744 results match your criteria Cardiovascular diagnosis and therapy[Journal]


Nano fragility.

Authors:
Michal Gavish

Cardiovasc Diagn Ther 2020 Apr;10(2):386-387

Washington, DC, USA.

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http://dx.doi.org/10.21037/cdt.2019.10.08DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7225427PMC

Multimorbidity and cardiovascular disease: a perspective on low- and middle-income countries.

Cardiovasc Diagn Ther 2020 Apr;10(2):376-385

Department of Internal Medicine, University Hospital Zurich, University of Zurich, Zurich, Switzerland.

New and changing patterns of multimorbidity (MM), i.e., multiple concurrent acute or chronic diseases in a person, are emerging in low- and middle-income countries (LMICs). Read More

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http://dx.doi.org/10.21037/cdt.2019.09.09DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7225439PMC

Cardiovascular magnetic resonance imaging for structural heart disease.

Cardiovasc Diagn Ther 2020 Apr;10(2):361-375

St Vincent's Hospital Sydney, New South Wales, Australia.

Cardiovascular magnetic resonance (CMR) has increasingly become a powerful imaging technique over the past few decades due to increasing knowledge about clinical applications, operator experience and technological advances, including the introduction of high field strength magnets, leading to improved signal-to-noise ratio. Its success is attributed to the free choice of imaging planes, the wide variety of imaging techniques, and the lack of harmful radiation. Developments in CMR have led to the accurate evaluation of cardiac structure, function and tissues characterisation, so this non-invasive technique has become a powerful tool for a broad range of cardiac pathologies. Read More

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http://dx.doi.org/10.21037/cdt.2019.06.02DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7225443PMC

Cardiac arrhythmias in low- and middle-income countries.

Cardiovasc Diagn Ther 2020 Apr;10(2):350-360

The Cardiac Clinic, Department of Medicine, Groote Schuur Hospital and University of Cape Town, Cape Town, South Africa.

Many low- and middle-income countries (LMICs) are undergoing an epidemiological transition. With an improvement in socioeconomic conditions and an aging population, cardiovascular diseases (CVDs), like cardiac arrhythmias, are expected to increase in these countries. However, there are limited studies on the epidemiology and management of cardiac arrhythmias in LMICs. Read More

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http://dx.doi.org/10.21037/cdt.2019.09.21DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7225444PMC

A glimpse of hope: cardiac surgery in low- and middle-income countries (LMICs).

Cardiovasc Diagn Ther 2020 Apr;10(2):336-349

Hatter Institute for Cardiovascular Research in Africa, Department of Medicine, Faculty of Health Sciences, Groote Schuur Hospital, University of Cape Town, Cape Town, South Africa.

Currently, more than five times more people live in low- and middle-income countries (LMICs) than in high-income countries (HICs). As such, the downward trend in cardiac surgical needs in HICs reflects only the situation of one sixth of the world population while the vast majority living in LMICs has still no or limited access to life saving heart operations. In these countries, rheumatic heart disease (RHD) still accounts for a significant proportion of cardiac surgical needs. Read More

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http://dx.doi.org/10.21037/cdt.2019.11.03DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7225428PMC

Detection and management of arrhythmias in peripartum cardiomyopathy.

Cardiovasc Diagn Ther 2020 Apr;10(2):325-335

Hatter Institute for Cardiovascular Research in Africa, University of Cape Town, Cape Town, South Africa.

Peripartum cardiomyopathy (PPCM) is an idiopathic dilated cardiomyopathy, in which previously healthy women present with heart failure secondary to left ventricular (LV) systolic dysfunction during the last months of pregnancy or up to 5 months postpartum. PPCM occurs worldwide. The incidence seems to be increasing, possibly due to increasing awareness of the condition and diagnosis thereof. Read More

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http://dx.doi.org/10.21037/cdt.2019.05.03DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7225429PMC

Pulmonary hypertension in low- and middle-income countries with focus on sub-Saharan Africa.

Cardiovasc Diagn Ther 2020 Apr;10(2):316-324

Hatter Institute for Cardiovascular Research in Africa, Department of Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.

