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    Examination of Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) as a Potential Biomarker in Heart Failure Patients.
    J Mol Neurosci 2018 Jan 20. Epub 2018 Jan 20.
    Department of Anatomy, MTA-PTE PACAP Research Team, Centre for Neuroscience, Medical School, University of Pecs, Szigeti Street 12, Pecs, 7624, Hungary.
    Pituitary adenylate cyclase-activating polypeptide (PACAP) is a pleiotropic and multifunctional neuropeptide having neurotrophic, neuroprotective, and general cytoprotective actions in a variety of tissues based on its anti-apoptotic, anti-inflammatory, and antioxidant effects. Several studies have demonstrated its cardioprotective effects in vitro and in various animal models. However, few data are available on the presence of PACAP in human cardiac tissues and its role in the pathomechanism and progression of different cardiac disorders, particularly heart failure. Read More

    Membranous glomerulonephritis with an LMNA mutation.
    CEN Case Rep 2018 Jan 18. Epub 2018 Jan 18.
    Department of General Medicine, Tenri Hospital, 200 Mishima-cho, Tenri, Nara, Japan.
    We had encountered the case of membranous glomerulonephritis (MGN) with dilated cardiomyopathy due to LMNA gene mutation. LMNA mutation was known as a cause of 'laminopathy' such as dilated cardiomyopathy, muscular dystrophy, neuropathy and so on. LMNA gene might be a candidate of genetic basis in cryptogenic MGN. Read More

    Cardiomyocyte-Restricted Low Density Lipoprotein Receptor-Related Protein 6 (LRP6) Deletion Leads to Lethal Dilated Cardiomyopathy Partly Through Drp1 Signaling.
    Theranostics 2018 1;8(3):627-643. Epub 2018 Jan 1.
    Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, and Institutes of Biomedical Sciences, Fudan University, Shanghai 200032, China.
    Low density lipoprotein receptor-related protein 6 (LRP6), a wnt co-receptor, regulates multiple functions in various organs. However, the roles of LRP6 in the adult heart are not well understood. Methods: We observed LRP6 expression in heart with end-stage dilated cardiomyopathy (DCM) by western blot. Read More

    Angiotensin II Overstimulation Leads to an Increased Susceptibility to Dilated Cardiomyopathy and Higher Mortality in Female Mice.
    Sci Rep 2018 Jan 17;8(1):952. Epub 2018 Jan 17.
    Research Center, Montreal Heart Institute, 5000 Bélanger, Montréal, Québec, Canada.
    Heart failure (HF) is associated with high mortality and affects men and women differently. The underlying mechanisms for these sex-related differences remain largely unexplored. Accordingly, using mice with cardiac-specific overexpression of the angiotensin II (ANGII) type 1 receptor (AT1R), we explored male-female differences in the manifestations of hypertrophy and HF. Read More

    Circulating microRNA signature for the diagnosis of childhood dilated cardiomyopathy.
    Sci Rep 2018 Jan 15;8(1):724. Epub 2018 Jan 15.
    Beijing Anzhen Hospital, Capital Medical University, Beijing, China.
    Circulating miRNAs are proposed as a biomarker of heart disease. This study evaluated whether circulating miRNAs could be used as a biomarker for childhood dilated cardiomyopathy (CDCM). A total of 28 participants were enrolled in a discovery set, including patients with CDCM (n = 16) and healthy children (n = 12). Read More

    Serelaxin for infant heart failure in congenital dilated cardiomyopathy.
    Cardiol Young 2018 Jan 15:1-3. Epub 2018 Jan 15.
    3Unit of Pediatric Cardiology,Children's University Hospital Geneva& Faculty of Medicine,Geneva,Switzerland.
    Serelaxin has been studied in trials in adults with acute heart failure, but not in children. We report the first compassionate use of serelaxin in an infant. A 6-month-old girl with dilated cardiomyopathy was placed on extracorporeal membrane oxygenation following cardiac arrest unresponsive to medical treatment. Read More

    Insertional Mutagenesis Confounds the Mechanism of the Morbid Phenotype of a PLNR9C Transgenic Mouse Line.
    J Card Fail 2018 Jan 8. Epub 2018 Jan 8.
    University of Toronto; 27 King's College Circle, Toronto, Ontario, Canada M5S 1A1. Electronic address:
    Background: A mouse line with heterozygous transgenic expression of phospholamban carrying a substitution of cysteine for arginine 9 (TgPLNR9C) under the control of α-myosin heavy chain (αMHC) promoter features dilated cardiomyopathy, heart failure and premature death.

