1,565 results match your criteria Cardiovascular Pathology[Journal]


Description of the aortic root anatomy in relation to transcatheter aortic valve implantation.

Cardiovasc Pathol 2019 Jan 21;40:19-23. Epub 2019 Jan 21.

Department of Anatomy, Post Graduate Institute of Medical Education and Research, Chandigarh, 160012, India.

Introduction: Transcatheter aortic valve implantation (TAVI) has emerged as a less invasive treatment than surgical aortic valve replacement in patients with aortic stenosis. Understanding the anatomy of aortic valve complex may help in optimal positioning of prosthetic valve and circumvent complications that can arise during its implantation.

Material And Methods: The anatomy of aortic root was studied in 30 formalin-fixed cadavers. Read More

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http://dx.doi.org/10.1016/j.carpath.2019.01.005DOI Listing
January 2019

Iatrogenic embolization following cardiac intervention: postmortem analysis of 110 cases.

Cardiovasc Pathol 2019 Jan 19;40:12-18. Epub 2019 Jan 19.

University of British Columbia, Pathology & Laboratory Medicine, Vancouver, BC, Canada; Vancouver General Hospital, Neuropathology, Vancouver, BC, Canada; St. Paul's Hospital, Pathology & Laboratory Medicine, Vancouver, BC, Canada. Electronic address:

Introduction: Iatrogenic embolization following cardiac investigative procedures may result from hydrophilic polymer emboli (HPE) from catheter valve and vessel wall calcifications, and air embolism from open heart surgery. This retrospective clinical pathologic analysis was undertaken to ascertain the frequency and extent of these potentially fatal complications.

Methods: This retrospective clinical pathologic autopsy analysis with premortem diagnostic imaging correlation identified 110 individuals who had undergone endovascular procedures between 2010 and 2016 within 90 days of death and followed by hospital autopsy. Read More

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http://dx.doi.org/10.1016/j.carpath.2019.01.003DOI Listing
January 2019
1 Read

Cardiac iron overload following liver transplantation in patients without hereditary hemochromatosis or severe hepatic iron deposition.

Cardiovasc Pathol 2019 Jan 3;40:7-11. Epub 2019 Jan 3.

Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA. Electronic address:

Background: Cardiac iron overload following liver transplantation in patients without hemochromatosis but with severe hepatic iron deposition has been reported to result in heart failure and/or death in case reports and small case series. However, the frequency and causes of cardiac iron overload following liver transplantation and its relationship to cardiac dysfunction in patients without severe hepatic iron deposition are unclear.

Methods: The primary inclusion criteria for this study were liver transplantation followed by autopsy or cardiac transplantation within 1 year. Read More

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http://dx.doi.org/10.1016/j.carpath.2018.12.008DOI Listing
January 2019
1 Read

Distinct molecular signature of phospholamban p.Arg14del arrhythmogenic cardiomyopathy.

Cardiovasc Pathol 2018 Dec 21;40:2-6. Epub 2018 Dec 21.

University of Groningen, University Medical Center Groningen, Department of Pathology, Groningen, The Netherlands.

Phospholamban (PLN) p.Arg14del cardiomyopathy is characterized by a distinct arrhythmogenic biventricular phenotype that can be predominantly left ventricular, right ventricular, or both. Our aim was to further elucidate distinct features of this cardiomyopathy with respect to the distribution of desmosomal proteins observed by immunofluorescence (IF) in comparison to desmosomal arrhythmogenic cardiomyopathy and co-existent genetic variants. Read More

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http://dx.doi.org/10.1016/j.carpath.2018.12.006DOI Listing
December 2018
2 Reads

Arthur Stanley Kent and accessory muscular atrioventricular connections.

Cardiovasc Pathol 2019 Jan 16;40. Epub 2019 Jan 16.

Institute of Genetic Medicine, Newcastle University, Newcastle-upon-Tyne, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.carpath.2019.01.001DOI Listing
January 2019

Intraesophageal aortopulmonary collateral artery occlusion in an infant with Tetralogy of Fallot and flow-dependent major aortopulmonary collateral arteries.

Cardiovasc Pathol 2019 Jan 9;39:74-76. Epub 2019 Jan 9.

Patients with flow-dependent aortopulmonary collateral arteries often exhibit tenuous clinical statuses. Here we present an infant with Tetralogy of Fallot with pulmonary atresia (TOF-PA) and major aortopulmonary collateral arteries (MAPCAs) who experienced clinically significant oxygen desaturations during feedings. These frequent episodes were attributed to gastroesophageal reflux. Read More

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http://dx.doi.org/10.1016/j.carpath.2018.12.009DOI Listing
January 2019
1 Read

Eosinophilic granulomatosis with polyangiitis in a continuous flow left ventricular assist device patient: a case report and review of literature.

