1,842,953 results match your criteria Cardiovascular & Hematological Disorders - Drug Targets [Journal]


Chronic stable heart failure model in ovine species.

Artif Organs 2020 Jul 9. Epub 2020 Jul 9.

University Department for Cardiac Surgery, Leipzig Heart Center, Leipzig, Germany.

Introduction: Establishing a chronic heart failure (HF) model is challenging, particularly in the sheep model. The aim of this study was to establish a reproducible model of HF in an ovine model.

Methods: Seventeen sheep were operated using the left thoracotomy approach. Read More

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http://dx.doi.org/10.1111/aor.13772DOI Listing

Gene expression analysis of autofluorescence margins in leukoplakia and oral carcinoma: a pilot study.

Oral Dis 2020 Jul 9. Epub 2020 Jul 9.

Department of Health Sciences, "Magna Graecia" University of Catanzaro, Catanzaro, Italy.

Objectives: Autofluorescence is considered a useful technique in the early detection of oral mucosal alterations. However, its efficacy to discriminate tumor margins is still under debate. The purpose of this pilot study was to confirm the existence of molecular divergence from the centre of a lesion compared to white light and autofluorescence (VELscope ) visualized margins in leukoplakia and oral carcinoma. Read More

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http://dx.doi.org/10.1111/odi.13525DOI Listing

Comparison between Standard Single Chamber vs Dual Chamber Low Glucose Degradation Product Peritoneal Dialysis Fluids.

Artif Organs 2020 Jul 9. Epub 2020 Jul 9.

UCL Department of Nephrology, Royal Free Hospital, University College London, London, UK.

Background: Dual chamber (DC) peritoneal dialysis (PD) dialysates contain fewer glucose degradation products (GDPs), so potentially reducing advanced glycosylation end products (AGEs), which have been reported to increase inflammation and cardiovascular risk. We wished to determine whether use of DC dialysates resulted in demonstrable patient benefits.

Methods: Biochemical profiles, body composition, muscle strength and skin autofluorescence measurements of tissue AGEs (SAF) were compared in patients using DC and standard single chamber dialysates. Read More

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http://dx.doi.org/10.1111/aor.13768DOI Listing

Cacao Bean Polyphenols Inhibit Cardiac Hypertrophy and Systolic Dysfunction in Pressure Overload-induced Heart Failure Model Mice.

Planta Med 2020 Jul 9. Epub 2020 Jul 9.

Division of Molecular Medicine, Graduate School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan.

Pathological stresses such as pressure overload and myocardial infarction induce cardiac hypertrophy, which increases the risk of heart failure. Cacao bean polyphenols have recently gained considerable attention for their beneficial effects on cardiovascular diseases. This study investigated the effect of cacao bean polyphenols on the development of cardiac hypertrophy and heart failure. Read More

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http://dx.doi.org/10.1055/a-1191-7970DOI Listing

Mortality of Patients with Cushing's Disease.

Exp Clin Endocrinol Diabetes 2020 Jul 9. Epub 2020 Jul 9.

Institute of Metabolism and Systems Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom of Great Britain and Northern Ireland.

Cushing's disease is a rare condition of cortisol excess attributed to a pituitary adenoma with an annual incidence of 1.2-2.4 cases per million population. Read More

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http://dx.doi.org/10.1055/a-1197-6380DOI Listing

Limiting factors of peak and submaximal exercise capacity in LVAD patients.

PLoS One 2020 9;15(7):e0235684. Epub 2020 Jul 9.

Department of Cardiovascular Sciences, Cardiac Surgery, Katholieke Universiteit Leuven, Leuven, Belgium.

Aims: Although patients supported with a Continuous-Flow Left Ventricular Assist Device (CF-LVAD) are hemodynamically stable, their exercise capacity is limited. Hence, the aim of this work was to investigate the underlying factors that lead to peak and submaximal exercise intolerance of CF-LVAD supported patients.

Methods: Seven months after CF-LVAD implantation, eighty three patients performed a maximal cardiopulmonary exercise test and a six minute walk test. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0235684PLOS

Dimethyl fumarate protects cardiomyocytes against oxygen-glucose deprivation/reperfusion (OGD/R)-induced inflammatory response and damages via inhibition of Egr-1.

