1,330 results match your criteria Cardiovascular Journal Of Africa[Journal]


The safety and efficacy of pharmaco-mechanical thrombolysis in lower-extremity deep venous thrombosis.

Cardiovasc J Afr 2020 Jun 19;31:1-5. Epub 2020 Jun 19.

Çanakkale Onsekiz Mart University, Çanakkale, Turkey.

Objective: The aim of this study was to investigate the impact of accelerated pharmaco-mechanical thrombolysis (PMT) with low-dose second-generation urokinase for the management of cases with lower-extremity deep venous thrombosis (DVT), and to compare its efficacy in subjects with acute and subacute DVT.

Methods: Thirty-five patients with acute (< 15 days) or subacute (15-30 days) DVT who underwent PMT in a tertiary centre were enrolled in this single-arm, prospective study. Following the placement of a temporary vena cava filter, urokinase (200 000 IU) was administered into the occlusion through a multi-hole catheter for 15 to 20 minutes. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5830/CVJA-2020-020DOI Listing

Patterns of cardiovascular risk and disease in HIV-positive adults on anti-retroviral therapy in Mozambique.

Cardiovasc J Afr 2020 Jun 19;31:1-5. Epub 2020 Jun 19.

National Institute of Health, Mozambique; Eduardo Mondlane University, Maputo, Mozambique. Email:

Introduction: With improved access to anti-retroviral therapy (ART) the focus of HIV treatment is changing to reducing chronic co-morbidities and their effects, but guidelines for HIV care in many African countries do not include screening for cardiac disease. Our study aimed to determine the pattern of cardiac abnormalities in HIV-positive patients on ART.

Methods: We implemented a prospective, observational study for 24 months on a random sample of adult patients seen at a dedicated HIV clinic in Mozambique. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5830/CVJA-2020-007DOI Listing

Clinical spectrum and prevalence of congenital heart disease in children in Botswana.

Cardiovasc J Afr 2020 Jun 22;31:1-5. Epub 2020 Jun 22.

Department of Paediatric and Adolescent Health, Faculty of Medicine, University of Botswana, Gaborone, Botswana; Department of Paediatrics, Princess Marina Hospital, Gaborone, Botswana.

Background: Reliable data on congenital heart disease (CHD) from diverse settings is important both for planning health systems in each country and to elucidate possible aetiologies of CHD in different settings. There is a lack of data on the clinical spectrum and prevalence of CHD in Botswana. The aim of this study was to describe the clinical spectrum and prevalence of CHD in Botswana. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5830/CVJA-2020-021DOI Listing

Subclinical anthracycline therapy-related cardiac Dysfunction: an ignored stage B heart failure in an African population.

Cardiovasc J Afr 2020 Jun 24;31:1-5. Epub 2020 Jun 24.

Hatter Institute for Cardiovascular Research in Africa, University of Cape Town, Cape Town, South Africa.

Anthracyclines are potent antineoplastic agents with a proven efficacy in the treatment of many paediatric and adult haematological and solid-organ cancers. Anthracycline therapy-related cardiac dysfunction (ATRCD) is the commonest and most well-studied chemotherapy-induced cardiovascular toxicity. Therefore patients who received anthracycline therapy are considered in stage A heart failure. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5830/CVJA-2020-013DOI Listing

Effect of invasive strategy on long-term mortality in elderly patients presenting with acute coronary syndrome.

Cardiovasc J Afr 2020 Jun 22;31:1-5. Epub 2020 Jun 22.

Cardiology Department, Pamukkale University Hospitals, Pamukkale, Denizli, Turkey.

Objective: The elderly have the highest incidence of cardiovascular disease and frequently present with acute coronary syndrome (ACS). In this study, our aim was to evaluate the effect of an invasive strategy on long-term mortality in patients of 80 years and older presenting with ACS.

Methods: Patients who were admitted to hospital with ACS were recruited using appropriate ICD codes in the computerised hospital data system. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5830/CVJA-2020-011DOI Listing

Persistent cardiac arrest caused by profound hypokalaemia after large-dose insulin injection in a young man with type 1 diabetes mellitus: successful rescue with extracorporeal membrane oxygenation and subsequent ventricular assist device.

Cardiovasc J Afr 2020 Jul 6;31:1-4. Epub 2020 Jul 6.

