681 results match your criteria Cardiovascular Therapeutics[Journal]


Long Noncoding RNA TUG1 Promotes the Function in ox-LDL-Treated HA-VSMCs via miR-141-3p/ROR2 Axis.

Cardiovasc Ther 2020 29;2020:6758934. Epub 2020 May 29.

Department of Cardiology, People's Hospital of Jiangxi Province, 330002, Nanchang, China.

Background: Atherosclerosis (AS) is a common severe disease around the world. The merging paper reported that long noncoding RNAs (lncRNAs) took part in diversified pathological processes of AS, although the mechanism remains unknown. This study is aimed at uncovering the profile of lncRNA taurine-upregulated gene 1 (TUG1), which has biological function, and potential mechanism in AS progression . Read More

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http://dx.doi.org/10.1155/2020/6758934DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7285414PMC

Identification of Target Genes of Antiarrhythmic Traditional Chinese Medicine Wenxin Keli.

Cardiovasc Ther 2020 27;2020:3480276. Epub 2020 May 27.

Department of Cardiovascular Diseases, The First Affiliated Hospital of Guangdong Pharmaceutical University, Guangzhou, Guangdong 510080, China.

Wenxin Keli (WXKL) is a traditional Chinese medicine drug approved for the treatment of cardiovascular diseases. This study aimed to identify WXKL-targeting genes involved in antiarrhythmic efficacy of WXKL. The Traditional Chinese Medicine Systems Pharmacology (TCMSP) technology platform was used to screen active compounds of WXKL and WXKL-targeting arrhythmia-related genes. Read More

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http://dx.doi.org/10.1155/2020/3480276DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7284932PMC

Drug Use Evaluation of Beta-Blockers in Medical Wards of Nedjo General Hospital, Western Ethiopia.

Cardiovasc Ther 2020 22;2020:2509875. Epub 2020 May 22.

Department of Pharmaceutical Sciences, University of Kashmir, Hazratbal Srinagar, 190006 Jammu and Kashmir, India.

Introduction: Beta-blocker use evaluation is a performance method that focuses on the evaluation of beta-blocker use processes to achieve optimal patient outcomes. Several studies conducted in different hospitals revealed a high incidence of inappropriate prescription of beta-blockers among hospitalized patients. Therefore, it is important to identify inappropriate beta-blocker prescribing since they may increase the risk of hospitalizations. Read More

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http://dx.doi.org/10.1155/2020/2509875DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7284961PMC

Determinants of Selected Cardiovascular Diseases among Adult Patients at Cardiac Clinic of Debre Berhan Referral Hospital, Ethiopia: Unmatched Case-Control Study.

Cardiovasc Ther 2020 19;2020:7036151. Epub 2020 May 19.

Department of English, College of Social Sciences, Debre Berhan University, Debre Berhan, Ethiopia.

Background: Africans are experiencing a rapid epidemiological transition characterized by urbanization and lifestyle changes, which are thought to contribute to increased incidence and prevalence of cardiovascular diseases (CVDs) in many African countries, including Ethiopia. Despite this, however, there is scarcity of evidence on cardiovascular disease risk factors among adults in the current research setting. This study thus aimed at assessing determinants of selected cardiovascular diseases among adult patients at Debre Berhan Referral Hospital (DBRH). Read More

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http://dx.doi.org/10.1155/2020/7036151DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7273416PMC

Platelet Responses in Cardiovascular Disease: Sex-Related Differences in Nutritional and Pharmacological Interventions.

Cardiovasc Ther 2020 19;2020:2342837. Epub 2020 May 19.

Department of Experimental Medicine, Tor Vergata University of Rome, Rome 00133, Italy.

Cardiovascular diseases (CVD) represent one of the biggest causes of death globally, and their prevalence, aetiology, and outcome are related to genetic, metabolic, and environmental factors, among which sex- and age-dependent differences may play a key role. Among CVD risk factors, platelet hyperactivity deserves particular mention, as it is involved in the pathophysiology of main cardiovascular events (including stroke, myocardial infarction, and peripheral vascular injury) and is closely related to sex/age differences. Several determinants (, hormonal status and traditional cardiovascular risk factors), together with platelet-related factors (, plasma membrane composition, receptor signaling, and platelet-derived microparticles) can elucidate sex-related disparity in platelet functionality and CVD onset and outcome, especially in relation to efficacy of current primary and secondary interventional strategies. Read More

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http://dx.doi.org/10.1155/2020/2342837DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7273457PMC

Long Noncoding RNA SOX2-OT Exacerbates Hypoxia-Induced Cardiomyocytes Injury by Regulating miR-27a-3p/TGFR1 Axis.

Cardiovasc Ther 2020 6;2020:2016259. Epub 2020 May 6.

Department of Medical Service, Tianjin Union Medical Center, Tianjin 300121, China.

Background: Myocardial infarction (MI) was a severe cardiovascular disease resulted from acute, persistent hypoxia, or ischemia condition. Additionally, MI generally led to heart failure, even sudden death. A multitude of research studies proposed that long noncoding RNAs (lncRNAs) frequently participated in the regulation of heart diseases. Read More

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http://dx.doi.org/10.1155/2020/2016259DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7262654PMC

Is Extra Virgin Olive Oil an Ally for Women's and Men's Cardiovascular Health?

Cardiovasc Ther 2020 24;2020:6719301. Epub 2020 Apr 24.