Int Immunopharmacol 2020 Jul 6;86:106733. Epub 2020 Jul 6.

Department of Cardiovascular Surgery, People's Hospital of Zhengzhou University, Henan Provincial People's Hospital, Fuwai Central China Cardiovascular Hospital, Zhengzhou, Henan 450000, China.

Acute myocardial infarction (AMI) is associated with high rates of morbidity and mortality. Atherosclerosis is among the leading causes of AMI. The rupture or erosion of atherosclerotic plaques can obstruct coronary arteries, thereby leading to an acute inflammatory reaction to ischemic injury and cardiomyocyte apoptosis. Read More

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http://dx.doi.org/10.1016/j.intimp.2020.106733DOI Listing

GSTM3 variant is a novel genetic modifier in Brugada syndrome, a disease with risk of sudden cardiac death.

EBioMedicine 2020 Jul 6;57:102843. Epub 2020 Jul 6.

Lankenau Institute for Medical Research and Lankenau Heart Institute, Wynnewood, PA and Sidney Kimmel Medical College of Thomas Jefferson University, Philadelphia, PA, USA. Electronic address:

Background: Brugada syndrome (BrS) is a rare inherited disease causing sudden cardiac death (SCD). Copy number variants (CNVs) can contribute to disease susceptibility, but their role in Brugada syndrome (BrS) is unknown. We aimed to identify a CNV associated with BrS and elucidated its clinical implications. Read More

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http://dx.doi.org/10.1016/j.ebiom.2020.102843DOI Listing

A long RP supraventricular tachycardia with the earliest atrial activation at the His-bundle region: What is the ablation target?

Heart Rhythm 2020 Jul 6. Epub 2020 Jul 6.

Department of Cardiovascular Medicine, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo, Tokyo 113-8510, Japan.

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http://dx.doi.org/10.1016/j.hrthm.2020.06.036DOI Listing

Nationwide Comparison of the Medical Complexity of Patients by Surgical Specialty.

J Vasc Surg 2020 Jul 6. Epub 2020 Jul 6.

Division of Vascular & Endovascular Surgery, University of California Los Angeles, Los Angeles, CA, USA. Electronic address:

Objectives: Intuitively, the chronic disease burden of surgical patients varies considerably by surgical specialty, though sparse evidence in the literature supports this notion. We sought to characterize the medical complexity of surgical patients by surgical specialty and to quantify the association between medical complexity and outcomes.

Methods: The National Inpatient Sample, an all-payer inpatient database representative of 97% of all US hospitalizations, was used to identify adults undergoing surgery between 2005-14. Read More

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http://dx.doi.org/10.1016/j.jvs.2020.05.072DOI Listing

Time-dependent changes in the clinical characteristics and prognosis of hospitalized COVID-19 patients in Wuhan, China: A retrospective study.

Clin Chim Acta 2020 Jul 6. Epub 2020 Jul 6.

Department of Cardiology, Renmin Hospital of Wuhan University, China; Cardiovascular Research Institute, Wuhan University, China; Hubei Key Laboratory of Cardiology, China. Electronic address:

Cases of coronavirus disease 2019 (COVID-19) have been breaking out around the world recently. However, the dynamic changes in the clinical symptoms and prognosis of COVID-19 patients remain unknown. According to the onset time of clinical symptoms, 843 COVID-19 patients admitted between Jan 22 and Feb 14, 2020 were divided into three groups: group A (Jan 21 to Jan 25, n = 324), group B (Jan 26 to Jan 31, n = 358) and group C (Feb 1 to Feb 10, n = 161). Read More

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http://dx.doi.org/10.1016/j.cca.2020.06.051DOI Listing

Mild Exercise Does Not Prevent Atherosclerosis in APOE*3-Leiden.CETP Mice or Improve Lipoprotein Profile of Men with Obesity.

Obesity (Silver Spring) 2020 Jun 17. Epub 2020 Jun 17.

Division of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, The Netherlands.

Objective: Exercise has been shown to improve cardiometabolic health, yet neither the molecular connection nor the effects of exercise timing have been elucidated. The aim of this study was to investigate whether ad libitum or time-restricted mild exercise reduces atherosclerosis development in atherosclerosis-prone dyslipidemic APOE*3-Leiden.CETP mice and whether mild exercise training in men with obesity affects lipoprotein levels. Read More

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http://dx.doi.org/10.1002/oby.22799DOI Listing

Physical activity during and after breast cancer therapy and associations of baseline physical activity with changes in cardiac function by echocardiogram.

