117,150 results match your criteria Cardiomyopathy Restrictive


Mechanistic role of the CREB-regulated transcription coactivator 1 in cardiac hypertrophy.

J Mol Cell Cardiol 2018 Dec 3. Epub 2018 Dec 3.

Department of Clinical Pharmacology and Toxicology, Cardiovascular Research Center, University Medical Center Hamburg-Eppendorf, Martinistr. 52, 20246 Hamburg, Germany; DZHK (German Center for Cardiovascular Research), Partner Site Hamburg, Kiel, Lübeck, Germany; Institute of Pharmacy, University of Hamburg, Bundesstr. 45, 20146 Hamburg, Germany. Electronic address:

The sympathetic nervous system is the main stimulator of cardiac function. While acute activation of the β-adrenoceptors exerts positive inotropic and lusitropic effects by increasing cAMP and Ca, chronically enhanced sympathetic tone with changed β-adrenergic signaling leads to alterations of gene expression and remodeling. The CREB-regulated transcription coactivator 1 (CRTC1) is activated by cAMP and Ca. Read More

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December 2018
1 Read

Extracorporeal membrane oxygenation as a bridge for heart transplantation by Chagas cardiomyopathy

Rev Med Inst Mex Seguro Soc 2018 11 30;56(4):429-433. Epub 2018 Nov 30.

Instituto Mexicano del Seguro Social, Hospital de Cardiología, Servicio de Anestesiología. Ciudad de México, México

Background: Extracorporeal membrane oxygenation is a technique indicated in cases of severe respiratory failure or in situations where pump failure or heart failure is refractory to conventional medical treatment. Our goal was to describe the results of a patient with chronic Chagas dilated cardiomyopathy treated with extracorporeal membrane oxygenation as bridging therapy for heart transplantation.

Case Report: A 62-year old male with a history of Chagas disease and severe ventricular failure who underwent veno-arterial extracorporeal membrane oxygenation as bridging therapy for heart transplantation, with good clinical evolution. Read More

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November 2018
2 Reads

[Clinical applications of cardiac magnetic resonance imaging: heart failure and cardiomyopathies].

G Ital Cardiol (Rome) 2018 Dec;19(12):679-691

Dipartimento Cardiovascolare, ASST Papa Giovanni XXIII, Bergamo.

Cardiac magnetic resonance (CMR) has proved to be a powerful tool in the assessment of several cardiac diseases, thanks to its capability to offer multiparametric morphologic and functional evaluation of the heart and great vessels, using neither ionizing radiations nor nephrotoxic contrast medium. The accuracy in quantification of cardiac volumes and ejection fraction (gold standard) together with native and post-contrast myocardial tissue characterization have made CMR an invaluable tool for the diagnosis, prognosis and therapeutic planning in patients with heart failure and cardiomyopathy. Read More

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December 2018
2 Reads

Engineered Heart Slice Model of Arrhythmogenic Cardiomyopathy using Plakophilin-2 Mutant Myocytes.

Tissue Eng Part A 2018 Dec 6. Epub 2018 Dec 6.

Johns Hopkins University School of Medicine, Biomedical Engineering, Baltimore, Maryland, United States ;

Arrhythmogenic cardiomyopathy (AC), a cause of sudden cardiac death among young and otherwise healthy individuals, is a heritable disease that can be modeled in vitro using patient-specific cardiac myocytes (CMs) from induced pluripotent stem cells. An understanding of underlying disease mechanisms, particularly in the early concealed stages, could lead to new diagnosis and treatment strategies. However, multicellular syncytial models are needed to understand how genetically-encoded mutations of the desmosomes that interconnect cells lead to aberrant electrical conduction and arrhythmias. Read More

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December 2018

Diagnostic Value of HLA Typing in Pathogenesis of Cardiomyopathy.

Cardiovasc Hematol Disord Drug Targets 2018 Dec 5. Epub 2018 Dec 5.

Thalassemia and Hemoglobinopathy Research Center, Research Institute of Health, Ahvaz Jundishapur University of Medical Sciences, Ahvaz. Iran.

Development of cardiomyopathy (CM) is dependent upon several factors. However, reaction of immune response against myocardial tissue due to microbial and viral infections plays an important role in this disease. Therefore, the purpose of this study is to investigate the relationship between HLAs and their pathogenic mechanisms in the incidence of CM. Read More

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December 2018

Safety of Sports for Young Patients With Implantable Cardioverter-Defibrillators.

