1,713,276 results match your criteria Cardiovascular Pathology[Journal]


The Effect of Vitamin D Supplementation on Prostate Cancer: A Systematic Review and Meta-Analysis of Clinical Trials.

Horm Metab Res 2018 Dec 6. Epub 2018 Dec 6.

Nutrition and Food Security Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.

Vitamin D has received attention for its potential to disrupt cancer processes. However, its effect in the treatment of prostate cancer is controversial. This study aimed to assess the effect of vitamin D supplementation on patients with prostate cancer. Read More

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December 2018
3 Reads

Impact of Hybrid Therapy Comprising Peritoneal Dialysis and Hemodialysis on Acute Cardiovascular Events.

Blood Purif 2018 Dec 6:1-7. Epub 2018 Dec 6.

Background: The impact of hybrid therapy comprising peritoneal dialysis (PD) and hemodialysis on cardiovascular events in PD patients remains unclear.

Objective: We aimed to evaluate the effect of hybrid therapy on cardiovascular events.

Methods: A total of 93 PD patients undergoing hybrid therapy for ≥3 years were divided into 2 groups according to left ventricular ejection fraction (LVEF): lower ejection fraction (LEF [n = 29], LVEF < 60%) and normal ejection fraction (NEF [n = 64], LVEF ≥60%). Read More

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December 2018
2 Reads

Developing a Process for Returning Medically Actionable Genomic Variants to Latino Patients in a Federally Qualified Health Center.

Public Health Genomics 2018 Dec 6:1-8. Epub 2018 Dec 6.

Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA.

Aim: To develop a process for returning medically actionable genomic variants to Latino patients receiving care in a Federally Qualified Health Center.

Methods: Prior to recruitment, researchers met with primary care providers to (1) orient clinicians to the project, (2) establish a process for returning actionable and nonactionable results to participants and providers through the electronic health record, and (3) develop a process for offering clinical decision support for follow-up education and care. A Community Advisory Board was engaged to provide input on recruitment strategies and materials for conveying results to participants. Read More

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December 2018
3 Reads

The appropriateness of coronary investigation in myocardial injury and type 2 myocardial infarction (ACT-2): A randomized trial design.

Am Heart J 2018 Oct 25;208:11-20. Epub 2018 Oct 25.

Department of Cardiology, Flinders Medical Centre, Adelaide, Australia; College of Medicine and Public Health, Flinders University of South Australia, Adelaide, Australia. Electronic address:

Background: Elevated troponin level findings among patients presenting with suspected acute coronary syndrome (ACS) or another intercurrent illness undeniably identifies patients at increased risk of mortality. Whilst enhancing our capacity to discriminate risk, the use of high-sensitivity troponin assays frequently identifies patients with myocardial injury (i.e. Read More

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October 2018
2 Reads

Longer schooling but not better off? A quasi-experimental study of the effect of compulsory schooling on biomarkers in France.

Soc Sci Med 2018 Nov 23;220:379-386. Epub 2018 Nov 23.

Department of Social and Behavioral Sciences, Harvard T H Chan School of Public Health, 677 Huntington Ave, Boston, MA, 02115, USA; CUNY Graduate School of Public Health and Health Policy, 205 East 42nd Street, New York, NY, 10017, USA.

Less schooling is associated with increased biological risks for chronic disease, but whether increasing years of schooling through policy interventions reduces these risks remains unclear. We examine the effect of a major education reform introduced in 1959 that raised the minimum school leaving age from 14 to 16 years in France, offering a unique natural experiment. We assess the causal impact of increased schooling duration on 16 biomarkers of cardiovascular, metabolic, organ and immune function in a large cohort of men and women born around 1953. Read More

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November 2018
6 Reads

Systemic thrombolysis in haemodynamically unstable pulmonary embolism: The earlier the better?

Thromb Res 2018 Nov 29;173:117-123. Epub 2018 Nov 29.

Department of Cardiology, Santa Maria della Misericordia Hospital, Rovigo, Italy. Electronic address:

Introduction: The temporal window for the administration of systemic thrombolysis (ST) in acute pulmonary embolism (PE) has not yet been clarified. We assessed the relationship between short-term cardiovascular (CV) mortality and time of ST administration.

