1,665 results match your criteria Cardiovascular Pathology[Journal]


Sudden death by massive systemic embolism from cardiac myxoma. Role of the clinical autopsy and review of literature.

Cardiovasc Pathol 2020 May 23;49:107244. Epub 2020 May 23.

Area of Pathology, Department of Woman and Child Health and Public Health, Fondazione Policlinico Universitario A. Gemelli IRCCS, Istituto di Anatomia Patologica, Università Cattolica Del Sacro Cuore, Rome, Italy.

Cardiac myxoma is a rare benign neoplasm of the heart. Historically myxomas were incidental findings during autopsies, however improved imaging techniques made these diagnosis possible in living patients, making the surgical treatment of these neoplasms achievable. Cardiac myxomas may occur both sporadically and in a familial context, often in the clinico-pathological picture of the Carney complex. Read More

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http://dx.doi.org/10.1016/j.carpath.2020.107244DOI Listing

Cardiovascular factors predicting poor outcome in COVID-19 patients.

Cardiovasc Pathol 2020 May 28;49:107246. Epub 2020 May 28.

Department of Internal Medicine, Saint Vincent Hospital, Worcester, MA, United States.

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http://dx.doi.org/10.1016/j.carpath.2020.107246DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7263269PMC

Cardiac tumors: three decades of experience from a tertiary center: are we changing diagnostic work-up with new imaging tools?

Cardiovasc Pathol 2020 May 18;49:107242. Epub 2020 May 18.

Cardiothoracic Surgery Department, Hospital de Santa Cruz - Centro Hospitalar de LisboaOcidental, Carnaxide, Portugal.

Background: Primary cardiac tumours are relatively rare. Cardiac myxomas are the most prevalent and in a significant proportion of cases they are accidentally discovered in asymptomatic patients. Noninvasive definitive diagnosis remains challenging despite improvements provided by newer imaging tools. Read More

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http://dx.doi.org/10.1016/j.carpath.2020.107242DOI Listing

Prevention of heart failure with preserved ejection fraction (HFpEF): reexamining microRNA-21 inhibition in the era of oligonucleotide-based therapeutics.

Cardiovasc Pathol 2020 May 19;49:107243. Epub 2020 May 19.

The University of Texas Health Science Center at Houston, McGovern Medical School.

Heart failure with preserved ejection fraction (HFpEF) accounts for 50% of cases of heart failure, which is the most common cause of hospitalization in US patients over the age of 65. HFpEF pathogenesis is increasingly believed to be due to pathological hypertrophy and fibrosis of the myocardium that may be a result of systemic inflammation from comorbid conditions such as hypertension, diabetes mellitus, chronic obstructive pulmonary disease, anemia, chronic kidney disease and others. It is believed that oxidative stress triggers a process of pathological hypertrophy and fibrosis in cardiac endothelial cells, which leads to increased left ventricle filling pressures and, eventually, symptoms of heart failure. Read More

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http://dx.doi.org/10.1016/j.carpath.2020.107243DOI Listing

The effect of olmesartan on aortic intimal thickening after balloon injury through Apelin/APJ.

Cardiovasc Pathol 2020 May 13;49:107230. Epub 2020 May 13.

Department of Cardiology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong Province 266003,China.

Purpose: Restenosis is the main complication after percutaneous coronary intervention. The proliferation of new intima contributes to the process. In this study, we aimed to explore the effect of olmesartan on intimal thickening after balloon injury and possible mechanism. Read More

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http://dx.doi.org/10.1016/j.carpath.2020.107230DOI Listing

Hypertrophic cardiomyopathy masquerading as sarcoidosis: cases illustrating cardiac imaging overlap relative to pathology.

Cardiovasc Pathol 2020 May 19;49:107234. Epub 2020 May 19.

Centre for Heart Lung Innovation, St Paul's Hospital/University of British Columbia, Vancouver, BC, Canada; Departments of Pathology and Laboratory Medicine, Providence Health Care/University of British Columbia, Vancouver, BC, Canada.

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http://dx.doi.org/10.1016/j.carpath.2020.107234DOI Listing

The comeback of syphilitic aortitis.

Cardiovasc Pathol 2020 May 13;49:107229. Epub 2020 May 13.

Division of Histopathology, University Hospital, Pisa, Italy.

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http://dx.doi.org/10.1016/j.carpath.2020.107229DOI Listing

A case of surgically resected cardiac rhabdomyoma with progressive left ventricular outflow tract obstruction.

Cardiovasc Pathol 2020 May 12;49:107226. Epub 2020 May 12.

