117,312 results match your criteria Cardiomyopathy Takotsubo
Eur J Radiol 2018 Dec 21;109:235-247. Epub 2018 Oct 21.
Division of General Radiology, Department of Radiology, Medical University of Graz, Auenbruggerplatz 19/P, 8036 Graz, Austria; Research & Development, Siemens Healthcare Diagnostics GmbH, Strassgangerstrasse 315, 8054 Graz, Austria. Electronic address:
Non-invasive identification and differentiation of myocardial diseases represents the primary objectives of cardiac magnetic resonance (CMR) longitudinal relaxation time (T1) and extracellular volume (ECV) mapping. Given the fact that myocardial T1 and ECV values overlap throughout and within left ventricular phenotypes, a central issue to be addressed is whether and to what extent myocardial T1 and ECV mapping provides additional or superior diagnostic information to standard CMR imaging, and whether native T1 mapping could be employed as a non-contrast alternative to late gadolinium enhancement (LE) imaging. The present review aims to summarize physiological and pathophysiological alterations in native T1 and ECV values and summarized myocardial T1 and ECV alterations associated with cardiac diseases to support the translation of research findings into routine CMR imaging. Read More
West J Nurs Res 2018 Dec 12:193945918817039. Epub 2018 Dec 12.
2 The University of Iowa, Iowa City, IA, USA.
The purpose of this study was to identify characteristics of family relationships associated with communication of genetic risk and testing behaviors among at-risk relatives in families with an inherited cardiac condition. Data were collected from 53 patients and parents of children with an inherited cardiac condition through interviews, pedigrees, and surveys. Associations were examined among family relationship characteristics and whether at-risk relatives were informed about their risk and tested for disease. Read More
Methods Mol Biol 2019 ;1901:95-102
Berlin Cures GmbH, Berlin, Germany.
Agonistically acting autoantibodies directed against the adrenergic beta-1 receptor (beta1-AABs) are a pathogenic factor in diseases of the heart and circulatory system such as dilated cardiomyopathy. Here we describe the detection of such functionally active beta1-AABs from serum samples using spontaneously beating neonatal rat cardiomyocytes, which express the fully functional adrenergic beta-1 receptor coupled with the signal transduction pathway that induces chronotropy. With serum samples added (containing beta1-AABs), an increased positive chronotropic effect is caused that can be blocked by the subsequent addition of specific beta-blockers (abolishing this chronotropic response). Read More
Am J Cardiol 2018 Nov 24. Epub 2018 Nov 24.
Department of Cardiology, Atlanta VA Medical Center, Decatur, Georgia; Department of Cardiology, Emory University School of Medicine, Atlanta, Georgia. Electronic address:
Takotsubo cardiomyopathy (TC) develops in patients who are under significant emotional, psychosocial, or sudden biochemical stress. However, the added burden of TC on the patients receiving chemotherapy has never been studied. We aimed to describe the additional clinical and economic burden, along with the potential predictors of TC and related in-hospital mortality in patients receiving chemotherapy using the largest inpatient cohort. Read More
J Cardiol Cases 2014 Jun 18;9(6):233-235. Epub 2014 Apr 18.
Cardiovascular Division, Department of Medicine II, Kansai Medical University, Osaka, Japan.
A patient without any known congenital cardiac abnormalities who suffered from ventricular tachycardia was taken to the emergency room following successful resuscitation. Transthoracic echocardiography showed diffuse left ventricle dysfunction and mild aortic regurgitation. Coronary angiography demonstrated intact coronary and suspected morphological abnormalities of the aortic valve. Read More
J Cardiol Cases 2014 Jun 6;9(6):221-225. Epub 2014 Mar 6.
Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Hyogo, Japan.
We report the definite long-term natural history of a man with apical hypertrophic cardiomyopathy (ApHCM), who developed an apical aneurysm by the age of 60 years. At 33 years, his electrocardiogram (ECG) was nearly normal. T-wave inversions were first identified in leads V5-6 of an ECG at 36 years of age. Read More
J Cardiol Cases 2014 May 11;9(5):179-182. Epub 2014 Feb 11.
Cardiovascular Division, Department of Internal Medicine, Hyogo College of Medicine, Hyogo, Japan.