Pulmonary hypertension (PH) is a devastating, progressive disease with increasingly debilitating symptoms and usually shortened overall life expectancy. This article reviews the global epidemiology of PH with focus on low- and middle-income countries (LMICs) and sub-Sahara African in particular. Although left ventricular heart disease is the most common cause globally, the main contributing risk factors in LMICs are chronic infectious diseases especially human immunodeficiency virus (HIV) and schistosomiasis. Read More

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http://dx.doi.org/10.21037/cdt.2019.07.06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7225434PMC

Rheumatic heart disease: current status of diagnosis and therapy.

Cardiovasc Diagn Ther 2020 Apr;10(2):305-315

Division of Paediatric Cardiology, Department of Paediatrics, Red Cross Children's Hospital, University of Cape Town, Cape Town, South Africa.

Rheumatic heart disease (RHD) is the only preventable cardiovascular disease which causes significant morbidity and mortality particularly in low- and middle-income countries. Early clinical diagnosis is key, the updated Jones criteria increases the likelihood of diagnosis in endemic settings, including the echo diagnosis of sub-clinical carditis, polyarthralgia and monoarthritis as well as amended thresholds of minor criteria. The mainstay of rheumatic heart valve disease (RHVD) is a thorough clinical and echocardiographic investigation while severe disease is managed with medical, interventional and surgical treatment. Read More

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http://dx.doi.org/10.21037/cdt.2019.10.07DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7225445PMC

Circulating biomarkers in the early detection of hypertensive heart disease: usefulness in the developing world.

Cardiovasc Diagn Ther 2020 Apr;10(2):296-304

Soweto Cardiovascular Research Unit, University of Witwatersrand, Johannesburg, South Africa.

Although the varying phenotypic spectra of hypertensive heart disease (HHD) can be assessed by electrocardiography (ECG), echocardiography and cardiovascular magnetic resonance (CMR), ECG criteria for left ventricular hypertrophy (LVH) are insensitive, while echocardiography and CMR are expensive, less readily available and often lack requisite expertise. Consequently, the use of circulating biomarkers in the diagnosis and prognostication of HHD beyond the traditional N-terminal pro- b-type natriuretic peptide (NT-proBNP) and B-type natriuretic peptide (BNP) have become an attractive alternative. We carried out a PubMed and Google Scholar databases' search of original articles on circulating biomarkers used in the diagnosis of the different spectrum of HHD over the last 10 years [2005-2015] in humans. Read More

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http://dx.doi.org/10.21037/cdt.2019.09.10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7225418PMC

Tuberculous pericardial disease: a focused update on diagnosis, therapy and prevention of complications.

Cardiovasc Diagn Ther 2020 Apr;10(2):289-295

Division of Cardiology, Department of Medicine, University of Cape Town, Groote Schuur Hospital, Cape Town, South Africa.

Tuberculous pericarditis (TBP) is the most important manifestation of tuberculous heart disease and is still associated with a significant morbidity and mortality in TB endemic areas. The high prevalence of the disorder over the last 3 decades has been fueled by the human immunodeficiency virus/AIDS (HIV/AIDS) pandemic in these areas. The objective of this review is to provide a focused update on developments in the diagnosis and therapy of this condition, prevention of its complications, as well as future novel therapies. Read More

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http://dx.doi.org/10.21037/cdt.2019.09.20DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7225424PMC

Challenges in addressing the knowledge gap on endomyocardial fibrosis through community-based studies.

Cardiovasc Diagn Ther 2020 Apr;10(2):279-288

Instituto Nacional de Saúde, Maputo, Mozambique.

Endomyocardial fibrosis (EMF) is a poverty-related disease of unknown origin that afflicts predominantly young people of certain rural areas in low-income countries and can be used to expose global disparities in cardiovascular research. Despite affecting predominantly young people and causing high morbidity and mortality, efforts to understand its mechanisms and natural history have been hampered by the incapacity to detect the early stages of the disease in endemic areas. Dietary, environmental and infectious factors seem to combine in susceptible individuals to give rise to an inflammatory process that leads to endomyocardial damage and scar formation. Read More

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http://dx.doi.org/10.21037/cdt.2019.08.07DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7225430PMC

Genetics of inherited cardiomyopathies in Africa.

