272 results match your criteria Cardiorenal medicine[Journal]


Customization of Peritoneal Dialysis in Cardiorenal Syndrome by Optimization of Sodium Extraction.

Cardiorenal Med 2019 Feb 6;9(2):117-124. Epub 2019 Feb 6.

Department of Nephrology, San Bortolo Hospital, Vicenza, Italy.

Background: Peritoneal dialysis (PD) has emerged as a mechanistically relevant therapeutic option for patients with heart failure (HF), volume overload, and varying degrees of renal dysfunction (i.e., chronic cardiorenal syndrome). Read More

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http://dx.doi.org/10.1159/000495703DOI Listing
February 2019
1 Read

NT-proBNP in the Prognosis of Death or Need for Renal Replacement Therapy in Patients with Stage 3-5 Chronic Kidney Disease.

Cardiorenal Med 2019 Feb 6;9(2):125-134. Epub 2019 Feb 6.

Department of Internal Medicine and Cardiology, Medical University of Warsaw, Warsaw, Poland.

Background: The risk of cardiovascular (CV) complications is much greater in patients with chronic kidney disease (CKD). The aim of this study was to assess predictors of mortality, renal failure progression, and the need for dialysis in patients with CKD.

Methods: The study group consisted of 70 patients with stage 3-5 CKD, followed up on average for 33. Read More

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http://dx.doi.org/10.1159/000496238DOI Listing
February 2019
1 Read

Biomarkers of Inflammation, Fibrosis, and Acute Kidney Injury in Patients with Heart Failure with and without Left Ventricular Assist Device Implantation.

Cardiorenal Med 2019 Jan 30;9(2):108-116. Epub 2019 Jan 30.

Division of Cardiovascular Surgery, Peter Munk Cardiac Centre, University Health Network, University of Toronto, Toronto, Ontario,

Background/aims: Renal dysfunction or renal failure is a common complication in left ventricular assist device (LVAD) recipients and is associated with reduced survival. To date, serum creatinine and glomerular filtration rate (GFR) are used for the evaluation of kidney function. However, serum creatinine and GFR have limitations. Read More

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http://dx.doi.org/10.1159/000494090DOI Listing
January 2019

Outcomes of Moderate-to-Severe Acute Kidney Injury following Left Ventricular Assist Device Implantation.

Cardiorenal Med 2019 Jan 23;9(2):100-107. Epub 2019 Jan 23.

Center for Advanced Heart and Lung Disease, Baylor University Medical Center, Dallas, Texas,

Background: Although acute kidney injury (AKI) is a common complication following cardiac surgery, less is known about the occurrence and consequences of moderate/severe AKI following left ventricular assist device (LVAD) implantation.

Methods: All patients who had an LVAD implanted at our center from 2008 to 2016 were reviewed to determine the incidence of, and risk factors for, moderate/severe (stage 2/3) AKI and to compare postoperative complications and mortality rates between those with and those without moderate/severe AKI.

Results: Of 246 patients, 68 (28%) developed moderate/severe AKI. Read More

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http://dx.doi.org/10.1159/000492476DOI Listing
January 2019

Prolonged Hyperglycemia and Renal Failure after Primary Percutaneous Coronary Intervention.

Cardiorenal Med 2019 Jan 11;9(2):92-99. Epub 2019 Jan 11.

Department of Cardiology, Tel Aviv Sourasky Medical Center affiliated to the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv,

Background: There are limited data regarding the effect of long-standing hyperglycemia on the occurrence of acute kidney injury (AKI) in ST segment elevation myocardial infarction (STEMI) patients undergoing primary percutaneous coronary intervention (PCI).

Methods: We retrospectively studied 723 STEMI patients undergoing primary PCI. Patients were stratified into two groups according to glycated hemoglobin (HbA1c) levels as a marker of prolonged hyperglycemia: those with HbA1c < 7% and those with HbA1c ≥7%. Read More

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http://dx.doi.org/10.1159/000495704DOI Listing
January 2019
2 Reads

Echocardiographic and Hemodynamic Parameters Associated with Diminishing Renal Filtration among Patients with Heart Failure with Preserved Ejection Fraction.

Cardiorenal Med 2018 Dec 13;9(2):83-91. Epub 2018 Dec 13.

Department of Medicine, Einstein Medical Center, Philadelphia, Pennsylvania, USA.

Background: Renal dysfunction is an important predictor of poor outcomes in patients with heart failure with preserved ejection fraction (HFpEF). Right ventricular (RV) dysfunction is implicated as one of the explanations for worsening renal function in cardiorenal syndrome. Novel right heart catheterization (RHC) parameters such as pulmonary artery pulsatility index (PAPi) and right atrial to pulmonary capillary wedge pressure ratio (RA:PCWP) have been found as predictors of RV dysfunction. Read More

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http://dx.doi.org/10.1159/000494089DOI Listing
December 2018
4 Reads

Individualized Hemodialysis Treatment: A Perspective on Residual Kidney Function and Precision Medicine in Nephrology.

Cardiorenal Med 2018 Dec 11;9(2):69-82. Epub 2018 Dec 11.