Hyponatremia often associates with heart failure. Although severe salt restriction is generally recommended in heart failure treatment, it may promote hyponatremia which is a risk factor for increased morbidity and mortality in heart failure patients. Therefore, it is not yet clear whether correction of hyponatremia is an effective treatment in congestive heart failure with hyponatremia. Read More
J Cardiol Cases 2014 Mar 7;9(3):117-120. Epub 2014 Jan 7.
Division of Cardiovascular Medicine, Koseiren Tsurumi Hospital, Beppu, Japan.
We herein report the case of a 72-year-old female with a lateral wall acute myocardial infarction (MI) complicated by takotsubo cardiomyopathy (TC). The patient presented with "severe" chest pain lasting for one hour. She did not experience any obvious emotional or physical stress preceding the chest pain. Read More
J Cardiol Cases 2014 Feb 13;9(2):71-74. Epub 2013 Dec 13.
Department of Neurosurgery, Shizuoka City Shizuoka Hospital, Shizuoka, Japan.
A 37-year-old female who delivered her second child via a cesarean section 4 months previously presented to our hospital with gradual worsening of dyspnea on effort. Chest radiographic appearance showed cardiomegaly (cardiothoracic ratio 61%) and slight bilateral pulmonary congestion. Echocardiogram revealed diffuse hypokinesis of both left and right ventricles (left ventricular ejection fraction 29%) and large biventricular thrombus [left ventricular apex (28 mm × 21 mm, 22 mm × 14 mm) and right ventricular apex (16 mm × 11 mm)]. Read More
J Cardiol Cases 2014 Feb 13;9(2):50-53. Epub 2013 Dec 13.
Department of Disease Control and Homeostasis, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan.
Functional mitral regurgitation (MR) is a common complication accompanying left ventricular dysfunction. Increasing resting heart rate (HR) is demonstrated to be associated with increased mortality in heart failure (HF) patients. Thus, lowering HR is recommended by recent HF management guidelines. Read More
J Cardiol Cases 2013 Dec 29;8(6):183-186. Epub 2013 Oct 29.
Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai 980-8574, Japan.
A 47-year-old Japanese woman was transported to our hospital due to acute heart failure (AHF). She had been diagnosed with primary hyperparathyroidism (pHPT) and undergone parathyroidectomy 3 months previously. Chest X-ray showed marked cardiomegaly and severe pulmonary congestion, and transthoracic echocardiography indicated both left ventricular (LV) systolic and diastolic dysfunction, complicated with extensive massive myocardial calcification and no LV hypertrophy. Read More
J Cardiol Cases 2015 Jul 2;12(1):26-29. Epub 2015 May 2.
Division of Cardiology, Department of Medicine, Nihon University School of Medicine, Tokyo, Japan.
We present two cases in which takotsubo cardiomyopathy (TC) developed immediately after a diagnosis of microvascular angina had been established. One patient who had been diagnosed as having endothelium-dependent microvascular angina (microvascular spasm) developed TC three weeks after the initial admission. The other patient was diagnosed as having endothelium-independent microvascular angina (decreased coronary flow reserve) and subsequently developed TC after the discontinuation of nicorandil treatment. Read More
J Cardiol Cases 2015 Jul 1;12(1):16-19. Epub 2015 May 1.
Department of Cardiology, Takeda General Hospital, Kyoto, Japan.
Heat stroke is a severe illness characterized by a core temperature >40 °C (104 °F) and central nervous system abnormalities, such as delirium, convulsions, or coma, resulting from exposure to environmental heat or strenuous physical experience. We describe a case with high body temperature and coma, who also presented with wide QRS tachycardia and shock. He was initially treated for heat stroke and wide QRS tachycardia. Read More
J Cardiol Cases 2015 Feb 25;11(2):69-72. Epub 2014 Nov 25.
Division of Cardiovascular Medicine, Kanazawa University Graduate School of Medicine, Kanazawa, Japan.
A 65-year-old man with a history of hypertension was admitted to our hospital with fainting and syncope. He had experienced recurrent syncope since 20 years of age. On admission, systolic heart murmur was audible at the apex of the heart. Read More
J Cardiol Cases 2014 Dec 6;10(6):231-234. Epub 2014 Sep 6.
Department of Internal Medicine Section on Cardiology at the Wake Forest University School of Medicine, Winston-Salem, NC, USA.
