23,318 results match your criteria Cardiomyopathy Dilated


Activation of sarcolipin expression and altered calcium cycling in cardiomyopathy.

Biochem Biophys Rep 2020 Jul 18;22:100767. Epub 2020 May 18.

Sorbonne Université, INSERM UMRS974, Paris, France.

Cardiomyopathy caused by A-type lamins gene () mutations ( cardiomyopathy) is associated with dysfunction of the heart, often leading to heart failure. cardiomyopathy is highly penetrant with bad prognosis with no specific therapy available. Searching for alternative ways to halt the progression of cardiomyopathy, we studied the role of calcium homeostasis in the evolution of this disease. Read More

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http://dx.doi.org/10.1016/j.bbrep.2020.100767DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7261707PMC

Cardiac magnetic resonance in cocaine-induced myocardial damage: cocaine, heart, and magnetic resonance.

Heart Fail Rev 2020 Jun 2. Epub 2020 Jun 2.

Fondazione Toscana Gabriele Monasterio, Via Giuseppe Moruzzi, 156124, Pisa, Italy.

The use of cocaine constitutes a major health problem. Cocaine use is associated with acute and chronic complications that might involve any system, the most common being the cardiovascular system. The precise incidence of cocaine-induced cardiomyopathy remains mysterious and probably underreported. Read More

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http://dx.doi.org/10.1007/s10741-020-09983-3DOI Listing

Core functional nodes and sex-specific pathways in human ischaemic and dilated cardiomyopathy.

Nat Commun 2020 Jun 2;11(1):2843. Epub 2020 Jun 2.

Precision Cardiovascular Laboratory, The University of Sydney, Sydney, NSW, Australia.

Poor access to human left ventricular myocardium is a significant limitation in the study of heart failure (HF). Here, we utilise a carefully procured large human heart biobank of cryopreserved left ventricular myocardium to obtain direct molecular insights into ischaemic cardiomyopathy (ICM) and dilated cardiomyopathy (DCM), the most common causes of HF worldwide. We perform unbiased, deep proteomic and metabolomic analyses of 51 left ventricular (LV) samples from 44 cryopreserved human ICM and DCM hearts, compared to age-, gender-, and BMI-matched, histopathologically normal, donor controls. Read More

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http://dx.doi.org/10.1038/s41467-020-16584-zDOI Listing

An unusual case of tropical pyomyositis: cryptococcal pyomyositis.

Trop Doct 2020 Jun 2:49475520927633. Epub 2020 Jun 2.

Clinical Pharmacist, Department of Infectious Diseases, Apollo Hospitals, Hyderabad, Telangana, India.

The more common manifestations of cryptococcal infections are restricted to the central nervous system and lungs. A young man, suffering from idiopathic dilated cardiomyopathy with a left ventricular ejection fraction of 20%, presented with subacute, painful tender swelling in both legs initially attributed to congestive cardiac failure. No response to diuretics was achieved. Read More

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http://dx.doi.org/10.1177/0049475520927633DOI Listing

BET bromodomain inhibition attenuates cardiac phenotype in myocyte-specific Lamin A/C-deficient mice.

J Clin Invest 2020 Jun 2. Epub 2020 Jun 2.

Center for Cardiovascular Genetics, Institute of Molecular Medicine and Dep, University of Texas Health Science Center at Houston, Houston, United States of America.

Mutation in the LMNA gene, encoding Lamin A/C, cause a diverse group of diseases called laminopathies. Cardiac involvement is the major cause of death and manifests as dilated cardiomyopathy (DCM), heart failure, arrhythmias, and sudden death. There is no specific therapy for LMNA-associated cardiomyopathy. Read More

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http://dx.doi.org/10.1172/JCI135922DOI Listing

Cardiac Resynchronization Therapy in Pediatrics.

J Innov Card Rhythm Manag 2018 Aug 15;9(8):3256-3264. Epub 2018 Aug 15.

Division of Cardiology, Children's Hospital Los Angeles, Los Angeles, CA, USA.

Cardiac resynchronization therapy (CRT) has proven to be a powerful and effective tool in the treatment of adults with severe dilated or ischemic cardiomyopathy. A substantial portion of the adult heart failure population has severely depressed systolic function, heart failure symptoms, QRS prolongation, and left bundle branch block. Indications for CRT in adults are commonly focused on these characteristics. Read More

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http://dx.doi.org/10.19102/icrm.2018.090804DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7252792PMC

Expanding the clinical and genetic spectrum of ALPK3 variants: Phenotypes identified in pediatric cardiomyopathy patients and adults with heterozygous variants.