    Methods And Results: Determination of transgene chromosomal localization by conventional methods shows that in this line the transgenic array of 13 PLNR9C expression cassettes, arranged in a head-to-tail tandem orientation, has integrated into the bi-directional promoter of the αMHC (Myh6) gene and the gene for the regulatory non-coding RNA Myheart (Mhrt), both of which are known to be involved in cardiac development and pathology. Expression of the non-coding RNA Mhrt in TgPLNR9C mice exhibits a profound deregulation, despite the presence of the second, intact allele. Read More

    Haplo-insufficiency of Bcl2-associated Athanogene 3 in Mice Results in Progressive Left Ventricular Dysfunction, β-Adrenergic Insensitivity and Increased Apoptosis.
    J Cell Physiol 2018 Jan 11. Epub 2018 Jan 11.
    Department of Medicine, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA.
    Bcl2-associated athanogene 3 (BAG3) is a 575 amino acid protein that is found predominantly in the heart, skeletal muscle and many cancers. Deletions and truncations in BAG3 that result in haplo-insufficiency have been associated with the development of dilated cardiomyopathy. To study the cellular and molecular events attributable to BAG3 haplo-insufficiency we generated a mouse in which one allele of BAG3 was flanked by loxP recombination sites (BAG3fl/+ ). Read More

    Histological and morphometric analysis of dilated cardiomyopathy with special reference to collagen IV expression.
    Indian J Pathol Microbiol 2017 Oct-Dec;60(4):481-486
    Department of Pathology, All India Institute of Medical Sciences, New Delhi, India.
    Introduction: Collagen distribution alterations are well known in dilated cardiomyopathy. There are also changes in microvasculature along with other histomorphorphological features.

    Aims And Objectives: To study the histomorphological features of DCM along with their quantitative correlation with LVEF. Read More

    Myocardium of patients with dilated cardiomyopathy presents altered expression of genes involved in thyroid hormone biosynthesis.
    PLoS One 2018 10;13(1):e0190987. Epub 2018 Jan 10.
    Cardiocirculatory Unit, Health Research Institute of La Fe University Hospital (IIS La Fe), Valencia, Spain.
    Background: The association between dilated cardiomyopathy (DCM) and low thyroid hormone (TH) levels has been previously described. In these patients abnormal thyroid function is significantly related to impaired left ventricular (LV) function and increased risk of death. Although TH was originally thought to be produced exclusively by the thyroid gland, we recently reported TH biosynthesis in the human ischemic heart. Read More

    The Role of Serum Adiponectin for Outcome Prediction in Patients with Dilated Cardiomyopathy and Advanced Heart Failure.
    Biomed Res Int 2017 26;2017:3818292. Epub 2017 Nov 26.
    Department of Pathology, Forensic Medicine and Pharmacology, Faculty of Medicine, Vilnius University, M. K. Ciurlionio 21, LT-03101 Vilnius, Lithuania.
    Clinical interpretation of patients' plasma adiponectin (APN) remains challenging; its value as biomarker in dilated cardiomyopathy (DCM) is equivocal. We evaluated whether circulating APN level is an independent predictor of composite outcome: death, left ventricle assist device (LVAD) implantation, and heart transplantation (HT) in patients with nonischemic DCM. 57 patients with nonischemic DCM (average LV diastolic diameter 6. Read More