Laboratorio PHYTOLAB (Pharmaceutical, Cosmetic, Food Supplement Technology and Analysis), DiSIA Università Degli Studi di Firenze, 50019 Florence, Italy.

Noncommunicable diseases are long-lasting and slowly progressive and are the leading causes of death and disability. They include cardiovascular diseases (CVD) and diabetes mellitus (DM) that are rising worldwide, with CVD being the leading cause of death in developed countries. Thus, there is a need to find new preventive and therapeutic approaches. Read More

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http://dx.doi.org/10.1155/2020/6719301DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7212338PMC

Cardioprotective Effect of ()-2-Acetoxy-3-(3,4-Dihydroxyphenyl) Acrylic Acid: Inhibition of Apoptosis in Cardiomyocytes.

Cardiovasc Ther 2020 29;2020:8584763. Epub 2020 Apr 29.

Department of Cardiac Surgery, Zhongshan Hospital, Fudan University, No. 180, Fenglin Road, Shanghai 200032, China.

Background: Although many studies have been performed to elucidate the molecular mechanisms of heart failure, an effective pharmacological therapy to protect cardiac tissues from severe loss of contractile function associated with heart failure after acute myocardial infarction (MI) has yet to be developed.

Methods: We examined the cardioprotective effects of ()-2-acetoxy-3-(3,4-dihydroxyphenyl) acrylic acid, a new compound with potent antioxidant and antiapoptotic activities in a rat model of heart failure. ()-2-Acetoxy-3-(3,4-dihydroxyphenyl) acrylic acid was systemically delivered to rats 6 weeks after MI at different doses (15, 30, and 60 mg/kg). Read More

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http://dx.doi.org/10.1155/2020/8584763DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7211238PMC

Association between Serum Vitamin C and the Blood Pressure: A Systematic Review and Meta-Analysis of Observational Studies.

Cardiovasc Ther 2020 29;2020:4940673. Epub 2020 Apr 29.

College of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China.

Background: Hypertension is regarded as a major and independent risk factor of cardiovascular diseases, and numerous studies observed an inverse correlation between vitamin C intake and blood pressure.

Aim: Our aim is to investigate the relationship between serum vitamin C and blood pressure, including the concentration differences and the correlation strength.

Method: Two independent researchers searched and screened articles from the National Library of Medicine, Cochrane Library, Web of Science, China National Knowledge Infrastructure, VIP databases, and WANFANG databases. Read More

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http://dx.doi.org/10.1155/2020/4940673DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7211237PMC

-Adrenoceptors: Challenges and Opportunities-Enlightenment from the Kidney.

Cardiovasc Ther 2020 29;2020:2478781. Epub 2020 Apr 29.

University of Pittsburgh School of Medicine, Department of Pharmacology and Chemical Biology, 100 Technology Drive, Room 514, Pittsburgh, PA 15219, USA.

It was indeed a Don Quixote-like pursuit of the mechanism of essential hypertension when we serendipitously discovered -adrenoceptors (-ARs) in skin-lightening experiments in the frog. Now -ARs lurk on the horizon involving hypertension causality, renal denervation for hypertension, injury from falling in the elderly and prazosin's mechanism of action in anxiety states such as posttraumatic stress disorder (PTSD). Our goal here is to focus on this horizon and bring into clear view the role of -AR-mediated mechanisms in these seemingly unrelated conditions. Read More

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http://dx.doi.org/10.1155/2020/2478781DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7211234PMC

Angiographic Restenosis in Coronary Bifurcations Treatment with Regular Drug Eluting Stents and Dedicated Bifurcation Drug-Eluting BiOSS Stents: Analysis Based on Randomized POLBOS I and POLBOS II Studies.

Cardiovasc Ther 2020 21;2020:6760205. Epub 2020 Jan 21.

Cardiovascular Institute, Mount Sinai Medical Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Aim: The marked variation in bifurcation anatomy has brought about an ongoing search for stents specifically constructed for coronary bifurcations. This study aimed to analyze the angiographic restenosis prevalence and patterns and predictors of different patterns in dedicated bifurcation BiOSS® vs. current generation drug-eluting stents implanted in coronary bifurcation lesions based on data from two clinical trials POLBOS I and II. Read More

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http://dx.doi.org/10.1155/2020/6760205DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7204374PMC
January 2020

Comparative Lipid-Lowering/Increasing Efficacy of 7 Statins in Patients with Dyslipidemia, Cardiovascular Diseases, or Diabetes Mellitus: Systematic Review and Network Meta-Analyses of 50 Randomized Controlled Trials.

Cardiovasc Ther 2020 23;2020:3987065. Epub 2020 Apr 23.

Department of Pharmacy, Base for Clinical Trial, Peking University First Hospital, Beijing 100034, China.

Objective: The drug efficacy may differ among different statins, and evidence from head-to-head comparisons is sparse and inconsistent. The study is aimed at comparing the lipid-lowering/increasing effects of 7 different statins in patients with dyslipidemia, cardiovascular diseases, or diabetes mellitus by conducting systematic review and network meta-analyses (NMA) of the lipid changes after certain statins' use.

Methods: In this study, we searched four electronic databases for randomized controlled trials (RCTs) published through February 25, 2020, comparing the lipid-lowering efficacy of no less than two of the included statins (or statin vs. Read More

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http://dx.doi.org/10.1155/2020/3987065DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7201823PMC
April 2020
2.362 Impact Factor

Left Ventricular Ejection Fraction Is Associated with the Risk of Thrombus in the Left Atrial Appendage in Patients with Atrial Fibrillation.