Material And Methods: Among 394 consecutive patients admitted between January 2010 and June 2017 with a confirmed PE, we retrospectively review the clinical and instrumental data of those labelled as high-risk PE (n = 76, 41 males, mean aged 64. Read More

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November 2018
4 Reads

Gastric wall fat halo sign in patients without intestinal disease.

Clin Imaging 2018 Nov 30;54:31-36. Epub 2018 Nov 30.

Trabzon Kanuni Education and Research Hospital, Department of Radiology, 61080 Trabzon, Turkey.

Purpose: To investigate the relationship between gastric wall fat halo sign and visceral obesity with potentially associated diseases.

Materials And Methods: Between September 2015 and April 2017, 90 patients with gastric wall fat halo signs and 130 controls were prospectively evaluated. Patient height, weight, body mass index (BMI), sex, age, subcutaneous fat area (SFA), visceral fat area (VFA), total fat area (TFA), percentage of visceral fat (VF%) and the presence of colic or ileal fat halo signs, hepatic steatosis and aortic calcified plaques were recorded for the two groups. Read More

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November 2018
4 Reads

First ethnobotanical inventory and phytochemical analysis of plant species used by indigenous people living in the Maromizaha forest, Madagascar.

J Ethnopharmacol 2018 Dec 3. Epub 2018 Dec 3.

Department of Agriculture, Forestry and Food Science, University of Torino, Torino, Italy.

Ethnopharmacological Relevance: Characterized by one of the highest rates of endemism and biodiversity in the world, Madagascar provides a wide variety of medicinal plants, that could represent a potential source of new drugs. The main aim of this study was to investigate the potential medicinal properties of the plant species used by indigenous people in Maromizaha forest and to provide the first ethnobotanical inventory of the area.

Materials And Methods: Data were collected through open semi-structured interviews with local informants, the reported plants were collected and identified to create a specimen herbarium. Read More

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December 2018
6 Reads

Left Atrial Appendage Closure Device Implantation in Patients with Prior Intracranial Hemorrhage.

Heart Rhythm 2018 Nov 19. Epub 2018 Nov 19.

Section of Cardiac Pacing and Electrophysiology, Heart and Vascular Institute, Cleveland Clinic Foundation, Cleveland, OH. Electronic address:

Background: The Watchman™ device (Boston Scientific, MN), used for left atrial appendage closure (LAAC) was approved for stroke prevention in patients with atrial fibrillation (AF) and an appropriate rationale to avoid long-term oral anticoagulation. Patients with AF and prior intracranial hemorrhage (ICH) were excluded from clinical trials due to perceived risks of peri-operative anticoagulation.

Objective: We studied the efficacy and safety of LAAC using Watchman™ in patients with AF and prior ICH. Read More

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November 2018

Mechanistic role of the CREB-regulated transcription coactivator 1 in cardiac hypertrophy.

J Mol Cell Cardiol 2018 Dec 3. Epub 2018 Dec 3.

Department of Clinical Pharmacology and Toxicology, Cardiovascular Research Center, University Medical Center Hamburg-Eppendorf, Martinistr. 52, 20246 Hamburg, Germany; DZHK (German Center for Cardiovascular Research), Partner Site Hamburg, Kiel, Lübeck, Germany; Institute of Pharmacy, University of Hamburg, Bundesstr. 45, 20146 Hamburg, Germany. Electronic address:

The sympathetic nervous system is the main stimulator of cardiac function. While acute activation of the β-adrenoceptors exerts positive inotropic and lusitropic effects by increasing cAMP and Ca, chronically enhanced sympathetic tone with changed β-adrenergic signaling leads to alterations of gene expression and remodeling. The CREB-regulated transcription coactivator 1 (CRTC1) is activated by cAMP and Ca. Read More

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December 2018
2 Reads

Sex differences in stress reactivity after intranasal oxytocin in recreational cannabis users.

Pharmacol Biochem Behav 2018 Dec 3. Epub 2018 Dec 3.

New York State Psychiatric Institute, New York, NY, United States of America; Columbia University Medical Center, New York, NY, United States of America.