Cancer Med 2020 Jul 9. Epub 2020 Jul 9.

Department of Biostatistics, Epidemiology & Informatics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.

Background: Observational studies suggest that regular physical activity may reduce cardiovascular morbidity and cancer recurrence in survivors of breast cancer. The association between physical activity and cardiac function with breast cancer therapy is unknown.

Methods: Self-reported physical activity was assessed using the Godin Leisure-Time Exercise Questionnaire at repeated intervals in a longitudinal cohort study of 603 breast cancer participants treated with doxorubicin and/or trastuzumab. Read More

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http://dx.doi.org/10.1002/cam4.3277DOI Listing

Effectiveness of blood flow-restricted slow walking on mobility in severe multiple sclerosis: a pilot randomized trial.

Scand J Med Sci Sports 2020 Jul 9. Epub 2020 Jul 9.

Department of Biomedical and Surgical Specialties Sciences, Section of Sport Sciences, University of Ferrara, Via Luigi Borsari 46, 44121, Ferrara, Italy.

Objective: We tested the safety, feasibility and effectiveness of blood flow restriction-empowered low-intensity interval walking exercise (BFR-W) compared with conventional intensive overground walking (CON-W) at improving gait speed and functional capacity in patients with multiple sclerosis (MS) and severe gait disabilities.

Methods: 24 patients (58±5 years; 7 males) with progressive MS (Expanded Disability Status Scale 5.5-6. Read More

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http://dx.doi.org/10.1111/sms.13764DOI Listing

Circulating and tissue biomarkers as predictors of bromine gas inhalation.

Ann N Y Acad Sci 2020 Jul 9. Epub 2020 Jul 9.

Department of Anesthesiology and Perioperative Medicine, the University of Alabama at Birmingham, Birmingham, Alabama.

The threat from deliberate or accidental exposure to halogen gases is increasing, as is their industrial applications and use as chemical warfare agents. Biomarkers that can identify halogen exposure, diagnose victims of exposure or predict injury severity, and enable appropriate treatment are lacking. We conducted these studies to determine and validate biomarkers of bromine (Br ) toxicity and correlate the symptoms and the extent of cardiopulmonary injuries. Read More

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http://dx.doi.org/10.1111/nyas.14422DOI Listing

An Evaluation of Baseline Kidney Function in the REPRIEVE Trial of Pitavastatin in Human Immunodeficiency Virus.

J Infect Dis 2020 Jul;222(Supplement_1):S41-S51

Duke Clinical Research Institute, Duke University School of Medicine, Durham, North Carolina, USA.

Background: Chronic kidney disease is a common comorbid condition among persons living with human immunodeficiency virus (PWH). We characterized baseline kidney function in the REPRIEVE (Randomized Trial to Prevent Vascular Events in HIV) trial cohort.

Methods: REPRIEVE enrolled PWH with low to moderate cardiovascular risk based on traditional risk factors to evaluate the effect of statin therapy on cardiovascular events. Read More

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http://dx.doi.org/10.1093/infdis/jiaa222DOI Listing

Physical Function Impairment and Frailty in Middle-Aged People Living With Human Immunodeficiency Virus in the REPRIEVE Trial Ancillary Study PREPARE.

J Infect Dis 2020 Jul;222(Supplement_1):S52-S62

University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.

Background: People with human immunodeficiency virus (PWH) are at risk for accelerated development of physical function impairment and frailty; both associated with increased risk of falls, hospitalizations, and death. Identifying factors associated with physical function impairment and frailty can help target interventions.

Methods: The REPRIEVE trial enrolled participants 40-75 years of age, receiving stable antiretroviral therapy with CD4+ T-cell count >100 cells/mm3, and with low to moderate cardiovascular disease risk. Read More

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http://dx.doi.org/10.1093/infdis/jiaa249DOI Listing

Patterns of Antiretroviral Therapy Use and Immunologic Profiles at Enrollment in the REPRIEVE Trial.

J Infect Dis 2020 Jul;222(Supplement_1):S8-S19

Metabolism Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.

