1,728,974 results match your criteria Cardiovascular & Hematological Disorders - Drug Targets [Journal]


A randomized, double-blind, placebo-controlled trial to assess the efficAcy and safety of Trimetazidine in patients with angina pectoris having been treated by percutaneous coronary intervention (ATPCI study): Rationale, design, and baseline characteristics.

Am Heart J 2019 Jan 15;210:98-107. Epub 2019 Jan 15.

Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Européen Georges Pompidou (HEGP), Department of Cardiology, Paris, France; Université Paris-Descartes, Paris, France; INSERM U-970, Paris, France.

Background: About 30% of angina patients have persisting symptoms despite successful revascularization and antianginal therapy. Moreover, in stable patients, percutaneous coronary intervention (PCI) does not improve survival as compared with medical therapy alone. Trimetazidine, an antianginal agent devoid of hemodynamic effect, may help reducing symptoms and improving outcomes after PCI. Read More

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http://dx.doi.org/10.1016/j.ahj.2018.12.015DOI Listing
January 2019

Atherogenic cytokines and chemokines in chronic hepatitis C are not associated with the presence of cardiovascular diseases.

Cytokine 2019 Feb 13;115:24-31. Epub 2019 Feb 13.

Faculdade de Farmácia, Laboratório de Pesquisa em Imunologia, Universidade Federal da Bahia, Brazil. Electronic address:

There appears to be an associative link between chronic hepatitis C (CHC) and cardiovascular diseases (CVDs). However, the exact nature of the relationship between CHC and CVDs has not been elucidated. We investigated the presence of CVDs and the clinical and laboratory alterations associated with these diseases in CHC patients. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10434666183048
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http://dx.doi.org/10.1016/j.cyto.2018.12.005DOI Listing
February 2019
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Fish Oil Increases Specialized Pro-resolving Lipid Mediators in PAD (The OMEGA-PAD II Trial).

J Surg Res 2019 Feb 13;238:164-174. Epub 2019 Feb 13.

Division of Vascular and Endovascular Surgery, Department of Surgery, University of California, San Francisco, California. Electronic address:

Background: N-3 polyunsaturated fatty acid (PUFA) supplementation has been associated with reduced mortality and inflammation in patients with cardiovascular disease. There are limited data on the effects of n-3 PUFA supplementation in patients with peripheral artery disease (PAD).

Materials And Methods: The OMEGA-PAD II trial was a double-blinded, randomized, placebo-controlled trial to assess the effect of 3 mo of high-dose oral n-3 PUFA supplementation on inflammation, endothelial function, and walking ability in patients with PAD. Read More

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http://dx.doi.org/10.1016/j.jss.2019.01.038DOI Listing
February 2019

Movie violence acutely affects food choices in young adults.

Eat Behav 2019 Feb 10;33:7-12. Epub 2019 Feb 10.

Nutrition Division, Department of Natural Sciences, School of Arts and Sciences, Lebanese American University, Lebanon.

Background: Extensive research has been conducted to investigate the effects of media violence on attitudes, behaviors, and cardiovascular health; however, only few studies have examined its effect on appetite, eating behavior and food preferences. Little attention has been given to understand how movie genre manipulates the physiology and the eating behavior of individuals. The present study aimed at investigating the acute effect of violence content in movies on appetite perception, heart rate and blood pressure, along with food preferences and intake in young individuals. Read More

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http://dx.doi.org/10.1016/j.eatbeh.2019.02.002DOI Listing
February 2019

Arriba por la vida Estudio (AVE): Study protocol for a standing intervention targeting postmenopausal Latinas.

Contemp Clin Trials 2019 Feb 13. Epub 2019 Feb 13.

University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, United States.

Background: Postmenopausal Latinas are a growing population group in the US who are at high risk for cardiovascular disease. Epidemiological studies have shown that excessive sitting is related to cardiovascular disease risk. Older women sit for prolonged periods and most individuals do not meet physical activity guidelines. Read More

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http://dx.doi.org/10.1016/j.cct.2019.02.004DOI Listing
February 2019

HDL cholesterol and ASCVD risk stratification: A debate.

Atherosclerosis 2019 Jan 16;283:7-12. Epub 2019 Jan 16.

McGill University Health Center/Royal Victoria Hospital Montréal, Québec, H4A 3J1, Canada. Electronic address:

This debate is designed to review the usefulness of the cholesterol mass within high-density lipoproteins (HDL-C) to predict the risk of atherosclerotic cardiovascular disease (ASCVD). PRO: There is much current confusion regarding the role of high density lipoproteins (HDLs) in atherosclerotic cardiovascular disease (ASCVD). While it is an established fact that the concentration of HDL cholesterol is a robust, independent, inverse predictor of the risk of having an ASCVD event, recent studies have questioned whether HDLs actually protect against ASCVD. Read More

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http://dx.doi.org/10.1016/j.atherosclerosis.2019.01.001DOI Listing
January 2019

Inflammatory adipocyte-derived extracellular vesicles promote leukocyte attachment to vascular endothelial cells.

