Vascular dysfunction elicited by a crosstalk between periaortic adipose tissue and the vascular wall is reversed by pioglitazone.
- Isabel Quesada,
- Jimena Cejas,
- Rodrigo García,
- Beatriz Cannizzo,
- Analía Redondo,
- Claudia Castro
Cardiovasc Ther 2018 Feb 21. Epub 2018 Feb 21.
Vascular Biology Lab, Institute of Experimental Medicine and Biology of Cuyo (IMBECU) CONICET and School of Medical Sciences, National University of Cuyo, Mendoza, Argentina.
Aim: Perivascular adipose tissue (PVAT) is in intimate contact with the vessel wall and extravascular PVAT-derived inflammatory mediators may adversely influence atherosclerotic plaque formation and stability through outside-to-inside signalling. We sought to investigate the role of PVAT on the atheroma development in an experimental animal model of Metabolic Syndrome (MS) associated with oxidative stress and low-grade inflammatory state. We also studied the effect of Pioglitazone an insulin sensitizer, on the aortic wall and its surrounding PVAT, considering a bi-directional communication between both layers. Read More