    Force Generation via β-Cardiac Myosin, Titin, and α-Actinin Drives Cardiac Sarcomere Assembly from Cell-Matrix Adhesions.
    Dev Cell 2018 Jan 8;44(1):87-96.e5. Epub 2018 Jan 8.
    Department of Biomedical Engineering, Boston University, Boston, MA 02215, USA; The Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA 02115, USA. Electronic address:
    Truncating mutations in the sarcomere protein titin cause dilated cardiomyopathy due to sarcomere insufficiency. However, it remains mechanistically unclear how these mutations decrease sarcomere content in cardiomyocytes. Utilizing human induced pluripotent stem cell-derived cardiomyocytes, CRISPR/Cas9, and live microscopy, we characterize the fundamental mechanisms of human cardiac sarcomere formation. Read More

    Cardiac resynchronization therapy in patients with end-stage hypertrophic cardiomyopathy.
    Europace 2018 Jan;20(1):82-88
    Department of Cardiovascular Diseases.
    Aims: A dilated/end-stage phase of hypertrophic cardiomyopathy (HCM) is rare but well-recognized. The role for cardiac resynchronization therapy (CRT) in this subset of patients remains unexplored. We aimed to clarify the impact of bi-ventricular pacing CRT in dilated/end-stage HCM. Read More

    White blood cell differentials in dogs with congestive heart failure (CHF) in comparison to those in dogs without cardiac disease.
    J Small Anim Pract 2018 Jan 4. Epub 2018 Jan 4.
    Cardiology Service, Small Animal Teaching Hospital, Institute of Veterinary Science, University of Liverpool, Neston, Chester, CH64 7TE, UK.
    Objectives: To determine if dogs with congestive heart failure have different white blood cell differential cell counts than dogs without cardiac disease.

    Materials And Methods: In total, 72 dogs with congestive heart failure and 143 controls were included in this retrospective study. Signalment, white blood cell differential counts and echocardiography data were retrieved. Read More

    Cardiomyocyte Hypocontractility and Reduced Myofibril Density in End-Stage Pediatric Cardiomyopathy.
    Front Physiol 2017 22;8:1103. Epub 2017 Dec 22.
    Department of Physiology, Amsterdam Cardiovascular Sciences, VU University Medical Center, Amsterdam, Netherlands.
    Dilated cardiomyopathy amongst children (pediatric cardiomyopathy, pediatric CM) is associated with a high morbidity and mortality. Because little is known about the pathophysiology of pediatric CM, treatment is largely based on adult heart failure therapy. The reason for high morbidity and mortality is largely unknown as well as data on cellular pathomechanisms is limited. Read More

    Putative functional genes in idiopathic dilated cardiomyopathy.
    Sci Rep 2018 Jan 8;8(1):66. Epub 2018 Jan 8.
    Center for Bioinformatics and Computational Biology, University of Maryland, College Park, Maryland, 20742, USA.
    Idiopathic dilated cardiomyopathy (DCM) is a complex disorder with a genetic and an environmental component involving multiple genes, many of which are yet to be discovered. We integrate genetic, epigenetic, transcriptomic, phenotypic, and evolutionary features into a method - Hridaya, to infer putative functional genes underlying DCM in a genome-wide fashion, using 213 human heart genomes and transcriptomes. Many genes identified by Hridaya are experimentally shown to cause cardiac complications. Read More

    Coronary Embolism Among ST-Segment-Elevation Myocardial Infarction Patients: Mechanisms and Management.
    Circ Cardiovasc Interv 2018 Jan;11(1):e005587
    From the Département de Cardiologie (B.P., N.B., S.P., C.H.M., P.A.M., C.S.S., Y.J., E.C.) and Epidémiologie et Evaluation Cliniques (N.A.), CHU Nancy, France.
    Background: Coronary artery embolism (CE) is recognized as an important nonatherosclerotic cause of ST-segment-elevation myocardial infarction. The objective was to describe clinical characteristics and long-term outcomes and to identify risks factors of CE in a large consecutive series of ST-segment-elevation myocardial infarction patients.