Cardiovasc Ther 2020 24;2020:3501749. Epub 2020 Apr 24.

1st Chair and Department of Cardiology, Medical University of Warsaw, Warsaw, Poland.

Introduction: Atrial fibrillation (AF) is associated with high risk of ischemic stroke. The most frequent thrombus location in AF is the left atrial appendage (LAA). Transthoracic echocardiography (TTE) is a basic diagnostic examination in patients (pts) with AF. Read More

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http://dx.doi.org/10.1155/2020/3501749DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7201491PMC

Drug-Coated Balloons versus Everolimus-Eluting Stents in Patients with In-Stent Restenosis: A Pair-Wise Meta-Analysis of Randomized Trials.

Cardiovasc Ther 2020 21;2020:1042329. Epub 2020 Jan 21.

Department of Internal Medicine, Guizhou Orthopedics Hospital, Guiyang, China.

Objective: This study aimed to compare the effectiveness of drug-coated balloons (DCB) with everolimus-eluting stents (EES) in the treatment of in-stent restenosis (ISR) and the differential relative effect of DCB in patients with drug-eluting stents (DES)-ISR and bare metal stents (BMS)-ISR.

Background: The efficiency and safety of DCB and EES need to be assessed for the treatment of ISR.

Methods: A systematic literature search was conducted using PubMed and EMBASE to identify all relevant studies. Read More

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http://dx.doi.org/10.1155/2020/1042329DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7204349PMC
January 2020

Therapeutic Anticoagulation with Argatroban and Heparins Reduces Granulocyte Migration: Possible Impact on ECLS-Therapy?

Cardiovasc Ther 2020 25;2020:9783630. Epub 2020 Apr 25.

Department of Anesthesiology, University Medical Center Regensburg, Regensburg, Germany.

Introduction: Anticoagulants such as argatroban and heparins (low-molecular-weight and unfractionated) play an immense role in preventing thromboembolic complications in clinical practice. Nevertheless, they can also have a negative effect on the immune system. This study is aimed at investigating the influence of these substances on polymorphonuclear neutrophils (PMNs), whose nonspecific defense mechanisms can promote thrombogenesis. Read More

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http://dx.doi.org/10.1155/2020/9783630DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7196999PMC

Association of -Blocker Therapy at Discharge with Clinical Outcomes after Acute Coronary Syndrome in Patients without Heart Failure.

Cardiovasc Ther 2020 24;2020:4351469. Epub 2020 Apr 24.

Department of Cardiology, The State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Aim: To evaluate the clinical impact of -blocker in patients with adequate left ventricular ejection function (LVEF) who underwent percutaneous coronary intervention (PCI) for acute coronary syndrome (ACS).

Methods: A total of 10,724 consecutive patients who underwent PCI throughout 2013 were prospectively enrolled in the study. Among these, we analyzed 5,631 ACS patients who were discharged with LVEF ≥ 40%. Read More

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http://dx.doi.org/10.1155/2020/4351469DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7196986PMC
April 2020
2.362 Impact Factor

Efficacy and Safety of Non-Vitamin K Anticoagulants for Atrial Fibrillation in Relation to Different Renal Function Levels: A Network Meta-Analysis.

Cardiovasc Ther 2020 22;2020:2683740. Epub 2020 Apr 22.

Department of Cardiology, Affiliated ZhongDa Hospital of Southeast University (HZ), Nanjing 210009, China.

Background: We performed a network meta-analysis (NMA) comparing the efficacy (stroke or systemic embolism) and safety (major bleeding) among different non-vitamin K antagonist oral anticoagulants (NOACs) in patients with atrial fibrillation (AF) and renal impairment, with the aim of recommending the proper drug and the dose based on renal function.

Methods: We searched PubMed, EMBASE, Web of Science, and Cochrane Library with the items "dabigatran, edoxaban, apixaban, rivaroxaban, warfarin, and atrial fibrillation" through August 2019. NMA was analyzed with R (version 3. Read More

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http://dx.doi.org/10.1155/2020/2683740DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7197012PMC

The Relation between Volume and Outcome of Transcatheter and Surgical Aortic Valve Replacement: A Systematic Review and Meta-Analysis.

Cardiovasc Ther 2020 18;2020:2601340. Epub 2020 Apr 18.

Department of Cardiology, The Third People's Hospital of Chengdu, The Affiliated Hospital of Southwest Jiaotong University, China.

Transcatheter aortic valve replacement (TAVR) and surgical aortic valve replacement (SAVR) are standard procedures for dealing with severe aortic stenosis patients. Researchers have not carried out a systematic review of the volume-outcome relationship in TAVR and SAVR. Our study is intended to address this problem. Read More

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http://dx.doi.org/10.1155/2020/2601340DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7189304PMC

Dual Antiplatelet Therapy Duration in Acute Coronary Syndrome Patients: The State of the Art and Open Issues.

Cardiovasc Ther 2020 7;2020:6495036. Epub 2020 Apr 7.

Division of Cardiology, Azienda Ospedaliera-Universitaria "Maggiore della Carità", Eastern Piedmont University, Novara, Italy.

