22,146 results match your criteria Cardiomyopathy Dilated


The inhibitory subunit of cardiac troponin (cTnI) is modified by arginine methylation in the human heart.

Int J Cardiol 2019 Jan 31. Epub 2019 Jan 31.

Biomedical Sciences, University of Hull, Cottingham Rd, HU6 7RX Hull, UK. Electronic address:

Background: The inhibitory subunit of cardiac troponin (cTnI) is a gold standard cardiac biomarker and also an essential protein in cardiomyocyte excitation-contraction coupling. The interactions of cTnI with other proteins are fine-tuned by post-translational modification of cTnI. Mutations in cTnI can lead to hypertrophic cardiomyopathy. Read More

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http://dx.doi.org/10.1016/j.ijcard.2019.01.102DOI Listing
January 2019

Hazards of ventricular pre-excitation to left ventricular systolic function and ventricular wall motion in children: analysis of 25 cases.

Cardiol Young 2019 Feb 15:1-9. Epub 2019 Feb 15.

Department of Pediatric Cardiology,Beijing Anzhen Hospital,Capital Medical University,Beijing100029,China.

AimThe aim was to attach importance to the hazards of ventricular pre-excitation on left ventricular systolic function and size. METHOD: We analysed the clinical, electrophysiological, and echocardiographic characteristics of the 25 cases with abnormal ventricular wall motion, left ventricular systolic dysfunction, or dilation with co-existing right-sided overt accessary pathways before and after ablation or medication during March 2011 and June 2017. Moreover, we compared the therapy effect between patients with ventricular pre-excitation-induced dilated cardiomyopathy and idiopathic dilated cardiomyopathy without ventricular pre-excitation. Read More

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http://dx.doi.org/10.1017/S1047951118002500DOI Listing
February 2019

American Heart Association 2018 Scientific Sessions.

Authors:
Walter Alexander

P T 2019 Jan;44(2):48-63

We report on sessions on the dapagliflozin effect on cardiovascular events; angiotensin receptor-neprilysin inhibition for acute decompensated heart failure; rivaroxaban's effect on thromboembolic events with heart failure, sinus rhythm, and coronary disease; trial results on the withdrawal of pharmacological heart failure therapy in recovered dilated cardiomyopathy; and more from AHA's November meeting. Read More

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January 2019

Non-familial cardiomyopathies in Lebanon: exome sequencing results for five idiopathic cases.

BMC Med Genomics 2019 Feb 14;12(1):33. Epub 2019 Feb 14.

Department of Biochemistry and Molecular Genetics, American University of Beirut Faculty of Medicine and Medical Center (AUBMC), Phase I, 8th floor, Room C-823, PO Box 11-0236, Riad El-Solh, Beirut, 1107 2020, Lebanon.

Background: Cardiomyopathies affect more than 0.5% of the general population. They are associated with high risk of sudden cardiac death, which can result from either heart failure or electrical abnormalities. Read More

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http://dx.doi.org/10.1186/s12920-019-0478-7DOI Listing
February 2019

Distinct molecular signature of phospholamban p.Arg14del arrhythmogenic cardiomyopathy.

Cardiovasc Pathol 2018 Dec 21;40:2-6. Epub 2018 Dec 21.

University of Groningen, University Medical Center Groningen, Department of Pathology, Groningen, The Netherlands.

Phospholamban (PLN) p.Arg14del cardiomyopathy is characterized by a distinct arrhythmogenic biventricular phenotype that can be predominantly left ventricular, right ventricular, or both. Our aim was to further elucidate distinct features of this cardiomyopathy with respect to the distribution of desmosomal proteins observed by immunofluorescence (IF) in comparison to desmosomal arrhythmogenic cardiomyopathy and co-existent genetic variants. Read More

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http://dx.doi.org/10.1016/j.carpath.2018.12.006DOI Listing
December 2018

Targeting MRTF/SRF in CAP2-dependent dilated cardiomyopathy delays disease onset.

JCI Insight 2019 Feb 14. Epub 2019 Feb 14.

About one-third of dilated cardiomyopathy (DCM) cases are caused by mutations in sarcomere or cytoskeletal proteins. Yet treating the cytoskeleton directly is not possible because drugs that bind to actin are not well tolerated. Mutations in the actin binding protein CAP2 can cause DCM and knockout mice, either whole body (CAP2 KO) or cardiomyocyte-specific knockouts (CAP2 CKO), develop DCM with cardiac conduction disease. Read More

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http://dx.doi.org/10.1172/jci.insight.124629DOI Listing
February 2019

Prevalence of pathogenic and likely pathogenic variants in the RASopathy genes in patients who have had panel testing for cardiomyopathy.

Am J Med Genet A 2019 Feb 14. Epub 2019 Feb 14.

Division of Human Genetics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.