Background: Patterns of antiretroviral therapy (ART) use and immunologic correlates vary globally, and contemporary trends are not well described.

Methods: The REPRIEVE trial (Randomized Trial to Prevent Vascular Events in HIV) enrolled persons with human immunodeficiency virus (HIV) who were aged 40-75 years, receiving ART, and had low-to-moderate cardiovascular disease risk. ART use was summarized within Global Burden of Disease (GBD) super-regions, with adjusted linear and logistic regression analyses examining associations with immune parameters and key demographics. Read More

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http://dx.doi.org/10.1093/infdis/jiaa259DOI Listing

Leveraging a Landmark Trial of Primary Cardiovascular Disease Prevention in Human Immunodeficiency Virus: Introduction From the REPRIEVE Coprincipal Investigators.

J Infect Dis 2020 Jul;222(Supplement_1):S1-S7

Center for Biostatistics in AIDS Research, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.

The Randomized Trial to Prevent Vascular Events in HIV (REPRIEVE) is the largest study of cardiovascular disease in human immunodeficiency virus. Enrolling 7770 participants from 2015 to 2019 with sites across 5 continents, REPRIEVE will assess the effects of a statin as a cardiovascular disease prevention strategy in people with HIV (PWH) receiving antiretroviral therapy (ART). Although the primary purpose of REPRIEVE, and its substudy assessing coronary plaque, is to assess cardiovascular outcomes, the trial is a rich source of data on population characteristics and critical comorbidities in PWH, particularly across Global Burden of Disease (GBD) regions, reflective of the ethnic, racial, and gender diversity in this global epidemic. Read More

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http://dx.doi.org/10.1093/infdis/jiaa098DOI Listing

Characteristics of REPRIEVE Trial Participants Identifying Across the Transgender Spectrum.

J Infect Dis 2020 Jul;222(Supplement_1):S31-S40

National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.

Because persons who identify across the transgender spectrum (PATS) are a key population in human immunodeficiency virus (HIV) yet are underreported in HIV and cardiovascular research, we aimed to characterize this population within the REPRIEVE global clinical trial (n = 7770). Acceptance of gathering gender identity was high (96%). Participation by PATS was 1. Read More

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http://dx.doi.org/10.1093/infdis/jiaa213DOI Listing

Correlates and Timing of Reproductive Aging Transitions in a Global Cohort of Midlife Women With Human Immunodeficiency Virus: Insights From the REPRIEVE Trial.

J Infect Dis 2020 Jul;222(Supplement_1):S20-S30

Metabolism Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.

Background: Reproductive aging may contribute to cardiometabolic comorbid conditions. We integrated data on gynecologic history with levels of an ovarian reserve marker (anti-müllerian hormone [AMH)] to interrogate reproductive aging patterns and associated factors among a subset of cisgender women with human immunodeficiency virus (WWH) enrolled in the REPRIEVE trial.

Methods: A total of 1449 WWH were classified as premenopausal (n = 482) (menses within 12 months; AMH level ≥20 pg/mL; group 1), premenopausal with reduced ovarian reserve (n = 224) (menses within 12 months; AMH <20 pg/mL; group 2), or postmenopausal (n = 743) (no menses within12 months; AMH <20 pg/mL; group 3). Read More

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http://dx.doi.org/10.1093/infdis/jiaa214DOI Listing

Myocardial Steatosis Among Antiretroviral Therapy-Treated People With Human Immunodeficiency Virus Participating in the REPRIEVE Trial.

J Infect Dis 2020 Jul;222(Supplement_1):S63-S69

Metabolism Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.

Background: People with human immunodeficiency virus (PWH) face increased risks for heart failure and adverse heart failure outcomes. Myocardial steatosis predisposes to diastolic dysfunction, a heart failure precursor. We aimed to characterize myocardial steatosis and associated potential risk factors among a subset of the Randomized Trial to Prevent Vascular Events in HIV (REPRIEVE) participants. Read More

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http://dx.doi.org/10.1093/infdis/jiaa245DOI Listing

Plasma levels of growth differentiation factor 15 are associated with future risk of venous thromboembolism.

Blood 2020 Jul 9. Epub 2020 Jul 9.