Conflicting results have been reported so far in pooled analyses and studies evaluating the optimum duration of dual antiplatelet therapy (DAPT) in acute coronary syndrome (ACS) patients. However, randomized clinical trials dedicated to this specific setting of higher thrombotic risk patients have only recently been completed, pointing at the noninferiority of a shorter strategy as compared to the traditional 12-month DAPT, furthermore allowing to reduce the risk of major bleeding complications. Therefore, a reconsideration of current clinical practice and guidelines should be certainly be advocated in light of the most recent updates, especially among ACS patients treated with percutaneous coronary intervention (PCI) and modern drug-eluting stents (DES). Read More

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http://dx.doi.org/10.1155/2020/6495036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7166288PMC

Isoliquiritigenin Inhibits Atherosclerosis by Blocking TRPC5 Channel Expression.

Cardiovasc Ther 2020 7;2020:1926249. Epub 2020 Apr 7.

Department of Pathophysiology, Binzhou Medical University, 346# Guanhai Road, Yantai, Shandong 264003, China.

Isoliquiritigenin (ISL) is a flavonoid isolated mainly from the licorice plant, a traditional Chinese herb. ISL has shown anticancer, anti-inflammatory, antioxidant, and antidiabetic activities. However, the pharmaceutical effects of ISL on atherosclerosis are seldom explored. Read More

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http://dx.doi.org/10.1155/2020/1926249DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7166290PMC

Extracorporeal Hemadsorption Glucocorticoids during Cardiopulmonary Bypass: A Prospective, Randomized, Controlled Trial.

Cardiovasc Ther 2020 27;2020:7834173. Epub 2020 Mar 27.

Clinical Department of Anaesthesiology and Perioperative Intensive Therapy, University Medical Centre Ljubljana, Ljubljana, Slovenia.

Extracorporeal hemadsorption may reduce inflammatory reaction in cardiopulmonary bypass (CPB) surgery. Glucocorticoids have been used during open-heart surgery for alleviation of systemic inflammation after CPB. We compared intraoperative hemadsorption and methylprednisolone, with usual care, during complex cardiac surgery on CPB, for inflammatory responses, hemodynamics, and perioperative course. Read More

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http://dx.doi.org/10.1155/2020/7834173DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7149340PMC

The Role of Clopidogrel in 2020: A Reappraisal.

Cardiovasc Ther 2020 16;2020:8703627. Epub 2020 Mar 16.

Dipartimento Cardio Neuro Vascolare, Ospedale, San Donato, Arezzo, Italy.

Antiplatelet therapy is the mainstay of treatment and secondary prevention of cardiovascular disease (CVD), including acute coronary syndrome (ACS), transient ischemic attack (TIA) or minor stroke, and peripheral artery disease (PAD). The P2Y inhibitors, of which clopidogrel was the first, play an integral role in antiplatelet therapy and therefore in the treatment and secondary prevention of CVD. This review discusses the available evidence concerning antiplatelet therapy in patients with CVD, with a focus on the role of clopidogrel. Read More

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http://dx.doi.org/10.1155/2020/8703627DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7140149PMC

Association between P2RY12 Gene Polymorphisms and IVIG Resistance in Kawasaki Patients.

Cardiovasc Ther 2020 10;2020:3568608. Epub 2020 Mar 10.

Department of Clinical Lab, Guangzhou Institute of Pediatrics, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, Guangdong, China.

Children with Kawasaki disease (KD) resistant to intravenous immunoglobulin (IVIG) have a higher incidence of coronary artery lesions (CAL). Despite the association between Purinergic receptor P2Y12 (P2RY12) polymorphism, KD genetic susceptibility, and CAL complications being proved, few studies have assessed the relationship between P2RY12 polymorphisms and IVIG resistance in patients with KD. We recruited 148 KD patients with IVIG resistance and 611 with IVIG sensitivity and selected five P2RY12 polymorphisms: rs9859538, rs1491974, rs7637803, rs6809699, and rs2046934. Read More

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http://dx.doi.org/10.1155/2020/3568608DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7085825PMC
March 2020
2.362 Impact Factor

Discharge Hemoglobin Association with Long-Term Outcomes of ST-Elevation Myocardial Infarction Patients Undergoing Primary Percutaneous Coronary Intervention.

Cardiovasc Ther 2020 27;2020:8647837. Epub 2020 Feb 27.

Cardiovascular Center, The First Hospital of Jilin University, Changchun 130021, China.

Background: Anemia following acute myocardial infarction (AMI) is associated with poor outcomes. While previous studies in patients with AMI have focused on anemia at admission, we hypothesized that hemoglobin (Hb) decline during hospitalization and lower discharge Hb would be associated with greater long-term mortality in patients undergoing primary percutaneous coronary intervention (PCI) for ST-segment elevation myocardial infarction (STEMI).

Methods: We analyzed records of 983 STEMI patients who were treated with primary PCI. Read More

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http://dx.doi.org/10.1155/2020/8647837DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7068153PMC

Effects of Angiotensin-Converting Enzyme Inhibitors on Arterial Stiffness: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Cardiovasc Ther 2020 25;2020:7056184. Epub 2020 Feb 25.

Department of Cardiology, Lanzhou University Second Hospital, Lanzhou, China.