This is a case of a 48-year-old man who presented with a pulmonary embolism and was found to have left ventricular non-compaction cardiomyopathy. Initial echocardiograms demonstrated prominent apical trabeculations with reduced biventricular function. These findings were further confirmed and characterized by cardiac magnetic resonance imaging. Read More
J Cardiol Cases 2014 Dec 26;10(6):216-220. Epub 2014 Sep 26.
The Division of Cardiology, Okinawa Chubu Hospital, Okinawa, Japan.
Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a multigenic form of cardiomyopathy characterized by myocardial loss and fibrofatty replacement mainly in the right ventricle. Progressive right ventricular dysfunction, ventricular arrhythmias, and sudden cardiac death are the clinical picture of this disease. Despite its clinical importance as a cause of sudden death, ARVC is likely to be under-recognized. Read More
J Cardiol Cases 2014 Dec 29;10(6):208-212. Epub 2014 Aug 29.
Department of Cardiovascular Medicine, Tokyo Medical and Dental University, Tokyo, Japan.
An association of atrial arrhythmias with takotsubo cardiomyopathy (TTC) has not been described previously. Here we report a 65-year-old male patient with TTC. The sudden appearance of atrioventricular block and subsequent bradycardia are believed to be key contributing factors for the development of TTC. Read More
J Cardiol Cases 2014 Nov 10;10(5):180-183. Epub 2014 Aug 10.
Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan.
Dilated cardiomyopathy is a delayed-onset and rarely reported cardiac complication of burn injury although the mechanism remains unclear. We thus report a case of dilated cardiomyopathy following severe burn injury, in which technetium 99m sestamibi single-photon emission computed tomography (SPECT), iodine-123 beta-methyl-iodophenylpentadecanoic acid SPECT and F-fluorodeoxyglucose positron emission tomography (PET) were performed to evaluate the pathophysiologic condition in combination with cardiac catheterization and myocardial biopsy. The cardiac PET and SPECT images showed reduced myocardial blood flow, decreased fatty acid metabolism, and increased glucose utilization in the left ventricular lateral wall in spite of normal coronary angiography, no significant cardiac fibrosis, and inflammatory cell infiltration, which suggests that myocardial ischemia due to microcirculatory disturbance in hypermetabolic state associated with burn injury might be a causative mechanism of dilated cardiomyopathy in this case. Read More
J Cardiol Cases 2014 Nov 26;10(5):167-170. Epub 2014 Aug 26.
Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto City, Japan.
A 34-year-old man presented with heart failure (HF). He suffered opportunistic infections and was shown to be human immunodeficiency virus (HIV)-positive (viral load: 156,013 copies/mL) and have low CD4 lymphocytes (3/mm), so he was initially treated for the opportunistic infections. Initial investigations showed high elevation of brain natriuretic peptide (BNP: 969 pg/mL). Read More
J Cardiol Cases 2014 Oct 6;10(4):136-139. Epub 2014 Aug 6.
Department of Cardiovascular Medicine, Osaka Graduate School of Medicine, Suita, Japan.
A 60-year-old woman with dilated cardiomyopathy was referred to our hospital due to recurrent syncope. The electrocardiogram recorded by an implantable loop recorder during a syncopal episode revealed an episode of ventricular fibrillation lasting almost 3 min that terminated spontaneously. A detailed analysis of the rhythm strip showed that the chaotic rhythm became an organized ventricular rhythm with a cycle length of 220 ms for the last 14 s before it terminated. Read More
J Cardiol Cases 2014 Oct 17;10(4):129-131. Epub 2014 Jul 17.
Division of Cardiology, Schuechtermann Clinic, Bad Rothenfelde, Germany.
We describe a case of Takotsubo cardiomyopathy in a 75-year-old woman after an elective extraction of 10 teeth of the lower jaw using bilateral mandibular anesthesia. The patient complained of shortness of breath and chest pain after 24 h. Coronary angiography showed smooth normal coronary arteries with thrombolysis in myocardial infarction III flow. Read More
J Cardiol Cases 2014 Jul 10;10(1):19-21. Epub 2014 May 10.
Department of Cardiology, Seth GSMC& KEMH, Mumbai, India.