RASopathies are a group of developmental disorders caused by pathogenic variants in the RAS-MAPK pathway. Cardiomyopathy is a major feature of this group of disorders, specifically hypertrophic cardiomyopathy (HCM). HCM can be the first presenting feature in individuals with RASopathies. Read More

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http://dx.doi.org/10.1002/ajmg.a.61072DOI Listing
February 2019

Enterovirus Persistence in Cardiac Cells of Patients Suffering From Idiopathic Dilated Cardiomyopathy is Linked to 5' Terminal Genomic RNA-Deleted Viral Populations With Viral-Encoded Proteinase Activities.

Circulation 2019 Feb 13. Epub 2019 Feb 13.

Medical and Molecular Virology EA4684, Laboratoire de Virologie médicale et moléculaire, et EA-4684, Hôpital Robert Debré, France.

Background: Group B enteroviruses are common causes of acute myocarditis which can be a precursor of chronic myocarditis and dilated cardiomyopathy (DCM), leading causes of heart transplantation. To date, the specific viral functions involved in the development of DCM remain unclear.

Methods: Total RNA from cardiac tissue of patients suffering from DCM was extracted, and sequences corresponding to the 5' termini of enterovirus RNAs were identified. Read More

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http://dx.doi.org/10.1161/CIRCULATIONAHA.118.035966DOI Listing
February 2019

Neutrophil-to-lymphocyte ratio used as prognostic factor marker for dilated cardiomyopathy in childhood and adolescence.

Ann Pediatr Cardiol 2019 Jan-Apr;12(1):18-24

Department of Pediatrics, Division of Pediatric Cardiology, Hospital das Clínicas, Federal University of Minas Gerais, Belo Horizonte, Brazil.

Objective: The objective of this study is to evaluate the neutrophil-to-lymphocyte ratio (NLR) and platelet-lymphocyte ratio, from the hemograms obtained from children and adolescents with dilated cardiomyopathy (DCM), and to correlate them with the levels of B-type natriuretic peptide (BNP) and with the clinical evolution of these patients in the long term.

Materials And Methods: Follow-up of 57 patients with DCM was made retrospectively, with hemogram and BNP level determination being performed after optimized therapy for heart failure. We compared the findings of the patients' examinations that progressed with stability in relation to the occurrence of transplant listing, cardiac transplantation, or evolution to death. Read More

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http://dx.doi.org/10.4103/apc.APC_47_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343383PMC
February 2019
1 Read

PKC and PKN in heart disease.

J Mol Cell Cardiol 2019 Feb 8;128:212-226. Epub 2019 Feb 8.

Division of Cardiology, School of Medicine, University of California-San Diego, La Jolla, USA; University of Gothenburg, Wallenberg Laboratory, Department of Molecular and Clinical Medicine, Institute of Medicine, Gothenburg, Sweden. Electronic address:

The protein kinase C (PKC) and closely related protein kinase N (PKN) families of serine/threonine protein kinases play crucial cellular roles. Both kinases belong to the AGC subfamily of protein kinases that also include the cAMP dependent protein kinase (PKA), protein kinase B (PKB/AKT), protein kinase G (PKG) and the ribosomal protein S6 kinase (S6K). Involvement of PKC family members in heart disease has been well documented over the years, as their activity and levels are mis-regulated in several pathological heart conditions, such as ischemia, diabetic cardiomyopathy, as well as hypertrophic or dilated cardiomyopathy. Read More

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http://dx.doi.org/10.1016/j.yjmcc.2019.01.029DOI Listing
February 2019
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LncEGFL7OS regulates human angiogenesis by interacting with MAX at the EGFL7/miR-126 locus.

Elife 2019 Feb 11;8. Epub 2019 Feb 11.

Department of Cell and Molecular Biology, Tulane University, New Orleans, United States.

In an effort to identify human endothelial cell (EC)-enriched lncRNAs,~500 lncRNAs were shown to be highly restricted in primary human ECs. Among them, , located in the opposite strand of the gene, is regulated by ETS factors through a bidirectional promoter in ECs. It is enriched in highly vascularized human tissues, and upregulated in the hearts of dilated cardiomyopathy patients. Read More

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http://dx.doi.org/10.7554/eLife.40470DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6370342PMC
February 2019
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Genomic Reorganization of Lamin-Associated Domains in Cardiac Myocytes is Associated with Differential Gene Expression and DNA Methylation in Human Dilated Cardiomyopathy.

Circ Res 2019 Feb 11. Epub 2019 Feb 11.

Center for Cardiovascular Genetics, The University of Texas Health Sciences Center at Houston.

Rationale: Lamin A/C (LMNA), a nuclear membrane protein, interacts with genome through lamin-associated domains (LADs) and regulates gene expression. Mutations in the LMNA gene cause a diverse array of diseases, including dilated cardiomyopathy (DCM). DCM is the leading cause of death in laminopathies. Read More

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http://dx.doi.org/10.1161/CIRCRESAHA.118.314177DOI Listing
February 2019
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Relationship between left ventricular vortex and preejectional flow velocity during isovolumic contraction studied by using vector flow mapping.