Department of Pathology, Universiti Kebangsaan Malaysia Medical Centre, 56000 Kuala Lumpur, Malaysia. Electronic address:

Cardiac rhabdomyoma is the most prevalent cardiac tumors in the pediatric population, in close association with tuberous sclerosis complex. It is usually detected antenatally or postnatally by echocardiography. Clinical presentations depend greatly on the size and position of the tumor mass. Read More

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http://dx.doi.org/10.1016/j.carpath.2020.107226DOI Listing

Accelerated miniature swine models of advanced atherosclerosis: A review based on morphology.

Cardiovasc Pathol 2020 May 16;49:107241. Epub 2020 May 16.

Cardiovascular Insititute, Dongzhimen Hospital of Beijing University of Chinese Medicine, Beijing, China. Electronic address:

In order to accelerate development of atherosclerosis(AS) in miniature swine models, varieties of strategies and methods have been explored. In addition to traditional methods such as high cholesterol feeding and balloon injury, new methods such as familial hypercholesterolemia induced by gene editing and intramural injection have been applied in recent years. Although it has been claimed that these methods have successfully aggravated lesion areas and stenosis, lesion features induced by different strategies have shown heterogeneity in morphology. Read More

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http://dx.doi.org/10.1016/j.carpath.2020.107241DOI Listing

Morphometric characterization of collagen and fat in normal ventricular myocardium.

Cardiovasc Pathol 2020 Sep - Oct;48:107224. Epub 2020 May 1.

Cardiology Clinical Academic Group, Molecular and Clinical Sciences Institute, St George's, University of London, London, United Kingdom. Electronic address:

Objective: We used automated image analysis software to determine the proportion of collagen, fat, and myocytes across six histological regions of normal ventricular myocardium.

Methods: Twenty-nine non-cardiac death cases referred to our national cardiac pathology center were included in this study. Whole hearts were macroscopically and microscopically normal following expert histopathological evaluation. Read More

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http://dx.doi.org/10.1016/j.carpath.2020.107224DOI Listing

Cardiovascular ochronosis.

Cardiovasc Pathol 2020 Sep - Oct;48:107219. Epub 2020 Mar 7.

Baylor Scott & White Heart and Vascular Institute, Baylor University Medical Center, Baylor Scott & White Health, Dallas, Texas, USA; Department of Pathology, Baylor University Medical Center, Baylor Scott & White Health, Dallas, Texas, USA; Department of Internal Medicine (Division of Cardiology), Baylor University Medical Center, Baylor Scott & White Health, Dallas, Texas, USA. Electronic address:

In this review, we summarize previously reported case reports (n=66) in which the presence of ochronotic pigment was found in one or more cardiovascular structures either at necropsy or after operative excision of a cardiac valve or portions of arteries or both. As illustration, we describe black pigment in operatively excised aortic valves and aorta in 2 patients, both probably examples of secondary ochronosis. Ochronosis appears to have fascinated a number of prominent historical figures in medicine, and this review also summarizes their important contributions to this topic. Read More

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http://dx.doi.org/10.1016/j.carpath.2020.107219DOI Listing

Saprochaete capitata aortitis in an immunocomopetent patient after myocardial revascularization.

Cardiovasc Pathol 2020 Sep - Oct;48:107223. Epub 2020 Apr 28.

Cardiothoracic Department, University Hospital of Udine, Udine, Italy.

Saprochaete species infection is a rare fungal disease reported so far only in immunocompromised patients. We describe the first case of aortitis caused by Saprochaete capitata, presenting as ascending aorta aneurysm, with secondary endophthalmitis in an immunocompetent patient. Infection by Saprochaete capitata is potentially fatal, with a mortality ranging from 50% to 90% of cases. Read More

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http://dx.doi.org/10.1016/j.carpath.2020.107223DOI Listing

Recurrent takotsubo cardiomyopathy: Further insights into morphological patterns.

Cardiovasc Pathol 2020 Sep - Oct;48:107225. Epub 2020 Apr 26.

Trakya University, Pathology Department, Edirne, TURKEY.

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http://dx.doi.org/10.1016/j.carpath.2020.107225DOI Listing

STEMI during the COVID-19 Pandemic - An Evaluation of Incidence.

Cardiovasc Pathol 2020 Sep - Oct;48:107232. Epub 2020 May 1.

Section on Cardiovascular Medicine, Department of Internal Medicine, Wake Forest Baptist Health System, 1 Medical Center Blvd, Winston-Salem, North Carolina, 27103, United States.

The COVID-19 pandemic has dramatically changed the practice medicine on a global scale during the year 2020. With fewer patients presenting to hospitals with the diagnosis of STEMI, healthcare workers are wondering what is causing this decline. This piece presents data from two medical centers and addresses several possible causes to explain this phenomenon. Read More

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http://dx.doi.org/10.1016/j.carpath.2020.107232DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7194046PMC

Commentary from Dr. Robert Padera regarding thrombus on the inflow cannula of the heartware HVAD: An update.