K.G. Jebsen Thrombosis Research and Expertise Center (TREC), Department of Clinical Medicine, UiT - The Arctic University of Norway, Tromsø, Norway.

Growth differentiation factor 15 (GDF-15), a marker of inflammation and oxidative stress, has emerged as a biomarker for arterial cardiovascular disease. However, the association between GDF-15 and venous thromboembolism (VTE) remains uncertain. We therefore investigated the association between plasma GDF-15 levels and future risk of incident VTE, and explored the potential of a causal association using Mendelian randomization (MR). Read More

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http://dx.doi.org/10.1182/blood.2019004572DOI Listing

Multiple extremity necrosis in fatal calciphylaxis: Case report.

J Bras Nefrol 2020 Jul 8. Epub 2020 Jul 8.

Universidade Federal de São Paulo (UNIFESP), Escola Paulista de Medicina (EPM), Departamento de Medicina, São Paulo, SP, Brazil.

Introduction: The clinical impact of vascular calcification is well established in the context of cardiovascular morbidity and mortality, but other clinical syndromes, such as calciphylaxis, although less frequent, have a significant impact on chronic kidney disease.

Methods: Case report of a 27-year-old woman, who had complained of bilateral pain in her toes for 3 days, with the presence of small necrotic areas in the referred sites. She had a history of type 1 diabetes (25 years ago), with chronic kidney disease, on peritoneal dialysis, in addition to rheumatoid arthritis. Read More

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http://dx.doi.org/10.1590/2175-8239-JBN-2020-0025DOI Listing

Concerns of older patients and their caregivers in the emergency department.

PLoS One 2020 9;15(7):e0235708. Epub 2020 Jul 9.

Division of General Internal Medicine, Department of Internal Medicine, Section Acute Medicine, Maastricht University Medical Center, Maastricht University, Maastricht, The Netherlands.

Background: Older emergency department (ED) patients often have complex problems and severe illnesses with a high risk of adverse outcomes. It is likely that these older patients are troubled with concerns, which might reflect their preferences and needs concerning medical care. However, data regarding this topic are lacking. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0235708PLOS

Cardiopulmonary bypass and internal thoracic artery: Can roller or centrifugal pumps change vascular reactivity of the graft? The IPITA study: A randomized controlled clinical trial.

PLoS One 2020 9;15(7):e0235604. Epub 2020 Jul 9.

MITOVASC Institute CNRS UMR 6214, INSERM U1083, University of Angers, Angers, France.

Background: Cardiopulmonary bypass (CPB) induces a systemic inflammatory response (SIRS) and affects the organ vascular bed. Experimentally, the lack of pulsatility alters myogenic tone of resistance arteries and increases the parietal inflammatory response. The purpose of this study was to compare the vascular reactivity of the internal thoracic arteries (ITAs) due to the inflammatory response between patients undergoing coronary artery bypass grafting (CABG) under CPB with a roller pump or with a centrifugal pump. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0235604PLOS

Endosonographic finding of the simultaneous depiction of bile and pancreatic ducts can predict difficult biliary cannulation on endoscopic retrograde cholangiopancreatography.

PLoS One 2020 9;15(7):e0235757. Epub 2020 Jul 9.

Department of Prevention and Analysis of Cardiovascular Diseases, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Kagoshima, Japan.

Thus far, no curved linear array endoscopic ultrasound (CLAEUS) findings were established as predictors of difficult selective bile duct cannulation (SBDC). This study aimed to identify CLAEUS findings to predict endoscopic retrograde cholangiopancreatography (ERCP) cases with difficult SBDC. This single-center, retrospective cohort study was conducted between July 2014 and June 2017. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0235757PLOS

CT in relation to RT-PCR in diagnosing COVID-19 in The Netherlands: A prospective study.

PLoS One 2020 9;15(7):e0235844. Epub 2020 Jul 9.

Department of Internal Medicine, Division of General Internal Medicine, Section Acute Medicine, Maastricht University Medical Centre, Maastricht, The Netherlands.

Introduction: Early differentiation between emergency department (ED) patients with and without corona virus disease (COVID-19) is very important. Chest CT scan may be helpful in early diagnosing of COVID-19. We investigated the diagnostic accuracy of CT using RT-PCR for SARS-CoV-2 as reference standard and investigated reasons for discordant results between the two tests. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0235844PLOS

Evidence-based beta blocker use associated with lower heart failure readmission and mortality, but not all-cause readmission, among Medicare beneficiaries hospitalized for heart failure with reduced ejection fraction.