A 26 year primigravida, 8 days after delivering a still born baby presented with gradually progressive dyspnea from New York Heart Association (NYHA) class II to class III over a period of 1 week. 2D-Echocardiography showed severely compromised left ventricular systolic function with evidence of thrombi in three different chambers of the heart. All the clots disappeared after an effective anticoagulation therapy without any embolic complications. Read More
J Cardiol Cases 2013 May 15;7(5):e133-e136. Epub 2013 Feb 15.
Department of Cardiology and Hematology, Fukushima Medical University, 1 Hikarigaoka, Fukushima 960-1295, Japan.
A 72-year-old woman was admitted to a local hospital due to repeated chest pain in December 2011. On admission, blood tests showed elevation of cardiac enzyme and B-type natriuretic peptide levels. Electrocardiography showed ST-segment elevation in almost all leads. Read More
J Cardiol Cases 2013 Apr 6;7(4):e109-e113. Epub 2013 Feb 6.
Division of Cardiology, National Center for Global Health and Medicine, 1-21-1 Toyama, Shinjuku-ku, Tokyo 162-8655, Japan.
An 86-year-old woman was admitted to hospital with a head injury secondary to an episode of syncope associated with incontinence. Electrocardiography showed complete atrioventricular block, giant negative T waves in the precordial leads, and QT interval prolongation. Emergency coronary angiography showed no significant coronary stenosis, while left ventriculography demonstrated midventricular ballooning. Read More
J Cardiol Cases 2013 Apr 17;7(4):e104-e108. Epub 2013 Jan 17.
Division of Cardiology, Department of Internal Medicine, Tungs' Taichung MetroHarbor Hospital, No. 699, Sec. 1, Chungchi Rd., Wuchi, Taichung 43503, Taiwan.
Stress cardiomyopathy (SCM) is a syndrome of transient cardiac abnormalities precipitated by intense emotional or physical stress. Differentiating SCM from acute myocardial infarction is often difficult but vital to avoid subjecting SCM patients to unnecessary reperfusion therapy and invasive coronary angiography. For accurate diagnosis, it is important that physicians be familiar with the current diagnostic criteria, most susceptible populations, and typical triggers for SCM. Read More
J Cardiol Cases 2013 Mar 3;7(3):e68-e70. Epub 2012 Dec 3.
Le2i UMR CNRS 5158, Dijon, France.
We report the case of a 21-year-old man admitted to the intensive-care unit after resuscitation from a sudden cardiac death (SCD) while he was playing football. Using a wide range of imaging techniques, we diagnosed a singular association between a hypertrophic cardiomyopathy (HCM) and an abnormal left coronary artery origin from the right coronary artery. Coronary artery anomalies, after HCM, are the second most common cause of SCD during exercise in young athletes, but the association between these 2 diseases is very uncommon. Read More
J Cardiol Cases 2013 Feb 4;7(2):e37-e41. Epub 2012 Dec 4.
Department of Myocardial Dysfunction and Heart Failure, B.V. Petrovsky Russian Research Centre of Surgery RAMS, 119991, Abrikosovky per, 6, Moscow, Russia.
LEOPARD syndrome is a phenotypic expression of mutations in several genes: PTPN11, RAF1, and BRAF. All these genes are responsible for Ras/MARK signaling pathway, which are important for cell cycle regulation, differentiation, growth, and aging. Mutations result in anomalies of skin, skeletal, and cardiovascular systems. Read More
J Cardiol Cases 2013 Jan 11;7(1):e27-e28. Epub 2012 Dec 11.
Division of Cardiology, Department of Medicine II, Kansai Medical University, 2-3-1 Shinmachi, Hirakata, Osaka 573-1191, Japan.
J Cardiol Cases 2013 Jan 19;7(1):e1-e3. Epub 2012 Aug 19.
Department of Cardiology, Yokohama Rosai Hospital, 3211 Kozukue-cho, Kohoku-ku, Yokohama 222-0036, Japan.
A 65-year-old woman, with valvular heart disease, atrial fibrillation, and depression, presented to the emergency room due to dyspnea with shock state accompanied by agitation. An electrocardiogram showed ST segment elevation in leads II, III, aV, I, aV, and V. An echocardiography revealed extensive akinesis in the apex, but hyperkinesis in the base, with apical ballooning appearance. Read More
J Cardiol Cases 2012 Dec 6;6(6):e166-e169. Epub 2012 Jul 6.
