1,843,463 results match your criteria Cardiovascular engineering Dordrecht Netherlands[Journal]


Quantification of citrullinated histones: development of an improved assay to reliably quantify nucleosomal H3Cit in human plasma.

J Thromb Haemost 2020 Jul 12. Epub 2020 Jul 12.

EpiCypher Inc, Durham, North Carolina, USA.

Background: Recent data propose a diagnostic and prognostic capacity for citrullinated histone H3 (H3Cit), a marker of neutrophil extracellular traps (NETs), in pathologic conditions such as cancer and thrombosis. However, current research is hampered by lack of standardized assays.

Objectives: We aimed to develop an assay to reliably quantify nucleosomal H3Cit in human plasma. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/jth.15003DOI Listing

Targeting hepatocyte carbohydrate transport to mimic fasting and calorie restriction.

FEBS J 2020 Jul 12. Epub 2020 Jul 12.

Department of Pediatrics, Washington University School of Medicine, St. Louis, MO, USA.

The pervasion of three daily meals and snacks is a relatively new introduction to our shared experience, and is coincident with an epidemic rise in obesity and cardiometabolic disorders of overnutrition. The past two decades have yielded convincing evidence regarding the adaptive, protective effects of calorie restriction (CR) and intermittent fasting (IF) against cardiometabolic, neurodegenerative, proteostatic and inflammatory diseases. Yet, durable adherence to intensive lifestyle changes is rarely attainable. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/febs.15482DOI Listing

The Association of Non-Alcoholic Fatty Liver Disease and Cardiac Structure and Function - Framingham Heart Study.

Liver Int 2020 Jul 11. Epub 2020 Jul 11.

Section of Gastroenterology, Boston Medical Center, Boston University School of Medicine, Boston, MA, United States.

Background & Aims: Non-alcoholic fatty liver disease confers increased risk for cardiovascular disease, including heart failure, for reasons that remain unclear. Possible pathways could involve an association of liver fat with cardiac structural or functional abnormalities even after accounting for body size.

Methods: We analyzed N=2,356 Framingham Heart Study participants (age 52±12 years, 52% women) who underwent echocardiography and standardized computed tomography (CT) measures of liver fat. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/liv.14600DOI Listing

Liver histopathology in severe COVID 19 respiratory failure is suggestive of vascular alterations.

Liver Int 2020 Jul 12. Epub 2020 Jul 12.

Dept. Biomedical and Clinical Sciences, University of Milan, Italy.

SARS2-CoV-2 breakout in Italy caused a huge number of severely ill patients with a serious increase in mortality. Although lungs seem to be the main target of the infection, very few information are available about liver involvement, possibly evocating a systemic disease. Post-mortem wedge liver biopsies from 48 patients died for severe pulmonary COVID-19 disease with respiratory failure were collected from two main hospitals in northern Italy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/liv.14601DOI Listing

Cardiovascular magnetic resonance in heart failure with preserved ejection fraction: myocyte, interstitium, microvascular, and metabolic abnormalities.

Eur J Heart Fail 2020 Jul 12. Epub 2020 Jul 12.

Cardiovascular Department, ASST Papa Giovanni XXIII, Bergamo, IT.

Heart failure (HF) with preserved ejection fraction (HFpEF) is a chronic cardiac condition whose prevalence continues to rise, with high social and economic burden, but with no specific approved treatment. Patients diagnosed with HFpEF have a high prevalence of comorbidities and there is a likely high misdiagnosis rate. True HFpEF is likely to have multiple pathophysiological causes - with these causes themselves clinically ill-defined through limitations of current measurement techniques. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/ejhf.1961DOI Listing

Risk scores for occult cancer in patients with unprovoked venous thromboembolism: results from an individual patient data meta-analysis.

J Thromb Haemost 2020 Jul 12. Epub 2020 Jul 12.

Department of Vascular Medicine, Amsterdam University Medical Centers, Amsterdam Cardiovascular Sciences, Amsterdam, The Netherlands.

Background: The RIETE and SOME risk scores aim to identify patients with acute unprovoked venous thromboembolism (VTE) at high risk of occult cancer, but their predictive performance is unclear.

Methods: The scores were evaluated in an individual-patient data meta-analysis. Studies were eligible if enrolling consecutive adults with unprovoked VTE who underwent protocol-mandated screening for cancer. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/jth.15001DOI Listing

Did the 2017 ACC/AHA blood pressure guideline get it wrong in reducing the diastolic threshold to define hypertension from 90 to 80 mmHg?

J Clin Hypertens (Greenwich) 2020 Jul 11. Epub 2020 Jul 11.

School of Medicine, National University of Ireland Galway, National Institute for Prevention and Cardiovascular Health, Galway, Ireland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/jch.13899DOI Listing

Usefulness of echocardiography to detect cardiac involvement in COVID-19 patients.

