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    216 results match your criteria Cardiorenal medicine[Journal]

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    Urinary Osteopontin Predicts Incident Chronic Kidney Disease, while Plasma Osteopontin Predicts Cardiovascular Death in Elderly Men.
    Cardiorenal Med 2017 Jun 25;7(3):245-254. Epub 2017 May 25.
    School of Health and Social Studies, Dalarna University, Falun, Sweden.
    Background And Objectives: The matricellular protein osteopontin is involved in the pathogenesis of both kidney and cardiovascular disease. However, whether circulating and urinary osteopontin levels are associated with the risk of these diseases is less studied.

    Design Setting Participants And Measurements: A community-based cohort of elderly men (Uppsala Longitudinal Study of Adult Men [ULSAM]; n = 741; mean age: 77 years) was used to study the associations between plasma and urinary osteopontin, incident chronic kidney disease, and the risk of cardiovascular death during a median of 8 years of follow-up. Read More

    Characterization of an Animal Model to Study Risk Factors and New Therapies for the Cardiorenal Syndrome, a Major Health Issue in Our Aging Population.
    Cardiorenal Med 2017 Jun 24;7(3):234-244. Epub 2017 May 24.
    Laboratory of Pathophysiology, University of Antwerp, Antwerp, Belgium.
    Background: The cardiorenal syndrome (CRS) is a major health problem in our aging population. The term was introduced to cover disorders of the kidneys and heart, whereby dysfunction of one organ may induce dysfunction of the other. As the natural history of the CRS is mostly slow, hence difficult to explore in clinical trials, adequate animal models combining cardiovascular and renal disease are required. Read More

    Estimated Glomerular Filtration Rate and 6-Minute Walk Distance in African Americans with Mild to Moderate Heart Failure.
    Cardiorenal Med 2017 Jun 24;7(3):227-233. Epub 2017 May 24.
    Department of Biobehavioral Health Science, University of Illinois at Chicago College of Nursing, Chicago, IL, USA.
    Background/aims: The 6-minute walk test is a measure of functional capacity in patients with heart failure (HF) or chronic kidney disease (CKD). The association between estimated glomerular filtration rate (eGFR) and 6-minute walk distance (6MWD) has not been investigated in African-Americans (AA), despite them having a higher incidence of CKD and chronic HF. Thus, our aim was to determine if eGFR was an independent predictor of 6MWD in AA >50 years of age with HF. Read More

    Brain Natriuretic Peptide Is a Marker of Fluid Overload in Incident Hemodialysis Patients.
    Cardiorenal Med 2017 Jun 29;7(3):218-226. Epub 2017 Apr 29.
    NephroCare Tassin-Charcot, Sainte-Foy-lès-Lyon, Nancy, France.
    Background/aims: Brain natriuretic peptide (BNP) is secreted by cardiomyocytes under stretch condition. High blood levels are associated with decreased patient survival in heart failure patients and in hemodialysis (HD) patients. We report the monthly BNP change in the first months of HD therapy in incident patients and its relationship with fluid removal and cardiac history (CH). Read More

    Recent Advances in Stroke Prevention in Patients with Atrial Fibrillation and End-Stage Renal Disease.
    Cardiorenal Med 2017 Jun 27;7(3):207-217. Epub 2017 Apr 27.
    Department of Medicine and Surgery, University of Milan-Bicocca, Milan, Italy.
    Background: Chronic kidney disease (CKD) is associated with a high prevalence of atrial fibrillation (AF), but in this population the risk/benefit ratio of anticoagulant therapy with vitamin K antagonists (VKA) for thromboprophylaxis is uncertain.

    Summary: In end-stage renal disease (ESRD) patients undergoing hemodialysis, VKA seem less effective in stroke prevention than in the general population, with an increased risk of major bleeding. Recently, novel oral anticoagulant agents (NOACs) have proven to be effective for stroke prevention in AF and have demonstrated an improved safety profile compared to VKA. Read More

    Nonparallel Progression of Left Ventricular Structure and Function in Long-Term Peritoneal Dialysis Patients.
    Cardiorenal Med 2017 Jun 22;7(3):198-206. Epub 2017 Apr 22.
    Department of Nephrology, Second Affiliated Hospital of Soochow University, Suzhou, China.
    Background/aims: Left ventricular hypertrophy and dysfunction are key cardiovascular risk factors of patients on peritoneal dialysis (PD). The purpose of this study was to investigate the dynamic changes of left ventricular (LV) structure and function in patients on long-term PD.

