282 results match your criteria Cardiorenal medicine[Journal]


De novo Cardiac Valve Calcification after Hemodialysis in End-Stage Renal Disease Patients Predicts Future Cardiovascular Events: A Longitudinal Cohort Study.

Cardiorenal Med 2019 Apr 17;9(4):229-239. Epub 2019 Apr 17.

Renal Division, Department of Internal Medicine, Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China,

Background: Cardiac valve calcification (CVC) in maintenance hemodialysis patients is associated with adverse cardiovascular outcomes. However, whether de novo CVC in incident hemodialysis patients predicts future cardiovascular events is unknown.

Methods: This study included 174 patients newly receiving hemodialysis without CVC as reflected by echocardiography between January 2005 and December 2014. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000494701DOI Listing
April 2019
4 Reads

Survival Advantage of African American Dialysis Patients with End-Stage Renal Disease Causes Related to APOL1.

Cardiorenal Med 2019 Apr 17;9(4):212-221. Epub 2019 Apr 17.

Kidney Disease Branch, NIDDK, Bethesda, Maryland, USA,

Background: Observational studies show that African American (AA) dialysis patients have longer survival than European Americans. We hypothesized that apolipoprotein L1 (APOL1) genetic variation, associated with nephropathy in AAs, contributes to the survival advantage in AA dialysis patients.

Methods: We examined the association between race and mortality among 37,097 adult dialysis patients, including 54% AAs and 46% European Americans from a large dialysis organization (entry period from July 2001 to June 2006, follow-up through June 2007), within each cause of end-stage renal disease (ESRD) category associated with APOL1 renal risk variants using Cox proportional hazard models. Read More

View Article

Download full-text PDF

Source
https://www.karger.com/Article/FullText/496472
Publisher Site
http://dx.doi.org/10.1159/000496472DOI Listing
April 2019
7 Reads

Key Updates in Cardio-Nephrology from 2018: Springboard to a Bright Future.

Cardiorenal Med 2019 Apr 17;9(4):222-228. Epub 2019 Apr 17.

Baylor University Medical Center, Dallas, Texas, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000498916DOI Listing
April 2019
1 Read

Multi-Omics Approach: New Potential Key Mechanisms Implicated in Cardiorenal Syndromes.

Cardiorenal Med 2019 Apr 2;9(4):201-211. Epub 2019 Apr 2.

Department of Nephrology, Dialysis and Transplant, San Bortolo Hospital, Vicenza, Italy.

Cardiorenal syndromes (CRS) include a scenario of clinical interactions characterized by the heart and kidney dysfunction. The crosstalk between cardiac and renal systems is clearly evidenced but not completely understood. Multi-factorial mechanisms leading to CRS do not involve only hemodynamic parameters. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000497748DOI Listing

A Novel Fluorescent Clinical Method to Rapidly Quantify Plasma Volume.

Cardiorenal Med 2019 7;9(3):168-179. Epub 2019 Mar 7.

Baylor College of Medicine, Houston, Texas, USA.

Objectives: To determine the performance of a rapid fluorescent indicator technique for measuring plasma volume (PV).

Methods: This was an open-label, observational evaluation of a two-component intravenous visible fluorescent dye technique to rapidly measure PV in 16 healthy subjects and 16 subjects with chronic kidney disease (8 stage 3 and 8 stage 4 CKD), at 2 clinical research sites. The method consisted of a single intravenous injection of 12 mg of a large 150-kDa carboxy-methyl dextran conjugated to a fluorescent rhodamine-derived dye as the PV marker (PVM), and 35 mg of a small 5-kDa carboxy-methyl dextran conjugated to fluorescein, the renal clearance marker. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000496480DOI Listing
March 2019
1 Read

Calculated Serum Osmolality, Acute Kidney Injury, and Relationship to Mortality after Percutaneous Coronary Intervention.

Cardiorenal Med 2019 7;9(3):160-167. Epub 2019 Mar 7.

The Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA,

Background: Data on the associations between serum osmolality (sOsmo) and acute kidney injury (AKI) as well as short- and long-term mortality in patients with coronary artery disease (CAD) undergoing percutaneous coronary intervention (PCI) are limited.

Objectives: To investigate the association between sOsmo and development of AKI and clinical outcomes in patients undergoing PCI.

Methods: We investigated 1,927 consecutive patients undergoing PCI from the registry of a single center. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000494807DOI Listing
March 2019
3 Reads

Cardiac Abnormalities in Children with Autosomal Recessive Polycystic Kidney Disease.

Cardiorenal Med 2019 7;9(3):180-189. Epub 2019 Mar 7.

Nephrology and Dialysis Unit, Department of Pediatric Subspecialties, Bambino Gesù Children's Hospital - IRCSS, Rome, Italy.

Background: No previous study has defined the prevalence of cardiac geometric and mechanical function abnormalities through the analysis of advanced echocardiographic parameters in children with autosomal recessive polycystic kidney disease (ARPKD).

Aim: The purpose of this study was to evaluate cardiac geometry and function through advanced echocardiography in a well-characterized sample of pediatric patients with ARPKD.