Atherosclerosis 2019 Jan 24;283:19-27. Epub 2019 Jan 24.

Cardiff School of Sport and Health Sciences, Cardiff Metropolitan University, 200 Western Avenue, Cardiff, CF5 2YB, UK. Electronic address:

Background And Aims: Obesity is associated with an increased risk of cardiovascular disease, but the mechanisms involved are not completely understood. In obesity, the adipocyte microenvironment is characterised by both hypoxia and inflammation. Therefore, we sought to determine whether extracellular vesicles (EVs) derived from adipocytes in this setting might be involved in mediating cardiovascular disease, specifically by promoting leukocyte attachment to vascular endothelial cells. Read More

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http://dx.doi.org/10.1016/j.atherosclerosis.2019.01.013DOI Listing
January 2019

Amelioration of adjuvant induced arthritis in Sprague Dawley rats through modulation of inflammatory mediators by Ribes alpestre Decne.

J Ethnopharmacol 2019 Feb 13. Epub 2019 Feb 13.

Prince Abdullah Ben Khaled Celiac Disease Research Chair, Department of Pediatrics, Faculty of Medicine, King Saud University, Riyadh, Saudi Arabia.

Ethnopharmacological Relevance: Ribes alpestre Decne has been commonly used in the treatment of joint complaints.

Aim Of Study: The present study was undertaken to evaluate the antiarthritic potential of ethanolic extract and fractions of Ribes alpestre and to explore its probable mechanism of action.

Material And Methods: Complete Freunds adjuvant induced arthritis in Sprague Dawley rats was used to assess antiarthritic activity of aqueous ethanol extract, butanol and aqueous fractions at 200mg/kg oral dose for 28 days. Read More

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http://dx.doi.org/10.1016/j.jep.2019.02.025DOI Listing
February 2019

Perceptions of Canadian vascular surgeons toward pharmacologic risk reduction in patients with peripheral artery disease: 2018 update.

Ann Vasc Surg 2019 Feb 13. Epub 2019 Feb 13.

Division of Vascular Surgery, Li Ka Shing Knowledge Institute of St. Michael's Hospital, and University of Toronto, Toronto, ON, Canada; Department of Surgery, King Saud University, Riyadh, Kingdom of Saudi Arabia; King Saud University-Li Ka Shing Collaborative Research Program, Toronto, Ontario, Canada; and Riyadh, Kingdom of Saudi Arabia. Electronic address:

Background: Vascular surgeons have a central role in managing peripheral artery disease (PAD). This study assessed their knowledge, attitudes, and behaviours regarding pharmacologic risk reduction in PAD and results were compared to a similar 2004 survey conducted by our group.

Methods: An online questionnaire was administered to 161 active members of the Canadian Society for Vascular Surgery. Read More

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http://dx.doi.org/10.1016/j.avsg.2018.11.034DOI Listing
February 2019

Objective physical activity and physical performance in middle-aged and older adults.

Exp Gerontol 2019 Feb 13. Epub 2019 Feb 13.

Framingham Heart Study, Framingham, MA, USA; Department of General Internal Medicine, Boston University School of Medicine, Boston, MA, USA.

Background: Older adults may have difficulty meeting the Physical Activity (PA) Guidelines. A favorable balance between PA and sedentary time (SED) is an important determinant of physical performance in older adults. Our objective was to explore associations of PA/SED with physical performance across mid-older age in adults without overt mobility disability. Read More

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http://dx.doi.org/10.1016/j.exger.2019.02.003DOI Listing
February 2019

Response to 'Hydrochlorothiazide use and risk of nonmelanoma skin cancer: a nationwide case-control study from Denmark'.

J Am Acad Dermatol 2019 Feb 13. Epub 2019 Feb 13.

Department of Clinical Pharmacy & Toxicology, Maastricht UMC+, Maastricht, The Netherlands; CARIM School for Cardiovascular Disease, Maastricht University Medical Centre+, P.O. BOX 616 6200 MD, Maastricht, the Netherlands.

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http://dx.doi.org/10.1016/j.jaad.2019.01.087DOI Listing
February 2019

The molecular structure of an epoxide hydrolase from Trichoderma reesei in complex with urea or amide-based inhibitors.

Int J Biol Macromol 2019 Feb 13. Epub 2019 Feb 13.