    Methods And Results: We studied 1232 consecutive patients who presented with de novo ST-segment-elevation myocardial infarction. Read More

    Genome-Wide Analysis of Starvation-Selected Drosophila melanogaster-A Genetic Model of Obesity.
    Mol Biol Evol 2018 Jan;35(1):50-65
    School of Life Sciences, University of Nevada Las Vegas, Las Vegas, NV.
    Experimental evolution affords the opportunity to investigate adaptation to stressful environments. Studies combining experimental evolution with whole-genome resequencing have provided insight into the dynamics of adaptation and a new tool to uncover genes associated with polygenic traits. Here, we selected for starvation resistance in populations of Drosophila melanogaster for over 80 generations. Read More

    Coupling interval variability of premature ventricular contractions in patients with different underlying pathology: an insight into the arrhythmia mechanism.
    J Interv Card Electrophysiol 2018 Jan 5. Epub 2018 Jan 5.
    Department of Cardiology, Electrophysiology, Erasmus Medical Center, Rotterdam, The Netherlands.
    Purpose: Coupling interval (CI) variability of premature ventricular contractions (PVCs) is influenced by the underlying arrhythmia mechanism. The aim of this study was to compare CI variability of PVCs in different myocardial disease entities, in order to gain insight into their arrhythmia mechanism.

    Methods: Sixty-four patients with four underlying pathologies were included: idiopathic (n = 16), non-ischemic dilated cardiomyopathy (NIDCM) (n = 16), familial cardiomyopathy (PLN/LMNA) (n = 16), and post-MI (n = 16)-associated PVCs. Read More

    Muscle-Specific Mis-Splicing and Heart Disease Exemplified by RBM20.
    Genes (Basel) 2018 Jan 5;9(1). Epub 2018 Jan 5.
    Animal Science, University of Wyoming, Laramie, WY 82071, USA.
    Alternative splicing is an essential post-transcriptional process to generate multiple functional RNAs or proteins from a single transcript. Progress in RNA biology has led to a better understanding of muscle-specific RNA splicing in heart disease. The recent discovery of the muscle-specific splicing factor RNA-binding motif 20 (RBM20) not only provided great insights into the general alternative splicing mechanism but also demonstrated molecular mechanism of how this splicing factor is associated with dilated cardiomyopathy. Read More

    J Zoo Wildl Med 2017 Dec;48(4):1077-1080
    Eleven cases of dilated cardiomyopathy have been diagnosed and treated in captive Livingstone fruit bats ( Pteropus livingstonii) in the United Kingdom over the past 7 yr. All but one case received treatment with a diuretic plus an angiotensin-converting enzyme inhibitor (ACEI), and, or pimobendan. One case is still under treatment with pimobendan alone, following diagnosis before onset of clinical signs. Read More

    Endocardial fibroelastosis in two related tiger cubs (Panthera tigris).
    J Vet Cardiol 2017 Dec 28. Epub 2017 Dec 28.
    University of Tennessee Veterinary Medical Center, 2407 River Drive, Knoxville, TN 37996, USA.
    Two tiger cubs (Panthera tigris) from the same litter were evaluated for suspected cardiac disease. Two cubs with a dilated cardiomyopathy phenotype were diagnosed with endocardial fibroelastosis based on necropsy and histopathologic examinations. Echocardiography revealed salient anatomic and functional aspects of this cardiac disorder. Read More

    Gene expression analysis to identify mechanisms underlying heart failure susceptibility in mice and humans.
    Basic Res Cardiol 2017 Dec 29;113(1). Epub 2017 Dec 29.
    Cardiology and Angiology I, Heart Center, Freiburg University, Hugstetter Str. 55, 79106, Freiburg, Germany.
    Genetic factors are known to modulate cardiac susceptibility to ventricular hypertrophy and failure. To determine how strain influences the transcriptional response to pressure overload-induced heart failure (HF) and which of these changes accurately reflect the human disease, we analyzed the myocardial transcriptional profile of mouse strains with high (C57BL/6J) and low (129S1/SvImJ) susceptibility for HF development, which we compared to that of human failing hearts. Following transverse aortic constriction (TAC), C57BL/6J mice developed overt HF while 129S1/SvImJ did not. Read More