Echocardiography 2020 Jul 12. Epub 2020 Jul 12.

Department of Medical Biotechnologies, Division of Cardiology, University of Siena, Siena, Italy.

Coronavirus disease 2019 (COVID-19) outbreak is a current global healthcare burden, leading to the life-threatening severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, evidence showed that, even if the prevalence of COVID-19 damage consists in pulmonary lesions and symptoms, it could also affect other organs, such as heart, liver, and spleen. Particularly, some infected patients refer to the emergency department for cardiovascular symptoms, and around 10% of COVID-19 victims had finally developed heart injury. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/echo.14779DOI Listing

Trajectory of extracellular fluid volume over time and subsequent risks of end-stage kidney disease and mortality in chronic kidney disease: a prospective cohort study.

J Intern Med 2020 Jul 12. Epub 2020 Jul 12.

Medical Intensive Care Unit, AP-HP, Hôpital Ambroise Paré, Boulogne-Billancourt, France.

Background: Extracellular fluid volume (ECF) is independently associated with chronic kidney disease (CKD) progression and mortality in patients with CKD, but the prognostic value of the trajectory of ECF over time beyond that of baseline value is unknown.

Objectives: To characterize ECF trajectory and evaluate its association with the risks of end-stage kidney disease (ESKD) and mortality.

Methods: From the prospective tricentric NephroTest cohort, we included 1588 patients with baseline measured glomerular filtration rate (mGFR) ≥15mL/min/1. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/joim.13151DOI Listing

Targeting the NLRP3-inflammasome to reduce warm ischemic injury in donation after circulatory death heart.

Clin Transplant 2020 Jul 12:e14044. Epub 2020 Jul 12.

Pauley Heart Center, Division of Cardiology, Virginia Commonwealth University, Richmond, VA, 23298, United States.

While the donation after circulatory death (DCD) heart transplantation is an emerging clinical practice, the primary source of donor hearts for transplantation remains donation after brain death (DBD) donors. DCD process induces formation of NOD-Like Receptor Family Pyrin Domain Containing-3 (NLRP3)-inflammasome, a key mediator of inflammation-driven damage to heart. Inhibition of NLRP3-inflammasome formation could be protective to DCD hearts. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/ctr.14044DOI Listing

Determinants of clinical outcomes in patients with mixed mitral valve disease.

Echocardiography 2020 Jul 12. Epub 2020 Jul 12.

Division of Cardiology, Severance Cardiovascular Hospital, Yonsei University College of Medicine, Seoul, Korea.

Background: Although significant stenosis and regurgitation can be observed on a single heart valve, studies on the outcome predictors for mixed valve disease are limited. The purpose of the current study was to investigate the fate and determinants of clinical outcomes in patients with mixed single mitral valve disease who have concomitant mitral stenosis (MS) and mitral regurgitation (MR).

Methods: We retrospectively reviewed 82 consecutive patients with rheumatic heart disease who had both significant MS (MVA ≤ 1. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/echo.14673DOI Listing

FoxO1a mediated cadmium-induced annulus fibrosus cells apoptosis contributes to intervertebral disc degeneration in smoking.

J Cell Physiol 2020 Jul 11. Epub 2020 Jul 11.

Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Cadmium (Cd), a type of heavy metal that accumulates in the body because of smoking, mediates the toxic effect of smoking in many diseases, such as cardiovascular disease, osteoarthritis, and osteoporosis. However, the toxic effect of Cd on intervertebral disc tissues have not been reported. In the current study, we demonstrated that Cd induced the apoptosis of annulus fibrosus (AF) cells, which contributed to intervertebral disc degeneration (IVDD). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jcp.29895DOI Listing

Diabetes and subclinical hypothyroidism on heart rate variability.

Eur J Clin Invest 2020 Jul 12:e13349. Epub 2020 Jul 12.

Center for Clinical and Epidemiological Research of University Hospital, University of Sao Paulo, Sao Paulo - SP, Brazil.

Background: To analyze the interaction effects between diabetes and subclinical hypothyroidism with respect to heart rate variability parameters, using baseline data from the Brazilian Longitudinal Study of Adult Health.

Materials And Methods: The subsample was categorized into four groups: subjects without diabetes and normal thyroid function (controls); subjects without diabetes and subclinical hypothyroidism; patients with diabetes and normal thyroid function; and patients with diabetes and subclinical hypothyroidism. Heart rate variability analyses were performed by linear time and frequency domain analyses in 5-minute time series collected in the supine position. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/eci.13349DOI Listing

Cardiovascular risk estimation with 5 different algorithms before and after 5 years of bDMARD treatment in Rheumatoid Arthritis.

Eur J Clin Invest 2020 Jul 12:e13343. Epub 2020 Jul 12.