Escola de Artes, Ciências e Humanidades, Universidade de São Paulo, 1000 Arlindo Bettio Avenue, 03828-000 São Paulo, Brazil. Electronic address:

Epoxide hydrolases (EHs) are enzymes involved in the metabolism of endogenous and exogenous epoxides, and the development of EH inhibitors has important applications in the medicine. In humans, EH inhibitors are being tested in the treatment of cardiovascular diseases and show potent anti-inflammatory effects. EH inhibitors are also considerate promising molecules against infectious diseases. Read More

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http://dx.doi.org/10.1016/j.ijbiomac.2019.02.070DOI Listing
February 2019

Assessment of risk of fasting during Ramadan under optimal diabetes care, in high-risk patients with diabetes and coronary heart disease through the use of FreeStyle Libre flash continuous glucose monitor (FSL-CGMS).

Diabetes Res Clin Pract 2019 Feb 13. Epub 2019 Feb 13.

Endocrine department, Dubai Hospital, United Arab Emirates.

Aim: Most of Muslims patients with diabetes and Coronary Heart Disease (CHD) elect to fast in Ramadan, but the actual risk in this subset of patients with diabetes is largely unknown. We aimed to understand the safety of fasting in CHD patients with diabetes insisting on fasting Ramadan under optimal care. We also monitored the change in biophysical and biochemical parameters of these patients before and after Ramadan. Read More

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http://dx.doi.org/10.1016/j.diabres.2019.01.038DOI Listing
February 2019

Pomolic acid reduces contractility and modulates excitation-contraction coupling in rat cardiomyocytes.

Eur J Pharmacol 2019 Feb 13. Epub 2019 Feb 13.

Laboratory of Cellular Physiology, Centre of Biophysics and Biochemistry, Venezuelan Institute for Scientific Research (IVIC), Caracas, Venezuela; Physiology and Biochemistry Research Group-PHYSIS, Department of Physiology and Biochemistry, Faculty of Medicine, University of Antioquia, Medellín, Colombia. Electronic address:

Pomolic acid (PA) isolated from Licania pittieri has hypotensive effects in rats, inhibits human platelet aggregation and elicits endothelium-dependent relaxation in rat aortic rings. The present study was designed to investigate the effects of PA on cardiomyocytes. Trabeculae and enzymatically isolated cardiomyocytes from rats were used to evaluate the concentration-dependent effects of PA on cardiac muscle tension and excitation-contraction coupling (ECC) by recording Ca transients reported with Fluo-3 and Fura-2, as well as L-type Ca currents (LTCC). Read More

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http://dx.doi.org/10.1016/j.ejphar.2019.02.016DOI Listing
February 2019

Severely Kinked Pseudocoarctation of the Aorta with Unicuspid Aortic Valve.

Ann Thorac Surg 2019 Feb 13. Epub 2019 Feb 13.

Department of Cardiovascular Surgery, Seirei Hamamatsu General Hospital, Shizuoka, Japan.

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http://dx.doi.org/10.1016/j.athoracsur.2019.01.027DOI Listing
February 2019

A pediatric case of Staphylococcus lugdunensis-induced infective endocarditis at bovine jugular vein.

Ann Thorac Surg 2019 Feb 13. Epub 2019 Feb 13.

Department of cardiovascular surgery, Mt. Fuji Shizuoka children's hospital, Shizuoka, Japan.

A 2-year-old boy underwent right ventricular outflow tract reconstruction (RVOTR) with a bovine jugular vein graft. He presented with high fever on postoperative day 6. Blood and drainage effusion cultures were all positive for S. Read More

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http://dx.doi.org/10.1016/j.athoracsur.2019.01.028DOI Listing
February 2019

Robotic Multi-vessel Endoscopic Coronary Bypass: Impact of a Beating Heart Approach with Connectors (Commentary).

Ann Thorac Surg 2019 Feb 13. Epub 2019 Feb 13.

Professor Cardiovascular Surgery, Indiana University Health, Surgery, Division of Cardiovascular Surgery, 1801 Senate Blvd. Indianapolis, IN 46202. Electronic address:

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http://dx.doi.org/10.1016/j.athoracsur.2019.01.021DOI Listing
February 2019

Would the proposed pathophysiology of the "full blast" make sense here? (Reply).

Ann Thorac Surg 2019 Feb 13. Epub 2019 Feb 13.

Division of Cardiovascular Surgery, Chiba University Hospital, 1-8-1 Inohana, Chuo-ku, Chiba, 2608677, Japan.

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http://dx.doi.org/10.1016/j.athoracsur.2019.01.024DOI Listing
February 2019

Luteolin-induced coronary arterial relaxation involves activation of the myocyte voltage-gated K channels and inward rectifier K channels.

