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    1512 results match your criteria Cardiovascular Pathology[Journal]

    1 OF 31

    A case of vascular Ehlers-Danlos Syndrome with a cardiomyopathy and multi-system involvement.
    Cardiovasc Pathol 2018 Apr 24;35:48-51. Epub 2018 Apr 24.
    University of Notre Dame, 32 Mouat Street, Fremantle, Western Australia, 6160. Electronic address:
    Ehlers-Danlos Syndrome comprises a heterogeneous group of heritable connective tissue disorders resulting from various gene mutations. We present an unusual case of vascular Ehlers-Danlos Syndrome with distinctive physical characteristics and a cardiomyopathy with features suggesting isolated left ventricular non-compaction. The cardiac features represent the first report of a cardiomyopathy associated with a mutation in the COL3A1 gene. Read More

    Molecular and cellular insights into the pathogenesis of coronary artery ectasia.
    Cardiovasc Pathol 2018 Apr 16;35:37-47. Epub 2018 Apr 16.
    University of Münster, Faculty of Medicine, Münster, Germany; Cells-in-Motion Cluster of Excellence (EXC 1003-CiM), University of Münster, Münster, Germany.
    Coronary artery ectasia describes a local or diffuse dilatation of the epicardial coronary arteries. This review summarizes the molecular and cellular mechanisms involved in the pathogenesis of coronary artery ectasia. Better identification of the pathophysiologic steps will shed light into the clinical significance and may have direct implications for the management strategies of this disease. Read More

    Long non-coding RNA CHRF facilitates cardiac hypertrophy through regulating Akt3 via miR-93.
    Cardiovasc Pathol 2018 Apr 11;35:29-36. Epub 2018 Apr 11.
    Department of Cardiology, The Affiliated Hospital of Qingdao University, Qingdao 266003, China. Electronic address:
    Background: Non-coding RNAs, including long non-coding RNAs (lncRNAs) and microRNAs (miRNAs), have been demonstrated as central mediators in cardiac hypertrophy responses. LncRNA cardiac hypertrophy related factor (CHRF) has been reported to be implicated in cardiac hypertrophy. However, the underlying mechanisms of CHRF have not been thoroughly elucidated. Read More

    Thromboembolic findings in patients with heart failure at autopsy.
    Cardiovasc Pathol 2018 Apr 13;35:23-28. Epub 2018 Apr 13.
    Heart Institute (InCor) do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo -, São Paulo, Brazil. Electronic address:
    Background: The risk of thromboembolic events is increased in patients with heart failure (HF); however, few studies have reported thromboembolic findings in HF patients who have undergone autopsy.

    Methods And Results: We reviewed 1457 autopsies (January 2000/July 2006) and selected 595 patients with HF. We studied the occurrence of thromboembolic events in patients' autopsy reports. Read More

    New morphological classification of congenital quadricuspid aortic valve and its histopathologic features.
    Cardiovasc Pathol 2018 Apr 6;35:8-11. Epub 2018 Apr 6.
    Department of Biotechnology and Pharmaceutical Technology, Yuanpei University of Medical Technology, Hsin Chu, Taiwan. Electronic address:
    We report a 52-year-old male patient who had a quadricuspid aortic valve (QAV) associated with aortic regurgitation (AR) and left ventricular hypertrophy (LVH). A new accessory cusp (ACC) with maximum thickness than other cusps was located between right coronary cusp (RCC) and left coronary cusp (LCC). The histopathological features revealed markedly thickened and distorted cusp architecture with fibrosis and/or myxomatous degeneration in both non-coronary cusp (NCC) and ACC. Read More

    Thrombospondin-4 mediates cardiovascular remodelling in angiotensin II-induced hypertension.
    Cardiovasc Pathol 2018 Apr 7;35:12-19. Epub 2018 Apr 7.
    Department of Biomedical Engineering & Physics, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands. Electronic address:
    Thrombospondin 4 (TSP-4) expression is induced in the heart and vasculature under pathological conditions, including myocardial infarction, myocardial pressure overload, and hypertension. TSP-4 is linked to remodelling processes, where it may affect extracellular matrix protein organization. In previous work, we studied the role of TSP-4 in small arteries during hypertension using Ang II-treated Thrombospondin 4 knockout (Thbs4) mice. Read More