Echocardiography 2019 Feb 6. Epub 2019 Feb 6.

Department of Ultrasound, PLA 967th Hospital, Dalian, China.

Objectives: The purpose of this study was to investigate the relationship between the vortex in left ventricle (LV) during the isovolumic contraction (IVC) period and the preejectional flow velocity in LV outflow tract (V ).

Methods: Color Doppler loops were acquired for vector flow mapping in apical long-axis view in 76 patients with dilated cardiomyopathy, 61 patients with coronary artery disease and 36 healthy controls.

Results: All normals exhibited an IVC vortex reaching the LV base. Read More

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http://dx.doi.org/10.1111/echo.14277DOI Listing
February 2019
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Mitral Valve Prosthesis Design Affects Hemodynamic Stasis and Shear In The Dilated Left Ventricle.

Ann Biomed Eng 2019 Feb 6. Epub 2019 Feb 6.

Bioengineering Program, San Diego State University, 5500 Campanile Dr, San Diego, CA, 92182-1323, USA.

Dilated cardiomyopathy produces abnormal left ventricular (LV) blood flow patterns that are linked with thromboembolism (TE). We hypothesized that implantation of mechanical heart valves non-trivially influences TE risk in these patients, exacerbating abnormal LV flow dynamics. The goal of this study was to assess how mitral valve design impacts flow and hemodynamic factors associated with TE. Read More

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http://dx.doi.org/10.1007/s10439-019-02218-zDOI Listing
February 2019
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RNA sequencing discloses the genome‑wide profile of long noncoding RNAs in dilated cardiomyopathy.

Mol Med Rep 2019 Feb 5. Epub 2019 Feb 5.

Department of Cardiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, P.R. China.

Dilated cardiomyopathy (DCM) is a common type of non‑ischemic cardiomyopathy, of which the underlying mechanisms have not yet been fully elucidated. Long noncoding RNAs (lncRNAs) have been reported to serve crucial physiological roles in various cardiac diseases. However, the genome‑wide expression profile of lncRNAs remains to be elucidated in DCM. Read More

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http://dx.doi.org/10.3892/mmr.2019.9937DOI Listing
February 2019
2 Reads

Adiponectin deficiency has no effect in murine autoimmune myocarditis.

Cytokine 2019 Apr 1;116:139-149. Epub 2019 Feb 1.

Department of Cardiology, University of Heidelberg, Heidelberg, Germany. Electronic address:

Background: Adiponectin is a hormone that together with its receptors modulates a number of metabolic processes including gluconeogenesis and lipid catabolism. It belongs to the C1QTNF (complement C1q tumor necrosis factor-related protein) family, which has a variety of members with high amino acid sequence homology and overlapping functions. Concentration of adiponectin in blood is inversely correlated with body fat percentage and cardiac risk factors like blood pressure and CRP (C-reactive protein) level. Read More

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http://dx.doi.org/10.1016/j.cyto.2018.12.022DOI Listing
April 2019
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Plasma levels of melatonin in dilated cardiomyopathy.

J Pineal Res 2019 Feb 4:e12564. Epub 2019 Feb 4.

Department of Cardiovascular Medicine.

Background: Melatonin is a multifunctional indolamine, and has a cardioprotective role in a variety of cardiovascular processes via antioxidant, anti-inflammatory, anti-hypertensive, anti-thrombotic and anti-lipemic effects. It has been reported that lower levels of circulating melatonin are significantly associated with a higher risk of acute myocardial infarction (AMI) and later cardiac remodeling. However, levels of melatonin in patients with dilated cardiomyopathy (DCM) and associations between melatonin levels and cardiac function remain unclear. Read More

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http://dx.doi.org/10.1111/jpi.12564DOI Listing
February 2019
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A missense variant in the titin gene in Doberman pinscher dogs with familial dilated cardiomyopathy and sudden cardiac death.

Hum Genet 2019 Feb 4. Epub 2019 Feb 4.

Department of Physiology, University of Arizona, Tucson, AZ, 85724, USA.

The dog provides a large animal model of familial dilated cardiomyopathy for the study of important aspects of this common familial cardiovascular disease. We have previously demonstrated a form of canine dilated cardiomyopathy in the Doberman pinscher breed that is inherited as an autosomal dominant trait and is associated with a splice site variant in the pyruvate dehydrogenase kinase 4 (PDK4) gene, however, genetic heterogeneity exists in this species as well and not all affected dogs have the PDK4 variant. Whole genome sequencing of a family of Doberman pinchers with dilated cardiomyopathy and sudden cardiac death without the PDK4 variant was performed. Read More

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http://dx.doi.org/10.1007/s00439-019-01973-2DOI Listing
February 2019
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Titin truncations lead to impaired cardiomyocyte autophagy and mitochondrial function in vivo.