Life Sci 2019 Feb 13. Epub 2019 Feb 13.

Department of Pharmacology, Shanxi Medical University, Xinjiannanlu 56, Taiyuan 030001, Shanxi Province, China. Electronic address:

Aims: Luteolin has been shown to be beneficial to cardiovascular tissues and organs. We aimed to study its vasospasmolytic effects against various vasoconstrictors in the isolated rat coronary arteries (RCAs) and its electrophysiological effects on K currents via voltage-gated potassium (Kv) channels and inward rectifier potassium (Kir) channels in freshly isolated rat coronary arterial smooth muscle cells (RCASMCs).

Main Methods: The vascular tone of the endothelium-denuded RCAs was recorded by a wire myograph. Read More

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http://dx.doi.org/10.1016/j.lfs.2019.02.028DOI Listing
February 2019

The cardiomyocyte "redox rheostat": Redox signalling via the AMPK-mTOR axis and regulation of gene and protein expression balancing survival and death.

J Mol Cell Cardiol 2019 Feb 13. Epub 2019 Feb 13.

School of Biological Sciences, University of Reading, Whiteknights, Reading RG6 6AS, UK; National Heart and Lung Institute (Cardiovascular Sciences), Faculty of Medicine, Flowers Building, Imperial College, SW7 2AZ, UK and Dovehouse Street, London SW3 6LY, UK.

Reactive oxygen species (ROS) play a key role in development of heart failure but, at a cellular level, their effects range from cytoprotection to induction of cell death. Understanding how this is regulated is crucial to develop novel strategies to ameliorate only the detrimental effects. Here, we revisited the fundamental hypothesis that the level of ROS per se is a key factor in the cellular response by applying different concentrations of HO to cardiomyocytes. Read More

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http://dx.doi.org/10.1016/j.yjmcc.2019.02.006DOI Listing
February 2019

Pre-existing fibroblasts of epicardial origin are the primary source of pathological fibrosis in cardiac ischemia and aging.

J Mol Cell Cardiol 2019 Feb 13. Epub 2019 Feb 13.

Aab Cardiovascular Research Institute, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA; Department of Biomedical Engineering, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA; Department of Pharmacology and Physiology, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA; Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA. Electronic address:

Serum response factor (SRF) and the SRF co-activators myocardin-related transcription factors (MRTFs) are essential for epicardium-derived progenitor cell (EPDC)-mobilization during heart development; however, the impact of developmental EPDC deficiencies on adult cardiac physiology has not been evaluated. Here, we utilize the Wilms Tumor-1 (Wt1)-Cre to delete Mrtfs or Srf in the epicardium, which reduced the number of EPDCs in the adult cardiac interstitium. Deficiencies in Wt1-lineage EPDCs prevented the development of cardiac fibrosis and diastolic dysfunction in aged mice. Read More

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http://dx.doi.org/10.1016/j.yjmcc.2019.01.015DOI Listing
February 2019

Role of the PRC2-Six1-miR-25 signaling axis in heart failure.

J Mol Cell Cardiol 2019 Feb 13. Epub 2019 Feb 13.

Cardiovascular Research Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Electronic address:

The reduced expression of cardiac sarco-endoplasmic reticulum Ca ATPase (SERCA2a) is a hallmark of heart failure. We previously showed that miR-25 is a crucial transcriptional regulator of SERCA2a in the heart. However, the precise mechanism of cardiac miR-25 regulation is largely unknown. Read More

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http://dx.doi.org/10.1016/j.yjmcc.2019.01.017DOI Listing
February 2019

Characterization of aspirin esterase activity in health and disease: in vitro and ex vivo studies.

Biochem Pharmacol 2019 Feb 13. Epub 2019 Feb 13.

Centro Cardiologico Monzino, IRCCS, Milan, Italy.

Due to its ability to irreversibly inactivate platelet cyclooxygenase, low-dose aspirin (ASA) is the most widely used antithrombotic agent. Although, studies in specific types of patients with cardiovascular disease (CVD) have shown an incomplete inhibition of platelet's cyclooxygenase, which may increase the variability in drug response. Some aspects of ASA pharmacokinetics (PK) still need further investigation. Read More

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http://dx.doi.org/10.1016/j.bcp.2019.02.014DOI Listing
February 2019

PKA phosphorylation underlies functional recruitment of sarcolemmal SK2 channels in ventricular myocytes from hypertrophic hearts.

J Physiol 2019 Feb 16. Epub 2019 Feb 16.

Dorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University, Columbus, OH, 43210.