Cannabis is the most widely used illicit drugs and the changing legal, political and cultural climate will likely increase cannabis use further. One factor that may underlie the transition from recreational use to problematic use is stress. The hormone oxytocin (OXT) modulates stress and may have therapeutic efficacy for substance use disorders, but few studies have examined OXT in cannabis users. Read More

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December 2018
2 Reads

Cardiovascular development and survival require Mef2c function in the myocardial but not the endothelial lineage.

Dev Biol 2018 Dec 3. Epub 2018 Dec 3.

Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA, 94143, USA; Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA, 94143, USA. Electronic address:

MEF2C is a member of the highly conserved MEF2 family of transcription factors and is a key regulator of cardiovascular development. In mice, Mef2c is expressed in the developing heart and vasculature, including the endothelium. Loss of Mef2c function in germline knockout mice leads to early embryonic demise and profound developmental abnormalities in the cardiovascular system. Read More

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December 2018

Peri-Procedural Antithrombotic Management from a Patient Perspective: A Qualitative Analysis.

Am J Med 2018 Dec 3. Epub 2018 Dec 3.

Center for Bioethics and Social Science in Medicine, University of Michigan, Ann Arbor, MI; Frankel Cardiovascular Center, University of Michigan, Ann Arbor, MI. Electronic address:

Background: Peri-procedural antithrombotic medication management is a complex, often confusing process for patients and their providers. Communication difficulties often lead to suboptimal medication management resulting in delayed or cancelled procedures.

Methods: We conducted telephone surveys with patients taking chronic antithrombotic medications who had recently undergone an endoscopy procedure. Read More

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December 2018
3 Reads

Proton leak regulates mitochondrial reactive oxygen species generation in endothelial cell activation and inflammation - A novel concept.

Arch Biochem Biophys 2018 Dec 3. Epub 2018 Dec 3.

Centers for Metabolic Disease Research, Cardiovascular Research, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, 19140, USA. Electronic address:

Mitochondria are capable of detecting cellular insults and orchestrating inflammatory responses. Mitochondrial reactive oxygen species (mtROS) are intermediates that trigger inflammatory signaling cascade in response to our newly proposed conditional DAMP (damage associated molecular patterns). We recently reported that increased proton leak regulates mtROS generation and thereby exert physiological and pathological activation of endothelial cells. Read More

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December 2018
2 Reads
3.017 Impact Factor

Neuronal Polarization Packs a One-Two Punch.

Neuron 2018 Dec;100(5):1007-1009

Oregon Health and Science University, Knight Cardiovascular Institute, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USA. Electronic address:

In this issue of Neuron, Ambrozkiewicz et al. (2018) define a new molecular circuit controlling neuronal polarization and migration through the transcription factor SOX9 to coordinate the production of regulators of both protein synthesis and degradation. Read More

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December 2018

Pharmacological treatment of obesity

Rev Med Inst Mex Seguro Soc 2018 11 30;56(4):395-409. Epub 2018 Nov 30.

Instituto Mexicano del Seguro Social, Hospital de Especialidades “Dr. Bernardo Sepúlveda Gutiérrez”, Unidad de Investigación Médica en Endocrinología Experimental. Ciudad de México, México

More than 70% of the population in Mexico is overweight or obese, affecting mainly people in productive age. Obesity is associated with the development of diseases that increase cardiovascular risk (diabetes mellitus, hypertension or atherogenic dyslipidemia), diseases that limit the quality of life of the patient (osteoarthrosis or sleep apnea) and even with the increase in the incidence of certain types of cancer (breast or colon). It is evident that the decrease of at least 5% of body weight induces improvement in all these factors; however, in some patients it is difficult to achieve this goal only with lifestyle modifications. Read More

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November 2018
1 Read

Intensive versus standard multifactorial cardiovascular risk factor control in screen-detected type 2 diabetes: 5 year and longer-term modelled outcomes of the ADDITION-Leicester study.

Diabetes Metab Res Rev 2018 Dec 6:e3111. Epub 2018 Dec 6.

Leicester Diabetes Centre, University of Leicester, Leicester, UK.

