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    247 results match your criteria Cardiorenal medicine[Journal]

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    Metabolic Syndrome and the Iodine-Dose/Creatinine Clearance Ratio as Determinants of Contrast-Induced Acute Kidney Injury.
    Cardiorenal Med 2018 Jun 15;8(3):217-227. Epub 2018 Jun 15.
    Department of Cardiovascular Medicine, Rasoul-e-Akram General Hospital, IUMS, Tehran, Iran.
    Background: Finding patients at risk of developing contrast-induced acute kidney injury (CI-AKI) is important because of its associated complications. In the present study, the contribution of different variables, such as the presence of metabolic syndrome (MetS), the volume creatinine clearance (V/CrCl) ratio, the iodine-dose (I-dose)/CrCl ratio, or hypertension, to CI-AKI was evaluated.

    Methods: A total of 255 patients undergoing elective coronary angiography with or without intervention were enrolled and divided into a MetS and a control group. Read More

    Determinants of Monocyte Apoptosis in Cardiorenal Syndrome Type 1.
    Cardiorenal Med 2018 May 30;8(3):208-216. Epub 2018 May 30.
    Department of Nephrology, Dialysis and Transplant, San Bortolo Hospital, Vicenza, Italy.
    Background: Cardiorenal syndrome type 1 (CRS type 1) is characterized by a rapid worsening of cardiac function leading to acute kidney injury (AKI). Its pathophysiology is complex and not completely understood. In this study, we examined the role of apoptosis and the caspase pathways involved. Read More

    Epicardial Fat Thickness in Patients with Autosomal Dominant Polycystic Kidney Disease.
    Cardiorenal Med 2018 May 3;8(3):199-207. Epub 2018 May 3.
    Unit of Secondary Hypertension, Department of Internal Medicine and Medical Specialties, Sapienza University of Rome, Rome, Italy.
    Introduction: Autosomal dominant polycystic kidney disease (ADPKD) is associated with early organ damage such as left ventricular hypertrophy and higher cardiovascular risk when compared to essential hypertension (EH). Epicardial adipose tissue (EAT) is a new cardiovascular risk factor, but its role and correlation with left ventricular mass (LVM) in ADPKD is unknown.

    Aims: we sought to investigate whether EAT is higher and related to LVM indexed by body surface area (LVMi) in hypertensive patients with ADPKD compared to those with EH. Read More

    ω-3 Polyunsaturated Fatty Acid Postconditioning Protects the Isolated Perfused Rat Heart from Ischemia-Reperfusion Injury.
    Cardiorenal Med 2018 Apr 11;8(3):173-182. Epub 2018 Apr 11.
    Department of Pathology, 421 Hospital of PLA, Guangzhou, China.
    Aims: This study aimed to evaluate the cardioprotective effects of ω-3 polyunsaturated fatty acids (PUFAs) postconditioning against ischemia-reperfusion (I/R) injury.

    Methods: Sixty Sprague-Dawley rats were randomly divided into 4 groups (n = 15 for each) and used to generate the Langendorff isolated perfused rat heart model. The sham group received a continuous perfusion of 150 min. Read More

    Pulmonary Catherization Data Correlate Poorly with Renal Function in Heart Failure.
    Cardiorenal Med 2018 Apr 10;8(3):183-191. Epub 2018 Apr 10.
    School of Public Health, The University of Texas Health Science Center at Houston, Houston, Texas, USA.
    Background: The mechanisms of renal dysfunction in heart failure are poorly understood. We chose to explore the relationship of cardiac filling pressures and cardiac index (CI) in relation to renal dysfunction in advanced heart failure.

    Objectives: To determine the relationship between renal function and cardiac filling pressures using the United Network of Organ Sharing (UNOS) pulmonary artery catherization registry. Read More

    Preeclampsia as a Form of Type 5 Cardiorenal Syndrome: An Underrecognized Entity in Women's Cardiovascular Health.
    Cardiorenal Med 2018 4;8(2):160-172. Epub 2018 Apr 4.
    Baylor University Medical Center, Baylor Heart and Vascular Institute, Dallas, Texas, USA.
    Background: Preeclampsia is a multisystem vascular disorder of pregnancy that remains a leading cause of maternal and fetal morbidity and mortality. Preeclampsia remains an underrecognized risk factor for future cardiovascular and kidney disease in women and represents the confluence of preexisting vascular risk factors with superimposed endothelial injury from placental mediated anti-angiogenic factors.

