1,743,360 results match your criteria Cardiovascular & Hematological Agents in Medicinal Chemistry[Journal]


Spontaneous Aortocaval Fistula with Abdominal Aortic Aneurysm 5 Years after Aortic Valve Replacement Complicated by Aortic Dissection.

Aorta (Stamford) 2018 Dec 24;6(6):145-146. Epub 2019 Apr 24.

Department of Cardiovascular and Thoracic Surgery, Medical University of Tunis, Rabta Hospital, Tunis, Tunisia.

Iatrogenic aortic dissection after cardiac surgery is a rare and serious complication, the management of which involves many therapeutic modalities and whose prognosis is associated with high rate of morbidity and mortality. The authors report the case of a 61-year-old man presented with aortocaval fistula and aortic dissection 5 years after aortic valve replacement. Read More

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http://dx.doi.org/10.1055/s-0039-1683882DOI Listing
December 2018

Spontaneous Early Resolution of an Iatrogenic Type A Aortic Dissection Following Coronary Angiography.

Aorta (Stamford) 2018 Dec 24;6(6):142-144. Epub 2019 Apr 24.

Department of Anesthesiology, Erzurum Regional Training and Research Hospital, Erzurum, Turkey.

A 74-year-old man was admitted with the diagnosis of non-ST-elevation myocardial infarction. During right coronary angiography, a coronary artery dissection extending into the proximal ascending aorta was noticed without hemodynamic compromise. Immediate computed tomography angiography showed no evidence of dissection in the ascending aorta. Read More

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http://dx.doi.org/10.1055/s-0039-1683956DOI Listing
December 2018

Case Report of an Infrequent Complication of Infective Endocarditis: The Complete Detachment from the Aorta of the Previous Vein Graft Anastomosis.

Aorta (Stamford) 2018 Dec 24;6(6):139-141. Epub 2019 Apr 24.

Department of Cardiovascular Surgery, Ramon y Cajal Hospital, Madrid, Spain.

The authors report an unusual complication of acute infective endocarditis found in a 70-year-old man with a previous history of two cardiac surgery procedures. During median sternotomy, a massive bleeding occurred. The bleeding was contained within the mediastinum and originated from the 10-year-old anastomosis of the saphenous vein to a composite graft, which was completely detached due to infective endocarditis of the aortic graft. Read More

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http://dx.doi.org/10.1055/s-0039-1678554DOI Listing
December 2018

Head and Neck Pain in Patients Presenting with Acute Aortic Dissection.

Aorta (Stamford) 2018 Dec 24;6(6):130-138. Epub 2019 Apr 24.

Department of Internal Medicine, University of Michigan Health System, Ann Arbor, Michigan.

Background:  Head and neck pain is an atypical presentation of acute aortic dissection. Classic teaching associates this pain with proximal dissections, but this has not been extensively studied.

Methods:  Patients enrolled in the International Registry of Acute Aortic Dissection from January 1996 to March 2015 were included in this study. Read More

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http://dx.doi.org/10.1055/s-0039-18388DOI Listing
December 2018

Higher urinary cortisol levels associated with increased cardiovascular risk.

Endocr Connect 2019 Apr 1. Epub 2019 Apr 1.

G Williams, Medicine/Endocrinology, Brigham and Women's Hospital, Boston, 02115, United States.

There is conflicting data on whether variations of physiologic cortisol levels associate with cardiovascular risk. We hypothesize that prior discordant findings are related to problems associated with varying sample size, techniques for assessing cardiovascular risk, and failure to adequately account for environmental factors. We utilized a large sample size, selected the Framingham risk score to compute cardiovascular risk, and performed the study in a highly controlled setting. Read More

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http://dx.doi.org/10.1530/EC-19-0182DOI Listing

Geriatric Polytrauma-Cardiovascular and Immunologic Response in a Murine Two-Hit Model of Trauma.

J Surg Res 2019 Apr 21;241:87-94. Epub 2019 Apr 21.

Department of Orthopaedic Trauma, RWTH Aachen University, Aachen, Germany.

Background: The aims of the present study were to establish a clinically relevant two-hit model with trauma/hemorrhage followed by sepsis in older mice and investigate age-dependent cardiovascular and immunologic specificities under these conditions.

Materials And Methods: In aged mice (12, 18, and 24 mo old), a femur fracture followed by hemorrhage was induced. After resuscitation, animals were monitored for 72 h before sepsis was induced. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00224804193016
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http://dx.doi.org/10.1016/j.jss.2019.03.053DOI Listing
April 2019
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Practical considerations for developmental thyroid toxicity assessments: What's working, what's not, and how can we do better?

