336 results match your criteria Cardiorenal medicine[Journal]


Association between Serum Dickkopf-1 (DKK-1) Glycoprotein and Calcific Deposits on Cardiac Valves and Carotid Intimal-Medial Thickness in Hemodialysis Patients.

Cardiorenal Med 2020 07 8:1-10. Epub 2020 Jul 8.

Department of Mansoura Nephrology and Dialysis Unit (MNDU), Mansoura University, Mansoura, Egypt.

Background: Cardiac valve calcification (CVC) is common in hemodialysis (HD) patients, and associated with cardiovascular and all-cause mortality. Once believed to be a passive process, it is now understood that the Wnt signaling pathway has a major role. The aim of the current study was to assess the relationship between circulating DKK-1, a negative regulator of the Wnt signaling pathway, and CVC, as well as carotid intimal-medial thickness (CIMT) in HD patients. Read More

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http://dx.doi.org/10.1159/000507183DOI Listing

Cardiorenal Syndrome in Renal Transplant Recipients: Prevalence, Clinical Presentation, Treatment, and Outcome.

Cardiorenal Med 2020 Jul 6:1-7. Epub 2020 Jul 6.

Department of Nephrology, Arterial Hypertension, Dialysis, and Transplantation, University Hospital Center Zagreb, Faculty of Medicine, University of Zagreb, Zagreb, Croatia.

Background: Data on the cardiorenal syndrome (CRS) in renal transplant recipients (RTR) are scarce. We investigated the prevalence, clinical presentation, treatment, and outcomes of patients with CRS in our renal transplant cohort.

Methods: Charts and medical records of adult RTR were investigated to identify patients with renal allograft dysfunction and heart failure (HF) with reduced (HFrEF) or preserved (HFpEF) ejection fraction. Read More

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http://dx.doi.org/10.1159/000507728DOI Listing

Weathering the Cytokine Storm in COVID-19: Therapeutic Implications.

Cardiorenal Med 2020 Jun 29:1-11. Epub 2020 Jun 29.

Department of Cardiovascular and Thoracic Sciences, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy,

Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) recently emerged in Wuhan, Hubei-China, as responsible for the coronavirus disease 2019 (COVID-19) and then spread rapidly worldwide. While most individuals remain asymptomatic or develop only mild symptoms, approximately 5% develop severe forms of COVID-19 characterized by acute respiratory distress syndrome (ARDS) and multiple-organ failure (MOF) that usually require intensive-care support and often yield a poor prognosis.

Summary: The pathophysiology of COVID-19 is far from being completely understood, and the lack of effective treatments leads to a sense of urgency to develop new therapeutic strategies based on pathophysiological assumptions. Read More

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http://dx.doi.org/10.1159/000509483DOI Listing

Clinical and Operative Determinants of Acute Kidney Injury after Cardiac Surgery.

Cardiorenal Med 2020 Jun 29:1-13. Epub 2020 Jun 29.

International Renal Research Institute of Vicenza, Department of Nephrology, Dialysis and Transplantation, San Bortolo Hospital, Vicenza, Italy.

Introduction: Cardiac surgery-associated acute kidney injury (CSA-AKI) is associated with increased morbidity and mortality.

Objectives: We aimed to identify potentially modifiable risk factors for CSA-AKI.

Methods: This was asingle-center retrospective cohort study of 495 adult patients undergoing cardiac surgery. Read More

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http://dx.doi.org/10.1159/000507777DOI Listing

Clinical Characteristics and Outcomes of Community- and Hospital-Acquired Acute Kidney Injury with COVID-19 in a US Inner City Hospital System.

Cardiorenal Med 2020 18;10(4):223-231. Epub 2020 Jun 18.

Department of Medicine, Einstein Medical Center Philadelphia, Philadelphia, Pennsylvania, USA.

Introduction: Emerging data have described poor clinical outcomes from infection with the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV 2) among African American patients and those from underserved socioeconomic groups. We sought to describe the clinical characteristics and outcomes of acute kidney injury (AKI) in this special population.

Methods: This is a retrospective study conducted in an underserved area with a predominance of African American patients with coronavirus disease 2019 (COVID-19). Read More

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http://dx.doi.org/10.1159/000509182DOI Listing

Need for Objective Assessment of Volume Status in Critically Ill Patients with COVID-19: The Tri-POCUS Approach.

Cardiorenal Med 2020 27;10(4):209-216. Epub 2020 May 27.

Division of Nephrology, Hypertension and Renal Transplantation, University of Florida, Gainesville, Florida, USA.

As the coronavirus disease 2019 (COVID-19) continues to spread across the globe, the knowledge of its epidemiology, clinical features, and management is rapidly evolving. Nevertheless, the data on optimal fluid management strategies for those who develop critical illness remain sparse. Adding to the challenge, the fluid volume status of these patients has been found to be dynamic. Read More

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http://dx.doi.org/10.1159/000508544DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7316643PMC

NT-proBNP Concentration and Early Cardiac Dysfunction in Patients Receiving Dialysis: A Prospective Cohort Study.