Rheumatology Unit - Department of Emergence Medicine and Transplantation (DETO), University of Bari.

Background: Assessing cardiovascular (CV) risk represents a challenge for clinicians because more variables can impact CV risk. The aim of this study was to evaluate the change of CV risk after 5 years of biologic treatment in Rheumatoid Arthritis (RA) patients and impact of prolonged low disease activity on 5 different CV risk algorithms.

Materials And Methods: We estimated the CV risk, at baseline and at 5-years follow-up (FU), with the Systematic COronary Risk Evaluation(SCORE) charts, the algorithm "Progetto Cuore", the QRISK2-2017 score, the Reynolds Risk Score(RRS) and the Expanded Risk Score in RA(ERS-RA). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/eci.13343DOI Listing

Peritoneal dialysis: the ideal bridge from conservative therapy to kidney transplant.

J Nephrol 2020 Jul 11. Epub 2020 Jul 11.

Division of Nephrology, Department of Medicine, The University of Hong Kong, Queen Mary Hospital, 102 Pokfulam Road, Hong Kong, China.

Background: Kidney transplantation offers the best potential for full rehabilitation in patients with end-stage kidney disease who are treated with dialysis. However, due to organ shortage which is a universal phenomenon, most patients need to be maintained on a period of dialysis therapy before the prospect of transplantation. Peritoneal dialysis (PD) could be an ideal form of renal replacement therapy due to its favorable profile toward preservation of residual renal function, patient survival, lower overall burden on cardiovascular morbidity and infection risks. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s40620-020-00787-0DOI Listing

Long-term results of the edge-to-edge repair for failed mitral valve repair as a bailout option.

Gen Thorac Cardiovasc Surg 2020 Jul 11. Epub 2020 Jul 11.

Department of Cardiovascular Surgery, Fuwai Hospital, Chinese Academy of Medical Science, No. 167, North Lishi Road, Xicheng District, Beijing, 100037, China.

Objective: We evaluate the long-term clinical and echocardiographic outcomes of edge-to-edge (E2E) repair combined with mitral annuloplasty in our institute with degenerative mitral regurgitation (MR) up to 10 years.

Methods: Twenty-six consecutive patients undergoing E2E mitral repair after failure of other conventional mitral repair technique. There were 16 (61. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11748-020-01433-zDOI Listing

Thoracoscopic repair of diaphragmatic hernia following ventricular assist device implantation.

Surg Case Rep 2020 Jul 11;6(1):170. Epub 2020 Jul 11.

Department of Pediatric Surgery, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan.

Background: Diaphragmatic hernia is a rare complication of ventricular assist device (VAD), mainly developing after explantation of the device. We herein report a case of diaphragmatic hernia that developed following the implantation of VAD.

Case Presentation: A 4-month-old girl with a diagnosis of dilated cardiomyopathy underwent VAD implantation for a bridge to heart transplantation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s40792-020-00933-7DOI Listing

Thrombotic circuit complications during venovenous extracorporeal membrane oxygenation in COVID-19.

J Thromb Thrombolysis 2020 Jul 11. Epub 2020 Jul 11.

Department of Medicine III (Interdisciplinary Medical Intensive Care), Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Hugstetter Straße 55, 79106, Freiburg, Germany.

The novel coronavirus SARS-CoV-2 and the resulting disease COVID-19 causes pulmonary failure including severe courses requiring venovenous extracorporeal membrane oxygenation (V-V ECMO). Coagulopathy is a known complication of COVID-19 leading to thrombotic events including pulmonary embolism. It is unclear if the coagulopathy also increases thrombotic circuit complications of the ECMO. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11239-020-02217-1DOI Listing

Mechanistic implications of altered protein expression in rheumatic heart disease.

Heart Fail Rev 2020 Jul 11. Epub 2020 Jul 11.

Division of Cardiology, Department of Medicine, Faculty of Health Sciences and Groote Schuur Hospital, University of Cape Town, Cape Town, South Africa.

Rheumatic heart disease (RHD) is a major cause of cardiovascular morbidity and mortality in low- and middle-income countries, where living conditions promote spread of group A β-haemolytic streptococcus. Autoimmune reactions due to molecular mimicry of bacterial epitopes by host proteins cause acute rheumatic fever (ARF) and subsequent disease progression to RHD. Despite knowledge of the factors that predispose to ARF and RHD, determinants of the progression to valvular damage and the molecular events involved remain incompletely characterised. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10741-020-09993-1DOI Listing

Purine Metabolism in Platelets and Heart Cells of Hyperlipidemic Rats.

Cardiovasc Drugs Ther 2020 Jul 11. Epub 2020 Jul 11.

Laboratório de Imunobiologia Experimental e Aplicada (LABIBIO), Departamento de Microbiologia e Parasitologia, Centro de Ciências da Saúde, Universidade Federal de Santa Maria, Santa Maria, RS, Brazil.