    Methods: Patients who underwent PD catheter insertions from January 2010 to December 2012 in our PD center were enrolled into this study. Read More

    Levocarnitine Injections Decrease the Need for Erythropoiesis-Stimulating Agents in Hemodialysis Patients with Renal Anemia.
    Cardiorenal Med 2017 Jun 20;7(3):188-197. Epub 2017 Apr 20.
    Division of Nephrology, Hypertension and Endocrinology, Department of Internal Medicine, Nihon University School of Medicine, Tokyo, Japan.
    Aims: The aim of this study was to evaluate the efficacy of levocarnitine injection for renal anemia in hemodialysis patients.

    Methods: In this randomized controlled clinical trial, we randomly assigned patients on maintenance hemodialysis at our hospital to receive levocarnitine injections (n = 30) or no injection (n = 30) and monitored the patients during 12 months of treatment. In the treatment group, patients received an injection of levocarnitine 1,000 mg 3 times weekly after hemodialysis sessions. Read More

    Evaluation of the CRUSADE Risk Score for Predicting Major Bleeding in Patients with Concomitant Kidney Dysfunction and Acute Coronary Syndromes.
    Cardiorenal Med 2017 Jun 17;7(3):179-187. Epub 2017 Feb 17.
    Division of Cardiology, University Hospital Virgen de la Arrixaca, School of Medicine, Murcia, Spain.
    Background: Kidney dysfunction (KD) has been associated with increased risk for major bleeding (MB) in patients with acute coronary syndromes (ACS) and may be in part related to an underuse of evidence-based therapies. Our aim was to assess the predictive ability of the Can Rapid risk stratification of Unstable angina patients Suppress ADverse outcomes with Early implementation of the ACC/AHA guidelines (CRUSADE) risk score in patients with concomitant ACS and chronic kidney disease.

    Methods: We conducted a retrospective analysis of a prospective registry including 1,587 ACS patients. Read More

    The Effect of Admission Renal Function on the Treatment and Outcome of Patients with Acute Coronary Syndrome.
    Cardiorenal Med 2017 Jun 17;7(3):169-178. Epub 2017 Feb 17.
    Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
    Background: Chronic kidney disease is a frequent comorbidity among patients with acute coronary syndrome (ACS). We aimed to evaluate treatment characteristics in ACS patients according to their renal function and to assess the effect of differences in therapy on clinical outcomes.

    Methods: Included were patients with ACS enrolled in the biennial Acute Coronary Syndrome Israeli Surveys (ACSIS) during 2000-2013. Read More

    Association of Growth Differentiation Factor 15 with Mortality in a Prospective Hemodialysis Cohort.
    Cardiorenal Med 2017 Feb 2;7(2):158-168. Epub 2017 Feb 2.
    Harold Simmons Center for Kidney Disease Research and Epidemiology, University of California Irvine, Orange, CA, USA.
    Background/aims: Cardiovascular disease and protein-energy wasting are among the strongest predictors of the high mortality of dialysis patients. In the general population, the novel cardiovascular and wasting biomarker, growth differentiation factor 15 (GDF15), is associated with decreased survival. However, little is known about GDF15 in dialysis patients. Read More

    Prognostic Implications of Chronic Kidney Disease on Patients Presenting with ST-Segment Elevation Myocardial Infarction with versus without Stent Thrombosis.
    Cardiorenal Med 2017 Feb 28;7(2):150-157. Epub 2017 Jan 28.
    Department of Cardiology, Tel Aviv Sourasky Medical Center Affiliated to the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
    Background: Limited data is present regarding long-term outcomes in chronic kidney disease (CKD) patients presenting with stent thrombosis (ST). We evaluated the possible implications of CKD on long-term mortality in patients presenting with ST-segment elevation myocardial infarction (STEMI) and treated with primary percutaneous coronary intervention (PCI), and its interaction with the presence of ST.

    Methods: We retrospectively studied 1,722 STEMI patients treated with primary PCI. Read More

    Lack of Diuretic Efficiency (but Not Low Diuresis) Early in An Acutely Decompensated Heart Failure Episode Is Associated with Increased 180-Day Mortality.
    Cardiorenal Med 2017 Feb 21;7(2):137-149. Epub 2017 Jan 21.
    Intensive Care Unit, Centro Hospitalar do Porto, Porto, Portugal.
    Introduction: The assessment of the amount of urine produced by the dose of administered diuretic has been proposed as the main signal of interest in diuretic responsiveness - diuretic efficiency (DE). The main aim of our study is to determine if a low DE is associated with 180-day all-cause mortality (ACM).