Cardiovasc Pathol 2018 Dec 28;39:70-73. Epub 2018 Dec 28.

Department of Pathology and Laboratory Medicine, The University of Texas Health Science Center at Houston, Houston, TX, USA.

Eosinophilic granulomatosis with polyangiitis (EGPA), also known as Churg-Strauss syndrome (CSS), is a rare autoimmune disease with an estimated incidence of approximately 0.11 to 2.66 new cases per 1 million people per year and an overall prevalence of 10. Read More

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http://dx.doi.org/10.1016/j.carpath.2018.12.004DOI Listing
December 2018
1 Read

Response to the letter to the editor by Fakoya et al.

Cardiovasc Pathol 2018 Dec 21;39:68-69. Epub 2018 Dec 21.

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http://dx.doi.org/10.1016/j.carpath.2018.12.002DOI Listing
December 2018

Two autopsy cases of rupture of the aorta by fistula formation after thoracic endovascular aortic repair and open stent-grafting on aortic arch aneurysm.

Cardiovasc Pathol 2018 Dec 21;39:61-66. Epub 2018 Dec 21.

Tokyo Medical Examiner's Office, Tokyo 112-0012, Japan; Department of Legal Medicine, Kanazawa Medical University, Ishikawa 920-0293, Japan.

The mortality rate of aortic aneurysm/dissection is low in Japan. Two surgical procedures, the thoracic endovascular aortic repair (TEVAR) and the open stent-grafting have contributed much in survival of such aneurysmal patients. We encountered with two autopsy cases of death by aortic rupture with fistula formation after these procedures. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10548807183031
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http://dx.doi.org/10.1016/j.carpath.2018.12.007DOI Listing
December 2018
6 Reads

Evaluation of cellular ingrowth within porcine extracellular matrix scaffolding in congenital heart disease surgery.

Cardiovasc Pathol 2018 Dec 21;39:54-60. Epub 2018 Dec 21.

Department of Pathology and Microbiology, University of Nebraska Medical Center, 983135 Nebraska Medical Center, Omaha, NE,68198-3135. Electronic address:

The search for an ideal material for cardiac tissue repair has led to utilization of porcine small intestinal submucosa extracellular matrix (CorMatrix). Here, we examine the histologic features of CorMatrix and the associated cellular growth at a variety of time intervals. Tissues with CorMatrix from ten patients (4 male, 6 female) with ages ranging from 2 weeks to 2 years, and implant duration ranging from 1 week to 2 years were included in this study. Read More

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http://dx.doi.org/10.1016/j.carpath.2018.12.003DOI Listing
December 2018
1 Read

Metakaryotic cells linked to pediatric pulmonary vein stenosis.

Cardiovasc Pathol 2018 Dec 21;39:51-53. Epub 2018 Dec 21.

Laboratory in Metakaryotic Biology (LIMB), Department of Biological Engineering, Massachusetts Institute of Technology.

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http://dx.doi.org/10.1016/j.carpath.2018.12.005DOI Listing
December 2018
2 Reads

Congenital abnormalities of the aortic arch: revisiting the 1964 Stewart classification.

Cardiovasc Pathol 2018 Dec 6;39:38-50. Epub 2018 Dec 6.

Department of Obstetrics & Gynecology, Howard University, College of Medicine, Washington, DC 20060, USA. Electronic address:

The traditional classification of congenital aortic arch abnormalities was described by James Stewart and colleagues in 1964. Since that time, advances in diagnostic imaging technology have led to better delineation of the vasculature anatomy and the identification of previously unrecognized and unclassified anomalies. In this manuscript, we review the existing literature and propose a series of modifications to the original Stewart classification of congenital aortic arch abnormalities to incorporate this new knowledge. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10548807183018
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http://dx.doi.org/10.1016/j.carpath.2018.11.004DOI Listing
December 2018
5 Reads

Increased mesenchymal podoplanin expression is associated with calcification in aortic valves.

Cardiovasc Pathol 2018 Dec 7;39:30-37. Epub 2018 Dec 7.

School of Pharmacy, Faculty of Health Sciences, University of Eastern Finland, Kuopio, Finland. Electronic address:

Background And Aim Of The Study: Calcific aortic valve disease (CAVD) is a progressive disease starting from mild valvular sclerosis and progressing to severe aortic stenosis (AS) with calcified valves. The origin of the calcification is proposed to be mesenchymal cells which have differentiated towards an osteoblastic phenotype. Podoplanin is a glycoprotein expressed in the endothelium of lymphatic vessels and in osteoblasts and osteocytes, mesenchymal cells, as well as in many carcinomas and aortic atherosclerotic lesions. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10548807183026
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http://dx.doi.org/10.1016/j.carpath.2018.11.006DOI Listing
December 2018
6 Reads

A novel alignment procedure to assess calcified coronary plaques in histopathology, post-mortem computed tomography angiography and optical coherence tomography.