Harold Simmons Center of Kidney Disease Research and Epidemiology, Division of Nephrology and Hypertension, University of California Irvine School of Medicine, Orange, California,

Background: Residual kidney function (RKF) is often expected to inevitably and rapidly decline among hemodialysis patients and, hence, has been inadvertently ignored in clinical practice. The importance of RKF has been revisited in some recent studies. Given that patients with end-stage renal disease now tend to initiate maintenance hemodialysis therapy with higher RKF levels, there seem to be important opportunities for incremental hemo-dialysis by individualizing the dose and frequency according to their RKF levels. Read More

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http://dx.doi.org/10.1159/000494808DOI Listing
December 2018
3 Reads

Impaired Left Ventricular Global Longitudinal Strain among Patients with Chronic Kidney Disease and End-Stage Renal Disease and Renal Transplant Recipients.

Cardiorenal Med 2019 28;9(1):61-68. Epub 2018 Nov 28.

Nephrology, Dialysis, and Transplantation, University of Genoa, Policlinico San Martino, Genoa,

Background: Although heart failure is the most prevalent cardiovascular disease associated with adverse outcome in chronic kidney disease (CKD) and after kidney transplantation, left ventricular (LV) systolic function is often preserved in renal patients. The aim of this study was to evaluate global longitudinal strain (GLS), which is reportedly a more accurate tool for detecting subclinical LV systolic dysfunction, in patients with various degrees of renal function impairment, including kidney transplant recipients (KTRs).

Methods: This prospective study evaluated demographic, clinical, and ultrasound data, including the assessment of LV GLS and mitral E peak velocity and averaged ratio of mitral to myocardial early velocities (E/e'), of 70 consecutive renal patients (20 with stage 2-4 CKD, 25 with end-stage renal disease on hemodialysis [HD], and 25 KTRs). Read More

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http://dx.doi.org/10.1159/000494065DOI Listing
November 2018
1 Read

In-Hospital Mortality and Major Adverse Cardiovascular Events after Kidney Transplantation in the United States.

Cardiorenal Med 2019 14;9(1):51-60. Epub 2018 Nov 14.

Division of Nephrology, Department of Medicine, Einstein Medical Center, Philadelphia, Pennsylvania, USA.

Background: Kidney transplantation (KT) is the treatment of choice for end-stage kidney disease. Cardiovascular disease is a major determinant of morbidity and mortality in patients with KT. Temporal trends in perioperative cardiovascular outcomes after KT are understudied, especially in light of an aging KT waitlist population. Read More

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https://www.karger.com/Article/FullText/492731
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http://dx.doi.org/10.1159/000492731DOI Listing
November 2018
14 Reads

Derived Subendocardial Viability Ratio and Cardiovascular Events in Patients with Chronic Kidney Disease.

Cardiorenal Med 2019 8;9(1):41-50. Epub 2018 Nov 8.

Medical Faculty, University of Maribor, Maribor, Slovenia.

Background: Chronic kidney disease (CKD) is a well-known mortality risk factor. The subendocardial viability ratio (SEVR) is one of the pulse wave analysis parameters that constitutes a non-invasive measure of coronary perfusion. We aimed to assess the prognostic value of the SEVR for cardiovascular outcome in non-dialysis CKD patients. Read More

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https://www.karger.com/Article/FullText/493512
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http://dx.doi.org/10.1159/000493512DOI Listing
November 2018
9 Reads

Enteral Baicalin, a Flavone Glycoside, Reduces Indicators of Cardiac Surgery-Associated Acute Kidney Injury in Rats.

Cardiorenal Med 2019 7;9(1):31-40. Epub 2018 Nov 7.

Background/aims: Cardiac surgery-associated acute kidney injury (CSA-AKI) is one of the most common postoperative complications in intensive care medicine. Baicalin has been shown to have anti-inflammatory and antioxidant roles in various disorders. We aimed to test the protective effects of baicalin on CSA-AKI using a rat model. Read More

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https://www.karger.com/Article/FullText/492159
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http://dx.doi.org/10.1159/000492159DOI Listing
November 2018
6 Reads

Early Left Ventricular Dysfunction Detected by Speckle Tracking in Long-Term Hemodialysis Patients with Valvular Calcification.

Cardiorenal Med 2019 31;9(1):22-30. Epub 2018 Oct 31.

Purpose: Cardiac valve calcification (VC) is very common in patients on hemodialysis. However, the definite effect of VC on left ventricular (LV) geometry and function in this population is unknown, especially when LV ejection fraction (LVEF) is normal. The aim of this study was to determine the effect of VC on LV geometry and function in long-term hemodialysis patients by conventional echocardiography and two-dimensional speckle tracking echocardiography (2D-STE). Read More

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https://www.karger.com/Article/FullText/491679
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http://dx.doi.org/10.1159/000491679DOI Listing
October 2018
11 Reads

Chronic Hyperkalemia in Cardiorenal Patients: Risk Factors, Diagnosis, and New Treatment Options.

Cardiorenal Med 2019 25;9(1):8-21. Epub 2018 Oct 25.

Department of Nephrology and Dialysis, ASTT Lariana, S. Anna Hospital, Como, Italy.