    Methods: During a 3-year period, we retrospectively studied patients with acutely decompensated heart failure (ADHF) and respiratory insufficiency admitted to the emergency room of a tertiary university hospital in Porto, Portugal. Read More

    Spironolactone Treatment and Effect on Survival in Chronic Heart Failure Patients with Reduced Renal Function: A Propensity-Matched Study.
    Cardiorenal Med 2017 Feb 20;7(2):128-136. Epub 2017 Jan 20.
    Department of Nephrology, Oslo University Hospital, Ullevål, Oslo, Norway.
    Background/aims: Spironolactone may be hazardous in heart failure (HF) patients with renal dysfunction due to risk of hyperkalemia and worsened renal function. We aimed to evaluate the effect of spironolactone on all-cause mortality in HF outpatients with renal dysfunction in a propensity-score-matched study.

    Methods: A total of 2,077 patients from the Norwegian Heart Failure Registry with renal dysfunction (eGFR <60 mL/min/1. Read More

    Initiation and Cessation Timing of Renal Replacement Therapy in Patients with Type 1 Cardiorenal Syndrome: An Observational Study.
    Cardiorenal Med 2017 Feb 20;7(2):118-127. Epub 2017 Jan 20.
    Department of Nephrology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
    Background/aims: Renal replacement therapy (RRT) is a rescue therapy for patients with type 1 cardiorenal syndrome (CRS) with poor prognoses. However, the optimal timing for initiation and cessation of RRT remains controversial. The purpose of this study was to determine the optimal timing of initiation and cessation of RRT for patients with type 1 CRS. Read More

    The Central Role of Endothelial Dysfunction in Cardiorenal Syndrome.
    Cardiorenal Med 2017 Feb 29;7(2):104-117. Epub 2016 Dec 29.
    Baylor Heart and Vascular Institute, TX, USA.
    Background: Endothelial dysfunction (ED) has emerged as a critical process in cardiorenal syndrome (CRS). The concept that ED is closely linked with cardiac and renal dysfunction has become an important target for CRS-related research and clinical practice.

    Summary: The sequence of events leading to ED is initiated by type I endothelial activation (almost immediately) and type II endothelial activation (over hours, days, and even months), followed by endothelial apoptosis and endothelial necrosis. Read More

    Apolipoprotein L1 Genetic Variants Are Associated with Chronic Kidney Disease but Not with Cardiovascular Disease in a Population Referred for Cardiac Catheterization.
    Cardiorenal Med 2017 Feb 29;7(2):96-103. Epub 2016 Dec 29.
    Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC, USA.
    Background: While the association between APOL1 genetic variants and chronic kidney disease (CKD) has been established, their association with cardiovascular disease (CVD) is unclear. This study sought to understand CKD and cardiovascular risk conferred by APOL1 variants in a secondary cardiovascular prevention population.

    Methods: Two risk variants in APOL1 were genotyped in African-Americans (n = 1,641) enrolled in the CATHGEN biorepository, comprised of patients referred for cardiac catheterization at Duke University Hospital, Durham, NC, USA (2001-2010). Read More

    Long-Term Percutaneous Coronary Intervention Outcomes of Patients with Chronic Kidney Disease in the Era of Second-Generation Drug-Eluting Stents.
    Cardiorenal Med 2017 Feb 9;7(2):85-95. Epub 2016 Dec 9.
    Third Division of Cardiology, Medical University of Silesia, Katowice, Poland.
    Background: The following registry (Katowice-Zabrze retrospective registry) aimed to assess the influence of a chronic kidney disease (CKD) on long-term clinical outcomes in patients undergoing percutaneous coronary intervention (PCI) using either first-generation (DES-I) or second-generation (DES-II) drug-eluting stents.

    Methods: The study group consisted of 1,908 consecutive patients, of whom 331 (17.3%) had CKD. Read More

    The Triad of Sleep Apnea, Hypertension, and Chronic Kidney Disease: A Spectrum of Common Pathology.
    Cardiorenal Med 2016 Nov 5;7(1):74-82. Epub 2016 Nov 5.
    Division of Nephrology, University of Missouri Health Science Center, Columbia, MO, USA; Nephrology Section, Harry S. Truman Veterans' Hospital, Columbia, MO, USA.
    Obstructive sleep apnea (OSA), hypertension, and chronic kidney disease (CKD) are different entities and are generally managed individually most of the time. However, CKD, OSA, and hypertension share many common risk factors and it is not uncommon to see this complex triad together. In fact, they share similar pathophysiology and have been interlinked with each other. Read More

    Asymptomatic Ventricular Arrhythmia and Clinical Outcomes in Chronic Kidney Disease: A Pilot Study.
    Cardiorenal Med 2016 Nov 28;7(1):66-73. Epub 2016 Oct 28.
    Department of Internal Medicine, Division of Nephrology, Federal University of São Paulo, São Paulo, Brazil.
    Background/aims: Ventricular arrhythmia is associated with increased risk of cardiovascular events and death in the general population. Sudden death is a leading cause of death in end-stage renal disease. We aimed at evaluating the effects of ventricular arrhythmia on clinical outcomes in patients with earlier stages of chronic kidney disease (CKD). Read More