Aims: Diabetes treatment algorithms recommend intensive intervention in those with a shorter duration of disease. Screening provides opportunities for earlier multifactorial cardiovascular risk factor control. Using data from the ADDITION-Leicester study (NCT00318032), we estimated the effects of this approach on modelled risk of diabetes related complications in screen-detected patients. Read More

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December 2018
1 Read

A simple DNAzyme-based fluorescent assay for Klebsiella pneumoniae.

Chembiochem 2018 Dec 6. Epub 2018 Dec 6.

University of California Irvine, Pharmaceutical Sciences, Sue and Bill Gross Stem Cell Research Center, Edwards Lifesciences Center for Advanced Cardiovascular Technology, Biomedical Engineering, 92697, Irvine, UNITED STATES.

Pathogenic bacteria pose a serious public health threat. Rapid and cost effective detection of such bacteria remains a major challenge. Here, we present a DNAzyme-based fluorescent paper sensor for Klebsiella pneumoniae. Read More

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December 2018
2 Reads

Omega-3 fatty acids for the primary and secondary prevention of cardiovascular disease.

Cochrane Database Syst Rev 2018 11 30;11:CD003177. Epub 2018 Nov 30.

Norwich Medical School, University of East Anglia, Norwich Research Park, Norwich, Norfolk, UK, NR4 7TJ.

Background: Researchers have suggested that omega-3 polyunsaturated fatty acids from oily fish (long-chain omega-3 (LCn3), including eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA)), as well as from plants (alpha-linolenic acid (ALA)) benefit cardiovascular health. Guidelines recommend increasing omega-3-rich foods, and sometimes supplementation, but recent trials have not confirmed this.

Objectives: To assess effects of increased intake of fish- and plant-based omega-3 for all-cause mortality, cardiovascular (CVD) events, adiposity and lipids. Read More

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November 2018
6 Reads

Health literacy in men and women with cardiovascular diseases and its association with the use of health care services - Results from the population-based GEDA2014/2015-EHIS survey in Germany.

PLoS One 2018 6;13(12):e0208303. Epub 2018 Dec 6.

Department of Epidemiology and Health Monitoring, Robert Koch Institute Berlin, Berlin, Germany.

Background: Health literacy (HL), defined as the ability to access, understand, appraise and apply health information, offers a promising approach to reduce the development of cardiovascular diseases (CVD) and to improve the management of CVD in populations.

Design: We used data from nationwide cross-sectional German Health Update (GEDA2014/2015-EHIS) survey. 13,577 adults ≥ 40 years completed a comprehensive standardized paper or online questionnaire including the short form of the European Health Literacy Survey Questionnaire (HLS-EU-Q16). Read More

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December 2018
1 Read

Interleukin-6 inhibition of hERG underlies risk for acquired long QT in cardiac and systemic inflammation.

PLoS One 2018 6;13(12):e0208321. Epub 2018 Dec 6.

Cardiovascular Research Program, VA New York Harbor Healthcare System, Brooklyn, New York, United States of America.

Increased proinflammatory interleukin-6 (IL-6) levels are associated with acquired long QT-syndrome (LQTS) in patients with systemic inflammation, leading to higher risks for life-threatening polymorphic ventricular tachycardia such as Torsades de Pointes. However, the functional and molecular mechanisms of this association are not known. In most cases of acquired LQTS, the target ion channel is the human ether-á-go-go-related gene (hERG) encoding the rapid component of the delayed rectifier K current, IKr, which plays a critical role in cardiac repolarization. Read More

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December 2018
1 Read

Gender differences in the relationship between alcohol consumption and insomnia in the northern Chinese population.

PLoS One 2018 6;13(12):e0207392. Epub 2018 Dec 6.

Sanbo Brain Institute, Sanbo Brain Hospital, Capital Medical University, Beijing, China.

Background: Insomnia is one of the main symptoms of sleep disorders. Previous studies have suggested that alcohol intake is associated with several adverse health outcomes. The association between alcohol consumption and insomnia has been addressed in several studies with different results. Read More

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December 2018
3 Reads

Baroreflex function, haemodynamic responses to an orthostatic challenge, and falls in haemodialysis patients.

PLoS One 2018 6;13(12):e0208127. Epub 2018 Dec 6.

Queen Margaret University, Centre of Health, Activity and Rehabilitation Research, Edinburgh, United Kingdom.