To determine the effects of ACEIs on arterial stiffness, a meta-analysis of randomized controlled trials was conducted. Relevant articles that investigated the effects of ACEIs on arterial stiffness from PubMed, Embase, and the Cochrane library from inception to September 2018 were systematically retrieved. The investigated outcomes included brachial-ankle pulse wave velocity (ba-PWV) and carotid-femoral PWV (cf-PWV) by using weighted mean differences (WMDs) and 95% confidence intervals (CIs) with the random-effects model. Read More

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http://dx.doi.org/10.1155/2020/7056184DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7068147PMC
June 2020
2.362 Impact Factor

Hyperuricemia is a Risk Factor for One-Year Overall Survival in Elderly Female Patients with Acute Coronary Syndrome.

Cardiovasc Ther 2020 22;2020:2615147. Epub 2020 Feb 22.

Department of Cardiology, The Second Xiangya Hospital of Central South University, Changsha, China.

Background: Hyperuricemia is a risk factor for cardiovascular diseases, but the impact of hyperuricemia and sex-related disparities is not fully clear in elderly patients with acute coronary syndrome (ACS).

Objective: To investigate the association between hyperuricemia and 1-year all-cause mortality in elderly patients with ACS.

Methods: This retrospective cohort study included 711 consecutive ACS patients aged ≥75 years, hospitalized in our center between January 2013 and December 2017. Read More

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http://dx.doi.org/10.1155/2020/2615147DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7057023PMC

Bredemolic Acid Improves Cardiovascular Function and Attenuates Endothelial Dysfunction in Diet-Induced Prediabetes: Effects on Selected Markers.

Cardiovasc Ther 2020 11;2020:1936406. Epub 2020 Feb 11.

Department of Physiology, School of Laboratory Medicine and Medical Sciences, College of Health Sciences, University of KwaZulu-Natal, Westville, Durban, South Africa.

Prediabetes is an intermediate hyperglycaemic state which has been associated with cardiovascular dysfunction. However, cardiovascular dysfunction is not only caused by intermediate hyperglycaemia but also endothelial dysfunction, inflammation, and oxidative stress associated with prediabetes. Bredemolic acid (BA), an isomer of maslinic acid, has been reported to ameliorate the intermediate hyperglycaemia found in prediabetes; however, the effects of this triterpene on cardiovascular function have not yet been determined. Read More

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http://dx.doi.org/10.1155/2020/1936406DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7036119PMC

A Nomogram Based on Apelin-12 for the Prediction of Major Adverse Cardiovascular Events after Percutaneous Coronary Intervention among Patients with ST-Segment Elevation Myocardial Infarction.

Cardiovasc Ther 2020 6;2020:9416803. Epub 2020 Feb 6.

Department of Structural Heart Disease, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, China.

Objective: This study aimed to establish a clinical prognostic nomogram for predicting major adverse cardiovascular events (MACEs) after primary percutaneous coronary intervention (PCI) among patients with ST-segment elevation myocardial infarction (STEMI).

Methods: Information on 464 patients with STEMI who performed PCI procedures was included. After removing patients with incomplete clinical information, a total of 460 patients followed for 2. Read More

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http://dx.doi.org/10.1155/2020/9416803DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7026703PMC

Burden of Coronary Artery Disease and Peripheral Artery Disease: A Literature Review.

Cardiovasc Ther 2019 26;2019:8295054. Epub 2019 Nov 26.

Bayer AG, Berlin, Germany.

Background: Atherothrombotic disease, including coronary artery disease (CAD) and peripheral artery disease (PAD), can lead to cardiovascular (CV) events, such as myocardial infarction, stroke, limb ischemia, heart failure, and CV death.

Aim: Evaluate the humanistic and economic burden of CAD and PAD and identify unmet needs through a comprehensive literature review.

Methods: Relevant search terms were applied across online publication databases. Read More

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http://dx.doi.org/10.1155/2019/8295054DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7024142PMC

Pharmacokinetic Interactions between Cardiovascular Medicines and Plant Products.

Cardiovasc Ther 2019 2;2019:9402781. Epub 2019 Sep 2.

Faculty of Pharmacy, Grigore T.Popa University of Medicine and Pharmacy Iasi, 700115 Iasi, Romania.

The growing use of plant products among patients with cardiovascular pharmacotherapy raises the concerns about their potential interactions with conventional cardiovascular medicines. Plant products can influence pharmacokinetics or/and pharmacological activity of coadministered drugs and some of these interactions may lead to unexpected clinical outcomes. Numerous studies and case reports showed various pharmacokinetic interactions that are characterized by a high degree of unpredictability. Read More

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http://dx.doi.org/10.1155/2019/9402781DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7012273PMC

The Functional Severity Assessment of Coronary Stenosis Using Coronary Computed Tomography Angiography-Based Myocardial Mass at Risk and Minimal Lumen Diameter.

Cardiovasc Ther 2020 30;2020:6716130. Epub 2020 Jan 30.

Division of Cardiovascular Medicine, Department of Internal Medicine, Kurume University School of Medicine, Kurume, Japan.

Background: We investigated whether or not the addition of myocardial mass at risk (MMAR) to quantitative coronary angiography was useful for diagnosing functionally significant coronary stenosis in the daily practice.

Methods: We retrospectively enrolled 111 consecutive patients with 149 lesions who underwent clinically indicated coronary computed tomography angiography and subsequent elective coronary angiography with fractional flow reserve (FFR) measurement. MMAR was calculated using a workstation-based software program with ordinary thin slice images acquired for the computed tomography, and the minimal lumen diameter (MLD) and the diameter stenosis were measured with quantitative coronary angiography. Read More

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http://dx.doi.org/10.1155/2020/6716130DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7013296PMC

Av3 Single-Stranded DNA Aptamer Attenuates Vascular Smooth Muscle Cell Proliferation and Migration via Ras-PI3K/MAPK Pathway.