Authors:
Robert Padera

Cardiovasc Pathol 2020 Sep - Oct;48:107220. Epub 2020 Mar 14.

Department of Pathology, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115. Electronic address:

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http://dx.doi.org/10.1016/j.carpath.2020.107220DOI Listing

The emerging spectrum of cardiopulmonary pathology of the coronavirus disease 2019 (COVID-19): Report of 3 autopsies from Houston, Texas, and review of autopsy findings from other United States cities.

Cardiovasc Pathol 2020 Sep - Oct;48:107233. Epub 2020 May 7.

Internal Medicine, McGovern Medical School, The University of Texas Health Science Center at Houston (UTHealth), Houston, Texas, USA; Center for Advanced Cardiopulmonary Therapies and Transplantation, McGovern Medical School and Memorial Hermann Hospital-Texas Medical Center, Houston, Texas, USA.

This paper collates the pathological findings from initial published autopsy reports on 23 patients with coronavirus disease 2019 (COVID-19) from 5 centers in the United States of America, including 3 cases from Houston, Texas. Findings confirm that COVID-19 is a systemic disease with major involvement of the lungs and heart. Acute COVID-19 pneumonia has features of a distinctive acute interstitial pneumonia with a diffuse alveolar damage component, coupled with microvascular involvement with intra- and extravascular fibrin deposition and intravascular trapping of neutrophils, and, frequently, with formation of microthombi in arterioles. Read More

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http://dx.doi.org/10.1016/j.carpath.2020.107233DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7204762PMC
July 2020
2.336 Impact Factor

Cardiac AA amyloidosis in a patient with obstructive hypertrophic cardiomyopathy.

Cardiovasc Pathol 2020 Sep - Oct;48:107218. Epub 2020 Mar 7.

Hypertrophic Cardiomyopathy Program, Leon H. Charney Division of Cardiology, New York University School of Medicine, New York, NY.

Cardiac amyloid A (AA) amyloidosis is rare. We present the case of a 72-year-old woman with obstructive hypertrophic cardiomyopathy (HCM) and biopsy-proven renal AA amyloidosis whose dyspnea and exercise intolerance had worsened over the previous year. Her AA amyloidosis was suspected to be secondary to chronic diverticulitis for which she had undergone hemicolectomy and sigmoidectomy 3 years prior. Read More

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http://dx.doi.org/10.1016/j.carpath.2020.107218DOI Listing

Obstructive sleep apnea and susceptibility to sudden cardiac death: A single player for both conditions?

Cardiovasc Pathol 2020 Jul - Aug;47:107222. Epub 2020 Apr 15.

Division of Pediatrics and Neonatology, Moscati Hospital, Aversa, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.carpath.2020.107222DOI Listing

Pathophysiological characteristics and therapeutic approaches for pulmonary injury and cardiovascular complications of coronavirus disease 2019.

Cardiovasc Pathol 2020 Jul - Aug;47:107228. Epub 2020 Apr 17.

Department of Internal Medicine, McGovern School of Medicine, University of Texas Health Science Center at Houston, Houston, TX, USA; Division of Pulmonary, Critical and Sleep Medicine, University of South California Keck School of Medicine, Los Angeles, CA, USA.

The pandemic of coronavirus disease 2019 (COVID-19) has emerged as a major health crisis, with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) having infected over a million people around the world within a few months of its identification as a human pathogen. Initially, SARS-CoV-2 infects cells in the respiratory system and causes inflammation and cell death. Subsequently, the virus spreads out and damages other vital organs and tissues, triggering a complicated spectrum of pathophysiological changes and symptoms, including cardiovascular complications. Read More

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http://dx.doi.org/10.1016/j.carpath.2020.107228DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7162778PMC

Pathology of unexpected sudden cardiac death: Obstructive sleep apnea is part of the challenge.

Cardiovasc Pathol 2020 Jul - Aug;47:107221. Epub 2020 Apr 18.

Department of Pathology and Laboratory Medicine, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX, USA.

Unexpected sudden cardiac death (SCD), sudden infant death syndrome (SIDS) and sudden intrauterine unexplained death (SIUD) are major unsolved, devastating forms of death that occur frequently. Obstructive sleep apnea (OSA) has been associated with increased cardiovascular and cerebrovascular morbidity and mortality, including sudden cardiac death (SCD). This editorial will review the pathology of SCD, including sudden infant death syndrome (SIDS) and sudden intrauterine unexplained death (SIUD); OSA with its cardiovascular consequences; the possible link between SCD and OSA, discussing the potential mechanisms underlying these two frequent, but yet overlooked pathologies. Read More

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http://dx.doi.org/10.1016/j.carpath.2020.107221DOI Listing
July 2020
2.336 Impact Factor

Lysosomal storage disorders affecting the heart: a review.

