J Thorac Cardiovasc Surg 2021 May 14;161(5):e337-e347. Epub 2019 Nov 14.
Department of Anesthesiology, National Cheng Kung University Hospital and College of Medicine, Tainan, Taiwan; School of Medicine, I-Shou University College of Medicine, Kaohsiung, Taiwan; Department of Anesthesiology, E-Da Hospital and E-Da Cancer Hospital, Kaohsiung, Taiwan. Electronic address:
Objectives: Spinal cord ischemia (SCI) is one of the major concerns of postoperative paraplegia during major vascular or aortic surgery. Since mitochondrial dysfunction develops at the early stage of SCI, this study tested the neuronal protective effect of transplantation of viable mitochondria to the ischemic cord in rats.
Methods: SCI was induced by crossclamping of thoracic aorta at T6 level for 25 minutes, followed by release of vascular clip to restore aortic blood flow in the anesthetized rats. Read More