    PDK4 Deficiency Induces Intrinsic Apoptosis in Response to Starvation in Fibroblasts from Doberman Pinschers with Dilated Cardiomyopathy.
    Biores Open Access 2017 1;6(1):182-191. Epub 2017 Dec 1.
    Department of Pediatrics, College of Medicine, University of Florida, Gainesville, Florida.
    The Doberman pinscher (DP) canine breed displays a high incidence of idiopathic, nonischemic dilated cardiomyopathy (DCM) with increased mortality. A common mutation in DPs is a splice site deletion in the pyruvate dehydrogenase kinase 4 (PDK4) gene that shows a positive correlation with DCM development. PDK4, a vital mitochondrial protein, controls the switch between glycolysis and oxidative phosphorylation based upon nutrient availability. Read More

    Omega-3 polyunsaturated fatty acids prevent murine dilated cardiomyopathy by reducing oxidative stress and cardiomyocyte apoptosis.
    Exp Ther Med 2017 Dec 18;14(6):6152-6158. Epub 2017 Oct 18.
    Department of Cardiology, Affiliated Zhongshan Hospital of Dalian University, Dalian, Liaoning 116000, P.R. China.
    Mice that lacked manganese-superoxide dismutase (Mn-SOD) activity exhibited the typical pathology of dilated cardiomyopathy (DCM). The aim of the present study was to investigate the effect of supplementation with omega-3 polyunsaturated fatty acids (n-3 PUFA) on heart function and oxidative stress biomarkers in mice with DCM. In the present study, heart/muscle-specific Mn-SOD-deficient mice (H/M-Sod2-/-) were treated with n-3 PUFA (30 mg/kg/day) for 10 weeks, and the reactive oxygen species (ROS) production in their heart mitochondria and cardiac function was subsequently assessed. Read More

    Anesthetic Management of a Patient with Dilated Cardiomyopathy and End-stage Renal Disease for Emergency Strangulated Hernia Repair Surgery.
    Anesth Essays Res 2017 Oct-Dec;11(4):1121-1123
    Department of Anesthesia, SGPGI, Lucknow, Uttar Pradesh, India.
    Dilated cardiomyopathy (DCMP) is a myocardial disease associated with dilatation of one or both the ventricles, impaired myocardial contractility, decreased cardiac output, and increased ventricular filling pressures. Patients with end-stage renal disease are dependent on renal replacement therapy to survive and often manifest with a variety of pathological organ dysfunction. We present a case of DCMP and chronic kidney disease posted for emergency reduction of strangulated umbilical hernia under general plus epidural anesthesia. Read More

    Extracorporeal membrane oxygenation for cardiogenic shock due to alcoholic cardiomyopathy: a long-term follow-up of 4 cases.
    Interact Cardiovasc Thorac Surg 2017 Dec 20. Epub 2017 Dec 20.
    Intensive Care Unit, Centre Hospitalier Universitaire La Réunion, Site Félix Guyon, Saint-Denis, France.
    Even though alcoholism is a major health concern, alcoholic cardiomyopathy is a little-known pathology. The exact prevalence remains elusive (20-40% of dilated cardiomyopathy). However, it can lead to dilated cardiomyopathy, heart failure and refractory cardiogenic shock. Read More

    Response by Halliday et al to Letter Regarding Article, "Association Between Midwall Late Gadolinium Enhancement and Sudden Cardiac Death in Patients with Dilated Cardiomyopathy and Mild and Moderate Left Ventricular Systolic Dysfunction".
    Circulation 2018 Jan;137(1):101-102
    Cardiovascular Research Centre and Cardiovascular Magnetic Resonance Unit, Royal Brompton Hospital, London, UK. National Heart & Lung Institute, Imperial College, London, UK.