Cardiovasc Pathol 2020 Sep - Oct;48:107217. Epub 2020 Mar 4.

Department of Pathology and Laboratory Medicine, Ottawa Hospital and Faculty of Medicine, University of Ottawa, 451 Smyth Road, Ottawa, Ontario K1H 8M5, Canada.

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http://dx.doi.org/10.1016/j.carpath.2020.107217DOI Listing

Immunomodulatory treatment of immune checkpoint inhibitor-induced myocarditis: Pathway toward precision-based therapy.

Cardiovasc Pathol 2020 Jul - Aug;47:107211. Epub 2020 Feb 14.

Department of Cardiology, The University of Texas MD Anderson Cancer Center, 1400 Pressler Street, Unit 1451, Houston, TX 77030, United States.

Immune checkpoint inhibitor (ICI)-induced myocarditis carries a poor prognosis and is not fully understood. Similar to lymphocytic myocarditis and acute cellular rejection in heart transplant, ICI-induced myocarditis requires immune suppressive strategies. We aimed to describe ICI-induced myocarditis by presenting findings of comprehensive cardiovascular evaluations and outcomes of patients following a therapeutic approach similar to autoimmune disorders or allograft transplant rejection, and to discuss the molecular basis of the benefits of immune modulation and statins in ICI-myocarditis. Read More

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http://dx.doi.org/10.1016/j.carpath.2020.107211DOI Listing
July 2020
2.336 Impact Factor

Isomerism of the atrial appendages: morphology and terminology.

Cardiovasc Pathol 2020 Jul - Aug;47:107205. Epub 2020 Jan 16.

Department of Cardiac, Thoracic and Vascular Sciences and Public Health, University of Padua, Italy. Electronic address:

Background: Our aim is to identify the pathognomonic anatomical markers and the best terminology to describe the cardiac malformations associated with absent or multiple spleens, which are known as asplenia or polysplenia syndromes or isomerism.

Materials And Methods: We have reviewed 65 hearts with isomerism of atrial appendages of the Anatomical Collections of Congenital Heart Disease, Institute of Pathological Anatomy of the University of Padua consisting of 1800 specimens. All the hearts were classified according to sequential segmental classification. Read More

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http://dx.doi.org/10.1016/j.carpath.2020.107205DOI Listing
July 2020
2.336 Impact Factor

Mitochondria in aneurysms and dissections of the human ascending aorta.

Cardiovasc Pathol 2020 Jul - Aug;47:107207. Epub 2020 Jan 25.

Department of Biological Sciences, Federal University of São Paulo, Diadema, Brazil.

Factors causing the weakness that underlies thoracic aorta aneurysms and dissections are not well known. Based on the findings of apoptosis and ischemic-like necrosis, we hypothesized a possible role for mitochondrial disturbances in the pathogenesis of these diseases. To evaluate if mitochondria at the aortic medial layer are damaged, samples of ascending aortas with aneurysms (n = 6), acute dissections (n = 5), and hypertensive (n = 9) and normotensive controls (n = 7) were analyzed by transmission electron microscopy. Read More

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http://dx.doi.org/10.1016/j.carpath.2020.107207DOI Listing

Takotsubo Cardiomyopathy presenting with different morphological patterns in the same patient: a case report and review of the literature.

Cardiovasc Pathol 2020 Jul - Aug;47:107204. Epub 2020 Jan 15.

Michigan State University, East Lansing, MI, USA.

Background: Takotsubo Cardiomyopathy is characterized by transient left ventricular systolic dysfunction, which often mimics a myocardial infarction and is usually triggered by emotional or physical stress. There are four variants of Takotsubo Cardiomyopathy, based on the affected left ventricular area.

Case: We report a 75-year-old female with a past medical history of diabetes mellitus, hypertension, hyperlipidemia, and chronic kidney disease who presented with chest pain that had started after a stressful, emotional event. Read More

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http://dx.doi.org/10.1016/j.carpath.2020.107204DOI Listing

Multiple ulcerations and perforation in the small intestine after steroid treatment in eosinophilic granulomatosis with polyangiitis: a case report and literature review.

Cardiovasc Pathol 2020 Jul - Aug;47:107193. Epub 2019 Dec 18.

Department of Cellular and Organ Pathology, Graduate School of Medicine, Akita University, Akita, Japan.

Eosinophilic granulomatosis with polyangiitis (EGPA), formerly called Churg-Strauss syndrome, is an uncommon disease with pathological features consisting of systemic necrotizing vasculitis, eosinophilic infiltration, and granulomatous or nongranulomatous extravascular eosinophilic inflammation. EGPA preferentially affects certain organ systems, including the airways, peripheral nerves, heart, kidney, and gastrointestinal tract. Although gastrointestinal involvement, such as ulcerations, is common in EGPA, gastrointestinal perforation is relatively uncommon and is associated with a poor prognosis. Read More

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http://dx.doi.org/10.1016/j.carpath.2019.107193DOI Listing

Right sinus of Valsalva aneurysm.

