1,729,040 results match your criteria Cardiovascular & Hematological Agents in Medicinal Chemistry[Journal]


Inhibition of endothelial Progenitor Cells Inhibition in the first 24 hours of an Acute Ischemic Cerebrovascular Event.

Isr Med Assoc J 2019 Feb;21(2):71-76

Department of Medicine, Padeh Medical Center, Poriya, Israel.

Background: Endothelial progenitor cells may have a role in ongoing endothelial repair. Impaired mobilization or depletion of these cells may contribute to progression of vascular disease. Our hypothesis was that endothelial progenitor cells would be suppressed in patients with acute cerebrovascular event based on our previous study that found severe endothelial dysfunction in those patients. Read More

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February 2019

Potential role of Anitschkow cells in cardiovascular disease in human and veterinary medicine: A review of the literature.

Anat Histol Embryol 2019 Feb 17. Epub 2019 Feb 17.

Department of Veterinary Sciences, University of Turin, Grugliasco, Turin, Italy.

Anitschkow cells (AC) are a peculiar type of stromal cells observed in myocardium, cardiac valves and coronary vessels wall whose origin, characterization and role remain controversial. In human heart, they represent a histological hallmark of Aschoff nodules in rheumatic fever, but they have also been observed in other myocardial pathologies. Firstly, they have been considered a myocyte-derived cells, but light microscopy, immunohistochemical and ultrastructural studies pointed out that a macrophagic/histiocytic origin cannot be excluded. Read More

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http://dx.doi.org/10.1111/ahe.12433DOI Listing
February 2019

Dynamic Piston Function of the Mitral Annulus to Assess Early Left Ventricular Diastolic Filling: A Proof of Concept Study.

Cardiol Ther 2019 Feb 16. Epub 2019 Feb 16.

Cardiovascular Medicine Division, University of Puerto Rico School of Medicine, San Juan, PR, USA.

Introduction: Early left ventricular (LV) filling has been described as an asymmetric toroidal vortex ring of blood entering the LV upon opening of the mitral valve. This phenomenon is in part responsible for cyclical changes in LV volumes during the cardiac cycle and also contributes to the apical and basal longitudinal displacements of the mitral annulus (MA). Although MA early diastolic (e') velocities have been used to assess early LV filling characteristics, accurate distinction between normal aging and pathological diastolic dysfunction (DD) might be challenging at times. Read More

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http://dx.doi.org/10.1007/s40119-019-0130-9DOI Listing
February 2019

Circulating anthocyanin metabolites mediate vascular benefits of blueberries: insights from randomized controlled trials, metabolomics, and nutrigenomics.

J Gerontol A Biol Sci Med Sci 2019 Feb 16. Epub 2019 Feb 16.

Division of Cardiology, Pulmonology, and Vascular Medicine, University Duesseldorf, Germany.

Potential health benefits of blueberries may be due to vascular effects of anthocyanins which predominantly circulate in blood as phenolic acid metabolites. We investigated which role blueberry anthocyanins and circulating metabolites play in mediating improvements in vascular function and explore potential mechanisms using metabolomics and nutrigenomics. Purified anthocyanins exerted a dose-dependent improvement of endothelial function in healthy humans, as measured by flow-mediated dilation (FMD). Read More

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http://dx.doi.org/10.1093/gerona/glz047DOI Listing
February 2019

[Infective Endocarditis in Right Ventricle( RV)-Pulmonary Artery( PA) Conduit Late after the Ross Procedure;Report of a Case].

Kyobu Geka 2019 Feb;72(2):156-159

Department of Cardiovascular Surgery, Seirei Hamamatsu General Hospital, Hamamatsu, Japan.

Ross procedure has been found to have a lower incidence of infective endocarditis compared to other aortic replacement procedure using prosthetic valves. We report a case of 25-year-old man who underwent Ross procedure for congenital aortic stenosis and regurgitation when he was 7 years old. He presented with fever and was highly suspected of infective endocarditis. Read More

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February 2019

[Surgical Repair of Stanford Type A Acute Aortic Dissection Associated with Anomalous Retroaortic Left Brachiocephalic Vein;Report of a Case].

Kyobu Geka 2019 Feb;72(2):153-155

Department of Cardiovascular Surgery, Yokohama Medical Center, Yokohama, Japan.

Anomalous retroaortic left brachiocephalic vein( ARLBV) is a rare vascular abnormaly, usually asossiated with congenital heart diseases. We present a very rare case of Stanford type A acute aortic dissection associated with ARLBV. A 70-year-old man was referred to our hospital complaining of worsening back pain and chest pain. Read More

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February 2019

[Isolated Mitral Valve Replacement was Effective in Patient with Hypertrophic Obstructive Cardiomyopathy and Concomitant Mitral Regurgitation;Report of a Case].

Kyobu Geka 2019 Feb;72(2):149-152

Department of Cardiovascular Surgery, Hokuto Hospital, Obihiro, Japan.