Key Points Summary: Small-conductance Ca -activated K (SK) channels expressed in ventricular myocytes are dormant in health yet become functional in cardiac disease. SK channels are voltage independent and their gating is controlled by intracellular [Ca ] in a biphasic manner. Submicromolar [Ca ] activates the channel via constitutively-bound calmodulin, while higher [Ca ] exerts inhibitory effect during depolarization. Read More

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http://dx.doi.org/10.1113/JP277618DOI Listing
February 2019

Simultaneous Isolation of Stem and Niche Cells of Skeletal Muscle: Applicability for Aging Studies.

Methods Mol Biol 2019 Feb 16. Epub 2019 Feb 16.

Cell Biology Group, Department of Experimental and Health Sciences, Pompeu Fabra University (UPF), CIBER on Neurodegenerative Diseases (CIBERNED), Barcelona, Spain.

The maintenance of adult stem cells in their normal quiescent state depends on intrinsic factors and extrinsic signals originating from their microenvironment (also known as the stem cell niche). In skeletal muscle, its stem cells (satellite cells) lose their regenerative potential with aging, and this has been attributed, at least in part, to both age-associated changes in the satellite cells as in the niche cells, which include resident fibro-adipogenic progenitors (FAPs), macrophages, and endothelial cells, among others. To understand the regenerative decline of skeletal muscle with aging, there is a need for methods to specifically isolate stem and niche cells from resting muscle. Read More

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http://dx.doi.org/10.1007/7651_2019_210DOI Listing
February 2019

Diagnostic performance of F FDG PET in cardiac sarcoidosis: Are we getting closer to the truth?

J Nucl Cardiol 2019 Feb 15. Epub 2019 Feb 15.

Department of Cardiovascular Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA.

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http://dx.doi.org/10.1007/s12350-019-01653-8DOI Listing
February 2019

The forgotten right ventricle in cardio-oncology.

J Nucl Cardiol 2019 Feb 15. Epub 2019 Feb 15.

Division of Cardiovascular Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.

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http://dx.doi.org/10.1007/s12350-019-01602-5DOI Listing
February 2019

Is a Novel Nomogram Better Than TNM Staging at Predicting Survival in Siewert Type 2 Adenocarcinoma?

Ann Surg Oncol 2019 Feb 15. Epub 2019 Feb 15.

Department of Cardiovascular and Thoracic Surgery, Rush University Medical Center, Chicago, IL, USA.

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http://dx.doi.org/10.1245/s10434-019-07242-wDOI Listing
February 2019

A Summary of 2018 and What Lies Ahead for Dermatology and Therapy in 2019.

Dermatol Ther (Heidelb) 2019 Feb 15. Epub 2019 Feb 15.

Dermatology Centre, Salford Royal NHS Foundation Trust, Manchester NIHR BRC, University of Manchester, Manchester, UK.

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http://dx.doi.org/10.1007/s13555-019-0283-4DOI Listing
February 2019

Impact of smoking on cardiac magnetic resonance infarct characteristics and clinical outcome in patients with non-ST-elevation myocardial infarction.

Int J Cardiovasc Imaging 2019 Feb 15. Epub 2019 Feb 15.

Department of Internal Medicine/Cardiology, Heart Center Leipzig at University of Leipzig, Strümpellstr. 39, 04289, Leipzig, Germany.

Data derived from several studies suggest a better survival in smokers with acute myocardial infarction, a phenomenon referred to as the 'smoker's paradox'. We aimed to investigate the association of smoking with cardiac magnetic resonance (CMR) imaging determined infarct severity and major adverse cardiac events (MACE) defined as the occurrence of death, reinfarction, and congestive heart failure at 12 months in patients with non-ST-elevation myocardial infarction (NSTEMI) reperfused by early percutaneous coronary intervention (PCI). In this multicenter, registry study 311 NSTEMI patients underwent CMR imaging 3 (interquartile range [IQR] 2-4) days after PCI. Read More

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http://dx.doi.org/10.1007/s10554-019-01556-2DOI Listing
February 2019

N/OFQ-NOP System in Peripheral and Central Immunomodulation.

Handb Exp Pharmacol 2019 Feb 16. Epub 2019 Feb 16.

Department of Cardiovascular Sciences, Anaesthesia Critical Care and Pain Management, University of Leicester, Leicester Royal Infirmary, Leicester, UK.

Classical opioids (μ: mu, MOP; δ: delta, DOP and κ: kappa, KOP) variably affect immune function; they are immune depressants and there is good clinical evidence in the periphery. In addition, there is evidence for a central role in the control of a number of neuropathologies, e.g. Read More

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http://link.springer.com/10.1007/164_2018_203
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http://dx.doi.org/10.1007/164_2018_203DOI Listing
February 2019
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Quantification of myocardial deformation by deformable registration-based analysis of cine MRI: validation with tagged CMR.