Cardiovasc Pathol 2020 Jul - Aug;47:107209. Epub 2020 Feb 3.

Area of Pathology, Department of Woman and Child Health and Public Health, Fondazione Policlinico Universitario A. Gemelli IRCCS, Istituto di Anatomia Patologica, Università Cattolica Del Sacro Cuore, Rome, Italy. Electronic address:

Aneurysms in the sinuses of Valsalva (SVA) are the least frequent and occur due to a weakness in the aortic wall that forms part of the sinus. This causes dilatation and the formation of a blind pocket in one of the aortic sinuses (usually he right sinus and less frequently the posterior one). It may be congenital or acquired: in a congenital SVA, the condition is frequently associated with Marfan's syndrome or other connective tissue disorders; instead, acquired forms of sinus of Valsalva aneurysm are associated with infections (syphilis, bacterial endocarditis, and tuberculosis), atherosclerosis and medial cystic necrosis, traumatic and degenerative diseases, abuse of drugs or alcoholism. Read More

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http://dx.doi.org/10.1016/j.carpath.2020.107209DOI Listing
July 2020
2.336 Impact Factor

Chemotherapy-associated nonbacterial thrombotic endocarditis: A radiological mimicker of cardiac amyloidosis requiring histopathologic examination for definitive diagnosis.

Cardiovasc Pathol 2020 Jul - Aug;47:107210. Epub 2020 Feb 11.

Department of Internal Medicine, Division of Cardiovascular Medicine, University Hospitals Cleveland Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH, USA.

Nonbacterial thrombotic endocarditis is a form of a thrombotic angiopathy involving the endothelial lined endocardial surfaces of the heart which includes valves and the chamber walls. Underlying etiologies for nonbacterial thrombotic endocarditis include autoimmune diseases, hypercoagulable states, in the setting of certain malignant neoplasms, and physical injury. The pathogenesis for these processes is that of primary endothelial injury resulting in a thrombotic angiopathy. Read More

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http://dx.doi.org/10.1016/j.carpath.2020.107210DOI Listing

A rare case of post-infarction right ventricular rupture.

Cardiovasc Pathol 2020 Jul - Aug;47:107203. Epub 2020 Jan 15.

Forensic Medicine Department, Karapitiya Teaching Hospital, Galle, Sri Lanka. Electronic address:

A 62-year-old male patient was pronounced dead on admission to the tertiary care hospital. The victim had right ventricular STEMI three years ago. The autopsy showed pericardial tamponade due to the rupture of an acute myocardial infarction of the right ventricle. Read More

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http://dx.doi.org/10.1016/j.carpath.2020.107203DOI Listing
July 2020
2.336 Impact Factor

Prevention and management of allograft rejection in heart transplantation: are miR-126-5p and miR-126-5p-expressing mesenchymal stem cell exosomes the Ariadne's thread?

Cardiovasc Pathol 2020 Jul - Aug;47:107208. Epub 2020 Feb 1.

Division of Pediatrics and Neonatology, Moscati Hospital, Aversa, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.carpath.2020.107208DOI Listing
February 2020

Acute fatal myocarditis after a single dose of anti-PD-1 immunotherapy, autopsy findings: a case report.

Cardiovasc Pathol 2020 May - Jun;46:107202. Epub 2020 Jan 15.

Department of Pathology and The Ohio State University Wexner Medical Center, Columbus, OH, USA. Electronic address:

Nivolumab (PD-1 inhibitor) and Ipilimumab (CTLA-34 inhibitor) are both commonly used immune checkpoint inhibitor therapies for various cancers. Various adverse events are associated with these therapies, including hepatitis, nephritis, dermatitis, and myocarditis. It is believed these adverse events occur in part because modified cellular receptors lead to enhanced CD4 and CD8 lymphoproliferation. Read More

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http://dx.doi.org/10.1016/j.carpath.2020.107202DOI Listing

Giant cell arteritis in a patient with aortic dissection: a case report.

Cardiovasc Pathol 2020 May - Jun;46:107206. Epub 2020 Jan 23.

Department of Pathology and Biobank, National Cerebral and Cardiovascular Center, 6-1 Kishibe-shinmachi, Suita, 564-8565, Japan.

Aortic lesions, such as an aortic aneurysm, are known as a late complication that usually occurs several years after the onset of giant cell arteritis. Here, we report a rare case of large-vessel giant cell arteritis in a patient with aortic dissection. A 71-year-old man presented with acute back pain and was diagnosed with aortic dissection, Stanford type A, and he underwent elective ascending aortic replacement. Read More

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http://dx.doi.org/10.1016/j.carpath.2020.107206DOI Listing

Pathological changes secondary to pacing leads within the coronary veins.