Am Heart J 2020 Apr 21;225:108-119. Epub 2020 Apr 21.

Department of Clinical Genetics, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.

Introduction: Biallelic damaging variants in ALPK3, encoding alpha-protein kinase 3, cause pediatric-onset cardiomyopathy with manifestations that are incompletely defined.

Methods And Results: We analyzed clinical manifestations of damaging biallelic ALPK3 variants in 19 pediatric patients, including nine previously published cases. Among these, 11 loss-of-function (LoF) variants, seven compound LoF and deleterious missense variants, and one homozygous deleterious missense variant were identified. Read More

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http://dx.doi.org/10.1016/j.ahj.2020.03.023DOI Listing

Characterization of interstitial diffuse fibrosis patterns using texture analysis of myocardial native T1 mapping.

PLoS One 2020 1;15(6):e0233694. Epub 2020 Jun 1.

Cardiovascular Division, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, United States of America.

Background: The pattern of myocardial fibrosis differs significantly between different cardiomyopathies. Fibrosis in hypertrophic cardiomyopathy (HCM) is characteristically as patchy and regional but in dilated cardiomyopathy (DCM) as diffuse and global. We sought to investigate if texture analyses on myocardial native T1 mapping can differentiate between fibrosis patterns in patients with HCM and DCM. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0233694PLOS

Post-transplant survival in ACHD patients as compared to dilated and ischemic cardiomyopathy patients; an analysis of the thoracic ISHLT registry.

Clin Transplant 2020 Jun 1. Epub 2020 Jun 1.

Peter Munk Cardiac Centre, Toronto General Hospital, Toronto, ON, Canada.

Previous studies have shown that adult congenital heart disease (ACHD) is associated with high early post-transplant mortality but improved long-term survival in comparison to the overall heart transplant population. We aimed to evaluate survival outcomes of ACHD in adult transplant recipient patients as specifically compared to ischemic (ICM) and dilated cardiomyopathy (DCM) groups. Adult heart transplant recipients between 2004 and 2014 were identified from the ISHLT registry. Read More

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http://dx.doi.org/10.1111/ctr.13985DOI Listing

A Doxorubicin-Induced Murine Model of Dilated Cardiomyopathy In Vivo.

J Vis Exp 2020 May 16(159). Epub 2020 May 16.

Department of Cardiology, Nanjing Drum Tower Hospital, Clinical College of Nanjing Medical University;

Dilated cardiomyopathy (DCM) refers to a spectrum of heterogeneous myocardial disorders characterized by ventricular dilation and depressed cardiac performance in the absence of hypertension, valvular, congenital, or ischemic heart diseases, and which may be related to infection, autoimmune or metabolic abnormalities, or family inheritance. It can progress into congestive heart failure with a poor prognosis. Doxorubicin (Dox) is widely employed as a chemotherapeutic drug, but its use is limited because it causes DCM-like changes of the myocardium. Read More

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http://dx.doi.org/10.3791/61158DOI Listing

Catheter Ablation of Scar-mediated Ventricular Tachycardia: Are Substrate-based Approaches Replacing Mapping?

Authors:
Richard H Hongo

J Innov Card Rhythm Manag 2019 Jun 15;10(6):3707-3715. Epub 2019 Jun 15.

Atrial Fibrillation and Complex Arrhythmia Center, California Pacific Medical Center, San Francisco, CA, USA.

Scar-mediated ventricular tachycardia (VT) is a recognized cause of morbidity and mortality in patients with ischemic cardiomyopathy and other cardiomyopathies such as nonischemic cardiomyopathy, arrhythmogenic right ventricular cardiomyopathy, and cardiac sarcoidosis. Implantable cardioverter-defibrillator (ICD) therapy improves survival but does not prevent the onset of recurrent VT or associated morbidity from ICD shocks. While randomized controlled trials have demonstrated advantages of scar-mediated VT ablation in comparison with antiarrhythmic drugs, procedural success has remained overall modest at between 50% and 70%. Read More

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http://dx.doi.org/10.19102/icrm.2019.100603DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7252775PMC

Advances in Stem Cell Modeling of Dystrophin-Associated Disease: Implications for the Wider World of Dilated Cardiomyopathy.

Front Physiol 2020 12;11:368. Epub 2020 May 12.

Division of Physiology, Department of Experimental and Clinical Medicine, Università degli Studi di Firenze, Florence, Italy.