PLoS One 2020 9;15(7):e0233161. Epub 2020 Jul 9.

Department of Epidemiology, University of Alabama at Birmingham, Birmingham, Alabama, United States of America.

The beta blockers carvedilol, bisoprolol, and sustained-release metoprolol succinate reduce readmissions and mortality among patients with heart failure with reduced ejection fraction (HFrEF), based upon clinical trial and registry studies. Results from these studies may not generalize to the typical patient with HFrEF. We conducted a retrospective cohort study of beneficiaries in the Medicare 5% sample hospitalized for HFrEF between 2007 and 2013 and were discharged alive. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0233161PLOS

Dual anti-thrombotic treatment with direct anticoagulants improves clinical outcomes in patients with Atrial Fibrillation with ACS or undergoing PCI. A systematic review and meta-analysis.

PLoS One 2020 9;15(7):e0235511. Epub 2020 Jul 9.

Division of Cardiology, Department of Medical and Surgical Sciences, "Magna Graecia" University, Catanzaro, Italy.

Background: There is recent new evidence regarding the combined use of direct oral antiocoagulants and antiplatelet agents in patients with Atrial Fibrillation undergoing PCI.

Purpose: To compare the efficacy of dual antithrombotic treatment (DAT) including a direct oral anticoagulant (DOAC) and an antiplatelet agent versus triple antithrombotic treatment (TAT) with a vitamin K antagonist (VKA).

Data Sources: PubMed, SCOPUS and Google Scholar from through 09/09/2019; references of eligible studies; relevant scientific sessions abstracts and cardiology websites. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0235511PLOS

Modelling the effect of compliance with WHO salt recommendations on cardiovascular disease mortality and costs in Brazil.

PLoS One 2020 9;15(7):e0235514. Epub 2020 Jul 9.

Department of Global Health and Sustainability, School of Public Health, University of Sao Paulo, Sao Paulo, São Paulo, Brazil.

Introduction: Cardiovascular diseases (CVDs) represent the main cause of death among non-communicable diseases (NCDs) in Brazil, and they have a high economic impact on health systems. Most populations around the world, including Brazilians, consume excessive sodium, which increases blood pressure and the risk of CVDs.

Objective: To model the estimated deaths and costs associated with CVDs, which are mediated by increased blood pressure attributable to excessive sodium consumption in adults from the perspective of the Brazilian public health system in 2017. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0235514PLOS

One-year efficacy and safety of everolimus-eluting bioresorbable scaffolds in the setting of acute myocardial infarction.

PLoS One 2020 9;15(7):e0235673. Epub 2020 Jul 9.

Division of Cardiology, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, United States of America.

Background And Objectives: This study sought to compare clinical outcomes between bioresorbable scaffolds (BRS) and durable polymer everolimus-eluting metallic stents (DP-EES) in patients with acute myocardial infarction (AMI) undergoing successful percutaneous coronary intervention (PCI).

Methods: From March 2016 to October 2017, 952 patients with AMI without cardiogenic shock undergoing successful PCI with BRS (n = 136) or DP-EES (n = 816) were enrolled from a multicenter, observational Korea Acute Myocardial Infarction Registry.

Results: In the crude population, there was no significant difference in the 1-year rate of device-oriented composite endpoint (DOCE) and device thrombosis between the BRS and DP-EES groups (2. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0235673PLOS

Lack of sexual dimorphism in a mouse model of isoproterenol-induced cardiac dysfunction.

PLoS One 2020 9;15(7):e0232507. Epub 2020 Jul 9.

Department of Experimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota, Minneapolis, Minnesota, United States of America.

Sex-related differences in cardiovascular diseases are highly complex in humans and model-dependent in experimental laboratory animals. The objective of this work was to comprehensively investigate key sex differences in the response to acute and prolonged adrenergic stimulation in C57Bl/6NCrl mice. Cardiac function was assessed by trans-thoracic echocardiography before and after acute adrenergic stimulation (a single sub-cutaneous dose of isoproterenol 10 mg/kg) in 15 weeks old male and female C57Bl/6NCrl mice. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0232507PLOS

Clinical presentation and comorbidities of obstructive sleep apnea-COPD overlap syndrome.