Division of Cardiovascular Surgery, Department of Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan. Email:

A 28-year-old man who had a history of type 1 diabetes mellitus with poor medication compliance was referred to the emergency department of our institute with suspected diabetic ketoacidosis. The patient developed sudden cardiac arrest following continuous insulin administration. Laboratory data revealed severe hypokalaemia. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5830/CVJA-2020-018DOI Listing

Feasibility and effect of community health worker support and home monitoring for blood pressure control in Nigeria: a randomised pilot trial.

Cardiovasc J Afr 2020 May/Jun;31(3):e4-e6

Department of Preventive Medicine, Northwestern University, Feinberg School of Medicine, Chicago, Illinois, USA.

In a three-arm, randomised, controlled trial among 60 Nigerian adults with hypertension, community health worker support and home blood pressure monitoring led to greater reductions in systolic blood pressure at four weeks compared to the usual care. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5830/CVJA-2019-066DOI Listing
September 2019

The inaugural meeting of the Africa Heart Rhythm Association (AFHRA).

Cardiovasc J Afr 2020 May/Jun;31(3):162-164

West Yorkshire Arrhythmia Service, Leeds General Infirmary, Leeds, UK.

Cardiorhythm Africa, the inaugural conference of AFHRA, was conceived during the biennial PASCAR congress held in Johannesburg in November 2019, with the ambition to be the largest ever pan-African conference focused purely on arrhythmia. Significant aims were to (1) bring together arrhythmia specialists from across Africa and from the diaspora; and (2) announce the newly formed African Heart Rhythm Association (AFHRA), an affiliate organisation of PASCAR formed from the amalgamation of the Cardiac Pacing and Arrhythmias taskforces. The meeting held in Nairobi (29-31 January 2020) was organised to provide a focus on resource-constrained arrhythmia management within the African context and novel/advanced and potentially home-grown solutions. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5830/CVJA-2020-019DOI Listing

The acute coronary syndrome revisited: effects and therapeutic modulation of excess metabolic fuel supply.

Cardiovasc J Afr 2020 May/Jun;31(3):159-161

Hatter Institute for Cardiovascular Research in Africa, Department of Medicine, University of Cape Town and Groote Schuur Hospital, Cape Town, South Africa.

View Article

Download full-text PDF

Source

Cardiovascular care in sub-Saharan Africa during the COVID-19 crisis: lessons from the global experience.

Cardiovasc J Afr 2020 May/Jun;31(3):113-115

The Cardiac Clinic, Groote Schuur Hospital and University of Cape Town, South Africa. Email:

View Article

Download full-text PDF

Source

Cardiac surgery-associated acute kidney injury: pathophysiology and diagnostic modalities and management.

Cardiovasc J Afr 2020 Jun 12;31:1-8. Epub 2020 Jun 12.

Department of Anaesthesiology, University of the Witwatersrand, Charlotte Maxeke Johannesburg Academic Hospital, Johannesburg, South Africa.

Acute kidney injury is a disease spectrum that can present with from mild renal dysfunction to complete renal failure that would require renal replacement therapy. Cardiac surgery-associated acute kidney injury is a complication that carries a grave disease burden. Risk factors are identified as being either modifiable or non-modifiable. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5830/CVJA-2019-069DOI Listing

Short-term efficacy and safety of levosimendan in patients with chronic systolic heart failure.

Cardiovasc J Afr 2020 Jun 12;31:1-5. Epub 2020 Jun 12.

The Sixth Department of Cardiovascular Medicine, Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, China. Email:

The objective was to investigate and evaluate the short-term efficacy and safety of levosimendan in patients with chronic systolic heart failure. Forty-nine patients with chronic systolic heart failure during acute decompensation were randomly divided into a levosimendan group (26 cases) and a control group (23 cases). The control group received only routine treatment, while the levosimendan group received a levosimendan bolus with a load of 12 µg/kg, in addition to the same routine treatment as the control group. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5830/CVJA-2020-008DOI Listing

Primary PCI in the management of STEMI in sub-Saharan Africa: insights from Abidjan Heart Institute catheterisation laboratory.

Cardiovasc J Afr 2020 Jun 12;31:1-4. Epub 2020 Jun 12.

Intensive Care Unit, Abidjan Heart Institute, Abidjan, Côte d'Ivoire.

Background: Implementation of primary percutaneous coronary intervention (PCI) in sub-Saharan Africa remains a challenging issue. The aim of this study was to report the results of primary PCI and outcomes in the catheterisation laboratory of the Abidjan Heart Institute.