Methods: Standard echocardiograms were obtained in 27 children with ARPKD (0-18 years) and in 88 healthy children of similar age, gender distribution, and body build. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000496473DOI Listing
March 2019
1 Read

Grading of Left Ventricular Diastolic Dysfunction with Preserved Systolic Function by the 2016 American Society of Echocardiography/European Association of Cardiovascular Imaging Recommendations Contributes to Predicting Cardiovascular Events in Hemodialysis Patients.

Cardiorenal Med 2019 7;9(3):190-200. Epub 2019 Mar 7.

Department of Hemovascular Medicine and Artificial Organs, Faculty of Medicine, University of Miyazaki, Miyazaki City, Japan.

Background: Left ventricular diastolic dysfunction (LVDD) causes heart failure with a preserved left ventricular ejection fraction (LVEF) in the general population.

Objective: To examine the relationships between the LVDD grades of the 2016 American Society of Echocardiography/European Association of Cardiovascular Imaging (ASE/EACVI) recommendations and several arteriosclerotic parameters and major cardiovascular events (MACE) in hemodialysis patients with preserved LVEF.

Method: Sixty-three prevalent hemodialysis patients (median age [interquartile range], 69 [64-75] years, 31. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000496064DOI Listing

Multivessel Coronary Revascularization Strategies in Patients with Chronic Kidney Disease: A Meta-Analysis.

Cardiorenal Med 2019 7;9(3):145-159. Epub 2019 Mar 7.

Department of Cardiovascular Medicine, The Second Xiangya Hospital, Central South University, Changsha, China,

Background: Early revascularization can lead to better prognosis in multivessel coronary artery disease (CAD) patients with chronic kidney disease (CKD). However, whether coronary artery bypass grafting (CABG) or percutaneous coronary intervention (PCI) is better remains unknown.

Methods: We searched PubMed and the Cochrane Library database from inception until December 9, 2017, for articles that compare outcomes of CABG and PCI in multivessel CAD patients with CKD. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000494116DOI Listing
March 2019
3 Reads

Central Venous Stenosis after Hemodialysis: Case Reports and Relationships to Catheters and Cardiac Implantable Devices.

Cardiorenal Med 2019 27;9(3):135-144. Epub 2019 Feb 27.

Nephrology Division, University of Naples - "Luigi Vanvitelli" - Medical School, Naples, Italy,

The appropriate vascular access for hemodialysis in patients with cardiac implantable electronic devices (CIED) is undefined. We describe two cases of end-stage renal disease patients with CIED and tunneled central venous catheter (CVC) who developed venous cava stenosis: (1) a 70-year-old man with sinus node disease and pacemaker in 2013, CVC, and a Brescia-Cimino forearm fistula in 2015; (2) a 75-year-old woman with previous ventricular arrhythmia with implanted defibrillator in 2014 and CVC in 2016. In either case, after about 1 year from CVC insertion, patients developed superior vena cava (SVC) syndrome due to stenosis diagnosed by axial computerized tomography. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000496065DOI Listing
February 2019
2 Reads

Customization of Peritoneal Dialysis in Cardiorenal Syndrome by Optimization of Sodium Extraction.

Cardiorenal Med 2019 6;9(2):117-124. Epub 2019 Feb 6.

Department of Nephrology, San Bortolo Hospital, Vicenza, Italy.

Background: Peritoneal dialysis (PD) has emerged as a mechanistically relevant therapeutic option for patients with heart failure (HF), volume overload, and varying degrees of renal dysfunction (i.e., chronic cardiorenal syndrome). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000495703DOI Listing
February 2019
1 Read

NT-proBNP in the Prognosis of Death or Need for Renal Replacement Therapy in Patients with Stage 3-5 Chronic Kidney Disease.

Cardiorenal Med 2019 6;9(2):125-134. Epub 2019 Feb 6.

Department of Internal Medicine and Cardiology, Medical University of Warsaw, Warsaw, Poland.

Background: The risk of cardiovascular (CV) complications is much greater in patients with chronic kidney disease (CKD). The aim of this study was to assess predictors of mortality, renal failure progression, and the need for dialysis in patients with CKD.

Methods: The study group consisted of 70 patients with stage 3-5 CKD, followed up on average for 33. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000496238DOI Listing
February 2019
3 Reads

Biomarkers of Inflammation, Fibrosis, and Acute Kidney Injury in Patients with Heart Failure with and without Left Ventricular Assist Device Implantation.

Cardiorenal Med 2019 30;9(2):108-116. Epub 2019 Jan 30.

Division of Cardiovascular Surgery, Peter Munk Cardiac Centre, University Health Network, University of Toronto, Toronto, Ontario, Canada,

Background/aims: Renal dysfunction or renal failure is a common complication in left ventricular assist device (LVAD) recipients and is associated with reduced survival. To date, serum creatinine and glomerular filtration rate (GFR) are used for the evaluation of kidney function. However, serum creatinine and GFR have limitations. Read More

View Article

Download full-text PDF

Source
https://www.karger.com/Article/FullText/494090
Publisher Site
http://dx.doi.org/10.1159/000494090DOI Listing
January 2019
3 Reads

Outcomes of Moderate-to-Severe Acute Kidney Injury following Left Ventricular Assist Device Implantation.