Purpose: Hyperlipidemia, characterized by an increase in circulating lipid levels, doubles the chance of developing cardiovascular diseases. It prompts inflammation, immune activation, and oxidative stress in the bloodstream and organs of rats. Thus, we theorized that the metabolism of purines, an immunomodulatory mechanism, is altered in cells involved in the development of cardiovascular diseases. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10557-020-07034-5DOI Listing

The Ability of the Nottingham Hip Fracture Score to Predict Mobility, Length of Stay and Mortality in Hospital, and Discharge Destination in Patients Admitted with a Hip Fracture.

Calcif Tissue Int 2020 Jul 11. Epub 2020 Jul 11.

Institute of Cardiovascular Research, Royal Holloway, University of London, Egham, Surrey, TW20 0EX, UK.

The Nottingham Hip Fracture Score (NHFS) has been developed for predicting 30-day and 1-year mortality after hip fracture. We hypothesise that NHFS may also predict other adverse events. Data from 666 patients (190 men, 476 women), aged 60. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00223-020-00722-2DOI Listing

Additive Protective Effects of Sacubitril/Valsartan and Bosentan on Vascular Remodeling in Experimental Pulmonary Hypertension.

Cardiovasc Res 2020 Jul 11. Epub 2020 Jul 11.

INSERM UMR_S 999 «Pulmonary Hypertension: Pathophysiology and Novel Therapies», Hôpital Marie Lannelongue, 92350 Le Plessis-Robinson, France.

Aims: Although right ventricular (RV) function is an important determinant of morbidity and mortality in patients with pulmonary arterial hypertension (PAH), there is no treatment targeting directly the RV. We therefore evaluate the efficacy of sacubitril/valsartan (LCZ 696) as add-on therapy to bosentan in rats with severe pulmonary hypertension (PH).

Methods And Results: Combination therapy of LCZ 696 and bosentan has additive vascular protective effects against the pulmonary vascular remodeling and PH in two preclinical models of severe PH. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/cvr/cvaa200DOI Listing

Diet-induced dyslipidemia induces metabolic and migratory adaptations in regulatory T cells.

Cardiovasc Res 2020 Jul 11. Epub 2020 Jul 11.

Division of BioTherapeutics, LACDR, Leiden University, Leiden, The Netherlands.

Aims: A hallmark of advanced atherosclerosis is inadequate immunosuppression by regulatory T (Treg) cells inside atherosclerotic lesions. Dyslipidemia has been suggested to alter Treg cell migration by affecting the expression of specific membrane proteins, thereby decreasing Treg cell migration towards atherosclerotic lesions. Besides membrane proteins, cellular metabolism has been shown to be a crucial factor in Treg cell migration. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/cvr/cvaa208DOI Listing

VE-PTP inhibition elicits eNOS phosphorylation to blunt endothelial dysfunction and hypertension in diabetes.

Cardiovasc Res 2020 Jul 11. Epub 2020 Jul 11.

Institute for Vascular Signalling, Centre for Molecular Medicine, Goethe University, Frankfurt am Main, Germany.

Aims: Receptor-type vascular endothelial protein tyrosine phosphatase (VE-PTP) dephosphorylates Tie-2 as well as CD31, VE-cadherin and VEGFR2. The latter form a signal transduction complex that mediates the endothelial cell response to shear stress, including the activation of the endothelial nitric oxide (NO) synthase (eNOS). As VE-PTP expression is increased in diabetes, we investigated the consequences of VE-PTP inhibition (using AKB-9778) on blood pressure in diabetic patients and the role of VE-PTP in the regulation of eNOS activity and vascular reactivity. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/cvr/cvaa213DOI Listing

Mortality, causes of death and influence of medication use in patients with systemic lupus erythematosus vs matched controls.

Rheumatology (Oxford) 2020 Jul 12. Epub 2020 Jul 12.

Division of Pharmacoepidemiology & Clinical Pharmacology, Utrecht University, Utrecht.

Objectives: We wanted to estimate the magnitude of the risk from all-cause, cause-specific and sex-specific mortality in patients with SLE and relative risks compared with matched controls and to evaluate the influence of exposure to medication on risk of mortality in SLE.

Methods: We conducted a population-based cohort study using the Clinical Practice Research Datalink, Hospital Episode Statistics and national death certificates (from 1987 to 2012). Each SLE patient (n = 4343) was matched with up to six controls (n = 21 780) by age and sex. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/rheumatology/keaa267DOI Listing

Coronary Subclavian Steal Syndrome: A Contemporary Review.

Cardiology 2020 Jul 10:1-7. Epub 2020 Jul 10.

