Cardiovascular Research Institute, Wuhan University, Wuhan 430060, PR China; Hubei Key Laboratory of Cardiology, Wuhan 430060, PR China. Electronic address:

Aim: The purpose of the study was to investigate what effects the sigma-1 receptor (S1R) could exert on the cardiac myocyte ion channels in a rodent model of depression and to explore the underlying mechanisms since depression is an independent risk factor for cardiovascular diseases including ventricular arrhythmias (VAs).

Materials And Methods: To establish the depression model in rats, chronic mild unpredictable stress (CMUS) for 28 days was used. The S1R agonist fluvoxamine was injected intraperitoneally from the second week to the last week for 21 days in total, and the effects were evaluated by patch clamp, western blot analysis, and Masson staining. Read More

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http://dx.doi.org/10.1016/j.lfs.2020.118047DOI Listing

circPAN3 exerts a profibrotic role via sponging miR-221 through FoxO3/ATG7-activated autophagy in a rat model of myocardial infarction.

Life Sci 2020 Jul 3:118015. Epub 2020 Jul 3.

Department of Cardiology, Xiangya Hospital, Central South University, Changsha 410008, PR China. Electronic address:

Background: Cardiovascular disease (CVD) is the leading cause of mortality worldwide. Cardiac fibrosis is the scarring process occurs commonly with CVDs impairing the function and structure of heart. Herein, we investigated the role of circPAN3 in the pathogenesis of cardiac fibrosis. Read More

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http://dx.doi.org/10.1016/j.lfs.2020.118015DOI Listing

Association of systemic inflammatory biomarkers with morphological characteristics of the coronary atherosclerotic plaque by intravascular optical coherence tomography.

Hellenic J Cardiol 2020 Jul 3. Epub 2020 Jul 3.

UCL Institute of cardiovascular science, London, UK; Royal Free Hospital, London , UK.

Despite significant advances in preventive, medical and interventional management, coronary artery disease remains the leading cause of death worldwide. We now know that in the majority of acute coronary syndromes, a thrombotic event is triggered either by the rupture or erosion of the so-called high-risk or 'vulnerable' plaque. However, accurately identifying the individual who is at significant risk of acute event remains the holy grail of preventive cardiology. Read More

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http://dx.doi.org/10.1016/j.hjc.2020.06.008DOI Listing

Living in a Food Desert is Associated with 30-day Readmission After Revascularization for Chronic Limb-Threatening Ischemia.

Ann Vasc Surg 2020 Jul 3. Epub 2020 Jul 3.

Department of Surgery, University of California, San Francisco, San Francisco, CA. Electronic address:

Objective: Living in a Food Desert has been associated with increased cardiovascular risk; however, its impact on vascular surgery outcomes is unknown. This study hypothesized that living in a Food Desert would be associated with increased postoperative complications in patients undergoing revascularization for chronic limb-threatening ischemia (CLTI).

Methods: This was a single-center retrospective analysis of open and endovascular infrainguinal revascularization for CLTI between April 2013 and December 2015. Read More

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http://dx.doi.org/10.1016/j.avsg.2020.06.052DOI Listing

Links between Child and Adolescent Psychiatric Disorders and Cardiovascular Risk.

Can J Cardiol 2020 Jul 3. Epub 2020 Jul 3.

Department of Psychiatry, Hospital for Sick Children Department of Psychiatry, Faculty of Medicine, University of Toronto.

This narrative review, emphasizing children and adolescents, addresses the link between five psychiatric disorders and cardiovascular risk: attention deficit hyperactivity disorder (ADHD), autism spectrum disorders, anxiety disorders, depression, and bipolar disorders. The evidence regarding cardiovascular risk factors, non-invasive measures of early atherosclerosis, and cardiovascular disease prevalence and/or mortality is summarized. Whereas multiple studies have examined stimulant treatment of ADHD in relation to cardiovascular death, and autonomic-vagal function in autism spectrum disorders, little is known regarding atherosclerotic cardiovascular disease in these conditions. Read More

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http://dx.doi.org/10.1016/j.cjca.2020.06.023DOI Listing

Aerobic capacity modulates adaptive thermogenesis: Contribution of non-resting energy expenditure.

Physiol Behav 2020 Jul 3:113048. Epub 2020 Jul 3.