This report presents a case of a 68-year-old woman with hypertrophic obstructive cardiomyopathy (HOCM) and concomitant mitral regurgitation (MR). Preoperative echocardiography showed stenosis of the left ventricular outflow tract (LVOT) and systolic anterior leaflet motion (SAM) of the mitral valve. She underwent mitral valve replacement( MVR) alone, and obstruction of LVOT was successfully released. Read More

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February 2019

[Suspected Left Ventricular Pseudo-false Aneurysm of a Huge Size Combined with Sustained Ventricular Tachycardia;Report of a Case].

Kyobu Geka 2019 Feb;72(2):144-147

Department of Cardiovascular Surgery, Sendai Cardiovascular Disease Center, Sendai, Japan.

A 74-year-old man was transferred to our hospital for heart failure and ventricular tachycardia. Left ventricular aneurysm of a huge size( 6×9 cm) was found on the imaging test, and was suspected to be a pseudo-false aneurysm because of its thick wall with small orifice. Occulusion of the right coronary artery (#1) was revealed by coronary arteriography and the diskinetic aneurysm in the inferior wall was revealed by left ventriculography. Read More

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February 2019

[Surgery in Elderly Patient for Coronary Arteriovenous Fistula and Giant Coronary Artery Aneurysm Associated with Cardiac Failure;Report of a Case].

Kyobu Geka 2019 Feb;72(2):140-143

Department of Cardiovascular Surgery, Yamaguchi Prefectural Grand Medical Center, Hofu, Japan.

An 82-year-old woman visited the hospital with the chief complaint of dyspnea on light exertion. Computed tomography (CT) showed a coronary artery aneurysm and coronary arteriovenous fistulas. The pulmouary flow/systemic flow (Qp/Qs) ratio was 1. Read More

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February 2019

[Off-pump Coronary Artery Bypass Grafting in Jehovah's Witness Patient on Hemodialysis;Report of a Case].

Kyobu Geka 2019 Feb;72(2):136-139

Department of Cardiovascular Surgery, Japanese Red Cross Asahikawa Hospital, Asahikawa, Japan.

Cardiac surgery in Jehovah's witnesses is challenging due to their refusal of blood transfusion. Furthermore, dialysis patients often suffer from anemia and are also prone to bleeding. We performed offpump coronary artery bypass grafting (CABG) [OPCAB] on a Jehovah's witness male patient on hemodialysis. Read More

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February 2019

[Thoracic Aortic Stent Graft for Patent Ductus Arteriosus with Residual Shunt after Surgical Repair;Report of a Case].

Kyobu Geka 2019 Feb;72(2):133-135

Department of Cardiovascular Surgery, Seneikai Takase Clinic, Takasaki, Japan.

We report a case of a 75-year-old woman with residual shunt of patent ductus arteriosus after initial surgical repair. She was successfully treated by thoracic aortic stent graft and residual shunt disappeared. Re-surgical repair for residual shunt of patent ductus arteriosus is very invasive and challenging procedure. Read More

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February 2019

[Endovascular Repair of Traumatic Injury to the Descending Aorta and the Right Subclavian Artery;Report of a Case].

Kyobu Geka 2019 Feb;72(2):128-131

Department of Cardiovascular Surgery, Japanese Red Cross Okayama Hospital, Okayama, Japan.

A 32-year-old man leaping down from the 3rd floor of his house got injured and was transferred to our center. Pseudoaneurysm at the aortic isthmus as well as pelvic and lower limb fractures were observed by computed tomography (CT) scan. Thoracic endovascular aortic repair(TEVAR)of the thoracic aorta was performed from zone 2, followed by external skeletal fixation. Read More

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February 2019

[Successful Use of Percutaneous Left Ventricular Assist Device( Impella) and Veno Artery Extracorporeal Membrane Oxygenation( VA-ECMO) for Ischemic Cardiogenic Shock;Report of a Case].

Kyobu Geka 2019 Feb;72(2):120-123

Department of Cardiovascular Surgery, Nagoya Tokushukai General Hospital, Kasugai, Japan.

A 73-year-old male was referred to our hospital for acute congestive heart failure. His cardiac and respiratory conditions were worsening with cardiogenic shock requiring intubation. Coronary angiography revealed severe triple vessel disease, and echocardiography showed severe left ventricular dysfunction. Read More

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February 2019

[Splenic Injury during Replacement of the Thoracoabdominal Aorta].

Kyobu Geka 2019 Feb;72(2):104-107

Division of Cardiovascular Surgery, Tohoku University, Sendai, Japan.

Extraperitoneal approach is commonly employed for thoracoabdominal aortic repair via Stoney incision. It is supposedly rare to encounter abdominal visceral bleeding during that procedure. However, the spleen may spontaneously adhere to the adjacent peritoneum, which could induce incidental injury to the spleen by its anterior mobilization during extraperitoneal approach. Read More

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February 2019

[Giant Aneurysm of the Left Sinus of Valsalva Accompanied by Left Main Coronary Artery Compression, Myocardial Ischemia, Pericardial Tamponade].