Background: Stage 5 chronic kidney disease patients on haemodialysis (HD) often present with dizziness and pre-syncopal events as a result of the combined effect of HD therapy and cardiovascular disease. The dysregulation of blood pressure (BP) during orthostasis may be implicated in the aetiology of falls in these patients. Therefore, we explored the relationship between baroreflex function, the haemodynamic responses to a passive orthostatic challenge, and falls in HD patients. Read More

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December 2018

Association of pre-eclampsia risk with maternal levels of folate, homocysteine and vitamin B12 in Colombia: A case-control study.

PLoS One 2018 6;13(12):e0208137. Epub 2018 Dec 6.

Farr Institute of Health Informatics, University College London, London, United Kingdom.

Background: Maternal serum concentrations of folate, homocysteine, and vitamin B12 have been associated with pre-eclampsia. Nevertheless, reported studies involve limited number of cases to reliably assess the nature of these associations. Our aim was to examine the relation of these three biomarkers with pre-eclampsia risk in a large Colombian population. Read More

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December 2018
1 Read

Molecular insights into vascular aging.

Aging (Albany NY) 2018 Dec 5. Epub 2018 Dec 5.

Division of Cardiovascular Medicine, University of Cambridge, Addenbrooke's Centre for Clinical Investigation, Addenbrooke's Hospital, Cambridge, UK.

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December 2018
1 Read

Not performing an OGTT results in underdiagnosis, inadequate risk assessment and probable cost increases of (pre)diabetes in Han Chinese over 40 years: a population based prospective cohort study.

Endocr Connect 2018 Dec 1. Epub 2018 Dec 1.

L Chen, Endocrinology, Tongji Hospital affiliated with Tongji Medical School of Huazhong University of Science and Technology, Wuhan, 430022, China.

Screening for (pre)diabetes is recommended in China using fasting blood glucose as routine strategy currently but not oral glucose tolerance test (OGTT) in high-risk population. We aimed to explore the impact by not performing an OGTT in Han Chinese over 40 years. 6682 participants were included in the prospective cohort study followed up for 3 years. Read More

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December 2018
3 Reads

Platelet to lymphocyte ratio predicts all-cause mortality in patients with carotid arterial disease.

Rom J Intern Med 2018 Dec 1. Epub 2018 Dec 1.

TOBB Economy and Technology University, Cardiology Department, Ankara, Turkey.

Background: Platelet to lymphocyte ratio (PLR) has been demonstrated as an risk and prognostic marker in many of cardiovascular diseases. Relationship between PLR and severity of carotid stenosis has been shown. The aim of our study was to investigate the relationship between PLR and all cause mortality in patients with carotid arterial disease. Read More

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December 2018

Diet and prevention of type 2 diabetes mellitus: beyond weight loss and exercise.

Expert Rev Endocrinol Metab 2018 Nov 29:1-12. Epub 2018 Nov 29.

a Midwest Biomedical Research/Center for Metabolic and Cardiovascular Health , Glen Ellyn , IL , USA.

Introduction: Insulin resistance (IR) and pancreatic beta-cell dysfunction are core pathophysiologic features of type 2 diabetes mellitus (T2DM). Select lifestyle and pharmacologic interventions, including weight loss, physical activity, a Mediterranean diet intervention, and hypoglycemic agents, have been shown to prevent or delay T2DM. However, dietary factors other than weight loss may also impact risk, mainly through effects to enhance insulin sensitivity, although some may also directly or indirectly impact pancreatic beta-cell function. Read More

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November 2018
4 Reads

Choosing an ideal pharmacotherapeutic strategy for dyslipidemia in children.

Expert Opin Pharmacother 2018 Dec 6:1-4. Epub 2018 Dec 6.

a Biomedical Department of Internal Medicine and Medical Specialties , University of Palermo , Palermo , Italy.

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December 2018
1 Read

microRNA-129-5p is regulated by choline availability and controls EGF receptor synthesis and neurogenesis in the cerebral cortex.

FASEB J 2018 Dec 6:fj201801094RR. Epub 2018 Dec 6.

Nutrition Research Institute, University of North Carolina at Chapel Hill, Kannapolis, North Carolina, USA.