PLoS One 2020 9;15(7):e0235331. Epub 2020 Jul 9.

Division of Pneumology, Geneva University Hospitals, Geneva, Switzerland.

Background: More advanced knowledge is needed on how COPD alters the clinical presentation of obstructive sleep apnea (OSA) and how the association of both diseases, known as 'overlap syndrome' (OVS), impacts on cardiovascular health.

Objective: To investigate differences between patients with OVS and those with moderate-to-severe OSA alone.

Methods: A cross-sectional study conducted in the French National Sleep Apnea Registry between January 1997 and January 2017. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0235331PLOS

Climatic influence on the risk of abdominal aortic aneurysm rupture.

Vasc Med 2020 Jul 9:1358863X20923399. Epub 2020 Jul 9.

Vascular Surgery Division, Cardiovascular Institute, Hospital Clínic, University of Barcelona, Barcelona, Spain.

Our aim is to examine the effects of climatic conditions on the incidence of ruptured abdominal aortic aneurysms (rAAA) in Catalonia, Spain. We combined clinical data from the Public Health official registries in Catalonia, Spain (HD-MBDS) of all rAAA with local climatic data obtained from the closest meteorological station (69 stations, National Meteorological Service: MeteoCat) from 2008 to 2017. We analyzed the median, maximum, minimum, and variability of atmospheric pressure (hPa) and air temperature (°C), solar irradiation (MJ/m), humidity (%), accumulated precipitation (mm), median wind, and maximum flaw direction and velocity (°, m/s), recorded on the days of events, the previous day, and mean results for 3, 7, and 30 days before, as well as seasonality. Read More

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http://dx.doi.org/10.1177/1358863X20923399DOI Listing

Case-Studies in Physiology: The exercise pressor response to indoor rock climbing.

J Appl Physiol (1985) 2020 Jul 9. Epub 2020 Jul 9.

Institute of Exercise Physiology and Respiratory Medicine, Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, United States.

Introduction: This paper assessed the blood pressure, heart rate, and mouth-pressure responses to indoor rock climbing (bouldering) and associated training exercises.

Case Presentation: Six well-trained male rock climbers (mean ± SD age = 27.7 ± 4. Read More

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http://dx.doi.org/10.1152/japplphysiol.00357.2020DOI Listing

The safety and effectiveness of on-site paramedic and allied health treatment interventions targeting the reduction of emergency department visits by long-term care patients: systematic review.

Prehosp Emerg Care 2020 Jul 9:1-18. Epub 2020 Jul 9.

Department of Emergency Medicine, University of Ottawa, Ottawa, Ontario;

IntroductionPrograms that seek to avoid emergency department (ED) visits from patients residing in long-term care facilities are increasing. We sought to identify existing programs where allied healthcare personnel are the primary providers of the intervention and, to evaluate their effectiveness and safety.MethodsWe systematically searched Medline, CINAHL and EMBASE with terms relating to long-term care, emergency services, hospitalization and allied health personnel. Read More

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http://dx.doi.org/10.1080/10903127.2020.1794084DOI Listing

Effects of Estradiol Dose and Serum Estradiol Levels on Metabolic Measures in Early and Late Postmenopausal Women in the REPLENISH Trial.

J Womens Health (Larchmt) 2020 Jul 9. Epub 2020 Jul 9.

Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.

To identify the association of estradiol (E2) dose and serum E2 levels with metabolic measures in early (<6 years) compared with late (≥10 years) postmenopausal women from the REPLENISH trial. This is a analysis of a multicenter randomized clinical trial in the United States. Four doses of TX-001HR, an oral combination of E2 and progesterone (P4), and placebo were tested. Read More

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http://dx.doi.org/10.1089/jwh.2019.8238DOI Listing

Association between CYP2C19 gene polymorphisms and lipid metabolism in Chinese patients with ischemic stroke.

J Int Med Res 2020 Jul;48(7):300060520934657

Department of Laboratory Medicine, First Affiliated Hospital of Nanchang University, Nanchang, China.