Cardiovasc Diagn Ther 2020 Apr;10(2):262-278

Cardiovascular Genetics Laboratory, Hatter Institute for Cardiovascular Research in Africa, Department of Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.

In sub-Saharan Africa (SSA), the burden of noncommunicable diseases (NCDs) is rising disproportionately in comparison to the rest of the world, affecting urban, semi-urban and rural dwellers alike. NCDs are predicted to surpass infections like human immunodeficiency virus, tuberculosis and malaria as the leading cause of mortality in SSA over the next decade. Heart failure (HF) is the dominant form of cardiovascular disease (CVD), and a leading cause of NCD in SSA. Read More

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http://dx.doi.org/10.21037/cdt.2019.10.03DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7225421PMC

Infective endocarditis in South Africa.

Cardiovasc Diagn Ther 2020 Apr;10(2):252-261

Division of Cardiology, Department of Medicine, Stellenbosch University and Tygerberg Hospital, Cape Town, South Africa.

Infective endocarditis (IE) is defined by infection of either a native or prosthetic heart valve, endocardial surface or any cardiac prosthetic device. It is a disease of both the developed and developing world, although IE has evolved in the developed world to a disease markedly different to the disease encountered in the developing world. IE in developed nations is mainly a disease of older patients with degenerative heart valve disease or cardiac prosthetic material, with virulent Staphylococci the most common causative organism. Read More

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http://dx.doi.org/10.21037/cdt.2019.06.03DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7225416PMC

An overview of heart failure in low- and middle-income countries.

Cardiovasc Diagn Ther 2020 Apr;10(2):244-251

Division of Cardiology, Department of Medicine, University of Cape Town and Groote Schuur Hospital, Cape Town, South Africa.

Heart failure (HF) is a global public health concern with disproportionate socioeconomic, morbidity and mortality burden on low- and middle-income countries (LMICs). This review summarises contemporary data on the demographic and clinical characteristics, aetiologies, treatment, economic burden and outcomes of HF in LMICs. Patients with HF in LMICs are younger than those from high-income countries (HICs) and present at advanced stages of the disease. Read More

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http://dx.doi.org/10.21037/cdt.2019.08.03DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7225422PMC

An 'asymptomatic' driver with COVID-19: atypical suspected myocarditis by SARS-CoV-2.

Cardiovasc Diagn Ther 2020 Apr;10(2):242-243

Department of Radiology, The Second Affiliated Hospital of Kunming Medical University, Kunming 650101, China.

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http://dx.doi.org/10.21037/cdt.2020.03.08DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7225419PMC

Pulmonary artery sarcoma feigning pulmonary thromboembolism.

Cardiovasc Diagn Ther 2020 Apr;10(2):236-238

Department of Cardiovascular Medicine, The Second Xiangya Hospital, Central South University, Changsha 410011, China.

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http://dx.doi.org/10.21037/cdt.2020.03.03DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7225431PMC

Automated detection of cardiovascular disease by electrocardiogram signal analysis: a deep learning system.

Cardiovasc Diagn Ther 2020 Apr;10(2):227-235

Department of Medical Informatics, School of Biomedical Engineering and Informatics, Nanjing Medical University, Nanjing 211166, China.

Automated electrocardiogram (ECG) diagnosis could be a useful aid for clinical use. We applied a deep learning method to build a system for automated detection and classification of ECG signals. We first trained a convolutional neural network (CNN) to detect cardiovascular disease in ECG signals using a training data set of 259,789 ECG signals collected from the cardiac function rooms of a tertiary care hospital. Read More

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http://dx.doi.org/10.21037/cdt.2019.12.10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7225435PMC

Transcatheter aortic valve implantation in the presence of an anomalous left circumflex coronary artery: a case report.

Cardiovasc Diagn Ther 2020 Apr;10(2):223-226

Minneapolis Veterans Affairs Medical Center, Minneapolis, MN, USA.

This is a case of an anomalous left circumflex coronary artery (LCX) originating from the right coronary cusp with a retroaortic course in a patient with severe aortic valve stenosis requiring transcatheter aortic valve implantation (TAVI). In the context of TAVI, an anomalous LCX has been described only in a few case reports. In some, the LCX remains unaffected. Read More

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http://dx.doi.org/10.21037/cdt.2020.03.05DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7225423PMC

Endomyocardial fibrosis.