    Lymphocyte and monocyte subpopulations in severe aortic stenosis at the time of surgical intervention.
    Cardiovasc Pathol 2018 Apr 7;35:1-7. Epub 2018 Apr 7.
    Institute of Cardiology, Jagiellonian University Medical College, Krakow, Poland; The John Paul II Hospital, Krakow, Poland.
    Introduction: Aortic stenosis (AS) is the most common acquired valvular heart disease in adults. Immune system involvement becomes evident during AS development. We sought to investigate the role of different circulating lymphocyte and monocyte subpopulations, with focus on CD4CD8 and natural killer T (NKT) cells, in AS. Read More

    Cardiomyocytes have mosaic patterns of protein expression.
    Cardiovasc Pathol 2018 May - Jun;34:50-57. Epub 2018 Mar 24.
    Department of Pathology, Johns Hopkins School of Medicine, Baltimore, MD, USA. Electronic address:
    Skeletal myocytes have well-established fast and slow twitch fibers with unique gene and protein specific expression patterns. By immunohistochemical staining, these show a mosaic pattern across myocytes. We hypothesized cardiac myocytes may behave similarly where some proteins are differentially expressed between mature cardiomyocytes. Read More

    Five chambered heart: case of a huge left atrial appendage aneurysm.
    Cardiovasc Pathol 2018 May - Jun;34:43-45. Epub 2018 Mar 6.
    Cardiac Rehabilitation Research Center, Cardiovascular Research Institute, Isfahan University of Medicine Sciences, Isfahan, Iran. Electronic address:
    Aneurysmal enlargement of the left atrial appendage is an extremely rare pathology and can predispose to adverse events, including cardiac arrest, respiratory distress, arrhythmia, heart failure, systemic thromboembolism, or rupture. It is usually diagnosed incidentally or after the occurrence of atrial tachyarrhythmias or thrombotic events in the second to fourth decades of life. We describe a rare case of a symptomatic giant congenital left atrial appendage aneurysm (LAAA) in a 26-year-old man presenting with neurologic event, in whom surgical resection of the aneurysm was successfully performed. Read More

    Coxiella burnetii endocarditis on bioprosthetic aortic valve, with peripheral arterial embolism.
    Cardiovasc Pathol 2018 May - Jun;34:38-39. Epub 2018 Feb 16.
    Department of Nephrology, AP-HP, Hôpital Européen Georges Pompidou, F-75015 Paris, France.
    Acute limb ischemia related to Coxiella burnetii endocarditis is rare. We report an original case of a 68-year-old man hospitalized for recurrent acute left limb ischemia in a context of atrial flutter, which revealed C. burnetii endocarditis. Read More

    Increased Calcific Aortic Valve Disease in response to a diabetogenic, procalcific diet in the LDLrApoB mouse model.
    Cardiovasc Pathol 2018 May - Jun;34:28-37. Epub 2018 Feb 15.
    Department of Bioengineering, University of Washington, Seattle, WA 98195. Electronic address:
    Objective: Calcific aortic valve disease (CAVD) is a major cause of aortic stenosis (AS) and cardiac insufficiency. Patients with type II diabetes mellitus (T2DM) are at heightened risk for CAVD, and their valves have greater calcification than nondiabetic valves. No drugs to prevent or treat CAVD exist, and animal models that might help identify therapeutic targets are sorely lacking. Read More

    Immunophenotypic analysis of the chronological events of tissue repair in aortic medial dissections.
    Cardiovasc Pathol 2018 May - Jun;34:9-14. Epub 2018 Feb 10.
    Dept. of Pathology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105, AZ, Amsterdam, the Netherlands. Electronic address:
    Acute medial dissection of aorta can occur in the context of a sudden and unexpected death. For medico-legal reasons it is important to estimate as accurately the histological age of dissections. We evaluated the additional value of a systematic application of immunohistochemistry, compared with conventional histology only, in determining chronological steps of injury and repair. Read More