Chronic hyperkalemia (HK) is a serious medical condition that often manifests in patients with chronic kidney disease (CKD) and heart failure (HF) leading to poor outcomes and necessitating careful management by cardionephrologists. CKD, HF, diabetes, and renin-angiotensin-aldosterone system inhibitors use is known to induce HK. Current therapeutic options are not optimal, as pointed out by a large number of CKD and HF patients with HK. Read More

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https://www.karger.com/Article/FullText/493395
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http://dx.doi.org/10.1159/000493395DOI Listing
October 2018
13 Reads

Hepatorenal Syndrome or Hepatocardiorenal Syndrome: Revisiting Basic Concepts in View of Emerging Data.

Cardiorenal Med 2019 17;9(1):1-7. Epub 2018 Sep 17.

Department of Nephrology, San Bortolo Hospital, Vicenza, Italy.

Background: Accumulating evidence on the pathophysiology of hepatorenal syndrome has challenged the conventional model of liver-kidney connection. While liver cirrhosis is traditionally considered the origin of a cascade of pathophysiologic mechanisms directly affecting other organs such as the kidney, emerging data point to the heart as the potential mediator of the untoward renal effects.

Summary: Herein, we briefly review the often-overlooked contribution of the heart to circulatory dysfunction in hepatorenal syndrome and put forward evidence arguing for the involvement of systemic inflammation and endothelial dysfunction in this setting. Read More

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https://www.karger.com/Article/FullText/492791
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http://dx.doi.org/10.1159/000492791DOI Listing
September 2018
17 Reads

Impact of KDIGO-Defined Acute Kidney Injury on Mortality after Percutaneous Coronary Intervention for Acute Myocardial Infarction.

Cardiorenal Med 2018 17;8(4):332-339. Epub 2018 Sep 17.

Department of Nephrology, University Medical Center Maribor, Maribor, Slovenia.

Background: There are limited data regarding the incidence and long-term impact of acute kidney injury (AKI) according to the KDIGO guidelines on the outcome in patients with myocardial infarction (MI) treated with percutaneous coronary intervention (PCI). The aim of the study was to evaluate the prevalence of AKI, as classified by the KDIGO criteria, and its association with long-term mortality.

Methods: Data from 5,859 MI patients undergoing PCI at our institution were analyzed. Read More

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https://www.karger.com/Article/FullText/492287
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http://dx.doi.org/10.1159/000492287DOI Listing
September 2018
3 Reads

Levels of Proinflammatory Cytokines, Oxidative Stress, and Tissue Damage Markers in Patients with Acute Heart Failure with and without Cardiorenal Syndrome Type 1.

Cardiorenal Med 2018 11;8(4):321-331. Epub 2018 Sep 11.

Department of Nephrology, Dialysis and Transplantation, San Bortolo Hospital, Vicenza, Italy.

Background: Cardiorenal syndrome type 1 (CRS type 1) is characterized by a rapid worsening of cardiac function leading to acute kidney injury (AKI). Inflammation and oxidative stress seem to play a pivotal role in its pathophysiology. In this in vivo study, we examined the putative role of inflammation and humoral markers in the pathogenesis of the CRS type 1. Read More

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http://dx.doi.org/10.1159/000492602DOI Listing
September 2018
3 Reads

Urine Cofilin-1 Detection for Predicting Type 1 Cardiorenal Syndrome in the Coronary Care Unit: A Gold Nanoparticle- and Laser-Based Approach.

Cardiorenal Med 2018 17;8(4):302-310. Epub 2018 Aug 17.

College of Medicine, Chang Gung University, Taoyuan, Taiwan.

Background: Type 1 cardiorenal syndrome (CRS) is a severe complication for acute decompensated heart failure patients. This study aimed at evaluating the feasibility of using the gold nanoparticle-based localized surface plasmon-coupled fluorescence biosensor (LSPCFB) to detect urine cofilin-1 as a biomarker for predicting CRS among patients in the coronary care unit (CCU).

Methods: A total of 44 patients were included with prospectively collected urine and blood samples. Read More

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http://dx.doi.org/10.1159/000490927DOI Listing
August 2018
2 Reads

Relationship between Plasma Proprotein Convertase Subtilisin/Kexin Type 9 and Estimated Glomerular Filtration Rate in the General Chinese Population.

Cardiorenal Med 2018 17;8(4):311-320. Epub 2018 Aug 17.

Background: Elevated levels of proprotein convertase subtilisin/kexin type 9 (PCSK9) have been reported to be related to dyslipidemia, including patients with kidney dysfunction. However, its association with estimated glomerular filtration rate (eGFR) in individuals with normal serum creatinine (SCr) has not been determined.

Methods: A total of 2,089 subjects with normal SCr and without lipid-lowering treatment were consecutively enrolled in this study. Read More

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http://dx.doi.org/10.1159/000490766DOI Listing
August 2018
3 Reads

Cardionephrology: Proposal for a Futuristic Educational Approach to a Contemporary Need.

Cardiorenal Med 2018 8;8(4):296-301. Epub 2018 Aug 8.

Department of Nephrology, San Bortolo Hospital, Vicenza, Italy.

The field of cardiorenal medicine is vast, rapidly expanding, and complex. Conventional nephrology training programs provide the fellows with the necessary core knowledge to provide general care for patients with renal and cardiovascular diseases. However, there is a need for focused training of interested physicians to master the specialized aspects of these exceedingly common clinical scenarios and optimize the care of such patients. Read More

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http://dx.doi.org/10.1159/000490744DOI Listing
August 2018
4 Reads

Detection of Atherosclerotic Cardiovascular Disease in Patients with Advanced Chronic Kidney Disease in the Cardiology and Nephrology Communities.