Cardiovasc Diagn Ther 2020 Apr;10(2):208-222

Department of Cardiovascular Surgery, Second Xiangya Hospital, Central South University, Changsha 410011, China.

Background: Endomyocardial fibrosis (EMF) is a neglected cardiovascular disease of poverty which carries a poor prognosis with no specific treatment affecting mainly children and young adults. Here, we report our 10-year experience in the therapeutic management and surgical treatment for EMF.

Methods: From February 2009 to 2019 March, 55 patients diagnosed with EMF from our cardiology unit underwent surgical repair at our department's pediatric surgical division. Read More

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http://dx.doi.org/10.21037/cdt.2020.02.10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7225420PMC

Screening CT angiography in patients with suspected fibromuscular dysplasia: improved patient care with single-session skull vertex to pelvis coverage.

Cardiovasc Diagn Ther 2020 Apr;10(2):201-207

Imaging Institute, Cleveland Clinic, Cleveland, OH, USA.

Background: Imaging plays a key role in the workup of patients with clinically suspected fibromuscular dysplasia (FMD), and research has highlighted the potential of computed tomography angiography (CTA) in screening for thoracic, abdominal, and pelvic arterial abnormalities in these patients. We sought to evaluate imaging findings from patients with suspected or diagnosed FMD who underwent screening CTA at our institution with a novel single-acquisition protocol that offers increased anatomic coverage, with images obtained from the skull vertex to the pelvis.

Methods: Images from 80 consecutive patients scanned with the novel single-session CTA protocol covering the skull vertex to the pelvis were compared with images from 20 additional consecutive patients who underwent CTA for the head and neck separate from CTA of the chest, abdomen, and pelvis. Read More

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http://dx.doi.org/10.21037/cdt.2020.02.06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7225442PMC

Patients with hypertrophic obstructive cardiomyopathy after alcohol septal ablation have favorable long-term outcome irrespective of their genetic background.

Cardiovasc Diagn Ther 2020 Apr;10(2):193-200

Department of Cardiology, 2nd Faculty of Medicine, Charles University and Motol University Hospital, Prague, Czech Republic.

Background: The genetic background of patients with hypertrophic cardiomyopathy (HCM) treated with alcohol septal ablation (ASA) and its relationship to the outcomes are not known. We aimed to investigate whether the outcome of genotype positive (G+) patients differs from genotype negative (G-) patients treated with ASA.

Methods: We included 129 HCM patients (mean age 54±13 years) treated with ASA in a tertiary cardiovascular center and performed next generation sequencing (NGS) based genomic testing. Read More

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http://dx.doi.org/10.21037/cdt.2020.01.12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7225433PMC

Effects of myocardial viability and left ventricular remodeling on survival of patients with heart failure and reduced ejection fraction after coronary artery bypass grafting.

Cardiovasc Diagn Ther 2020 Apr;10(2):183-192

Department of Cardiac Surgery, Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China.

Background: Heart failure with reduced ejection fraction (HFrEF) caused by coronary heart disease (CHD) accounts for the largest proportion of patients with heart failure and is associated with the poorest prognosis. However, date on the perioperative risk and long-term survival of patients with HFrEF are limited. The present study aimed at exploring the effects of the left ventricular end-systolic volume index (LVESVI) and myocardial viability on perioperative risk and long-term survival after coronary artery bypass grafting (CABG) in patients with HFrEF. Read More

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http://dx.doi.org/10.21037/cdt.2020.01.11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7225425PMC

Intra- and inter-observer reproducibility of multilayer cardiac magnetic resonance feature tracking derived longitudinal and circumferential strain.

Cardiovasc Diagn Ther 2020 Apr;10(2):173-182

Faculty of Medicine, University of New South Wales, Bossley Park, Sydney, NSW, Australia.