Regul Toxicol Pharmacol 2019 Apr 21. Epub 2019 Apr 21.

BASF SE, Experimental Toxicology and Ecology, 67056, Ludwigshafen, Germany. Electronic address:

Thyroid hormones (THs; T3 and T4) play a role in development of cardiovascular, reproductive, immune and nervous systems. Thus, interpretation of TH changes from rodent studies (during pregnancy, in fetuses, neonates, and adults) is critical in hazard characterization and risk assessment. A roundtable session at the 2017 Society of Toxicology (SOT) meeting brought together academic, industry and government scientists to share knowledge and different perspectives on technical and data interpretation issues. Read More

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http://dx.doi.org/10.1016/j.yrtph.2019.04.010DOI Listing

Cardiovascular Risk Reduction with Icosapent Ethyl. Reply.

N Engl J Med 2019 04;380(17):1678

University of Maryland School of Medicine, Baltimore, MD.

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http://dx.doi.org/10.1056/NEJMc1902165DOI Listing

Cardiovascular Risk Reduction with Icosapent Ethyl.

N Engl J Med 2019 04;380(17):1678

University of Bologna, Bologna, Italy

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http://dx.doi.org/10.1056/NEJMc1902165DOI Listing

Cardiovascular Risk Reduction with Icosapent Ethyl.

N Engl J Med 2019 04;380(17):1677

University of Washington School of Pharmacy, Seattle, WA

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http://dx.doi.org/10.1056/NEJMc1902165DOI Listing

Home as a Place for Care of the Oldest Stroke Patients: A Pilot from the Catalan Stroke Program.

J Am Geriatr Soc 2019 Apr 24. Epub 2019 Apr 24.

Stroke Program, Ministry of Health of Catalonia, Barcelona, Spain.

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http://dx.doi.org/10.1111/jgs.15944DOI Listing

Correlates of hospitalizations in internal medicine divisions among Israeli adults of different ethnic groups with hypertension, diabetes and cardiovascular diseases.

PLoS One 2019 24;14(4):e0215639. Epub 2019 Apr 24.

Department of Epidemiology and Preventive Medicine, School of Public Health, Sackler Faculty of Medicine, Tel Aviv University, Ramat Aviv, Tel Aviv, Israel.

Background: Disparities in non-communicable diseases (NCDs) may affect health care utilization. We compared the correlates of hospitalizations in internal medicine divisions, of adults with NCDs, between the main population groups in Israel.

Methods: A cross-sectional study was conducted among Jews (N = 17,952) and Arabs (N = 10,441) aged ≥40 years with diabetes, hypertension or cardiovascular diseases, utilizing the computerized database of the largest health maintenance organization in Israel. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215639PLOS

Inherited risk plus prenatal insult caused malignant dysfunction in mesenteric arteries in adolescent SHR offspring.

PLoS One 2019 24;14(4):e0215994. Epub 2019 Apr 24.

Institute for Fetology, First Hospital of Soochow University, Suzhou, Jiangsu, China.

Prenatal hypoxia can induce cardiovascular diseases in the offspring. This study determined whether and how prenatal hypoxia may cause malignant hypertension and impaired vascular functions in spontaneous hypertension rat (SHR) offspring at adolescent stage. Pregnant SHR were placed in a hypoxic chamber (11% O2) or normal environment (21% O2) from gestational day 6 until birth. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215994PLOS

Total cholesterol variability and risk of atrial fibrillation: A nationwide population-based cohort study.

PLoS One 2019 24;14(4):e0215687. Epub 2019 Apr 24.

Division of Endocrinology and Metabolism, Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea.

Background: Long-term variability of cardiometabolic risk factors have been suggested as the risk factors for cardiovascular disease and mortality. However, the effect of long-term variability of total cholesterol (TC) on incident atrial fibrillation (AF) has not been examined.

Methods And Findings: We explored whether visit-to-visit TC variability are associated with the risk of incident AF in 160,165 Korean adults, using the population-based Korean National Health Insurance Service-Health Screening Cohort (NHIS-HEALS) database, over a median duration of 8. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215687PLOS

Mental and physical health effects of meaningful work and rewarding family responsibilities.

PLoS One 2019 24;14(4):e0214916. Epub 2019 Apr 24.

Department of Public Health, University of Copenhagen. Copenhagen, Denmark.