Kyobu Geka 2019 Feb;72(2):99-103

Department of Cardiovascular Surgery, Yokkaichi Municipal Hospital, Yokkaichi, Japan.

Left sinus of Valsalva aneurysm(SVAn)is a very rare clinical entity. We present a 68-year-old female with left SVAn, 5 cm in diameter, compressing the left main coronary artery and causing antero-septal asynergy. She also had massive pericardial effusion, moderate to severe(grade Ⅲ)aortic regurgitation, and mitral regurgitation. Read More

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February 2019

Update on the impact of type 2 diabetes mellitus on bone metabolism and material properties.

Endocr Connect 2019 Mar;8(3):R55-R70

Department of Medicine III & Center for Healthy Aging, Technische Universität Dresden, Dresden, Germany.

The prevalence of type 2 diabetes mellitus (T2DM) is increasing worldwide, especially as a result of our aging society, high caloric intake and sedentary lifestyle. Besides the well-known complications of T2DM on the cardiovascular system, the eyes, kidneys and nerves, bone strength is also impaired in diabetic patients. Patients with T2DM have a 40-70% increased risk for fractures, despite having a normal to increased bone mineral density, suggesting that other factors besides bone quantity must account for increased bone fragility. Read More

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http://dx.doi.org/10.1530/EC-18-0456DOI Listing

Burden of non-accidental mortality attributable to ambient temperatures: a time series study in a high plateau area of southwest China.

BMJ Open 2019 Feb 15;9(2):e024708. Epub 2019 Feb 15.

Department of Preventive Medicine, Shantou University Medical College, Shantou, China.

Objective: To examine the total non-accidental mortality burden attributable to ambient temperatures and assess the effect modification of the burden by specific causes of death and individual characteristics in a high plateau area in southwest China.

Methods: Using daily mortality and meteorological data from 2009 to 2016, we applied a quasi-Poisson model combined with a distributed lag non-linear model to estimate the temperature-mortality association with the assessment of attributable fraction and number. We calculated attributable fractions and deaths with 95% empirical CIs (eCIs), that were due to cold and heat, defined as temperatures below and above the median temperature, and for mild and extreme temperatures, defined by cut-offs at the 2. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-024708DOI Listing
February 2019

Trends in surgical and catheter interventions for isolated congenital shunt lesions in the UK and Ireland.

Heart 2019 Feb 16. Epub 2019 Feb 16.

Paediatric Cardiac Surgery, Birmingham Children's Hospital, Birmingham, UK.

Objective: To evaluate time trends in the use of catheter and surgical procedures, and associated survival in isolated congenital shunt lesions.

Methods: Nationwide, retrospective observational study of the UK National Congenital Heart Disease Audit database from 2000 to 2016. Patients undergoing surgical or catheter procedures for atrial septal defect (including sinus venosus defect), patent foramen ovale, ventricular septal defect and patent arterial duct were included. Read More

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http://dx.doi.org/10.1136/heartjnl-2018-314428DOI Listing
February 2019

In vitro anti-platelet aggregation effects of fourteen fruits and vegetables.

Pak J Pharm Sci 2019 Jan;32(1):185-195

School of Chemistry and Chemical Engineering, Chongqing University, Chongqing, China.

In the present study, the anti-platelet aggregation activity of 14 vegetables and fruits was tested in vitro. The aqueous, 90% ethanol and ethyl acetate extracts, as well as concentrated juices of 14 foods (fruits and vegetables) were prepared, and the anti-platelet aggregation activity of those extracts was analyzed on a platelet aggregation analyzer in vitro with adenosine 5'-diphosphate (ADP), bovine thrombin (THR) and arachidonic acid (AA) as aggregation inducers, respectively. Aspirin (ASP) was used as the positive control. Read More

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January 2019

Isorhamnetin protects endothelial cells model CRL1730 from oxidative injury by hydrogen peroxide.

Pak J Pharm Sci 2019 Jan;32(1):131-136

College of Grain Science and Technology, Shenyang Normal University, Shenyang, Liaoning Province, China.

To explore the protective effect and mechanism of isorhamnetin against oxidative injury caused by HO to endothelial cell strain CRL1730 of human umbilical vein. HO and endothelial cell strain CRL1730 were used, as a model of injured endothelial cell. Three levels of crude drugs areorhamnetin, 22. Read More

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January 2019

Total flavone of Abelmoschl manihot L. medic exhibits protective effect against hind-limb ischemia in rat model.

Pak J Pharm Sci 2019 Jan;32(1):1-5

Department of Cardiovascular Medicine, Jiangsu Province Hospital of Traditional Chinese Medicine, The No.1 Clinical Medical College of Nanjing University of Traditional Chinese Medicine, Nanjing, Jiangsu, China.

Total flavones of Abelmoschus manihot L. Medic (TFA) is the major active component isolated from Chinese herb Abelmoschus manihot L. Medic. Read More

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January 2019

Prenatal alcohol exposure and facial morphology in a UK cohort.