Department of Cardiovascular Medicine, Heart, Vascular and Thoracic Institute, Cleveland Clinic, Cleveland, Ohio, USA,

Coronary subclavian steal syndrome (CSSS) is a rare cause of angina. It occurs in patients with prior coronary artery bypass grafting and, specifically, a left internal mammary artery (LIMA) to left anterior descending artery (LAD) graft and co-existent significant subclavian artery stenosis. In this context, there is retrograde blood flow through the LIMA to LAD graft to supply the subclavian artery beyond the significant stenosis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000508652DOI Listing

The combined effect of regular alcohol consumption and smoking on blood pressure and on the achievement of blood pressure target values in treated hypertensive patients

Orv Hetil 2020 07;161(30):1252-1259

Általános Kardiológiai Profil,Szent Imre Egyetemi Oktatókórház, Budapest, Tétényi út 12-16., 1115.

Introduction: The combined effect of alcohol consumption and smoking on hypertension in hypertensive patients is still not completely clear, although both are known to be cardiovascular risk factors.

Aim: The aim of our study was to compare the blood pressure, the achievement of target blood pressure and heart rate of non-smokers and non-drinkers in the middle-aged hypertensive patients with those who smoke and drink regularly.

Method: From the database of the Hungarian Hypertension Registry, 12 615 patients (6341 men and 6274 women) aged 45-64 years were included in the current analysis, who self-reported smoking habit and alcohol consumption. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1556/650.2020.31766DOI Listing

Diabetic neuropathy and other diabetic complications at the Diabetic Neuropathy Center of the University of Debrecen

Orv Hetil 2020 07;161(30):1243-1251

Általános Orvostudományi Kar, Anyagcsere Betegségek Nem Önálló Tanszék, Belgyógyászati Intézet,D Debreceni Egyetem, Debrecen, Nagyerdei krt. 98., 4032.

Introduction: The prevalence of diabetes mellitus is significantly increasing worldwide. Distal sensorimotor neuropathy (DSPN) is the most common and the earliest detectable microvascular complication. Due to its diverse clinical appearance and atypical symptoms, DSPN is often recognized in an advanced stage. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1556/650.2020.31799DOI Listing

Mitochondria in acute myocardial infarction and cardioprotection.

EBioMedicine 2020 Jul 9;57:102884. Epub 2020 Jul 9.

National Heart Research Institute Singapore, National Heart Centre, Singapore; Cardiovascular & Metabolic Disorders Program, Duke-National University of Singapore Medical School, Singapore; Department of Biochemistry, Medical Faculty, Justus Liebig-University, Giessen, Germany; Yong Loo Lin School of Medicine, National University Singapore, Singapore; The Hatter Cardiovascular Institute, University College London, London, UK; Cardiovascular Research Center, College of Medical and Health Sciences, Asia University, Taiwan. Electronic address:

Acute myocardial infarction (AMI) and the heart failure (HF) that often follows are among the leading causes of death and disability worldwide. As such, new treatments are needed to protect the myocardium against the damaging effects of the acute ischaemia and reperfusion injury (IRI) that occurs in AMI, in order to reduce myocardial infarct (MI) size, preserve cardiac function, and improve patient outcomes. In this regard, cardiac mitochondria play a dual role as arbiters of cell survival and death following AMI. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ebiom.2020.102884DOI Listing

Scrutinizing the molecular, biochemical, and cytogenetic attributes in subjects with Rett syndrome (RTT) and their mothers.

Epilepsy Behav 2020 Jul 9;111:107277. Epub 2020 Jul 9.

Human Genetics Laboratory, Department of Zoology, School of Life Sciences, Bharathiar University, 641046, Tamil Nadu, India. Electronic address:

Rett syndrome (RTT) is a stern dominant progressive neurological development disorder linked with X chromosome ranking second for mental slowdown, exclusively in females after few months of birth with normal development and growth period. Genetically any defects in universally expressed methyl-CpG binding protein 2 (MeCP2) transcription regulator gene are considered as radix for RTT in almost all the previous studies. Our study mainly focuses in unraveling the genetic alterations like identifying MeCP2 gene polymorphisms, chromosomal abnormalities, or X-chromosome inactivation (XCI) as underlying cause of RTT in prototypes sorted through Diagnostic and Statistical Manual of Mental Disorders-Text Revised (DSM IV). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.yebeh.2020.107277DOI Listing

'Big boys don't cry': Examining the indirect pathway of masculinity discrepancy stress and muscle dysmorphia symptomatology through dimensions of emotion dysregulation.

Body Image 2020 Jul 9;34:209-214. Epub 2020 Jul 9.

Department of Psychiatry and Behavioral Sciences, University of Southern California, Los Angeles, CA, USA.