Cardiorenal Med 2020 May 27:1-10. Epub 2020 May 27.

Department of Nephrology, Princess Alexandra Hospital, Brisbane, Queensland, Australia.

Introduction: The significance of N-terminal pro-B type natriuretic peptide (NT-proBNP) to detect heart failure in patients with end-stage kidney diseases on dialysis is controversial.

Objective: To assess whether serial measurements of NT-proBNP can predict worsening cardiac function in dialysis patients.

Methods: In this prospective, longitudinal, observational cohort study, the relationship between changes in monthly plasma NT-proBNP concentrations and changes in echocardiographic indices (left ventricular global longitudinal strain [GLS] and ejection fraction [LVEF]) were analyzed in dialysis patients without symptoms of heart failure over 24 months using multilevel mixed effects models. Read More

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http://dx.doi.org/10.1159/000507388DOI Listing

A Prospective, Randomized, Open-Label Trial of Atorvastatin versus Rosuvastatin in the Prevention of Contrast-Induced Acute Kidney Injury, Worsened Renal Function at 30 Days, and Clinical Events After Acute Coronary Angiography: the PRATO-ACS-2 Study.

Cardiorenal Med 2020 May 20:1-14. Epub 2020 May 20.

Division of Cardiology, Santo Stefano Hospital, Prato, Italy.

Background/aims: Both high-dose atorvastatin and rosuvastatin have been shown to reduce contrast-induced acute kidney injury (AKI) occurrence and improve clinical outcomes in high-risk coronary patients undergoing angiographic procedures. However, there is a lack of head-to-head comparative studies on the effects of atorvastatin or rosuvastatin administered upon hospital admission in statin-naive patients with non-ST segment elevation acute coronary syndrome (NSTE-ACS).

Methods: In this open-label, noninferiority study, we compared changes in renal function in 709 NSTE-ACS patients randomized to atorvastatin (80 mg upon admission followed by 40 mg/day) or rosuvastatin (40 mg upon admission followed by 20 mg/day). Read More

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http://dx.doi.org/10.1159/000506857DOI Listing

Fulminant Acute Kidney Injury in a Young Patient with Novel Coronavirus 2019.

Cardiorenal Med 2020 6;10(4):217-222. Epub 2020 May 6.

Department of Medicine, Einstein Medical Center, Philadelphia, Pennsylvania, USA.

Coronavirus disease 2019 (COVID-19) is a global pandemic affecting more than 200 countries and 180,000 cases in the United States. While the outbreak began in China, the number of cases outside of China exceeded those in China on March 15, 2020 and are currently rising at an exponential rate. The number of fatalities in the United States are expected to exceed more than Italy and China. Read More

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http://dx.doi.org/10.1159/000508179DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7251584PMC

Adverse Drug Reactions during Real-Life Use of Direct Oral Anticoagulants in Italy: An Update Based on Data from the Italian National Pharmacovigilance Network.

Cardiorenal Med 2020 30;10(4):266-276. Epub 2020 Apr 30.

UOC Cardiologia 1, Azienda Ospedaliera San Camillo Forlanini, Rome, Italy.

Background: The availability of direct oral anticoagulants (DOAC) in clinical practice has transformed the health care provided to patients for the prevention and treatment of thromboembolism. Safety and efficacy data guide clinicians in the choice of the drug used. To date, no evidence is available from head-to-head trials comparing different DOAC with regard to safety and efficacy; information is mainly derived from several meta-analyses and real-life studies. Read More

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http://dx.doi.org/10.1159/000507046DOI Listing

Prognostic Value of Cystatin C-Derived Estimated Glomerular Filtration Rate in Patients with Acute Heart Failure.

Cardiorenal Med 2020 21;10(4):232-242. Epub 2020 Apr 21.

Department of Internal Medicine, School of medicine, Kyungpook National University, Daegu, Republic of Korea.

Background: Renal function is closely related to cardiac function and an important prognostic marker in heart failure.

Objective: We aimed to test the prognostic value of cystatin C (cysC)-derived estimated glomerular filtration rates (eGFR) in comparison with eGFRs from creatinine solely based equations in patients with acute heart failure (AHF).

Methods: This study included 262 patients (65. Read More

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http://dx.doi.org/10.1159/000504084DOI Listing

[Hospitalization and Critical Illness in Chronic Kidney Disease].

Cardiorenal Med 2020 Apr 21:1-11. Epub 2020 Apr 21.

Selzman Institute for Kidney Health, Section of Nephrology, Department of Medicine, Baylor College of Medicine, Houston, Texas, USA,

Background: Patients with chronic kidney disease (CKD) who are hospitalized with a critical illness are at increased risk for adverse outcomes. We studied the predictors of hospitalization with critical illness among patients with non-dialysis-dependent CKD stages 3 and 4 in a safety-net healthcare setting.