Cardiovasc Pathol 2018 Dec 7;39:25-29. Epub 2018 Dec 7.

Department of Medical Research, Odense University Hospital Svendborg, Valdemarsgade, 53, Svendborg, Denmark.

Purpose: Improve mapping and registration of longitudinal view on histopathology vessels in a three-dimensional alignment procedure for postmortem quantitative coronary plaque analyses. This new procedure is applied and results shown using calcified coronary plaque analyses within post-mortem computed tomography angiography (PMCTA), optical coherence tomography (OCT) and the gold standard of histopathology.

Results: In total, 338 annotated histopathology images were included, 166 PMCTA transversal images and 285 OCT images were aligned in the comparison. Read More

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http://dx.doi.org/10.1016/j.carpath.2018.11.005DOI Listing
December 2018
3 Reads

Lysosomal storage disorders affecting the heart: a review.

Cardiovasc Pathol 2018 Dec 1;39:12-24. Epub 2018 Dec 1.

Department of Pathology and Laboratory Medicine, Ottawa Hospital and Faculty of Medicine, University of Ottawa, 451 Smyth Road, Ottawa, Ontario, K1H 8M5, Canada.

Lysosomal storage disorders (LSD) comprise a group of diseases caused by a deficiency of lysosomal enzymes, membrane transporters or other proteins involved in lysosomal biology. Lysosomal storage disorders result from an accumulation of specific substrates, due to the inability to break them down. The diseases are classified according to the type of material that is accumulated; for example, lipid storage disorders, mucopolysaccharidoses and glycoproteinoses. Read More

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http://dx.doi.org/10.1016/j.carpath.2018.11.002DOI Listing
December 2018
3 Reads

Primary angiosarcoma of the femoral artery in patient with kidney and liver polycystosis and multiple arterial aneurysms: report of the case and review of the literature.

Cardiovasc Pathol 2018 Nov 30;39:8-11. Epub 2018 Nov 30.

Department of Pathology and Molecular Medicine, 2nd Faculty of Medicine, Charles University and Motol University Hospital, V Uvalu 84, Prague, 5, 150 06, Czech Republic.

The association between kidney and liver polycystosis and arterial aneurysms is well documented. However, it remains unclear whether these patients are at increased risk of malignant transformation. In this article, we describe a case of a primary angiosarcoma of the femoral artery with metastatic spread into the lungs and hilar lymph node arising in a 74-year-old man with kidney and liver polycystosis and multiple arterial aneurysms. Read More

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http://dx.doi.org/10.1016/j.carpath.2018.11.001DOI Listing
November 2018
1 Read

A cardiac mass beyond symptomatic palpitations.

Cardiovasc Pathol 2018 Oct 29;39:1-4. Epub 2018 Oct 29.

Cardiothoracic Surgery Department, Hospital de Santa Cruz, Centro Hospitalar de Lisboa Ocidental Carnaxide, Portugal.

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http://dx.doi.org/10.1016/j.carpath.2018.10.007DOI Listing
October 2018
1 Read

A case of Brucella aortitis associated with development of thoracic aortic aneurysm and aortobronchial fistula.

Cardiovasc Pathol 2018 Nov 7;39:5-7. Epub 2018 Nov 7.

Department of Pathology and Laboratory Medicine, The University of Texas Health Science Center at Houston/Memorial Hermann Hospital-Texas Medical Center, 6431 Fannin St, Houston, TX 77030, USA. Electronic address:

Objectives: The purpose of this case report is to document the occurrence of granulomatous aortitis complicated by formation of a saccular aneurysm and aortobronchial fistula due to Brucella infection.

Methods: A 65-year-old man with a history of feral swine hunting presented with hemoptysis and was found to have a saccular thoracic aortic aneurysm and associated aortobronchial fistula. The aneurysm underwent operative repair with closure of the aortobronchial fistula. Read More

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http://dx.doi.org/10.1016/j.carpath.2018.10.011DOI Listing
November 2018
7 Reads

CO-related vasoconstriction superimposed on ischemic medullary brain autonomic nuclei may contribute to sudden death.

Cardiovasc Pathol 2019 Jan - Feb;38:42-45. Epub 2018 Oct 26.

"Lino Rossi" Research Center, Department of Biomedical, Surgical and Dental Sciences, University of Milan, 20122 Milan, Italy. Electronic address:

Introduction: In 2015, a multinational randomized controlled phase IV clinical trial of adaptive servoventilation for the management of heart failure with central sleep apnea was halted in progress because more patients in the study group were dying than in the control group. One year later, another large clinical trial reported results on the effectiveness of continuous positive airway pressure (CPAP) in preventing sudden death and other cardiovascular events such as heart attack and stroke in patients with preexisting vascular disease as well as obstructive sleep apnea.