    Papillary muscles of right ventricle-morphological variations and its clinical relevance.
    Cardiovasc Pathol 2018 May - Jun;34:22-27. Epub 2018 Feb 9.
    Department of Anatomy, Institute of Post Graduation Medical Education & Research, West Bengal, India. Electronic address:
    Introduction: Papillary muscle plays an important role in stabilizing the position of the tricuspid valve. Several pathologies can result in anatomical and functional abnormalities of the papillary muscles. The aim of the study is to deliberate the morphometry of papillary muscles in tricuspid valve and to analyze with the eminent research works previously done. Read More

    Endomyocardial biopsy in differential diagnosis between arrhythmogenic right ventricular cardiomyopathy and dilated cardiomyopathy: an in vitro simulated study.
    Cardiovasc Pathol 2018 May - Jun;34:15-21. Epub 2018 Feb 14.
    State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, 167A Beilishi Road, Xi Cheng District, Beijing, 100037, P.R. China. Electronic address:
    Arrhythmogenic right ventricular cardiomyopathy (ARVC) and dilated cardiomyopathy (DCM), despite being two dramatically different entities, have overlapping phenotypes. As it is easy to misdiagnose between ARVC and DCM, there is a need to establish a new differential diagnostic parameter to differentiate the two. We investigated the utility of endomyocardial biopsy (EMB) for the differential diagnosis, and our study had three aims. Read More

    Blocking Wnt5a signaling decreases CD36 expression and foam cell formation in atherosclerosis.
    Cardiovasc Pathol 2018 May - Jun;34:1-8. Epub 2018 Feb 21.
    Department of Biomedical Sciences, Heritage College of Osteopathic Medicine, Ohio University, Athens, Ohio, USA; The Diabetes Institute, Ohio University, Athens, Ohio, USA; Molecular and Cellular Biology Graduate Program, Ohio University, Athens, Ohio, USA. Electronic address:
    Background And Aims: Wnt5a is a highly studied member of the Wnt family and recently has been implicated in the pathogenesis of atherosclerosis, but its precise role is unknown. Foam cell development is a critical process to atherosclerotic plaque formation. In the present study, we investigated the role of noncanonical Wnt5a signaling in the development of foam cells. Read More

    Pathogenesis of aortic wall complications in Marfan syndrome.
    Cardiovasc Pathol 2018 Mar - Apr;33:62-69. Epub 2018 Feb 2.
    Department of Anatomy and Embryology, Leiden University Medical Center, Leiden, the Netherlands; Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands.
    Background: Patients with Marfan (MFS) syndrome and patients with a bicuspid aortic valve (BAV) are more prone to develop aortic dilation and dissection compared to persons with a tricuspid aortic valve (TAV). To elucidate potential common as well as distinct pathways of clinical relevance, we compared the histopathological substrates of aortic pathology.

    Patient And Methods: Ascending aortic wall specimen were divided in five groups: BAV (n=36) and TAV (n=23) without and with dilation and non-dilated MFS (n=8). Read More

    IL-6 expression is correlated with increased T-cell proliferation and survival in the arterial wall in giant cell arteritis.
    Cardiovasc Pathol 2018 Mar - Apr;33:55-61. Epub 2018 Jan 9.
    Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, British Columbia, Canada. Electronic address:
    Giant cell arteritis (GCA) is the most common vasculitis in adults affecting large and medium-sized arteries. IL-6 and T cell accumulation within the arterial wall contribute to the pathogenesis of GCA, and blockade of IL-6 activity is efficacious in its treatment. We examined the relationship between levels of IL-6 expression and immunological processes that control the expansion of T cells in GCA-positive temporal artery biopsies. Read More

    Clinicopathologic features and outcomes of primary cardiac tumors: a 16-year-experience with 212 patients at a Chinese medical center.
    Cardiovasc Pathol 2018 Mar - Apr;33:45-54. Epub 2018 Jan 6.
    Department of Pathology, The Affiliated Hospital of Qingdao University, 16 Jiangsu Road, Qingdao 266003, China. Electronic address:
    Primary cardiac tumors are uncommon, and the majority of them are benign which are curable but can cause significant morbidity if not diagnosed and treated in a timely fashion. The objective of this study was to review the clinicopathologic features and surgical outcomes of patients with primary cardiac tumors in a single medical center in China. We have retrospectively reviewed 212 consecutive adult patients who underwent surgical resection of primary cardiac tumors at our center from January of 2001 to June of 2017. Read More