Hum Mol Genet 2019 Feb 4. Epub 2019 Feb 4.

Cardiovascular & Metabolic Disorders Program, Duke-National University of Singapore, Singapore 169857, Singapore.

Titin-truncating variants (TTNtv) are the most common genetic cause of dilated cardiomyopathy (DCM). TTNtv occur in ~1% of the general population and causes subclinical cardiac remodeling in asymptomatic carriers. In rat models with either proximal or distal TTNtv, we previously showed altered cardiac metabolism at baseline and impaired cardiac function in response to stress. Read More

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https://academic.oup.com/hmg/advance-article/doi/10.1093/hmg
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http://dx.doi.org/10.1093/hmg/ddz033DOI Listing
February 2019
2 Reads

Autophagy and Oncosis/Necroptosis Are Enhanced in Cardiomyocytes from Heart Failure Patients.

Med Sci Monit Basic Res 2019 Feb 4;25:33-44. Epub 2019 Feb 4.

Center for Heart and Vessel Preclinical Studies, Department of Internal Medicine, St. John Hospital and Medical Center, Wayne State University, Detroit, MI, USA.

BACKGROUND Although originally described as a survival mechanism, it is unknown whether and to what extent autophagy is implicated in the terminal stages of heart failure. Here, we studied magnitude and evolution of autophagy in patients with intractable heart failure. MATERIAL AND METHODS Myocardial samples were obtained from 22 patients with ischemic cardiomyopathy and idiopathic dilated cardiomyopathy who were undergoing cardiac transplantation. Read More

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https://basic.medscimonit.com/abstract/index/idArt/913436
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http://dx.doi.org/10.12659/MSMBR.913436DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6373236PMC
February 2019
2 Reads

rAAVrh74.MCK.GALGT2 Protects against Loss of Hemodynamic Function in the Aging mdx Mouse Heart.

Mol Ther 2019 Jan 15. Epub 2019 Jan 15.

Center for Gene Therapy, The Research Institute at Nationwide Children's Hospital, 700 Children's Drive, Columbus, OH 43205, USA; Department of Pediatrics, Department of Physiology and Cell Biology, The Ohio State University College of Medicine, Columbus, OH 43210, USA. Electronic address:

Dilated cardiomyopathy is a common cause of death in patients with Duchenne muscular dystrophy (DMD). Gene therapies for DMD must, therefore, have a therapeutic impact in cardiac as well as skeletal muscles. Our previous studies have shown that GALGT2 overexpression in mdx skeletal muscles can prevent muscle damage. Read More

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http://dx.doi.org/10.1016/j.ymthe.2019.01.005DOI Listing
January 2019
1 Read

Novel role of mitochondrial GTPases 1 in pathological cardiac hypertrophy.

J Mol Cell Cardiol 2019 Jan 29;128:105-116. Epub 2019 Jan 29.

Department of Cardiology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China. Electronic address:

While most mitochondrial proteins are encoded in the nucleus and translated on cytosolic/endoplasmic reticulum ribosomes, proteins encoded by mitochondrial DNA are translated on mitochondrial ribosomes. Mitochondrial GTPases 1 (MTG1) regulates mitochondrial ribosome assembly and translation, but its impact on cardiac adaptation to stress is unknown. Here, we found that MTG1 is dramatically elevated in hearts of dilated cardiomyopathy patients and in mice exposed to left ventricular pressure overload (AB). Read More

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http://dx.doi.org/10.1016/j.yjmcc.2019.01.025DOI Listing
January 2019
2 Reads
4.655 Impact Factor

[Cardiomyopathy in a 22-year-old man with a long history of methamphetamine abuse].

Internist (Berl) 2019 Feb 1. Epub 2019 Feb 1.

Klinik für Kardiologie, Angiologie und Pneumologie, Innere Medizin III, Medizinische Klinik, Universitätsklinikum Heidelberg, Im Neuenheimer Feld 410, 69120, Heidelberg, Deutschland.

This article presents the case of a 22-year-old male patient with cardiomyopathy associated with a long history of methamphetamine abuse. Echocardiography revealed a dilated cardiomyopathy with highly reduced systolic pump function and severe mitral valve regurgitation. Inotropic treatment and MitraClip® (Abbott Vascular, Santa Clara, CA, USA) implantation resulted in enhancement of hemodynamics. Read More

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http://link.springer.com/10.1007/s00108-019-0559-x
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http://dx.doi.org/10.1007/s00108-019-0559-xDOI Listing
February 2019
2 Reads

Hereditary heart disease: pathophysiology, clinical presentation, and animal models of HCM, RCM, and DCM associated with mutations in cardiac myosin light chains.

Pflugers Arch 2019 Jan 31. Epub 2019 Jan 31.

Department of Molecular and Cellular Pharmacology, University of Miami Miller School of Medicine, 1600 NW 10th Ave., Miami, FL, 33136, USA.