Circ Arrhythm Electrophysiol 2018 Nov;11(11):e006305

Yale University School of Medicine, New Haven, CT (J.D., C.B., L.S., F.L., R.J.L.).

Background: Despite safety concerns, many young patients with implantable cardioverter-defibrillators (ICDs) participate in sports. We undertook a prospective, multinational registry to determine the incidence of serious adverse events because of sports participation. The primary end points were death or resuscitated arrest during sports or injury during sports because of arrhythmia or shock. Read More

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November 2018

Astrocyte elevated gene-1 induces autophagy in diabetic cardiomyopathy through upregulation of KLF4.

J Cell Biochem 2018 Dec 5. Epub 2018 Dec 5.

Department of Pharmacy, Guangxi University of Chinese Medicine, Nanning, China.

Background: Astrocyte elevated gene-1 (AEG-1), also known as metadherin, 3D3, and lysine-rich carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) coisolated, has emerged as an important oncogene that is overexpressed in a variety of cancers. Previous studies revealed that AEG-1 is also involved in multiple physiological and pathological processes, such as development, inflammation, neurodegeneration, migraine, and Huntington's disease. However, the function of AEG-1 in diabetic cardiomyopathy (DCM) has not been reported yet. Read More

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December 2018

Hypertrophic obstructive cardiomyopathy and mitral regurgitation in Libman-Sacks endocarditis.

Gen Thorac Cardiovasc Surg 2018 Dec 5. Epub 2018 Dec 5.

Department of Cardiovascular Surgery, Mitsubishi Kyoto Hospital, 1 Goshomachi, Nishikyo-ku, Kyoto, 615-8087, Japan.

Hypertrophic obstructive cardiomyopathy in Libman-Sacks endocarditis is quite rare and the correct etiological relationship between them is unknown. Some changes may cause a secondary disorganization of the ordinary muscle structure, making a disarray pattern with irregular interwoven myocyte fibers. This case report describes one of the first cases of ventricular septal myectomy and mitral valve replacement for hypertrophic obstructive cardiomyopathy and mitral valve regurgitation associated with Libman-Sacks endocarditis. Read More

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December 2018

Pressure Overload Impairs Cardiac Function in Long-Chain Fatty Acid Transporter CD36-Knockout Mice.

Int Heart J 2018 Dec 5. Epub 2018 Dec 5.

Rinku General Medical Center.

CD36 is one of the important transporters of long-chain fatty acids (LCFAs) in the myocardium. We previously reported that CD36-deficient patients demonstrate a marked reduction of myocardial uptake of LCFA, while myocardial glucose uptake shows a compensatory increase, and are often accompanied by cardiomyopathy. However, the molecular mechanisms and functional role of CD36 in the myocardium remain unknown. Read More

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December 2018
2 Reads

Natriuretic Peptide Processing in Patients with and Without Left Ventricular Dysfunction.

Int Heart J 2018 Dec 5. Epub 2018 Dec 5.

Cardiovascular Center, Onze Lieve Vrouw Ziekenhuis.

This study aimed to examine the relationship between corin expression and circulating brain natriuretic peptide in patients with left ventricular (LV) dysfunction.Circulating levels of B-type natriuretic peptide (BNP) can be an indicator of LV dysfunction. The 32-amino-acid BNP is cleaved by corin, a cardiac serine protease, from its108-amino-acid pro-brain natriuretic peptide (proBNP) precursor. Read More

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December 2018

AAV CRISPR editing rescues cardiac and muscle function for 18 months in dystrophic mice.

JCI Insight 2018 Dec 6;3(23). Epub 2018 Dec 6.

Department of Molecular Microbiology and Immunology, School of Medicine, University of Missouri, Columbia, Missouri, USA.

Adeno-associated virus-mediated (AAV-mediated) CRISPR editing is a revolutionary approach for treating inherited diseases. Sustained, often life-long mutation correction is required for treating these diseases. Unfortunately, this has never been demonstrated with AAV CRISPR therapy. Read More

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December 2018

Converter domain mutations in myosin alter structural kinetics and motor function.