Methods: A retrospective cohort study was conducted among patients ≥18 years of age with CKD stages 3 and 4 using a CKD registry from a safety-net healthcare system. Read More

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http://dx.doi.org/10.1159/000507047DOI Listing

Preeclampsia and the Ten-Year Risk of Incident Chronic Kidney Disease.

Cardiorenal Med 2020 16;10(3):188-197. Epub 2020 Apr 16.

Reproductive Endocrinology Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran,

Background: Although preeclampsia (PE), as an endothelial disorder can lead to renal dysfunction during pregnancy, results of studies focusing on the potential long-term potential effects of PE on renal function are insufficient and those available are controversial. This study investigated the incidence rate and risk of chronic kidney disease (CKD) among women with prior history of PE compared with healthy controls in a long-term population-based study.

Methods: This was a prospective population-based cohort study. Read More

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http://dx.doi.org/10.1159/000506469DOI Listing

Serum Klotho, Cardiovascular Events, and Mortality in Nondiabetic Chronic Kidney Disease.

Cardiorenal Med 2020 15;10(3):175-187. Epub 2020 Apr 15.

Department of Nephrology, Key Laboratory for the Prevention and Treatment of Chronic Kidney Disease of Chongqing, Kidney Center of PLA, Xinqiao Hospital, Army Medical University (Third Military Medical University), Chongqing, China,

Background: Experimental studies indicate that Klotho deficiency is a pathogenic factor for CKD-related complications, including cardiovascular disease (CVD). However, the association between serum Klotho and clinical outcomes in nondiabetic CKD patients needs to be further clarified. We aimed to determine whether serum Klotho levels are associated with CVD events and mortality in predialysis CKD patients without diabetes. Read More

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http://dx.doi.org/10.1159/000506380DOI Listing

Application of 17 Contrast-Induced Acute Kidney Injury Risk Prediction Models.

Cardiorenal Med 2020 14;10(3):162-174. Epub 2020 Apr 14.

Department of Cardiology, Medical School, Democritus University of Thrace, Alexandroupolis, Greece,

Introduction: Contrast-induced acute kidney injury (CI-AKI) is a frequent complication of percutaneous coronary interventions (PCI). Various groups have developed and validated risk scores for CI-AKI. Although the majority of these risk scores achieve an adequate accuracy, their usability in clinical practice is limited and greatly debated. Read More

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http://dx.doi.org/10.1159/000506379DOI Listing

Automated Remote Monitoring for Peritoneal Dialysis and Its Impact on Blood Pressure.

Cardiorenal Med 2020 14;10(3):198-208. Epub 2020 Apr 14.

Department of Nephrology Dialysis and Transplantation, Gazi University Faculty of Medicine, Ankara, Turkey.

Introduction: Peritoneal dialysis (PD) provides a safe, home-based continuous renal replacement therapy for patients. The adherence of the patients to the prescribed dialysis fluids cannot always be monitored by physicians. Remote monitoring automated peritoneal dialysis (RM-APD) can affect patients' compliance with treatment and, thus, clinical outcomes. Read More

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http://dx.doi.org/10.1159/000506699DOI Listing

Noninvasive Hemodynamic Profiles during Hemodialysis in Patients with and without Heart Failure.

Cardiorenal Med 2020 8;10(4):243-256. Epub 2020 Apr 8.

Division of Cardiology, Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.

Background: Although the dynamics of blood pressure (BP) during dialysis provide information related to the control system, the prognosis and relationships between temporal changes in intradialytic hemodynamic regulation, BP, and decreased cardiac function remain largely unclear.

Methods: Hemodynamic parameters, including heart rate (HR), stroke volume (SV), cardiac index, and systemic vascular resistance index, were recorded using a noninvasive hemodynamic device on a beat-by-beat basis in 40 patients on dialysis who were divided into three groups, i.e. Read More

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http://dx.doi.org/10.1159/000506470DOI Listing

Relationship between Microfibrillar-Associated Protein 4 Levels and Subclinical Myocardial Damage in Chronic Kidney Disease.

Cardiorenal Med 2020 8;10(4):257-265. Epub 2020 Apr 8.

Department of Biochemistry, Tekirdağ Namık Kemal University School of Medicine, Tekirdağ, Turkey.

Introduction: Chronic kidney disease (CKD) is a widespread health problem, in which mortality is most frequently due to cardiovascular diseases. Microfibrillar-associated protein 4 (MFAP4) is an extracellular matrix protein. MFAP4 is involved in several biological processes, particularly the maintenance of vascular integrity and extracellular matrix remodeling. Read More

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http://dx.doi.org/10.1159/000506827DOI Listing

Neutrophil Gelatinase-Associated Lipocalin for the Early Prediction of Acute Kidney Injury in ST-Segment Elevation Myocardial Infarction Patients Treated with Primary Percutaneous Coronary Intervention.

Cardiorenal Med 2020 10;10(3):154-161. Epub 2020 Mar 10.