Genetic cardiomyopathies, a group of cardiovascular disorders based on ventricular morphology and function, are among the leading causes of morbidity and mortality worldwide. Such genetically driven forms of hypertrophic (HCM), dilated (DCM), and restrictive (RCM) cardiomyopathies are chronic, debilitating diseases that result from biomechanical defects in cardiac muscle contraction and frequently progress to heart failure (HF). Locus and allelic heterogeneity, as well as clinical variability combined with genetic and phenotypic overlap between different cardiomyopathies, have challenged proper clinical prognosis and provided an incentive for identification of pathogenic variants. Read More

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http://dx.doi.org/10.1007/s00424-019-02257-4DOI Listing
January 2019
1 Read
4.101 Impact Factor

-mutated Rabbits: A Model of Premature Aging Syndrome with Muscular Dystrophy and Dilated Cardiomyopathy.

Aging Dis 2019 Feb 1;10(1):102-115. Epub 2019 Feb 1.

1Jilin Provincial Key Laboratory of Animal Embryo Engineering, Jilin University, Changchun 130062, China.

Premature aging syndromes are rare genetic disorders mimicking clinical and molecular features of aging. Products of the gene, primarily lamin A and C, are major components of the nuclear lamina. A recently identified group of premature aging syndromes was related to mutations of the gene. Read More

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http://dx.doi.org/10.14336/AD.2018.0209DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6345340PMC
February 2019
2 Reads

Contemporary characteristics and outcomes of adults with familial dilated cardiomyopathy listed for heart transplantation.

World J Cardiol 2019 Jan;11(1):38-46

Cardiology Section, Department of Internal Medicine, University Hospitals Cleveland Medical Center, Harrington Heart and Vascular Institute, Cleveland, OH 44106, United States.

Background: Familial dilated cardiomyopathy (FDCM) account for 20%-30% of non-ischemic cardiomyopathies (NICM). Previous published data showed that some patients with FDCM tend to have rapidly progressive disease; however, five-year mortality was not significantly different in the familial and non-familial forms of NICM with optimal medical therapy.

Aim: To better define the characteristics and clinical outcomes of FDCM patients listed for heart transplantation (HT). Read More

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http://dx.doi.org/10.4330/wjc.v11.i1.38DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354074PMC
January 2019
1 Read

Heart disease in Friedreich's ataxia.

World J Cardiol 2019 Jan;11(1):1-12

Department of Internal Medicine, Cardiology Section, University of New Mexico, Albuquerque, NM 87106, United States.

Friedreich's ataxia (FRDA), which occurs in 1/50000 live births, is the most prevalent inherited neuromuscular disorder. Nearly all FRDA patients develop cardiomyopathy at some point in their lives. The clinical manifestations of FRDA include ataxia of the limbs and trunk, dysarthria, diabetes mellitus, and cardiac diseases. Read More

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http://dx.doi.org/10.4330/wjc.v11.i1.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354072PMC
January 2019
1 Read

Cardiac Dysfunction Among People Living With HIV: A Systematic Review and Meta-Analysis.

JACC Heart Fail 2019 Feb;7(2):98-108

South African Medical Research Council and University of Cape Town, South Africa.

Objective: To synthesize existing epidemiological data on cardiac dysfunction in HIV.

Background: Data on the burden and risk of human immunodeficiency virus (HIV) infection-associated cardiac dysfunction have not been adequately synthesized. We performed meta-analyses of extant literature on the frequency of several subtypes of cardiac dysfunction among people living with HIV. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22131779183076
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http://dx.doi.org/10.1016/j.jchf.2018.10.006DOI Listing
February 2019
3 Reads

Anomalous Left Coronary Artery From the Pulmonary Artery Presenting as Dilated Cardiomyopathy With Regional Wall Motion Abnormality on Point-of-Care Ultrasound.

Pediatr Emerg Care 2019 Jan 29. Epub 2019 Jan 29.

Department of Emergency Medicine, Highland Hospital, Alameda Health System, Oakland, CA.

Anomalous left coronary artery from the pulmonary artery is a rare cause of dilated cardiomyopathy. We present the first reported case of anomalous left coronary artery from the pulmonary artery diagnosed by point-of-care ultrasound, leading to expedited management, stabilization, and eventual treatment. Read More

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http://dx.doi.org/10.1097/PEC.0000000000001741DOI Listing
January 2019
1 Read

Immediate extubation after heart transplantation in a child by remifentanil-based ultra-fast anesthesia: A case report.

Medicine (Baltimore) 2019 Feb;98(5):e14348

Rationale: Ventilator-associated complications comprise important fatal aetiologies during heart transplantation. Ultra-fast anesthesia might provide the most effective measure to prevent this type of complication. Immediate extubation after heart transplantation (IEAHT) has recently been reported in adult patients. Read More

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http://dx.doi.org/10.1097/MD.0000000000014348DOI Listing
February 2019
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Predictors of community-acquired pneumonia in patients with acute decompensated heart failure: the results of the analysis of the hospital sample EPOHA-D-CHF.