Background: Sudden unexpected death has been associated with many types of small and nonmalignant medullary brain lesions, like demyelination plaques - largely asymptomatic until they caused sudden death. Read More

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http://dx.doi.org/10.1016/j.carpath.2018.10.009DOI Listing
October 2018
10 Reads
2.340 Impact Factor

Vascular malformation in a bicuspid aortic valve.

Cardiovasc Pathol 2019 Jan - Feb;38:39-41. Epub 2018 Oct 24.

Department of Pathology, Assistance Publique-Hôpitaux de Paris, Hôpital Européen Georges Pompidou, 20 rue Leblanc, 75015-, Paris, France.

We report here a case of capillary vascular malformation developed in a bicuspid aortic valve incidentally detected during valve replacement in a 67-year-old male patient. The International Society for the Study of Vascular Anomalies (ISSVA) classification was used to classify this vascular lesion instead of using the term hemangioma. The differential diagnosis and the literature are reviewed. Read More

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https://www.cardiovascularpathology.com/article/S1054-8807(1
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https://linkinghub.elsevier.com/retrieve/pii/S10548807183029
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http://dx.doi.org/10.1016/j.carpath.2018.10.006DOI Listing
October 2018
9 Reads

Morphology and mechanisms of a novel absorbable polymeric conduit in the pulmonary circulation of sheep.

Cardiovasc Pathol 2019 Jan - Feb;38:31-38. Epub 2018 Oct 25.

Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, 75 Francis Street, Boston, MA, USA. Electronic address:

Background: Right ventricular outflow tract (RVOT) conduits used in children with congenital heart disease often degenerate rapidly or develop other complications, and they do not grow with the patient. This leads to multiple surgeries until adult-sized conduits can be implanted. We report experimental in vivo experience with an entirely synthetic absorbable graft, designed to be replaced by tissue in-vivo by host cells, in a process termed Endogenous Tissue Restoration (ETR), and to grow commensurate with somatic growth. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10548807183023
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http://dx.doi.org/10.1016/j.carpath.2018.10.008DOI Listing
October 2018
8 Reads

Expression of tenascin C in cardiovascular lesions of Kawasaki disease.

Cardiovasc Pathol 2019 Jan - Feb;38:25-30. Epub 2018 Oct 24.

Department of Surgical Pathology, Toho University Ohashi Medical Center, Tokyo, Japan.

Background/objective: To examine tenascin C (TN-C) expression in coronary artery lesions (CALs) and myocardial lesions (MLs) in Kawasaki disease (KD).

Methods And Results: Twenty-five KD autopsy cases (post-KD-onset range of 6 days to 17 years) were examined in this study. Time-course analysis based on the disease day was performed of the histological findings for the CALs and MLs, as well as the localization and intensity of expression of TN-C. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10548807183010
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http://dx.doi.org/10.1016/j.carpath.2018.10.005DOI Listing
October 2018
12 Reads

Endomyocardial fibrosis and myocardial infarction leading to diastolic and systolic dysfunction requiring transplantation.

Cardiovasc Pathol 2019 Jan - Feb;38:21-24. Epub 2018 Oct 31.

Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padova, Padova, Italy. Electronic address:

Endomyocardial fibrosis (EMF) is an endemic disease in tropical areas, characterized by restrictive physiology due to endocardial fibrous thickening of the ventricular chambers. We report the case of a 25-year-old man of African origin who presented with end-stage heart failure due to both diastolic and systolic dysfunction and extensive endocavitary thrombosis as proven by echocardiography and cardiac magnetic resonance. EMF diagnosis was confirmed by endomyocardial biopsy and the patient had eventually cardiac transplantation. Read More

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http://dx.doi.org/10.1016/j.carpath.2018.10.010DOI Listing
October 2018
2 Reads

Pathological correlates of brain arterial calcifications.

Cardiovasc Pathol 2019 Jan - Feb;38:7-13. Epub 2018 Oct 12.

Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY. Electronic address:

Background: In clinical practice, calcifications seen on computed tomographic studies within the large brain arteries are often referred to as a surrogate marker for cholesterol-mediated atherosclerosis. However, limited data exist to support the association between calcification and atherosclerosis. In this study, we examined if intracranial arterial calcifications were associated with cholesterol-mediated intracranial large artery atherosclerosis (ILAA) within the arteries of the circle of Willis in an autopsy-based sample. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10548807183020
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http://dx.doi.org/10.1016/j.carpath.2018.09.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6294705PMC
October 2018
18 Reads

Thrombus on the inflow cannula of the HeartWare HVAD: an update.

Cardiovasc Pathol 2019 Jan - Feb;38:14-20. Epub 2018 Sep 15.

Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115. Electronic address:

Background: The HeartWare HVAD (Medtronic, Minneapolis, MN) is a continuous-flow left ventricular assist device (LVAD) approved by the FDA in 2012 as a bridge to transplant in patients with end-stage left ventricular heart failure. The current inflow cannula has a smooth outer surface near the inflow edge and a sintered collar of titanium microspheres near the pump. A previous case series of HVAD patients bridged to transplant revealed thrombus on the outer surface of the inflow cannula in 8 of 8 patients, predominantly at the smooth-sintered interface, that was associated with a clinical stroke rate of 12. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10548807183015
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http://dx.doi.org/10.1016/j.carpath.2018.09.002DOI Listing
September 2018
19 Reads

Renal cystic disease in the Fbn1 Marfan mouse is associated with enhanced aortic aneurysm formation.

Cardiovasc Pathol 2019 Jan - Feb;38:1-6. Epub 2018 Oct 16.

Department of Medical Biochemistry, Amsterdam Cardiovascular Sciences, Amsterdam UMC, Univ of Amsterdam, Meibergdreef 9, Amsterdam, the Netherlands. Electronic address:

Marfan syndrome (MFS) is a connective tissue disorder caused by mutations in the fibrillin-1 gene (FBN1), resulting in aortic aneurysm formation and dissections. Interestingly, variable aortopathy is observed even within MFS families with the same mutation. Thus, additional risk factors determine disease severity. Read More

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http://dx.doi.org/10.1016/j.carpath.2018.10.002DOI Listing
October 2018
1 Read

A case of biopsy-proven eosinophilic myocarditis related to tetanus toxoid immunization.

Cardiovasc Pathol 2018 Nov - Dec;37:54-57. Epub 2018 Oct 9.

Department of Clinical Research, Chiba Tokushukai Hospital, Chiba, Japan.

Vaccine-associated myocarditis is an extremely rare, yet potentially lethal disease, which requires early diagnosis and prompt treatment. However, its pathogenesis remains elusive. We report the first case of biopsy-proven eosinophilic myocarditis related to tetanus toxoid immunization, with unique histopathologic findings, characterized by perivascular eosinophilic infiltrates with myocyte necrosis and abundant interstitial lymphocytic infiltrates with myocyte necrosis, separately. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10548807183023
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http://dx.doi.org/10.1016/j.carpath.2018.10.003DOI Listing
January 2019
13 Reads

Coronary artery myointimal dysplasia in patients with pheochromocytoma-possible causal relationship: pathophysiology and clinical implication with reference to Takotsubo cardiomyopathy and spontaneous coronary dissection.

Cardiovasc Pathol 2018 Nov - Dec;37:45-53. Epub 2018 Oct 11.

Department of Clinical Pathology, Tuen Mun Hospital, New Territory, Hong Kong.

Myocardial damage in catecholamine cardiomyopathy, characterized by patchy myocyte necrosis commonly with contraction band appearances, interstitial fibrosis, and varying degrees of inflammatory infiltrates, has been well documented. However, coronary vascular pathology has not been recognized. Autopsy of a 43-year-old housewife who died of acute apical anteroseptal myocardial infarction revealed the incidental finding of a left adrenal pheochromocytoma. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10548807183022
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http://dx.doi.org/10.1016/j.carpath.2018.10.001DOI Listing
January 2019
8 Reads

Infrasound induces coronary perivascular fibrosis in rats.

Cardiovasc Pathol 2018 Nov - Dec;37:39-44. Epub 2018 Oct 9.

Center for Interdisciplinary Research Egas Moniz (CIIEM), Health Sciences Institute, Monte de Caparica, Portugal. Electronic address:

Background: Chronic exposure to industrial noise is known to affect biological systems, namely, by inducing fibrosis in the absence of inflammatory cells. In rat hearts exposed to this environmental hazard, we have previously found myocardial and perivascular fibrosis. The acoustic spectrum of industrial environments is particularly rich in high-intensity infrasound (<20 Hz), whose effects on the heart are unknown. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10548807183028
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http://dx.doi.org/10.1016/j.carpath.2018.10.004DOI Listing
January 2019
12 Reads

Potential cardiac consequences of thrombocytopenia and thrombocytosis.

Cardiovasc Pathol 2018 Nov - Dec;37:34-38. Epub 2018 Aug 17.

Baylor Scott & White Heart and Vascular Institute, Baylor University Medical Center, Baylor Scott & White Health, Dallas, TX; Department of Pathology, Baylor University Medical Center, Baylor Scott & White Health, Dallas, TX; Department of Internal Medicine (Division of Cardiology), Baylor University Medical Center, Baylor Scott & White Health, Dallas, TX.