Cardiovasc Pathol 2020 May - Jun;46:107197. Epub 2020 Jan 9.

Department of Cellular Pathology, Queen Elizabeth Hospital Birmingham, UK. Electronic address:

Changes within the Coronary veins secondary to pacing leads have not been described, this study assessed these changes in explanted hearts. Macroscopically fibrous sheaths formed around longstanding leads, leading to slit like channels for venous return in smaller veins. Histologically changes included bland fibrosis, a foreign body response to the lead, a chronic inflammatory response and inflammatory destruction of the media. Read More

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http://dx.doi.org/10.1016/j.carpath.2020.107197DOI Listing

Comparative pathology of human and canine myxomatous mitral valve degeneration: 5HT and TGF-β mechanisms.

Cardiovasc Pathol 2020 May - Jun;46:107196. Epub 2020 Jan 7.

Department of Surgery, Columbia Cardiovascular Institute and College of Physicians and Surgeons at Columbia University, New York, NY, USA. Electronic address:

Myxomatous mitral valve degeneration (MMVD) is a leading cause of valve repair or replacement secondary to the production of mitral regurgitation, cardiac enlargement, systolic dysfunction, and heart failure. The pathophysiology of myxomatous mitral valve degeneration is complex and incompletely understood, but key features include activation and transformation of mitral valve (MV) valvular interstitial cells (VICs) into an active phenotype leading to remodeling of the extracellular matrix and compromise of the structural components of the mitral valve leaflets. Uncovering the mechanisms behind these events offers the potential for therapies to prevent, delay, or reverse myxomatous mitral valve degeneration. Read More

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http://dx.doi.org/10.1016/j.carpath.2019.107196DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7078050PMC

Papillary fibroelastoma on pulmonary valve - Valve-sparing surgery of a cardiac tumor in a rare location.

Cardiovasc Pathol 2020 May - Jun;46:107195. Epub 2020 Jan 2.

Department of Radiology, First Faculty of Medicine, Charles University and General University Hospital in Prague, U Nemocnice 2, 128 00 Prague 2, Czech Republic. Electronic address:

We present images of a papillary fibroelastoma on a pulmonary valve - echocardiography, intraoperative images, macroscopic and microscopic images of the tumor in this uncommon location. Read More

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http://dx.doi.org/10.1016/j.carpath.2019.107195DOI Listing

Induction of aortic valve calcification by celecoxib and its COX-2 independent derivatives is glucocorticoid-dependent.

Cardiovasc Pathol 2020 May - Jun;46:107194. Epub 2019 Dec 19.

Nancy E. and Peter C. Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY, USA. Electronic address:

Background: Celecoxib, a selective cyclooxygenase-2 inhibitor, was recently associated with increased incidence of aortic stenosis and found to produce a valvular calcification risk in vitro. Several cyclooxygenase-2 independent celecoxib derivatives have been developed and identified as possible therapies for inflammatory diseases due to their cadherin-11 inhibitory functions. Potential cardiovascular toxicities associated with these cyclooxygenase-2 independent celecoxib derivatives have not yet been investigated. Read More

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http://dx.doi.org/10.1016/j.carpath.2019.107194DOI Listing

Syphilitic aortitis: still a current common cause of aneurysm of the tubular portion of ascending aorta.

Cardiovasc Pathol 2020 May - Jun;46:107175. Epub 2019 Oct 28.

Department of Cardiac Surgery, Baylor University Medical Center, Dallas, TX, USA.

Aortic syphilis today is infrequently diagnosed clinically. Described herein are findings in 5 women who had resection of a fusiform aneurysm of the tubular portion of ascending aorta, and examination of the wall of the aneurysm disclosed classic features of aortic syphilis. The 5 patients were among 36 who had ascending aortic operations at Baylor University Medical Center in Dallas in 2018 and early 2019. Read More

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http://dx.doi.org/10.1016/j.carpath.2019.107175DOI Listing

MiR-29a in mesenchymal stem cells inhibits FSTL1 secretion and promotes cardiac myocyte apoptosis in hypoxia-reoxygenation injury.

Cardiovasc Pathol 2020 May - Jun;46:107180. Epub 2019 Nov 19.

Department of Cardiology, Shenzhen University General Hospital, Shenzhen 518000, Guangdong Province, PR China. Electronic address:

Background: Mesenchymal stem cells (MSCs) are under consideration for myocardial ischemia-reperfusion (I/R) injury therapy, but their mechanism remains to be evaluated. In this article, we aimed to study the effects of the miR-29a/follistatin-like 1 axis in bone marrow-derived mesenchymal stem cells on modulating myocyte apoptosis after hypoxia-reoxygenation (H/R) injury.