Department of Biological Sciences; School of Biomedical Sciences, Kent State University, Kent, Ohio, USA.

Decreases in energy stores requires negative energy balance where caloric expenditure exceeds energy intake, which can induce adaptive thermogenesisࣧthe reduction of energy expenditure (EE) beyond that accounted for by the weight lost. Adaptive thermogenesis varies between individuals. The component of total daily EE responsible for the interindividual variation in adaptive thermogenesis was investigated in this study, using a rat model that differs in obesity propensity and physical activity. Read More

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http://dx.doi.org/10.1016/j.physbeh.2020.113048DOI Listing

Legacy effect of intensive glucose control on major adverse cardiovascular outcome: systematic review and meta-analyses of trials according to different scenarios.

Metabolism 2020 Jul 3:154308. Epub 2020 Jul 3.

IRCCS MultiMedica, Milan, Italy. Electronic address:

Background: Early and intensive glycaemic control provides long-term protection against the development of microvascular complications, a phenomenon defined legacy effect. Whether a legacy effect of high glucose exists also on macrovascular endpoints is uncertain.

Methods And Findings: We performed a systematic review of both randomized clinical trials (RCT)s and observational studies pertinent to the research question. Read More

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http://dx.doi.org/10.1016/j.metabol.2020.154308DOI Listing

Integrin α5 and Integrin α4 cooperate to promote endocardial differentiation and heart morphogenesis.

Dev Biol 2020 Jul 3. Epub 2020 Jul 3.

Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA. Electronic address:

Endocardium is critically important for proper function of the cardiovascular system. Not only does endocardium connect the heart to blood vasculature, it also plays an important role in heart morphogenesis, valve formation, and ventricular trabeculation. The extracellular protein Fibronectin (Fn1) promotes endocardial differentiation, but the signaling pathways downstream of Fn1 that regulate endocardial development are not understood. Read More

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http://dx.doi.org/10.1016/j.ydbio.2020.06.006DOI Listing

β-estradiol adjusts intestinal function via ERβ and GPR30 mediated PI3K/AKT signaling activation to alleviate postmenopausal dyslipidemia.

Biochem Pharmacol 2020 Jul 3:114134. Epub 2020 Jul 3.

School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China; Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China. Electronic address:

Decreases in estrogen secretion and estrogen receptor function lead to an increase in the incidence of dyslipidemia and cardiovascular disease (CVD) in postmenopausal women. We previously reported that β-estradiol has a significant regulatory effect on lipids in ApoE mice with bilateral ovariectomy. In the present study, we investigated how β-estradiol regulates intestinal function via estrogen receptors to alleviate postmenopausal dyslipidemia. Read More

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http://dx.doi.org/10.1016/j.bcp.2020.114134DOI Listing

The Rise of Open-Sourced Machine Learning in Small and Imbalanced Datasets: Predicting In-Stent Restenosis.

Can J Cardiol 2020 Feb 8. Epub 2020 Feb 8.

Division of Cardiology and Cardiovascular Research Institute, Cardiology, Department of Medicine, University of California, San Francisco, California, USA; Bakar Computational Health Sciences Institute, University of California, San Francisco, California, USA.

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http://dx.doi.org/10.1016/j.cjca.2020.02.002DOI Listing
February 2020

High-Sensitivity Cardiac Troponin for the Exclusion of Inducible Myocardial Ischemia in Symptomatic Patients.

Ann Intern Med 2020 Jul;173(1):77

Cardiovascular Research Institute Basel, University Hospital Basel, and University of Basel, Basel, Switzerland (J.W., C.M.).

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http://dx.doi.org/10.7326/L20-0261DOI Listing

Artificial Intelligence and Machine Learning in Arrhythmias and Cardiac Electrophysiology.

Circ Arrhythm Electrophysiol 2020 Jul 6. Epub 2020 Jul 6.

Division of Cardiovascular Medicine, Stanford University, Stanford & Veterans Affairs Palo Alto Health Care System, Palo Alto, CA.