J Biol Chem 2018 Dec 5. Epub 2018 Dec 5.

Cellular and Molecular Physiology, Penn State University College of Medicine, United States.

Myosins are molecular motors that use a conserved ATPase cycle to generate force. We investigated two mutations in the converter domain of myosin V (R712G and F750L) to examine how altering specific structural transitions in the motor ATPase cycle can impair myosin mechanochemistry. The corresponding mutations in the human beta-cardiac myosin gene are associated with hypertrophic and dilated cardiomyopathy, respectively. Read More

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December 2018

CAP2 mutation leads to impaired actin dynamics and associates with supraventricular tachycardia and dilated cardiomyopathy.

J Med Genet 2018 Dec 5. Epub 2018 Dec 5.

The Shraga Segal Department of Microbiology, Immunology and Genetics, Faculty of Health Sciences, Ben Gurion University, Beer Sheva, Israel.

Background: Dilated cardiomyopathy (DCM) is a primary myocardial disease leading to contractile dysfunction, progressive heart failure and excessive risk of sudden cardiac death. Around half of DCM cases are idiopathic, and genetic factors seem to play an important role.

Aim: We investigated a possible genetic cause of DCM in two consanguineous children from a Bedouin family. Read More

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December 2018

A positive feedback regulation of Heme oxygenase 1 by CELF1 in cardiac myoblast cells.

Biochim Biophys Acta Gene Regul Mech 2018 Nov 30. Epub 2018 Nov 30.

National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China. Electronic address:

As an RNA binding protein, CUG-BP Elav-like family (CELF) has been shown to be critical for heart biological functions. However, no reports have revealed the function of CELF1 in hypertrophic cardiomyopathy (HCM). Hinted by RNA immunoprecipitation-sequencing (RIP-seq) data, the influence of the CELF protein on heme oxygenase-1 (HO-1) expression was tested by modulating CELF1 levels. Read More

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November 2018
1 Read

Right ventricular involvement in hypertrophic cardiomyopathy: patterns and implications.

Hellenic J Cardiol 2018 Nov 30. Epub 2018 Nov 30.

Unit of Inherited Cardiovascular Diseases/Heart Center of the Young and Athletes, First Department of Cardiology, Hippokration General Hospital, National and Kapodistrian University of Athens, Greece; National Heart and Lung Institute Imperial College London, London, UK.

Although hypertrophic cardiomyopathy (HCM) is the most common inherited cardiomyopathy worldwide, the criteria for its definition and most of the literature concern the left ventricle, confirming the theory that the right ventricle is the neglected one. Right ventricular (RV) involvement includes structural and functional changes with significant impact on clinical presentation and prognosis. The pattern of RV hypertrophy can be variable with possible dynamic obstruction. Read More

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November 2018

Microarray profiling analysis identifies the mechanism of miR-200b-3p/mRNA-CD36 affecting diabetic cardiomyopathy via peroxisome proliferator activated receptor-γ signaling pathway.

J Cell Biochem 2018 Dec 2. Epub 2018 Dec 2.

Department of Cardiology, The Affiliated Hospital of Southwest Medical University, Luzhou, China.

Objective: Current study focused on the influence of miR-200b-3p on cardiocyte apoptosis of diabetic cardiomyopathy (DCM) by regulating CD36 and peroxisome proliferator-activated receptor γ (PPAR-γ) signaling pathway.

Methods: Bioinformatic analysis was used to analyze differentially expressed microRNA (miRNAs), messenger RNAs (mRNAs) and activated pathways in DCM. And then quantitative real-time polymerase chain reaction (qRT-PCR) was conducted to verify expression of miR-200b-3p and CD36 in DCM model rats and glucose treated H9c2 cell line. Read More

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December 2018

Low expression of miR-186-5p regulates cell apoptosis by targeting toll-like receptor 3 in high glucose-induced cardiomyocytes.

J Cell Biochem 2018 Dec 3. Epub 2018 Dec 3.

Electrocardial Center of the First Affiliated Hospital of Jinzhou Medical University, Jinzhou, Liaoning, China.