Eur Radiol 2019 Feb 15. Epub 2019 Feb 15.

Department of Medical Imaging, University Health Network, 1 PMB-273, 585 University Avenue, Toronto, Ontario, M5G 2N2, Canada.

Objectives: To validate deformable registration algorithms (DRAs) for cine balanced steady-state free precession (bSSFP) assessment of global longitudinal strain (GLS) and global circumferential strain (GCS) using harmonic phase (HARP) cardiovascular magnetic resonance as standard of reference (SoR).

Methods: Seventeen patients and 17 volunteers underwent short axis stack and 2-/4-chamber cine bSSFP imaging with matching slice long-axis and mid-ventricular spatial modulation of magnetization (SPAMM) myocardial tagging. Inverse DRA was applied on bSSFP data for assessment of GLS and GCS while myocardial tagging was processed using HARP. Read More

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http://dx.doi.org/10.1007/s00330-019-06019-9DOI Listing
February 2019

Characteristics of visit-to-visit blood pressure variability in hemodialysis patients.

Hypertens Res 2019 Feb 15. Epub 2019 Feb 15.

Department of Endocrinology and Hypertension, Tokyo Women's Medical University, Tokyo, Japan.

Visit-to-visit blood pressure variability (VVBPV) is an independent risk factor for cardiovascular morbidity and mortality in the general population. Hemodialysis (HD) patients have a poor prognosis due to an increased prevalence of cardiovascular disease. Intradialytic hypotension is associated with excess mortality, but whether VVBPV influences mortality is still unclear in HD patients. Read More

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http://dx.doi.org/10.1038/s41440-019-0231-9DOI Listing
February 2019

T cell co-stimulation and co-inhibition in cardiovascular disease: a double-edged sword.

Nat Rev Cardiol 2019 Feb 15. Epub 2019 Feb 15.

Department of Surgery, Leiden University Medical Center, Leiden, Netherlands.

The role of inflammation in cardiovascular disease (CVD) is now widely accepted. Immune cells, including T cells, are influenced by inflammatory signals and contribute to the onset and progression of CVD. T cell activation is modulated by T cell co-stimulation and co-inhibition pathways. Read More

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http://dx.doi.org/10.1038/s41569-019-0164-7DOI Listing
February 2019

Connexin43 dephosphorylation at serine 282 is associated with connexin43-mediated cardiomyocyte apoptosis.

Cell Death Differ 2019 Feb 15. Epub 2019 Feb 15.

Department of Pharmacology, Beijing Key Laboratory of Metabolic Disturbance Related Cardiovascular Disease, School of Basic Medical Sciences, Capital Medical University, Beijing, 100069, P.R. China.

Gap junction protein connexin 43 (Cx43) plays an important role in regulating cardiomyocyte survival in addition to regulating electrical coordination. Cx43 dephosphorylation, found in severe cardiac pathologies, is thought to contribute to myocardial injury. However, the mechanisms underlying Cx43 mediation of cell survival and myocardial lesions remain unknown. Read More

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http://dx.doi.org/10.1038/s41418-019-0277-xDOI Listing
February 2019

Autoantibody against β-adrenoceptor promotes the differentiation of natural regulatory T cells from activated CD4 T cells by up-regulating AMPK-mediated fatty acid oxidation.

Cell Death Dis 2019 Feb 15;10(3):158. Epub 2019 Feb 15.

Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Capital Medical University, 100069, Beijing, China.

Therapeutic adoptive transfer of natural regulatory T cells (nTreg, CD4 CD25 Foxp3 T cells) or in vivo selective expansion of nTreg cells has been demonstrated to improve the cardiac function in various cardiovascular disease models. The differentiation of nTreg cells is mediated by catecholamines via β-adrenergic receptor (β-AR) activation. Autoantibody against β-adrenoceptor (β-AA) as a β-AR agonist is closely associated with the occurrence and deterioration of cardiac dysfunction. Read More

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http://dx.doi.org/10.1038/s41419-018-1209-2DOI Listing
February 2019

Do cardiovascular disease prevention programs in northern Sweden impact on population health? An interrupted time series analysis.

BMC Public Health 2019 Feb 15;19(1):202. Epub 2019 Feb 15.

Department of Epidemiology and Global Health, Umeå University, SE-901 87, Umeå, Sweden.

Background: Cardiovascular disease (CVD) is the main cause of morbidity and mortality in Sweden. This study aims to assess the impact of a CVD intervention implemented in 1993 in northern Sweden on the reduction of premature ischemic heart disease (IHD) morbidity and mortality in women and men during the period 1987-2013.