Background: Multilayer strain measurement with cardiac magnetic resonance feature tracking (CMR-FT) allows independent assessment of endocardial and epicardial strain. This novel method of layer-specific quantification of myocardial deformation parameters provides greater insight into contractility compared to whole-layer strain analysis. The clinical utility of this technique is promising. Read More

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http://dx.doi.org/10.21037/cdt.2020.01.10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7225436PMC

The prognostic value of right ventricular deformation derived from cardiac magnetic resonance tissue tracking for all-cause mortality in light-chain amyloidosis patients.

Cardiovasc Diagn Ther 2020 Apr;10(2):161-172

MR Collaboration, Siemens Healthcare Ltd., Shanghai 201318, China.

Background: Early detection of right ventricular (RV) dysfunction is vital for determining the prognosis of light-chain amyloidosis (AL) patients. While few studies focused on RV deformation due to the limitation of research methods. The aim of this study was to determine the prognostic significance of RV myocardial strain in AL patients assessed by cardiac magnetic resonance (CMR) tissue tracking. Read More

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http://dx.doi.org/10.21037/cdt.2020.01.03DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7225432PMC

Ginsenoside Rg3 protects heart against isoproterenol-induced myocardial infarction by activating AMPK mediated autophagy.

Cardiovasc Diagn Ther 2020 Apr;10(2):153-160

Department of Cardiology, The Fourth Affiliated Hospital of Harbin Medical University, Harbin 150001, China.

Background: Panax ginseng is a well-known medicinal herb that is widely used in traditional Chinese medicine for treating various diseases. Ginsenoside Rg3 (Rg3) is thought to be one of the most important active ingredients of Panax ginseng. However, the molecular mechanism underlying the beneficial effects of Rg3 has been elusive. Read More

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http://dx.doi.org/10.21037/cdt.2020.01.02DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7225426PMC

Soluble ST2, Galectin-3 and clinical prognosis of patients with hypertrophic cardiomyopathy undergoing ventricular septal myectomy: a correlation analysis.

Cardiovasc Diagn Ther 2020 Apr;10(2):145-152

Department of Cardiac Surgery, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China.

Background: Hypertrophic cardiomyopathy (HCM) is the most common chromosomal abnormal heart disease. The pathophysiological mechanism of HCM is complex. Several studies have suggested that the level of Soluble ST2 (sST2) may be a biomarker of chronic systolic heart failure, however, the role of sST2 in HCM remains unclear. Read More

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http://dx.doi.org/10.21037/cdt.2020.01.04DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7225438PMC

Comparison of surgical versus transcatheter aortic valve replacement for patients with aortic stenosis at low-intermediate risk.

Cardiovasc Diagn Ther 2020 Apr;10(2):135-144

Section of Cardiology, Department of Internal Medicine, Baylor College of Medicine, Houston, TX, USA.

Background: To compare safety and efficacy of transcatheter aortic valve replacement (TAVR) with surgical aortic valve replacement (SAVR) in patients at low-intermediate risk, given the paucity of robust data.

Methods: We performed an aggregate data meta-analysis of 7 randomized controlled trials (RCTs) and 6,778 patients comparing TAVR with SAVR for aortic stenosis (AS) in low-intermediate risk patients (Society of Thoracic Surgeons risk-score ≤8%) using the random-effects model. Primary outcome was all-cause mortality at 30-day, 1-year and 2-year of follow-up. Read More

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http://dx.doi.org/10.21037/cdt.2020.02.11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7225446PMC

Validation of black blood late gadolinium enhancement (LGE) for evaluation of myocardial infarction in patients with or without pathological Q-wave on electrocardiogram (ECG).

Cardiovasc Diagn Ther 2020 Apr;10(2):124-134

Department of Epidemiology and Biostatistics, School of Public Health, Kunming Medical University, Kunming 650500, China.

Background: The pathological Q-wave (QW) is an important indicator of infarcted myocardial volume indicating a worse prognosis compared to non-Q-wave (NQW) infarctions. Traditional classification divides infarcts into transmural and non-transmural based on QW and NQW. This view has been challenged by the advent of late gadolinium enhancement (LGE) MR imaging. Read More

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http://dx.doi.org/10.21037/cdt.2019.12.11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7225441PMC

Kallistatin correlates with inflammation in abdominal aortic aneurysm and suppresses its formation in mice.