To investigate the effect and mechanism of microRNA-186-5p (miR-186-5p) on the apoptosis in high glucose (HG)-treated cardiomyocytes. Diabetic cardiomyopathy model was established in cardiomyocytes by stimulating with HG. The expressions of miR-186-5p and toll-like receptor 3 (TLR3) were detected by quantitative polymerase chain reaction or Western blot analysis, respectively. Read More

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December 2018

A novel EMD mutation in a Chinese family with initial diagnosis of conduction cardiomyopathy.

Brain Behav 2018 Dec 3:e01167. Epub 2018 Dec 3.

Department of Medical Genetics, The Second Xiangya Hospital, Central South University, Changsha, China.

Introduction: Emery-Dreifuss muscular dystrophy (EDMD) is a hereditary myopathy characterized as triad of muscular dystrophy, joint contractures, and conduction cardiomyopathy. In this study, we diagnosed a X-linked recessive EDMD patient with severe conduction cardiomyopathy while noteless muscular and joint disorders.

Methods: A Chinese cardiomyopathy family spanning four generations was enrolled in the study. Read More

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December 2018
1 Read

Deciphering the SUMO code in the kidney.

J Cell Mol Med 2018 Dec 1. Epub 2018 Dec 1.

Department of Nephrology, The First Affiliated Hospital of Air Force Medical University, Xi'an, Shaanxi, China.

SUMOylation of proteins is an important regulatory element in modulating protein function and has been implicated in the pathogenesis of numerous human diseases such as cancers, neurodegenerative diseases, brain injuries, diabetes, and familial dilated cardiomyopathy. Growing evidence has pointed to a significant role of SUMO in kidney diseases such as DN, RCC, nephritis, AKI, hypertonic stress and nephrolithiasis. Recently, emerging studies in podocytes demonstrated that SUMO might have a protective role against podocyte apoptosis. Read More

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December 2018

Optimization of heart allocation: The transplant risk score.

Am J Transplant 2018 Dec 2. Epub 2018 Dec 2.

Agence de la Biomédecine Direction Prélèvement Greffe Organes-Tissus, Saint-Denis La Plaine, France.

The new French heart allocation system is designed to minimize waitlist mortality and extend the donor pool without a detrimental effect on post-transplant survival. This study was designed to construct a 1-year post-transplant graft-loss risk score incorporating recipient and donor characteristics. The study included all adult first single-organ recipients transplanted between 2010 and 2014 (N=1776). Read More

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December 2018
1 Read

Reverse takotsubo cardiomyopathy triggered by a multiple sclerosis relapse.

Acta Neurol Belg 2018 Nov 30. Epub 2018 Nov 30.

Department of Radiology, Université catholique de Louvain (UCLouvain), CHU UCL Namur, Yvoir, Belgium.

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November 2018
1 Read

Adrenocortical Carcinoma Presenting as Reversible Dilated Cardiomyopathy.

Heart Views 2018 Apr-Jun;19(2):71-73

Department of General Medicine, MES Medical College, Malappuram, Kerala, India.

We present a 32-year-old woman with no morbidities who was admitted with a dilated cardiomyopathy and cardiac failure due to adrenocortical carcinoma (ACC) which improved completely with surgical resection. Awareness regarding such rare presentations can avoid undue delay in diagnosis and management. Read More

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December 2018

Cardiac specific PRMT1 ablation causes heart failure through CaMKII dysregulation.

Nat Commun 2018 Nov 30;9(1):5107. Epub 2018 Nov 30.

Department of Molecular Cell Biology, Sungkyunkwan University School of Medicine, Suwon 16419, Korea.

Dysregulation of Ca/calmodulin-dependent protein kinase (CaMK)II is closely linked with myocardial hypertrophy and heart failure. However, the mechanisms that regulate CaMKII activity are incompletely understood. Here we show that protein arginine methyltransferase 1 (PRMT1) is essential for preventing cardiac CaMKII hyperactivation. Read More

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November 2018

Protein-Losing Enteropathy and Plastic Bronchitis After the Fontan Operation.

Authors:
Christine Peyton

Crit Care Nurse 2018 Dec;38(6):e5-e12

Christine Peyton is a clinical nurse specialist at the Heart Institute at Children's Hospital Colorado, Aurora, Colorado.