Cardiorenal Med 2018 3;8(4):285-295. Epub 2018 Aug 3.

New York University School of Medicine, New York, New York, USA.

Background: Atherosclerotic cardiovascular disease (ASCVD) is a leading cause of morbidity and mortality among patients with chronic kidney disease (CKD) with a glomerular filtration rate of < 60 mL/min/1.73 m2 body surface area. The availability of high-quality randomized controlled trial data to guide management for the population with CKD and ASCVD is limited. Read More

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http://dx.doi.org/10.1159/000490768DOI Listing
August 2018
4 Reads

Hyponatremia in Acute Heart Failure in Relation to Hematocrit Levels: Clinical Relevance and Prognostic Implication.

Cardiorenal Med 2018 25;8(4):259-270. Epub 2018 Jul 25.

Cardiovascular Diseases Unit, Department of Internal Medicine, University of Siena, Siena, Italy.

Background: Hyponatremia is the most common electrolyte abnormality found in hospitalized patients with acute heart failure (AHF) and is related to poor prognosis. This study sought to evaluate: (1) the different prognostic impact of dilutional versus depletional hyponatremia, evaluating short- and long-term outcome; (2) the relationship between both types of hyponatremia and intravenous furosemide dose, renal function changes, and persistent congestion at discharge.

Methods: This retrospective single-center study included 233 consecutive patients with a primary diagnosis of AHF. Read More

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https://www.karger.com/Article/FullText/490767
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http://dx.doi.org/10.1159/000490767DOI Listing
July 2018
4 Reads

Left Ventricular Strain and Dyssynchrony in Young and Middle-Aged Peritoneal Dialysis Patients and Healthy Controls: A Case-Matched Study.

Cardiorenal Med 2018 25;8(4):271-284. Epub 2018 Jul 25.

Department of Cardiology, The Second Affiliated Hospital of Soochow University, Suzhou, China.

Background: This study aimed to evaluate the role of two-dimensional speckle-tracking imaging (2D-STI) and myocardial layer-specific analysis in evaluating early left ventricular (LV) myocardial function and systolic dyssynchrony in young and middle-aged uremic patients undergoing peritoneal dialysis (PD).

Methods: We enrolled 31 PD patients aged ≤65 years with preserved LV ejection fraction (LVEF, ≥54%) as the PD group and 49 age-matched healthy people as the control group. Echocardiography was used to assess the left atrial diameter index (LADI, LAD/BSA), LV mass index (LVMI), LVEF, peak early diastolic velocity/late diastolic velocity (E/A) (measured by pulsed Doppler), and peak early diastolic velocity (by pulsed Doppler)/peak velocity of the early diastolic wave (by pulsed-wave tissue Doppler) (E/e'). Read More

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http://dx.doi.org/10.1159/000490395DOI Listing
July 2018
18 Reads

CXCL12 in Patients with Chronic Kidney Disease and Healthy Controls: Relationships to Ambulatory 24-Hour Blood Pressure and Echocardiographic Measures.

Cardiorenal Med 2018 18;8(3):249-258. Epub 2018 Jul 18.

Chair and Department of Cardiology, Hypertension and Internal Medicine, Medical University of Warsaw, Warsaw, Poland.

Background/aims: Chronic kidney disease is a pro-inflammatory condition where the interplay between different regulatory pathways and immune cells mediates an unfavorable remodeling of the vascular wall and myocardial hypertrophy. These mechanisms include the action of CXCL12. The aim of this study is to evaluate the association between serum CXCL12 with left ventricular hypertrophy (LVH) and blood pressure control in chronic kidney disease (CKD) patients. Read More

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http://dx.doi.org/10.1159/000490396DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6170919PMC
July 2018
12 Reads

Plasma Level of Retinol-Binding Protein 4, N-Terminal proBNP and Renal Function in Older Patients Hospitalized for Heart Failure.

Cardiorenal Med 2018 4;8(3):237-248. Epub 2018 Jul 4.

Pathophysiology Unit, Department of Pathophysiology, School of Medicine in Katowice, Medical University of Silesia, Katowice, Poland.

Background/aim: Elevated plasma concentration of retinol-binding protein 4 (RBP4) has recently emerged as a potential new risk factor for cardiovascular diseases, including hypertension (HT) and coronary artery disease (CAD). Limited data suggest that RBP4 promotes inflammatory damage to cardiomyocytes and participates in the development of heart failure (HF). This study aimed to analyze the relationship between concentrations of plasma RBP4 and serum N-terminal proBNP (NT-proBNP), a powerful biomarker of left ventricle dysfunction, in the older Polish population. Read More

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http://dx.doi.org/10.1159/000489403DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6170924PMC
July 2018
10 Reads

Differential Impact of Chronic Kidney Disease on Coronary Calcification and Atherosclerosis in Asymptomatic Individuals with or without Diabetes: Analysis from a Coronary Computed Tomographic Angiography Registry.

Cardiorenal Med 2018 29;8(3):228-236. Epub 2018 Jun 29.

Cardiovascular Center and Cardiology Division, Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul, Republic of Korea.

Aim: The aim of this study was to assess the combined effects of chronic kidney disease (CKD) and diabetes on the extent and developmental pattern of coronary artery disease (CAD).

