Tetrahydrobiopterin (BH4 ): Targeting endothelial Nitric Oxide Synthase as a potential therapy for Pulmonary Hypertension.
Cardiovasc Ther 2017 Nov 19. Epub 2017 Nov 19.
Department of Internal Medicine B, Ziv Medical Center, Faculty of Medicine in the Galilee, Bar-Ilan University, Henrietta Szold st. 8, POB 1589, Safed, Israel.
Purpose: Pulmonary Hypertension (PH) is complex disease which is associated with endothelial and cardiac dysfunction. Tetrahydrobiopterin (BH4 ) regulates endothelial nitric oxide synthase (eNOS) to produce nitric oxide rather than superoxide which maintains normal endothelial and cardiac function. This study explores the therapeutic potential of BH4 in experimental PH. Read More