Familial dilated cardiomyopathy (DCM) is mostly caused by mutations in genes encoding cytoskeletal and sarcomeric proteins. In the pediatric population, DCM is the predominant type of primitive myocardial disease. A severe form of DCM is associated with mutations in the gene encoding dystrophin, which are the cause of Duchenne Muscular Dystrophy (DMD). Read More

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http://dx.doi.org/10.3389/fphys.2020.00368DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7235370PMC

Longitudinal Changes in Cardiac Structure and Function in Severe Obesity: 11-Year Follow-Up in the Utah Obesity Study.

J Am Heart Assoc 2020 Jun 1:e014542. Epub 2020 Jun 1.

Division of Epidemiology University of Utah School of Medicine Salt Lake City UT.

Background Progressive cardiac remodeling and worsening myocardial function over time have been proposed as potential mediators of heart failure in obesity. Methods and Results We serially assessed cardiac structure and function in 254 subjects participating in a longitudinal study of obesity. Demographic, clinical, laboratory, and echocardiographic features were determined at baseline and 2-, 6-, and 11-year follow-up. Read More

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http://dx.doi.org/10.1161/JAHA.119.014542DOI Listing

Ruptured cerebral mycotic aneurysm in a left ventricular assist device patient with bacteremia.

Int J Artif Organs 2020 May 30:391398820925493. Epub 2020 May 30.

Division of Cardiac Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.

A 50-year-old male with a history of nonischemic dilated cardiomyopathy presented in cardiogenic shock and ultimately underwent durable left ventricular assist device implantation. He recovered well initially but developed persistent bacteremia. His indwelling pacemaker leads were extracted due to evidence of vegetation. Read More

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http://dx.doi.org/10.1177/0391398820925493DOI Listing

BAG3 Pro209 mutants associated with myopathy and neuropathy relocate chaperones of the CASA-complex to aggresomes.

Sci Rep 2020 May 29;10(1):8755. Epub 2020 May 29.

Peripheral Neuropathy Research Group, Department of Biomedical Sciences, Institute Born Bunge, University of Antwerp, Antwerp, Belgium.

Three missense mutations targeting the same proline 209 (Pro209) codon in the co-chaperone Bcl2-associated athanogene 3 (BAG3) have been reported to cause distal myopathy, dilated cardiomyopathy or Charcot-Marie-Tooth type 2 neuropathy. Yet, it is unclear whether distinct molecular mechanisms underlie the variable clinical spectrum of the rare patients carrying these three heterozygous Pro209 mutations in BAG3. Here, we studied all three variants and compared them to the BAG3_Glu455Lys mutant, which causes dilated cardiomyopathy. Read More

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http://dx.doi.org/10.1038/s41598-020-65664-zDOI Listing

Silencing of CCR4-NOT complex subunits affect heart structure and function.

Dis Model Mech 2020 May 29. Epub 2020 May 29.

Development Aging and Regeneration Program, Sanford Burnham Prebys Medical Discovery Institute, 10901 N Torrey Pines Rd, La Jolla, CA 92037, USA

Genome wide association studies (GWAS) have identified variants that associate with QT-interval length. Three of the strongest associating variants (SNPs) are located in the putative promotor region of , a gene encoding the central subunit of CCR4-NOT, a multi-functional, conserved complex regulating gene expression and mRNA stability and turnover. We isolated the minimum fragment of the promoter containing all three variants from individuals homozygous for the QT-risk alleles and demonstrated that the haplotype associating with longer QT-interval caused reduced reporter expression in a cardiac cell line, suggesting that reduced expression may contribute to abnormal QT-intervals. Read More

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http://dx.doi.org/10.1242/dmm.044727DOI Listing

High expression levels and localization of Sox5 in dilated cardiomyopathy.

Mol Med Rep 2020 May 22. Epub 2020 May 22.

Department of Thoracic and Cardiovascular Surgery, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu 210006, P.R. China.

Dilated cardiomyopathy (DCM) is a disease that can lead to heart expansion and severe heart failure, but the specific pathogenesis remains unclear. Sox5 is a member of the Sox family with a key role in cardiac function. However, the role of Sox5 in DCM remains unclear. Read More

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http://dx.doi.org/10.3892/mmr.2020.11180DOI Listing

A Population-Based Registry of Patients With Inherited Cardiac Conditions and Resuscitated Cardiac Arrest.

J Am Coll Cardiol 2020 Jun;75(21):2698-2707

Greenlane Paediatric and Congenital Cardiac Services, Starship Children's Hospital, Auckland, New Zealand; Cardiac Inherited Disease Group, Auckland, New Zealand; Department of Paediatrics Child and Youth Health, University of Auckland, Auckland, New Zealand. Electronic address:

Background: The relative proportion of each cardiac inherited disease (CID) causing resuscitated sudden cardiac arrest (RSCA) on a population basis is unknown.