Methods: A total of 3,017 self-referred asymptomatic individuals without known CAD who underwent 64-channel dual-source coronary computed tomography angiography between 2006 and 2010 were enrolled. The patients were divided into six groups based on their diabetes status (nondiabetic or diabetic) and estimated glomerular filtration rate (eGFR) (eGFR > 90 mL/min/1. Read More

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http://dx.doi.org/10.1159/000489097DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6170925PMC
June 2018
8 Reads

Metabolic Syndrome and the Iodine-Dose/Creatinine Clearance Ratio as Determinants of Contrast-Induced Acute Kidney Injury.

Cardiorenal Med 2018 15;8(3):217-227. Epub 2018 Jun 15.

Department of Cardiovascular Medicine, Rasoul-e-Akram General Hospital, IUMS, Tehran, Iran.

Background: Finding patients at risk of developing contrast-induced acute kidney injury (CI-AKI) is important because of its associated complications. In the present study, the contribution of different variables, such as the presence of metabolic syndrome (MetS), the volume creatinine clearance (V/CrCl) ratio, the iodine-dose (I-dose)/CrCl ratio, or hypertension, to CI-AKI was evaluated.

Methods: A total of 255 patients undergoing elective coronary angiography with or without intervention were enrolled and divided into a MetS and a control group. Read More

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http://dx.doi.org/10.1159/000488374DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6170904PMC
June 2018
17 Reads

Determinants of Monocyte Apoptosis in Cardiorenal Syndrome Type 1.

Cardiorenal Med 2018 30;8(3):208-216. Epub 2018 May 30.

Department of Nephrology, Dialysis and Transplant, San Bortolo Hospital, Vicenza, Italy.

Background: Cardiorenal syndrome type 1 (CRS type 1) is characterized by a rapid worsening of cardiac function leading to acute kidney injury (AKI). Its pathophysiology is complex and not completely understood. In this study, we examined the role of apoptosis and the caspase pathways involved. Read More

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http://dx.doi.org/10.1159/000488949DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6170906PMC
May 2018
11 Reads

Epicardial Fat Thickness in Patients with Autosomal Dominant Polycystic Kidney Disease.

Cardiorenal Med 2018 3;8(3):199-207. Epub 2018 May 3.

Unit of Secondary Hypertension, Department of Internal Medicine and Medical Specialties, Sapienza University of Rome, Rome, Italy.

Introduction: Autosomal dominant polycystic kidney disease (ADPKD) is associated with early organ damage such as left ventricular hypertrophy and higher cardiovascular risk when compared to essential hypertension (EH). Epicardial adipose tissue (EAT) is a new cardiovascular risk factor, but its role and correlation with left ventricular mass (LVM) in ADPKD is unknown.

Aims: we sought to investigate whether EAT is higher and related to LVM indexed by body surface area (LVMi) in hypertensive patients with ADPKD compared to those with EH. Read More

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http://dx.doi.org/10.1159/000488064DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6167706PMC
May 2018
5 Reads

ω-3 Polyunsaturated Fatty Acid Postconditioning Protects the Isolated Perfused Rat Heart from Ischemia-Reperfusion Injury.

Cardiorenal Med 2018 11;8(3):173-182. Epub 2018 Apr 11.

Department of Pathology, 421 Hospital of PLA, Guangzhou, China.

Aims: This study aimed to evaluate the cardioprotective effects of ω-3 polyunsaturated fatty acids (PUFAs) postconditioning against ischemia-reperfusion (I/R) injury.

Methods: Sixty Sprague-Dawley rats were randomly divided into 4 groups (n = 15 for each) and used to generate the Langendorff isolated perfused rat heart model. The sham group received a continuous perfusion of 150 min. Read More

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http://dx.doi.org/10.1159/000487490DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6167714PMC
April 2018
5 Reads

Pulmonary Catherization Data Correlate Poorly with Renal Function in Heart Failure.

Cardiorenal Med 2018 10;8(3):183-191. Epub 2018 Apr 10.

School of Public Health, The University of Texas Health Science Center at Houston, Houston, Texas, USA.

Background: The mechanisms of renal dysfunction in heart failure are poorly understood. We chose to explore the relationship of cardiac filling pressures and cardiac index (CI) in relation to renal dysfunction in advanced heart failure.

Objectives: To determine the relationship between renal function and cardiac filling pressures using the United Network of Organ Sharing (UNOS) pulmonary artery catherization registry. Read More

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http://dx.doi.org/10.1159/000487203DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6170923PMC
April 2018
5 Reads

Preeclampsia as a Form of Type 5 Cardiorenal Syndrome: An Underrecognized Entity in Women's Cardiovascular Health.

Cardiorenal Med 2018 4;8(2):160-172. Epub 2018 Apr 4.

Baylor University Medical Center, Baylor Heart and Vascular Institute, Dallas, Texas, USA.

Background: Preeclampsia is a multisystem vascular disorder of pregnancy that remains a leading cause of maternal and fetal morbidity and mortality. Preeclampsia remains an underrecognized risk factor for future cardiovascular and kidney disease in women and represents the confluence of preexisting vascular risk factors with superimposed endothelial injury from placental mediated anti-angiogenic factors.