Objective: The CYP2C19 genetic variation may be involved in the development of atherosclerotic cardiovascular disease (ASCVD). Serum lipid levels are important risk factors for ASCVD, but the effect of the CYP2C19 gene on serum lipid metabolism remains unclear. This retrospective cohort study investigated the relationship between the CYP2C19 gene polymorphism and serum lipid levels in patients with ischemic stroke (IS). Read More

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http://dx.doi.org/10.1177/0300060520934657DOI Listing

Disease assimilation: The mortality impacts of fine particulate matter on immigrants to Canada.

Health Rep 2020 Jun;31(3):14-26

School of Population and Public Health, University of British Columbia, Vancouver, British Columbia.

Background: Immigrants make up 20% of the Canadian population; however, little is known about the mortality impacts of fine particulate matter (PM) air pollution on immigrants compared with non-immigrants, or about how impacts may change with duration in Canada.

Data And Methods: This study used the 2001 Canadian Census Health and Environment Cohort, a longitudinal cohort of 3.5 million individuals, of which 764,000 were classified as immigrants (foreign-born). Read More

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http://dx.doi.org/10.25318/82-003-x202000300002-engDOI Listing

Interaction between severe chronic kidney disease and acute kidney injury in predicting mortality after transcatheter aortic valve implantation: Insights from the Italian Clinical Service Project.

Catheter Cardiovasc Interv 2020 Jul 9. Epub 2020 Jul 9.

Cardiothoracic Department, ASST Spedali Civili di Brescia, Brescia, Italy.

Aims: We aim at exploring whether severe chronic kidney disease (CKD) may modify the impact of acute kidney injury (AKI) post-transcatheter aortic valve implantation (TAVI) on early, mid, and long-term mortality.

Methods And Results: The analysis included 2,733 TAVI patients from the Italian Clinical Service Project. The population was stratified in four groups according to the presence of baseline severe CKD and postprocedural AKI. Read More

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http://dx.doi.org/10.1002/ccd.28927DOI Listing

Giant cell myocarditis in an older patient - reassessing the threshold for endomyocardial biopsy.

ESC Heart Fail 2020 Jul 9. Epub 2020 Jul 9.

2nd Department of Medicine - Department of Cardiovascular Medicine, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague, Prague, Czech Republic.

Giant cell myocarditis is a rare form of autoimmune myocarditis with high morbidity and mortality that affects mainly middle-aged adults. We report a case study of a 70-year-old man on chronic immunosuppression who presented with sustained ventricular tachycardia and symptoms of acute systolic heart failure, both with poor response to standard measures. A decision to pursue endomyocardial biopsy established the diagnosis of GCM and lead to initiation of immunosuppressive therapy and a favourable outcome. Read More

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http://dx.doi.org/10.1002/ehf2.12756DOI Listing

Adults with Down syndrome challenge another paradigm: When aging no longer entails arterial hypertension.

J Clin Hypertens (Greenwich) 2020 Jul 9. Epub 2020 Jul 9.

Adult Down Syndrome Unit, Department of Internal Medicine, Hospital Universitario de La Princesa, Madrid, Spain.

The paradigmatic relationship between aging and atherosclerotic cardiovascular events does not apply to all patient populations. Though trisomy 21 (T21) and its phenotypic expression, Down syndrome (DS), are conditions that involve premature aging, the cardiovascular system of adults with DS appears to be particularly spared from this early senescence. Despite a higher prevalence of some classic cardiovascular risk factors in adults with DS than in the general population, such as dyslipidemia, obesity, or sedentarism, these individuals do not develop hypertension or suffer major cardiovascular events as they age. Read More

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http://dx.doi.org/10.1111/jch.13930DOI Listing

The Association Between Early Age-Related Hearing Loss and Brain β-Amyloid.

Laryngoscope 2020 Jul 9. Epub 2020 Jul 9.

Department of Medicine, Columbia University, New York, New York, U.S.A.

Objectives/hypothesis: To analyze the association between early audiometric age-related hearing loss and brain β-amyloid, the pathologic hallmark of Alzheimer's disease (AD).

Study Design: Cross-sectional analysis of a prospective cohort study.

Methods: A cross-sectional analysis was performed on 98 participants in a cohort study of hearing and brain biomarkers of AD. Read More

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http://dx.doi.org/10.1002/lary.28859DOI Listing
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