Protein-losing enteropathy and plastic bronchitis remain challenging to treat despite recent treatment advances. Protein-losing enteropathy and plastic bronchitis have been diagnosed in patients with cardiomyopathy, constrictive pericarditis, and congestive heart failure. This article focuses on patients with protein-losing enteropathy or plastic bronchitis following the Fontan procedure. Read More

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December 2018

[Bone seeking tracers' scintigraphy for the diagnosis of transthyretin cardiac amyloidosis].

Medicina (B Aires) 2018 ;78(6):395-398

Sección Medicina Nuclear, Servicio de Diagnóstico por Imágenes, Instituto Cardiovascular de Buenos Aires (ICBA), Buenos Aires, Argentina.

Transthyretin cardiac amyloidosis (ATTR) is a restrictive cardiomyopathy that leads to heart failure in considerable number of patients. Early diagnosis allows specific treatment options. However, ATTR diagnosis is complex and requires invasive procedures. Read More

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January 2018

Impact of Hypertrophic Cardiomyopathy on Prediction of Thromboembolism in Patients with Non-valvular Atrial Fibrillation.

Heart Rhythm 2018 Nov 29. Epub 2018 Nov 29.

Department of Cardiovascular and Internal Medicine, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan.

Background: Anticoagulation is recommended in hypertrophic cardiomyopathy (HCM) with non-valvular atrial fibrillation (NVAF) according to European and American guidelines. However, it is unclear whether HCM is a risk factor for thromboembolism in NVAF in Japan, and the management for NVAF with HCM is not established.

Objectives: We studied the impact of concomitant HCM on predicting thromboembolism in NVAF. Read More

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November 2018

Personality traits in patients with myocardial infarction with non-obstructive coronary arteries.

Am J Med 2018 Nov 29. Epub 2018 Nov 29.

Departments of Clinical Science and Education Södersjukhuset, Karolinska Institutet. Sjukhusbacken 10, 11883 Stockholm, Sweden.

Objective: To describe type A behavior pattern and trait anger in patient with myocardial infarction with non-obstructive coronary arteries (MINOCA) and compare them to patient with coronary heart disease and healthy controls. Type A behavior pattern and anger have been linked to coronary heart disease in previous studies. This is the first study to assess type A behavior pattern and trait anger in MINOCA patients. Read More

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November 2018

Trypanosoma cruzi immunoproteome: Calpain-like CAP5.5 differentially detected throughout distinct stages of human Chagas disease cardiomyopathy.

J Proteomics 2018 Nov 29. Epub 2018 Nov 29.

Laboratório de Biologia Celular, IOC, Fiocruz, Rio de Janeiro, RJ, Brazil. Electronic address:

Chagas disease, caused by the protozoan Trypanosoma cruzi, affects millions of people worldwide, especially in Latin America. Approximately 30% of the cases evolve to the chronic symptomatic stage due to cardiac and/or digestive damage, generally accompanied by nervous system impairment. Given the higher frequency and severity of clinical manifestations related to cardiac tissue lesion, the goal of this study was the identification of proteins associated with the disease progression towards its cardiac form. Read More

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November 2018

Recombinant human glucagon-like peptide-1 protects against chronic intermittent hypoxia by improving myocardial energy metabolism and mitochondrial biogenesis.

Mol Cell Endocrinol 2018 Nov 29. Epub 2018 Nov 29.

Department of Endocrinology, The Third Affiliated Hospital of Soochow University, Changzhou City, 213003, China. Electronic address:

Background And Aims: Obstructive sleep apnea syndrome is a chronic disease associated with intermittent hypoxia (IH) and is an important risk factor for cardiovascular disease. Glucagon-like peptide (GLP-1) is a naturally occurring incretin used as a promising therapeutic agent in the treatment of acute myocardial infarction, dilated cardiomyopathy, and advanced heart failure. However, whether GLP-1 can protect against IH-induced cardiac injury is still unclear. Read More

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November 2018

Evaluation of sepsis induced cardiac dysfunction as a predictor of mortality.

Cardiovasc Ultrasound 2018 Nov 30;16(1):31. Epub 2018 Nov 30.

MICU, St John's Medical College, Kormangala, Bangalore, 560034, India.

Background: Sepsis is characterized by life threatening organ dysfunction with dysregulated immune response. Cardiac dysfunction seen in sepsis is unique as it is reversible within 7-10 days. Initial study by Parker et al. Read More

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November 2018

Mourning and Takotsubo cardiomyopathy: neuroendocrine implications and nutritional management.