Choline availability modulates neurogenesis and cerebral cortex development through the regulation of neural progenitor cell (NPC) proliferative and differentiation capacity. In this study, we demonstrated that cortical NPC self-renewal is controlled by choline via the expression of a microRNA (miR-129-5p), whose role in the developing brain has not been examined, and which, in turn, inhibits synthesis of the epidermal growth factor receptor (EGFR) protein. Specifically, we found that low choline (LC) availability led to the upregulation of miR-129-5p expression in cortical NPCs in vitro and in vivo, causing the downregulation of EGFR and thereby disrupting NPC self-renewal and cortical neurogenesis. Read More

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December 2018

Hemodynamic Responses to an Exercise Stress Test in Parkinson's Disease Patients without Orthostatic Hypotension.

Appl Physiol Nutr Metab 2018 Dec 6. Epub 2018 Dec 6.

University of Miami, Kinesiology and Sport Sciences, Coral Gable, Florida, United States ;

The presence of postganglionic sympathetic denervation is well established in Parkinson's disease (PD). Denervation at cardiac and blood vessel sites may lead to abnormal cardiovascular and hemodynamic responses to exercise. The aim of the present investigation was to examine how heart rate (HR) and hemodynamics are affected by an exercise test in PD patients without orthostatic hypotension. Read More

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December 2018

Evaluation of magnesium alloys for use as an intraluminal tracheal for pediatric applications in a rat tracheal bypass model.

J Biomed Mater Res B Appl Biomater 2018 Dec 6. Epub 2018 Dec 6.

Department of Bioengineering, University of Pittsburgh, Pittsburgh, Pennsylvania, 15261.

Tracheal stenting currently using non-degradable stents is commonplace for treatment of trauma, prolonged intubation related adult airway obstructions, and pediatric patients-associated tracheal stenosis conditions. Degradable tracheal stent placement will avoid complications of stent removal and restenosis. Widespread reports exist on degradable magnesium alloys success for orthopedic and cardiovascular applications but none to date for intra tracheal use. Read More

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December 2018
2 Reads

Gallic Acid Suppresses Cardiac Hypertrophic Remodeling and Heart Failure.

Mol Nutr Food Res 2018 Dec 6:e1800807. Epub 2018 Dec 6.

Dr. X. Yan, Y.-L. Zhang, L. Zhang, L.-X. Zou, C. Chen, Prof. Y. Liu, Prof. Y.-L. Xia, Prof. H.-H. Li, Department of Nutrition and Food Hygiene, School of Public Health, Dalian Medical University, Dalian, 116044, China.

Scope: Gallic acid (GA) is a dietary phenolic acid found in tea, red wine, and some plants. It exhibits antioxidative and anti-inflammatory activities. Recent studies have revealed that GA has beneficial effects against several cardiovascular diseases; however, whether GA attenuates pressure overload-induced cardiac hypertrophy and the underlying mechanism remain unclear. Read More

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December 2018
2 Reads

Differential associations of depression-related phenotypes with cardiometabolic risks: Polygenic analyses and exploring shared genetic variants and pathways.

Depress Anxiety 2018 Dec 6. Epub 2018 Dec 6.

School of Biomedical Sciences, The Chinese University of Hong Kong, Shatin, Hong Kong.

Background: Numerous studies have suggested associations between depression and cardiometabolic (CM) diseases. However, little is known about the mechanism underlying this comorbidity, and whether the relationship differs by depression subtypes.

Methods: Using polygenic risk scores (PRS) and linkage disequilibrium (LD) score regression, we investigated the genetic overlap of various depression-related phenotypes with a comprehensive panel of 20 CM traits. Read More

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December 2018

Predictors associated with an increased prevalence of postimplantation syndrome after thoracic endovascular aortic repair for type B aortic dissection.

Eur J Cardiothorac Surg 2018 Dec 5. Epub 2018 Dec 5.

Department of Cardiology, Vascular Center, Guangdong Cardiovascular Institute, Guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.

Objectives: The aim of this study was to identify patients who are at high risk of developing postimplantation syndrome (PIS) after thoracic endovascular aortic repair (TEVAR) for type B aortic dissection.