Artificial intelligence (AI) and machine learning (ML) in medicine are currently areas of intense exploration, showing potential to automate human tasks and even perform tasks beyond human capabilities. Literacy and understanding of AI/ML methods are becoming increasingly important to researchers and clinicians. The first objective of this review is to provide the novice reader with literacy of AI/ML methods and provide a foundation for how one might conduct an ML study. Read More

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http://dx.doi.org/10.1161/CIRCEP.119.007952DOI Listing

Increased Platelet Aggregation in Children and Adolescents with Sleep Disordered Breathing.

Am J Respir Crit Care Med 2020 Jul 6. Epub 2020 Jul 6.

Women's and Children's Hospital Adelaide, 6053, Respiratory and sleep Medicine, Adelaide, South Australia, Australia.

Objective: Sleep disordered breathing (SDB) is associated with increased vascular resistance in children and adults. Persistent increased vascular resistance damages vascular endothelial cells-a marker of which is increased platelet activation. This study compared whole blood impedance platelet aggregation in children diagnosed clinically as SDB warranting adenotonsillectomy and healthy controls. Read More

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http://dx.doi.org/10.1164/rccm.201911-2229OCDOI Listing

The Geometry of the roots of the Brachial Plexus.

J Anat 2020 Jul 6. Epub 2020 Jul 6.

Leeds Institute for Medical Research, University of Leeds, Leeds, UK.

Diffusion tensor magnetic resonance imaging (DTI) can be used to reconstruct the brachial plexus in 3D via tracts connecting contiguous diffusion tensors with similar primary eigenvector orientations. When creating DTI tractograms, the turning angle of connecting lines (step angle) must be prescribed by the user; however, the literature is lacking detailed geometry of brachial plexus to inform such decisions. Therefore, the spinal cord and brachial plexus of 10 embalmed adult cadavers were exposed bilaterally by posterior dissection. Read More

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http://dx.doi.org/10.1111/joa.13270DOI Listing

Evaluating use cases for human challenge trials in accelerating SARS-CoV-2 vaccine development.

Clin Infect Dis 2020 Jul 6. Epub 2020 Jul 6.

Waitlist Zero, Brooklyn, NY, United States.

Human challenge trials (HCTs) have been proposed as a means to accelerate SARS-CoV-2 vaccine development. We identify and discuss three potential use cases of HCTs in the current pandemic: evaluating efficacy, converging on correlates of protection, and improving understanding of pathogenesis and the human immune response. We outline the limitations of HCTs and find that HCTs are likely to be most useful for vaccine candidates currently in preclinical stages of development. Read More

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http://dx.doi.org/10.1093/cid/ciaa935DOI Listing

Subclinical anthracycline therapy-related cardiac Dysfunction: an ignored stage B heart failure in an African population.

Cardiovasc J Afr 2020 Jun 24;31:1-5. Epub 2020 Jun 24.

Hatter Institute for Cardiovascular Research in Africa, University of Cape Town, Cape Town, South Africa.

Anthracyclines are potent antineoplastic agents with a proven efficacy in the treatment of many paediatric and adult haematological and solid-organ cancers. Anthracycline therapy-related cardiac dysfunction (ATRCD) is the commonest and most well-studied chemotherapy-induced cardiovascular toxicity. Therefore patients who received anthracycline therapy are considered in stage A heart failure. Read More

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http://dx.doi.org/10.5830/CVJA-2020-013DOI Listing

Effect of invasive strategy on long-term mortality in elderly patients presenting with acute coronary syndrome.

Cardiovasc J Afr 2020 Jun 22;31:1-5. Epub 2020 Jun 22.

Cardiology Department, Pamukkale University Hospitals, Pamukkale, Denizli, Turkey.

Objective: The elderly have the highest incidence of cardiovascular disease and frequently present with acute coronary syndrome (ACS). In this study, our aim was to evaluate the effect of an invasive strategy on long-term mortality in patients of 80 years and older presenting with ACS.

Methods: Patients who were admitted to hospital with ACS were recruited using appropriate ICD codes in the computerised hospital data system. Read More

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http://dx.doi.org/10.5830/CVJA-2020-011DOI Listing

Clinical interpretation of variants identified in RNU4ATAC, a non-coding spliceosomal gene.

PLoS One 2020 6;15(7):e0235655. Epub 2020 Jul 6.

Equipe GENDEV, Centre de Recherche en Neurosciences de Lyon, Inserm U1028, CNRS UMR5292, Université Lyon 1, Université St Etienne, Lyon, France.