Department of Cardiology, Tel Aviv Medical Center, affiliated to the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel,

Introduction And Objective: Neutrophil gelatinase-associated lipocalin (NGAL), a glycoprotein released by renal tubular cells, can be used as a marker of early tubular damage. We evaluated plasma NGAL level utilization for the identification of acute kidney injury (AKI) among ST-elevation myocardial infarction (STEMI) patients undergoing primary coronary intervention (PCI).

Methods: 131 STEMI patients treated with PCI were prospectively included. Read More

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http://dx.doi.org/10.1159/000506378DOI Listing

Inverse Relationship between Plasma Tumor Necrosis Factor-Like Weak Inducer of Apoptosis and Carotid Intima-Media Thickness among Patients Undergoing Hemodialysis and Peritoneal Dialysis.

Cardiorenal Med 2020 3;10(3):137-144. Epub 2020 Mar 3.

The Second Affiliated Hospital of Soochow University, Suzhou, China,

Background/aims: This study aimed to investigate the level of soluble tumor necrosis factor-like weak inducer of apoptosis (sTWEAK) and its correlation with micro-inflammation and atherosclerosis in continuous ambulatory peritoneal dialysis (PD) patients.

Methods: This retrospective study involved 23 healthy subjects (control group), 23 hemodialysis (HD) patients (HD group) and 26 PD patients (PD group). Serum biochemical measurements and sTWEAK assessments were tested. Read More

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http://dx.doi.org/10.1159/000503811DOI Listing

Benefits and Risks of Continuing Angiotensin-Converting Enzyme Inhibitors, Angiotensin II Receptor Antagonists, and Mineralocorticoid Receptor Antagonists during Hospitalizations for Acute Heart Failure.

Cardiorenal Med 2020 14;10(2):69-84. Epub 2020 Feb 14.

Baylor Heart and Vascular Institute, Dallas, Texas, USA.

Background: The renin-angiotensin-aldosterone axis plays a pivotal role in the pathophysiology of acute and chronic heart failure (HF) and represents an important target for guideline-directed medical therapy.

Summary: The use of appropriate directed medical therapies for inhibition of the renin-angiotensin-aldosterone axis in chronic HF has been the subject of several landmark clinical trials, with high levels of adherence exhibited in the outpatient setting. However, less clarity exists with respect to the initiation, continuation, and cessation of renin-angiotensin-aldosterone system inhibitors (RAASi) in the setting of acute HF and exacerbation of HF necessitating hospitalization. Read More

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http://dx.doi.org/10.1159/000504167DOI Listing
February 2020

Subclinical Contrast-Induced Acute Kidney Injury in Patients Undergoing Cerebral Computed Tomography.

Cardiorenal Med 2020 7;10(2):125-136. Epub 2020 Feb 7.

IRRIV-International Renal Research Institute Vicenza, Vicenza, Italy.

Introduction: The nephrotoxicity of modern contrast media remains controversial. Novel biomarkers of kidney damage may help in identifying a subclinical structural renal injury not revealed by widely used markers of kidney function.

Objective: The aim of this study was to investigate clinical (contrast-induced acute kidney injury [CI-AKI]) and subclinical CI-AKI (SCI-AKI) after intra-arterial administration of Iodixanol and Iopamidol in patients with an estimated glomerular filtration rate (eGFR) ≥60 mL/min/1. Read More

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http://dx.doi.org/10.1159/000505422DOI Listing
February 2020

Mineralcorticoid Receptor Antagonist Withdrawal for Hyperkalemia and Mortality in Patients with Heart Failure.

Cardiorenal Med 2020 24;10(3):145-153. Epub 2020 Jan 24.

University Cardiology Unit, Cardiothoracic Department, Policlinic University Hospital, Bari, Italy,

Background: Hyperkalemia is one of the most frequent side effects related to renin-angiotensin-aldosterone system (RAAS) inhibition, and can influence optimization of heart failure (HF) therapy.

Aim: To evaluate the occurrence of hyperkalemia in a series of outpatients with chronic HF and its relationship with RAAS inhibitor therapy.

Method: We evaluated consecutive outpatients with HF and a reduced left ventricular ejection fraction. Read More

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http://dx.doi.org/10.1159/000505286DOI Listing
January 2020

Angiopoietin-Like Protein 7 and Short-Term Mortality in Acute Heart Failure.

Cardiorenal Med 2020 21;10(2):116-124. Epub 2020 Jan 21.

Department of Cardiology, First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China,

Introduction: Angiopoietin-like protein 7 (ANGPTL7) is involved in extracellular matrix expression and inflammatory responses. However, the prognostic utility of ANGPTL7 among patients with acute heart failure (AHF) remains unclear.

Objective: To evaluate the association between ANGPTL7 and short-term mortality due to AHF. Read More

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http://dx.doi.org/10.1159/000504879DOI Listing
January 2020

Activation of the Nitric Oxide Pathway and Acute Myocardial Infarction Complicated by Acute Kidney Injury.

Cardiorenal Med 2020 20;10(2):85-96. Epub 2020 Jan 20.