Methods: Between April 2010 and March 2019, all patients aged 18 years presenting to the Abidjan Heart Institute for ST-segment elevation myocardial infarction (STEMI) over the study period and who underwent primary PCI were included. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5830/CVJA-2020-012DOI Listing

Idiopathic hypereosinophilic syndrome associated with rapid progression of cardiac, pulmonary and skin infiltration.

Cardiovasc J Afr 2020 Jun 12;31:1-7. Epub 2020 Jun 12.

Department of Cardiology, China-Japan Union Hospital of Jilin University, Cardiovascular Institute of Jilin Province, Changchun 130033, Jilin Province, China.

Idiopathic hypereosinophilic syndrome (IHES) is a rare myeloproliferative disease characterised by multisystem dysfunction and persistent, extreme eosinophilia of unknown cause. Here we present a 42-year-old patient complaining of moderate to severe chest pain and shortness of breath, and typical ischaemic electrocardiography changes were recorded. He was initially suspected of having acute coronary syndrome, however the coronary angiogram excluded coronary abnormalities. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5830/CVJA-2020-009DOI Listing

Internal thoracic artery pseudoaneurysm after redo aortic root replacement.

Cardiovasc J Afr 2020 Jun 16;31:1-3. Epub 2020 Jun 16.

Division of Cardiovascular Surgery, Department of Surgery II, Faculty of Medicine, Yamagata University, Yamagata, Japan.

Pseudoaneurysm of the internal thoracic artery (ITA) or bleeding from the ITA is an extremely rare complication after cardiovascular surgery via a median sternotomy. Early treatment is needed in the case of massive haemorrhage or a rapidly enlarging pseudoaneurysm. Herein, we present a rare case of a delayed large pseudoaneurysm of the right ITA in a 49-year-old woman with Marfan syndrome who underwent redo aortic root replacement via re-median sternotomy and pacemaker implantation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5830/CVJA-2020-014DOI Listing

Coronavirus disease 2019 (COVID-19) and simultaneous acute anteroseptal and inferior ST-segment elevation myocardial infarction.

Cardiovasc J Afr 2020 May 5;31:1-4. Epub 2020 May 5.

Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Istanbul Yeni Yuzyil University, Gaziosmanpasa Hospital, Gaziosmanpasa, Istanbul, Turkey.

Coronavirus disease 2019 (COVID-19) is a recently recognised pandemic spreading rapidly from Wuhan, Hubei, to other provinces in China and to many countries around the world. The number of COVID-19-related deaths is steadily increasing. Acute ST-segment elevation myocardial infarction (STEMI) is a disease with high morbidity and mortality rates, and primary percutaneous coronary intervention is usually recommended for the treatment. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5830-CVJA-2020-016DOI Listing

Tricuspid valve vegetation related to leaflet injury: a unique problem of catheter malposition.

Cardiovasc J Afr 2020 Jun 1;31:1-4. Epub 2020 Jun 1.

Institute of Cardiology, The First Affilliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.

The use of peripherally inserted central catheters (PICCs) has expanded substantially for drug delivery in clinical practice in recent years. However, PICC lines expose patients to potential complications associated with an increasing incidence of infective endocarditis. We herein report a case of a 57-year-old woman who was diagnosed with tricuspid valve endocarditis by echocardiography. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5830/CVJA-2020-005DOI Listing

Coronavirus disease 2019 (COVID-19) and simultaneous acute anteroseptal and inferior ST-segment elevation myocardial infarction.

Cardiovasc J Afr 2020 May 5;31:1-4. Epub 2020 May 5.

Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Istanbul Yeni Yuzyil University, Gaziosmanpasa Hospital, Gaziosmanpasa, Istanbul, Turkey.

Coronavirus disease 2019 (COVID-19) is a recently recognised pandemic spreading rapidly from Wuhan, Hubei, to other provinces in China and to many countries around the world. The number of COVID-19-related deaths is steadily increasing. Acute ST-segment elevation myocardial infarction (STEMI) is a disease with high morbidity and mortality rates, and primary percutaneous coronary intervention is usually recommended for the treatment. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10-5830-CVJA-2020-016DOI Listing

A giant aneurysm of the left anterior descending coronary artery in the setting of Behcet's disease.

Cardiovasc J Afr 2020 Jan/Feb;31(1):e1-e3

Cardiology Department, Cardiothrombosis Research Laboratory, University of Monastir and Fattouma Bourguiba University Hospital, Monastir, Tunisia. Email:

Behcet's disease is a chronic inflammatory syndrome that can affect arteries and veins of all sizes and is an unusual cause of myocardial infarction. We report a case of a 42-year-old male with no cardiovascular risk factors who was referred to our department for a spontaneously resolving anterior ST-elevation myocardial infarction. Clinical and biological investigations revealed a high probability for Behcet's disease. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5830/CVJA-2019-031DOI Listing

What cardiology training and cardiac procedural training does Africa need?