Cardiorenal Med 2019 23;9(2):100-107. Epub 2019 Jan 23.

Center for Advanced Heart and Lung Disease, Baylor University Medical Center, Dallas, Texas, USA,

Background: Although acute kidney injury (AKI) is a common complication following cardiac surgery, less is known about the occurrence and consequences of moderate/severe AKI following left ventricular assist device (LVAD) implantation.

Methods: All patients who had an LVAD implanted at our center from 2008 to 2016 were reviewed to determine the incidence of, and risk factors for, moderate/severe (stage 2/3) AKI and to compare postoperative complications and mortality rates between those with and those without moderate/severe AKI.

Results: Of 246 patients, 68 (28%) developed moderate/severe AKI. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000492476DOI Listing
January 2019
2 Reads

Prolonged Hyperglycemia and Renal Failure after Primary Percutaneous Coronary Intervention.

Cardiorenal Med 2019 11;9(2):92-99. Epub 2019 Jan 11.

Department of Cardiology, Tel Aviv Sourasky Medical Center affiliated to the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel,

Background: There are limited data regarding the effect of long-standing hyperglycemia on the occurrence of acute kidney injury (AKI) in ST segment elevation myocardial infarction (STEMI) patients undergoing primary percutaneous coronary intervention (PCI).

Methods: We retrospectively studied 723 STEMI patients undergoing primary PCI. Patients were stratified into two groups according to glycated hemoglobin (HbA1c) levels as a marker of prolonged hyperglycemia: those with HbA1c < 7% and those with HbA1c ≥7%. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000495704DOI Listing
January 2019
2 Reads

Echocardiographic and Hemodynamic Parameters Associated with Diminishing Renal Filtration among Patients with Heart Failure with Preserved Ejection Fraction.

Cardiorenal Med 2019 13;9(2):83-91. Epub 2018 Dec 13.

Department of Medicine, Einstein Medical Center, Philadelphia, Pennsylvania, USA.

Background: Renal dysfunction is an important predictor of poor outcomes in patients with heart failure with preserved ejection fraction (HFpEF). Right ventricular (RV) dysfunction is implicated as one of the explanations for worsening renal function in cardiorenal syndrome. Novel right heart catheterization (RHC) parameters such as pulmonary artery pulsatility index (PAPi) and right atrial to pulmonary capillary wedge pressure ratio (RA:PCWP) have been found as predictors of RV dysfunction. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000494089DOI Listing
December 2018
10 Reads

Individualized Hemodialysis Treatment: A Perspective on Residual Kidney Function and Precision Medicine in Nephrology.

Cardiorenal Med 2019 11;9(2):69-82. Epub 2018 Dec 11.

Harold Simmons Center of Kidney Disease Research and Epidemiology, Division of Nephrology and Hypertension, University of California Irvine School of Medicine, Orange, California, USA,

Background: Residual kidney function (RKF) is often expected to inevitably and rapidly decline among hemodialysis patients and, hence, has been inadvertently ignored in clinical practice. The importance of RKF has been revisited in some recent studies. Given that patients with end-stage renal disease now tend to initiate maintenance hemodialysis therapy with higher RKF levels, there seem to be important opportunities for incremental hemo-dialysis by individualizing the dose and frequency according to their RKF levels. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000494808DOI Listing
December 2018
3 Reads

Impaired Left Ventricular Global Longitudinal Strain among Patients with Chronic Kidney Disease and End-Stage Renal Disease and Renal Transplant Recipients.

Cardiorenal Med 2019 28;9(1):61-68. Epub 2018 Nov 28.

Nephrology, Dialysis, and Transplantation, University of Genoa, Policlinico San Martino, Genoa, Italy,

Background: Although heart failure is the most prevalent cardiovascular disease associated with adverse outcome in chronic kidney disease (CKD) and after kidney transplantation, left ventricular (LV) systolic function is often preserved in renal patients. The aim of this study was to evaluate global longitudinal strain (GLS), which is reportedly a more accurate tool for detecting subclinical LV systolic dysfunction, in patients with various degrees of renal function impairment, including kidney transplant recipients (KTRs).

Methods: This prospective study evaluated demographic, clinical, and ultrasound data, including the assessment of LV GLS and mitral E peak velocity and averaged ratio of mitral to myocardial early velocities (E/e'), of 70 consecutive renal patients (20 with stage 2-4 CKD, 25 with end-stage renal disease on hemodialysis [HD], and 25 KTRs). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000494065DOI Listing
November 2018
1 Read

In-Hospital Mortality and Major Adverse Cardiovascular Events after Kidney Transplantation in the United States.

Cardiorenal Med 2019 14;9(1):51-60. Epub 2018 Nov 14.

Division of Nephrology, Department of Medicine, Einstein Medical Center, Philadelphia, Pennsylvania, USA.