Methods: An in vitro myocardial ischemia-reperfusion injury model of H9c2 cells was developed by hypoxia-reoxygenation injury. Read More

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http://dx.doi.org/10.1016/j.carpath.2019.107180DOI Listing

Heart failure in breast cancer survivors: implications of miR126?

Cardiovasc Pathol 2020 May - Jun;46:107189. Epub 2019 Dec 20.

Division of Pediatrics and Neonatology, Moscati Hospital, Aversa, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.carpath.2019.107189DOI Listing

Relationships between visceral/subcutaneous adipose tissue FABP4 expression and coronary atherosclerosis in patients with metabolic syndrome.

Cardiovasc Pathol 2020 May - Jun;46:107192. Epub 2019 Dec 6.

Department of Medical Genetics, Child Health Institute, Istanbul University, Istanbul, Turkey. Electronic address:

Background: Cytoplasmic fatty acid-binding proteins facilitate the transport of lipids to specific compartments in cells. Fatty acid-binding protein 4 (FABP4), also known as aP2 or A-FABP, plays a key role in the development of atherosclerosis, insulin resistance, obesity, and metabolic syndrome (MS). The FABP4 polymorphisms are associated with protein expression changes in vitro and metabolic and vascular alterations in vivo. Read More

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http://dx.doi.org/10.1016/j.carpath.2019.107192DOI Listing
June 2020
2.336 Impact Factor

Recurrent pericardial effusion with pericardial amyloid deposition: a case report and literature review.

Cardiovasc Pathol 2020 May - Jun;46:107191. Epub 2019 Dec 6.

Department of Surgical Pathology, Tokyo Women's Medical University, Tokyo, Japan.

Pericardial amyloidosis is a rare cause of pericardial effusion. Here, we report a case of recurrent pericardial effusion because of pericardial amyloid deposition. The patient was a man in his 40s admitted for pulmonary embolism. Read More

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http://dx.doi.org/10.1016/j.carpath.2019.107191DOI Listing

Clinicopathological manifestations of myocarditis in a heart failure population.

Cardiovasc Pathol 2020 Mar - Apr;45:107190. Epub 2019 Dec 2.

Center for Advanced Heart Failure, Cardiopulmonary Support and Transplantation Program, Memorial Hermann Heart & Vascular Institute, Memorial Hermann Hospital - Texas Medical Center, Houston, TX, USA.

Myocarditis continues to present challenges in diagnosis and management. The goal of this study is to determine the occurrence and manifestations of myocarditis in a heart failure (HF) population. The analyzed patients had acute or persistent HF and were referred over a 6-year period to a quaternary HF center for advanced HF therapies including mechanical circulatory support, left ventricular assist device (LVAD) implantation, and/or heart transplantation. Read More

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http://dx.doi.org/10.1016/j.carpath.2019.107190DOI Listing
June 2020
2.336 Impact Factor

A novel, rapid, and low cost method for preparing tissues with metallic stents for routine histology.

Cardiovasc Pathol 2020 Mar - Apr;45:107177. Epub 2019 Nov 15.

Intermountain Biorepository, Salt Lake City, UT, USA.

Background: Coronary artery stenting has become a common procedure and cardiovascular pathology specimens containing these metallic stents are accordingly becoming common. Histologic examination of stented vessels is imperative, but special techniques are needed due to the presence of metal within the tissue. We describe a rapid and inexpensive method for preparing stented vascular specimens for routine histology suitable for use in almost any histology laboratory. Read More

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http://dx.doi.org/10.1016/j.carpath.2019.107177DOI Listing

Moyamoya disease associated with fibromuscular dysplasia of intrapulmonary bronchial arteries-a case report.

Cardiovasc Pathol 2020 Mar - Apr;45:107182. Epub 2019 Nov 23.

Department of Neurosurgery, Charles University Faculty of Medicine and Faculty Hospital, Hradec Králové, Czech Republic.

A case is reported of a 40-year-old woman clinically diagnosed as moyamoya disease with associated fibromuscular dysplasia of intrapulmonary bronchial arteries incidentally revealed during autoptic examination. Moyamoya disease represents an idiopathic noninflammatory and nonatherosclerotic arterio-occlusive process of intracranial arteries. Prolonged brain ischemia leads to formation of tiny and fragile collaterals. Read More

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http://dx.doi.org/10.1016/j.carpath.2019.107182DOI Listing

Absent left atrial appendage: case report and review of the literature.

Cardiovasc Pathol 2020 Mar - Apr;45:107178. Epub 2019 Nov 18.