Authors:
Pat Commerford

Cardiovasc J Afr 2020 Jan/Feb;31(1)

Editor-in-Chief.

View Article

Download full-text PDF

Source

Endothelial dysfunction in HIV-positive patients with acute coronary syndromes.

Cardiovasc J Afr 2020 Mar 19;31:1-7. Epub 2020 Mar 19.

Division of Cardiology, Department of Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.

Aim: This study investigated endothelial function in HIV-positive patients with acute coronary syndrome (ACS). Flow-mediated dilatation, pulse-wave velocity, carotid intima-media thickness and endothelial biomarkers were used to non-invasively investigate endothelial dysfunction.

Methods: Twenty HIV-positive patients with ACS (HIV+/ACS) were compared to 20 HIV-negative patients with ACS (HIV-/ACS) and 20 HIV-positive patients without ACS (HIV+/no ACS). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5830/CVJA-2019-040DOI Listing

Treatment of atrial fibrillation: a comprehensive review and practice guide.

Cardiovasc J Afr 2020 Mar 18;31:1-6. Epub 2020 Mar 18.

Department of Cardiology, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan 250014, PR China. Email:

Atrial fibrillation (AF) is an ectopic rhythm originating in the atrium. AF is the most common sustained cardiac arrhythmia in clinical practice and it is an enormous burden worldwide because of the high rates of morbidity, disability and mortality. Treatment of AF has become a hot spot in the field of cardiovascular medicine. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5830/CVJA-2019-064DOI Listing

Incidence and risk factors for thromboembolism and major bleeding in patients with mechanical heart valves: a tertiary hospital-based study in Botswana.

Cardiovasc J Afr 2020 Mar 16;31:1-5. Epub 2020 Mar 16.

University of Botswana, Gaborone, Botswana.

Introduction: Mechanical heart valve (MHV) prostheses increase the risk of thromboembolic complications. While warfarin anticoagulation reduces this risk, its use increases the risk of bleeding. We sought to estimate the rate of thromboembolic and bleeding complications among patients with MHVs at a tertiary hospital in Botswana. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5830/CVJA-2020-006DOI Listing

Early Supera stent fracture in the femoropopliteal artery.

Cardiovasc J Afr 2020 May/Jun 23;31(3):e1-e3. Epub 2020 Mar 17.

Divison of Cardiology, Yeungnam University Medical Centre, Daegu, Republic of Korea. Email:

The Supera peripheral stent has been designed to resist stent fracture, which can develop from the torsion and compressive forces in the femoropopliteal artery. We report on a case of Supera peripheral stent fracture in the early period after the index procedure in a patient with femoropopliteal artery disease. An individualised approach, considering the lesion location, patient's age and exercise capacity is important for the treatment of femoropopliteal artery disease. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5830/CVJA-2020-004DOI Listing

Family screening in black patients with isolated left ventricular non-compaction: the Chris Hani Baragwanath experience.

Cardiovasc J Afr 2020 Mar 11;31:1-5. Epub 2020 Mar 11.

Charlotte Maxeke Johannesburg Academic Hospital, University of the Witwatersrand, Johannesburg, South Africa.

Background: Isolated left ventricular non-compaction (ILVNC), dilated cardiomyopathy (DCMO) and hypertrophic cardiomyopathy (HCM) are diseases that may be present in family members of patients with ILVNC. The primary aim of this study was to identify the prevalence and spectrum of cardiomyopathy in first-degree relatives of patients with ILVNC. A secondary aim was to compare a strategy of clinical screening, utilising only a clinical assessment and electrocardiogram (ECG), compared to one that included echocardiography for screening of family members of patients with ILVNC. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5830/CVJA-2020-003DOI Listing

Impact of metabolic and inflammatory changes on glomerular function beyond conventional risk factors in an urban South Africa community with prevalent obesity.

Cardiovasc J Afr 2020 Mar 11;31:1-12. Epub 2020 Mar 11.

Cardiovascular Pathophysiology and Genomics Research Unit, School of Physiology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.

Objectives: To determine the extent to which metabolic and inflammatory changes are associated with renal damage beyond conventional risk factors in a community sample with a high prevalence of obesity in urban South Africa.