Cardiovasc Ther 2020 21;2020:6869856. Epub 2020 Jan 21.

Department of Cardiovascular Surgery, Renmin Hospital of Wuhan University, Wuhan, China.

Objectives: To observe the effect of av3 single-stranded (ss) DNA on proliferation and migration of vascular smooth muscle cells (VSMCs) and its potential mechanism.

Background: Percutaneous transluminal coronary angioplasty (PTCA) is currently the preferred method for the treatment of coronary heart disease. However, vascular restenosis still occurs after PTCA treatment, severely affecting the clinical efficacy of PTCA. Read More

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http://dx.doi.org/10.1155/2020/6869856DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6995496PMC

Exploring Current Evidence on the Past, the Present, and the Future of the Heart Team: A Narrative Review.

Cardiovasc Ther 2020 4;2020:9241081. Epub 2020 Jan 4.

"Grigore T. Popa" University of Medicine and Pharmacy, Iasi, Romania.

Introduction: Including healthcare professionals dealing with cardiovascular diseases, Heart Team is a concept/structure designed for selecting diagnostic strategies, facilitating therapeutic decisions, and improving cardiovascular outcomes in patients with complex heart pathologies, requiring input from different subspecialties and the necessity of a multidisciplinary approach. The aim of this narrative review is to search for and to summarize current evidence regarding Heart Team and to underline the future directions for the development of this concept.

Methods: We searched the electronic database of PubMed, SCOPUS, and Cochrane CENTRAL for studies including Heart Team. Read More

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http://dx.doi.org/10.1155/2020/9241081DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6964708PMC

Predictive Value of Electromechanical Activation Time for In-Hospital Major Cardiac Adverse Events in Heart Failure Patients.

Cardiovasc Ther 2020 2;2020:4532596. Epub 2020 Jan 2.

Division of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China.

Objective: This prospective study aimed to evaluate the value of the cardiac cycle time-corrected electromechanical activation time (EMATc) measured at admission for predicting major cardiac adverse events (MACEs) in hospitalized patients with chronic heart failure (CHF).

Methods: CHF patients with a left ventricular ejection fraction (LVEF) lower than 50% ( = 145) were enrolled in this study. Documented clinical end-points (MACEs) included cardiogenic death, onset of acute HF as assessed with invasive and noninvasive mechanical ventilation, and cardiogenic shock. Read More

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http://dx.doi.org/10.1155/2020/4532596DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6961597PMC

Lipid Lowering Treatment and Eligibility for PCSK9 Inhibition in Post-Myocardial Infarction Patients in Italy: Insights from Two Contemporary Nationwide Registries.

Cardiovasc Ther 2020 3;2020:3856242. Epub 2020 Jan 3.

Division of Cardiology, S. Giovanni Evangelista Hospital, Tivoli (Roma), Italy.

Introduction: The current use of lipid lowering therapies and the eligibility for proprotein convertase subtilisin/kexin-9 (PCSK9) inhibitors of patients surviving a myocardial infarction (MI) is poorly known.

Methods: Using the data from two contemporary, nationwide, prospective, real-world registries of patients with stable coronary artery disease, we sought to describe the lipid lowering therapies prescribed by cardiologists in patients with a prior MI and the resulting eligibility for PCSK9 inhibitors according to the European Society of Cardiology (ESC)/European Atherosclerosis Society (EAS) and the Italian regulatory agency (Agenzia Italiana del Farmaco; AIFA) criteria. The study cohort was stratified according to the following low-density lipoprotein cholesterol (LDL-C) levels at the time of enrolment: <70 mg/dl; 70-99 mg/dl and ≥100 mg/dl. Read More

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http://dx.doi.org/10.1155/2020/3856242DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6961602PMC

Long-Term Prognosis of Suspected Myocarditis and Cardiomyopathy Associated with Viral Infection of the Myocardial Tissue: A Meta-Analysis of Cohort Studies.

Cardiovasc Ther 2019 16;2019:9342792. Epub 2019 Dec 16.

Cardiovascular Center, The Eighth Affiliated Hospital, Sun Yat-Sen University, Shenzhen, China.

Aim: Myocarditis and cardiomyopathy impose a substantial economic burden on society. Many studies have examined the effects of various predictors on the prognosis of these diseases, such as the left ventricular systolic function, the New York Heart Association glomerular filtration rate, the QT interval, and the presence of viruses. In the present study, we conducted a meta-analysis of cohort studies to investigate the significance of the presence of viruses in the myocardial tissue on the prognosis of these diseases. Read More

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http://dx.doi.org/10.1155/2019/9342792DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6942786PMC
February 2020

Effect of Repeated Remote Ischemic Preconditioning on Peripheral Arterial Disease in Patients Suffering from Intermittent Claudication.

Cardiovasc Ther 2019 10;2019:9592378. Epub 2019 Dec 10.

Department of Cardiology, Firat University, School of Medicine Hospital, Elazığ, Turkey.