Biallelic variants in RNU4ATAC, a non-coding gene transcribed into the minor spliceosome component U4atac snRNA, are responsible for three rare recessive developmental diseases, namely Taybi-Linder/MOPD1, Roifman and Lowry-Wood syndromes. Next-generation sequencing of clinically heterogeneous cohorts (children with either a suspected genetic disorder or a congenital microcephaly) recently identified mutations in this gene, illustrating how profoundly these technologies are modifying genetic testing and assessment. As RNU4ATAC has a single non-coding exon, the bioinformatic prediction algorithms assessing the effect of sequence variants on splicing or protein function are irrelevant, which makes variant interpretation challenging to molecular diagnostic laboratories. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0235655PLOS

Effect of methotrexate use on the development of type 2 diabetes in rheumatoid arthritis patients: A systematic review and meta-analysis.

Authors:
Leena R Baghdadi

PLoS One 2020 6;15(7):e0235637. Epub 2020 Jul 6.

Department of Family and Community Medicine, College of Medicine, King Saud University, Riyadh, Saudi Arabia.

Background: The high risk of cardiovascular disease is well recognized in rheumatoid arthritis. Type 2 diabetes also attributes to this increase in risk. Rheumatoid arthritis is a chronic inflammatory condition, which aggravates insulin resistance, placing the patients at a higher risk of type 2 diabetes and subsequent cardiovascular outcomes. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0235637PLOS

A qualitative exploration of cardiovascular disease patients' views and experiences with an eHealth cardiac rehabilitation intervention: The PATHway Project.

PLoS One 2020 6;15(7):e0235274. Epub 2020 Jul 6.

Department of Health & Human Performance, Dublin City University, Dublin, Ireland.

The aim of this study is to explore participants' views and experiences of an eHealth phase 3 cardiac rehabilitation (CR) intervention: Physical Activity Towards Health (PATHway). Sixty participants took part in the PATHway intervention. Debriefs were conducted after the six-month intervention. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0235274PLOS

The association between walking speed and risk of cardiovascular disease in middle-aged and elderly people in Taiwan, a community-based, cross-sectional study.

PLoS One 2020 6;15(7):e0235277. Epub 2020 Jul 6.

Department of Family Medicine, Chang-Gung Memorial Hospital, Linkou Branch, Taoyuan City, Taiwan (R.O.C.).

Background And Aims: The aim of this study was to investigate the association between walking speed and cardiovascular disease (CVD) risk among community-dwelling middle-aged and elderly populations in Taiwan.

Methods: This was a cross-sectional and community-based study with 400 participants aged 50 years and over recruited from a community health promotion project in 2014 in Guishan district, Taoyuan city. We excluded 91 people, and a total of 309 participants were eligible for analysis. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0235277PLOS

Linking protein to phenotype with Mendelian Randomization detects 38 proteins with causal roles in human diseases and traits.

PLoS Genet 2020 Jul 6;16(7):e1008785. Epub 2020 Jul 6.

MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, Scotland, United Kingdom.

To efficiently transform genetic associations into drug targets requires evidence that a particular gene, and its encoded protein, contribute causally to a disease. To achieve this, we employ a three-step proteome-by-phenome Mendelian Randomization (MR) approach. In step one, 154 protein quantitative trait loci (pQTLs) were identified and independently replicated. Read More

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http://dx.doi.org/10.1371/journal.pgen.1008785DOI Listing

Comparison of the diagnostic performance with whole blood and plasma of four rapid antibody tests for SARS-CoV-2.

Clin Chem Lab Med 2020 Jul 6. Epub 2020 Jul 6.

Clinical Department of Laboratory Medicine and National Reference Center for Respiratory Pathogens, University Hospitals Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1515/cclm-2020-0817DOI Listing

Accurate Prediction of Coronary Heart Disease for Patients With Hypertension From Electronic Health Records With Big Data and Machine-Learning Methods: Model Development and Performance Evaluation.

JMIR Med Inform 2020 Jul 6;8(7):e17257. Epub 2020 Jul 6.

Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China.