Division of Cardiovascular Medicine, Kanazawa University Graduate School of Medicine, Kanazawa, Japan.
We report the case of a 74-year-old woman who presented with recurrent episodes of polymorphic ventricular tachycardia (PVT) with a normal QT interval due to digitalis intoxication (serum digoxin concentration, 5.0 ng/mL) and severe hyperkalemia (serum potassium level, 8.3 mEq/L). Read More
J Cardiol Cases 2012 Oct 6;6(4):e112-e115. Epub 2012 Jul 6.
Sanford Hospital, University of South Dakota Medical Center, 1305 West 18th Street, Sioux Falls, SD 57117, USA.
Takotsubo cardiomyopathy is characterized by transient systolic ballooning of apical or mid segments of the left ventricle (LV) mimicking acute myocardial infarction in the absence of obstructive epicardial coronary artery disease. Recurrences remain rare and most recurrence case reports are about apical ballooning or typical Takotsubo cardiomyopathy. We present a rare case of recurrence in mid ventricular ballooning or atypical variant of Takotsubo cardiomyopathy. Read More
J Cardiol Cases 2012 Sep 6;6(3):e70-e74. Epub 2012 Jun 6.
Cardiovascular Division, Department of Medicine II, Kansai Medical University, Hirakata, Osaka, Japan.
Although some atypical types of transient left ventricular apical ballooning syndrome have been reported, only a few atypical types of transient mid-ventricular ballooning have been reported. A 70-year-old female underwent surgery for urothelial carcinoma. At day 5 after the surgery, she was admitted to our department without cardiac symptoms because of ST elevation in leads I, II, III, aVF and V1-V6 indicating acute coronary syndrome. Read More
J Cardiol Cases 2012 Jun 19;5(3):e155-e159. Epub 2012 Apr 19.
Cooper Clinic, Dallas, TX, USA.
An 83-year-old Caucasian female was referred for dobutamine stress echocardiography. At peak dobutamine stress, no chest pain was elicited, and there were no ischemic electrocardiographic changes or inducible wall motion abnormalities. During recovery, however, the patient experienced chest burning, and ST-elevations were seen on recovery electrocardiography. Read More
J Cardiol Cases 2012 Apr 16;5(2):e100-e106. Epub 2012 Mar 16.
Department of Cardiology, Saga Prefectural Hospital Koseikan, 1-12-9 Mizugae, Saga, Japan.
This report presents the case of a 54-year-old female with Takotsubo cardiomyopathy that recurred 12 years after the first episode. The coronary angiography at the first admission revealed ergonovine-induced coronary vasoconstriction in the left coronary artery, and recurrence recurred after the interruption of vasodilator therapy to prevent vasospasm. In addition, the coronary angiography both in the first and second event demonstrated coronary slow flow phenomenon, which improved after the intracoronary administration of nicorandil. Read More
J Cardiol Cases 2012 Feb 27;5(1):e65-e68. Epub 2011 Nov 27.
Department of Cardiovascular Medicine, Kumamoto University School of Medicine, Kumamoto, Japan.
Two male patients, one in his thirties and the other in his fifties, were admitted to different hospitals for congestive heart failure (CHF). In both patients, laboratory findings indicated high plasma B-type natriuretic peptide (BNP) levels (266.0 and 902. Read More
J Cardiol Cases 2011 Dec 20;4(3):e138-e142. Epub 2011 Aug 20.
Department of Pathology, Kitakyushu Municipal Medical Center, Kitakyushu, Japan.
A 49-year-old woman was referred to our hospital for uncontrollable heart failure. She had never been diagnosed as having sarcoidosis. Chest X-ray showed cardiomegaly without bilateral hilar lymphadenopathy. Read More
J Cardiol Cases 2011 Oct 11;4(2):e110-e114. Epub 2011 Aug 11.
Division of Cardiology, Hokkaido Chuo Rosai Hospital, Iwamizawa, Hokkaido, Japan.