Prevailing conceptualizations of muscle dysmorphia (MD) have highlighted the role of adherence to stereotypical ideals of masculinity. In addition, the endorsement of masculine norms has been associated with dysfunctional emotional regulation, itself a correlate of body image psychopathology. Building on this, the present study sought to investigate the indirect relationship between masculinity discrepancy stress (i. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bodyim.2020.05.014DOI Listing

Immunosenescence exacerbates the COVID-19.

Arch Gerontol Geriatr 2020 Jul 3;90:104174. Epub 2020 Jul 3.

Cardiology and Cardiovascular Pathophysiology, Azienda Ospedaliero-Universitaria "S. Maria della Misericordia", University of Perugia, Perugia, Italy; Cardiovascular Department, MultiMedica IRCCS, Sesto San Giovanni, Milan, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.archger.2020.104174DOI Listing

Long non-coding RNA Linc00092 inhibits cardiac fibroblast activation by altering glycolysis in an ERK-dependent manner.

Cell Signal 2020 Jul 9:109708. Epub 2020 Jul 9.

Department of Cardiology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510120, PR China; Laboratory of Cardiac Electrophysiology and Arrhythmia in Guangdong Province, Guangzhou, Guangdong 510120, PR China. Electronic address:

Aims: Cardiac fibroblast (CF) activation is the key event for cardiac fibrosis. The role of glycolysis and the glycolysis-related lncRNAs in CF activation are unknown. Thus, we aimed to investigate the role of glycolysis in CF activation and to identify the glycolysis-related lncRNAs involved. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cellsig.2020.109708DOI Listing

Atypical skin manifestations during immune checkpoint blockage in COVID19-infected lung cancer patients.

J Thorac Oncol 2020 Jul 9. Epub 2020 Jul 9.

Thoracic Oncology Unit, Instituto Nacional de Cancerología (INCan), México City, México.

A new coronavirus, named SARS-CoV-2 by the World Health Organization (WHO), has rapidly spread around the world since its first reported case in late December of 2019 from Wuhan, China. As of mid-April 2020, this virus has affected more than 180 countries and territories, infecting more than 1,650,000 individuals and causing over 100.000 deaths. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jtho.2020.06.019DOI Listing

Swollen Painful Neck: A Case of a Ruptured Venous Malformation.

Ann Vasc Surg 2020 Jul 9. Epub 2020 Jul 9.

Department of Cardiovascular Surgery, Kaohsiung Medical University Hospital. Electronic address:

A 16-year-old male was brought to our hospital presenting with acute onset of a painful protruding left neck mass within a day, associated with left upper-arm tenderness. Chest-computed tomography revealed high attenuation masses at the left supraclavicular and mediastinal regions, suspected of being venous vascular tumors. Surgery was arranged and then ruptured venous tumor was noted, with pathology results determining a venous malformation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.avsg.2020.07.003DOI Listing

Non-steroidal anti-inflammatory drugs (NSAIDs) and organ damage: a current perspective.

Biochem Pharmacol 2020 Jul 9:114147. Epub 2020 Jul 9.

Division of Infectious Diseases and Immunology, CSIR-Indian Institute of Chemical Biology, 4 Raja S.C. Mullick Road, Kolkata 700032, West Bengal, India; Division of Molecular Medicine, Bose Institute, P-1/12, CIT Rd, Scheme VIIM, Kankurgachi, Kolkata, West Bengal 700054 India. Electronic address:

Owing to the efficacy in reducing pain and inflammation non-steroidal anti-inflammatory drugs (NSAIDs) are amongst the most popularly used medicines, confirming their position in the WHO's Model List of Essential Medicines. With escalating musculoskeletal complications, as evident from 2016 Global Burden of Disease data, NSAID usage is evidently unavoidable. Apart from analgesic, anti-inflammatory and antipyretic efficacies, NSAIDs are further documented to offer protection against diverse critical disorders including cancer and heart attacks. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bcp.2020.114147DOI Listing

Beginning with the End in Mind - The Case for Primordial and Primary Cardiovascular Prevention in Youth.

Can J Cardiol 2020 Jul 9. Epub 2020 Jul 9.

Department of Pediatrics, Section of Cardiology, University of Colorado School of Medicine, Aurora, Colorado.

Cardiovascular disease (CVD) remains the leading cause of death worldwide. While there is little direct evidence that ties the presence of risk factors in childhood with adult cardiovascular disease, there are multiple indirect lines of evidence that, when synthesized, make a strong case for maintaining cardiovascular health through childhood and adolescence, as well as screening for and treating risk factors when they develop to diminish lifetime risk. This review summarizes these lines of evidence and asserts that it is imperative that primordial and primary cardiovascular risk reduction begin early. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cjca.2020.07.002DOI Listing

The effect of retirement on biomedical and behavioral risk factors for cardiovascular and metabolic disease.

Econ Hum Biol 2020 May 29;38:100893. Epub 2020 May 29.