    Summary: This review highlights the close relationship between preeclampsia and future cardiovascular and kidney disease. Read More

    Relevance of B-Lines on Lung Ultrasound in Volume Overload and Pulmonary Congestion: Clinical Correlations and Outcomes in Patients on Hemodialysis.
    Cardiorenal Med 2018 29;8(2):83-91. Epub 2017 Nov 29.
    Background: Volume overload in patients on hemodialysis (HD) is an independent risk factor for cardiovascular mortality. B-lines detected on lung ultrasound (BLUS) assess extravascular lung water. This raises interest in its utility for assessing volume status and cardiovascular outcomes. Read More

    High Right Ventricular Stroke Work Index Is Associated with Worse Kidney Function in Patients with Heart Failure with Preserved Ejection Fraction.
    Cardiorenal Med 2018 28;8(2):123-129. Epub 2018 Feb 28.
    Cardiology Division, Department of Internal Medicine, Einstein Medical Center, Philadelphia, Pennsylvania, USA.
    Background: In patients with heart failure with preserved ejection fraction (HFpEF), worse kidney function is associated with worse overall cardiac mechanics. Right ventricular stroke work index (RVSWI) is a parameter of right ventricular function. The aim of our study was to determine the relationship between RVSWI and glomerular filtration rate (GFR) in patients with HFpEF. Read More

    Impact of Chronic Kidney Disease on Cardiovascular and Renal Events in Patients Undergoing Percutaneous Coronary Intervention with Everolimus-Eluting Stent: Risk Stratification with C-Reactive Protein.
    Cardiorenal Med 2018 27;8(2):151-159. Epub 2018 Mar 27.
    Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan.
    Background: Chronic kidney disease (CKD) and inflammation play critical roles in atherosclerosis. There is limited evidence regarding the relationship between CKD and patients receiving second-generation drug-eluting stents for coronary artery disease.

    Objective: This study aimed to investigate the effect of CKD on cardiovascular and renal events in patients undergoing percutaneous coronary intervention (PCI) with everolimus-eluting stents (EES). Read More

    The Effect of Mitochondrial Complex I-Linked Respiration by Isoflurane Is Independent of Mitochondrial Nitric Oxide Production.
    Cardiorenal Med 2018 1;8(2):113-122. Epub 2018 Feb 1.
    Institute of Clinical Medicine Research, Suzhou Hospital (West District) Affiliated to Nanjing Medical University, Suzhou Science and Technology Town Hospital, Suzhou, China.
    Background: Anesthetic preconditioning (APC) of the myocardium is mediated in part by reversible alteration of mitochondrial function. Nitric oxide (NO) inhibits mitochondrial respiration and may mediate APC-induced cardioprotection. In this study, the effects of isoflurane on different states of mitochondrial respiration during the oxidation of complex I-linked substrates and the role of NO were investigated. Read More

    The Role of Dendritic and Endothelial Cells in Cardiorenal Syndrome.
    Cardiorenal Med 2018 22;8(2):92-104. Epub 2018 Jan 22.
    Baylor Heart and Vascular Institute, Dallas, Texas, USA.
    Backgrounds: Dendritic cells (DCs) are antigen-presenting cells that play a central role in innate and adaptive immune responses; however, the cross talk between cardiac and renal DCs in cardiorenal syndrome (CRS) has not yet been fully elucidated. In this setting, endothelial cells (ECs) also contribute to immune responses.

    Summary: DC and EC activation and dysfunction have a central role in the pathogenesis of CRS. Read More

    Personalized Statin Therapy and Coronary Atherosclerotic Plaque Burden in Asymptomatic Low/Intermediate-Risk Individuals.
    Cardiorenal Med 2018 26;8(2):140-150. Epub 2018 Mar 26.
    Biomedical and Metabolic Imaging Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA.
    Background: Current guidelines for the primary prevention of atherosclerotic cardiovascular disease are based on the estimation of a predicted 10-year cardiovascular disease risk and the average relative risk reduction estimates from statin trials. In the clinical setting, however, decision-making is better informed by the expected benefit for the individual patient, which is typically lacking. Consequently, a personalized statin benefit approach based on absolute risk reduction over 10 years (ARR10 benefit threshold ≥2. Read More