Summary: This review highlights the close relationship between preeclampsia and future cardiovascular and kidney disease. Read More

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http://dx.doi.org/10.1159/000487646DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5968275PMC
April 2018
7 Reads

Relevance of B-Lines on Lung Ultrasound in Volume Overload and Pulmonary Congestion: Clinical Correlations and Outcomes in Patients on Hemodialysis.

Cardiorenal Med 2018 29;8(2):83-91. Epub 2017 Nov 29.

Background: Volume overload in patients on hemodialysis (HD) is an independent risk factor for cardiovascular mortality. B-lines detected on lung ultrasound (BLUS) assess extravascular lung water. This raises interest in its utility for assessing volume status and cardiovascular outcomes. Read More

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http://dx.doi.org/10.1159/000476000DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5968278PMC
November 2017
10 Reads

High Right Ventricular Stroke Work Index Is Associated with Worse Kidney Function in Patients with Heart Failure with Preserved Ejection Fraction.

Cardiorenal Med 2018 28;8(2):123-129. Epub 2018 Feb 28.

Cardiology Division, Department of Internal Medicine, Einstein Medical Center, Philadelphia, Pennsylvania, USA.

Background: In patients with heart failure with preserved ejection fraction (HFpEF), worse kidney function is associated with worse overall cardiac mechanics. Right ventricular stroke work index (RVSWI) is a parameter of right ventricular function. The aim of our study was to determine the relationship between RVSWI and glomerular filtration rate (GFR) in patients with HFpEF. Read More

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http://dx.doi.org/10.1159/000486629DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5968285PMC
February 2018
7 Reads

Impact of Chronic Kidney Disease on Cardiovascular and Renal Events in Patients Undergoing Percutaneous Coronary Intervention with Everolimus-Eluting Stent: Risk Stratification with C-Reactive Protein.

Cardiorenal Med 2018 27;8(2):151-159. Epub 2018 Mar 27.

Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan.

Background: Chronic kidney disease (CKD) and inflammation play critical roles in atherosclerosis. There is limited evidence regarding the relationship between CKD and patients receiving second-generation drug-eluting stents for coronary artery disease.

Objective: This study aimed to investigate the effect of CKD on cardiovascular and renal events in patients undergoing percutaneous coronary intervention (PCI) with everolimus-eluting stents (EES). Read More

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http://dx.doi.org/10.1159/000486971DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5968296PMC
March 2018
14 Reads

The Effect of Mitochondrial Complex I-Linked Respiration by Isoflurane Is Independent of Mitochondrial Nitric Oxide Production.

Cardiorenal Med 2018 1;8(2):113-122. Epub 2018 Feb 1.

Institute of Clinical Medicine Research, Suzhou Hospital (West District) Affiliated to Nanjing Medical University, Suzhou Science and Technology Town Hospital, Suzhou, China.

Background: Anesthetic preconditioning (APC) of the myocardium is mediated in part by reversible alteration of mitochondrial function. Nitric oxide (NO) inhibits mitochondrial respiration and may mediate APC-induced cardioprotection. In this study, the effects of isoflurane on different states of mitochondrial respiration during the oxidation of complex I-linked substrates and the role of NO were investigated. Read More

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http://dx.doi.org/10.1159/000485936DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5968286PMC
February 2018
7 Reads

The Role of Dendritic and Endothelial Cells in Cardiorenal Syndrome.

Cardiorenal Med 2018 22;8(2):92-104. Epub 2018 Jan 22.

Baylor Heart and Vascular Institute, Dallas, Texas, USA.

Backgrounds: Dendritic cells (DCs) are antigen-presenting cells that play a central role in innate and adaptive immune responses; however, the cross talk between cardiac and renal DCs in cardiorenal syndrome (CRS) has not yet been fully elucidated. In this setting, endothelial cells (ECs) also contribute to immune responses.

Summary: DC and EC activation and dysfunction have a central role in the pathogenesis of CRS. Read More

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http://dx.doi.org/10.1159/000485937DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5968234PMC
January 2018
5 Reads

Personalized Statin Therapy and Coronary Atherosclerotic Plaque Burden in Asymptomatic Low/Intermediate-Risk Individuals.

Cardiorenal Med 2018 26;8(2):140-150. Epub 2018 Mar 26.

Biomedical and Metabolic Imaging Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA.

Background: Current guidelines for the primary prevention of atherosclerotic cardiovascular disease are based on the estimation of a predicted 10-year cardiovascular disease risk and the average relative risk reduction estimates from statin trials. In the clinical setting, however, decision-making is better informed by the expected benefit for the individual patient, which is typically lacking. Consequently, a personalized statin benefit approach based on absolute risk reduction over 10 years (ARR10 benefit threshold ≥2. Read More

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http://dx.doi.org/10.1159/000487205DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5968283PMC
March 2018
11 Reads

Statins and New-Onset Diabetes in Cardiovascular and Kidney Disease Cohorts: A Meta-Analysis.

Cardiorenal Med 2018 22;8(2):105-112. Epub 2018 Jan 22.

Department of Internal Medicine, State University of New York Downstate Medical Center, Brooklyn, New York, USA.