Methods: This was a cross-sectional, community-based study in 1 010 ( = 872 without diabetes mellitus, DM) randomly selected participants over 16 years of age in an urban, developing community (Soweto, Johannesburg) with a high prevalence of obesity (41.8%). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5830/CVJA-2019-057DOI Listing

Effect of heroin on right ventricular cardiac performance.

Cardiovasc J Afr 2020 Mar 5;31:1-4. Epub 2020 Mar 5.

Department of Cardiology, Van Education and Research Hospital, University of Health Sciences, Van, Turkey.

Objective: The aim of this study was to investigate the effects of heroin addiction, which is an important social and health problem, on right cardiac function.

Methods: A total of 85 individuals were included in the study. The study group comprised 45 patients smoking heroin and the control group was 40 healthy individuals with no drug addiction. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5830/CVJA-2020-002DOI Listing

Rooibos () protects against nicotineinduced vascular injury and oxidative stress in Wistar rats.

Cardiovasc J Afr 2020 Feb 7;31:1-10. Epub 2020 Feb 7.

Centre for Cardio-metabolic Research in Africa, Division of Medical Physiology, Biomedical Sciences, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, South Africa.

Background: Rooibos () is an indigenous South African plant, traditionally used by the local population as a remedy against several ailments. More recently, rooibos was shown to exhibit potent antioxidant properties, attributed to its polyphenols. We assessed whether treatment with fermented rooibos (RF), unfermented rooibos (RUF) and melatonin (Mel), a well-documented antioxidant included for comparison, could counter the harmful vascular and pro-oxidant effects of nicotine. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5830/CVJA-2019-052DOI Listing
February 2020

Echocardiographic abnormalities in children and adolescents living with human immunodeficiency virus on highly active antiretroviral treatment.

Cardiovasc J Afr 2020 Feb 5;31:1-6. Epub 2020 Feb 5.

Department of Paediatrics and Adolescent Health, Division of Cardiology, Faculty of Medicine, University of Botswana, Gaborone, Botswana. Email:

Background: The availability and use of highly active antiretroviral treatment (HAART) has turned human immunodeficiency virus (HIV) into a chronic disease, allowing patients to live much longer.

Objectives: To report asymptomatic cardiac abnormalities in children and adolescents based on both conventional and tissue Doppler imaging (TDI) echocardiography.

Methods: One hundred and fifty-one patients on HAART were recruited. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5830/CVJA-2019-072DOI Listing
February 2020

Association between galectin-3 levels and isolated coronary artery ectasia.

Cardiovasc J Afr 2020 May/Jun 23;31(3):147-152. Epub 2020 Feb 5.

Department of Cardiology, Faculty of Medicine, Istanbul Medeniyet University, Istanbul, Turkey.

Background: Coronary artery ectasia (CAE) is a well-recognised disorder characterised by abnormal dilation of the coronary arteries. Underlying mechanisms associated with abnormal luminal dilation in CAE remain to be elucidated. However, histopathological features resemble those of coronary atherosclerosis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5830/CVJA-2019-070DOI Listing
February 2020

Mitochondrial oxidative phosphorylation and mitophagy in myocardial ischaemia/reperfusion: effects of chloroquine.

Cardiovasc J Afr 2019 Dec 12;30:1-11. Epub 2019 Dec 12.

Division of Medical Physiology, Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, University of Stellenbosch, South Africa. Email:

Aim: The aim of this study was to evaluate the temporal relationship between mitochondrial oxidative phosphorylation and mitophagy in rat hearts subjected to ischaemia/reperfusion. Measurements were made at specific points during the experimental protocol (snapshot approach) and by assessments of mitophagic flux, using chloroquine pre-treatment.

Methods: Isolated working rat hearts were subjected to 25 or 30 minutes of global ischaemia/10 minutes of reperfusion. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5830/CVJA-2019-067DOI Listing
December 2019

Cardiovascular assessment after treatment for retinopathy of prematurity: a comparative study between anti-VEGF agent (aflibercept) and laser.

Cardiovasc J Afr 2020 May/Jun 23;31(3):123-129. Epub 2020 Jan 13.

Department of Ophthalmology, Adana City Education and Research Hospital, Adana, Turkey.

Objective: The aim of this study was to compare the cardiac effects and aortic arterial indices following intravitreal aflibercept treatment or diode laser photocoagulation for the treatment of retinopathy of prematurity (ROP) in infants.