Ter Arkh 2018 Apr;90(4):35-41

Nizhny Novgorod State Medical Academy, Ministry of Health of Russia, Nizhny Novgorod, Russia.

Aim: Identify the most significant predictors of community-acquired pneumonia and their im-pact on the risk of this disease in patients with ADHF.

Materials And Methods: The analysis of the hospital sample of patients (n=852) with ADHF. In 16. Read More

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http://dx.doi.org/10.26442/terarkh201890435-41DOI Listing
April 2018
1 Read

Pattern and Presentation of Thyro-Cardiac Disease among Patients with Hyperthyroidism Attending a Tertiary Hospital in Ethiopia: A Cross Sectional Study.

Ethiop J Health Sci 2019 Jan;29(1):887-894

Department of Internal Medicine, Cardiology Unit, St. Paul's Hospital Millennium Medical College, Addis Ababa, Ethiopia.

Background: Thyro-cardiac disease describes the existence of a combination of thyroid toxicity and significant heart disease in an individual patient. The frequent manifestations of thyro-cardiac disease are hypertension, atrial flutter or fibrillation, pulmonary hypertension and dilated cardiomyopathy. The aim of the study was to determine the pattern and presentation of cardiovascular diseases in patients with hyperthyroidism on follow-up at St. Read More

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http://dx.doi.org/10.4314/ejhs.v29i1.10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341434PMC
January 2019
1 Read

Myocardial-specific ablation of () leads to dilated cardiomyopathy in mice.

J Biol Chem 2019 Jan 30. Epub 2019 Jan 30.

Cell and Regenerative Biology, University of Wisconsin-Madison, United States.

Cardiomyopathy is a common myocardial disease that can lead to sudden death. However, molecular mechanisms underlying cardiomyopathy remains unclear. Jarid2 is necessary for embryonic heart development, but functions of Jarid2 after birth remains to be elucidated. Read More

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http://dx.doi.org/10.1074/jbc.RA118.005634DOI Listing
January 2019
1 Read

Peripartum cardiomyopathy.

BMJ 2019 Jan 30;364:k5287. Epub 2019 Jan 30.

Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.

Peripartum cardiomyopathy (PPCM) is a rare, often dilated, cardiomyopathy with systolic dysfunction that presents in late pregnancy or, more commonly, the early postpartum period. Although the condition is prevalent worldwide, women with black ancestry seem to be at greatest risk, and the condition has a particularly high incidence in Nigeria and Haiti. Other risk factors include pre-eclampsia, advanced maternal age, and multiple gestation pregnancy. Read More

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http://www.bmj.com/lookup/doi/10.1136/bmj.k5287
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http://dx.doi.org/10.1136/bmj.k5287DOI Listing
January 2019
3 Reads

Deleting Full Length Titin Versus the Titin M-Band Region Leads to Differential Mechanosignaling and Cardiac Phenotypes.

Circulation 2019 Jan 31. Epub 2019 Jan 31.

Neuromuscular and Cardiovascular Cell Biology, Max-Delbrueck-Center, Germany.

Background: Titin is a giant elastic protein that spans the half-sarcomere from Z-disk to M-band. It acts as a molecular spring and mechanosensor and has been linked to striated muscle disease. The pathways that govern titin dependent cardiac growth and contribute to disease are diverse and difficult to dissect. Read More

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http://dx.doi.org/10.1161/CIRCULATIONAHA.118.037588DOI Listing
January 2019
1 Read

Sudden Death and Left Ventricular Involvement in Arrhythmogenic Cardiomyopathy.

Circulation 2019 Jan 31. Epub 2019 Jan 31.

Cardiovascular pathology, Cardiovascular Pathology Unit, St Georges Hospital Medical School, London, UK, United Kingdom.

Background: Arrhythmogenic cardiomyopathy (ACM) is an inherited heart muscle disorder characterized by myocardial fibro-fatty replacement and an increased risk of sudden cardiac death (SCD). Originally described as a right ventricular (RV) disease, ACM is increasingly recognized as a biventricular entity. We evaluated pathological, genetic, and clinical associations in a large SCD cohort. Read More

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http://dx.doi.org/10.1161/CIRCULATIONAHA.118.037230DOI Listing
January 2019
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Incidence and risk factors associated with development of clinical cardiotoxicity in dogs receiving doxorubicin.

J Vet Intern Med 2019 Jan 29. Epub 2019 Jan 29.

Department of Clinical Sciences, North Carolina State University, College of Veterinary Medicine, Raleigh, North Carolina.

Background: Doxorubicin (DOX) can cause cumulative cardiotoxicity in dogs, but the incidence of clinical cardiotoxicity in dogs receiving DOX has not been determined.