Methods: This retrospective study included 646 patients who underwent TEVAR for type B aortic dissection between January 2010 and December 2015 at the Guangdong General Hospital. PIS was defined as fever (>38°C) and leucocytosis (>12 000 μl-1) without evidence of infection. Read More

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December 2018

Heart Rate Variability Predicts Older Adults' Avoidance of Negativity.

J Gerontol B Psychol Sci Soc Sci 2018 Dec 6. Epub 2018 Dec 6.

Department of Psychology, University of Warwick, Coventry, UK.

Objectives: The ability to produce situation-appropriate cognitive and emotional responses is dependent on autonomic nervous system (ANS) functionality. Heart rate variability (HRV) is an index of ANS functionality, and resting HRV levels have been associated with cognitive control and inhibitory capacity in young adults, particularly when faced with emotional information. As older adults' greater preference for positive and avoidance of negative stimuli (positivity effect) is thought to be dependent on cognitive control, we hypothesized that HRV could predict positivity-effect magnitude in older adults. Read More

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December 2018
2 Reads

Concurrent Developmental Course of Sleep Problems and Emotional/behavioral Problems in Childhood and Adolescence as Reflected by the Dysregulation Profile.

Sleep 2018 Dec 6. Epub 2018 Dec 6.

Centre and Discipline of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, The University of Western Australia, Perth, WA, Australia.

Objectives: Longitudinal data on the course and relationship of concurrent psychopathology in youth are scarce but are of need for better practical patient care and prevention. This study explores the course of (and relationships over time) between sleep problems and concurrent dimensional difficulties relating to anxiety/depression, attention deficiency and aggressive behaviors in childhood and adolescence. The latter three may jointly form a broad syndrome, the dysregulation profile. Read More

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December 2018

Emerging evidence of an effect of salt on innate and adaptive immunity.

Nephrol Dial Transplant 2018 Dec 5. Epub 2018 Dec 5.

Department of Renal Medicine, University College London (UCL), London, UK.

Salt intake as part of a western diet currently exceeds recommended limits, and the small amount found in the natural diet enjoyed by our Paleolithic ancestors. Excess salt is associated with the development of hypertension and cardiovascular disease, but other adverse effects of excess salt intake are beginning to be recognized, including the development of autoimmune and inflammatory disease. Over the last decade there has been an increasing body of evidence demonstrating that salt affects multiple components of both the innate and adaptive immune systems. Read More

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December 2018
1 Read

Glomerular filtration rate: when to measure and in which patients?

Nephrol Dial Transplant 2018 Dec 6. Epub 2018 Dec 6.

Department of Nephrology, Dialysis, Transplantation, University of Liège (CHU ULg), Liège, Belgium.

Of the glomerular, tubular and endocrine functions of the kidney, nephrologists have mostly focused their attention on the glomerular functions-albuminuria and glomerular filtration rate (GFR)-to grade the severity of chronic kidney disease (CKD). Although both albuminuria and GFR are associated with renal and cardiovascular morbidity and mortality, the utility of measured GFR (mGFR) has been questioned. GFR when measured adequately is the most precise measure of glomerular function and can be useful to individualize therapy among patients with CKD. Read More

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December 2018
2 Reads

Prospective, randomized trial of bioresorbable scaffolds vs. everolimus-eluting stents in patients undergoing coronary stenting for myocardial infarction: the Intracoronary Scaffold Assessment a Randomized evaluation of Absorb in Myocardial Infarction (ISAR-Absorb MI) trial.

Eur Heart J 2018 Dec 5. Epub 2018 Dec 5.

Department of Cardiovascular Diseases, Deutsches Herzzentrum München, Technische Universität München, Lazarettstrasse 36, Munich, Germany.

Aims: Bioresorbable scaffolds (BRS) provide short-term coronary artery scaffolding and drug delivery. Although prior trials showed a higher rate of device failure compared with conventional drug-eluting stents (DES), only a single trial investigated patients undergoing percutaneous coronary intervention (PCI) for acute myocardial infarction (MI). We aimed to compare outcomes with BRS vs. Read More

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December 2018

Association of Audiometric Age-Related Hearing Loss With Depressive Symptoms Among Hispanic Individuals.

JAMA Otolaryngol Head Neck Surg 2018 Dec 6. Epub 2018 Dec 6.