Cardiovasc Diagn Ther 2020 Apr;10(2):107-123

Department of Vascular Surgery, The First Hospital of China Medical University, Shenyang 110001, China.

Background: Kallistatin (KS), encoded by , was suggested to play a protective role in many cardiovascular diseases. However, its role in the pathogenesis of abdominal aortic aneurysm (AAA) remains unclear. The aim of this study was to examine the potential association of KS with AAA pathogenesis. Read More

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http://dx.doi.org/10.21037/cdt.2019.12.08DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7225437PMC

Iliofemoral lysis for DVT remains ATTRACTive.

Cardiovasc Diagn Ther 2020 Apr;10(2):104-106

Division of Vascular Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.

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http://dx.doi.org/10.21037/cdt.2019.08.08DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7225440PMC

Emergent technique in watercolor.

Authors:
Emily Garfield

Cardiovasc Diagn Ther 2020 Feb;10(1):101-103

SciArt Center, New York, USA.

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http://dx.doi.org/10.21037/cdt.2019.04.04DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7044102PMC
February 2020

Training in structural heart disease: a fellow's perspective.

Cardiovasc Diagn Ther 2020 Feb;10(1):98-100

Division of Cardiology, Duke University Medical Center, Durham, NC, USA.

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http://dx.doi.org/10.21037/cdt.2019.07.05DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7044093PMC
February 2020

Current state of transcatheter tricuspid valve repair.

Cardiovasc Diagn Ther 2020 Feb;10(1):89-97

Division of Cardiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.

Tricuspid regurgitation (TR) is a common valvular heart disease affecting >1.6 million people in the United States (US) and >70 million people worldwide. The age- and sex-adjusted prevalence of more than or equal to moderate TR in the US is estimated to be 0. Read More

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http://dx.doi.org/10.21037/cdt.2019.09.11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7044094PMC
February 2020

Current status of transcatheter aortic valve replacement in India.

Cardiovasc Diagn Ther 2020 Feb;10(1):83-88

Fortis Escorts Heart Institute, New Delhi, India.

Transcatheter aortic valve replacement (TAVR) has proven to be the cornerstone therapy for patients with severe aortic stenosis (AS). India is currently overburdened with AS, both rheumatic and non-rheumatic. Although TAVR has revolutionized the treatment of non-rheumatic AS it does offer a ray of hope for rheumatic AS in future. Read More

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http://dx.doi.org/10.21037/cdt.2019.05.04DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7044098PMC
February 2020

Review of alternative access in transcatheter aortic valve replacement.

Cardiovasc Diagn Ther 2020 Feb;10(1):72-82

Divisions of Cardiology, Duke University Medical Center, Durham, North Carolina, USA.

Transcatheter aortic valve replacement (TAVR) has surpassed surgical aortic valve replacement (SAVR) as the most common treatment strategy for severe symptomatic aortic stenosis over the past decade. As TAVR technology has continued to advance, it has been expanded from being an option only for extreme risk patients to now being the preferred option for the majority of patients with severe aortic stenosis. Recent trials have shown that TAVR is superior or non-inferior to SAVR even in patients at low surgical risk. Read More

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http://dx.doi.org/10.21037/cdt.2019.10.01DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7044091PMC
February 2020

Transcatheter aortic valve replacement in low risk patients: a review of PARTNER 3 and Evolut low risk trials.

Cardiovasc Diagn Ther 2020 Feb;10(1):59-71

Cardiovascular Division, Department of Medicine, University of Miami Miller School of Medicine and the Elaine and Sydney Sussman Cardiac Catheterization Laboratory, University of Miami Hospitals and Clinics, Miami, Florida, USA.

Transcatheter aortic valve replacement (TAVR) has become a mainstay in treatment for patients with severe aortic stenosis who are considered high-risk surgical candidates. The use of TAVR in low-risk patients with severe aortic stenosis is being explored as an alternative to surgical aortic valve replacement (SAVR). Recent results from the Medtronic Evolut Low Risk trial and the Placement of Aortic Transcatheter Valves (PARTNER) 3 trial shed light on the use of TAVR in low-risk surgical candidates. Read More

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http://dx.doi.org/10.21037/cdt.2019.09.12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7044101PMC
February 2020

Role of CT imaging in left atrial appendage occlusion for the WATCHMAN™ device.