Methods: This single-centre, retrospective study was conducted in infants who were administered laser photocoagulation (LPC) or intravitreal aflibercept (IVA) treatment as initial treatment and had completed at least one year of corrected age. The patients were evaluated in terms of aortic elastic parameters, right and left ventricular systolic and diastolic function using conventional, pulsed Doppler and tissue Doppler imaging (TDI) echocardiographic parameters. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5830/CVJA-2019-058DOI Listing
January 2020

Cardiac pacing in sub-Saharan Africa.

Cardiovasc J Afr 2020 Jan/Feb 23;31(1):3-4. Epub 2020 Jan 14.

Groote Schuur Hospital/University of Cape Town, South Africa.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5830/CVJA-2020-001DOI Listing
January 2020

Large left ventricular non-infectious vegetation in patient with eosinophilic granulomatosis with polyangiitis.

Cardiovasc J Afr 2020 Jan 29;31:1-4. Epub 2020 Jan 29.

Department of Pathology, Haeundae Paik Hospital, Inje University College of Medicine, Busan, Korea.

Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare form of systemic vasculitis in which cardiac involvement is relatively common and accounts for half of EGPA-related deaths. Cardiac involvement is more frequent in patients with an absence of anti-neutrophil cytoplasmic antibody and those with higher eosinophil counts. Clinical manifestations are various, including myocarditis, pericarditis, pericardial effusion, heart failure, arrhythmias, valvular insufficiencies and intra-cardiac thrombus formation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5830/CVJA-2019-065DOI Listing
January 2020

A 31-year-old pericardial textiloma.

Cardiovasc J Afr 2019 Dec 9;30:1-4. Epub 2019 Dec 9.

Department of Thoracic and Cardiovascular Surgery, Ulsan University Hospital, Ulsan University Medical School, Ulsan, Republic of Korea . Email:

Gossypibomas are uncommon but important complications of surgery. This case report is of a gossypiboma found accidentally 31 years after heart surgery. A 41-year-old man had lost 5 kg in the previous three months and suffered from intermittent epigastric discomfort. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5830/CVJA-2019-068DOI Listing
December 2019

A primary aldosteronism-like phenotype identified with the aldosterone-to-angiotensin II ratio in black men: the SABPA study.

Cardiovasc J Afr 2019 Nov 27;30:1-6. Epub 2019 Nov 27.

Hypertension in Africa Research Team (HART), North-West University, Potchefstroom, South Africa; South African Medical Research Council: Unit for Hypertension and Cardiovascular Disease, North-West University, Potchefstroom, South Africa.

Introduction: Black populations may be more likely to have primary aldosteronism (PA) due to adrenal hyperplasia or other forms of adrenal hyperactivity, with suppressed renin levels and high levels of aldosterone, which may contribute to the development of hypertension.

Methods: This sub-study involved 35 black men matched for age, gender and race, and aged 20-65 years, living in the North West Province of South Africa. RAAS triple-A analysis was carried out with LC-MS/MS quantification. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5830/CVJA-2019-059DOI Listing
November 2019

Prevalence of hypertension and selected cardiovascular risk factors among adolescents in selected rural and urban secondary schools in Botswana.

Cardiovasc J Afr 2019 Nov 27;30:1-6. Epub 2019 Nov 27.

Department of Internal Medicine, Faculty of Medicine, University of Botswana; Department of Internal Medicine, Princess Marina Hospital, Gaborone, Botswana.

Background: Adolescent hypertension and other cardiovascular risk factors tend to track into adulthood. Consequently, there is a need to determine the prevalence of hypertension and pre-hypertension, and its co-existence with glycaemia, obesity, tobacco and alcohol use among senior secondary school students in Botswana.

Methods: A cross-sectional study was undertaken between December 2015 and March 2016 among students in selected rural and urban senior secondary schools in Botswana. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5830/CVJA-2019-062DOI Listing
November 2019

Healthy Heart Africa: a prospective evaluation of programme outcomes on individuals' hypertension awareness, screening, diagnosis and treatment in rural Kenya at 12 months.

Cardiovasc J Afr 2020 Jan/Feb 23;31(1):9-15. Epub 2019 Nov 27.

Clinical Medicine and Therapeutics, University of Nairobi, Nairobi, Kenya.

Objective: To evaluate the impact of Healthy Heart Africa (HHA), a comprehensive hypertension intervention programme, on hypertension awareness, knowledge, screening and diagnosis among rural communities in Kenya.