Institute of Health Economics and Health Care Management, Helmholtz Zentrum München, German Research Center for Environmental Health, Ingolstädter Landstr. 1, 85764 Neuherberg, Germany; Department of Economics, Martin Luther University Halle-Wittenberg, 06099 Halle (Saale), Germany.

Retirement is a major life event potentially associated with changes in relevant risk factors for cardiovascular and metabolic conditions. This study analyzes the effect of retirement on behavioral and biomedical risk factors for chronic disease, together with subjective health parameters using Southern German epidemiological data. We used panel data from the KORA cohort study, consisting of 11,168 observations for individuals 45-80 years old. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ehb.2020.100893DOI Listing

Myocarditis in Relation to Angiographic Findings in Patients With Provisional Diagnoses of MINOCA.

JACC Cardiovasc Imaging 2020 Jun 17. Epub 2020 Jun 17.

Soter Center for Women's Cardiovascular Research, Leon H. Charney Division of Cardiology, Department of Medicine, New York University School of Medicine, New York, New York. Electronic address:

Objectives: The aim of this study was to determine the prevalence of myocarditis among patients presenting with myocardial infarction with nonobstructive coronary arteries (MINOCA) in relation to the angiographic severity of nonobstructive coronary artery disease (CAD).

Background: MINOCA represents about 6% of all cases of acute myocardial infarction. Myocarditis is a diagnosis that may be identified by cardiac magnetic resonance (CMR) imaging in patients with a provisional diagnosis of MINOCA. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jcmg.2020.02.037DOI Listing

T Mapping Tissue Heterogeneity Provides Improved Risk Stratification for ICDs without needing Gadolinium in Patients with Dilated Cardiomyopathy.

JACC Cardiovasc Imaging 2020 Jun 18. Epub 2020 Jun 18.

Department of Medicine, Cardiovascular Division, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts. Electronic address:

Objectives: This study sought to determine whether myocardial tissue heterogeneity scanned by native T mapping could improve risk stratification in patients with nonischemic dilated cardiomyopathy (NICM) evaluated for primary prevention by ICD.

Background: The benefit of insertable cardiac-defibrillator (ICD) as primary prevention ICD in patients with NICM remains to be fully clarified.

Methods: A total of 115 NICM candidates for primary prevention and 55 healthy controls with similar distributions of age and sex were prospectively enrolled. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jcmg.2020.03.014DOI Listing

Estrogen-dependent microRNA-504 expression and related baroreflex afferent neuroexcitation via negative regulation on KCNMB4 and KCa1.1 β4-subunit expression.

Neuroscience 2020 Jul 9. Epub 2020 Jul 9.

Department of Pharmacology (State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Medicine Research, Ministry of Education), Harbin Medical University School of Pharmacy, Harbin, China. Electronic address:

Large conductance of Ca-activated K channel (KCa1.1) plays an inhibitory role in neuroexcitation. However, the expression of KCNMB4/β4-subunit in the nodose ganglia (NG) and nucleus tractus solitarius, and its effect and regulation on baroreflex afferent function at post-transcriptional level of female rats remains unknown. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neuroscience.2020.07.003DOI Listing

Good or bad: Application of RAAS inhibitors in COVID-19 patients with cardiovascular comorbidities.

Pharmacol Ther 2020 Jul 9:107628. Epub 2020 Jul 9.

Division of Cardiology, Department of Internal Medicine and Hubei Key Laboratory of Genetics and Molecular Mechanisms of Cardiological Disorders, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. Electronic address:

The coronavirus disease 2019 (COVID-19) pandemic is caused by a newly emerged coronavirus (CoV) called Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2). COVID-19 patients with cardiovascular disease (CVD) comorbidities have significantly increased morbidity and mortality. The use of angiotensin-converting enzyme (ACE) inhibitors and angiotensin II receptor type 1 blockers (ARBs) improve CVD outcomes; however, there is concern that they may worsen the prognosis of CVD patients that become infected with SARS-CoV-2 because the virus uses the ACE2 receptor to bind to and subsequently infect host cells. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.pharmthera.2020.107628DOI Listing

Premature Peripheral Arterial Disease: A Consequence of Accelerated Vascular Aging Due to Less than Ideal Cardiovascular Health?

Authors:
Jane A Leopold

Trends Cardiovasc Med 2020 Jul 9. Epub 2020 Jul 9.

Brigham and Women's Hospital, Harvard Medical School, Division of Cardiovascular Medicine. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.tcm.2020.06.011DOI Listing

Genomic insights into evolution of extensive drug resistance in Stenotrophomonas maltophilia complex.

Genomics 2020 Jul 9. Epub 2020 Jul 9.