    Fibroblast Growth Factor 23 and Hypophosphatemia: A Case of Hypophosphatemia along the Rickets-Osteomalacia Spectrum.
    Cardiorenal Med 2016 Nov 30;7(1):60-65. Epub 2016 Sep 30.
    Diabetes and Cardiovascular Center, Department of Medicine, University of Missouri, Columbia, Mo., USA; Department of Medical Pharmacology and Physiology, University of Missouri, Columbia, Mo., USA; Harry S. Truman VA Hospital, Columbia, Mo., USA.
    Phosphorus is a key component of bone, and a deficiency results in poor mineralization along with other systemic symptoms of hypophosphatemia. Various causes of hypophosphatemia with renal wasting of phosphorus have been identified. These include the Fanconi syndrome, various genetic mutations of fibroblast growth factor 23 (FGF23) handling and the sodium/phosphate cotransporter, and those due to FGF23 secretion by mesenchymal tumors. Read More

    Vasodilation and Exercise Capacity in Patients with End-Stage Renal Disease: A Prospective Proof-of-Concept Study.
    Cardiorenal Med 2016 Nov 21;7(1):50-59. Epub 2016 Sep 21.
    Department of Nephrology and Intensive Care Medicine, Berlin, Germany.
    Background: Previous data have pointed to the fact that vascular function is significantly impaired in patients with end-stage renal disease (ESRD). We aimed to better characterise vasodilation and exercise capacity in both ESRD and chronic heart failure (CHF) patients.

    Methods: A total of 30 ESRD patients (23 male; mean age 45. Read More

    The Renal Arterial Resistance Index Predicts Worsening Renal Function in Chronic Heart Failure Patients.
    Cardiorenal Med 2016 Nov 21;7(1):42-49. Epub 2016 Sep 21.
    School of Cardiology, University of Bari, Bari, Italy.
    Background/aim: The renal arterial resistance index (RRI) is a Doppler measure, which reflects abnormalities in the renal blood flow. The aim of this study was to verify the value of RRI as a predictor of worsening renal function (WRF) in a group of chronic heart failure (CHF) outpatients.

    Methods: We enrolled 266 patients in stable clinical conditions and on conventional therapy. Read More

    Oxidized Low-Density Lipoprotein Predicts the Development of Renal Dysfunction in Atrial Fibrillation.
    Cardiorenal Med 2016 Nov 16;7(1):31-41. Epub 2016 Sep 16.
    School of Medicine, University of Belgrade, Belgrade, Serbia.
    Background/aim: To investigate the role of oxidative stress (OS) in the development of chronic kidney disease (CKD) in atrial fibrillation (AF).

    Methods: We compared OS burden, determined at study inclusion as plasma concentrations of oxidized low-density lipoprotein (oxLDL), between stable AF patients (n = 256, mean age: 62.8 ± 9. Read More

    Possible Inhibitory Effect of Erythropoiesis-Stimulating Agents at the Predialysis Stage on Early-Phase Coronary Events after Hemodialysis Initiation.
    Cardiorenal Med 2016 Nov 12;7(1):21-30. Epub 2016 Aug 12.
    Department of Urology, Toujinkai Hospital, Kyoto, Japan.
    Background: We examined whether the use of erythropoiesis-stimulating agents (ESAs) to correct anemia at the predialysis stage could inhibit early-phase coronary events after hemodialysis initiation.

    Methods: We enrolled 242 patients with chronic kidney disease who had received continued medical treatments and initiated maintenance hemodialysis from 1 September 2000 to 31 December 2014 at Toujinkai Hospital. Patients with a previous history of blood transfusion or any cardiovascular events or interventions were excluded. Read More

    Matrix Metalloproteinase Neutrophil Gelatinase-Associated Lipocalin Complex Predicts Atrial Fibrillation Recurrence after Electrical Cardioversion in Obese Patients.
    Cardiorenal Med 2016 Nov 12;7(1):11-20. Epub 2016 Aug 12.
    Department of Cardiology, Medical University of Bialystok, Bialystok, Poland.
    Background: There is not much data on matrix metalloproteinase neutrophil gelatinase-associated lipocalin (MMP-NGAL) complex in patients with atrial fibrillation (AF).

    Aim: The aim of the study was to assess the value of MMP-NGAL complex in predicting AF recurrence after electrical cardioversion.