Drug Alcohol Depend 2019 Feb 5;197:42-47. Epub 2019 Feb 5.

MRC Integrative Epidemiology Unit, Population Health Sciences, Oakfield House, Oakfield Grove, University of Bristol, BS8 2BN, UK; Bristol Dental School, University of Bristol, UK. Electronic address:

Background: High levels of prenatal alcohol exposure are known to cause an array of adverse outcomes including fetal alcohol syndrome (FAS); however, the effects of low to moderate exposure are less-well characterized. Previous findings suggest that differences in normal-range facial morphology may be a marker for alcohol exposure and related adverse effects.

Methods: In the Avon Longitudinal Study of Parents and Children, we tested for an association between maternal alcohol consumption and six FAS-related facial phenotypes in their offspring, using both self-report questionnaires and the maternal genotype at rs1229984 in ADH1B as measures of maternal alcohol consumption. Read More

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http://dx.doi.org/10.1016/j.drugalcdep.2018.11.031DOI Listing
February 2019

Statins for primary prevention in adults aged 75 years and older: A nationwide population-based case-control study.

Atherosclerosis 2019 Feb 2;283:28-34. Epub 2019 Feb 2.

Department of Endocrinology and Metabolism, Kyung Hee University Hospital at Gangdong, Kyung Hee University School of Medicine, Seoul, Republic of Korea. Electronic address:

Background And Aims: There is inadequate evidence to establish statin treatment for primary prevention in the elderly. This study evaluated whether statins are beneficial for primary prevention of cardiovascular disease (CVD) and all-cause death in adults aged ≥ 75 years.

Methods: A nationwide, nested case-control study was conducted in Korea. Read More

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http://dx.doi.org/10.1016/j.atherosclerosis.2019.01.030DOI Listing
February 2019

Lycopene protects against pressure overload-induced cardiac hypertrophy by attenuating oxidative stress.

J Nutr Biochem 2019 Jan 7;66:70-78. Epub 2019 Jan 7.

Department of Cardiology, the First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China; NHC Key Laboratory on Assisted Circulation (Sun Yat-Sen University), Guangzhou, China.. Electronic address:

Oxidative stress is considered an important pathogenic process of cardiac hypertrophy. Lycopene is a kind of carotenoid antioxidant that protects the cardiovascular system, so we hypothesized that lycopene might inhibit cardiac hypertrophy by attenuating oxidative stress. Phenylephrine and pressure overload were used to set up the hypertrophic models in vitro and in vivo respectively. Read More

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http://dx.doi.org/10.1016/j.jnutbio.2019.01.002DOI Listing
January 2019

Improvement in patient-reported sleep in type 2 diabetes and prediabetes participants receiving a continuous care intervention with nutritional ketosis.

Sleep Med 2019 Jan 3;55:92-99. Epub 2019 Jan 3.

Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, MA, USA; Division of Sleep Medicine, Harvard Medical School, Boston, MA, USA; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA. Electronic address:

Objective: Sleep disruption is frequently associated with type 2 diabetes (T2D) and hyperglycemia. We recently reported the effectiveness of a continuous care intervention (CCI) emphasizing nutritional ketosis for improving HbA1c, body weight and cardiovascular risk factors in T2D patients. The present study assessed the effect of this CCI approach on sleep quality using a subjective patient-reported sleep questionnaire. Read More

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http://dx.doi.org/10.1016/j.sleep.2018.12.014DOI Listing
January 2019

Late mortality and causes of death among 5-year survivors of childhood cancer diagnosed in the period 1960-1999 and registered in the Italian Off-Therapy Registry.

Eur J Cancer 2019 Feb 14;110:86-97. Epub 2019 Feb 14.

Epidemiology and Biostatistics Unit, IRCCS Istituto Giannina Gaslini, Genova, Italy. Electronic address:

Introduction: Advances in paediatric oncology led to the increase in long-term survival, revealing the burden of therapy-related long-term side effects. We evaluated overall and cause-specific mortality in a large cohort of Italian childhood cancer survivors (CCSs) and adolescent cancer survivors identified through the off-therapy registry.

Materials And Methods: CCSs alive 5 years after cancer diagnosis occurring between 1960 and 1999 were eligible; the last follow-up was between 2011 and 2014. Read More

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http://dx.doi.org/10.1016/j.ejca.2018.12.021DOI Listing
February 2019

Investigation on the effect of alkyl chain linked mono-thioureas as Jack bean urease inhibitors, SAR, pharmacokinetics ADMET parameters and molecular docking studies.

Bioorg Chem 2019 Feb 8;86:473-481. Epub 2019 Feb 8.

Department of Biological Sciences, College of Natural Sciences, Kongju National University, 56 Gongjudehak-Ro, Gongju, Chungnam 314-701, Republic of Korea.