Rev Assoc Med Bras (1992) 2018 Oct;64(10):952-959

Senior Professor. Department of Nutrition and Health/UFV. Post-Graduation Program of Nutrition Sciences, Federal University of Viçosa, Viçosa (MG), Brasil.

This article aims to make reference to some recent mourning aspects considered risk factors for cardiovascular disease, specifically the Takotsubo cardiomyopathy. The objective was to describe the stress from the death of a loved one combining it to the possibility of occurrence of Takotsubo cardiomyopathy through the perception of a traumatic event by the cortex, which triggers the subcortical brain circuit affecting the endocrine response. Given the growing acknowledgement of this cardiomyopathy, it is possible to contextualize the nutritional behaviours and decisions surrounding it, whose benefits must exceed the condition of temporary cardiac dysfunction and extend to food choices that have some influence in the limbic system. Read More

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October 2018
3 Reads

The administration of high-mobility group box 1 fragment prevents deterioration of cardiac performance by enhancement of bone marrow mesenchymal stem cell homing in the delta-sarcoglycan-deficient hamster.

PLoS One 2018 5;13(12):e0202838. Epub 2018 Dec 5.

Department of Cardiovascular Surgery, Osaka University Graduate School of Medicine, Osaka, Japan.

Objectives: We hypothesized that systemic administration of high-mobility group box 1 fragment attenuates the progression of myocardial fibrosis and cardiac dysfunction in a hamster model of dilated cardiomyopathy by recruiting bone marrow mesenchymal stem cells thus causing enhancement of a self-regeneration system.

Methods: Twenty-week-old J2N-k hamsters, which are δ-sarcoglycan-deficient, were treated with systemic injection of high-mobility group box 1 fragment (HMGB1, n = 15) or phosphate buffered saline (control, n = 11). Echocardiography for left ventricular function, cardiac histology, and molecular biology were analyzed. Read More

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December 2018
2 Reads

Permanent His bundle pacing in heart failure patients: A systematic review and meta-analysis.

Pacing Clin Electrophysiol 2018 Dec 4. Epub 2018 Dec 4.

Department of Cardiology, First Affiliated Hospital, Nanjing Medical University, Nanjing, 210029, China.

Background: Cardiac resynchronization therapy (CRT) is the standard-of-care therapy for the patients with heart failure and left ventricular (LV) dyssynchrony. However, approximately 30% of patients show no response. Recent studies have shown that His bundle pacing (HBP) could be an alternative for the patients with CRT indications. Read More

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December 2018
3 Reads

Differential pacing from two sites to diagnose risk of ventricular arrhythmia and death.

Pacing Clin Electrophysiol 2018 Dec 4. Epub 2018 Dec 4.

Peter Munk Cardiac Centre, University Health Network, Toronto, ON, Canada.

Background: QRS abnormalities may not be apparent in sinus rhythm in electrically stable cardiomyopathy patients who can have quiescent but highly arrhythmogenic substrate. Here, we test the hypothesis that differential changes in QRS construction during right-ventricular apex pacing (RVP) as opposed to atrial pacing (AP) will identify latent substrate for ventricular arrhythmias (VA) and death.

Methods: Forty-patients with cardiomyopathy free of VA underwent baseline 114-electrode body-surface ECG during AP (100 bpm) and RVP (100 and 120 bpm). Read More

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December 2018
1 Read

Comparison of the dyssynchrony parameters recorded with gated SPECT in ischemic cardiomyopathy according to their repeatability at rest and to their ability to detect a synchrony reserve under dobutamine infusion.

J Nucl Cardiol 2018 Dec 4. Epub 2018 Dec 4.

Normandie Université, UNICAEN, Signalisation, électrophysiologie et imagerie des lésions d'ischémie-reperfusion myocardique, FHU REMOD-VHF, 14000, Caen, France.

Background: This study aimed to determine whether the repeatability of dyssynchrony assessment using gated myocardial perfusion SPECT (GSPECT) allows the detection of synchrony reserve during low-dose dobutamine infusion.