    Statins and New-Onset Diabetes in Cardiovascular and Kidney Disease Cohorts: A Meta-Analysis.
    Cardiorenal Med 2018 22;8(2):105-112. Epub 2018 Jan 22.
    Department of Internal Medicine, State University of New York Downstate Medical Center, Brooklyn, New York, USA.
    Background: Statins have long been prescribed for the primary and secondary prevention of cardiovascular disease (CVD) and kidney disease. Their benefits and efficacy are widely accepted in current clinical practice, but like any other therapeutic agents, they have adverse effects. One of the emerging concerns with statin therapy is the development of new-onset diabetes mellitus (NODM), a dreaded risk factor for CVD and kidney disease and widely viewed as CVD equivalent. Read More

    lncRNA UCA1 Is a Novel Regulator in Cardiomyocyte Hypertrophy through Targeting the miR-184/HOXA9 Axis.
    Cardiorenal Med 2018 20;8(2):130-139. Epub 2018 Mar 20.
    Cardiac hypertrophy is closely associated with a series of cardiovascular diseases, including heart failure and sudden death in particular. An in-depth comprehension of the pathogenesis of cardiac hypertrophy will improve the diagnosis and therapy of cardiac hypertrophy. It has been acknowledged that long noncoding RNAs/microRNAs (lncRNAs/miRNAs) are crucial regulators in diverse biological processes, including various cardiovascular diseases, in multiple manners. Read More

    Combination Therapy with Renin-Angiotensin System Blockers and Vitamin D Receptor Activators for Predialysis Patients Is Associated with the Incidence of Cardiovascular Events after Dialysis Initiation: A Multicenter Nonrandomized Prospective Cohort Study.
    Cardiorenal Med 2017 Dec 3;8(1):71-81. Epub 2017 Nov 3.
    Fujita Health University School of Medicine, Toyoake, Japan.
    Background: Several human studies reported that the combined use of renin-angiotensin system blockers (RASBs) and vitamin D receptor activators (VDRAs) resulted in decreased urinary protein excretion. However, it is unknown whether this combination therapy influences the incidence of cardiovascular (CV) events in dialysis patients.

    Methods: The study was a multicenter nonrandomized prospective cohort analysis including 1,518 patients. Read More

    Plasma Volume and Renal Function Predict Six-Month Survival after Hospitalization for Acute Decompensated Heart Failure.
    Cardiorenal Med 2017 Dec 3;8(1):61-70. Epub 2017 Nov 3.
    Division of Cardiovascular Medicine, University of Virginia Health System, Charlottesville, Virginia, USA.
    Background: Plasma volume (PV) is contracted in stable patients with heart failure (HF) due to decongestion strategies. On the other hand, increased PV can adversely affect the trajectory of HF. We therefore examined the effects of increased percentage change in PV (%ΔPV), blood urea nitrogen (BUN), and %ΔPV stratified by BUN and glomerular filtration rate (GFR) on survival after discharge in patients hospitalized for acute decompensated HF (ADHF). Read More

    Evaluation of the Predictive Value of the Serum Calcium-Magnesium Ratio for All-Cause and Cardiovascular Mortality in Incident Dialysis Patients.
    Cardiorenal Med 2017 Dec 11;8(1):50-60. Epub 2017 Oct 11.
    Department of Nephrology, Japanese Red Cross Ishinomaki Hospital, Ishinomaki, Japan.
    Background/aim: Cardiovascular disease is the most serious cause of death in patients on hemodialysis. Low serum magnesium (Mg) and high serum calcium (Ca) levels have been associated with poor outcome and cardiovascular mortality in patients on maintenance and initiation dialysis. As a more accurate marker is warranted, we evaluated the efficacy of a novel serum Ca-Mg marker of all-cause and cardiovascular mortality that indicates vessel calcification. Read More

    Insulin Resistance in Kidney Disease: Is There a Distinct Role Separate from That of Diabetes or Obesity?
    Cardiorenal Med 2017 Dec 30;8(1):41-49. Epub 2017 Sep 30.
    Research Service, Harry S. Truman Memorial Veterans' Hospital, University of Missouri-Columbia School of Medicine, Columbia, Missouri, USA.
    Insulin resistance is a central component of the metabolic dysregulation observed in obesity, which puts one at risk for the development of type 2 diabetes and complications related to diabetes such as chronic kidney disease. Insulin resistance and compensatory hyperinsulinemia place one at risk for other risk factors such as dyslipidemia, hypertension, and proteinuria, e.g. Read More

    Elevated Phosphate Levels Trigger Autophagy-Mediated Cellular Apoptosis in H9c2 Cardiomyoblasts.
    Cardiorenal Med 2017 Dec 30;8(1):31-40. Epub 2017 Sep 30.
    Graduate Institute of Basic Medical Science, China Medical University, Taichung.
    Background/aim: In chronic kidney disease (CKD), kidneys fail to maintain phosphorus homeostasis in serum. Elevated phosphorus levels in serum have been associated with cardiovascular diseases in CKD patients and in normal individuals. In this study, we evaluated the level of autophagy- and apoptosis-related markers under different concentrations of hyperphosphate in myocardial cells. Read More

    Eicosapentaenoic Acid as a Potential Therapeutic Approach to Reduce Cardiovascular Risk in Patients with End-Stage Renal Disease on Hemodialysis: A Review.
    Cardiorenal Med 2017 Dec 16;8(1):18-30. Epub 2017 Sep 16.
    Scottsdale Cardiovascular Center, PC, Scottsdale, Arizona, USA.
    Background: Patients with end-stage renal disease on hemodialysis have excess cardiovascular disease (CVD) burden with substantially increased CV event rates compared with the general population.