    A case of vasculopathy of unknown etiology associated with fatal hydrops fetalis and review of the literature on intimomedial mucoid degeneration.
    Cardiovasc Pathol 2018 Mar - Apr;33:39-44. Epub 2018 Jan 9.
    Penn State Health Milton S. Hershey Medical Center.
    Non-immune hydrops fetalis (NIHF) has a high mortality rate [1]. Many etiologies of NIHF have been identified, including cardiovascular abnormalities, severe anemia, and genetic defects. In patients with cardiovascular etiology, structural malformations lead to fluid accumulation resulting in increased intravascular hydrostatic pressure. Read More

    Surgical pathology of subaortic septal myectomy: histology skips over clinical diagnosis.
    Cardiovasc Pathol 2018 Mar - Apr;33:32-38. Epub 2018 Jan 3.
    Cardiology Department, Hospital dos Lusíadas, Lisboa; Faculdade de Medicina, Universidade de Lisboa.
    Background: Subaortic septal myectomy is usually performed to mitigate obstruction in patients with the obstructive form of hypertrophic cardiomyopathy (HCM) or in those with congenital subaortic stenosis. Moreover, it is combined with aortic valve replacement in patients with severe aortic valve stenosis (SAS) and asymmetrical septal hypertrophy causing concomitant left ventricular outflow tract obstruction. When both conditions coexist, it is conceptually difficult to identify a cardiomyopathy beyond an adaptive myocardial hypertrophy, strictly related to pressure overload. Read More

    Characteristics, survival and incidence rates and trends of primary cardiac malignancies in the United States.
    Cardiovasc Pathol 2018 Mar - Apr;33:27-31. Epub 2017 Dec 28.
    Pharmacology Department, Suez Canal University, Ismailia, Egypt; Department of Ophthalmology and Micro-Technology, Yokohama City University, Yokohama, Japan.
    Background: The available literature on the incidence, management and prognosis of primary malignant cardiac tumors [PMCTs] is limited to single-center studies, prone to small sample size and referral bias. We used data from the Surveillance, Epidemiology, and End Results [SEER]-18 registry (between 2000 and 2014) to investigate the distribution, incidence trends and the survival rates of PMCTs.

    Methods: We used SEER*Stat (version 8. Read More

    Survival kinase-dependent pathways contribute to gender difference in the response to myocardial ischemia-reperfusion and ischemic post-conditioning.
    Cardiovasc Pathol 2018 Mar - Apr;33:19-26. Epub 2017 Dec 28.
    Centro de Investigaciones Cardiovasculares ¨Dr Horacio E. Cingolani¨, CCT-CONICET, Universidad Nacional de La Plata, La Plata, Argentina. Electronic address:
    The response to ischemia/reperfusion and the effects of ischemic post-conditioning (IPC) are sex-dependent, but the mechanisms have not been clarified. Male (M) and female (F) rat hearts isolated and perfused using the Langendorff technique were subject to 30 min of global ischemia (GI) and 60 min reperfusion (R). In IPC hearts, three cycles of 30-sec GI/30-sec R were applied at the beginning of R. Read More

    Rare case of infective endocarditis involving mitral annular calcification leading to hemopericardium and sudden cardiac death: a case report.
    Cardiovasc Pathol 2018 Mar - Apr;33:16-18. Epub 2017 Dec 5.
    McMaster University, McMaster University Medical Centre, 1200 Main St. West, Hamilton, ON, L8Z 3N5, Canada; Hamilton Health Sciences, Hamilton General Hospital, 237 Barton St. East, Hamilton, ON, L8L 2X2, Canada.
    We present a unique case of a 76-year-old female who had sudden cardiac death due to hemopericardium. Post mortem examination revealed infective endocarditis(IE) superimposing on mitral annulus calcification(MAC) leading to abscess formation, epicardial fistulation and hemopericardium. MAC is currently considered a relatively benign condition of the elderly [1], however evidence suggests there are severe consequences when these patients develop IE. Read More