The increasing resistance of pathogens to common antibiotics, as well as the need to control urease activity to improve the yield of soil nitrogen fertilization in agricultural applications, has stimulated the development of novel classes of molecules that target urease as an enzyme. In this context, the newly developed compounds on the basis of 1-heptanoyl-3-arylthiourea family were evaluated for Jack bean urease enzyme inhibition activity to validate their role as potent inhibitors of this enzyme. 1-Heptanoyl-3-arylthioureas were obtained in excellent yield and characterized through spectral and elemental analysis. Read More

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http://dx.doi.org/10.1016/j.bioorg.2019.02.011DOI Listing
February 2019

H NMR-based metabolomic analysis of nine organophosphate flame retardants metabolic disturbance in Hep G2 cell line.

Sci Total Environ 2019 Feb 4;665:162-170. Epub 2019 Feb 4.

Key Laboratory of Microbial Technology for Industrial Pollution Control of Zhejiang Province, College of Environment, Zhejiang University of Technology, Hangzhou, Zhejiang 310032, China. Electronic address:

Organophosphate flame retardants (OPFRs) are frequently found in the environment and could be adversely affecting organisms. In fact, nine OPFRs have been shown to cause endocrine disruptions, but information on the metabolism-perturbing properties of these OPFRs remains unclear. In this study, the H-nuclear magnetic resonance (NMR) based metabolomic method was applied to evaluate the metabolic disturbances caused by these nine OPFRs. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2019.02.055DOI Listing
February 2019

Patient-Reported Triggers of Paroxysmal Atrial Fibrillation.

Heart Rhythm 2019 Jan 30. Epub 2019 Jan 30.

Division of Cardiology; University of California, San Francisco; San Francisco, CA. Electronic address:

Background: Triggers for discrete atrial fibrillation (AF) events remain poorly studied and incompletely characterized.

Objective: The present study describes common triggers for AF and their relationships with patient characteristics.

Methods: We invited symptomatic, paroxysmal AF patients enrolled in the Health eHeart Study and through the patient-centered advocacy organization StopAfib. Read More

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http://dx.doi.org/10.1016/j.hrthm.2019.01.027DOI Listing
January 2019

Stenosis and revascularization of the coronary artery are associated with outcomes in presumed cardiogenic arrest survivors: a multi-center retrospective cohort study.

Resuscitation 2019 Feb 14. Epub 2019 Feb 14.

Department of Emergency Medicine, National Taiwan University Medical College and Hospital, Taipei, Taiwan. Electronic address:

Background: The emergent coronary angiography (CAG) is associated with better outcomes in CA survivors. However, the impact of severity and revascularization of coronary artery stenosis on outcomes in cardiac arrest (CA) survivors remains unclear.

Methods: A total of 273 non-traumatic adult CA survivors who underwent emergent CAG from January 2011 to July 2017 were retrospectively recruited. Read More

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http://dx.doi.org/10.1016/j.resuscitation.2019.01.040DOI Listing
February 2019

UBC9 regulates cardiac sodium channel Na1.5 ubiquitination, degradation and sodium current density.

J Mol Cell Cardiol 2019 Feb 14. Epub 2019 Feb 14.

Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology and Center for Human Genome Research, Huazhong University of Science and Technology, Wuhan, Hubei 430074, PR China; Department of Cardiovascular and Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA; Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH 44195, USA; Department of Genetics and Genome Sciences, Case Western Reserve University, Cleveland, OH 44106, USA. Electronic address:

Voltage-gated sodium channel Na1.5 is critical for generation and conduction of cardiac action potentials. Mutations and expression level changes of Na1. Read More

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http://dx.doi.org/10.1016/j.yjmcc.2019.02.007DOI Listing
February 2019

Relaxin and fibrosis: Emerging targets, challenges, and future directions.

Mol Cell Endocrinol 2019 Feb 14. Epub 2019 Feb 14.

Cardiovascular Disease Theme, Monash Biomedicine Discovery Institute and Department of Pharmacology, Monash University, Clayton, VIC, Australia; Central Clinical School, Monash University, Prahran, VIC, Australia. Electronic address:

The peptide hormone relaxin is well-known for its anti-fibrotic actions in several organs, particularly from numerous studies conducted in animals. Acting through its cognate G protein-coupled receptor, relaxin family peptide receptor 1 (RXFP1), serelaxin (recombinant human relaxin) has been shown to consistently inhibit the excessive extracellular matrix production (fibrosis) that results from the aberrant wound-healing response to tissue injury and/or chronic inflammation, and at multiple levels. Furthermore, it can reduce established scarring by promoting the degradation of aberrant extracellular matrix components. Read More

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http://dx.doi.org/10.1016/j.mce.2019.02.005DOI Listing
February 2019

The Circle of Life: Vieussens' Arterial Ring.

JACC Cardiovasc Interv 2019 Feb 7. Epub 2019 Feb 7.