Positive feelings about work and family responsibilities benefit psychological well-being, but their physical health effects remain unexplored. The study assessed whether meaningful work and reward from taking care of family benefitted physical health to the same degree as mental health. Participants were 181 Danes aged 49-51. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0214916PLOS

The match-play sprint performance of elite senior hurlers during competitive games.

PLoS One 2019 24;14(4):e0215156. Epub 2019 Apr 24.

Faculty of Health and Science, Department of Science and Technology, University of Suffolk, Ipswich, United Kingdom.

The typical sprint profile in elite hurling has yet to be established. The purpose of this study was to investigate the sprinting demands of elite hurling competition and characterize the sprinting patterns of different playing positions. GPS (10-Hz, STATSports Viper) were used to collect data from 51 hurlers during 18 games. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215156PLOS

Ion Channels and Vascular Diseases.

Arterioscler Thromb Vasc Biol 2019 May;39(5):e146-e156

From the Key Lab of Medical Electrophysiology of Ministry of Education and Medical Electrophysiological Key Lab of Sichuan Province, Institute of Cardiovascular Research, Southwest Medical University, Luzhou, China (J.C., J.W., N.W., Q.X., Y.Y.).

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http://dx.doi.org/10.1161/ATVBAHA.119.312004DOI Listing

Revealing the Origins of Foam Cells in Atherosclerotic Lesions.

Arterioscler Thromb Vasc Biol 2019 May;39(5):836-838

From the Robert M. Berne Cardiovascular Research Center (K.M.O., G.F.A., G.K.O.), University of Virginia, Charlottesville.

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http://dx.doi.org/10.1161/ATVBAHA.119.312557DOI Listing

Mechanisms of Sex Differences in Exercise Capacity.

Am J Physiol Regul Integr Comp Physiol 2019 Apr 24. Epub 2019 Apr 24.

Cardiovascular Research Institute, Department of Cell Biology and Molecular Medicine, Rutgers University-New Jersey Medical School, United States.

Sex differences are an important component of NIH rigor. The goal of this investigation was to test the hypothesis that female mice have greater exercise capacity than male mice, and that it is due to estrogen, nitric oxide, and myosin heavy chain expression. Female C57BL6/J wild-type mice exhibited greater, p<0. Read More

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http://dx.doi.org/10.1152/ajpregu.00394.2018DOI Listing

Identification of Novel Phospholipid Transfer Protein Inhibitors by High-Throughput Screening.

SLAS Discov 2019 Apr 24:2472555219842210. Epub 2019 Apr 24.

1 Biological/Pharmacological Research Laboratories, Central Pharmaceutical Research Institute, Japan Tobacco Inc., Takatsuki, Osaka, Japan.

Atherogenesis has been recognized as a risk factor for lethal cardiovascular diseases. Plasma low-density lipoprotein levels are correlated to the occurrence of atherosclerosis, and their control is critical for both the prevention and treatment of these diseases. Phospholipid transfer protein (PLTP) is one of the key regulators of lipoprotein metabolism; PLTP-deficient mice exhibit decreased apolipoprotein B (apoB)-containing lipoprotein secretion and atherosclerosis, indicating the validity of PLTP as a promising therapeutic target. Read More

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http://dx.doi.org/10.1177/2472555219842210DOI Listing

Current Paradigms and New Perspectives on Fetal Hypoxia: Implications for Fetal Brain Development in Late Gestation.

Am J Physiol Regul Integr Comp Physiol 2019 Apr 24. Epub 2019 Apr 24.

Pharmacodynamics, University of Florida, United States.

The availability of oxygen to the fetus is limited by the route taken by oxygen from atmosphere to fetal tissues, aided or diminished by pregnancy-associated changes in maternal physiology, and ultimately a function of atmospheric pressure and composition of the mother's inspired gas. Much of our understanding of the fetal physiological response to hypoxia comes from experiments designed to elucidate the cardiovascular and endocrine responses to transient hypoxia. Complementing this work is equally impactful research into the origins of intrauterine growth restriction, using animal models designed to restrict the transfer of oxygen from maternal to fetal circulation. Read More

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http://dx.doi.org/10.1152/ajpregu.00008.2019DOI Listing

Comprehensive Study of the Proteome and Transcriptome of the Venom of the Most Venomous European Viper: Discovery of a New Subclass of Ancestral Snake Venom Metalloproteinase Precursor-Derived Proteins.

J Proteome Res 2019 Apr 24. Epub 2019 Apr 24.