    TUG1 knockdown ameliorates atherosclerosis via up-regulating the expression of miR-133a target gene FGF1.
    Cardiovasc Pathol 2018 Mar - Apr;33:6-15. Epub 2017 Dec 2.
    Department of Cardiology, Huaihe Hospital of Henan University, Kaifeng, 475000, China. Electronic address:
    Background: Long non-coding RNAs (lncRNAs) have been revealed to participate in the pathological events associated with atherosclerosis. However, the exact role of lncRNA taurine-up-regulated gene 1 (TUG1) and its possible molecular mechanism in atherosclerosis remain unidentified.

    Methods: High-fat diet (HFD)-treated ApoE mice were used as an in vivo model of atherosclerosis. Read More

    Cardiac sarcoidosis presenting as arrhythmogenic right ventricular cardiomyopathy/dysplasia with ventricular aneurysms: a case report.
    Cardiovasc Pathol 2018 Mar - Apr;33:1-5. Epub 2017 Nov 10.
    Center for Advanced Heart Failure, The University of Texas Health Science Center at Houston/Memorial Hermann Hospital - Texas Medical Center, 6400 Fannin St, Suite 2350, Houston, TX 77030. Electronic address:
    A 70-year old Caucasian man with recurrent ventricular tachycardia and progressive biventricular failure attributed to arrhythmogenic right ventricular cardiomyopathy/dysplasia was evaluated for heart transplantation. Cardiac ventriculography revealed an abnormal left ventricle with five saccular aneurysms. Heart transplantation was performed. Read More

    Betaglycan (TGFBR3) up-regulation correlates with increased TGF-β signaling in Marfan patient fibroblasts in vitro.
    Cardiovasc Pathol 2018 Jan - Feb;32:44-49. Epub 2017 Nov 4.
    Department of Vascular Surgery, Amsterdam Cardiovascular Sciences, VU University Medical Center, Amsterdam, The Netherlands; Department of Physiology, Amsterdam Cardiovascular Sciences, VU University Medical Center, Amsterdam, The Netherlands. Electronic address:
    Background: Marfan syndrome (MFS), a congenital connective tissue disorder leading to aortic aneurysm development, is caused by fibrillin-1 (FBN1) gene mutations. Transforming growth factor beta (TGF-β) might play a role in the pathogenesis. It is still a matter of discussion if and how TGF-β up-regulates the intracellular downstream pathway, although TGF-β receptor 3 (TGFBR3 or Betaglycan) is thought to be involved. Read More

    Changes in neurofilament 200 and tyrosine hydroxylase expression in the cardiac innervation of diabetic rats during aging.
    Cardiovasc Pathol 2018 Jan - Feb;32:38-43. Epub 2017 Nov 16.
    Laboratory for Neurocardiology, Department of Anatomy, Histology and Embryology, University of Split School of Medicine, Soltanska 2, 21000 Split, Croatia; Laboratory for Early Human Development, Department of Anatomy, Histology and Embryology, University of Split School of Medicine, Soltanska 2, 21000 Split, Croatia; Laboratory for Microscopy, Department of Anatomy, Histology and Embryology, University of Split School of Medicine, Soltanska 2, 21000 Split, Croatia. Electronic address:
    Changes in sensory and sympathetic innervation during diabetes mellitus (DM) can be a predictor of arrhythmias, silent myocardial ischemia, and chronic heart failure, but knowledge about these changes is still unsatisfactory. We analyzed whether prolonged DM induces changes in density of sensory and sympathetic nerve terminals of rat's heart and whether it contributes to cardiomyopathy during aging. DM was induced by i/p injecting 55 mg/kg streptozotocin to male Sprague-Dawley rats, while a control group received a citrate buffer. Read More

    Comorbidities in relation to fatality of first myocardial infarction.
    Cardiovasc Pathol 2018 Jan - Feb;32:32-37. Epub 2017 Nov 14.
    Unit of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
    Introduction: Present knowledge concerning potential associations between comorbidities and the fatality of a first myocardial infarction (MI) is limited.