Department of Psychiatry, New York State Psychiatric Institute, Vagelos College of Physicians and Surgeons, NewYork-Presbyterian/Columbia University Irving Medical Center, Columbia University, New York.

Importance: Age-related hearing loss is highly prevalent and has recently been associated with numerous morbid conditions of aging. Late-life depression is also prevalent and can be resistant to available treatments. Preliminary studies examining the association between hearing loss and late-life depression have been limited by subjective hearing measures, small sample sizes, and primarily white populations. Read More

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December 2018
7 Reads

Pretest probability for patients with suspected obstructive coronary artery disease: re-evaluating Diamond-Forrester for the contemporary era and clinical implications: insights from the PROMISE trial.

Eur Heart J Cardiovasc Imaging 2018 Dec 5. Epub 2018 Dec 5.

Cardiac MR PET CT Program, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, 165 Cambridge Street, Suite 400, Boston, USA.

Aims: To update pretest probabilities (PTP) for obstructive coronary artery disease (CAD ≥ 50%) across age, sex, and clinical symptom strata, using coronary computed tomography angiography (CTA) in a large contemporary population of patients with stable chest pain referred to non-invasive testing.

Methods And Results: We included patients enrolled in the Prospective Multicenter Imaging Study for Evaluation of Chest Pain (PROMISE) trial and randomized to CTA. Exclusively level III-certified readers, blinded to demographic and clinical data, assessed the prevalence of CAD ≥ 50% in a central core lab. Read More

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December 2018
1 Read

Loss of CXCR4 on non-classical monocytes in participants of the Women's Interagency HIV Study (WIHS) with subclinical atherosclerosis.

Cardiovasc Res 2018 Dec 5. Epub 2018 Dec 5.

La Jolla Institute of Immunology, La Jolla, California, USA.

Aims: To test whether human immunodeficiency virus (HIV) infection and subclinical cardiovascular disease (sCVD) are associated with expression of CXCR4 and other surface markers on classical, intermediate, and non-classical monocytes in women.

Methods And Results: sCVD was defined as presence of atherosclerotic lesions in the carotid artery in 92 participants of the Women's Interagency HIV Study (WIHS). Participants were stratified into 4 sets (n = 23 each) by HIV and sCVD status (HIV-/sCVD-, HIV-/sCVD+, HIV+/sCVD-, HIV+/sCVD+) matched by age, race/ethnicity, and smoking status. Read More

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December 2018

SecScan: a general approach for mapping disulfide bonds in synthetic and recombinant peptides and proteins.

Chem Commun (Camb) 2018 Dec 6. Epub 2018 Dec 6.

Department of Biochemistry, University of Maastricht, Cardiovascular Research Institute Maastricht (CARIM), Universiteitssingel 50, 6229 ER, Maastricht, The Netherlands.

Selenocysteine scanning (SecScan) is a novel technique to map disulfide networks in proteins independent of structure-based distance information and mass spectrometry. SecScan applies systematic substitution of single Cys by Sec in combination with NMR spectroscopy for reliable and unambiguous determination of disulfide bond networks. Read More

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December 2018
1 Read

Council on Cardiovascular and Stroke Nursing Liaison Report.

J Cardiovasc Nurs 2019 Jan/Feb;34(1):9-10

Anne M. Fink, PhD, RN, FAHA Assistant Professor, College of Nursing, University of Illinois at Chicago. Ruth E. Taylor-Piliae, PhD, RN, FAHA Associate Professor, College of Nursing, University of Arizona, Tucson.

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December 2018

Nurses Are Key in Preventing Deadly Diagnostic Errors in Cardiovascular Diseases.

J Cardiovasc Nurs 2019 Jan/Feb;34(1):6-8

Kelly T. Gleason, PhD, RN Assistant Professor, School of Nursing, Johns Hopkins University, Baltimore, Maryland. Penny Greenberg, MS, RN, CPPS Senior Program Director, Patient Safety Services, Controlled Risk Insurance Company Strategies Boston, Massachusetts. Cheryl R. Dennison Himmelfarb, PhD, RN, ANP, FAAN Professor, School of Nursing, Johns Hopkins University, Baltimore, Maryland.

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December 2018
5 Reads
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