Department of Molecular and Biomedical Sciences , Jožef Stefan Institute , Jamova cesta 39 , SI-1000 Ljubljana , Slovenia.

The nose-horned viper, its nominotypical subspecies Vipera ammodytes ammodytes ( Vaa), in particular, is, medically, one of the most relevant snakes in Europe. The local and systemic clinical manifestations of poisoning by the venom of this snake are the result of the pathophysiological effects inflicted by enzymatic and nonenzymatic venom components acting, most prominently, on the blood, cardiovascular, and nerve systems. This venom is a very complex mixture of pharmacologically active proteins and peptides. Read More

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http://dx.doi.org/10.1021/acs.jproteome.9b00120DOI Listing

Osteogenic circulating endothelial progenitor cells are linked to electrocardiographic conduction abnormalities in rheumatic patients.

Ann Noninvasive Electrocardiol 2019 Apr 24:e12651. Epub 2019 Apr 24.

Cardiology Division, Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong SAR, China.

Background: Osteogenic circulating endothelial progenitor cells (EPC) play a pathogenic role in cardiovascular system degeneration through promulgating vasculature calcification, but its role in conduction disorders as part of the cardiovascular degenerative continuum remained unknown.

Aim: To investigate the role of osteocalcin (OCN)-expressing circulating EPCs in cardiac conduction disorders in the unique clinical sample of rheumatoid arthritis (RA) susceptible to both abnormal bone metabolism and cardiac conduction disorders.

Methods: We performed flow cytometry studies in 134 consecutive asymptomatic patients with rheumatoid arthritis to derive osteogenic circulating OCN-positive (OCN+) CD34+KDR+ vs. Read More

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http://dx.doi.org/10.1111/anec.12651DOI Listing

Downregulation of miRNA-30a enhanced autophagy in osthole-alleviated myocardium ischemia/reperfusion injury.

J Cell Physiol 2019 Apr 24. Epub 2019 Apr 24.

Department of Cardiovascular Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan, China.

Osthole could alleviate myocardial ischemia/reperfusion (I/R) injury. However, the underlying mechanism remains unclear. In this study, we explored whether microRNA (miR)-30a and its target autophagy marker Beclin-1 involved in the osthole protective role in the rat and cells myocardial I/R injury models. Read More

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http://dx.doi.org/10.1002/jcp.28556DOI Listing

Association of Rivaroxaban With Thromboembolic Events in Patients With Heart Failure, Coronary Disease, and Sinus Rhythm: A Post Hoc Analysis of the COMMANDER HF Trial.

JAMA Cardiol 2019 Apr 24. Epub 2019 Apr 24.

Universite de Lorraine, INSERM Unite 1116, Vandoeuvre les Nancy, France.

Importance: Whether anticoagulation benefits patients with heart failure (HF) in sinus rhythm is uncertain. The COMMANDER HF randomized clinical trial evaluated the effects of adding low-dose rivaroxaban to antiplatelet therapy in patients with recent worsening of chronic HF with reduced ejection fraction, coronary artery disease (CAD), and sinus rhythm. Although the primary end point of all-cause mortality, myocardial infarction, or stroke did not differ between rivaroxaban and placebo, there were numerical advantages favoring rivaroxaban for myocardial infarction and stroke. Read More

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http://dx.doi.org/10.1001/jamacardio.2019.1049DOI Listing

Evaluation and Treatment of Patients With Bradycardia and Cardiac Conduction Delay.

JAMA Cardiol 2019 Apr 24. Epub 2019 Apr 24.

Department of Cardiovascular Disease, Mayo Clinic, Jacksonville, Florida.

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http://dx.doi.org/10.1001/jamacardio.2019.1069DOI Listing

Antithrombotic Therapy in Heart Failure-The Clot Thickens.

Authors:
Marvin A Konstam

JAMA Cardiol 2019 Apr 24. Epub 2019 Apr 24.

The CardioVascular Center, Tufts Medical Center, Boston, Massachusetts.

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http://dx.doi.org/10.1001/jamacardio.2019.1108DOI Listing

Outcomes of Percutaneous Coronary Intervention and Coronary Artery Bypass Graft Surgery for Multivessel Coronary Artery Disease: Toward Patient-Centric Decision Making.

JAMA Cardiol 2019 Apr 24. Epub 2019 Apr 24.

New York Presbyterian Hospital, Columbia University Medical Center, Cardiovascular Research Foundation, New York, New York.