    Methods: The serum levels of NGAL, cystatin C, interleukin-6, high-sensitivity C-reactive protein, copeptin, MMP-NGAL complex, matrix metalloproteinase 2, tissue inhibitor of metalloproteinase 1, Von Willebrand factor, B-type natriuretic peptide and the urinary level of NGAL were evaluated before cardioversion. Read More

    Aging Male Spontaneously Hypertensive Rat as an Animal Model for the Evaluation of the Interplay between Contrast-Induced Acute Kidney Injury and Cardiorenal Syndrome in Humans.
    Cardiorenal Med 2016 Nov 21;7(1):1-10. Epub 2016 Jul 21.
    Baylor Heart and Vascular Institute, Dallas, Tex., USA; Department of Internal Medicine, Baylor University Medical Center, Dallas, Tex., USA; Baylor Jack and Jane Hamilton Heart and Vascular Hospital, Dallas, Tex, Tex., USA; The Heart Hospital Baylor Plano, Plano, Tex., USA.
    Background: Although there are some animal models for biomarkers of contrast-induced acute kidney injury (CI-AKI), for cardiorenal syndrome (CRS) and for acute renal failure, the interplay between CI-AKI and CRS has yet to be evaluated. Insight into the pathogenesis of CRS is urgently needed from animal models in order to foster the discovery and implementation of novel biomarkers for this disease. Specially designed animal models for type 1 and 3 CRS, particularly CI-AKI, have not yet emerged. Read More

    Brain Natriuretic Peptide and Body Fluid Composition in Patients with Chronic Kidney Disease: A Cross-Sectional Study to Evaluate the Relationship between Volume Overload and Malnutrition.
    Cardiorenal Med 2016 Aug 23;6(4):337-46. Epub 2016 Jun 23.
    Department of Nephrology, Omori Medical Center, School of Medicine, Toho University, Tokyo, Japan.
    Background/aim: Fluid volume overload occurs in chronic kidney disease (CKD), leading to the compensatory release of natriuretic peptides. However, the elevated cardiac peptides may also be associated with malnutrition as well as volume overload.

    Methods: Body fluid composition was measured in 147 patients with CKD between 2009 and 2015, and its relationship to brain natriuretic peptide (BNP) levels was examined. Read More

    Evaluation of Nephroprotective Efficacy of Hypoxic Preconditioning in Patients Undergoing Coronary Artery Bypass Surgery.
    Cardiorenal Med 2016 Aug 22;6(4):328-36. Epub 2016 Jun 22.
    National Research Tomsk Polytechnic University, Tomsk, Russian Federation.
    Background: Nonpulsatile blood flow plays an important role in the pathogenesis of renal dysfunction in patients with extracorporeal circulation. In our opinion, hypoxic preconditioning (HP) can be used to protect kidneys from postsurgical dysfunction. The aim of this study was to evaluate nephroprotective efficacy of HP in myocardial revascularization with extracorporeal circulation. Read More

    High-NaCl Diet Aggravates Cardiac Injury in Rats with Adenine-Induced Chronic Renal Failure and Increases Serum Troponin T Levels.
    Cardiorenal Med 2016 Aug 22;6(4):317-27. Epub 2016 Jun 22.
    Department of Molecular and Clinical Medicine/Nephrology, University of Gothenburg, Gothenburg, Sweden.
    Aims: To examine the effects of 2 weeks of high-NaCl diet on left ventricular (LV) morphology and serum levels of cardiac troponin T (cTnT) in rats with adenine-induced chronic renal failure (ACRF).

    Methods: Male Sprague-Dawley rats either received chow containing adenine or were pair-fed an identical diet without adenine [controls (C)]. Approximately 10 weeks after the beginning of the study, the rats were randomized to either remain on a normal NaCl diet (NNa; 0. Read More

    Association between Age at Menarche and Cardiovascular Disease Risk Factors in China: A Large Population-Based Investigation.
    Cardiorenal Med 2016 Aug 26;6(4):307-16. Epub 2016 May 26.
    Health Management Institute, Beijing China; Department of Geriatric Cardiology, Chinese PLA General Hospital, Beijing China.
    Background: The association between age at menarche (AAM) and cardiovascular disease (CVD) has previously been investigated with controversial results. The relationship between the psychological characteristic of AAM and many cardiovascular risk factors remains unclear.