    Aim: To identify comorbidities in 45-70-year-old individuals who suffered a first MI and died within 7 days in Stockholm County from 1992-1994. In addition, to assess how each of the comorbidities identified, as well as the number of hospitalizations during the 10-year period prior to the MI, was associated with MI fatality. Read More

    Malignant lymphoma arising in cardiac myxoma, presenting with peripheral arterial emboli.
    Cardiovasc Pathol 2018 Jan - Feb;32:26-29. Epub 2017 Oct 14.
    Department of Pathology, Severance hospital, Yonsei University College of Medicine, Seoul, Republic of Korea. Electronic address:
    Composite tumors of cardiac myxoma and malignant lymphoma are extremely rare, with 11 of such cases reported in the literature. A 44-year-old man presented to us with abrupt right lower leg pain. A computed tomography angiogram revealed segmental obstruction of the right common femoral artery, and embolectomy was performed. Read More

    Clearance of plasmin-PN-1 complexes by vascular smooth muscle cells in human aneurysm of the ascending aorta.
    Cardiovasc Pathol 2018 Jan - Feb;32:15-25. Epub 2017 Oct 24.
    UMR 1148, Laboratory for Vascular Translational Science, Inserm; Paris7 Denis Diderot University. Electronic address:
    Plasminogen is a circulating zymogen which enters the arterial wall by radial, transmural hydraulic conductance, where it is converted to plasmin by tissue plasminogen activator t-PA on an activation platform involving S100A4 on the vascular smooth muscle cell (vSMC) membrane. Plasmin is involved in the progression of human thoracic aneurysm of the ascending aorta (TAA). vSMCs protect the TAA wall from plasmin-induced proteolytic injury by expressing high levels of antiproteases. Read More

    Adventitial tertiary lymphoid organ classification in human atherosclerosis.
    Cardiovasc Pathol 2018 Jan - Feb;32:8-14. Epub 2017 Sep 7.
    Department of Cardiology, University of Heidelberg, Germany; DZHK (German Centre for Cardiovascular Research), partner site Heidelberg, Mannheim, Germany. Electronic address:
    Background: Atherosclerosis is a chronic inflammatory disease of the arterial wall. Adjacent to lamina intima lesion progression, a cellular compound develops in the lamina adventitia, defined as tertiary lymphoid organs (TLO) in mice. But in human system, it remains unknown whether these adventitial cellular accumulations represent these highly organized immunological structures. Read More

    Globular chitosan treatment of bovine jugular veins: evidence of anticalcification efficacy in the subcutaneous rat model.
    Cardiovasc Pathol 2018 Jan - Feb;32:1-7. Epub 2017 Sep 14.
    «E. Meshalkin National Medical Research Center» of the Ministry of Health of the Russian Federation, 15 Rechkunovskaya Str., 630055 Novosibirsk, Russian Federation.
    Vascular xenografts are widely used in cardiovascular surgery as an alternative to autologous vessels and vascular allografts. Calcification is one of the main drawbacks of vascular grafts, especially among young patients and children. Among different anticalcification approaches, chitosan emerges as a highly promising candidate due to its versatility, natural origin, and biocompatibility. Read More

    Kaempferol alleviates ox-LDL-induced apoptosis by up-regulation of autophagy via inhibiting PI3K/Akt/mTOR pathway in human endothelial cells.
    Cardiovasc Pathol 2017 Nov - Dec;31:57-62. Epub 2017 Aug 10.
    Department of Cardiothoracic Surgery, Huaihe Hospital of Henan University, Kaifeng, 475000, China. Electronic address:
    Oxidized low-density lipoprotein (ox-LDL) has been reported to induce apoptosis of endothelial cells (ECs) and contribute to the progression of atherosclerosis. Kaempferol has been shown to possess antiatherosclerotic effect. The aim of the present study was to evaluate the effect of kaempferol on ox-LDL-induced apoptosis of human umbilical vein endothelial cells (HUVECs) and its possible molecular basis. Read More