Methods And Results: Sixty-one patients with ischemic cardiomyopathy and LV ejection fraction < 50% were prospectively included in 10 centers. Each patient underwent two consecutive rest GSPECT with 99mTc-labeled tracer (either tetrofosmin or sestamibi) to assess the repeatability of LV function and dyssynchrony parameters, followed by a GSECT acquisition during low-dose dobutamine infusion. Read More

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December 2018

Imaging cardiac amyloidosis: Patient page.

J Nucl Cardiol 2018 Dec 4. Epub 2018 Dec 4.

Cardiac Amyloidosis Program, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA.

Amyloidosis is a disease that develops when abnormally folded proteins collect together to form amyloid fibrils, which deposit in various organs and cause organ damage. Amyloidosis in the heart can be identified by using various imaging tests. This patient page provides an overview of imaging in cardiac amyloidosis. Read More

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December 2018
7 Reads

Left Ventricular Diastolic Dysfunction in a Rat Model of Diabetic Cardiomyopathy using ECG-gated F-FDG PET.

Sci Rep 2018 Dec 4;8(1):17631. Epub 2018 Dec 4.

Department of Nuclear Medicine, University Hospital Wuerzburg, Wuerzburg, Germany.

In diabetic cardiomyopathy, left ventricular (LV) diastolic dysfunction is one of the earliest signs of cardiac involvement prior to the definitive development of heart failure (HF). We aimed to explore the LV diastolic function using electrocardiography (ECG)-gated F-fluorodeoxyglucose positron emission tomography (F-FDG PET) imaging beyond the assessment of cardiac glucose utilization in a diabetic rat model. ECG-gated F-FDG PET imaging was performed in a rat model of type 2 diabetes (ZDF fa/fa) and ZL control rats at age of 13 weeks (n = 6, respectively). Read More

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December 2018

Cardiomyopathie du péri-partum.

Rev Prat 2017 Apr;67(4):421-423

Service de cardiologie, centre hospitalier universitaire Ibn Rochd, Casablanca, Maroc.

Peripartum cardiomyopathy. Peripartum cardiomyopathy (PPCM) is a dilated cardiomyopathy occurring during or following pregnancy in the absence of pre-existing heart disease. The aetiology is still uncertain. Read More

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April 2017
2 Reads

Comprehensive human stem cell differentiation in a 2D and 3D mode to cardiomyocytes for long-term cultivation and multiparametric monitoring on a multimodal microelectrode array setup.

Biosens Bioelectron 2018 Oct 29;126:624-631. Epub 2018 Oct 29.

Centre for Biotechnology and Biomedicine, Universität Leipzig, Division of Molecular Biological-Biochemical Processing Technology, Germany. Electronic address:

Human pluripotent stem cell derived cardiomyocytes are a promising cell source for research and clinical applications like investigation of cardiomyopathies and therefore, identification and testing of novel therapeutics as well as for cell based therapy approaches. However, actually it´s a challenge to generate matured adult cardiomyocyte-like phenotype in a reasonable time. Moreover, there is a lack of applicable non-invasive label-free monitoring techniques providing quantitative parameters for analysing the culture stability and maturation status. Read More

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October 2018

Development of induced pluripotent stem cells from a patient with hypertrophic cardiomyopathy who carries the pathogenic myosin heavy chain 7 mutation p.Arg403Gln.

Stem Cell Res 2018 Nov 28;33:269-273. Epub 2018 Nov 28.

Agnes Ginges Centre for Molecular Cardiology, Centenary Institute, Sydney, Australia; Sydney Medical School, University of Sydney, Sydney, Australia; Department of Cardiology, Royal Prince Alfred Hospital, Sydney, Australia. Electronic address:

Hypertrophic cardiomyopathy (HCM) is an inherited cardiomyopathy characterized by left ventricular hypertrophy ≥15 mm in the absence of loading conditions. HCM has a prevalence of up to one in 200, and can result in significant adverse outcomes including heart failure and sudden cardiac death. An induced pluripotent stem cell (iPSC) line was generated from peripheral blood mononuclear cells obtained from the whole blood of a 38-year-old female patient with HCM in which genetic testing identified the well-known pathogenic p. Read More

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November 2018

Expanding clinical phenotype in CACNA1C related disorders: From neonatal onset severe epileptic encephalopathy to late-onset epilepsy.

Am J Med Genet A 2018 Dec 4. Epub 2018 Dec 4.

Division of Pediatric Neurology, Department of Neurology, University of Washington, Seattle, Washington.