Methods: Individuals from rural households near intervention and matched control healthcare facilities were randomly surveyed at baseline and the end point (after 12 months). A difference-in-differences analysis estimated the impact of HHA. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5830/CVJA-2019-037DOI Listing
November 2019

PASCAR and WHF Cardiovascular Diseases Scorecard project.

Cardiovasc J Afr 2019 Sep/Oct;30(5):305-310

College of Medicine, National University, Khartoum, Sudan.

On behalf of the World Heart Federation, the Pan-African Society of Cardiology (PASCAR) co-ordinated data collection and reporting for the country-level Cardiovascular Diseases (CVD) Scorecard to be used in Africa. The objective of the scorecard is to create a clear picture of the current state of CVD prevention, control and management per country for 12 African countries. The Sudan Heart Society assisted PASCAR in collating and verifying the data through Drs Awad Mohamed (president, Sudan Heart Society) and Saad Subahi (PASCAR president, based in Sudan). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5830/CVJA-2019-063DOI Listing

Familial hypercholesterolaemia workshop for leveraging point-of-care testing and personalised medicine in association with the Lipid and Atherosclerosis Society of Southern Africa.

Cardiovasc J Afr 2019 Sep/Oct;30(5):297-304

Centre for Cardiovascular Genetics, Institute of Cardiovascular Science, University College London, London, United Kingdom.

Familial hypercholesterolaemia (FH) is a common autosomal dominantly inherited disorder in which impaired clearance of plasma low-density lipoprotein cholesterol causes premature atherosclerotic vascular disease and tendon xanthomata. This workshop aimed to consolidate information on the diagnosis and management of FH in South Africa. The genetic causes include mutations in the LDL receptor, apolipoprotein B100 and proprotein convertase subtilisin/kexin type 9 (PCSK9). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5830/CVJA-2019-055DOI Listing

Renal denervation: dark past, bright future?

Cardiovasc J Afr 2019 Sep/Oct;30(5):290-296

Department of Internal Medicine, Stellenbosch University, Cape Town, South Africa.

The purpose of this review is to update the reader on the relevance of autonomic nervous system imbalance in clinical cardiology. Increased sympathetic tone associates with the metabolic syndrome, hypertension and cardiac arrhythmias. With the kidneys playing a pivotal role in increased peripheral resistance, sodium and water retention and other mechanisms, renal denervation (RD) may theoretically restore autonomic imbalance and improve cardiovascular outcomes. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5830/CVJA-2019-045DOI Listing

Ellisras Longitudinal Study 2017: patterns of physical activity in an urban and rural setting among black South African adults (ELS 23).

Cardiovasc J Afr 2019 Sep/Oct;30(5):262-267

School of Public Health, University of the Western Cape, Cape Town, South Africa.

Background: Understanding patterns of physical activity among adults can lead to targeted approaches to improve activity levels in the African population. This study aimed to determine whether age, gender, location and employment status could predict physical activity among rural and urban South African adults, and to determine the participants' risk of developing cardiovascular disease (CVD).

Methods: A cross-sectional design was conducted on 319 participants of mean age 57 ± 10. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5830/CVJA-2019-018DOI Listing

Ellisras Longitudinal Study 2017: association of hypertension with increasing levels of adiposity in 10- to 14-year-old boys and girls in the Eastern Cape (ELS 31).

Cardiovasc J Afr 2019 Sep/Oct;30(5):258-261

Department of Biological and Environmental Sciences, Walter Sisulu University, Mthatha, South Africa. Email:

Objectives: Previous studies suggest a strong relationship between obesity and hypertension. This study aimed at evaluating the prevalence of hypertension and pre-hypertension in 10- to 14-year-old boys and girls in the Eastern Cape Province of South Africa and to determine the association between blood pressure parameters and selected measures of adiposity.

Methods: A cross-sectional, school-based study of 540 10- to14-year-old children from seven schools in the Eastern Cape Province was carried out. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5830/CVJA-2019-017DOI Listing
May 2020
5 Reads

Renal denervation: bleak past, brighter future.

Authors:
Brian Rayner

Cardiovasc J Afr 2019 Sep/Oct;30(5):249-250

Senior Scholar and Emeritus Professor, Division of Nephrology and Hypertension, Kidney and Hypertension Research Unit, University of Cape Town, Cape Town, South Africa. Email:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5830/CVJA-2019-056DOI Listing

Familial hypercholesterolaemia and its management in South Africa.