Bacterial Genomics and Evolution Laboratory, CSIR-Institute of Microbial Technology, Chandigarh, India. Electronic address:

We report first complete genomic investigation of extensive drug resistance (XDR) in a nosocomial Stenotrophomonas maltophilia complex strain that is resistant to mainstream drugs (trimethoprim/sulfamethoxazole and levofloxacin). Comprehensive genomic investigation revealed its exclusive fourteen dynamic regions and highly enriched resistome comprising of two sulfonamide resistance genes on two diverse super-integrons of chromosomal origin. In addition, both these integrons harbors array of antibiotic resistance and commonly used disinfectants resistace genes linked to ISCR elements. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ygeno.2020.06.049DOI Listing

The French Paradox three decades later: Role of inflammation and thrombosis.

Clin Chim Acta 2020 Jul 9. Epub 2020 Jul 9.

School of Health Science and Education, Department of Nutrition and Dietetics, Harokopio University.

Although, three decades have pasted from the introduction of "French Paradox", is still an issue for debate. Epidemiology supports the J-shaped relationship between wine consumption and vascular events as well as cardiovascular mortality with a maximum protection at 21g of alcohol consumption in the form of wine per day. Nevertheless, the aforementioned studies have used an observational design that raises concerns about potential confounding. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cca.2020.07.013DOI Listing

Hemodynamic and Functional Impact of Epicardial Adipose Tissue in Heart Failure With Preserved Ejection Fraction.

JACC Heart Fail 2020 Jul 3. Epub 2020 Jul 3.

Department of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota. Electronic address:

Objectives: This study determined the impact of excess epicardial adipose tissue (EAT) in patients with the obese phenotype of heart failure with preserved ejection fraction (HFpEF).

Background: Patients with HFpEF and an elevated body mass index differ from nonobese patients, but beyond generalized obesity, fat distribution may be more important. Increases in EAT are associated with excess visceral adiposity, inflammation, and cardiac fibrosis, and EAT has been speculated to play an important role in the pathophysiology of HFpEF, but no study has directly evaluated this question. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jchf.2020.04.016DOI Listing

Effect of Dapagliflozin in Patients With HFrEF Treated With Sacubitril/Valsartan: The DAPA-HF Trial.

JACC Heart Fail 2020 Jul 5. Epub 2020 Jul 5.

BHF Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, Scotland.

Objectives: This study assessed the efficacy and safety of dapagliflozin in patients who were or were not taking sacubitril/valsartan at baseline in the DAPA-HF (Study to Evaluate the Effect of Dapagliflozin on the Incidence of Worsening Heart Failure or Cardiovascular Death in Patients With Chronic Heart Failure) trial.

Background: Both the angiotensin receptor neprilysin-inhibitor sacubitril/valsartan and the sodium glucose co-transporter 2 inhibitor dapagliflozin reduced cardiovascular death and heart failure (HF) hospitalization in patients with HF with reduced ejection fraction (HFrEF). Whether either of these classes of drugs influences the effectiveness or safety of the other remains unknown. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jchf.2020.04.008DOI Listing

Sex Differences in Patients Receiving Left Ventricular Assist Devices for End-Stage Heart Failure.

JACC Heart Fail 2020 Jul 5. Epub 2020 Jul 5.

Center for Outcomes Research and Evaluation, Yale University School of Medicine, New Haven, Connecticut; Section of Cardiovascular Medicine, Yale University School of Medicine, New Haven, Connecticut. Electronic address:

Objectives: This study sought to use INTERMACS (Interagency Registry for Mechanically Assisted Circulatory Support) results to evaluate sex differences in the use and clinical outcomes of left ventricular assist devices (LVAD).

Background: Despite a similar incidence of heart failure in men and women, prior studies have highlighted potential underuse of LVADs in women, and studies of clinical outcomes have yielded conflicting results.

Methods: Patients were enrolled from the INTERMACS study who underwent implantation of their first continuous-flow LVAD between 2008 and 2017, and survival analyses stratified by sex were conducted. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jchf.2020.04.015DOI Listing

Amplitude of QRS complex within initial 40 ms in V (VQRS): Novel electrocardiographic criterion for predicting accurate localization of outflow tract ventricular arrhythmia origin.

Heart Rhythm 2020 Jul 9. Epub 2020 Jul 9.

State Key Laboratory of Cardiovascular Disease, Cardiac Arrhythmia Center, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. Electronic address:

Background: The initial depolarization vector of outflow tract (OT) ventricular arrhythmia (VA) varies in different origins, which may help to predict OT-VA origin more accurately.

Objective: To develop a more accurate electrocardiographic (ECG) criterion for differentiating between left and right OT-VA origins.

Methods: We studied 275 patients with successful ablation in the right ventricular OT (RVOT; n =207) or left ventricular OT (LVOT; n =68) in development cohort. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.hrthm.2020.07.006DOI Listing
  • Page 1 of 36870