    Summary: Traditional interventions that, according to standard clinical guidelines, reduce CV risk such as antihypertensive therapy, diet, exercise, and statins are not similarly effective in the hemodialysis population. This raises the question of whether additional risk factors, such as enhanced inflammation and oxidative stress, may drive the increased CVD burden in hemodialysis patients. Read More

    Role of Body Mass Index in Acute Kidney Injury Patients after Cardiac Surgery.
    Cardiorenal Med 2017 Dec 16;8(1):9-17. Epub 2017 Sep 16.
    Department of Nephrology, Zhongshan Hospital, Shanghai Medical College, Fudan University, Shanghai, China.
    Background/aims: To explore the association of body mass index (BMI) with the risk of developing acute kidney injury after cardiac surgery (CS-AKI) and for AKI requiring renal replacement therapy (AKI-RRT) after cardiac surgery.

    Methods: Clinical data of 8,455 patients undergoing cardiac surgery, including demographic preoperative, intraoperative, and postoperative data were collected. Patients were divided into underweight (BMI <18. Read More

    Relevance of Endothelial Cell-Specific Molecule 1 (Endocan) Plasma Levels for Predicting Pulmonary Infection after Cardiac Surgery in Chronic Kidney Disease Patients: The Endolung Pilot Study.
    Cardiorenal Med 2017 Dec 31;8(1):1-8. Epub 2017 Aug 31.
    Department of Thoracic and Cardiovascular Surgery, EA3920, University Hospital Jean Minjoz, Besançon, France.
    Objectives: This pilot study aimed to evaluate the relevance of endocan plasma levels for predicting pulmonary infection after cardiac surgery in patients with chronic kidney disease (CKD).

    Methods: Serum collected in a previous prospective cohort study (from 166 patients with preoperative CKD who underwent cardiac surgery) was used. Five patients with postoperative pulmonary infection were compared with 15 randomly selected CKD patients with an uneventful outcome. Read More

    One-Year Conservative Care Using Sodium Bicarbonate Supplementation Is Associated with a Decrease in Electronegative LDL in Chronic Kidney Disease Patients: A Pilot Study.
    Cardiorenal Med 2017 Oct 17;7(4):334-341. Epub 2017 Aug 17.
    Division of Nephrology, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro, Brazil.
    Background: Chronic kidney disease (CKD) patients develop metabolic acidosis when approaching stages 3 and 4, a period in which accelerated atherogenesis may ensue. Studies in vitro show that low pH may increase low-density lipoprotein (LDL) oxidation, suggesting a role for chronic metabolic acidosis in atherosclerosis. The present study attempted to evaluate the effects of conservative care using oral sodium bicarbonate (NaHCO) supplementation on the electronegative LDL [LDL(-)], a minimally oxidized LDL, plasma levels in CKD patients. Read More

    A Profile of Renal Function in Northern Cameroonians with Essential Hypertension.
    Cardiorenal Med 2017 Oct 17;7(4):324-333. Epub 2017 Aug 17.
    General Medicine Service, Regional Hospital Ngaoundere, University of Ngaoundere, Ngaoundere, Cameroon.
    Background/aim: The two-way cause and effect relationship existing between high blood pressure and kidney dysfunction is currently a well-documented phenomenon with patients in either category being almost equally predisposed to the other pathology. Our goal was to assess the renal function capacity of hypertensive patients in our setting.