Cardiovasc Diagn Ther 2020 Feb;10(1):45-58

Center for Structural Heart Disease, Division of Cardiology, Henry Ford Health System, Detroit, Michigan, USA.

Computed tomography (CT) plays a key role in the peri-procedural planning of left atrial appendage occlusion (LAAO) device placement and post-procedural evaluation. The geometric variability of the interatrial septum, left atrium, and the left atrial appendage morphology can be fully visualized and intuitively appreciated through CT-derived, patient-specific 3D model unique to each individual's anatomy. This review further defines the strengths and limitations of CT peri-procedural imaging in the planning of LAAO. Read More

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http://dx.doi.org/10.21037/cdt.2019.12.01DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7044092PMC
February 2020

Current state of the roles of alcohol septal ablation and surgical myectomy in the treatment of hypertrophic obstructive cardiomyopathy.

Authors:
John S Douglas

Cardiovasc Diagn Ther 2020 Feb;10(1):36-44

Division of Cardiology, Emory University School of Medicine, Emory University Hospital, Atlanta, Georgia, USA.

Hypertrophic cardiomyopathy is a genetically determined disorder resulting in left ventricular hypertrophy. In a majority of the estimated 20 million people affected worldwide, left ventricular outflow obstruction is present at rest or with provocation. The presence and degree of obstruction influence the symptomatic presentation, treatment strategies and prognosis of affected individuals. Read More

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http://dx.doi.org/10.21037/cdt.2019.07.02DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7044100PMC
February 2020

Impact of paroxysmal versus non-paroxysmal atrial fibrillation on outcomes in patients undergoing transcatheter mitral valve repair.

Cardiovasc Diagn Ther 2020 Feb;10(1):31-35

Division of Cardiology, University of North Carolina, Chapel Hill, NC, USA.

Background: To study the impact of type of atrial fibrillation on outcomes following transcatheter mitral valve repair. The development of atrial fibrillation (AF) in degenerative mitral regurgitation (MR) can be a sign of progression of MR and associated with adverse outcomes. However, the impact of type of AF in patients undergoing transcatheter mitral valve (MV) repair remains uncertain. Read More

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http://dx.doi.org/10.21037/cdt.2019.08.06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7044103PMC
February 2020

Progression in the severity of aortic stenosis according to race among those with advanced chronic kidney disease.

Cardiovasc Diagn Ther 2020 Feb;10(1):24-30

Division of Cardiology, Gillings School of Public Health, University of North Carolina, Chapel Hill, NC, USA.

Background: There is a higher prevalence of aortic stenosis (AS) in patients with advanced chronic kidney disease (CKD) and European ancestry. However, studies comparing AS progression in white and black patients in an advanced CKD population do not exist.

Methods: Advanced CKD (stage IV-V) patients who were referred to the UNC Cardiorenal Clinic for pre-operative kidney transplant evaluation, and diagnosed with either AS (mild, moderate, or severe) or a left ventricular outflow tract velocity ≥2 m/s at any point between 2006-2016 were eligible for inclusion. Read More

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http://dx.doi.org/10.21037/cdt.2019.06.04DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7044097PMC
February 2020

Prognostic impact of myocardial contraction fraction in patients undergoing transcatheter aortic valve replacement for aortic stenosis.

Cardiovasc Diagn Ther 2020 Feb;10(1):12-23

Division of Interventional Cardiology, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina.

Background: Myocardial contraction fraction (MCF), a volumetric measurement of myocardial shortening, may help to improve risk stratification in patients with severe aortic stenosis (AS) referred for transcatheter aortic valve replacement (TAVR) especially in those with preserved left ventricular ejection fraction (LVEF). We investigated the association between MCF and 1-year all-cause mortality in patients with severe AS who underwent TAVR.

Methods: MCF was calculated as the ratio of stroke volume (SV) to myocardial volume. Read More

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http://dx.doi.org/10.21037/cdt.2019.05.02DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7044096PMC
February 2020

Trends and effect of atrial fibrillation on inpatient outcomes after transcatheter aortic valve replacement.