Background: Kidney transplantation (KT) is the treatment of choice for end-stage kidney disease. Cardiovascular disease is a major determinant of morbidity and mortality in patients with KT. Temporal trends in perioperative cardiovascular outcomes after KT are understudied, especially in light of an aging KT waitlist population. Read More

View Article

Download full-text PDF

Source
https://www.karger.com/Article/FullText/492731
Publisher Site
http://dx.doi.org/10.1159/000492731DOI Listing
November 2018
19 Reads

Derived Subendocardial Viability Ratio and Cardiovascular Events in Patients with Chronic Kidney Disease.

Cardiorenal Med 2019 8;9(1):41-50. Epub 2018 Nov 8.

Medical Faculty, University of Maribor, Maribor, Slovenia.

Background: Chronic kidney disease (CKD) is a well-known mortality risk factor. The subendocardial viability ratio (SEVR) is one of the pulse wave analysis parameters that constitutes a non-invasive measure of coronary perfusion. We aimed to assess the prognostic value of the SEVR for cardiovascular outcome in non-dialysis CKD patients. Read More

View Article

Download full-text PDF

Source
https://www.karger.com/Article/FullText/493512
Publisher Site
http://dx.doi.org/10.1159/000493512DOI Listing
November 2018
13 Reads

Enteral Baicalin, a Flavone Glycoside, Reduces Indicators of Cardiac Surgery-Associated Acute Kidney Injury in Rats.

Cardiorenal Med 2019 7;9(1):31-40. Epub 2018 Nov 7.

The Affiliated Hospital of Guizhou Medical University, Guiyang City, China.

Background/aims: Cardiac surgery-associated acute kidney injury (CSA-AKI) is one of the most common postoperative complications in intensive care medicine. Baicalin has been shown to have anti-inflammatory and antioxidant roles in various disorders. We aimed to test the protective effects of baicalin on CSA-AKI using a rat model. Read More

View Article

Download full-text PDF

Source
https://www.karger.com/Article/FullText/492159
Publisher Site
http://dx.doi.org/10.1159/000492159DOI Listing
November 2018
9 Reads

Early Left Ventricular Dysfunction Detected by Speckle Tracking in Long-Term Hemodialysis Patients with Valvular Calcification.

Cardiorenal Med 2019 31;9(1):22-30. Epub 2018 Oct 31.

Purpose: Cardiac valve calcification (VC) is very common in patients on hemodialysis. However, the definite effect of VC on left ventricular (LV) geometry and function in this population is unknown, especially when LV ejection fraction (LVEF) is normal. The aim of this study was to determine the effect of VC on LV geometry and function in long-term hemodialysis patients by conventional echocardiography and two-dimensional speckle tracking echocardiography (2D-STE). Read More

View Article

Download full-text PDF

Source
https://www.karger.com/Article/FullText/491679
Publisher Site
http://dx.doi.org/10.1159/000491679DOI Listing
October 2018
19 Reads

Chronic Hyperkalemia in Cardiorenal Patients: Risk Factors, Diagnosis, and New Treatment Options.

Cardiorenal Med 2019 25;9(1):8-21. Epub 2018 Oct 25.

Department of Nephrology and Dialysis, ASTT Lariana, S. Anna Hospital, Como, Italy.

Chronic hyperkalemia (HK) is a serious medical condition that often manifests in patients with chronic kidney disease (CKD) and heart failure (HF) leading to poor outcomes and necessitating careful management by cardionephrologists. CKD, HF, diabetes, and renin-angiotensin-aldosterone system inhibitors use is known to induce HK. Current therapeutic options are not optimal, as pointed out by a large number of CKD and HF patients with HK. Read More

View Article

Download full-text PDF

Source
https://www.karger.com/Article/FullText/493395
Publisher Site
http://dx.doi.org/10.1159/000493395DOI Listing
October 2018
17 Reads

Hepatorenal Syndrome or Hepatocardiorenal Syndrome: Revisiting Basic Concepts in View of Emerging Data.

Cardiorenal Med 2019 17;9(1):1-7. Epub 2018 Sep 17.

Department of Nephrology, San Bortolo Hospital, Vicenza, Italy.

Background: Accumulating evidence on the pathophysiology of hepatorenal syndrome has challenged the conventional model of liver-kidney connection. While liver cirrhosis is traditionally considered the origin of a cascade of pathophysiologic mechanisms directly affecting other organs such as the kidney, emerging data point to the heart as the potential mediator of the untoward renal effects.

Summary: Herein, we briefly review the often-overlooked contribution of the heart to circulatory dysfunction in hepatorenal syndrome and put forward evidence arguing for the involvement of systemic inflammation and endothelial dysfunction in this setting. Read More

View Article

Download full-text PDF

Source
https://www.karger.com/Article/FullText/492791
Publisher Site
http://dx.doi.org/10.1159/000492791DOI Listing
September 2018
17 Reads

Impact of KDIGO-Defined Acute Kidney Injury on Mortality after Percutaneous Coronary Intervention for Acute Myocardial Infarction.

Cardiorenal Med 2018 17;8(4):332-339. Epub 2018 Sep 17.

Department of Nephrology, University Medical Center Maribor, Maribor, Slovenia.