A 42-year-old man with a more than 10-year history of hypertrophic obstructive cardiomyopathy, but no history of heart failure or syncope, had left ventricular outflow tract pressure gradient (LVOT-PG) of 50-80 mmHg on Doppler echocardiography. In June 2010, he experienced general malaise on effort, and LVOT-PG increased to 124 mmHg. Two months later, he suffered a transient ischemic attack, complicated with atrial fibrillation (AF). Read More
J Cardiol Cases 2011 Oct 9;4(2):e71-e75. Epub 2011 Aug 9.
Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto City, Japan.
Tako-tsubo cardiomyopathy is characterized by transient left ventricular contractile dysfunction. The precise etiology of tako-tsubo cardiomyopathy remains to be elucidated. We performed coronary angiography in two patients with tako-tsubo cardiomyopathy and evaluated the coronary microcirculation by digital subtraction angiography (DSA). Read More
J Cardiol Cases 2011 Jun 27;3(3):e154-e158. Epub 2011 Mar 27.
Department of Medicine, Division of Cardiology, Jacobi Medical Center, Bronx, NY, USA.
Left apical ballooning syndrome, also known as Takotsubo cardiomyopathy (TTC), characterized by transient left ventricular dysfunction is increasingly recognized worldwide. Predominantly affecting females, this condition mimics myocardial infarction and often occurs in the setting of emotional or physical stress. We report the case of a 77-year-old male who was admitted to the hospital for complete heart block and developed TTC after pacemaker implantation. Read More
J Cardiol Cases 2011 Apr 16;3(2):e68-e70. Epub 2011 Feb 16.
Akdeniz University Faculty of Medicine, Cardiology Department, Dumlupinar Bouleward, Konyaaltı, Antalya, Turkey.
Duchenne muscular dystrophy is an X linked hereditary progressive neuromuscular disease and it is characterized by development of weakness and atrophy in affected muscles. In late phases of disease with involvement of respiratory and cardiac muscles, patients die because of respiratory and cardiac failure. Cardiomyopathy is a common complication and various types of arrhythmia because of conduction system involvement can be seen. Read More
J Cardiol Cases 2011 Apr 13;3(2):e65-e67. Epub 2011 Jan 13.
Cardiology Division, Department of Medicine, Cardiac Surgical Division, Department of Surgery, and Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Background: The importance of risk stratification for sudden cardiac death (SCD) after septal myectomy for hypertrophic obstructive cardiomyopathy (HOCM) has not been emphasized previously.
Methods And Results: We report 2 patients with SCD or ventricular tachycardia (VT) after septal myectomy for HOCM in whom risk factors for SCD were identified following surgical myectomy. One received an implantable cardioverter-defibrillator (ICD), which subsequently provided appropriate discharges for VT. Read More
J Cardiol Cases 2011 Feb 1;3(1):e33-e36. Epub 2011 Feb 1.
Division of Cardiology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.
Subarachnoid hemorrhage (SAH) often accompanies cardiac abnormalities. Sudden cardiac arrest is also known to occur after SAH. A 32-year-old woman was admitted to our hospital because of cardiac arrest immediately after the onset of SAH. Read More
J Cardiol Cases 2010 Dec 20;2(3):e119-e122. Epub 2010 Jun 20.
Division of Cardiology, Department of Internal Medicine, Social Insurance Kyoto Hospital, 27 Shimofusa-cho, Kita-ku, Kyoto 603-8151, Japan.
A 74-year-old female was admitted to our hospital due to prolonged chest pain that had lasted about 2 h. An electrocardiogram revealed ST-elevation in leads I, aVL, and V3-6, with an increase in myocardial necrosis markers. Emergency coronary angiography was performed, and left ventriculography showed the typical features of apical ballooning, and so a diagnosis of Takotsubo cardiomyopathy (TC) was made. Read More
Kidney Blood Press Res 2018 Dec 7;43(6):1865-1877. Epub 2018 Dec 7.
Department of Internal Cardiology Medicine, Faculty Hospital Brno, Faculty of Medicine, Masaryk University, Brno, Czech Republic.
Background/aims: The rate of incidence and prevalence of acute kidney injury is increasing due to an increased number of patients with heart failure. Therefore it is very pertinent to early detect the level of renal injuries and to make necessary heart failure predictions. Thus the aim of this study is to determine renal functions and prognosis stratification in chronic heart failure patients and importance of Neutrophil Gelatinase-Associated Lipocalin (NGAL), an early diagnostic marker of acute kidney injury, as well as stratification of cardiovascular risk in heart failure patients. Read More
Xenotransplantation 2018 Dec 11:e12479. Epub 2018 Dec 11.