This report illustrates the heart in three patients with cardiac hemorrhages associated with extreme thrombocytopenia, and the hearts in three patients with rocks speculated to result at least in part from organization of thrombi possibly related to thrombocytosis in one or more cardiac chambers. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10548807183022
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http://dx.doi.org/10.1016/j.carpath.2018.08.002DOI Listing
January 2019
17 Reads

Phenotypic variations in carriers of predicted protein-truncating genetic variants in MYBPC3: an autopsy-based case series.

Cardiovasc Pathol 2018 Nov - Dec;37:30-33. Epub 2018 Sep 13.

Molecular Genetics Laboratory, New York City Office of Chief Medical Examiner, New York City, United States. Electronic address:

Our aim is to characterize predicted protein-truncating variants (PTVs) in MYBPC3, the gene most commonly associated with hypertrophic cardiomyopathy (HCM), found in a series of autopsied HCM cases after sudden unexpected cardiac death. All cases underwent death scene investigation, gross and microscopic autopsies, toxicological testing, a review of medical records, and a molecular analysis of 95 cardiac genes. We found four pathogenic PTVs in MYBPC3 among male decedents. Read More

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http://dx.doi.org/10.1016/j.carpath.2018.09.001DOI Listing
January 2019
5 Reads

Myocardial rupture after small acute myocardial infarction in the absence of coronary artery disease.

Cardiovasc Pathol 2018 Nov - Dec;37:26-29. Epub 2018 Aug 25.

Division of Cardiovascular Disease, University of Alabama at Birmingham. Electronic address:

A 73-year-old woman with a past medical history of hypertension suffered a cardiac arrest. After successful resuscitation, she was hypotensive and tachycardic and the ECG showed ST elevation in the inferior and lateral precordial leads. Coronary angiography did not show evidence of obstructive coronary artery disease. Read More

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http://dx.doi.org/10.1016/j.carpath.2018.08.004DOI Listing
January 2019
5 Reads

miR-143 and miR-145 promote hypoxia-induced proliferation and migration of pulmonary arterial smooth muscle cells through regulating ABCA1 expression.

Cardiovasc Pathol 2018 Nov - Dec;37:15-25. Epub 2018 Aug 23.

Department of Internal Medicine-Cardiovascular, Huaihe Hospital of Henan University. Electronic address:

Background: Excessive proliferation and migration of pulmonary artery smooth muscle cells (PASMCs) play an important role in the occurrence and development of pulmonary arterial hypertension (PAH). miR-143/145 was reported to be up-regulated in the animal models and PAH patients, and deletion of miR-143/145 cluster prevented the development of hypoxia-induced pulmonary hypertension, but its underlying mechanism has not been elucidated.

Methods: qRT-PCR and Western blot were performed to detect the expressions of miR-143/145 and ATP-binding cassette transporter A1 (ABCA1) in PAH patients and PASMCs under hypoxic conditions. Read More

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http://dx.doi.org/10.1016/j.carpath.2018.08.003DOI Listing
January 2019
2 Reads
2.340 Impact Factor

Histone demethylase JARID1B regulates proliferation and migration of pulmonary arterial smooth muscle cells in mice with chronic hypoxia-induced pulmonary hypertension via nuclear factor-kappa B (NFkB).

Cardiovasc Pathol 2018 Nov - Dec;37:8-14. Epub 2018 Aug 3.

Cardiovascular Department, the First Affiliated Hospital of Harbin Medical University, Harbin, China. Electronic address:

Chronic hypoxia-induced pulmonary hypertension (PH) is a disorder that is characterized by increased pulmonary arterial pressure resulting from lung diseases or shortage of oxygen in the body. Excess proliferation of pulmonary vascular cells such as pulmonary artery endothelial cells (PAECs) and pulmonary artery smooth muscle cells (PASMCs) plays a critical role in the pathogenesis of PH. Recent evidence indicates that, in addition to genetic predisposition and environmental factors, epigenetic mechanisms play a pivotal role in etiology of PH. Read More

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http://dx.doi.org/10.1016/j.carpath.2018.07.004DOI Listing
January 2019
2 Reads

Tuberculous myocarditis on autopsy: a rare underdiagnosed entity.

Cardiovasc Pathol 2018 Nov - Dec;37:5-7. Epub 2018 Aug 10.

Dept. of Pathology, PGIMS, Rohtak, Haryana, India. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S10548807183020
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http://dx.doi.org/10.1016/j.carpath.2018.08.001DOI Listing
August 2018
8 Reads

Three-dimensional histologic reconstruction of remnant functional accessory atrioventricular myocardial connections in a case of Wolff-Parkinson-White syndrome.

Cardiovasc Pathol 2018 Nov - Dec;37:1-4. Epub 2018 Jul 27.

Department of Pathology, National Cerebral and Cardiovascular Center, Osaka, Japan.