    Methods: This cross-sectional descriptive study involved the determination of blood pressure levels and the collection of blood and urine samples for the measurement of renal function markers. Read More

    Contrast-Induced Nephropathy Is Less Common in Patients with Good Coronary Collateral Circulation.
    Cardiorenal Med 2017 Oct 4;7(4):316-323. Epub 2017 Aug 4.
    Cardiology Department, Balikesir University Faculty of Medicine, Balikesir, Turkey.
    Background/aims: Contrast-induced nephropathy (CIN) is a typically reversible type of acute renal failure that develops after exposure to contrast agents; underlying endothelial dysfunction is thought to be an important risk factor for CIN. Although the mechanism of coronary collateral circulation (CCC) is not fully understood, a pivotal role of the endothelium has been reported in many studies. The aim of this study was to investigate whether there is a relationship between CCC and CIN. Read More

    Clinical Usefulness of Urinary Liver Fatty Acid-Binding Protein Excretion for Predicting Acute Kidney Injury during the First 7 Days and the Short-Term Prognosis in Acute Heart Failure Patients with Non-Chronic Kidney Disease.
    Cardiorenal Med 2017 Oct 15;7(4):301-315. Epub 2017 Jul 15.
    Department of Cardiovascular Medicine, Nippon Medical School, Tokyo, Japan.
    Background: The clinical significance of urinary liver fatty acid-binding protein (u-LFABP) in acute heart failure (AHF) patients remains unclear.

    Methods And Results: The u-LFABP levels on admission of 293 AHF patients were analyzed. The patients were divided into 2 groups according to the u-LFABP quartiles (Q1, Q2, and Q3 = low u-LFABP [L] group vs. Read More

    The Relationship between Hypertriglyceridemic Waist Phenotype and Early Diabetic Nephropathy in Type 2 Diabetes.
    Cardiorenal Med 2017 Oct 13;7(4):295-300. Epub 2017 Jul 13.
    Department of Endocrinology, The First Hospital of Qinhuangdao, Qinhuangdao, China.
    Background/aims: The aim of this study was to explore the relationship between hypertriglyceridemic waist (HW) phenotype and early diabetic nephropathy in type 2 diabetes.

    Methods: A cross-sectional study was conducted on 538 type 2 diabetes patients in Qinhuangdao. The HW phenotype was defined as serum triglyceride concentrations ≥1. Read More

    Long-Term Progression of Coronary Artery Calcification Is Independent of Classical Risk Factors, C-Reactive Protein, and Parathyroid Hormone in Renal Transplant Patients.
    Cardiorenal Med 2017 Oct 13;7(4):284-294. Epub 2017 Jul 13.
    Division of Nephrology, Department of Internal Medicine, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey.
    Aims: Compared to the general population, mortality is significantly increased in renal transplant recipients. In the general population, coronary artery calcification (CAC) and its evolution over time are associated with cardiovascular and all-cause mortality, and the study of this biomarker could provide useful information for describing the long-term progression of coronary heart disease in renal transplant recipients.

    Methods: We followed up a cohort of 113 renal transplant patients by performing three multi-detector computed tomography studies over 83. Read More

    The Role of Endotoxin in the Setting of Cardiorenal Syndrome Type 5.
    Cardiorenal Med 2017 Oct 24;7(4):276-283. Epub 2017 Jun 24.
    IRRIV-International Renal Research Institute Vicenza, Vicenza, Italy.
    Lipopolysaccharide or endotoxin, the major cell wall component of gram-negative bacteria, plays a pivotal role in the pathogenesis of sepsis. It is able to activate the host defense system through the interaction with Toll-like receptor 4, thus triggering pro-inflammatory mechanisms. When the production of inflammatory mediators becomes uncontrolled and excessive, septic shock develops with multiple organ dysfunction, such as myocardial and renal impairment, which are hallmarks of cardiorenal syndrome type 5. Read More

    Urinary Liver-Type Fatty Acid-Binding Protein Level as a Predictive Biomarker of Acute Kidney Injury in Patients with Acute Decompensated Heart Failure.
    Cardiorenal Med 2017 Oct 21;7(4):267-275. Epub 2017 Jun 21.
    Cardiovascular Medicine, Tokyo Medical and Dental University, Tokyo, Japan.
    Background: There are no biological markers to predict the onset of acute kidney injury (AKI) in patients with acute decompensated heart failure (ADHF). Liver-type fatty acid-binding protein (L-FABP) levels are markedly upregulated in the proximal tubules after renal ischemia. We investigated whether urinary L-FABP is a suitable marker to predict AKI in ADHF patients. Read More

    Folic Acid and Homocysteine in Chronic Kidney Disease and Cardiovascular Disease Progression: Which Comes First?
    Cardiorenal Med 2017 Oct 21;7(4):255-266. Epub 2017 Jun 21.
    Nephrology, Dialysis, and Transplantation Unit, Department of Experimental, Diagnostic, and Specialty Medicine (DIMES), St. Orsola Hospital, University of Bologna, Bologna, Italy.
    Background: Hyperhomocysteinemia (Hhcy) occurs in about 85% of chronic kidney disease (CKD) patients because of impaired renal metabolism and reduced renal excretion. Folic acid (FA), the synthetic form of vitamin B, is critical in the conversion of homocysteine (Hcy) to methionine. If there is not enough intake of FA, there is not enough conversion, and Hcy levels are raised. Read More