Background: Predictions of cardiovascular disease risks based on health records have long attracted broad research interests. Despite extensive efforts, the prediction accuracy has remained unsatisfactory. This raises the question as to whether the data insufficiency, statistical and machine-learning methods, or intrinsic noise have hindered the performance of previous approaches, and how these issues can be alleviated. Read More

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http://dx.doi.org/10.2196/17257DOI Listing

Mobile Phone Technologies in the Management of Ischemic Heart Disease, Heart Failure, and Hypertension: Systematic Review and Meta-Analysis.

JMIR Mhealth Uhealth 2020 Jul 6;8(7):e16695. Epub 2020 Jul 6.

Department of Cardiology, Prince of Wales Hospital, Sydney, Australia.

Background: Cardiovascular disease (CVD) remains the leading cause of death worldwide. Mobile phones have become ubiquitous in most developed societies. Smartphone apps, telemonitoring, and clinician-driven SMS allow for novel opportunities and methods in managing chronic CVD, such as ischemic heart disease, heart failure, and hypertension, and in the conduct and support of cardiac rehabilitation. Read More

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http://dx.doi.org/10.2196/16695DOI Listing

Response by Jackson et al to Letter Regarding Article, "Effects of Sacubitril-Valsartan Versus Valsartan in Women Compared With Men With Heart Failure and Preserved Ejection Fraction: Insights From PARAGON-HF".

Circulation 2020 Jul 6;142(1):e5-e6. Epub 2020 Jul 6.

British Heart Foundation Cardiovascular Research Centre, University of Glasgow, United Kingdom (A.M.J., P.S.J., J.J.V.M.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.120.047275DOI Listing

Current Status of Cardiovascular Medicine in Israel.

Circulation 2020 Jul 6;142(1):17-19. Epub 2020 Jul 6.

Department of Cardiology, Rabin Medical Center, Petach Tikva; Faculty of Medicine, Tel Aviv University, Israel; and Israel Heart Society, Israel.

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http://dx.doi.org/10.1161/CIRCULATIONAHA.119.042516DOI Listing

Essential Amino Acids-Essential in Arterial Thrombosis.

Circulation 2020 Jul 6;142(1):65-67. Epub 2020 Jul 6.

Aab Cardiovascular Research Institute (Z.T.H., C.N.M.), University of Rochester School of Medicine, New York.

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http://dx.doi.org/10.1161/CIRCULATIONAHA.120.046817DOI Listing

Regulation Without Representation: Cardiac Device Patient Knowledge and Attitudes about the FDA Regulatory Process.

Circ Arrhythm Electrophysiol 2020 Jul 6. Epub 2020 Jul 6.

East Carolina University, Department of Psychology, Department of Cardiovascular Sciences, Greenville, NC.

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http://dx.doi.org/10.1161/CIRCEP.120.008561DOI Listing

Late I blocker GS967 Suppress Polymorphic VT in a Transgenic Rabbit Model of Long QT Type 2.

Circ Arrhythm Electrophysiol 2020 Jul 6. Epub 2020 Jul 6.

Cardiovascular Research Center, Division of Cardiology, Rhode Island Hospital, Alpert Medical School of Brown University, Providence, RI.

- Long QT syndrome (LQTS) has been associated with sudden cardiac death likely caused by early afterdepolarizations (EADs) and polymorphic ventricular tachycardias (PVTs). Suppressing the late sodium current (I) may counterbalance the reduced repolarization reserve in LQTS and prevent EADs and PVTs. - We tested the effects of the selective I blocker GS967 on PVT induction in a transgenic rabbit model of LQTS type 2 (LQT2) using intact heart optical mapping, cellular electrophysiology and confocal Ca imaging, and computer modeling. Read More

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http://dx.doi.org/10.1161/CIRCEP.118.006875DOI Listing

Efficacy and safety of clopidogrel and aspirin do not differ in patients with stable ischemic stroke.

J Chin Med Assoc 2020 Jul;83(7):651-656

aSchool of Health Care Administration, College of Management, Taipei Medical University, Taipei, Taiwan, ROC bHealth and Clinical Research Data Center, Office of Data, Taipei Medical University, Taipei, Taiwan, ROC cSchool of Public Health, College of Public Health, Taipei Medical University, Taipei, Taiwan, ROC dNeurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan, ROC eDepartment of Neurology, Faculty of Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan, ROC fDepartment of Neurology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan, ROC.