Division of Cardiovascular Medicine, University of Nebraska Medical Center, Omaha, Nebraska. Electronic address:

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http://dx.doi.org/10.1016/j.jcin.2018.12.016DOI Listing
February 2019

"Rescue" LAMPOON to Treat Transcatheter Mitral Valve Replacement-Associated Left Ventricular Outflow Tract Obstruction.

JACC Cardiovasc Interv 2019 Feb 7. Epub 2019 Feb 7.

Sussex Cardiac Centre, Royal Sussex County Hospital, Brighton, United Kingdom.

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http://dx.doi.org/10.1016/j.jcin.2018.12.026DOI Listing
February 2019

Is Transcarotid an "Alternative" Access?

JACC Cardiovasc Interv 2019 Feb 7. Epub 2019 Feb 7.

Department of Cardiology, Houston Methodist Hospital, Houston, Texas.

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http://dx.doi.org/10.1016/j.jcin.2018.11.022DOI Listing
February 2019

SLC22A3 is associated with lipoprotein (a) concentration and cardiovascular disease in familial hypercholesterolemia.

Clin Biochem 2019 Feb 14. Epub 2019 Feb 14.

Lipids, Nutrition and Cardiovascular Prevention Clinic, Montreal Clinical Research Institute, Québec, Canada; Department of Medicine, Division of Experimental Medicine, McGill University, Québec, Canada; Department of Medicine, Division of Medical Biochemistry, McGill University, Québec, Canada. Electronic address:

Background And Aims: Several clinical and genetic factors have been shown to modulate the cardiovascular risk in subjects affected by familial hypercholesterolemia (FH). Genome wide association studies (GWAS) in the general population have identified several single nucleotide polymorphisms (SNPs) significantly associated with the risk of cardiovascular disease (CVD). This include the rs2048327 variant in the SLC22A3 gene. Read More

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http://dx.doi.org/10.1016/j.clinbiochem.2019.02.008DOI Listing
February 2019

Ten-year follow-up of unreplaced Valsalva sinuses after aortic valve replacement in bicuspid aortic valve disease.

Arch Cardiovasc Dis 2019 Feb 13. Epub 2019 Feb 13.

Department of Cardiovascular Surgery, Georges Pompidou European Hospital, AP-HP, 75015 Paris, France; School of Medicine, Paris Descartes University, Sorbonne Paris Cité, 75006 Paris, France.

Background: Aortopathy is common in patients with bicuspid aortic valve (BAV).

Aim: To evaluate the fate of unreplaced Valsalva sinuses in patients with BAV, 10 years after aortic valve replacement (AVR) with or without replacement of the ascending aorta (RAA).

Methods: We retrospectively reviewed all surgical patients with BAV who were operated on between January 2005 and December 2007. Read More

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http://dx.doi.org/10.1016/j.acvd.2018.11.014DOI Listing
February 2019

Low starting-dosage of nintedanib for the reduction of early termination.

Respir Investig 2019 Feb 13. Epub 2019 Feb 13.

Kanagawa Cardiovascular and Respiratory Center, Department of Respiratory Medicine, Tomioka-Higashi 6-16-1, Kanazawa-ku, Yokohama 236-0051, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.resinv.2018.12.010DOI Listing
February 2019

Pnpla3 silencing with antisense oligonucleotides ameliorates nonalcoholic steatohepatitis and fibrosis in Pnpla3 I148M knock-in mice.

Mol Metab 2019 Feb 5. Epub 2019 Feb 5.

Department of Molecular and Clinical Medicine, University of Gothenburg, Sweden; Clinical Nutrition Unit, Department of Medical and Surgical Sciences, Magna Graecia University, Catanzaro, Italy; Cardiology Department, Sahlgrenska University Hospital, Gothenburg, Sweden. Electronic address:

Objective: Nonalcoholic fatty liver disease (NAFLD) is becoming a leading cause of advanced chronic liver disease. The progression of NAFLD, including nonalcoholic steatohepatitis (NASH), has a strong genetic component, and the most robust contributor is the patatin-like phospholipase domain-containing 3 (PNPLA3) rs738409 encoding the 148M protein sequence variant. We hypothesized that suppressing the expression of the PNPLA3 148M mutant protein would exert a beneficial effect on the entire spectrum of NAFLD. Read More

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http://dx.doi.org/10.1016/j.molmet.2019.01.013DOI Listing
February 2019

Additional Prognostic Value of 2D Right Ventricular Speckle-Tracking Strain for Prediction of Survival in Heart Failure and Reduced Ejection Fraction: A Comparative Study With Cardiac Magnetic Resonance.

JACC Cardiovasc Imaging 2019 Feb 11. Epub 2019 Feb 11.

Division of Cardiology, Department of Cardiovascular Diseases, Cliniques Universitaires St. Luc, Brussels, Belgium; and Pôle de Recherche Cardiovasculaire, Institut de Recherche Expérimentale et Clinique, Université Catholique de Louvain, Brussels, Belgium. Electronic address:

Objectives: This study sought to compare the prognostic value of 2-dimensional (2D) right ventricular (RV) speckle tracking (STE) against cardiac magnetic resonance (CMR) RV ejection fraction (EF) and feature tracking (FT) and conventional echocardiographic parameters on overall and cardiovascular (CV) survival in patients with heart failure with reduced EF (HFrEF).