Methods: An ecological controlled interrupted time series design, with pre-intervention period defined as 1987-1993 and post-intervention period 1994-2013 was carried out. Read More

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http://dx.doi.org/10.1186/s12889-019-6514-xDOI Listing
February 2019

Performance of HbA1c versus oral glucose tolerance test (OGTT) as a screening tool to diagnose dysglycemic status in high-risk Thai patients.

BMC Endocr Disord 2019 Feb 15;19(1):23. Epub 2019 Feb 15.

Diabetes and Thyroid Center, Theptarin Hospital, Bangkok, Thailand.

Background: Dysglycemic status defined by prediabetes and diabetes is known to be related with future risk of diabetic complications and cardiovascular diseases. Herein, we aimed to determine the diagnostic accuracy of glycated hemoglobin (HbA1c) when compared with oral glucose tolerance test (OGTT) as a reference test in identifying dysglycemic status among high-risk Thai patients receiving care in an out-patient setting.

Methods: An 11-year retrospective cross-sectional study of high-risk Thai patients who underwent OGTT during 2007-2017 was analysed. Read More

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http://dx.doi.org/10.1186/s12902-019-0339-6DOI Listing
February 2019

Social determinants and cardiovascular disease mortality in Panama, 2012-2016.

BMC Public Health 2019 Feb 15;19(1):199. Epub 2019 Feb 15.

Gorgas Memorial Institute for Health Studies, Panama City, Panama.

Background: The aims of this study were to determine the geographic and time variation of social determinants of health (SDH) and cardiovascular disease (CVD) mortality in Panama from 2012 to 2016, and to identify which of the SDH has the strongest correlation with a socioeconomic index (SEI).

Methods: We conducted an ecological study obtaining mortality from the National Mortality Register and socioeconomic variables derived from the National Household Survey (NHS). The International Classification of Diseases 10th revision codes I20-I25 and I60-I69 were used for ischemic heart disease (IHD) and stroke, respectively. Read More

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http://dx.doi.org/10.1186/s12889-019-6508-8DOI Listing
February 2019

Comorbidities (excluding lymphoma) in Sjögren's syndrome.

Rheumatology (Oxford) 2019 Feb 15. Epub 2019 Feb 15.

Rheumatology Department, Doctor Negrín University Hospital of Gran Canaria, Gran Canaria, Spain.

The information about comorbidities (excluding lymphoma) in primary Sjögren's syndrome (pSS) is relatively scarce. Cardiovascular disease, infections, musculoskeletal conditions or malignancy are likely the most relevant comorbid conditions in pSS. Different infections (particularly oral candidal infections) and fibromyalgia are extremely frequent in the daily clinical practice. Read More

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http://dx.doi.org/10.1093/rheumatology/key329DOI Listing
February 2019

Performance Characteristics and Clinical Value of the Lipoprotein-Associated Phospholipase A2 by an Enzymatic Kinetic Method.

Authors:
Mengli Lu Liying Lv

Lab Med 2019 Feb 16. Epub 2019 Feb 16.

Clinical Laboratory, First Affiliated Hospital, Anhui Medical University, Hefei, People's Republic of China.

Objective: To analyze the performance characteristics, stability, and clinical value of lipoprotein-associated phospholipase A2 (Lp-PLA2) using an enzymatic kinetic method.

Methods: The performance characteristics included reference intervals, precision, and accuracy. We assessed Lp-PLA2 stability by comparing Lp-PLA2 changes under different conditions. Read More

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http://dx.doi.org/10.1093/labmed/lmy086DOI Listing
February 2019

Sutureless aortic valve replacement and postoperative pacemaker implantation: early implants or patients at risk?

Eur J Cardiothorac Surg 2019 Feb 15. Epub 2019 Feb 15.

Clinic for Heart and Thorax Surgery, University Hospital of Münster, Münster, Germany.

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http://dx.doi.org/10.1093/ejcts/ezz025DOI Listing
February 2019

Cardiovascular prevention starts from your mouth.

Eur Heart J 2019 Feb 15. Epub 2019 Feb 15.

National Centre for Cardiovascular Prevention and Outcomes, Institute of Cardiovascular Science, University College London, Level 2, Nomura House, 1 St Martins Le Grand, London, UK.

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http://dx.doi.org/10.1093/eurheartj/ehz060DOI Listing
February 2019

Positioning of self-expanding transcatheter valve prostheses.

Catheter Cardiovasc Interv 2019 Feb;93(3):530-531

Icahn School of Medicine at Mount Sinai, Cardiovascular Institute, Mount Sinai Hospital, New York, New York.