Université Paris Diderot, PRES Sorbonne Paris Cité, Paris, France.

Background/aims: The pathophysiology of acute kidney injury (AKI) in ST-elevation myocardial infarction (STEMI) patients remains poorly explored. The involvement of the nitric oxide (NO) pathway has been demonstrated in experimental ischemic AKI. The aim of this study was to assess the predictive value of circulating biomarkers of the NO pathway for AKI in STEMI patients. Read More

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http://dx.doi.org/10.1159/000503718DOI Listing
January 2020

Hemodynamic and Laboratory Changes during Incremental Transition from Twice to Thrice-Weekly Hemodialysis.

Cardiorenal Med 2020 14;10(2):97-107. Epub 2020 Jan 14.

Harold Simmons Center for Kidney Disease Research and Epidemiology, Division of Nephrology and Hypertension, University of California Irvine, School of Medicine, Orange, California, USA,

Objective: Incremental hemodialysis (HD) is a strategy utilized to gradually intensify dialysis among patients with incident end-stage renal disease. However, there are scarce data about which patients' clinic status changes by increasing treatment frequency.

Methods: We retrospectively examined statistically de-identified data from 569 patients who successfully transitioned from twice- to thrice-weekly HD (2007-2011) and compared the differences in monthly-averaged values of hemodynamic and laboratory indices during the 3 months before and after the transition with the values at 1 month prior to transition serving as the reference. Read More

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http://dx.doi.org/10.1159/000504383DOI Listing
January 2020

Contrast Volume to Glomerular Filtration Ratio and Acute Kidney Injury among ST-Segment Elevation Myocardial Infarction Patients Treated with Primary Percutaneous Coronary Intervention.

Cardiorenal Med 2020 4;10(2):108-115. Epub 2019 Dec 4.

Department of Cardiology, Tel-Aviv Sourasky Medical Center affiliated to the Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel,

Introduction: The ratio of contrast media volume to glomerular filtration rate (contrast/GFR) has been shown to correlate with the occurrence of contrast-induced acute kidney injury (CI-AKI) in unselected patient populations who underwent percutaneous coronary intervention (PCI).

Objective: We evaluated the possible utilization of this marker and optimal cutoff among ST-elevation myocardial infarction (STEMI) patients undergoing primary PCI.

Methods: We retrospectively included 419 patients with STEMI treated with primary PCI. Read More

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http://dx.doi.org/10.1159/000504534DOI Listing
December 2019

Association between Plasma Dehydroepiandrosterone Sulfate and Carotid Intima-Media Thickness among Male and Female Patients with End-Stage Renal Disease on Hemodialysis.

Cardiorenal Med 2020 26;10(1):61-68. Epub 2019 Nov 26.

Department of Nephrology and Dialysis, Mansoura University, Mansoura, Egypt.

Background And Aim: Serum dehydroepiandrosterone sulfate (DHEA-S) is known to be lower in chronic kidney disease (CKD) patients and in those with cardiac disease, and correlates with a poor cardiovascular outcome. This study aimed to assess the correlation between DHEA-S and carotid intima-media thickness (CIMT) as a predictor of cardiovascular disease in hemodialysis (HD) patients.

Methods: A total of 88 HD patients were included in this cross-sectional study. Read More

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http://dx.doi.org/10.1159/000504083DOI Listing
November 2019

The Effects of SGLT2 Inhibitors on Cardiovascular and Renal Outcomes in Diabetic Patients: A Systematic Review and Meta-Analysis.

Cardiorenal Med 2020 19;10(1):1-10. Epub 2019 Nov 19.

Department of Medicine, Einstein Medical Center, Philadelphia, Pennsylvania, USA.

Background: Previous meta-analyses demonstrated the benefits of sodium-glucose cotransporter 2 inhibitors (SGLT2i) primarily on patients with established atherosclerotic cardiovascular disease (ASCVD), but with questionable efficacy on patients at risk of ASCVD. Additionally, evidence of beneficial cardiorenal outcomes in patients with estimated glomerular filtration rate (eGFR) <60 mL/min/1.73 m2 with the CV outcomes trials remains unclear. Read More

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http://dx.doi.org/10.1159/000503919DOI Listing
November 2019

Serum Resistin, Adenylate Cyclase-Associated Protein 1 Gene Expression, and Carotid Intima-Media Thickness in Patients with End-Stage Renal Disease and Healthy Controls.

Cardiorenal Med 2020 13;10(1):51-60. Epub 2019 Nov 13.

Department of Medical Biochemistry, Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia.

Background: Human resistin is a proinflammatory cytokine with significant proatherogenic effects which acts through adenylyl cyclase-associated protein 1 (CAP1). Chronic kidney disease (CKD) and end-stage renal disease (ESRD) patients have increased cardiovascular risk and resistin levels. Previous studies indicated resistin significance as a predictor of mortality in CKD. Read More

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http://dx.doi.org/10.1159/000503416DOI Listing
November 2019

Mitochondrial-Derived Peptide MOTS-c Attenuates Vascular Calcification and Secondary Myocardial Remodeling via Adenosine Monophosphate-Activated Protein Kinase Signaling Pathway.