Background: Prior works showed that RV systolic function predicts prognosis in HFrEF. 2D RVSTE had recently been proposed as new echocardiographic method to evaluate RV dysfunction. Read More

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http://dx.doi.org/10.1016/j.jcmg.2018.11.028DOI Listing
February 2019

Automated Pixel-Wise Quantitative Myocardial Perfusion Mapping by CMR to Detect Obstructive Coronary Artery Disease and Coronary Microvascular Dysfunction: Validation Against Invasive Coronary Physiology.

JACC Cardiovasc Imaging 2019 Feb 11. Epub 2019 Feb 11.

Royal Free Hospital, London, United Kingdom; Division of Medicine, University College London, United Kingdom. Electronic address:

Objectives: The study sought to assess the performance of cardiovascular magnetic resonance (CMR) myocardial perfusion mapping against invasive coronary physiology reference standards for detecting coronary artery disease (CAD, defined by fractional flow reserve [FFR] ≤0.80), microvascular dysfunction (MVD) (defined by index of microcirculatory resistance [IMR] ≥25) and the ability to differentiate between the two.

Background: Differentiation of epicardial (CAD) and MVD in patients with stable angina remains challenging. Read More

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http://dx.doi.org/10.1016/j.jcmg.2018.12.022DOI Listing
February 2019

Mechanism of Abnormal Septal Motion in Left Bundle Branch Block: Role of Left Ventricular Wall Interactions and Myocardial Scar.

JACC Cardiovasc Imaging 2019 Feb 11. Epub 2019 Feb 11.

Institute for Surgical Research, Oslo University Hospital and University of Oslo, Oslo, Norway; Center for Cardiological Innovation, Oslo University Hospital, Oslo, Norway; Department of Cardiology, Oslo University Hospital, Oslo, Norway; Institute of Clinical Medicine, University of Oslo, Oslo, Norway. Electronic address:

Objectives: This study sought to investigate how regional left ventricular (LV) function modifies septal motion in left bundle branch block (LBBB).

Background: In LBBB, the interventricular septum often has marked pre-ejection shortening, followed by immediate relengthening (rebound stretch). This motion, often referred to as septal flash, is associated with positive response to cardiac resynchronization therapy (CRT). Read More

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http://dx.doi.org/10.1016/j.jcmg.2018.11.030DOI Listing
February 2019

Detecting Coronary Inflammation With Perivascular Fat Attenuation Imaging: Making Sense From Perivascular Attenuation Maps.

JACC Cardiovasc Imaging 2019 Feb 11. Epub 2019 Feb 11.

Department of Cardiology, Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom; Caristo Diagnostics, Oxford, United Kingdom.

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http://dx.doi.org/10.1016/j.jcmg.2018.12.024DOI Listing
February 2019

Relationship Between Focal and Diffuse Fibrosis Assessed by CMR and Clinical Outcomes in Heart Failure With Preserved Ejection Fraction.

JACC Cardiovasc Imaging 2019 Feb 11. Epub 2019 Feb 11.

Department of Cardiovascular Sciences, University of Leicester, National Institute for Health Research, Leicester Biomedical Research Centre, Leicester, United Kingdom.

Objectives: This study sought to assess the presence and extent of focal and diffuse fibrosis in heart failure in patients with preserved ejection fraction (HFpEF) compared to asymptomatic control subjects, and the relationship of fibrosis to clinical outcome.

Background: Myocardial fibrosis has been implicated in the pathophysiology of HFpEF.

Methods: In this prospective, observational study, 140 subjects of similar age and sex (HFpEF: n = 96; control subjects: n = 44; 73 ± 8 years of age; 49% males) underwent cardiac magnetic resonance imaging. Read More

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http://dx.doi.org/10.1016/j.jcmg.2018.11.031DOI Listing
February 2019

Peri-Coronary Adipose Tissue Density Is Associated With F-Sodium Fluoride Coronary Uptake in Stable Patients With High-Risk Plaques.

JACC Cardiovasc Imaging 2019 Feb 11. Epub 2019 Feb 11.

Department of Imaging (Division of Nuclear Medicine), Medicine, and Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, California. Electronic address:

Objectives: This study aimed to assess the association between increased lesion peri-coronary adipose tissue (PCAT) density and coronary F-sodium fluoride (F-NaF) uptake on positron emission tomography (PET) in stable patients with high-risk coronary plaques (HRPs) shown on coronary computed tomography angiography (CTA).

Background: Coronary F-NaF uptake reflects the rate of calcification of coronary atherosclerotic plaque. Increased PCAT density is associated with vascular inflammation. Read More

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http://dx.doi.org/10.1016/j.jcmg.2018.11.032DOI Listing
February 2019

Prognostic Role of Cardiac MRI and Conventional Risk Factors in Myocardial Infarction With Nonobstructed Coronary Arteries.

