One-Year Conservative Care Using Sodium Bicarbonate Supplementation Is Associated with a Decrease in Electronegative LDL in Chronic Kidney Disease Patients: A Pilot Study.
- Felipe Rizzetto,
- Denise Mafra,
- Ana Beatriz Barra,
- Gisella Pires de Melo,
- Dulcinéia Saes Parra Abdalla,
- Maurilo Leite
Cardiorenal Med 2017 Oct 17;7(4):334-341. Epub 2017 Aug 17.
Division of Nephrology, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro, Brazil.
Background: Chronic kidney disease (CKD) patients develop metabolic acidosis when approaching stages 3 and 4, a period in which accelerated atherogenesis may ensue. Studies in vitro show that low pH may increase low-density lipoprotein (LDL) oxidation, suggesting a role for chronic metabolic acidosis in atherosclerosis. The present study attempted to evaluate the effects of conservative care using oral sodium bicarbonate (NaHCO3) supplementation on the electronegative LDL [LDL(-)], a minimally oxidized LDL, plasma levels in CKD patients. Read More