Background: The current study compared the efficacy and safety of clopidogrel vs aspirin in the secondary prevention of ischemic stroke (IS).

Methods: We included patients from the Taiwan National Health Insurance Research Database who were aged between 20 and 80 years, had their first ever IS, had no diagnosis of atrial fibrillation, and had not used an oral anticoagulant before the index IS between 2002 and 2010. We excluded patients who died or were admitted to a hospital due to acute myocardial infarction, recurrent IS, or major bleeding within 3 months of IS. Read More

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http://dx.doi.org/10.1097/JCMA.0000000000000361DOI Listing

2020 Consensus of Taiwan Society of Cardiology on the pharmacological management of patients with type 2 diabetes and cardiovascular diseases.

J Chin Med Assoc 2020 Jul;83(7):587-621

aGeneral Clinical Research Center, Taipei Veterans General Hospital, Taipei, Taiwan, ROC bDivision of Cardiology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, ROC cSchool of Medicine, National Yang-Ming University, Taipei, Taiwan, ROC dChung-Shan Medical University Hospital, Taichung, Taiwan, ROC eDepartment of Internal Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan, ROC fDepartment of Internal Medicine, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan, ROC gDepartment of Medicine, Mackay Medical College, New Taipei City, Taiwan, ROC hCardiovascular Center, Department of Internal Medicine, MacKay Memorial Hospital, Taipei, Taiwan, ROC iDepartment of Medicine, National Yang-Ming University, Taipei, Taiwan, ROC jDepartment of Internal Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, ROC kInstitute of Public Health and Community Medicine Research Center, National Yang-Ming University, Taipei, Taiwan, ROC lDivision of Cardiology, Department of Internal Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan, ROC mInstitute of Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan, ROC nDivision of Cardiovascular Medicine, China Medical University Hospital, Taichung, Taiwan, ROC oSchool of Medicine, China Medical University, Taichung, Taiwan, ROC pDivision of Cardiology, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan, ROC qCardiovascular center, Taichung Veterans General Hospital, Taichung, Taiwan, ROC rDepartment of Medicine, Changhua Christian Hospital, Changhua, Taiwan, ROC sDivision of Cardiology, Department of Internal Medicine, Hsinchu Mackay Memorial Hospital, Hsinchu, Taiwan, ROC tInstitute of Clinical Medicine, and Cardiovascular Research Center, National Yang-Ming University, Taipei, Taiwan, ROC uDivision of Cardiology, Department of Medicine, Tri-Service General Hospital, Taipei, Taiwan, ROC uCenter for Evidence-based Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, ROC vInstitute of Public Health, National Yang-Ming University, Taipei, Taiwan, ROC wInstitute of Health and Welfare Policy, National Yang-Ming University, Taipei, Taiwan, ROC xDepartment of Cardiology, Chang Gung Memorial Hospital, Taoyuan, Taiwan, ROC ySchool of Medicine, Chang Gung University, Taoyuan, Taiwan, ROC zHeart Center, Cheng Hsin General Hospital, Taipei, Taiwan, ROC aaDivision of Cardiology, Cardiovascular Medical Center, and Department of Nuclear, ROC Medicine, Far Eastern Memorial Hospital, New Taipei City, Taiwan, ROC abDepartment of Internal Medicine and Nuclear Medicine, National Taiwan University Hospital, Taipei, Taiwan, ROC acDivision of Cardiology, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan, ROC adTaipei Heart Institute, Taipei Medical University, Taipei, Taiwan, ROC aeDepartment of Medical Research, Taipei Veterans General Hospital, Taipei, Taiwan, ROC afInstitute of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan, ROC agCardiovascular Division, Department of Internal Medicine, National Taiwan, ROC, University College of Medicine and Hospital, Taipei, Taiwan, ROC ahCardiovascular Center, National Taiwan University Hospital Yunlin Branch, Yunlin, Taiwan, ROC.

The global incidence and prevalence of type 2 diabetes have been escalating in recent decades. The total diabetic population is expected to increase from 415 million in 2015 to 642 million by 2040. Patients with type 2 diabetes have an increased risk of atherosclerotic cardiovascular disease (ASCVD). Read More

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http://dx.doi.org/10.1097/JCMA.0000000000000359DOI Listing
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