    Purpose: To assess the association between AAM and CVD risk factors in a large population. Read More

    Genetic Variants in Toll-Like Receptor 4 Gene and Their Association Analysis with Estimated Glomerular Filtration Rate in Mexican American Families.
    Cardiorenal Med 2016 Aug 20;6(4):301-6. Epub 2016 May 20.
    Division of Nephrology, Department of Medicine, University of Texas Health Science Center, San Antonio, Tex, USA; South Texas Veterans Healthcare System, San Antonio, Tex, USA.
    Background/aim: Toll-like receptor 4 (TLR4) is one of the regulators of the innate immune response. Genetic variations in TLR4 have been associated with inflammatory diseases, including type 2 diabetes. However, to our knowledge, there are no reports on the role of variations in TLR4 in chronic kidney disease susceptibility. Read More

    Association of Inflammation prior to Kidney Transplantation with Post-Transplant Diabetes Mellitus.
    Cardiorenal Med 2016 Aug 18;6(4):289-300. Epub 2016 May 18.
    Division of Nephrology, Department of Medicine, Thomas Jefferson University Hospital, Pa., USA.
    Background/objective: Post-transplant diabetes mellitus (PTDM) is both common and associated with poor outcomes after kidney transplantation. Our objective was to examine relationships of uremia-associated inflammation and adiponectin with PTDM.

    Methods: Nondiabetic kidney transplant patients were enrolled with donor controls. Read More

    Predictive Value of the Mehran Score for Contrast-Induced Nephropathy after Transcatheter Aortic Valve Implantation in Patients with Aortic Stenosis.
    Cardiorenal Med 2016 Aug 5;6(4):279-88. Epub 2016 May 5.
    Department of Cardiology, Sifa University Faculty of Medicine, Izmir, Turkey.
    Background/aims: The Mehran risk score (MS) was adopted to predict the development of contrast-induced nephropathy (CIN) and includes clinical and procedural variables. In this study, we aimed to evaluate the value of MS in the prediction of CIN development after transcatheter aortic valve implantation (TAVI).

    Methods: Ninety-three patients (47 females; mean age, 77. Read More

    Impact of Cardiorenal Anemia Syndrome on Short- and Long-Term Clinical Outcomes in Patients Hospitalized with Heart Failure.
    Cardiorenal Med 2016 Aug 28;6(4):269-78. Epub 2016 Apr 28.
    Division of Cardiology, Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
    Background: Dysfunctional interplay between the heart and kidneys may lead to the development of anemia. The aim of this study was to evaluate the impact of cardiorenal anemia syndrome (CRAS) on short- and long-term outcomes among patients hospitalized with heart failure (HF).

    Methods: We enrolled 303 patients hospitalized with HF. Read More

    Beta-Blocker Use Is Associated with Higher Renal Tissue Oxygenation in Hypertensive Patients Suspected of Renal Artery Stenosis.
    Cardiorenal Med 2016 Aug 23;6(4):261-8. Epub 2016 Apr 23.
    Division of Cardiovascular Medicine, Department of Medicine, Wake Forest University School of Medicine, Winston-Salem, N.C., USA; Radiology, Wake Forest University School of Medicine, Winston-Salem, N.C., USA.
    Background: Chronic renal hypoxia influences the progression of chronic kidney disease (CKD). Blood oxygen level-dependent (BOLD) magnetic resonance (MR) is a noninvasive tool for the assessment of renal oxygenation. The impact of beta-blockers on renal hemodynamics and oxygenation is not completely understood. Read More

    Angiogenic Factors and Risks of Technique Failure and Cardiovascular Events in Patients Receiving Peritoneal Dialysis.
    Cardiorenal Med 2016 May 31;6(3):251-9. Epub 2016 Mar 31.
    First Department of Internal Medicine, Nara Medical University, Kashihara, Japan; Department of Regulatory Medicine for Blood Pressure, Nara Medical University, Kashihara, Japan.
    Background: Placental growth factor (PlGF) is a member of the vascular endothelial growth factor family that acts as a pleiotropic cytokine capable of stimulating angiogenesis and accelerating atherogenesis. Soluble fms-like tyrosine kinase-1 (sFlt-1) antagonizes PlGF action. Higher levels of PlGF and sFlt-1 have been associated with cardiovascular events in patients with chronic kidney disease, yet little is known about their relationship with adverse outcomes in patients on peritoneal dialysis (PD). Read More

    Risk Factors for Acute Kidney Injury after Cardiovascular Surgery: Evidence from 2,157 Cases and 49,777 Controls - A Meta-Analysis.
    Cardiorenal Med 2016 May 17;6(3):237-50. Epub 2016 Mar 17.
    Department of Cardiovascular Surgery, Xinqiao Hospital, Chongqing, PR China.
    Purpose: Cardiovascular surgery-associated acute kidney injury (AKI-CS) contributes to mortality and morbidity. However, risk factors accelerating its development are unclear. We identified risk factors for AKI-CS in patients with cardiopulmonary bypass in the hospital surgical intensive care unit to predict and minimize renal complication in future cardiac surgery. Read More