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http://dx.doi.org/10.1001/jamacardio.2019.1073DOI Listing

Addition of Vitamin B Complex to Prime Solution in Cobalamin-Deficient Patients to Prevent Postoperative Delirium.

Heart Surg Forum 2019 Feb 25;22(2):E082-E087. Epub 2019 Feb 25.

Cardiovascular Surgery Department, Medicine Faculty, Bozok University, Yozgat, Turkey.

Objective: In this study, we investigated whether the addition of vitamin B complex to prime solution for cardiopulmonary bypass (CPB) in cobalamin-deficient patients undergoing on-pump coronary artery bypass grafting (CABG) helps prevent the development of postoperative delirium (POD).

Materials And Methods: In the present study, 69 of 138 patients with serum vitamin B12 levels <200 pg/mL based on the blood sample taken within 1 week prior to on-pump CABG between January 2013 and December 2017 were enrolled. The control group included 69 patients. Read More

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http://dx.doi.org/10.1532/hsf.2171DOI Listing
February 2019

Pentraxin-3 vs C-reactive protein and other prognostic biomarkers in acute coronary syndrome: A substudy of the Platelet Inhibition and Patients Outcomes (PLATO) trial.

Eur Heart J Acute Cardiovasc Care 2019 Apr 24:2048872619846334. Epub 2019 Apr 24.

7 Department of Medical Sciences, Cardiology Uppsala University, Sweden.

Aims: We investigated the dynamics, associations with patient characteristics, other biomarkers, and clinical outcomes of pentraxin 3 in acute coronary syndrome.

Methods And Results: In multivariate analyses, pentraxin 3 measured in 5154 patients randomised in the Platelet Inhibition and Patients Outcomes (PLATO) trial (NCT00391872) was compared with leukocytes, high-sensitivity C-reactive protein, interleukin-6, cystatin C, N-terminal prohormone brain natriuretic peptide, high-sensitivity troponin T and growth differentiation factor 15 concerning prediction of clinical outcome. Pentraxin 3 peaked earlier than high-sensitivity C-reactive protein and was more strongly correlated with N-terminal prohormone brain natriuretic peptide and high-sensitivity troponin T than with high-sensitivity C-reactive protein. Read More

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http://dx.doi.org/10.1177/2048872619846334DOI Listing

Post-reperfusion plasma endothelial activation markers are associated with acute kidney injury after lung transplantation.

Am J Transplant 2019 Apr 24. Epub 2019 Apr 24.

Pulmonary, Allergy, and Critical Care Division, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.

Acute kidney injury (AKI) is common after lung transplantation, but molecular markers remain poorly studied. The endothelial activation markers soluble thrombomodulin (sTM), protein C, and plasminogen activator inhibitor-1 (PAI-1) are implicated in kidney microcirculatory injury in animal models of AKI. We tested the association of 6-hour post-reperfusion plasma levels of these markers with post-transplant AKI severity in patients enrolled in the Lung Transplant Outcomes Group prospective cohort study at the University of Pennsylvania during two eras: 2004-06 (n=61) and 2013-15 (n=67). Read More

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http://dx.doi.org/10.1111/ajt.15402DOI Listing

Radiation-induced sensitivity of tissue-resident mesenchymal stem cells in the head and neck region.

Head Neck 2019 Apr 24. Epub 2019 Apr 24.

Department of Otorhinolaryngology, Klinikum der Universitaet Muenchen, Ludwig-Maximilians-Universitaet Muenchen, Munich, Germany.

Background: Tissue-resident mesenchymal stem cells (MSCs) possess the ability to migrate to areas of inflammation and promote the regeneration of damaged tissue. However, it remains unclear how radiation influences this capacity of MSC in the head and neck region.

Methods: Two types of MSCs of the head and neck region (mucosa [mMSC] and parotid gland [pMSC]) were isolated, cultured and exposed to single radiation dosages of 2 Gy/day up to 10 days. Read More

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http://dx.doi.org/10.1002/hed.25768DOI Listing

Correlating Infant Faecal Microbiota Composition and Human Milk Oligosaccharide Consumption by Microbiota of One-Month Old Breastfed Infants.

Mol Nutr Food Res 2019 Apr 24:e1801214. Epub 2019 Apr 24.

K. Borewicz, H. Smidt, Laboratory of Microbiology, Wageningen University & Research, Stippeneng 4, 6708 WE, Wageningen, the Netherlands.