Myocardial bundles working as accessory pathways in Wolff-Parkinson-White (WPW) syndrome are generally tiny tissues, so elucidating the culprit histology of atrioventricular (AV) myocardial connections requires careful serial sectioning of the AV junction. We performed a postmortem examination of accessory AV myocardial connections in an 84-year-old man who died from pneumonia 20 years after surgical cryoablation for WPW syndrome. Three-dimensional reconstruction images of serial histologic sections revealed accessory AV connections between the atrial and ventricular myocardium in the vicinity of the cryoablation scar. Read More

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http://dx.doi.org/10.1016/j.carpath.2018.07.003DOI Listing
January 2019
3 Reads

A novel mutation of dystrophin in a Becker muscular dystrophy family with severe cardiac involvement: from genetics to clinicopathology.

Cardiovasc Pathol 2018 Sep - Oct;36:64-70. Epub 2018 Jul 26.

State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College. Electronic address:

Background: Dystrophin gene defects are the pathogenic molecular basis of Becker muscular dystrophy (BMD), characterised by skeletal myopathy and cardiomyopathy. Because of the broad phenotype spectrum, it was difficult to use the traditional diagnostic method to achieve an early accurate diagnosis of BMD-associated cardiomyopathy.

Methods: We applied an in-house gene panel testing and a gene-filtering strategy to investigate the genetic defect in a four-generation family with 73 members. Read More

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http://dx.doi.org/10.1016/j.carpath.2018.07.002DOI Listing
December 2018
9 Reads

In memoriam Hugh H. McAllister, Jr., M.D.

Cardiovasc Pathol 2018 Sep - Oct;36:i-ii. Epub 2018 Jul 22.

McGovern Medical School of The University of Texas Health Science Center at Houston (UT Health) Houston, Texas 77005. Electronic address:

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http://dx.doi.org/10.1016/j.carpath.2018.07.001DOI Listing
July 2018
2 Reads

CD39 and CD73 in the aortic valve-biochemical and immunohistochemical analysis in valve cell populations and its changes in valve mineralization.

Cardiovasc Pathol 2018 Sep - Oct;36:53-63. Epub 2018 Jun 7.

Department of Biochemistry, Medical University of Gdansk, 80-211 Gdansk, Debinki 1, Poland. Electronic address:

Background: The calcific aortic valve disease (CAVD) is a common heart pathology that involves inflammation, fibrosis, and calcification of aortic valve leaflets. All these processes could be affected by changes in the extracellular purinergic signaling that depend on the activity of ectonucleotidases, mainly ectonucleoside triphosphate diphosphohydrolase 1 (CD39, eNTPD1) and ecto-5'nucleotidase (CD73, e5NT).

Objective And Methods: We investigated the localization of CD39 and CD73 proteins in human noncalcified and calcified aortic valves using immunohistochemistry together with analysis of NTPDases and e5NT activities in aortic valve homogenates by analysis of substrate into product conversion by high-performance liquid chromatography. Read More

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http://dx.doi.org/10.1016/j.carpath.2018.05.008DOI Listing
December 2018
7 Reads

Method for preclinical pathology evaluation and analysis of cardiovascular implantable electronic device implant sites.

Cardiovasc Pathol 2018 Sep - Oct;36:44-52. Epub 2018 May 18.

Department of Biomedical Engineering, Texas A&M University, College Station, TX, USA; Department of Veterinary Pathobiology, Texas A&M University, College Station, TX, USA. Electronic address:

Cardiovascular implantable electronic devices (CIEDs) typically incorporate leads that directly contact the endocardium. Post-explant pathology evaluation of formalin-fixed CIED lead implant sites and downstream organs (i.e. Read More

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http://dx.doi.org/10.1016/j.carpath.2018.05.002DOI Listing
December 2018
5 Reads

Consensus documents - past, present, and future.

Cardiovasc Pathol 2018 Sep - Oct;36:42-43. Epub 2018 Jun 22.

Departments of Pathology and Laboratory Medicine, Providence Health Care / University of British Columbia, 1081 Burrard Street, Vancouver, British Columbia, V6Z 1Y6, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.carpath.2018.06.003DOI Listing
June 2018
2 Reads

Splenectomy had no significant impact on lipid metabolism and atherogenesis in Apoe deficient mice fed on a severe atherogenic diet.

Cardiovasc Pathol 2018 Sep - Oct;36:35-41. Epub 2018 Jun 23.