Background/objective: Intermittent claudication (IC) is the symptom of peripheral artery disease (PAD) and causes functional disability. Remote ischemic preconditioning (RIPC), is a phenomenon in which a short period of sub-critical ischemia, protects tissues against ischemia/reperfusion/injury. We considered to test the hypothesis that RIPC in PAD patients suffering from IC would increase muscle resistance to ischemia and thus improve walking-capacity. Read More

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http://dx.doi.org/10.1155/2019/9592378DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6925938PMC
February 2020

Roles of Achieved Levels of Low-Density Lipoprotein Cholesterol and High-Sensitivity C-Reactive Protein on Cardiovascular Outcome in Statin Therapy.

Cardiovasc Ther 2019 21;2019:3824823. Epub 2019 Nov 21.

Division of Cardiology, Department of Internal Medicine, Korea University Guro Hospital, Seoul 152-703, Republic of Korea.

In statin therapy, the prognostic role of achieved low-density lipoprotein cholesterol (LDL-C) and high-sensitivity C-reactive protein (hsCRP) in cardiovascular outcomes has not been fully elucidated. A total of 4,803 percutaneous coronary intervention (PCI)-naïve patients who prescribed moderate intensity of statin therapy were followed up. Total and each component of major adverse cardiovascular events (MACE) according to LDL-C and hsCRP quartiles were compared. Read More

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http://dx.doi.org/10.1155/2019/3824823DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6906885PMC
February 2020

Benefits and Risks of Clopidogrel vs. Aspirin Monotherapy after Recent Ischemic Stroke: A Systematic Review and Meta-Analysis.

Cardiovasc Ther 2019 1;2019:1607181. Epub 2019 Dec 1.

Sanofi, General Medicines and Emerging Markets, Singapore.

Aim: Though combination of clopidogrel added to aspirin has been compared to aspirin alone in patients with stroke or transient ischemic attack, limited data exists on the relative efficacy and safety between clopidogrel and aspirin monotherapy in patients with a recent ischemic stroke. We aimed to compare clopidogrel versus aspirin monotherapy in this population.

Methods: PubMed, Embase, and CENTRAL databases were searched from inception to May 2018 to identify clinical trials and observational studies comparing clopidogrel versus aspirin for secondary prevention in patients with recent ischemic stroke within 12 months. Read More

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http://dx.doi.org/10.1155/2019/1607181DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6913341PMC
February 2020

Role and Effective Therapeutic Target of Gut Microbiota in Heart Failure.

Cardiovasc Ther 2019 16;2019:5164298. Epub 2019 Nov 16.

First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, 314 An Shan Xi Road, Nan Kai District, Tianjin 300193, China.

Although the mechanism of the occurrence and development of heart failure has been continuously explored in the past ten years, the mortality and readmission rate of heart failure is still very high. Modern studies have shown that gut microbiota is associated with a variety of cardiovascular diseases, among which the study of gut microbiota and heart failure attracts particular attention. Therefore, understanding the role of gut microbiota in the occurrence and development of heart failure will help us further understand the pathogenesis of heart failure and provide new ideas for its treatment. Read More

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http://dx.doi.org/10.1155/2019/5164298DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6885196PMC
February 2020

Association of GDF-15 and Syntax Score in Patient with Acute Myocardial Infarction.

Cardiovasc Ther 2019 5;2019:9820210. Epub 2019 Mar 5.

Department of Cardiothoracic Surgery, Nanchong Central Hospital, The Second Clinical College of North Sichuan Medical College, Nanchong, Sichuan 637900, China.

Aims: GDF-15 is considered to be an important biomarker for cardiovascular events, but the differences in serum GDF-15 levels between acute myocardial infarction (AMI) patients and non-AMI patients warrant further investigation.

Methods: A cohort of 409 subjects was enrolled in the current study. The Syntax score was calculated from the baseline coronary angiography results by using online methods. Read More

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http://dx.doi.org/10.1155/2019/9820210DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6739804PMC

Outcomes of Cardiac Contractility Modulation: A Systematic Review and Meta-Analysis of Randomized Clinical Trials.

Cardiovasc Ther 2019 17;2019:9769724. Epub 2019 Jun 17.

Department of Cardiovascular Medicine, Henry Ford Hospital, Detroit, MI, USA.

Background: Cardiac contractility modulation (CCM) is a device therapy for systolic heart failure (HF) in patients with narrow QRS. We aimed to perform an updated meta-analysis of the randomized clinical trials (RCTs) to assess the efficacy and safety of CCM therapy.

Methods: We conducted a systematic review and meta-analysis of randomized clinical trials (RCTs) between January 2001 and June 2018. Read More

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http://dx.doi.org/10.1155/2019/9769724DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6739758PMC
March 2020
2.362 Impact Factor

Sex-Specific Cut-Offs for High-Sensitivity Cardiac Troponin: Is Less More?

Cardiovasc Ther 2019 5;2019:9546931. Epub 2019 Feb 5.

Department of Experimental Medicine, Sapienza-University of Rome, Rome, Italy.

Management of patients presenting to the Emergency Department with chest pain is continuously evolving. In the setting of acute coronary syndrome, the availability of high-sensitivity cardiac troponin assays (hs-cTn) has allowed for the development of algorithms aimed at rapidly assessing the risk of an ongoing myocardial infarction. However, concerns were raised about the massive application of such a simplified approach to heterogeneous real-world populations. Read More

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http://dx.doi.org/10.1155/2019/9546931DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6739766PMC

Combating Donor Organ Shortage: Organ Care System Prolonging Organ Storage Time and Improving the Outcome of Heart Transplantations.