    Urinary Osteopontin Predicts Incident Chronic Kidney Disease, while Plasma Osteopontin Predicts Cardiovascular Death in Elderly Men.
    Cardiorenal Med 2017 Jun 25;7(3):245-254. Epub 2017 May 25.
    School of Health and Social Studies, Dalarna University, Falun, Sweden.
    Background And Objectives: The matricellular protein osteopontin is involved in the pathogenesis of both kidney and cardiovascular disease. However, whether circulating and urinary osteopontin levels are associated with the risk of these diseases is less studied.

    Design Setting Participants And Measurements: A community-based cohort of elderly men (Uppsala Longitudinal Study of Adult Men [ULSAM]; = 741; mean age: 77 years) was used to study the associations between plasma and urinary osteopontin, incident chronic kidney disease, and the risk of cardiovascular death during a median of 8 years of follow-up. Read More

    Characterization of an Animal Model to Study Risk Factors and New Therapies for the Cardiorenal Syndrome, a Major Health Issue in Our Aging Population.
    Cardiorenal Med 2017 Jun 24;7(3):234-244. Epub 2017 May 24.
    Laboratory of Pathophysiology, University of Antwerp, Antwerp, Belgium.
    Background: The cardiorenal syndrome (CRS) is a major health problem in our aging population. The term was introduced to cover disorders of the kidneys and heart, whereby dysfunction of one organ may induce dysfunction of the other. As the natural history of the CRS is mostly slow, hence difficult to explore in clinical trials, adequate animal models combining cardiovascular and renal disease are required. Read More

    Estimated Glomerular Filtration Rate and 6-Minute Walk Distance in African Americans with Mild to Moderate Heart Failure.
    Cardiorenal Med 2017 Jun 24;7(3):227-233. Epub 2017 May 24.
    Department of Biobehavioral Health Science, University of Illinois at Chicago College of Nursing, Chicago, IL, USA.
    Background/aims: The 6-minute walk test is a measure of functional capacity in patients with heart failure (HF) or chronic kidney disease (CKD). The association between estimated glomerular filtration rate (eGFR) and 6-minute walk distance (6MWD) has not been investigated in African-Americans (AA), despite them having a higher incidence of CKD and chronic HF. Thus, our aim was to determine if eGFR was an independent predictor of 6MWD in AA >50 years of age with HF. Read More

    Brain Natriuretic Peptide Is a Marker of Fluid Overload in Incident Hemodialysis Patients.
    Cardiorenal Med 2017 Jun 29;7(3):218-226. Epub 2017 Apr 29.
    NephroCare Tassin-Charcot, Sainte-Foy-lès-Lyon, Nancy, France.
    Background/aims: Brain natriuretic peptide (BNP) is secreted by cardiomyocytes under stretch condition. High blood levels are associated with decreased patient survival in heart failure patients and in hemodialysis (HD) patients. We report the monthly BNP change in the first months of HD therapy in incident patients and its relationship with fluid removal and cardiac history (CH). Read More

    Recent Advances in Stroke Prevention in Patients with Atrial Fibrillation and End-Stage Renal Disease.
    Cardiorenal Med 2017 Jun 27;7(3):207-217. Epub 2017 Apr 27.
    Department of Medicine and Surgery, University of Milan-Bicocca, Milan, Italy.
    Background: Chronic kidney disease (CKD) is associated with a high prevalence of atrial fibrillation (AF), but in this population the risk/benefit ratio of anticoagulant therapy with vitamin K antagonists (VKA) for thromboprophylaxis is uncertain.

    Summary: In end-stage renal disease (ESRD) patients undergoing hemodialysis, VKA seem less effective in stroke prevention than in the general population, with an increased risk of major bleeding. Recently, novel oral anticoagulant agents (NOACs) have proven to be effective for stroke prevention in AF and have demonstrated an improved safety profile compared to VKA. Read More

    Nonparallel Progression of Left Ventricular Structure and Function in Long-Term Peritoneal Dialysis Patients.
    Cardiorenal Med 2017 Jun 22;7(3):198-206. Epub 2017 Apr 22.
    Department of Nephrology, Second Affiliated Hospital of Soochow University, Suzhou, China.
    Background/aims: Left ventricular hypertrophy and dysfunction are key cardiovascular risk factors of patients on peritoneal dialysis (PD). The purpose of this study was to investigate the dynamic changes of left ventricular (LV) structure and function in patients on long-term PD.