    Primary cardiac diffuse large B-cell lymphoma with concurrent high MYC and BCL2 expression in an immunocompetent Chinese elderly woman.
    Cardiovasc Pathol 2017 Nov - Dec;31:54-56. Epub 2017 Aug 4.
    İzmir International Biomedicine and Genome Institute (iBG-izmir), Dokuz Eylul University, İzmir, Turkey; Department of Medical Biology, Faculty of Medicine, Dokuz Eylul University, İzmir, Turkey.
    Primary cardiac lymphoma is a rare type of extranodal lymphoma that involves only heart and/or pericardium. It is usually observed in immunodeficient people. However, immunocompetent patients may also suffer from this disease. Read More

    Tanshinone IIA ameliorated endothelial dysfunction in rats with chronic intermittent hypoxia.
    Cardiovasc Pathol 2017 Nov - Dec;31:47-53. Epub 2017 Jun 30.
    Department of Physiology, Hebei University of Chinese Medicine, Shijiazhuang, Hebei, People's Republic of China. Electronic address:
    Chronic intermittent hypoxia (CIH) during repetitive airflow cessations may cause endothelial dysfunction. Tanshinone IIA (Tan IIA) has been used to treat various circulatory disturbance-related diseases because of its pharmacological actions, including vasodilation. However, the mechanism of the effect of its vasodilation is not well established. Read More

    Aortic fibromuscular dysplasia complicated by dissection: a case report and review of literature.
    Cardiovasc Pathol 2017 Nov - Dec;31:41-46. Epub 2017 Aug 9.
    Department of Pathology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan. Electronic address:
    Fibromuscular dysplasia (FMD) is an idiopathic, segmental, nonatherosclerotic, non-inflammatory vascular disease, which is often complicated by the occurrence of dissection. Although it is known to occur in all arteries, aortic involvement is relatively rare. To date, 33 cases of aortic FMD have been reported in available English literature, among which only three cases have been complicated by the occurrence of dissection. Read More

    Four new cases of pediatric thoracic aortic aneurysm (TAA) with review of the molecular genetic basis, utilizing the newly published consensus nomenclature.
    Cardiovasc Pathol 2017 Nov - Dec;31:34-40. Epub 2017 Jul 27.
    Emory University School of Medicine, Department of Pediatric Pathology, Atlanta, GA, USA. Electronic address:
    The majority of thoracic aortic aneurysms (TAA) in the pediatric population are due to post repair etiology (iatrogenic). Although rare, underlying inheritable disease and congenital cardiac anomalies represent the most common non-iatrogenic cause of TAA among patients in this age group (1-21 years of age). Herein, we present a case series of 9aortic aneurysms with varying underlying etiology. Read More

    Reduced activin receptor-like kinase 1 activity promotes cardiac fibrosis in heart failure.
    Cardiovasc Pathol 2017 Nov - Dec;31:26-33. Epub 2017 Jul 18.
    Molecular Cardiology Research Institute and Division of Cardiology, Department of Medicine, Tufts Medical Center, 800 Washington Street, Boston, MA, 02111, USA. Electronic address:
    Introduction: Activin receptor-like kinase 1 (ALK1) mediates signaling via the transforming growth factor beta-1 (TGFβ1), a pro-fibrogenic cytokine. No studies have defined a role for ALK1 in heart failure.

    Hypothesis: We tested the hypothesis that reduced ALK1 expression promotes maladaptive cardiac remodeling in heart failure. Read More

    Hereditary multiple exostoses as a novel cause of bilateral popliteal artery aneurysms in the elderly.
    Cardiovasc Pathol 2017 Nov - Dec;31:20-25. Epub 2017 Jul 8.
    Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. Electronic address:
    Hereditary multiple exostoses (HME) is a genetic condition characterized by the development of multiple osteochondromas during childhood and adolescence. On rare occasions, these bony tumors can be associated with vascular injury, most commonly involving the popliteal artery. Such patients typically present with vascular complications in adolescence and young adulthood. Read More