Scope: Understanding biological functions of different free human milk oligosaccharides (HMOs) in shaping gastrointestinal tract microbiota during infancy is of great interest. We examined a link between HMOs in maternal milk and infant faecal microbiota composition and investigated the role of microbiota in degrading HMOs within the GI tract of healthy, breastfed, one-month old infants.

Methods And Results: Maternal breast milk and corresponding infant faeces originated from the KOALA Birth Cohort. Read More

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http://dx.doi.org/10.1002/mnfr.201801214DOI Listing

Single-session double valve replacement: TAVI+tricuspid valve-in-valve procedures.

J Card Surg 2019 Apr 24. Epub 2019 Apr 24.

Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran.

We describe a 70-year-old lady with rheumatic heart disease and a history of the mitral valve and tricuspid valve replacement, who underwent transcatheter aortic valve implantation and the tricuspid valve-in-valve procedure in a single session. Read More

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http://dx.doi.org/10.1111/jocs.14061DOI Listing

Surgical resection of enlarged calcification formed by idiopathic localized constrictive pericarditis during total aortic arch replacement for aortic dissection.

J Card Surg 2019 Apr 24. Epub 2019 Apr 24.

Department of Cardiovascular Surgery, University of Tsukuba, Ibaraki, Japan.

A 75-year-old woman presented at a prior hospital with persistent cough and was treated conservatively for a thrombosed-type aortic dissection (Stanford A). One-year after discharge, follow-up computerized tomography revealed a DeBakey type II, chronic dissecting aortic aneurysm enlarged to 54 mm. She was referred to our hospital with slight edema in the face and extremities and chest radiography showed calcification around the heart. Read More

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http://dx.doi.org/10.1111/jocs.14056DOI Listing

The impact of concurrent HIV and type II diabetes on immune maturation, immune regulation and immune activation.

APMIS 2019 Apr 24. Epub 2019 Apr 24.

Viro-Immunology Research Unit, Department of Infectious Diseases, Rigshospitalet, University Hospital of Copenhagen, 2100 Kbh Ø, Copenhagen, Denmark.

Tingstedt JL, Hove-Skovsgaard M, Gaardbo J, Ullum H, Nielsen SD, Gelpi M. The impact of concurrent HIV and type II diabetes on immune maturation, immune regulation and immune activation. Chronic immune activation and inflammation are constant findings in people living with HIV (PLWH) and contribute to the risk of non-AIDS-related morbidities, including cardiovascular diseases (CVD). Read More

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http://dx.doi.org/10.1111/apm.12956DOI Listing

The role of ministernotomy in aortic valve surgery-A prospective randomized study.

J Card Surg 2019 Apr 24. Epub 2019 Apr 24.

Department of Cardiac Surgery, Dedinje Cardiovascular Institute, Belgrade, Serbia.

Background And Aims: The purpose of this prospective randomized study was to compare the early and midterm outcomes of aortic valve replacement (AVR) through upper ministernotomy with conventional AVR through median sternotomy.

Methods: One hundred patients undergoing elective AVR were randomized into two groups: the M group (upper ministernotomy group, n = 50) and the C group (conventional sternotomy group, n = 50). The operative data, major adverse outcomes, and postoperative variables were compared between the two groups of patients. Read More

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http://dx.doi.org/10.1111/jocs.14053DOI Listing

Extracorporeal membrane oxygenation after pulmonary endarterectomy for chronic thromboembolic pulmonary hypertension.

J Card Surg 2019 Apr 24. Epub 2019 Apr 24.

Department of Cardiovascular Surgery, Tokyo Medical University, Tokyo, Japan.

Background: Pulmonary endarterectomy (PEA) is the treatment of choice for chronic thromboembolic pulmonary hypertension (CTEPH) but can result in respiratory and cardiac complications that may require extracorporeal membrane oxygenation (ECMO). We reviewed our experience with ECMO in patients undergoing PEA.

Methods And Results: Between January 2012 and August 2015, 35 patients underwent PEA for CTEPH. Read More

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http://dx.doi.org/10.1111/jocs.14052DOI Listing

Unmet medical needs in Intermittent Claudicantion with Diabetes and Coronary Artery Disease - a 'real-world' analysis on 21,197 PAD patients.

Clin Cardiol 2019 Apr 24. Epub 2019 Apr 24.

Division of Vascular Medicine, Department of Cardiology I - Coronary and Peripheral Vascular Disease, Heart Failure Medicine, University Hospital Muenster, Cardiol, Muenster, Germany.