    Clinical and Echocardiographic Factors Associated with Right Ventricular Systolic Dysfunction in Hemodialysis Patients.
    Cardiorenal Med 2016 May 10;6(3):230-6. Epub 2016 Mar 10.
    Department of Cardiology, Hospital Central 'Dr. Ignacio Morones Prieto', San Luis Potosí, México; Faculty of Medicine, Universidad Autónoma de San Luis Potosí, San Luis Potosí, México.
    Background: Chronic kidney disease is a disorder of epidemic proportions that impairs cardiac function. Cardiovascular diseases are the leading cause of death in hemodialysis patients, and the understanding of new nontraditional predictors of mortality could improve their outcomes. Right ventricular systolic dysfunction (RVSD) has recently been recognized as a predictor of cardiovascular death in heart failure and hemodialysis patients. Read More

    Risk Factors for Acute Kidney Injury after Coronary Artery Bypass Surgery and Its Detection Using Neutrophil Gelatinase-Associated Lipocalin.
    Cardiorenal Med 2016 May 10;6(3):216-29. Epub 2016 Mar 10.
    Division of Nephrology, Department of Internal Medicine, Meram School of Medicine, Necmettin Erbakan University, Konya, Turkey.
    Introduction: Acute kidney injury (AKI) is an important complication of cardiac surgery due to its high mortality. The aim of the present study was to detect the factors leading to AKI in patients who underwent coronary artery bypass surgery (CABS) and also to determine the optimal timing for detecting AKI using the biomarker neutrophil gelatinase-associated lipocalin (NGAL).

    Materials And Methods: The records of 375 patients who underwent CABS were reviewed in this case-control study. Read More

    Circadian Blood Pressure Rhythm Is Changed by Improvement in Hypoalbuminemia and Massive Proteinuria in Patients with Minimal Change Nephrotic Syndrome.
    Cardiorenal Med 2016 May 1;6(3):209-15. Epub 2016 Mar 1.
    Division of Nephrology and Hypertension, Yokohama City University Center Hospital, Yokohama, Japan.
    Background: Proteinuria and nighttime blood pressure (BP) elevation are notable risk markers of chronic kidney disease and correlate closely with each other. However, daily urinary protein excretion (UPE) always fluctuates. In patients with minimal change nephrotic syndrome (MCNS), serum albumin concentrations (SAC) decrease but fluctuate less than UPE. Read More

    Psychological Distress and Hypertension: Results from the National Health Interview Survey for 2004-2013.
    Cardiorenal Med 2016 May 25;6(3):198-208. Epub 2016 Feb 25.
    Division of Endocrinology, Department of Medicine, SUNY-Downstate/Kings County Hospital Center, Brooklyn, N.Y., USA.
    Background/aims: Psychological conditions are increasingly linked with cardiovascular disorders. We aimed to examine the association between psychological distress and hypertension.

    Methods: We used data from the National Health Interview Survey for 2004-2013. Read More

    Serum Uric Acid Levels and Renal Impairment among ST-Segment Elevation Myocardial Infarction Patients Undergoing Primary Percutaneous Intervention.
    Cardiorenal Med 2016 May 25;6(3):191-7. Epub 2016 Feb 25.
    Department of Cardiology, Tel Aviv Sourasky Medical Center affiliated to the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
    Background: Elevated serum uric acid (UA) levels are associated with adverse outcomes in ST-segment elevation myocardial infarction (STEMI) patients undergoing primary percutaneous coronary intervention (PCI). However, the relation between UA and acute kidney injury (AKI) in this population is unclear. We evaluated the effect of elevated UA levels on the risk to develop AKI among consecutive STEMI patients treated with primary PCI. Read More

    Plasma Neutrophil Gelatinase-Associated Lipocalin Reflects Both Inflammation and Kidney Function in Patients with Myocardial Infarction.
    Cardiorenal Med 2016 May 25;6(3):180-90. Epub 2016 Feb 25.
    The Medical Research Laboratories, Department of Clinical Medicine, Faculty of Health Sciences, Aarhus University, Aarhus, Denmark.
    Background/aims: Neutrophil gelatinase-associated lipocalin (NGAL) has emerged as a marker for acute kidney injury and cardiovascular outcome. However, the relative importance of inflammation versus kidney function on plasma NGAL levels is uncertain, making the interpretation of plasma NGAL unclear. Accordingly, we investigated the relationship between plasma NGAL, inflammation and kidney function in patients with myocardial infarction (MI). Read More

    Determinants of Mortality in Patients with Chronic Kidney Disease Undergoing Percutaneous Coronary Intervention.
    Cardiorenal Med 2016 May 19;6(3):169-79. Epub 2016 Feb 19.
    Department of Cardiology, King's College London, London, UK.
    Background: Renal impairment is a known predictor of mortality in both the general population and in patients with cardiac disease. The aim of this study was to evaluate factors that determine mortality in patients with chronic kidney disease (CKD) who have undergone percutaneous coronary intervention (PCI).