Background: There are limited data regarding the incidence and long-term impact of acute kidney injury (AKI) according to the KDIGO guidelines on the outcome in patients with myocardial infarction (MI) treated with percutaneous coronary intervention (PCI). The aim of the study was to evaluate the prevalence of AKI, as classified by the KDIGO criteria, and its association with long-term mortality.

Methods: Data from 5,859 MI patients undergoing PCI at our institution were analyzed. Read More

View Article

Download full-text PDF

Source
https://www.karger.com/Article/FullText/492287
Publisher Site
http://dx.doi.org/10.1159/000492287DOI Listing
March 2019
4 Reads

Levels of Proinflammatory Cytokines, Oxidative Stress, and Tissue Damage Markers in Patients with Acute Heart Failure with and without Cardiorenal Syndrome Type 1.

Cardiorenal Med 2018 11;8(4):321-331. Epub 2018 Sep 11.

Department of Nephrology, Dialysis and Transplantation, San Bortolo Hospital, Vicenza, Italy.

Background: Cardiorenal syndrome type 1 (CRS type 1) is characterized by a rapid worsening of cardiac function leading to acute kidney injury (AKI). Inflammation and oxidative stress seem to play a pivotal role in its pathophysiology. In this in vivo study, we examined the putative role of inflammation and humoral markers in the pathogenesis of the CRS type 1. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000492602DOI Listing
March 2019
3 Reads

Urine Cofilin-1 Detection for Predicting Type 1 Cardiorenal Syndrome in the Coronary Care Unit: A Gold Nanoparticle- and Laser-Based Approach.

Cardiorenal Med 2018 17;8(4):302-310. Epub 2018 Aug 17.

College of Medicine, Chang Gung University, Taoyuan, Taiwan.

Background: Type 1 cardiorenal syndrome (CRS) is a severe complication for acute decompensated heart failure patients. This study aimed at evaluating the feasibility of using the gold nanoparticle-based localized surface plasmon-coupled fluorescence biosensor (LSPCFB) to detect urine cofilin-1 as a biomarker for predicting CRS among patients in the coronary care unit (CCU).

Methods: A total of 44 patients were included with prospectively collected urine and blood samples. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000490927DOI Listing
March 2019
6 Reads

Relationship between Plasma Proprotein Convertase Subtilisin/Kexin Type 9 and Estimated Glomerular Filtration Rate in the General Chinese Population.

Cardiorenal Med 2018 17;8(4):311-320. Epub 2018 Aug 17.

Background: Elevated levels of proprotein convertase subtilisin/kexin type 9 (PCSK9) have been reported to be related to dyslipidemia, including patients with kidney dysfunction. However, its association with estimated glomerular filtration rate (eGFR) in individuals with normal serum creatinine (SCr) has not been determined.

Methods: A total of 2,089 subjects with normal SCr and without lipid-lowering treatment were consecutively enrolled in this study. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000490766DOI Listing
March 2019
3 Reads

Cardionephrology: Proposal for a Futuristic Educational Approach to a Contemporary Need.

Cardiorenal Med 2018 8;8(4):296-301. Epub 2018 Aug 8.

Department of Nephrology, San Bortolo Hospital, Vicenza, Italy.

The field of cardiorenal medicine is vast, rapidly expanding, and complex. Conventional nephrology training programs provide the fellows with the necessary core knowledge to provide general care for patients with renal and cardiovascular diseases. However, there is a need for focused training of interested physicians to master the specialized aspects of these exceedingly common clinical scenarios and optimize the care of such patients. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000490744DOI Listing
March 2019
4 Reads

Detection of Atherosclerotic Cardiovascular Disease in Patients with Advanced Chronic Kidney Disease in the Cardiology and Nephrology Communities.

Cardiorenal Med 2018 3;8(4):285-295. Epub 2018 Aug 3.

New York University School of Medicine, New York, New York, USA.

Background: Atherosclerotic cardiovascular disease (ASCVD) is a leading cause of morbidity and mortality among patients with chronic kidney disease (CKD) with a glomerular filtration rate of < 60 mL/min/1.73 m2 body surface area. The availability of high-quality randomized controlled trial data to guide management for the population with CKD and ASCVD is limited. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000490768DOI Listing
March 2019
4 Reads

Hyponatremia in Acute Heart Failure in Relation to Hematocrit Levels: Clinical Relevance and Prognostic Implication.

Cardiorenal Med 2018 25;8(4):259-270. Epub 2018 Jul 25.

Cardiovascular Diseases Unit, Department of Internal Medicine, University of Siena, Siena, Italy.

Background: Hyponatremia is the most common electrolyte abnormality found in hospitalized patients with acute heart failure (AHF) and is related to poor prognosis. This study sought to evaluate: (1) the different prognostic impact of dilutional versus depletional hyponatremia, evaluating short- and long-term outcome; (2) the relationship between both types of hyponatremia and intravenous furosemide dose, renal function changes, and persistent congestion at discharge.

Methods: This retrospective single-center study included 233 consecutive patients with a primary diagnosis of AHF. Read More

View Article

Download full-text PDF

Source
https://www.karger.com/Article/FullText/490767
Publisher Site
http://dx.doi.org/10.1159/000490767DOI Listing
March 2019
4 Reads

Left Ventricular Strain and Dyssynchrony in Young and Middle-Aged Peritoneal Dialysis Patients and Healthy Controls: A Case-Matched Study.