    Cardiac resynchronization therapy device implantation in a patient with persistent left superior vena cava without communicating innominate vein - should we proceed from the same side? - A dilemma revisited.
    Indian Pacing Electrophysiol J 2017 Dec 21. Epub 2017 Dec 21.
    Holy Family Hospital, Mumbai, India.
    Persistent left superior vena cava (PLSVC) is an uncommon congenital anomaly. We report a case of implantation of cardiac resynchronization therapy - pacemaker (CRT-P) device in a 38-year-old lady with idiopathic dilated cardiomyopathy. After left axillary vein puncture, we faced an unexpected entry of left subclavian to PLSVC draining into the coronary sinus (CS). Read More

    Evolving concepts in dilated cardiomyopathy.
    Eur J Heart Fail 2017 Dec 22. Epub 2017 Dec 22.
    Cardiovascular Department 'Ospedali Riuniti' and University of Trieste, Trieste, Italy.
    Dilated cardiomyopathy (DCM) represents a particular aetiology of systolic heart failure that frequently has a genetic background and usually affects young patients with few co-morbidities. The prognosis of DCM has improved substantially during the last decades due to more accurate aetiological characterization, the red-flag integrated approach to the disease, early diagnosis through systematic familial screening, and the concept of DCM as a dynamic disease requiring constant optimization of medical and non-pharmacological evidence-based treatments. However, some important issues in clinical management remain unresolved, including the role of cardiac magnetic resonance for diagnosis and risk categorization and the interaction between genotype and clinical phenotype, and arrhythmic risk stratification. Read More

    Autosomal Dominant Polycystic Kidney Patients May Be Predisposed to Various Cardiomyopathies.
    Kidney Int Rep 2017 Sep 6;2(5):913-923. Epub 2017 Jun 6.
    Division of Nephrology and Hypertension, Mayo Clinic College of Medicine, Rochester, Minnesota, USA.
    Introduction: Mutations in PKD1 and PKD2 cause autosomal dominant polycystic kidney disease (ADPKD). Experimental evidence suggests an important role of the polycystins in cardiac development and myocardial function. To determine whether ADPKD may predispose to the development of cardiomyopathy, we have evaluated the coexistence of diagnoses of ADPKD and primary cardiomyopathy in our patients. Read More

    Clinical predictors of outcome in patients with inflammatory dilated cardiomyopathy.
    PLoS One 2017 21;12(12):e0188491. Epub 2017 Dec 21.
    Department of Cardiology, Angiology and Intensive Care, Philipps University Marburg, Marburg, Germany.
    Objectives: The study objectives were to identify predictors of outcome in patients with inflammatory dilated cardiomyopathy (DCMi).

    Methods: From 2004 to 2008, 55 patients with biopsy-proven DCMi were identified and followed up for 58.2±19. Read More

    [Changes in the diameter and length of hypertrophic cardiomyocytes in the dilated left ventricle of cardiac surgical patients].
    Arkh Patol 2017 ;79(6):14-21
    A.N. Bakulev Research Center of Cardiovascular Surgery, Ministry of Health of Russia, Moscow, Russia.
    Aim: to investigate changes in the diameter and length of hypertrophic cardiomyocytes (CMCs) in the dilated left ventricle (LV).

    Subjects And Methods: Light microscopy, morphometry, and statistical analysis were used to investigate the status of the contractile apparatus and changes in the length, diameter of CHC and diameter of CMC nuclei, by using intraoperative dilated LV biopsy samples from 31 patients with valvular disorders and dilated cardiomyopathy. Morphological findings were compared with the clinical parameters of the patients. Read More

    Homozygous Resistance to Thyroid Hormone β: Can Combined Antithyroid Drug and Triiodothyroacetic Acid Treatment Prevent Cardiac Failure?
    J Endocr Soc 2017 Sep 8;1(9):1203-1212. Epub 2017 Aug 8.
    University of Cambridge Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge CB2 0QQ, United Kingdom.
    Resistance to thyroid hormone β (RTHβ) due to homozygous THRB defects is exceptionally rare, with only five kindreds reported worldwide. Cardiac dysfunction, which can be life-threatening, is recognized in the disorder. Here we describe the clinical, metabolic, ophthalmic, and cardiac findings in a 9-year-old boy harboring a biallelic THRB mutation (R243Q), along with biochemical, physiologic, and cardiac responses to carbimazole and triiodothyroacetic acid (TRIAC) therapy. Read More