Cardiovasc Ther 2019 1;2019:9482797. Epub 2019 Apr 1.

Faculty of Medicine, Tarumanagara University, Jl. Letjen S. Parman No. 1, West Jakarta, Indonesia.

Introduction: Cardiovascular diseases are the number one cause of death globally contributing to 37% of all global deaths. A common complication of cardiovascular disease is heart failure, where, in such cases, the only solution would be to conduct a heart transplant. Every 10 minutes a new patient is added to the transplant waiting list. Read More

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http://dx.doi.org/10.1155/2019/9482797DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6739795PMC

New Insights into the Association between Fibrinogen and Coronary Atherosclerotic Plaque Vulnerability: An Intravascular Optical Coherence Tomography Study.

Cardiovasc Ther 2019 2;2019:8563717. Epub 2019 Apr 2.

Department of Coronary Heart Disease, the First Affiliated Hospital of Xinjiang Medical University, Urumqi 830011, China.

Background: Fibrinogen levels have been associated with coronary plaque vulnerability in experimental studies. However, it has yet to be determined if serum fibrinogen levels are independently associated with coronary plaque vulnerability as detected by optical coherence tomography (OCT) in patients with coronary heart disease.

Methods: Patients with coronary heart disease (CHD) who underwent coronary angiography and OCT in our department from January 2015 to August 2018 were included in this study. Read More

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http://dx.doi.org/10.1155/2019/8563717DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6740041PMC

Cuban Sugar Cane Wax Acid and Policosanol Showed Similar Atheroprotective Effects with Inhibition of LDL Oxidation and Cholesteryl Ester Transfer via Enhancement of High-Density Lipoproteins Functionality.

Cardiovasc Ther 2019 24;2019:8496409. Epub 2019 Feb 24.

Department of Biochemistry and Molecular Biology, Smart-Aging Convergence Research Center, College of Medicine, Yeungnam University, Daegu 705-717, Republic of Korea.

Background: Cuban sugarcane wax acids (SCWA) and policosanol (PCO) are mixtures of higher aliphatic acids and alcohols, respectively, purified from sugarcane wax with different chief components. Although it has been known that they have antioxidant and anti-inflammatory activities, physiological properties on molecular mechanism of SCWA have been less studied than PCO.

Methods: In this study, we compared antiatherogenic activities of SCWA and PCO via encapsulation with reconstituted high-density lipoproteins (rHDL). Read More

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http://dx.doi.org/10.1155/2019/8496409DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6739770PMC

Identification of Differentially Expressed Genes and Signaling Pathways in Acute Myocardial Infarction Based on Integrated Bioinformatics Analysis.

Cardiovasc Ther 2019 1;2019:8490707. Epub 2019 Aug 1.

Department of Cardiology, Affiliated Nanping First Hospital, Fujian Medical University, Nanping 353000, Fujian Province, China.

Background: Acute myocardial infarction (AMI) is a common disease with high morbidity and mortality around the world. The aim of this research was to determine the differentially expressed genes (DEGs), which may serve as potential therapeutic targets or new biomarkers in AMI.

Methods: From the Gene Expression Omnibus (GEO) database, three gene expression profiles (GSE775, GSE19322, and GSE97494) were downloaded. Read More

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http://dx.doi.org/10.1155/2019/8490707DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6739802PMC

Meta-Analysis of Atrial Fibrillation Ablation in Patients with Systolic Heart Failure.

Cardiovasc Ther 2019 6;2019:8181657. Epub 2019 Jan 6.

Michigan State University, McLaren Greater Lansing, MI, USA.

Atrial fibrillation (AF) and heart failure (HF) are two common conditions that often coexist and predispose each to one another. AF increases hospitalization rates and overall mortality in patients with HF. The current available therapeutic options for AF in patients with HF are diverse and guidelines do not provide a clear consensus regarding the best management approach. Read More

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http://dx.doi.org/10.1155/2019/8181657DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6739791PMC

Comparison of the Effect of Fimasartan versus Valsartan on Blood Pressure Variability in Acute Ischemic Stroke: A Double-Blind Randomized Trial.

Cardiovasc Ther 2019 2;2019:7836527. Epub 2019 Jun 2.

Department of Neurology, Gil Medical Center, Gachon University College of Medicine, Incheon, Republic of Korea.

Higher blood pressure variability (BPV) is associated with poor functional outcome and mortality in acute stroke. This randomized controlled trial was conducted to compare the effect on BPV between fimasartan and valsartan (Boryung Pharmaceutical Co., Ltd. Read More

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http://dx.doi.org/10.1155/2019/7836527DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6739756PMC

Stroke Risk Status, Anticoagulation Treatment, and Quality-of-Life in Chinese Patients with Atrial Fibrillation: China Registry of Atrial Fibrillation (CRAF).

Cardiovasc Ther 2019 21;2019:7372129. Epub 2019 Mar 21.

Department of Cardiology, Peking University People's Hospital, Beijing, 100044, China.

To investigate the contemporary status of stroke risk profile, antithrombotic treatment, and quality-of-life (QoL) of patients with all types of atrial fibrillation (AF) in China. This is a multicenter, cross-sectional study. Tertiary (80%) and Tier 2 hospitals (20%) were identified in different economic regions (Northeast, East, West, and Middle) by using a simple random sampling. Read More

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http://dx.doi.org/10.1155/2019/7372129DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6739760PMC