Cardiorenal Med 2018 25;8(4):271-284. Epub 2018 Jul 25.

Department of Cardiology, The Second Affiliated Hospital of Soochow University, Suzhou, China.

Background: This study aimed to evaluate the role of two-dimensional speckle-tracking imaging (2D-STI) and myocardial layer-specific analysis in evaluating early left ventricular (LV) myocardial function and systolic dyssynchrony in young and middle-aged uremic patients undergoing peritoneal dialysis (PD).

Methods: We enrolled 31 PD patients aged ≤65 years with preserved LV ejection fraction (LVEF, ≥54%) as the PD group and 49 age-matched healthy people as the control group. Echocardiography was used to assess the left atrial diameter index (LADI, LAD/BSA), LV mass index (LVMI), LVEF, peak early diastolic velocity/late diastolic velocity (E/A) (measured by pulsed Doppler), and peak early diastolic velocity (by pulsed Doppler)/peak velocity of the early diastolic wave (by pulsed-wave tissue Doppler) (E/e'). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000490395DOI Listing
March 2019
25 Reads

CXCL12 in Patients with Chronic Kidney Disease and Healthy Controls: Relationships to Ambulatory 24-Hour Blood Pressure and Echocardiographic Measures.

Cardiorenal Med 2018 18;8(3):249-258. Epub 2018 Jul 18.

Chair and Department of Cardiology, Hypertension and Internal Medicine, Medical University of Warsaw, Warsaw, Poland.

Background/aims: Chronic kidney disease is a pro-inflammatory condition where the interplay between different regulatory pathways and immune cells mediates an unfavorable remodeling of the vascular wall and myocardial hypertrophy. These mechanisms include the action of CXCL12. The aim of this study is to evaluate the association between serum CXCL12 with left ventricular hypertrophy (LVH) and blood pressure control in chronic kidney disease (CKD) patients. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000490396DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6170919PMC
March 2019
12 Reads

Plasma Level of Retinol-Binding Protein 4, N-Terminal proBNP and Renal Function in Older Patients Hospitalized for Heart Failure.

Cardiorenal Med 2018 4;8(3):237-248. Epub 2018 Jul 4.

Pathophysiology Unit, Department of Pathophysiology, School of Medicine in Katowice, Medical University of Silesia, Katowice, Poland.

Background/aim: Elevated plasma concentration of retinol-binding protein 4 (RBP4) has recently emerged as a potential new risk factor for cardiovascular diseases, including hypertension (HT) and coronary artery disease (CAD). Limited data suggest that RBP4 promotes inflammatory damage to cardiomyocytes and participates in the development of heart failure (HF). This study aimed to analyze the relationship between concentrations of plasma RBP4 and serum N-terminal proBNP (NT-proBNP), a powerful biomarker of left ventricle dysfunction, in the older Polish population. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000489403DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6170924PMC
March 2019
11 Reads

Differential Impact of Chronic Kidney Disease on Coronary Calcification and Atherosclerosis in Asymptomatic Individuals with or without Diabetes: Analysis from a Coronary Computed Tomographic Angiography Registry.

Cardiorenal Med 2018 29;8(3):228-236. Epub 2018 Jun 29.

Cardiovascular Center and Cardiology Division, Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul, Republic of Korea.

Aim: The aim of this study was to assess the combined effects of chronic kidney disease (CKD) and diabetes on the extent and developmental pattern of coronary artery disease (CAD).

Methods: A total of 3,017 self-referred asymptomatic individuals without known CAD who underwent 64-channel dual-source coronary computed tomography angiography between 2006 and 2010 were enrolled. The patients were divided into six groups based on their diabetes status (nondiabetic or diabetic) and estimated glomerular filtration rate (eGFR) (eGFR > 90 mL/min/1. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000489097DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6170925PMC
March 2019
11 Reads

Metabolic Syndrome and the Iodine-Dose/Creatinine Clearance Ratio as Determinants of Contrast-Induced Acute Kidney Injury.

Cardiorenal Med 2018 15;8(3):217-227. Epub 2018 Jun 15.

Department of Cardiovascular Medicine, Rasoul-e-Akram General Hospital, IUMS, Tehran, Iran.

Background: Finding patients at risk of developing contrast-induced acute kidney injury (CI-AKI) is important because of its associated complications. In the present study, the contribution of different variables, such as the presence of metabolic syndrome (MetS), the volume creatinine clearance (V/CrCl) ratio, the iodine-dose (I-dose)/CrCl ratio, or hypertension, to CI-AKI was evaluated.

Methods: A total of 255 patients undergoing elective coronary angiography with or without intervention were enrolled and divided into a MetS and a control group. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000488374DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6170904PMC
March 2019
24 Reads

Determinants of Monocyte Apoptosis in Cardiorenal Syndrome Type 1.

Cardiorenal Med 2018 30;8(3):208-216. Epub 2018 May 30.