Background: Peripheral artery disease (PAD) is frequently co-prevalent with coronary artery disease (CAD) and diabetes (DM). The study aims to define the burden of CAD and/ or DM in PAD patients at moderate stages and further to evaluate its impact on therapy and outcome.

Methods: Study is based on health insurance claims data of the BARMER reflecting an unselected "real-world" scenario. Read More

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http://dx.doi.org/10.1002/clc.23186DOI Listing

Heart rate responses to different temperatures in juvenile Poppiana dentata ( ).

Braz J Biol 2019 Apr 18. Epub 2019 Apr 18.

Department of Life Sciences, Faculty of Science and Technology, The University of the West Indies - UWI, St. Augustine, Trinidad and Tobago, West Indies.

Temperature is one of the main factors that influences cardiovascular functioning in ectotherms. Hence this study sought to investigate heart rate responses of a freshwater crab species, Poppiana dentata, to different temperature exposures since the species generally reside in habitats of fluctuating physicochemistry. Heart rates were non-invasively determined in juvenile crabs for three temperature regimes, each over an 8-day session; A: temperature exposures of 26 °C (2 days) to 30 °C (3 days) to 26 °C (3 days), B: 26 °C (2 days) to 32 °C (3 days) to 26 °C (3 days) and C: a control at constant 26 °C. Read More

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http://dx.doi.org/10.1590/1519-6984.188457DOI Listing

Basal Tryptase Levels Can Predict Clinical Severity in Hymenoptera Venom Anaphylaxis and Ischemic Cardiovascular Disorders.

J Investig Allergol Clin Immunol 2019 Apr;29(2):162-164

Department of Allergology and Immunology, ASST Grande Ospedale Metropolitano Niguarda, Milan, Italy.

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http://dx.doi.org/10.18176/jiaci.0363DOI Listing

Cathepsin S Promotes the Development of Pulmonary Arterial Hypertension.

Am J Physiol Lung Cell Mol Physiol 2019 Apr 24. Epub 2019 Apr 24.

Respiratory Therapy, Chang Gung University College of Medicine, Taiwan.

Cysteine cathepsin proteases play critical roles in cardiovascular disease progression and are implicated in extracellular matrix (ECM) degradation. Patients with pulmonary arterial hypertension (PAH) exhibit increased elastase production by pulmonary arterial smooth muscle cells (PASMCs), which is related to the degradation of elastic fibers and pulmonary vascular remodeling. However, the mechanism by which cathepsins regulate the ECM and PASMC proliferation in PAH remains unclear. Read More

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https://www.physiology.org/doi/10.1152/ajplung.00530.2018
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http://dx.doi.org/10.1152/ajplung.00530.2018DOI Listing
April 2019
1 Read

Repair of Tricuspid Valve with Pulmonary Valve Replacement in Repaired Tetralogy of Fallot.

Scand Cardiovasc J 2019 Apr 24:1-18. Epub 2019 Apr 24.

b Department of Thoracic and Cardiovascular Surgery , Samsung Medical Center, Sungkyunkwan University School of Medicine , Seoul , Korea.

Objectives: We aimed to investigate the outcome of tricuspid valve repair (TVR) performed concomitantly with pulmonary valve replacement in repaired tetralogy of Fallot (TOF) patients.

Design: This retrospective study included all patients who underwent pulmonary vale replacement from 2000 to 2016 after TOF correction. TVR patient data were compared to those of patients who underwent pulmonary vale replacement alone. Read More

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http://dx.doi.org/10.1080/14017431.2019.1610572DOI Listing

Outcomes of open heart surgery in patients with endstage renal disease.

Kidney Res Clin Pract 2019 Apr 24;38(1). Epub 2019 Apr 24.

Division of Nephrology, Department of Internal Medicine, Kyungpook National University School of Medicine, Daegu, Korea.

Background: Cardiovascular diseases of chronic dialysis patients are often undertreated because of their higher surgical risk. This study aimed to assess mortality and morbidity after open heart surgery in chronic dialysis patients compared to those with normal renal function and identify risk factors for postoperative outcomes.

Methods: We retrospectively analyzed 2,432 patients who underwent open heart surgery from 2002 to 2017 and collected data from 116 patients (38 patients on dialysis and 78 age-, sex-, and diabetes mellitus status-matched control patients with normal kidney function). Read More

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http://dx.doi.org/10.23876/j.krcp.18.0123DOI Listing

[Influence of valve height on the opening/closure performance of transplanted aortic valve].

Sheng Wu Yi Xue Gong Cheng Xue Za Zhi 2019 Apr;36(2):199-205

Department of Cardiovascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, P.R.China.