    Methods: Patients who underwent PD catheter insertions from January 2010 to December 2012 in our PD center were enrolled into this study. Read More

    Levocarnitine Injections Decrease the Need for Erythropoiesis-Stimulating Agents in Hemodialysis Patients with Renal Anemia.
    Cardiorenal Med 2017 Jun 20;7(3):188-197. Epub 2017 Apr 20.
    Division of Nephrology, Hypertension and Endocrinology, Department of Internal Medicine, Nihon University School of Medicine, Tokyo, Japan.
    Aims: The aim of this study was to evaluate the efficacy of levocarnitine injection for renal anemia in hemodialysis patients.

    Methods: In this randomized controlled clinical trial, we randomly assigned patients on maintenance hemodialysis at our hospital to receive levocarnitine injections ( = 30) or no injection ( = 30) and monitored the patients during 12 months of treatment. In the treatment group, patients received an injection of levocarnitine 1,000 mg 3 times weekly after hemodialysis sessions. Read More

    Evaluation of the CRUSADE Risk Score for Predicting Major Bleeding in Patients with Concomitant Kidney Dysfunction and Acute Coronary Syndromes.
    Cardiorenal Med 2017 Jun 17;7(3):179-187. Epub 2017 Feb 17.
    Division of Cardiology, University Hospital Virgen de la Arrixaca, School of Medicine, Murcia, Spain.
    Background: Kidney dysfunction (KD) has been associated with increased risk for major bleeding (MB) in patients with acute coronary syndromes (ACS) and may be in part related to an underuse of evidence-based therapies. Our aim was to assess the predictive ability of the Can Rapid risk stratification of Unstable angina patients Suppress ADverse outcomes with Early implementation of the ACC/AHA guidelines (CRUSADE) risk score in patients with concomitant ACS and chronic kidney disease.

    Methods: We conducted a retrospective analysis of a prospective registry including 1,587 ACS patients. Read More

    The Effect of Admission Renal Function on the Treatment and Outcome of Patients with Acute Coronary Syndrome.
    Cardiorenal Med 2017 Jun 17;7(3):169-178. Epub 2017 Feb 17.
    Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
    Background: Chronic kidney disease is a frequent comorbidity among patients with acute coronary syndrome (ACS). We aimed to evaluate treatment characteristics in ACS patients according to their renal function and to assess the effect of differences in therapy on clinical outcomes.

    Methods: Included were patients with ACS enrolled in the biennial Acute Coronary Syndrome Israeli Surveys (ACSIS) during 2000-2013. Read More

    Association of Growth Differentiation Factor 15 with Mortality in a Prospective Hemodialysis Cohort.
    Cardiorenal Med 2017 Feb 2;7(2):158-168. Epub 2017 Feb 2.
    Harold Simmons Center for Kidney Disease Research and Epidemiology, University of California Irvine, Orange, CA, USA.
    Background/aims: Cardiovascular disease and protein-energy wasting are among the strongest predictors of the high mortality of dialysis patients. In the general population, the novel cardiovascular and wasting biomarker, growth differentiation factor 15 (GDF15), is associated with decreased survival. However, little is known about GDF15 in dialysis patients. Read More

    Prognostic Implications of Chronic Kidney Disease on Patients Presenting with ST-Segment Elevation Myocardial Infarction with versus without Stent Thrombosis.
    Cardiorenal Med 2017 Feb 28;7(2):150-157. Epub 2017 Jan 28.
    Department of Cardiology, Tel Aviv Sourasky Medical Center Affiliated to the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
    Background: Limited data is present regarding long-term outcomes in chronic kidney disease (CKD) patients presenting with stent thrombosis (ST). We evaluated the possible implications of CKD on long-term mortality in patients presenting with ST-segment elevation myocardial infarction (STEMI) and treated with primary percutaneous coronary intervention (PCI), and its interaction with the presence of ST.

    Methods: We retrospectively studied 1,722 STEMI patients treated with primary PCI. Read More

    Lack of Diuretic Efficiency (but Not Low Diuresis) Early in An Acutely Decompensated Heart Failure Episode Is Associated with Increased 180-Day Mortality.
    Cardiorenal Med 2017 Feb 21;7(2):137-149. Epub 2017 Jan 21.
    Intensive Care Unit, Centro Hospitalar do Porto, Porto, Portugal.
    Introduction: The assessment of the amount of urine produced by the dose of administered diuretic has been proposed as the main signal of interest in diuretic responsiveness - diuretic efficiency (DE). The main aim of our study is to determine if a low DE is associated with 180-day all-cause mortality (ACM).