Department of Nephrology, Dialysis and Transplant, San Bortolo Hospital, Vicenza, Italy.

Background: Cardiorenal syndrome type 1 (CRS type 1) is characterized by a rapid worsening of cardiac function leading to acute kidney injury (AKI). Its pathophysiology is complex and not completely understood. In this study, we examined the role of apoptosis and the caspase pathways involved. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000488949DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6170906PMC
March 2019
11 Reads

Epicardial Fat Thickness in Patients with Autosomal Dominant Polycystic Kidney Disease.

Cardiorenal Med 2018 3;8(3):199-207. Epub 2018 May 3.

Unit of Secondary Hypertension, Department of Internal Medicine and Medical Specialties, Sapienza University of Rome, Rome, Italy.

Introduction: Autosomal dominant polycystic kidney disease (ADPKD) is associated with early organ damage such as left ventricular hypertrophy and higher cardiovascular risk when compared to essential hypertension (EH). Epicardial adipose tissue (EAT) is a new cardiovascular risk factor, but its role and correlation with left ventricular mass (LVM) in ADPKD is unknown.

Aims: we sought to investigate whether EAT is higher and related to LVM indexed by body surface area (LVMi) in hypertensive patients with ADPKD compared to those with EH. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000488064DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6167706PMC
March 2019
7 Reads

ω-3 Polyunsaturated Fatty Acid Postconditioning Protects the Isolated Perfused Rat Heart from Ischemia-Reperfusion Injury.

Cardiorenal Med 2018 11;8(3):173-182. Epub 2018 Apr 11.

Department of Pathology, 421 Hospital of PLA, Guangzhou, China.

Aims: This study aimed to evaluate the cardioprotective effects of ω-3 polyunsaturated fatty acids (PUFAs) postconditioning against ischemia-reperfusion (I/R) injury.

Methods: Sixty Sprague-Dawley rats were randomly divided into 4 groups (n = 15 for each) and used to generate the Langendorff isolated perfused rat heart model. The sham group received a continuous perfusion of 150 min. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000487490DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6167714PMC
March 2019
5 Reads

Pulmonary Catherization Data Correlate Poorly with Renal Function in Heart Failure.

Cardiorenal Med 2018 10;8(3):183-191. Epub 2018 Apr 10.

School of Public Health, The University of Texas Health Science Center at Houston, Houston, Texas, USA.

Background: The mechanisms of renal dysfunction in heart failure are poorly understood. We chose to explore the relationship of cardiac filling pressures and cardiac index (CI) in relation to renal dysfunction in advanced heart failure.

Objectives: To determine the relationship between renal function and cardiac filling pressures using the United Network of Organ Sharing (UNOS) pulmonary artery catherization registry. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000487203DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6170923PMC
March 2019
5 Reads

Preeclampsia as a Form of Type 5 Cardiorenal Syndrome: An Underrecognized Entity in Women's Cardiovascular Health.

Cardiorenal Med 2018 4;8(2):160-172. Epub 2018 Apr 4.

Baylor University Medical Center, Baylor Heart and Vascular Institute, Dallas, Texas, USA.

Background: Preeclampsia is a multisystem vascular disorder of pregnancy that remains a leading cause of maternal and fetal morbidity and mortality. Preeclampsia remains an underrecognized risk factor for future cardiovascular and kidney disease in women and represents the confluence of preexisting vascular risk factors with superimposed endothelial injury from placental mediated anti-angiogenic factors.

Summary: This review highlights the close relationship between preeclampsia and future cardiovascular and kidney disease. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000487646DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5968275PMC
March 2019
7 Reads

Relevance of B-Lines on Lung Ultrasound in Volume Overload and Pulmonary Congestion: Clinical Correlations and Outcomes in Patients on Hemodialysis.

Cardiorenal Med 2018 29;8(2):83-91. Epub 2017 Nov 29.

Background: Volume overload in patients on hemodialysis (HD) is an independent risk factor for cardiovascular mortality. B-lines detected on lung ultrasound (BLUS) assess extravascular lung water. This raises interest in its utility for assessing volume status and cardiovascular outcomes. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000476000DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5968278PMC
March 2019
10 Reads

High Right Ventricular Stroke Work Index Is Associated with Worse Kidney Function in Patients with Heart Failure with Preserved Ejection Fraction.

Cardiorenal Med 2018 28;8(2):123-129. Epub 2018 Feb 28.

Cardiology Division, Department of Internal Medicine, Einstein Medical Center, Philadelphia, Pennsylvania, USA.

Background: In patients with heart failure with preserved ejection fraction (HFpEF), worse kidney function is associated with worse overall cardiac mechanics. Right ventricular stroke work index (RVSWI) is a parameter of right ventricular function. The aim of our study was to determine the relationship between RVSWI and glomerular filtration rate (GFR) in patients with HFpEF. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000486629DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5968285PMC
March 2019
10 Reads

Impact of Chronic Kidney Disease on Cardiovascular and Renal Events in Patients Undergoing Percutaneous Coronary Intervention with Everolimus-Eluting Stent: Risk Stratification with C-Reactive Protein.

Cardiorenal Med 2018 27;8(2):151-159. Epub 2018 Mar 27.

Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan.

Background: Chronic kidney disease (CKD) and inflammation play critical roles in atherosclerosis. There is limited evidence regarding the relationship between CKD and patients receiving second-generation drug-eluting stents for coronary artery disease.

Objective: This study aimed to investigate the effect of CKD on cardiovascular and renal events in patients undergoing percutaneous coronary intervention (PCI) with everolimus-eluting stents (EES). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000486971DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5968296PMC
March 2019
16 Reads

The Effect of Mitochondrial Complex I-Linked Respiration by Isoflurane Is Independent of Mitochondrial Nitric Oxide Production.

Cardiorenal Med 2018 1;8(2):113-122. Epub 2018 Feb 1.

Institute of Clinical Medicine Research, Suzhou Hospital (West District) Affiliated to Nanjing Medical University, Suzhou Science and Technology Town Hospital, Suzhou, China.

Background: Anesthetic preconditioning (APC) of the myocardium is mediated in part by reversible alteration of mitochondrial function. Nitric oxide (NO) inhibits mitochondrial respiration and may mediate APC-induced cardioprotection. In this study, the effects of isoflurane on different states of mitochondrial respiration during the oxidation of complex I-linked substrates and the role of NO were investigated. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000485936DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5968286PMC
March 2019
7 Reads

The Role of Dendritic and Endothelial Cells in Cardiorenal Syndrome.

Cardiorenal Med 2018 22;8(2):92-104. Epub 2018 Jan 22.

Baylor Heart and Vascular Institute, Dallas, Texas, USA.

Backgrounds: Dendritic cells (DCs) are antigen-presenting cells that play a central role in innate and adaptive immune responses; however, the cross talk between cardiac and renal DCs in cardiorenal syndrome (CRS) has not yet been fully elucidated. In this setting, endothelial cells (ECs) also contribute to immune responses.

Summary: DC and EC activation and dysfunction have a central role in the pathogenesis of CRS. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000485937DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5968234PMC
March 2019
5 Reads

Personalized Statin Therapy and Coronary Atherosclerotic Plaque Burden in Asymptomatic Low/Intermediate-Risk Individuals.

Cardiorenal Med 2018 26;8(2):140-150. Epub 2018 Mar 26.

Biomedical and Metabolic Imaging Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA.

Background: Current guidelines for the primary prevention of atherosclerotic cardiovascular disease are based on the estimation of a predicted 10-year cardiovascular disease risk and the average relative risk reduction estimates from statin trials. In the clinical setting, however, decision-making is better informed by the expected benefit for the individual patient, which is typically lacking. Consequently, a personalized statin benefit approach based on absolute risk reduction over 10 years (ARR10 benefit threshold ≥2. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000487205DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5968283PMC
March 2019
19 Reads

Statins and New-Onset Diabetes in Cardiovascular and Kidney Disease Cohorts: A Meta-Analysis.

Cardiorenal Med 2018 22;8(2):105-112. Epub 2018 Jan 22.

Department of Internal Medicine, State University of New York Downstate Medical Center, Brooklyn, New York, USA.

Background: Statins have long been prescribed for the primary and secondary prevention of cardiovascular disease (CVD) and kidney disease. Their benefits and efficacy are widely accepted in current clinical practice, but like any other therapeutic agents, they have adverse effects. One of the emerging concerns with statin therapy is the development of new-onset diabetes mellitus (NODM), a dreaded risk factor for CVD and kidney disease and widely viewed as CVD equivalent. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000485196DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5968284PMC
March 2019
10 Reads

lncRNA UCA1 Is a Novel Regulator in Cardiomyocyte Hypertrophy through Targeting the miR-184/HOXA9 Axis.

Cardiorenal Med 2018 20;8(2):130-139. Epub 2018 Mar 20.

Cardiac hypertrophy is closely associated with a series of cardiovascular diseases, including heart failure and sudden death in particular. An in-depth comprehension of the pathogenesis of cardiac hypertrophy will improve the diagnosis and therapy of cardiac hypertrophy. It has been acknowledged that long noncoding RNAs/microRNAs (lncRNAs/miRNAs) are crucial regulators in diverse biological processes, including various cardiovascular diseases, in multiple manners. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000487204DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5968298PMC
March 2019
11 Reads

Combination Therapy with Renin-Angiotensin System Blockers and Vitamin D Receptor Activators for Predialysis Patients Is Associated with the Incidence of Cardiovascular Events after Dialysis Initiation: A Multicenter Nonrandomized Prospective Cohort Study.

Cardiorenal Med 2017 Dec 3;8(1):71-81. Epub 2017 Nov 3.

Fujita Health University School of Medicine, Toyoake, Japan.

Background: Several human studies reported that the combined use of renin-angiotensin system blockers (RASBs) and vitamin D receptor activators (VDRAs) resulted in decreased urinary protein excretion. However, it is unknown whether this combination therapy influences the incidence of cardiovascular (CV) events in dialysis patients.

Methods: The study was a multicenter nonrandomized prospective cohort analysis including 1,518 patients. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000479894DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5757592PMC
December 2017
6 Reads