Valve transplantation is often used in the treatment of aortic valve insufficiency. However, after surgery, the reconstructed aortic roots have an expansion phenomenon, in which the lack of valve height causes the aortic valve to close again. In this paper, the effects of different aortic valve height design on valve opening and closing performance were studied. Read More

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http://dx.doi.org/10.7507/1001-5515.201709061DOI Listing

Association of Newly Developed Right Bundle Branch Block with Graft Rejection Following Heart Transplantation.

Yonsei Med J 2019 May;60(5):423-428

Division of Cardiology, Severance Cardiovascular Hospital, Cardiovascular Research Institute, Yonsei University College of Medicine, Seoul, Korea.

Purpose: We aimed to examine associations between right bundle branch block (RBBB) following heart transplantation (HT) and graft rejection.

Materials And Methods: We investigated 51 patients who underwent endomyocardial biopsies, electrocardiogram, right-side cardiac catheterization, and echocardiography at 1 month and 1 year after HT. We classified patients into four groups according to the development of RBBB, based on electrocardiogram at 1 month and 1 year: 1) sustained RBBB, 2) disappeared RBBB, 3) newly developed RBBB, and 4) sustained non-RBBB. Read More

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http://dx.doi.org/10.3349/ymj.2019.60.5.423DOI Listing

Muscle wasting and function after muscle activation and early protocol-based physiotherapy: an explorative trial.

J Cachexia Sarcopenia Muscle 2019 Apr 23. Epub 2019 Apr 23.

Department of Anesthesiology and Operative Intensive Care Medicine (CCM, CVK), Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.

Background: Early mobilization improves physical independency of critically ill patients at hospital discharge in a general intensive care unit (ICU)-cohort. We aimed to investigate clinical and molecular benefits or detriments of early mobilization and muscle activating measures in a high-risk ICU-acquired weakness cohort.

Methods: Fifty patients with a SOFA score ≥9 within 72 h after ICU admission were randomized to muscle activating measures such as neuromuscular electrical stimulation or whole-body vibration in addition to early protocol-based physiotherapy (intervention) or early protocol-based physiotherapy alone (control). Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/jcsm.12428
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http://dx.doi.org/10.1002/jcsm.12428DOI Listing
April 2019
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Altered vascular function in chronic kidney disease: evidence from passive leg movement.

Physiol Rep 2019 Apr;7(8):e14075

Department of Kinesiology and Applied Physiology, University of Delaware, Newark, Delaware.

Chronic kidney disease (CKD) is an independent risk factor for the development of cardiovascular disease and is characterized by reduced nitric oxide (NO) bioavailability and vascular dysfunction, typically assessed using brachial artery flow-mediated dilation (FMD). It has been previously reported that passive leg movement (PLM)-induced hyperemia, an assessment of lower extremity vascular function, is highly dependent on NO, but has not yet been utilized to assess vascular function in patients with CKD. The purpose of this study was to comprehensively assess vascular function in patients with CKD using PLM, in addition to the traditional FMD technique. Read More

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http://dx.doi.org/10.14814/phy2.14075DOI Listing

Maximal exercise and erythrocyte fatty-acid status: a lipidomics study.

Physiol Rep 2019 Apr;7(8):e14040

Experimental and Clinical Research Center (ECRC), A Joint Institution of the Charité Medical Faculty and Max Delbrück Center (MDC) for Molecular Medicine, Berlin, Germany.

Omega-3 fatty acids have long been ascribed a positive cardiovascular function. However, the plasma measurements invariably ignore 40% of the blood specimen, cells that engage in continuous exchange with their environment. In our study, we included all components of the circulating blood. Read More

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http://dx.doi.org/10.14814/phy2.14040DOI Listing

Nobiletin exhibits potent inhibition on tumor necrosis factor alpha-induced calcification of human aortic valve interstitial cells via targeting ABCG2 and AKR1B1.

Phytother Res 2019 Apr 23. Epub 2019 Apr 23.

Department of Cardiovascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Inflammation is considered to be one of the initial critical factors in the occurrence of calcific heart valve disease. This study was to prove Nobiletin (NBT) inhibits inflammation-caused calcification of human valve interstitial cells (hVICs) and to elucidate the involved molecular mechanisms. Tumor necrosis factor-alpha (TNF-α)-induced hVICs were treated with or without NBT. Read More

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http://dx.doi.org/10.1002/ptr.6360DOI Listing
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