    Methods: During a 3-year period, we retrospectively studied patients with acutely decompensated heart failure (ADHF) and respiratory insufficiency admitted to the emergency room of a tertiary university hospital in Porto, Portugal. Read More

    Spironolactone Treatment and Effect on Survival in Chronic Heart Failure Patients with Reduced Renal Function: A Propensity-Matched Study.
    Cardiorenal Med 2017 Feb 20;7(2):128-136. Epub 2017 Jan 20.
    Department of Nephrology, Oslo University Hospital, Ullevål, Oslo, Norway.
    Background/aims: Spironolactone may be hazardous in heart failure (HF) patients with renal dysfunction due to risk of hyperkalemia and worsened renal function. We aimed to evaluate the effect of spironolactone on all-cause mortality in HF outpatients with renal dysfunction in a propensity-score-matched study.

    Methods: A total of 2,077 patients from the Norwegian Heart Failure Registry with renal dysfunction (eGFR <60 mL/min/1. Read More

    Initiation and Cessation Timing of Renal Replacement Therapy in Patients with Type 1 Cardiorenal Syndrome: An Observational Study.
    Cardiorenal Med 2017 Feb 20;7(2):118-127. Epub 2017 Jan 20.
    Department of Nephrology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
    Background/aims: Renal replacement therapy (RRT) is a rescue therapy for patients with type 1 cardiorenal syndrome (CRS) with poor prognoses. However, the optimal timing for initiation and cessation of RRT remains controversial. The purpose of this study was to determine the optimal timing of initiation and cessation of RRT for patients with type 1 CRS. Read More

    The Central Role of Endothelial Dysfunction in Cardiorenal Syndrome.
    Cardiorenal Med 2017 Feb 29;7(2):104-117. Epub 2016 Dec 29.
    Baylor Heart and Vascular Institute, TX, USA.
    Background: Endothelial dysfunction (ED) has emerged as a critical process in cardiorenal syndrome (CRS). The concept that ED is closely linked with cardiac and renal dysfunction has become an important target for CRS-related research and clinical practice.

    Summary: The sequence of events leading to ED is initiated by type I endothelial activation (almost immediately) and type II endothelial activation (over hours, days, and even months), followed by endothelial apoptosis and endothelial necrosis. Read More

    Apolipoprotein L1 Genetic Variants Are Associated with Chronic Kidney Disease but Not with Cardiovascular Disease in a Population Referred for Cardiac Catheterization.
    Cardiorenal Med 2017 Feb 29;7(2):96-103. Epub 2016 Dec 29.
    Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC, USA.
    Background: While the association between genetic variants and chronic kidney disease (CKD) has been established, their association with cardiovascular disease (CVD) is unclear. This study sought to understand CKD and cardiovascular risk conferred by variants in a secondary cardiovascular prevention population.

    Methods: Two risk variants in were genotyped in African-Americans ( = 1,641) enrolled in the CATHGEN biorepository, comprised of patients referred for cardiac catheterization at Duke University Hospital, Durham, NC, USA (2001-2010). Read More

    Long-Term Percutaneous Coronary Intervention Outcomes of Patients with Chronic Kidney Disease in the Era of Second-Generation Drug-Eluting Stents.
    Cardiorenal Med 2017 Feb 9;7(2):85-95. Epub 2016 Dec 9.
    Third Division of Cardiology, Medical University of Silesia, Katowice, Poland.
    Background: The following registry (Katowice-Zabrze retrospective registry) aimed to assess the influence of a chronic kidney disease (CKD) on long-term clinical outcomes in patients undergoing percutaneous coronary intervention (PCI) using either first-generation (DES-I) or second-generation (DES-II) drug-eluting stents.

    Methods: The study group consisted of 1,908 consecutive patients, of whom 331 (17.3%) had CKD. Read More

    The Triad of Sleep Apnea, Hypertension, and Chronic Kidney Disease: A Spectrum of Common Pathology.
    Cardiorenal Med 2016 Nov 5;7(1):74-82. Epub 2016 Nov 5.
    Division of Nephrology, University of Missouri Health Science Center, Columbia, MO, USA; Nephrology Section, Harry S. Truman Veterans' Hospital, Columbia, MO, USA.
    Obstructive sleep apnea (OSA), hypertension, and chronic kidney disease (CKD) are different entities and are generally managed individually most of the time. However, CKD, OSA, and hypertension share many common risk factors and it is not uncommon to see this complex triad together. In fact, they share similar pathophysiology and have been interlinked with each other. Read More

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