Hypothesis/objectives: To determine if the duration of DOX infusion influences the incidence of cardiotoxicity, to characterize the incidence of clinical cardiotoxicity in dogs during or after DOX chemotherapy, and to identify any risk factors associated with cardiotoxicity.

Animals: Four-hundred ninety-four dogs that received at least 1 dose of DOX for the treatment of cancer. Read More

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http://dx.doi.org/10.1111/jvim.15414DOI Listing
January 2019
1 Read

Potential Utility of Protein Targets of Cysteine-S-Nitrosylation in Identifying Clinical Disease Status in Human Chagas Disease.

Front Microbiol 2018 15;9:3320. Epub 2019 Jan 15.

Institute for Human Infections and Immunity, University of Texas Medical Branch (UTMB), Galveston, TX, United States.

infection causes Chagas disease (ChD) presented by dilated cardiomyopathy and heart failure. During infection, oxidative and nitrosative stresses are elicited by the immune cells for control the pathogen; however, excess nitric oxide and superoxide production can result in cysteine S-nitrosylation (SNO) of host proteins that affects cellular homeostasis and may contribute to disease development. To identify the proteins with changes in SNO modification levels as a hallmark of ChD, we obtained peripheral blood mononuclear cells (PBMC) from seronegative, normal healthy (NH, = 30) subjects, and from seropositive clinically asymptomatic (ChD CA, = 25) or clinically symptomatic (ChD CS, = 28) ChD patients. Read More

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http://dx.doi.org/10.3389/fmicb.2018.03320DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340995PMC
January 2019
2 Reads

DNA Damage Response/TP53 Pathway Is Activated and Contributes to the Pathogenesis of Dilated Cardiomyopathy Associated with Lamin A/C Mutations.

Circ Res 2019 Jan 30. Epub 2019 Jan 30.

Center for Cardiovascular Genetics, University of Texas Health Sciences Center at Houston.

Rationale: Mutations in the LMNA gene, encoding lamin A/C (LMNA), are responsible for laminopathies. Dilated cardiomyopathy (DCM) is a major cause of mortality and morbidity in laminopathies.

Objective: To gain insights into the molecular pathogenesis of DCM in laminopathies. Read More

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https://www.ahajournals.org/doi/10.1161/CIRCRESAHA.118.31423
Publisher Site
http://dx.doi.org/10.1161/CIRCRESAHA.118.314238DOI Listing
January 2019
13 Reads

The feasibility of a novel limited field of view spiral cine DENSE sequence to assess myocardial strain in dilated cardiomyopathy.

MAGMA 2019 Jan 29. Epub 2019 Jan 29.

National Heart Lung Institute, Imperial College London, London, UK.

Objective: Develop an accelerated cine displacement encoding with stimulated echoes (DENSE) cardiovascular magnetic resonance (CMR) sequence to enable clinically feasible myocardial strain evaluation in patients with dilated cardiomyopathy (DCM).

Materials And Methods: A spiral cine DENSE sequence was modified by limiting the field of view in two dimensions using in-plane slice-selective pulses in the stimulated echo. This reduced breath hold duration from 20RR to 14RR intervals. Read More

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http://dx.doi.org/10.1007/s10334-019-00735-5DOI Listing
January 2019
1 Read

Dilated cardiomyopathy with endocardial fibroelastosis in a juvenile Pallas cat.

J Vet Diagn Invest 2019 Jan 29:1040638719827061. Epub 2019 Jan 29.

Departments of Biomedical Sciences and Pathobiology (Gudenschwager, LeRoith), Virginia-Maryland College of Veterinary Medicine, Virginia Tech, Blacksburg, VA.

Dilated cardiomyopathy (DCM) is a myocardial disease characterized by ventricular chamber dilation associated with systolic myocardial dysfunction in the absence of other cardiac lesions. DCM occasionally develops in conjunction with proliferation of fibroelastic fibers in the endocardium, producing endocardial fibroelastosis (EFE). Although early reports describe EFE as a primary disease, evidence now suggests that EFE may develop as a response to myocardial dysfunction. Read More

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http://dx.doi.org/10.1177/1040638719827061DOI Listing
January 2019
1 Read

Impact of cardiac myosin light chain kinase gene mutation on development of dilated cardiomyopathy.

ESC Heart Fail 2019 Jan 28. Epub 2019 Jan 28.

Department of Cardiovascular and Internal Medicine, Kanazawa University Graduate School of Medicine, Kanazawa, Japan.

Aims: Cardiac myosin light chain kinase (cMLCK) phosphorylates ventricular myosin regulatory light chain 2 (MLC2v) and regulates sarcomere and cardiomyocyte organization. However, few data exist regarding the relationship between cMLCK mutations and MLC2v phosphorylation, particularly in terms of developing familial dilated cardiomyopathy (DCM) in whom cMLCK gene mutations were identified. The purpose of the present study was to investigate functional consequences of cMLCK mutations in DCM patients. Read More

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http://dx.doi.org/10.1002/ehf2.12410DOI Listing
January 2019
2 Reads

Identification of six cardiovascular risk biomarkers in the young population: A promising tool for early prevention.