Department of Anesthesiology, University at Buffalo, Buffalo, NY, USA. Electronic address:

Congenital absence of left atrial appendage (LAA) is an extremely rare condition and is usually diagnosed incidentally in imaging intended for other purposes. Herein, we report a rare case of absent left atrial appendage in an 80-year-old gentleman who was candidate for radiofrequency catheter ablation procedure for atrial flutter rhythm in whom we observed the absence of left atrial appendage in echocardiographic examination. Computed tomography angiographic examination performed in the evaluation course of the patient was also confirmative of this finding. Read More

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http://dx.doi.org/10.1016/j.carpath.2019.107178DOI Listing
June 2020
2.336 Impact Factor

Cardiac varix: an example via a case report of a radiological mimicker of cardiac myxoma.

Cardiovasc Pathol 2020 Mar - Apr;45:107183. Epub 2019 Nov 26.

Department of Pathology, University Hospitals Cleveland Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH, USA. Electronic address:

Cardiac myxoma is the most frequently encountered primary neoplasm of the heart; however, other tumefactive lesions can share similar radiologic features. We present briefly the case of a 69-year-old man incidentally found to have a mobile right atrial mass that based on initial radiologic findings was considered to represent a myxoma. After pathologic examination, the lesion was determined instead to be a cardiac varix: an endocardial, blood filled cystic space lined by endothelium and considered to represent a dilated vein. Read More

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http://dx.doi.org/10.1016/j.carpath.2019.107183DOI Listing

Thoracic aortic dissection associated with involvement by small lymphocytic lymphoma/chronic lymphocytic leukemia: a possible underappreciated risk factor?

Cardiovasc Pathol 2020 Mar - Apr;45:107179. Epub 2019 Nov 18.

Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA. Electronic address:

We report a case of a 77-year-old man with small lymphocytic lymphoma/chronic lymphocytic leukemia (SLL/CLL) thought to be in remission who developed an acute type A thoracic aortic dissection despite no known risk factors for aortic dissection. Surgical pathology evaluation of the aorta specimen removed at surgery showed direct lymphocytic infiltration of the aortic adventitia and media in the region of the aortic dissection. The potential causative role and pathophysiologic mechanisms of SLL/CLL in aortic dissection are discussed. Read More

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http://dx.doi.org/10.1016/j.carpath.2019.107179DOI Listing

Ultrastructural effects of diabetes in the right atrium cardiomyocytes of elderly Wistar rats.

Cardiovasc Pathol 2020 Mar - Apr;45:107181. Epub 2019 Nov 19.

Laboratory of Morphological and Immunohistochemical Studies, São Judas Tadeu University, São Paulo, SP, Brazil; Department of Anatomy, Institute of Biomedical Sciences of University of São Paulo, São Paulo, SP, Brazil.

The present study aimed to evaluate the effects of diabetes on quantitative parameters of right atrial cardiomyocytes of elderly rats. Wistar rats (14 months of age) were divided into two groups: streptozotocin-diabetic rats (DG) and control rats (CG). The groups were sacrificed at 16 months. Read More

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http://dx.doi.org/10.1016/j.carpath.2019.107181DOI Listing

Fibrotic aortic valve disease after radiotherapy: an immunohistochemical study in breast cancer and lymphoma patients.

Cardiovasc Pathol 2020 Mar - Apr;45:107176. Epub 2019 Nov 15.

Department of Cardiothoracic Surgery, Amsterdam University Medical Center, University of Amsterdam, Heart Center, Amsterdam, the Netherlands. Electronic address:

Background: Radiation-associated aortic valve (AV) stenosis is frequently seen as a late sequela after thoracic radiotherapy (RT). Although the clinical relationship between thoracic radiotherapy and valvular dysfunction has been established, the process leading to accelerated aortic valve stenosis remains unclear. The aim of this study was to determine whether increased inflammatory cell infiltration, fibrosis, and calcification is present in aortic valves after radiotherapy at the time of aortic valve replacement. Read More

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http://dx.doi.org/10.1016/j.carpath.2019.107176DOI Listing

Comparison of heat monitoring-based myocardial protection strategy with classic myocardial protection method in isolated coronary artery bypass surgery patients.

Cardiovasc Pathol 2020 Mar - Apr;45:107161. Epub 2019 Nov 5.

Department of Histology, Bahçeşehir University Medicine Faculty, Istanbul, Turkey.

Objective: In this study, we aimed to compare patients who have a myocardial protection strategy based on myocardial temperature monitorization with those who had myocardial protection with conventional intermittent cardioplegia.

Methods: Twenty-six patients undergoing coronary artery bypass graft surgery were included into the study. Patients were prospectively grouped into two; myocardial protection based on temperature monitoring (group 1, n = 11) and those who had cardioplegia every 20 min (group 2, n = 15) during aortic cross-clamping. Read More

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http://dx.doi.org/10.1016/j.carpath.2019.107161DOI Listing