JACC Cardiovasc Imaging 2019 Feb 11. Epub 2019 Feb 11.

Bristol Heart Institute, University Hospitals Bristol NHS Foundation Trust, Bristol, United Kingdom; School of Clinical Sciences, Faculty of Health Sciences, University of Bristol, Bristol, United Kingdom; Bristol National Institute of Health Research, Biomedical Research Centre, Bristol, United Kingdom. Electronic address:

Objectives: This study sought to assess the prognostic impact of cardiovascular magnetic resonance (CMR) and conventional risk factors in patients with myocardial infarction with nonobstructed coronaries (MINOCA).

Background: Myocardial infarction with nonobstructed coronary arteries (MINOCA) represents a diagnostic dilemma, and the prognostic markers have not been clarified.

Methods: A total of 388 consecutive patients with MINOCA undergoing cardiac magnetic resonance (CMR) assessment were identified retrospectively from a registry database and prospectively followed for a primary clinical endpoint of all-cause mortality. Read More

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http://dx.doi.org/10.1016/j.jcmg.2018.12.023DOI Listing
February 2019

Velocities of Naturally Occurring Myocardial Shear Waves Increase With Age and in Cardiac Amyloidosis.

JACC Cardiovasc Imaging 2019 Feb 11. Epub 2019 Feb 11.

Department of Cardiovascular Science, Division of Cardiology, University Hospital Leuven, University of Leuven, Leuven, Belgium. Electronic address:

Objectives: This study sought to evaluate whether velocity of naturally occurring myocardial shear waves (SW) could relate to myocardial stiffness (MS) in vivo.

Background: Cardiac SW imaging has been proposed as a noninvasive tool to assess MS. SWs occur after mechanical excitation of the myocardium (e. Read More

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http://dx.doi.org/10.1016/j.jcmg.2018.11.029DOI Listing
February 2019

Long-Term Outcomes After Aortic Valve Surgery in Patients With Asymptomatic Chronic Aortic Regurgitation and Preserved LVEF: Impact of Baseline and Follow-Up Global Longitudinal Strain.

JACC Cardiovasc Imaging 2019 Feb 11. Epub 2019 Feb 11.

Valve Center, Department of Cardiovascular Medicine, Heart and Vascular Institute, Cleveland Clinic, Cleveland, Ohio. Electronic address:

Objectives: This study sought to determine whether baseline left ventricular global longitudinal strain (LV-GLS) and changes in left ventricular ejection fraction (LVEF) in a subgroup of subjects at post-operative follow-up added prognostic value in patients undergoing aortic valve (AV) surgery.

Background: In patients with chronic severe aortic regurgitation (AR) and preserved LVEF, sensitive markers are needed to decide timing of AV surgery.

Methods: This was an observational study in 865 patients (asymptomatic/mildly symptomatic, 52 ± 15 years of age, 79% men) with ≥3+ chronic AR and preserved LVEF of ≥50% who underwent AV surgery between 2003 and 2015. Read More

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http://dx.doi.org/10.1016/j.jcmg.2018.12.021DOI Listing
February 2019

Reproducibility of semi-automated three-dimensional volumetric analysis using cardiac computed tomography in patients with left ventricular assist device.

Cardiovasc Revasc Med 2019 Jan 23. Epub 2019 Jan 23.

MedStar Washington Hospital Center, Washington, D.C., United States of America; MedStar Cardiovascular Research Network, Washington, D.C., United States of America. Electronic address:

Background: Multi-detector gated cardiac computed tomography (CCT) allows three-dimensional (3D) quantification of cardiac chambers and is clinically indicated to assess left ventricular assist device (LVAD) malfunction and complications. Automated volumetric analysis is, however, disrupted by inflow cannula artifact in patients with LVAD. With this study, we evaluated intra-observer variability in semi-automated 3D cardiac volumetric analysis using CCT in patients with LVADs. Read More

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http://dx.doi.org/10.1016/j.carrev.2019.01.024DOI Listing
January 2019

Cardiovascular effects and risks of recreational alpine skiing in the elderly.

J Sci Med Sport 2019 Jan 31. Epub 2019 Jan 31.

Department of Cardiology, University Heart Center, University of Zurich, University Hospital Zurich, Switzerland. Electronic address:

Objectives: Alpine skiing is one of the most popular recreational winter sports and attracts millions of tourists every year alone in the Alpine region. Several studies highlight the positive effects of alpine skiing as aerobic physical training and isometric muscle activity that is able to increase exercise capacity and reduce cardiovascular risk factors. However, a certain cardiovascular risk mainly related to an abrupt increase of myocardial oxygen consumption during skiing especially in otherwise sedentary subjects and effects of hypoxia in untrained patients have to be acknowledged. Read More

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http://dx.doi.org/10.1016/j.jsams.2019.01.016DOI Listing
January 2019
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