Authors:
A D Marais

Cardiovasc J Afr 2019 Sep/Oct;30(5):247-248

Chemical Pathology, Health Sciences, University of Cape Town, Observatory, South Africa. Email:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5830/CVJA-2019-054DOI Listing

The effect of beta-blockers on foetal birth weight in pregnancies in women with structural heart disease: a prospective cohort study.

Cardiovasc J Afr 2019 Nov 13;30:1-6. Epub 2019 Nov 13.

Hatter Institute for Cardiovascular Research in Africa, Department of Medicine, Faculty of Health Sciences, University of Cape Town, South Africa; Department of Cardiology, Groote Schuur Hospital, University of Cape Town, South Africa ; Mary McKillop Institute for Health Research, ACU, Melbourne, Australia. Email:

Objective: To examine whether treatment with beta-blockers (BBs) in pregnant women with structural heart disease (SHD) resulted in a decrease in foetal birth weight (FBW) in a South African cohort.

Methods: This was a prospective cohort study conducted in a tertiary-level hospital in Cape Town from 2010 to 2016. Of the 178 pregnant women with SHD, 24. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5830/CVJA-2019-061DOI Listing
November 2019

The effects of aquatic and land exercise on resting blood pressure and post-exercise hypotension response in elderly hypertensives.

Cardiovasc J Afr 2020 May/Jun 23;31(3):116-122. Epub 2019 Oct 25.

School of Physical Education, Federal University of Ouro Preto, Brazil.

Objective: This study compared resting blood pressure (BP) using ambulatory BP monitoring (ABPM) responses in two groups of subjects trained in land exercise (LE) and aquatic exercise (AE), and assessed post-exercise hypotension (PEH) using ABPM, after land- and aquatic-based exercises.

Methods: ABPM (24 hours) was used to measure the baseline BP in elderly hypertensive women trained in LE and AE and the PEH induced by exercise. For this, 40 subjects were evaluated at rest and after a land- or aquatic-based exercise session (aerobic: 75% of reserve heart rate combined with resistance exercise). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5830/CVJA-2019-051DOI Listing
October 2019

Salidroside protects the cardiac function of exhausted rats by inducing Nrf2 expression.

Cardiovasc J Afr 2020 Jan/Feb 23;31(1):25-32. Epub 2019 Oct 2.

Department of Cardiology, No. 252 Hospital of the Chinese People's Liberation Army, Baoding, Hebei, China. Email:

Objective: To investigate whether salidroside (Sal) protected the rat heart from exhaustive exercise-induced injury by inducing nuclear factor erythroid 2-related factor 2 (Nrf2) expression.

Methods: Forty-eight male Sprague-Dawley rats were divided into four groups (n = 12 rats per group): the control, the exhaustive swimming (ES) group, the low-dose Sal plus acute exhaustive swimming (SLE) group, and the high-dose Sal plus acute exhaustive swimming (SHE) group. In the SLE and SHE groups, 15 and 30 mg/kg Sal were administered, respectively, once a day. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5830/CVJA-2019-043DOI Listing
October 2019

Does acid reflux precipitate ischaemia in subjects with acute coronary syndrome?

Cardiovasc J Afr 2019 Sep 27;30:1-6. Epub 2019 Sep 27.

Department of Cardiology, Nelson R Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa. Email:

Aim: It has been postulated that gastro-oesophageal reflux disease (GORD) may trigger coronary ischaemia through viscerocardiac reflex vasoconstriction in subjects with ischaemic heart disease (IHD). Our aim was to estimate the prevalence of GORD in subjects with IHD who present with acute coronary syndrome (ACS) and to determine whether GORD may serve as a trigger for ischaemic events.

Methods: Twenty patients with isolated reflux oesophagitis and 39 with acute coronary syndrome (ACS with concomitant GORD) were studied. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5830/CVJA-2019-048DOI Listing
September 2019
6 Reads

Geographical influence on the distribution of the prevalence of hypertension in South Africa: a multilevel analysis.

Cardiovasc J Afr 2020 Jan/Feb 23;31(1):47-54. Epub 2019 Sep 20.

Department of Statistics, University of Pretoria, Pretoria, South Africa.

Background: As a response to the growing burden of non-communicable diseases, the South African government has set targets to reduce the prevalence of people with raised blood pressure, through lifestyle changes and medication, by 20% by the year 2020. It has also recognised that the prevalence varies at local administrative level. The study aim was to determine the geographical variation by district of the prevalence of hypertension among South African adults aged 15 years and above. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5830/CVJA-2019-047DOI Listing
September 2019
4 Reads