Background: Statins have long been prescribed for the primary and secondary prevention of cardiovascular disease (CVD) and kidney disease. Their benefits and efficacy are widely accepted in current clinical practice, but like any other therapeutic agents, they have adverse effects. One of the emerging concerns with statin therapy is the development of new-onset diabetes mellitus (NODM), a dreaded risk factor for CVD and kidney disease and widely viewed as CVD equivalent. Read More

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http://dx.doi.org/10.1159/000485196DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5968284PMC
January 2018
8 Reads

lncRNA UCA1 Is a Novel Regulator in Cardiomyocyte Hypertrophy through Targeting the miR-184/HOXA9 Axis.

Cardiorenal Med 2018 20;8(2):130-139. Epub 2018 Mar 20.

Cardiac hypertrophy is closely associated with a series of cardiovascular diseases, including heart failure and sudden death in particular. An in-depth comprehension of the pathogenesis of cardiac hypertrophy will improve the diagnosis and therapy of cardiac hypertrophy. It has been acknowledged that long noncoding RNAs/microRNAs (lncRNAs/miRNAs) are crucial regulators in diverse biological processes, including various cardiovascular diseases, in multiple manners. Read More

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http://dx.doi.org/10.1159/000487204DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5968298PMC
March 2018
10 Reads

Combination Therapy with Renin-Angiotensin System Blockers and Vitamin D Receptor Activators for Predialysis Patients Is Associated with the Incidence of Cardiovascular Events after Dialysis Initiation: A Multicenter Nonrandomized Prospective Cohort Study.

Cardiorenal Med 2017 Dec 3;8(1):71-81. Epub 2017 Nov 3.

Fujita Health University School of Medicine, Toyoake, Japan.

Background: Several human studies reported that the combined use of renin-angiotensin system blockers (RASBs) and vitamin D receptor activators (VDRAs) resulted in decreased urinary protein excretion. However, it is unknown whether this combination therapy influences the incidence of cardiovascular (CV) events in dialysis patients.

Methods: The study was a multicenter nonrandomized prospective cohort analysis including 1,518 patients. Read More

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http://dx.doi.org/10.1159/000479894DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5757592PMC
December 2017
6 Reads

Plasma Volume and Renal Function Predict Six-Month Survival after Hospitalization for Acute Decompensated Heart Failure.

Cardiorenal Med 2017 Dec 3;8(1):61-70. Epub 2017 Nov 3.

Division of Cardiovascular Medicine, University of Virginia Health System, Charlottesville, Virginia, USA.

Background: Plasma volume (PV) is contracted in stable patients with heart failure (HF) due to decongestion strategies. On the other hand, increased PV can adversely affect the trajectory of HF. We therefore examined the effects of increased percentage change in PV (%ΔPV), blood urea nitrogen (BUN), and %ΔPV stratified by BUN and glomerular filtration rate (GFR) on survival after discharge in patients hospitalized for acute decompensated HF (ADHF). Read More

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https://www.karger.com/Article/FullText/481149
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http://dx.doi.org/10.1159/000481149DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5757574PMC
December 2017
13 Reads

Evaluation of the Predictive Value of the Serum Calcium-Magnesium Ratio for All-Cause and Cardiovascular Mortality in Incident Dialysis Patients.

Cardiorenal Med 2017 Dec 11;8(1):50-60. Epub 2017 Oct 11.

Department of Nephrology, Japanese Red Cross Ishinomaki Hospital, Ishinomaki, Japan.

Background/aim: Cardiovascular disease is the most serious cause of death in patients on hemodialysis. Low serum magnesium (Mg) and high serum calcium (Ca) levels have been associated with poor outcome and cardiovascular mortality in patients on maintenance and initiation dialysis. As a more accurate marker is warranted, we evaluated the efficacy of a novel serum Ca-Mg marker of all-cause and cardiovascular mortality that indicates vessel calcification. Read More

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http://dx.doi.org/10.1159/000480739DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5757542PMC
December 2017
7 Reads

Insulin Resistance in Kidney Disease: Is There a Distinct Role Separate from That of Diabetes or Obesity?

Cardiorenal Med 2017 Dec 30;8(1):41-49. Epub 2017 Sep 30.

Research Service, Harry S. Truman Memorial Veterans' Hospital, University of Missouri-Columbia School of Medicine, Columbia, Missouri, USA.

Insulin resistance is a central component of the metabolic dysregulation observed in obesity, which puts one at risk for the development of type 2 diabetes and complications related to diabetes such as chronic kidney disease. Insulin resistance and compensatory hyperinsulinemia place one at risk for other risk factors such as dyslipidemia, hypertension, and proteinuria, e.g. Read More

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http://dx.doi.org/10.1159/000479801DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5757598PMC
December 2017
8 Reads

Elevated Phosphate Levels Trigger Autophagy-Mediated Cellular Apoptosis in H9c2 Cardiomyoblasts.

Cardiorenal Med 2017 Dec 30;8(1):31-40. Epub 2017 Sep 30.

Graduate Institute of Basic Medical Science, China Medical University, Taichung.

Background/aim: In chronic kidney disease (CKD), kidneys fail to maintain phosphorus homeostasis in serum. Elevated phosphorus levels in serum have been associated with cardiovascular diseases in CKD patients and in normal individuals. In this study, we evaluated the level of autophagy- and apoptosis-related markers under different concentrations of hyperphosphate in myocardial cells. Read More

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http://dx.doi.org/10.1159/000479010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5757576PMC
December 2017
7 Reads
1 Citation

Eicosapentaenoic Acid as a Potential Therapeutic Approach to Reduce Cardiovascular Risk in Patients with End-Stage Renal Disease on Hemodialysis: A Review.