Cardiorenal Med 2020 6;10(1):42-50. Epub 2019 Nov 6.

Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

Introduction: Vascular calcification (VC) is a complex, regulated process involved in many disease entities. So far, there are no treatments to reverse it. Exploring novel strategies to prevent VC is important and necessary for VC-related disease intervention. Read More

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http://dx.doi.org/10.1159/000503224DOI Listing
November 2019

Mineralocorticoid Receptor Antagonists and Renal Outcomes in Heart Failure Patients with and without Chronic Kidney Disease.

Cardiorenal Med 2020 30;10(1):32-41. Epub 2019 Oct 30.

Divisions of Nephrology, Department of Medicine, McGill University Health Centre, Montreal, Québec, Canada.

Introduction: The effect of mineralocorticoid receptor antagonists (MRAs) on chronic kidney disease (CKD) progression in patients with heart failure (HF) and with or without preexisting CKD has not been adequately studied.

Methods: We conducted a retrospective cohort study including consecutive adult patients followed at the HF clinic of a tertiary care center who had already been on an angiotensin-converting enzyme inhibitor (ACEI) or an angiotensin receptor blocker (ARB). Exposure to MRAs was assessed at 6 months from registration. Read More

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http://dx.doi.org/10.1159/000503223DOI Listing
October 2019

Hyperuricemia in US Population with Heart Failure: Causal or Incidental Bystander?

Cardiorenal Med 2019 23;9(6):341-343. Epub 2019 Oct 23.

Cardiovascular Diseases Unit, Department of Internal Medicine, Santa Maria alle Scotte Hospital Siena, University of Siena, Siena, Italy,

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http://dx.doi.org/10.1159/000503058DOI Listing
February 2020

Serial Urinary Tissue Inhibitor of Metalloproteinase-2 and Insulin-Like Growth Factor-Binding Protein 7 and the Prognosis for Acute Kidney Injury over the Course of Critical Illness.

Cardiorenal Med 2019 16;9(6):358-369. Epub 2019 Oct 16.

Center for Critical Care Nephrology, Department of Critical Care Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.

Introduction: Over the course of critical illness, there is a risk of acute kidney injury (AKI), and when it occurs, it is associated with increased length of stay, morbidity, and mortality. The urinary cell-cycle arrest markers tissue inhibitor of metalloproteinase-2 (TIMP-2) and insulin-like growth factor binding protein 7 (IGFBP7) have been utilized to predict the risk of AKI over the next 12 h from the time of sampling. The aim of this analysis was to evaluate the utility of [TIMP-2] × [IGFBP7] measured serially to anticipate the occurrence of AKI over the first 7 days of critical illness. Read More

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http://dx.doi.org/10.1159/000502837DOI Listing
July 2020
2 Reads

Acute Kidney Injury Biomarkers: Are We Ready for the Biomarker Curve?

Authors:
Claudio Ronco

Cardiorenal Med 2019 16;9(6):354-357. Epub 2019 Oct 16.

Department of Medicine, University of Padua, San Bortolo Hospital, Vicenza, Italy,

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http://dx.doi.org/10.1159/000503443DOI Listing
February 2020
1 Read

Aerobic Exercise Training and Nontraditional Cardiovascular Risk Factors in Hemodialysis Patients: Results from a Prospective Randomized Trial.

Cardiorenal Med 2019 9;9(6):391-399. Epub 2019 Oct 9.

Division of Nephrology, Department of Internal Medicine, Botucatu Medical School, São Paulo State University (UNESP), Botucatu, Brazil.

Introduction: Chronic kidney disease (CKD) patients have a high incidence of cardiovascular diseases (CVD) which increases their morbidity and mortality. A sedentary lifestyle in CKD is directly linked to the onset of CVD. Physical activity can bring beneficial effects to CKD patients. Read More

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http://dx.doi.org/10.1159/000501589DOI Listing
July 2020
2 Reads

Rein cardiaque: Historical Notes on Cardiorenal Syndrome.

Cardiorenal Med 2019 9;9(6):337-340. Epub 2019 Oct 9.

Department of Nephrology, Dialysis and Transplantation, International Renal Research Institute, St. Bortolo Hospital, Vicenza, Italy.

Cardiorenal syndrome describes an active inter-relationship between heart and renal malfunction. The notion of passive renal congestion because of heart dysfunction and the informative term "rein cardiaque" by the French pathologist Frédéric Justin Collet (1870-1966) that reiterates revolutionized physiological thinking based on autopsy findings will be briefly discussed here. Read More

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http://dx.doi.org/10.1159/000503222DOI Listing
July 2020
1 Read

Elevated Serum Uric Acid and Self-Reported Heart Failure in US Adults: 2007-2016 National Health and Nutrition Examination Survey.

Cardiorenal Med 2019 25;9(6):344-353. Epub 2019 Sep 25.