Cardiovasc Diagn Ther 2020 Feb;10(1):3-11

Division of Cardiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

Background: Atrial fibrillation (AF) is common in patients undergoing transcatheter aortic valve replacement (TAVR) but there is conflicting evidence on whether AF impacts outcomes after TAVR.

Methods: Hospitalizations of adults ≥50 years old who had undergone elective TAVR from 2012 to 2015 were included. Poisson regression was used to assess changes in in-hospital complications, average length of stay (LOS) after TAVR, and discharge disposition over time. Read More

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http://dx.doi.org/10.21037/cdt.2019.05.05DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7044095PMC
February 2020

Percutaneous structural and valvular heart disease interventions.

Cardiovasc Diagn Ther 2020 Feb;10(1):1-2

Cardiovascular Disease Fellow, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

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http://dx.doi.org/10.21037/cdt.2020.01.01DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7044099PMC
February 2020

Renal denervation for hypertension: we've come a long way!

Cardiovasc Diagn Ther 2019 Dec;9(6):607-608

Division of Cardiology, Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA.

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http://dx.doi.org/10.21037/cdt.2019.09.15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6987507PMC
December 2019

Installations, video works, paintings.

Authors:
Mark Maxwell

Cardiovasc Diagn Ther 2019 Dec;9(6):613-615

London, UK.

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http://dx.doi.org/10.21037/cdt.2019.09.17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6987513PMC
December 2019

Out-of-hospital cardiopulmonary resuscitation: a position statement of the Lebanese Society of Cardiology and the Lebanese Society of Emergency Medicine.

Cardiovasc Diagn Ther 2019 Dec;9(6):609-612

Emergency Medical Services and Prehospital Care, Department of Emergency Medicine, American University of Beirut Medical Center, Beirut, Lebanon.

Out of hospital cardiac arrest (OHCA) is a leading cause of death worldwide. Early cardiopulmonary resuscitation (CPR) and early defibrillation are key to improving outcomes of patients with OHCA including return of spontaneous circulation (ROSC) and survival to hospital discharge with good neurologic outcomes. Lebanon like other developing countries, suffers from absence of organized prehospital cardiac arrest care bundle and from absence of a legal framework for community involvement in cardiac arrest care. Read More

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http://dx.doi.org/10.21037/cdt.2019.11.04DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6987508PMC
December 2019

Shaping the future of renal denervation-the relevance of sham-controlled randomized trials and recent meta-analyses.

Cardiovasc Diagn Ther 2019 Dec;9(6):601-606

Dobney Hypertension Centre, School of Medicine-Royal Perth Hospital Unit/Medical Research Foundation, The University of Western Australia, Perth, Australia.

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http://dx.doi.org/10.21037/cdt.2019.07.03DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6987509PMC
December 2019

Intraluminal fibrous cord of the aorta in the differential diagnosis of aortic dissection.

Cardiovasc Diagn Ther 2019 Dec;9(6):596-600

Department of Radiology, Tianjin Medical University General Hospital, Tianjin 300052, China.

A patient presented with an intraluminal fibrous cord in the distal segment of ascending aorta. On axial images, the fibrous cord had the appearance of an aortic dissection flap. Observation of continuous images and multiplanar reconstruction were critical for differential diagnosis. Read More

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http://dx.doi.org/10.21037/cdt.2019.11.05DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6987512PMC
December 2019

Comparison of long-term outcomes of medical therapy and successful recanalisation for coronary chronic total occlusions in elderly patients: a report of 1,294 patients.

Cardiovasc Diagn Ther 2019 Dec;9(6):586-595

Department of Cardiology, the First Affiliated Hospital of Dalian Medical University, Dalian 116044, China.

Background: Little is known about the long-term outcomes of medical therapy (MT) versus successful percutaneous coronary intervention (PCI) in elderly patients with coronary chronic total occlusions (CTOs).

Methods: There were 1,294 consecutive patients with 1,520 CTOs included (2007 to 2016) and were divided into the younger group (age <65 years; n=664, 51.3%) and the older group (age ≥65 years; n=630, 48. Read More

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http://dx.doi.org/10.21037/cdt.2019.11.01DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6987515PMC
December 2019