The anatomic interplay between aortic valve, ascending aorta, left ventricular outflow tract and peripheral vasculature play a major role in determining device related outcomes in transcatheter aortic valve replacement. Factors such as the alignment angle (prosthesis-ascending aorta), pre-dilatation, operating team experience and chronic kidney disease may play a role in valve displacement. Careful analysis of all imaging modalities while sizing and selecting a valve type, and attention to newer deployment techniques may improve outcomes. Read More

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http://dx.doi.org/10.1002/ccd.28134DOI Listing
February 2019

Impella support for chronic total occlusions angioplasty: A good start.

Catheter Cardiovasc Interv 2019 Feb;93(3):E191-E192

Department of Interventional Cardiology and Endovascular Therapeutics, Instituto Cardiovascular de Buenos Aires, Buenos Aires, Argentina.

There is limited data regarding percutaneous ventricular support in chronic total occlusion angioplasty in terms of population, procedure, and outcomes. This is the largest report to date showing promising results in terms of technical and procedural success in this highly comorbid population. This study encourages more research in the area and its use in large volume and experienced centers. Read More

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http://dx.doi.org/10.1002/ccd.28007DOI Listing
February 2019

The Aortix device: Support in a tube.

Catheter Cardiovasc Interv 2019 Feb;93(3):434-435

Interventional Cardiology, Lankenau Heart Institute, Wynnewood, Pennsylvania.

The use of percutaneous mechanical support devices is becoming more embedded within the therapeutic armamentarium for patients presenting with decompensated heart failure, cardiogenic shock, and patients undergoing high risk PCI. The Aortix device offers a new approach to percutaneous support that appears to be safe to implement and overcomes some of the drawbacks of the extant devices. Further investigation remains warranted to evaluate its ultimate utility and place among the approach to the patient in need of circulatory support. Read More

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http://dx.doi.org/10.1002/ccd.28136DOI Listing
February 2019

The exaggerated natriuresis of essential hypertension occurs independently of changes in renal medullary blood flow.

Acta Physiol (Oxf) 2019 Feb 15:e13266. Epub 2019 Feb 15.

Cardiovascular and Renal Research, Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark.

Aims: In patients with essential hypertension abnormal renal sodium handling includes exaggerated natriuresis in response to extracellular volume expansion. We tested the hypothesis that exaggerated natriuresis is associated with increases in medullary and/or cortical renal blood flow.

Methods: Patients with mild essential hypertension, but no signs of end organ damage, and control subjects were studied after four days of dietary standardization (<60 mmol Na day ) preceded in patients by a 14-days drug washout period. Read More

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http://dx.doi.org/10.1111/apha.13266DOI Listing
February 2019

The genetic basis of Turner syndrome aortopathy.

Am J Med Genet C Semin Med Genet 2019 Feb 16. Epub 2019 Feb 16.

Department of Molecular and Medical Genetics, Oregon Health & Science University, Portland, Oregon.

Our goal is to identify the genetic underpinnings of bicuspid aortic valve and aortopathy in Turner syndrome. We performed whole exome sequencing on 188 Turner syndrome study subjects from the GenTAC registry. A gene-based burden test, SKAT-O, was used to evaluate the data using bicuspid aortic valve (BAV) and aortic dimension z-scores as covariates. Read More

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http://dx.doi.org/10.1002/ajmg.c.31686DOI Listing
February 2019

Validity and reliability of lower-limb pulse-wave velocity assessments using an oscillometric technique.

Exp Physiol 2019 Feb 16. Epub 2019 Feb 16.

Department of Exercise and Sport Science, University of North Carolina, Chapel Hill, USA.

New Findings: What is the central question of this study? There is growing interest on the effects of sedentarism on central and peripheral cardiovascular health. To permit further investigation, including in larger epidemiological studies, there is a need to identify arterial health assessment tools that are valid (accurate) and reliable (precise), yet practical. What is the main finding and its importance? Lower-limb vascular health (femoral-ankle pulse-wave velocity) can be determined in a supine position with accuracy and precision using an oscillometric-based device. Read More

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http://dx.doi.org/10.1113/EP087444DOI Listing
February 2019

Improvements cardiometabolic risk factors in Latin American Amerindians (the Mapuche) with concurrent training.

Scand J Med Sci Sports 2019 Feb 15. Epub 2019 Feb 15.

Education department of La Unión city, Chile.

Our aim was to investigate the effects of 12-weeks of CT (i.e., high-intensity interval and resistance training) in Mapuche adults from Chile and in their peers of European descent. Read More

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http://dx.doi.org/10.1111/sms.13409DOI Listing
February 2019
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