    Production of aldosterone in cardiac tissues of healthy dogs and with dilated myocardiopathy.
    Vet World 2017 Nov 12;10(11):1329-1332. Epub 2017 Nov 12.
    Faculty of Veterinary Medicine and Animal Husbandry, Meritorious Autonomous University of Puebla, Tecamachalco Puebla, México.
    Background And Aim: Aldosterone is a hormone, belonging to the group of mineralocorticoids, mainly synthesized in the adrenal cortex, basically its function is to regulate blood pressure and sodium-potassium levels in the body; high levels of this hormone have harmful effects in the organism and mainly in the heart in chronic form. Dilated cardiomyopathy is a progressive disease of heart muscle that is characterized by ventricular chamber enlargement and contractile dysfunction, is one of the most common cardiac conditions in dogs of medium and large breeds. The aim of the study was to determine and quantify if a dog's cardiac cells possess the capacity to synthesize aldosterone, as well as, the differences that appear between a healthy heart and with dilated myocardiopathy (DMC). Read More

    Adiponectin attenuates profibrotic extracellular matrix remodeling following cardiac injury by up-regulating matrix metalloproteinase 9 expression in mice.
    Physiol Rep 2017 Dec;5(24)
    Department of Cardiology, Charité University Medicine Berlin, Campus Benjamin Franklin, Berlin, Germany
    Adiponectin (APN) is a multifunctional adipocytokine that inhibits myocardial fibrosis, dilatation, and left ventricular (LV) dysfunction after myocardial infarction (MI). Coxsackievirus B3 (CVB3) myocarditis is associated with intense extracellular matrix (ECM) remodeling which might progress to dilated cardiomyopathy. Here, we investigated in experimental CVB3 myocarditis whether APN inhibits adverse ECM remodeling following cardiac injury by affecting matrix metalloproteinase (MMP) expression. Read More

    Contractile reserve as a predictor of prognosis in patients with non-ischaemic systolic heart failure and dilated cardiomyopathy: a systematic review and meta-analysis.
    Echo Res Pract 2018 Mar 4;5(1):1-9. Epub 2017 Dec 4.
    Barts Heart Centre, St Bartholomew's Hospital, London, UK
    Objective: Patients with non-ischaemic systolic heart failure (HF) and idiopathic dilated cardiomyopathy (DCM) are a heterogenous group with varied morbidity and mortality. Prognostication in this group is challenging. We performed a systematic review and meta-analysis to examine the significance of the presence of contractile reserve as assessed via stress imaging on mortality and hospitalisation. Read More

    Extracardiac compression of the inferolateral branch of the coronary vein by the descending aorta in a patient with dilated cardiomyopathy.
    J Arrhythm 2017 Dec 11;33(6):646-648. Epub 2017 Oct 11.
    Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, 7-5-1, Kusunoki-cho, Chuo-ku, Kobe, Hyogo 650-0017, Japan.
    Extracardiac structures can cause distortion of cardiac anatomy particularly in patients presenting with a significantly dilated heart, and/or thoracic deformities. We present the case of a 69-year-old woman with dilated cardiomyopathy who underwent cardiac resynchronization therapy. Preoperative electrocardiography-gated contrast-enhanced computed tomography revealed the inferolateral wall of her significantly dilated and leftward-rotated heart was close to the descending aorta, and the descending aorta compressed the sandwiched inferolateral branch of the coronary vein. Read More

    Clinical Profile of Atrial Fibrillation in a Tertiary Hospital in Central Nepal.
    JNMA J Nepal Med Assoc 2017 Jul-Sep;56(207):335-340
    Department of Cardiology, College of Medical Sciences, Chitwan, Nepal.
    Introduction: Atrial fibrillation is a common cardiac arrhythmia in elderly causing morbidity and mortality.