Atherosclerosis 2019 Jan 14;282:67-74. Epub 2019 Jan 14.

Immunoallergy and Proteomics Laboratory, Department of Immunology, IIS-Fundación Jiménez Díaz, UAM, Madrid, Spain; REDINREN, Madrid, Spain. Electronic address:

Background And Aims: The predictive value of traditional CV risk calculators is limited. Novel indicators of CVD progression are needed particularly in the young population. The main aim of this study was the identification of a molecular profile with added value to classical CV risk estimation. Read More

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http://dx.doi.org/10.1016/j.atherosclerosis.2019.01.003DOI Listing
January 2019
1 Read

Multiple ICD shocks in a patient with dilated cardiomyopathy: What is the mechanism?

J Cardiovasc Electrophysiol 2019 Jan 28. Epub 2019 Jan 28.

Department of Cardiology, Cardiac Electrophysiology Unit, University Hospital 12 de Octubre, Madrid, Spain.

We present the case of a 45-year-old male patient with dilated cardiomyopathy who suffers from multiple implantable cardioverter defibrillator (ICD) shocks. The analysis of the ICD tracing and the electrophysiological study allows to conclude that bundle branch re-entrant tachycardia is the most likely diagnosis, even in absence of conduction abnormalities in his basal electrocardiography. Read More

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http://dx.doi.org/10.1111/jce.13862DOI Listing
January 2019
1 Read

Prognosis and risk stratification in patients with decompensated heart failure receiving inotropic therapy.

Open Heart 2018 6;5(2):e000923. Epub 2018 Dec 6.

Internal Medicine Department, Centro Hospitalar de São João, Porto, Portugal.

Objectives: The prognostic significance of transient use of inotropes has been sufficiently studied in recent heart failure (HF) populations. We hypothesised that risk stratification in these patients could contribute to patient selection for advanced therapies.

Methods: We analysed a prospective cohort of adult patients admitted with decompensated HF and ejection fraction (left ventricular ejection fraction (LVEF)) less than 50%. Read More

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http://dx.doi.org/10.1136/openhrt-2018-000923DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330199PMC
December 2018
1 Read

[Research on the knockout of LMNA gene by CRISPR/Cas9 system in human cell lines].

Yi Chuan 2019 Jan;41(1):66-75

Department of Cell Biology and Genetics, Basic Medical College, Guangxi Medical University, Nanning 530021, China.

The LMNA gene encodes the nuclear Lamin A and Lamin C proteins, and is related to nuclear membrane organization, genome stability and cell differentiation. Abnormal expression of LMNA is ubiquitous in human tumors, and its mutation leads to various forms of laminopathies, including Emery-Dreifuss muscular dystrophy (EDMD), dilated cardiomyopathy (DCM), and Hutchinson-Gliford progeria syndrome (HGPS). To further determine the functions of the LMNA gene in cellular physiology, the present study used the CRISPR/Cas9 technique to edit the LMNA gene of 293T and HepG2 cells in vitro, which resulted in two stable LMNA gene knockout (LMNA KO) cell lines. Read More

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http://dx.doi.org/10.16288/j.yczz.18-146DOI Listing
January 2019
6 Reads

Heart rate reduction strategy using ivabradine in end-stage Duchenne cardiomyopathy.

Int J Cardiol 2019 Apr 17;280:99-103. Epub 2019 Jan 17.

Department of Pediatric Cardiology and Cardiac Surgery, Cardiology Unit, Bambino Gesù Hospital & Research Institute, Rome, Italy.

Background: End-stage dilated cardiomyopathy (DCM) is the leading cause of morbidity and mortality in patients with Duchenne Muscular Dystrophy (DMD). No studies are available on the effect of ivabradine on long-term outcomes in end-stage DMD/DCM.

Methods: We prospectively enrolled a cohort of end-stage DMD/DCM patients with LV ejection fraction <40%, on chronic HF treatment with an ACE inhibitor referred consecutively from 2012 to 2017 to Bambino Gesù Children's Hospital. Read More

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http://dx.doi.org/10.1016/j.ijcard.2019.01.052DOI Listing
April 2019
1 Read

Targeted next-generation sequencing in Slovak cardiomyopathy patients.

Bratisl Lek Listy 2019 ;120(1):46-51

Objectives: For the first time we used targeted next-generation sequencing to detect candidate pathogenic variants in Slovak cardiomyopathy patients.

Background: Targeted next-generation sequencing is considered to be the best practice in genetic diagnostics of cardiomyopathies. However, in Slovakia, with high cardiomyopathies prevalence of 1/440, the current diagnostic tests are still based on Sanger sequencing of a few genes. Read More

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http://dx.doi.org/10.4149/BLL_2019_007DOI Listing
January 2019
1 Read