CACNA1C (NM_000719.6) encodes an L-type calcium voltage-gated calcium channel (Ca 1.2), and pathogenic variants have been associated with two distinct clinical entities: Timothy syndrome and Brugada syndrome. Read More

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December 2018
1 Read

Association of Renin-Angiotensin Inhibitor Treatment With Mortality and Heart Failure Readmission in Patients With Transcatheter Aortic Valve Replacement.

JAMA 2018 Dec;320(21):2231-2241

Duke Clinical Research Institute, Duke University Medical Center, Durham, North Carolina.

Importance: Data are lacking on the effect of a renin-angiotensin system (RAS) inhibitor prescribed after transcatheter aortic valve replacement (TAVR). Treatment with a RAS inhibitor may reverse left ventricular remodeling and improve function.

Objective: To investigate the association of prescription of a RAS inhibitor and outcomes after TAVR. Read More

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December 2018
1 Read

Melatonin protects against streptozotocin-induced diabetic cardiomyopathy by the phosphorylation of vascular endothelial growth factor-A (VEGF-A).

Cell Mol Biol (Noisy-le-grand) 2018 Nov 30;64(14):47-52. Epub 2018 Nov 30.

Department of Emergency Medicine, Antalya Education and Research Hospital, Antalya, Turkey.

The aim of the present study is to investigate if the melatonin has any protective effect on diabetic cardiomyopathy and antioxidant enzymes via phosphorylation of vascular endothelial growth factor-A (VEGF-A). A total of 40 male Wistar rats were enrolled in the study. Rats were divided into four groups: group 1 (control, n=10), group 2 (DM, n=10), group 3 (melatonin, n=10), and group 4 (melatonin+DM, n=10). Read More

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November 2018
2 Reads

A novel mutation of the MYH7 gene in a patient with hypertrophic cardiomyopathy.

Turk J Pediatr 2018 ;60(3):315-318

Division of Cardiothoracic Surgery, Department of Surgery, Saint Louis University School of Medicine, St. Louis, MO, USA.

Goel N, Huddleston CB, Fiore AC. A novel mutation of the MYH7 gene in a patient with hypertrophic cardiomyopathy. Turk J Pediatr 2018; 60: 315-318. Read More

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January 2018
2 Reads

Thymoquinone Attenuates Cardiomyopathy in Streptozotocin-Treated Diabetic Rats.

Oxid Med Cell Longev 2018 30;2018:7845681. Epub 2018 Oct 30.

Pharmaceutical Research Institute, Albany College of Pharmacy and Health Sciences, Rensselaer, NY 12144, USA.

Diabetic cardiomyopathy is a diabetic complication due to oxidative stress injuries. This study examined the protecting influence of thymoquinone (TQ) on diabetes-caused cardiac complications. The intracellular means by which TQ works against diabetes-caused cardiac myopathy in rats is not completely understood. Read More

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October 2018
2 Reads

Takotsubo syndrome complicated by thrombus formation.

Authors:
Kenta Zaikokuji

Asian Cardiovasc Thorac Ann 2018 Dec 3:218492318816220. Epub 2018 Dec 3.

Department of Cardiovascular Surgery, Heart Valve Center, Komaki City Hospital, Komaki-City, Aichi, Japan.

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December 2018

Successful treatment of drug-induced esophageal ulcer in a patient with chronic heart failure: A case report.

Medicine (Baltimore) 2018 Nov;97(48):e13380

Department of Gastroenterology and Hepatology.

Rationale: Although esophageal compression due to cardiomegaly may be a risk factor of drug-induced esophageal injuries (DIEIs), the causal relationship between the two conditions has not been fully demonstrated.

Patient Concerns: We present a case of a drug-induced esophageal ulcer caused by left atrial enlargement in a 44-year-old woman with end-stage hypertrophic cardiomyopathy. Upper gastrointestinal endoscopy showed a deep, circumferential ulcer in the middle thoracic esophagus. Read More

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November 2018
3 Reads

Letter regarding the article 'Heart failure with preserved ejection fraction: from mechanisms to therapies' by Lam and colleagues.

Eur Heart J 2018 Nov 29. Epub 2018 Nov 29.

Department of Internal Medicine, University of Genova, Genova, Italy.

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November 2018
2 Reads