Cardiorenal Med 2017 Dec 16;8(1):18-30. Epub 2017 Sep 16.

Scottsdale Cardiovascular Center, PC, Scottsdale, Arizona, USA.

Background: Patients with end-stage renal disease on hemodialysis have excess cardiovascular disease (CVD) burden with substantially increased CV event rates compared with the general population.

Summary: Traditional interventions that, according to standard clinical guidelines, reduce CV risk such as antihypertensive therapy, diet, exercise, and statins are not similarly effective in the hemodialysis population. This raises the question of whether additional risk factors, such as enhanced inflammation and oxidative stress, may drive the increased CVD burden in hemodialysis patients. Read More

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http://dx.doi.org/10.1159/000479391DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5757596PMC
December 2017
9 Reads

Role of Body Mass Index in Acute Kidney Injury Patients after Cardiac Surgery.

Cardiorenal Med 2017 Dec 16;8(1):9-17. Epub 2017 Sep 16.

Department of Nephrology, Zhongshan Hospital, Shanghai Medical College, Fudan University, Shanghai, China.

Background/aims: To explore the association of body mass index (BMI) with the risk of developing acute kidney injury after cardiac surgery (CS-AKI) and for AKI requiring renal replacement therapy (AKI-RRT) after cardiac surgery.

Methods: Clinical data of 8,455 patients undergoing cardiac surgery, including demographic preoperative, intraoperative, and postoperative data were collected. Patients were divided into underweight (BMI <18. Read More

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http://dx.doi.org/10.1159/000477824DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5757531PMC
December 2017
9 Reads

Relevance of Endothelial Cell-Specific Molecule 1 (Endocan) Plasma Levels for Predicting Pulmonary Infection after Cardiac Surgery in Chronic Kidney Disease Patients: The Endolung Pilot Study.

Cardiorenal Med 2017 Dec 31;8(1):1-8. Epub 2017 Aug 31.

Department of Thoracic and Cardiovascular Surgery, EA3920, University Hospital Jean Minjoz, Besançon, France.

Objectives: This pilot study aimed to evaluate the relevance of endocan plasma levels for predicting pulmonary infection after cardiac surgery in patients with chronic kidney disease (CKD).

Methods: Serum collected in a previous prospective cohort study (from 166 patients with preoperative CKD who underwent cardiac surgery) was used. Five patients with postoperative pulmonary infection were compared with 15 randomly selected CKD patients with an uneventful outcome. Read More

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https://www.karger.com/Article/FullText/479337
Publisher Site
http://dx.doi.org/10.1159/000479337DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5757607PMC
December 2017
9 Reads

One-Year Conservative Care Using Sodium Bicarbonate Supplementation Is Associated with a Decrease in Electronegative LDL in Chronic Kidney Disease Patients: A Pilot Study.

Cardiorenal Med 2017 Oct 17;7(4):334-341. Epub 2017 Aug 17.

Division of Nephrology, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro, Brazil.

Background: Chronic kidney disease (CKD) patients develop metabolic acidosis when approaching stages 3 and 4, a period in which accelerated atherogenesis may ensue. Studies in vitro show that low pH may increase low-density lipoprotein (LDL) oxidation, suggesting a role for chronic metabolic acidosis in atherosclerosis. The present study attempted to evaluate the effects of conservative care using oral sodium bicarbonate (NaHCO) supplementation on the electronegative LDL [LDL(-)], a minimally oxidized LDL, plasma levels in CKD patients. Read More

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http://dx.doi.org/10.1159/000478733DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5662953PMC
October 2017
9 Reads

A Profile of Renal Function in Northern Cameroonians with Essential Hypertension.

Cardiorenal Med 2017 Oct 17;7(4):324-333. Epub 2017 Aug 17.

General Medicine Service, Regional Hospital Ngaoundere, University of Ngaoundere, Ngaoundere, Cameroon.

Background/aim: The two-way cause and effect relationship existing between high blood pressure and kidney dysfunction is currently a well-documented phenomenon with patients in either category being almost equally predisposed to the other pathology. Our goal was to assess the renal function capacity of hypertensive patients in our setting.

Methods: This cross-sectional descriptive study involved the determination of blood pressure levels and the collection of blood and urine samples for the measurement of renal function markers. Read More

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https://www.karger.com/Article/FullText/455680
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http://dx.doi.org/10.1159/000455680DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5662973PMC
October 2017
11 Reads

Contrast-Induced Nephropathy Is Less Common in Patients with Good Coronary Collateral Circulation.

Cardiorenal Med 2017 Oct 4;7(4):316-323. Epub 2017 Aug 4.

Cardiology Department, Balikesir University Faculty of Medicine, Balikesir, Turkey.

Background/aims: Contrast-induced nephropathy (CIN) is a typically reversible type of acute renal failure that develops after exposure to contrast agents; underlying endothelial dysfunction is thought to be an important risk factor for CIN. Although the mechanism of coronary collateral circulation (CCC) is not fully understood, a pivotal role of the endothelium has been reported in many studies. The aim of this study was to investigate whether there is a relationship between CCC and CIN. Read More

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http://dx.doi.org/10.1159/000479013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5662979PMC
October 2017
6 Reads