    Methods: A cross-sectional descriptive study was conducted in College of Medical Sciences Teaching Hospital from August 2013 to July 2016. All in-patients diagnosed with atrial fibrillation were included. Read More

    N-Acetylcysteine Attenuates the Development of Renal Fibrosis in Transgenic Mice with Dilated Cardiomyopathy.
    Sci Rep 2017 Dec 18;7(1):17718. Epub 2017 Dec 18.
    Baker Heart and Diabetes Institute, Melbourne, Australia.
    Mechanisms underlying the renal pathology in cardiorenal syndrome (CRS) type 2 remain elusive. We hypothesised that renal glutathione deficiency is central to the development of CRS type 2. Glutathione precursor, N-acetylcysteine (NAC;40 mg/kg/day; 8 weeks) or saline were administered to transgenic mice with dilated cardiomyopathy (DCM) and wild-type (WT) controls. Read More

    MicroRNA-221/222 Family Counteracts Myocardial Fibrosis in Pressure Overload-Induced Heart Failure.
    Hypertension 2018 Feb 18;71(2):280-288. Epub 2017 Dec 18.
    From the Department of Cardiology (R.V., T.P., R.v.L., W.V., M.H., L.J.d.W., S.H., B.S.), Department of Physiology (C.M., F.A.v.N., M.v.B.), and Department of Internal Medicine (M.B.), CARIM School for Cardiovascular Diseases, Maastricht University, The Netherlands; Program of Cardiovascular Diseases, Centre for Applied Medical Research, University of Navarra, Pamplona, Spain (F.J.B., J.D., A.G.); Instituto de Investigación Sanitaria de Navarra (IdiSNA), Pamplona, Spain (F.J.B., J.D., A.G.); CIBERCV, Carlos III Institute of Health, Madrid, Spain (F.J.B., J.D., A.G.); Department of Molecular Cell Biology, Leiden University Medical Biology Center, The Netherlands (T.v.H., M.J.G.); Department of Cardiology and Cardiac Surgery, University of Navarra Clinic, Pamplona, Spain (J.D.); Netherlands Heart Institute (ICIN), Utrecht; and Department of Cardiovascular Sciences, Centre for Molecular and Vascular Biology (CMVB), KU Leuven, Belgium (S.H.).
    Pressure overload causes cardiac fibroblast activation and transdifferentiation, leading to increased interstitial fibrosis formation and subsequently myocardial stiffness, diastolic and systolic dysfunction, and eventually heart failure. A better understanding of the molecular mechanisms underlying pressure overload-induced cardiac remodeling and fibrosis will have implications for heart failure treatment strategies. The microRNA (miRNA)-221/222 family, consisting of miR-221-3p and miR-222-3p, is differentially regulated in mouse and human cardiac pathology and inversely associated with kidney and liver fibrosis. Read More

    Collagen I and III, MMP-1 and TIMP-1 immunoexpression in dilated cardiomyopathy.
    Rom J Morphol Embryol 2017 ;58(3):777-781
    Department of Pathology, University of Medicine and Pharmacy of Craiova, Romania;
    The extracellular matrix (ECM) remodeling represents the pathological substrate of dilated cardiomyopathy (DCM). In this study, we statistically analyzed the immunoexpression of collagen I and III, matrix metalloproteinase-1 (MMP-1) and its tissue inhibitor-1 (TIMP-1) in the myocardial tissue in 18 cases of DCM compared to a control group. We observed a significant increase in the immunoexpression of collagen I and III in patients with DCM and a significant reduction in the immunoexpression of MMP-1 compared with the control group. Read More

    Barth Syndrome: Different Approaches to Diagnosis.
    J Pediatr 2017 Dec 15. Epub 2017 Dec 15.
    Division of Functional Genomics and Systems Medicine, Research Center for Genomic Medicine, Saitama Medical University, Saitama, Japan; Division of Translational Research, Research Center for Genomic Medicine, Saitama Medical University, Saitama, Japan. Electronic address:
    The diagnosis of Barth syndrome is challenging owing to the wide phenotypic spectrum with allelic heterogeneity. Here we report 3 cases of Barth syndrome with phenotypic and allelic heterogeneity that were diagnosed by different approaches, including whole exome sequencing and final confirmation by reverse-transcription polymease chain reaction. Read More

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