    Methods: In this study we included 293 consecutive patients with CKD who underwent PCI between 1st January 2007 and 30th September 2012. Read More

    Elevated Fibroblast Growth Factor 23 Concentration: Prediction of Mortality among Chronic Kidney Disease Patients.
    Cardiorenal Med 2015 Dec 4;6(1):73-82. Epub 2015 Nov 4.
    Center for Research and Medical Consultation, University of Dammam, Dammam, Saudi Arabia.
    Background: The osteocyte-derived hormone, fibroblast growth factor 23 (FGF23), regulates the phosphorus metabolism and suppresses 1,25-dihydroxyvitamin D production, thereby mitigating hyperphosphatemia in patients with renal disorders. An elevated FGF23 level is suggested to be an early biomarker of altered phosphorus metabolism in the initial stages of chronic kidney disease (CKD) and acts as a strong predictor of mortality in dialysis patients. In the Saudi population, there is no report on the FGF23 level in CKD patients to date. Read More

    The Role of Congestion in Cardiorenal Syndrome Type 2: New Pathophysiological Insights into an Experimental Model of Heart Failure.
    Cardiorenal Med 2015 Dec 31;6(1):61-72. Epub 2015 Oct 31.
    Internal Medicine Unit, Sant'Antonio Hospital Padua, Padua, Vicenza, Italy.
    Background: In cardiorenal syndrome type 2 (CRS2), the role of systemic congestion in heart failure (HF) is still obscure. We studied a model of CRS2 [monocrotaline (MCT)-treated rats] secondary to pulmonary hypertension and right ventricular (RV) failure in order to evaluate the contribution of prevalent congestion to the development of kidney injury.

    Methods: Ten animals were treated with MCT for 4 weeks until they developed HF. Read More

    Extracorporeal Membrane Oxygenation and the Kidney.
    Cardiorenal Med 2015 Dec 17;6(1):50-60. Epub 2015 Oct 17.
    Department of Nephrology, Dialysis and Transplantation, International Renal Research Institute, San Bortolo Hospital, Vicenza, Italy.
    Background: Extracorporeal membrane oxygenation (ECMO) is an effective therapy for patients with reversible cardiac and/or respiratory failure. Acute kidney injury (AKI) often occurs in patients supported with ECMO; it frequently evolves into chronic kidney damage or end-stage renal disease and is associated with a reported 4-fold increase in mortality rate. Although AKI is generally due to the hemodynamic alterations associated with the baseline disease, ECMO itself may contribute to maintaining kidney dysfunction through several mechanisms. Read More

    Association of Body Mass Index with Clinical Outcomes in Non-Dialysis-Dependent Chronic Kidney Disease: A Systematic Review and Meta-Analysis.
    Cardiorenal Med 2015 Dec 16;6(1):37-49. Epub 2015 Oct 16.
    Harold Simmons Center for Kidney Disease Research and Epidemiology, Division of Nephrology and Hypertension, University of California Irvine Medical Center, Orange, Calif., USA; Department of Population Health and Disease Prevention, Program in Public Health, Calif., USA; Veterans Affairs Long Beach Healthcare System, Long Beach, Calif., USA; Department of Epidemiology, UCLA School of Public Health, Los Angeles, Calif., USA.
    Background: Previous studies have not shown a consistent link between body mass index (BMI) and outcomes such as mortality and kidney disease progression in non-dialysis-dependent chronic kidney disease (CKD) patients. Therefore, we aimed to complete a systematic review and meta-analysis study on this subject.

    Methods: We searched MEDLINE, EMBASE, Web of Science, Cumulative Index to Nursing and Allied Health Literature (CINAHL), and Cochrane Central Register of Controlled Trials (CENTRAL), and screened 7,123 retrieved studies for inclusion. Read More

    Renalase and Biomarkers of Contrast-Induced Acute Kidney Injury.
    Cardiorenal Med 2015 Dec 19;6(1):25-36. Epub 2015 Sep 19.
    First Department of Cardiology, School of Medicine in Katowice, Medical University of Silesia, Katowice, Poland.
    Background: Contrast-induced acute kidney injury (CI-AKI) remains one of the crucial issues related to the development of invasive cardiology. The massive use of contrast media exposes patients to a great risk of contrast-induced nephropathy and chronic kidney disease development, and increases morbidity and mortality rates. The serum creatinine concentration does not allow for a timely and accurate CI-AKI diagnosis; hence numerous other biomarkers of renal injury have been proposed. Read More

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