    Complete step section microscopic study of a Swan-Ganz catheter-related pulmonary artery rupture: a frequently lethal complication that to our knowledge has not had a comprehensive microscopic examination: case report and literature review.
    Cardiovasc Pathol 2017 Nov - Dec;31:17-19. Epub 2017 Jul 4.
    Department of Pathology, University of Texas Medical Branch, 301 University Blvd., Galveston, TX 77555.
    Background: Introduced in 1970, the Swan-Ganz catheter (SGC) soon became widely used because of its unique usefulness in managing intensive care patients. Unfortunately, SGC usage was complicated by pulmonary artery rupture (PAR) with a 50% mortality rate that led to a near banning of the SCG in the late 1980s. Increasing knowledge and decreasing incidence of SGC-related PARs (SGPARs) led to the current feeling that the present SGPAR incidence is now low enough to tolerate given the lives saved by SGC usage. Read More

    Cardiac arrest due to ventricular fibrillation in a 23-year-old woman with broken heart syndrome.
    Cardiovasc Pathol 2017 Sep - Oct;30:78-81. Epub 2017 Jun 30.
    VCU Pauley Heart Center, Virginia Commonwealth University, Richmond, VA, USA. Electronic address:
    Broken heart syndrome, also known as takotsubo cardiomyopathy, is a syndrome characterized by a transient regional systolic dysfunction of the left ventricle associated to a psychological stress. We herein describe a case of a 23-year-old female habitual marijuana user who was resuscitated after cardiac arrest and then diagnosed with midventricular stress cardiomyopathy complicated by subendocardial hemorrhage. We discuss this unique pathological finding, the incidence of arrhythmias in this syndrome, and the possible relation with chronic cannabis and tobacco use. Read More

    Increased β-catenin accumulation and nuclear translocation are associated with concentric hypertrophy in cardiomyocytes.
    Cardiovasc Pathol 2017 Nov - Dec;31:9-16. Epub 2017 Jul 12.
    Graduate Institute of Basic Medical Science, China Medical University, Taichung 40402, Taiwan; Graduate Institute of Chinese Medical Science, China Medical University, Taichung 40402, Taiwan; Department of Health and Nutrition Biotechnology, Asia University, Taichung 41354, Taiwan; Faculty of Applied Sciences, Ton Duc Thang University, Tan Phong Ward, District 7, 700000 Ho Chi Minh City, Vietnam. Electronic address:
    Defective Wnt/β-Catenin signaling, activated under various pathological conditions, can result in cardiac and vascular abnormalities. In the present study, the possible role of β-catenin over expression during cardiac hypertrophy was investigated. Ten samples from hearts of human patients with acute infarction, and granulation tissue from 20 patients and 10 from normal ones were collected in order to investigate roles of β-catenin in cardiac hypertrophy. Read More

    Intimal sarcoma of the pulmonary trunk showing broad intimal extension and focal chondrosarcomatous differentiation: an autopsy case.
    Cardiovasc Pathol 2017 Nov - Dec;31:5-8. Epub 2017 Jul 8.
    Department of Pathology, Japan Self-Defense Forces Central Hospital, Tokyo, Japan; Health Care Center, Japan Self-Defense Forces Central Hospital, Tokyo, Japan.
    We report an autopsy case of intimal sarcoma arising in the pulmonary artery with focal chondrosarcomatous differentiation. A 77-year-old woman presented with a thrombosis-like mass in the pulmonary trunk and underwent endarterectomy. Macroscopically, solid and myxomatous tumor expanded to the pulmonary valve and bilateral main pulmonary arteries. Read More

    Extranodal Rosai-Dorfman disease arising in the heart: clinical course and review of literature.
    Cardiovasc Pathol 2017 Nov - Dec;31:1-4. Epub 2017 Jul 4.
    Department of Pathology, Downstate Medical Center, State University of New York, Brooklyn, NY 11203; Department of Cell Biology, Downstate Medical Center, State University of New York, Brooklyn, NY 11203. Electronic address:
    Rosai-Dorfman disease (RDD), also known as sinus histiocytosis with massive lymphadenopathy, is a nonmalignant disease of unknown etiology. It may present as bilateral, massive, painless cervical lymphadenopathy; however, one third of the cases have extranodal involvement. Extranodal sites include soft tissue, skin, upper respiratory and gastrointestinal tracts, and central nervous system, with head and neck being the most common. Read More

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