Department of Cardiology, Institute of Cardiovascular Diseases, First Affiliated Hospital of Dalian Medical University, No.193, Lianhe Road, Xigang District, Dalian 116011, China. Electronic address:

Background: For a long time, our major understanding of the spleen is to function as a blood filter for the removal of aged erythrocytes and circulating microorganisms. Splenectomy, therefore, has been widely performed in case of trauma and a variety of hematologic disorders. Although some studies have indicated an increased rate of developing hyperlipidemia and atherosclerotic cardiovascular diseases in splenectomized patients, our recognition of the splenic regulation on lipid metabolism and atherogenesis is still lacking. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10548807183015
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http://dx.doi.org/10.1016/j.carpath.2018.06.002DOI Listing
December 2018
18 Reads

Candida parapsilosis endocarditis in an intravenous drug abuser: an autopsy report.

Cardiovasc Pathol 2018 Sep - Oct;36:30-34. Epub 2018 Jun 7.

Department of Cardiology, Post Graduate Institute of Medical Sciences & Research, [PGIMER], Sector-12, Chandigarh, 160012, India.

Candida parapsilosis is a rare cause of endocarditis, which is seen to affect the native valves in patients who are known intravenous drug abusers or following contamination during surgery for prosthetic valves. We discuss a unique constellation of autopsy findings in a 35-year-old chronic opium abuser who presented with left-sided weakness followed by low-grade fever. He was diagnosed to have C. Read More

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http://dx.doi.org/10.1016/j.carpath.2018.05.005DOI Listing
December 2018
22 Reads

Mesothelial/monocytic incidental cardiac excrescences (MICE): report of a case and review of literature with focus on pathogenesis.

Cardiovasc Pathol 2018 Sep - Oct;36:25-29. Epub 2018 Jun 10.

Pathology Unit, Department of Pathology and Diagnostic, University and Hospital Trust of Verona, Verona, Italy.

Mesothelial/monocytic incidental cardiac excrescence (MICE) is a benign lesion composed of histiocytes and mesothelial cells, usually found during cardiac surgery. To date, no more than 50 cases are reported in literature, and pathogenesis is still unclear even if different theories have been proposed. Here we report a case of MICE encountered during aortic valve replacement with typical histological features and extensive immunohistochemical investigation. Read More

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http://dx.doi.org/10.1016/j.carpath.2018.06.001DOI Listing
December 2018
6 Reads

Intramural capillary hemangioma of gallbladder artery: age-related or treatment-induced change?

Cardiovasc Pathol 2018 Sep - Oct;36:22-24. Epub 2018 Jun 7.

APHP GHU Avicenne; Universite Paris Nord Sorbonne Cite, Bobigny, France. Electronic address:

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http://dx.doi.org/10.1016/j.carpath.2018.05.006DOI Listing
June 2018
4 Reads

Pathological evidence of adrenergic cardiac denervation in a patient with congestive heart failure.

Cardiovasc Pathol 2018 Sep - Oct;36:20-21. Epub 2018 Jun 5.

Unit of Geriatrics, Policlinico Universitario Campus Bio-Medico di Roma, Via Álvaro del Portillo 21, 00128, Rome, Italy.

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http://dx.doi.org/10.1016/j.carpath.2018.05.007DOI Listing
June 2018
14 Reads

Coronary pathology of inherited generalized arterial calcification of infancy: a case report.

Cardiovasc Pathol 2018 Sep - Oct;36:15-19. Epub 2018 May 18.

CVPath Institute, Inc., Gaithersburg, MD, USA. Electronic address:

Generalized arterial calcification of infancy (GACI), or idiopathic infantile arterial calcification, is a rare autosomal-recessive disease recognized aAs an inherited disorder characterized by severe pathologic calcification of large- and medium-sized arteries accompanied by smooth muscle cell (SMC) hyperplasia leading to vascular obstruction [1]. The prognosis is extremely poor, with 85% of affected infants dying within the first 6 months of life. Loss-of-function mutations in the ectonucleotide pyrophosphatase phosphodiesterase 1 (ENPP1) gene is recognized as the main defect associated with GACI [1]. Read More

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http://dx.doi.org/10.1016/j.carpath.2018.05.001DOI Listing
December 2018
24 Reads

Aortic valve replacement for aortic regurgitation associated with osteogenesis imperfecta.

Cardiovasc Pathol 2018 Sep - Oct;36:11-14. Epub 2018 May 24.

The Department of Cardiovascular Surgery, Nihon University School of Medicine, 30-1 Oyaguchi-kamimachi Itabashi-ku, Tokyo 173-8610, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.carpath.2018.05.004DOI Listing
May 2018
3 Reads

Achromobacter endocarditis in native cardiac valves - an autopsy case report and review of the literature.

Cardiovasc Pathol 2018 Sep - Oct;36:6-10. Epub 2018 May 22.

Department of Pathology, State University of New York Downstate Medical Center, Brooklyn, NY 11203, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S10548807173036
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http://dx.doi.org/10.1016/j.carpath.2018.05.003DOI Listing
May 2018
6 Reads