Department of Clinical and Applied Movement Sciences, University of North Florida, Jacksonville, Florida, USA.

Introduction: There is limited evidence examining the relationship between elevated serum uric acid (sUA) concentration and heart failure (HF) in United States (US) adults. The aim of the present study was to examine the association(s) between elevated sUA and HF using a nationally representative sample of US adults.

Methods: The final sample with complete data for this analysis (n = 17,349) included men and women aged ≥40 years who participated in the 2007-2016 National Health and Nutrition Examination Survey. Read More

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http://dx.doi.org/10.1159/000502438DOI Listing
July 2020
3 Reads

Changes in Estimated Glomerular Filtration after Balloon Pulmonary Angioplasty for Chronic Thromboembolic Pulmonary Hypertension.

Cardiorenal Med 2020 17;10(1):22-31. Epub 2019 Sep 17.

Department of Pulmonary Circulation, Thromboembolic Diseases and Cardiology, Centre of Postgraduate Medical Education, European Health Center Otwock, Otwock, Poland.

Background: Balloon pulmonary angioplasty (BPA) is a novel treatment option for inoperable or persistent chronic thromboembolic pulmonary hypertension (CTEPH). Little is known about renal function in CTEPH patients undergoing BPA.

Objectives: The aim of this study was to assess the frequency of contrast-induced acute kidney injury (CI-AKI) in patients with CTEPH undergoing BPA and to evaluate the relationship between hemodynamic and renal function. Read More

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http://dx.doi.org/10.1159/000502254DOI Listing
September 2019
2 Reads

Prognostic Value of Cysteine-Rich Protein 61 Combined with N-Terminal Pro-B-Type Natriuretic Peptide for Mortality in Acute Heart Failure Patients with and without Chronic Kidney Disease.

Cardiorenal Med 2020 30;10(1):11-21. Epub 2019 Aug 30.

Department of Cardiology, the First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.

Background: The ability of most biomarkers, such as N-terminal pro-B-type natriuretic peptide (NT-proBNP), to predict prognosis in heart failure can be affected by the state of renal function; therefore, there is the need for a biomarker that can predict prognosis accurately without the influence of renal function. The prognostic value of cysteine-rich protein 61 (CYR61/CCN1) in acute heart failure (AHF) patients has been proven.

Methods: A total of 248 patients hospitalized with AHF were recruited in this study, and serum CCN1 levels, NT-proBNP levels, and other necessary data of patients were collected upon admission. Read More

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http://dx.doi.org/10.1159/000501929DOI Listing
August 2019
2 Reads

Elevated Triglycerides (≥150 mg/dL) and High Triglycerides (200-499 mg/dL) Are Significant Predictors of Hospitalization for New-Onset Kidney Disease: A Real-World Analysis of High-Risk Statin-Treated Patients.

Cardiorenal Med 2019 26;9(6):400-407. Epub 2019 Aug 26.

Amarin Pharma Inc, Bedminster, New Jersey, USA.

Background: Dyslipidemia in kidney disease (KD) involves increased levels of triglycerides (TG) and TG-rich lipoproteins, with only minor changes in low-density lipoprotein cholesterol. The increasing prevalence of diabetic KD and the shared atherogenic lipid profile between KD and diabetes underscore the importance of understanding dyslipidemia in these patients. Previous studies suggest an association between elevated TG and new-onset KD. Read More

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http://dx.doi.org/10.1159/000502511DOI Listing
July 2020
1 Read

Invasive Hemodynamic Predictors of Renal Outcomes after Percutaneous Coronary Interventions.

Cardiorenal Med 2019 8;9(6):382-390. Epub 2019 Aug 8.

Department of Medicine, Einstein Medical Center, Philadelphia, Pennsylvania, USA.

Objectives: To determine the association of right heart invasive hemodynamic parameters with post-percutaneous coronary intervention (PCI) acute kidney injury (AKI).

Background: AKI after PCI is associated with a high morbidity and mortality. Various mechanisms are implicated in AKI after PCI. Read More

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http://dx.doi.org/10.1159/000500949DOI Listing
July 2020
5 Reads

New Approach to Slowing the Progression of Chronic Kidney Disease.

Authors:
Richard Solomon

Cardiorenal Med 2019 29;9(5):334-336. Epub 2019 Jul 29.

Nephrology, The University of Vermont Medical Center, Burlington, Vermont, USA,

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http://dx.doi.org/10.1159/000502105DOI Listing
January 2020

Systemic Succinate, Hypoxia-Inducible Factor-1 Alpha, and IL-1β Gene Expression in Autosomal Dominant Polycystic Kidney Disease with and without Hypertension.

Cardiorenal Med 2019 18;9(6):370-381. Epub 2019 Jul 18.

Transplant Immunology Division, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden.