Department of Surgery and Department of Microbiology & Immunology, University of Michigan, Ann Arbor, Michigan.
The newborn infant with severe cardiac failure owed to congenital structural heart disease or cardiomyopathy poses a daunting therapeutic challenge. The ideal solution for both might be cardiac transplantation if availability of hearts was not limiting and if tolerance could be induced, obviating toxicity of immunosuppressive therapy. If one could safely and effectively exploit neonatal tolerance for successful xenotransplantation of the heart, the challenge of severe cardiac failure in the newborn infant might be met. Read More
J Cell Physiol 2018 Dec 7. Epub 2018 Dec 7.
Department of Physiology, Faculty of Medicine, Cairo University, Giza, Egypt.
Wnt/β-catenin signaling pathway plays a crucial role in diabetic cardiomyopathy (DCM), thus we aimed at investigating the effect of one therapeutic approach with resveratrol (RSV) given systemically and combined treatment of RSV with mesenchymal stem cells (MSCs) that was either RSV-preconditioned or not on Wnt/β-catenin signaling pathway in streptozotocin-induced DCM, and to evaluate effects of RSV preconditioning on MSCs therapeutic potential. The rats were divided into control (C, n = 8), diabetic (DM, n = 8), diabetic treated with systemic RSV (DM-RSV, n = 8), diabetic treated with RSV and nonconditioned MSCs (DM-RSV-MSCs, n = 8), diabetic treated with RSV and RSV-incubated with MSCs (DM-RSV-MSCc, n = 8) and diabetic treated with RSV-conditioned MSCs (DM-MSCc, n = 8). Echocardiography (Echo) showed significant improvement of cardiac functions in all groups treated with RSV either systemic or added in culture media. Read More
Eur J Heart Fail 2018 Dec 10. Epub 2018 Dec 10.
Department of Medicine, University of Mississippi Medical Center, Jackson, MS, USA.
Multiple drug classes have shown incremental benefits in heart failure with reduced ejection fraction. Most of these trials were designed to achieve specific doses of the investigational agent. Clinical practice guidelines recommend using the same target dosing of therapies, as tolerated. Read More
Cochrane Database Syst Rev 2018 Dec 8;12:CD012738. Epub 2018 Dec 8.
Faculty of Medicine, American University of Beirut Medical Center, Beirut, Lebanon.
Background: There is evidence that implantable cardioverter-defibrillator (ICD) for primary prevention in people with an ischaemic cardiomyopathy improves survival rate. The evidence supporting this intervention in people with non-ischaemic cardiomyopathy is not as definitive, with the recently published DANISH trial finding no improvement in survival rate. A systematic review of all eligible studies was needed to evaluate the benefits and harms of using ICDs for primary prevention in people with non-ischaemic cardiomyopathy. Read More
Pediatr Transplant 2018 Dec 7:e13335. Epub 2018 Dec 7.
Department of Pediatrics (Cardiology), Stanford University Medical Center, Stanford University, Stanford, California.
Danon disease (DD) is an X-linked dominant disorder caused by a mutation in the lysosomal-associated membrane protein-2 (LAMP-2) gene coding for the LAMP-2 protein. We report two cases of successful heart transplantation (HT) in adolescent brothers with DD, including one who was bridged to HT for 34 days with a HeartWare left ventricular assist device. In both patients, the post-transplant course was complicated by profound skeletal muscle weakness that resolved with corticosteroid withdrawal. Read More
Diabetes Obes Metab 2018 Dec 11. Epub 2018 Dec 11.
Functional Metabolism Group, Singapore Bioimaging Consortium, Agency for Science, Technology, and Research, Singapore.
Aims: To investigate the effects of long-term low-carbohydrate low-protein ketogenic diet (KD) on cardiac metabolism and diabetic cardiomyopathy status in lean diabetic Goto-Kakizaki (GK) rats.
Materials And Methods: Diabetic GK rats were fed with KD for 62 weeks. Cardiac function and metabolism were assessed using magnetic resonance imaging and C magnetic resonance spectroscopy ( C-MRS), at rest and under dobutamine stress. Read More