Background And Objectives: Cyst pressure induces renin-angiotensin-aldosterone system activation and kidney hypoxia in autosomal dominant polycystic kidney disease (ADPKD). Lipopolysaccharide-induced Toll-like receptor activation causes metabolic disturbances that are triggered by increased succinate levels and hypoxia inducible factors, which results in inflammation via IL-1β activation. Since we aimed to investigate the role of both inflammation and hypoxia in the clinical course of ADPKD, via succinate levels from sera samples, HIF-1α gene expression from whole blood and urine samples and IL-1βgene expression from whole blood were measured. Read More

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http://dx.doi.org/10.1159/000500478DOI Listing
July 2020
2 Reads

Neurohormonal, Endocrine, and Immune Dysregulation and Inflammation in Cardiorenal Syndrome.

Cardiorenal Med 2019 2;9(5):265-273. Epub 2019 Jul 2.

International Renal Research Institute Vicenza (IRRIV), Vicenza, Italy.

"Organ crosstalk" is the complex physiological communication between different body systems, and it is necessary for the optimal equilibrium and functioning of the organism. In particular, heart and kidney function is tightly connected, and interplay between these two organs occurs through a vast array of dynamic and bidirectional mechanisms. The term cardiorenal syndrome (CRS) indicates an interaction between the heart and kidneys in acute and chronic disease settings. Read More

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http://dx.doi.org/10.1159/000500715DOI Listing
May 2020
3 Reads

Loss of the Normal Gradient in Arterial Compliance and Outcomes of Chronic Kidney Disease Patients.

Cardiorenal Med 2019 25;9(5):297-307. Epub 2019 Jun 25.

Department of Nephrology, Peking University Third Hospital, Beijing, China,

Background: In dialysis patients, loss of the normal gradient in arterial compliance, assessed by the pulse wave velocity (PWV) ratio, predicts all-cause mortality better than does carotid-femoral PWV (CF-PWV) alone. However, the prognostic significance of the PWV ratio for outcome in chronic kidney disease (CKD) patients remains unclear.

Methods: In this longitudinal cohort study, CKD patients who visited our CKD management clinic between April 27, 2006, and March 27, 2008, were included and followed up. Read More

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http://dx.doi.org/10.1159/000500479DOI Listing
May 2020
3 Reads

Plasma Lipopolysaccharide Concentrations in Cardiorenal Syndrome Type 1.

Cardiorenal Med 2019 25;9(5):308-315. Epub 2019 Jun 25.

IRRIV-International Renal Research Institute Vicenza, Vicenza, Italy.

Background: Cardiorenal syndrome (CRS) type 1 is characterized by a rapid worsening of cardiac function that leads to acute kidney injury (AKI). This study evaluated the role of lipopolysaccharide (LPS) in the development of AKI in patients with acute heart failure (AHF) and its relationship with renal parameters, to enable a better comprehension of the pathophysiology of CRS type 1.

Methods: We enrolled 32 AHF patients, 15 of whom were classified as having CRS type 1. Read More

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http://dx.doi.org/10.1159/000500480DOI Listing
May 2020
2 Reads

Echocardiographic Findings in Patients with Mild to Moderate Chronic Kidney Disease without Symptomatic Heart Failure: A Population-Based Study.

Cardiorenal Med 2019 25;9(5):284-296. Epub 2019 Jun 25.

Department of Nephrology, Skåne University Hospital, Malmö, Sweden,

Background: Renal dysfunction is an established risk factor for cardiovascular disease, but early disease states in both organs are poorly studied.

Objective: This cross-sectional population-based study aims to investigate if there is an early association between kidney function and echocardiographic markers of cardiac structure and diastolic function.

Methods: The study population consisted of 1,504 individuals with no prior history of congestive heart failure or asymptomatic left ventricular ejection fraction ≤40% and an estimated glomerular filtration rate (eGFR) based on cystatin C >15 mL/min/1. Read More

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http://dx.doi.org/10.1159/000499835DOI Listing
May 2020
4 Reads

Initial Concentrations of miR-1 MicroRNA Precursor and High-Sensitivity Troponin in the Diagnosis of Non-ST Myocardial Infarction among Patients with and Those without Chronic Kidney Disease.

Cardiorenal Med 2019 24;9(5):274-283. Epub 2019 Jun 24.

Department of Cardiology, The Third Affiliated Hospital of Soochow University, Changzhou, China,

Background: The early diagnosis of non-ST-segment elevation myocardial infarction (NSTEMI) in patients with chronic kidney disease (CKD) remains a challenge.

Methods: The study consecutively enrolled patients who had suffered from chest pain within 3 h whose electrocardiogram had no elevation in the ST segment. CKD was defined as an estimated glomerular filtration rate (eGFR) <60 mL/min/1. Read More

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http://dx.doi.org/10.1159/000499834DOI Listing
May 2020
17 Reads

APOL1 and Mortality in Patients on Dialysis.

Cardiorenal Med 2019 11;9(4):261-264. Epub 2019 Jun 11.

Department of Internal Medicine, Section on Nephrology, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA,

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http://dx.doi.org/10.1159/000501303DOI Listing
October 2019
12 Reads