Objectives: This study describes the profile of patients with CIDs presenting with RSCA; their data were collected by the national Cardiac Inherited Diseases Registry New Zealand (CIDRNZ).

Methods: Data were collated from CIDRNZ probands presenting with RSCA (2002 to 2018). Read More

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http://dx.doi.org/10.1016/j.jacc.2020.04.004DOI Listing

Cost-Effectiveness of Immediate Ventricular Assist Device Implantation in Children with Inotrope-Dependent Heart Failure.

J Heart Lung Transplant 2020 Apr 30;39(4S):S87. Epub 2020 Mar 30.

Health Management and Policy, University of Michigan School of Public Health, Ann Arbor, MI.

Purpose: Ventricular assist devices (VADs) have improved wait list survival in children with end-stage heart failure. However, questions remain about the optimal timing of VAD implantation. In this cost-effectiveness analysis, we compared immediate intracorporeal continuous VAD implantation to a watchful waiting approach using continuous inotropic therapy. Read More

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http://dx.doi.org/10.1016/j.healun.2020.01.1318DOI Listing

Intracorporeal VAD Outcomes in the ACTION Quality Improvement Network.

J Heart Lung Transplant 2020 Apr 30;39(4S):S84. Epub 2020 Mar 30.

Pediatric Cardiology, Cincinnati Children's Hospital, Cincinnati, OH.

Purpose: The initial project of ACTION (Advanced Cardiac Therapies Improving Outcomes Network) is focused on improving stroke rates in patients implanted with a ventricular assist devices (VAD) in participating centers. The initial interventions targeted improving communication, anticoagulation, and blood pressure management. We sought to describe the characteristics and outcomes of patients implanted with intracorporeal, continuous flow VADs (cfVAD). Read More

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http://dx.doi.org/10.1016/j.healun.2020.01.1312DOI Listing

Genetic Profiling of Combined Post-Capillary and Pre-Capillary Pulmonary Hypertension in Left Heart Diseases.

J Heart Lung Transplant 2020 Apr 30;39(4S):S512. Epub 2020 Mar 30.

Department of Cardiology, CUB Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium.

Purpose: Pulmonary hypertension (PH) in left heart diseases (LHD) has been redefined as isolated post-capillary PH (IpcPH) and combined post-capillary and pre-capillary PH (CpcPH). CpcPH's pathophysiology is not well understood. Predisposing constitutional factors may play a role in CpcPH development, as suggested by the variability in the adaptation of the pulmonary circulation to the elevation of pulmonary artery wedge pressure (PAWP). Read More

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http://dx.doi.org/10.1016/j.healun.2020.01.130DOI Listing

Safety and Feasibility of Home INR Monitoring for Outpatient Ventricular Assist Device Support in Children.

J Heart Lung Transplant 2020 Apr 30;39(4S):S495. Epub 2020 Mar 30.

Cardiology, Boston Children's Hospital, Boston, MA.

Purpose: The use of intracorporeal continuous flow (CF) ventricular assist devices- namely the Heartware™ HVAD™- has expanded dramatically in the children, with many being discharged home. We sought to evaluate the feasibility and outcomes of children discharged home with point of care (POC) INR monitors for their warfarin anticoagulation management.

Methods: This is a retrospective single center review of all pediatric patients, aged ≤19 years at time of implantation, who were discharged home for longer than 1 week. Read More

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http://dx.doi.org/10.1016/j.healun.2020.01.079DOI Listing

Adverse Events Following Cardiac Catheterization among Infants, Children, and Young Adults on Ventricular Assist Device Support.

J Heart Lung Transplant 2020 Apr 30;39(4S):S465-S466. Epub 2020 Mar 30.

Pediatric Cardiology, Stanford University, Lucile Packard Children's Hospital, Palo Alto, CA.

Purpose: Children on ventricular assist device (VAD) support often present unique challenges, such as small size, univentricular or biventricular congenital heart disease (1V- or 2V-CHD), and need for biventricular (BiVAD) support. While cardiac catheterization (cath) can provide valuable information in the management of pediatric patients on VAD support, it is an invasive procedure with inherent risks. We sought to evaluate the safety of cath in this population. Read More

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http://dx.doi.org/10.1016/j.healun.2020.01.319DOI Listing

Natural History of Hemodynamic Maturation Post Heart Transplantation in the Absence of Rejection.

J Heart Lung Transplant 2020 Apr 30;39(4S):S463. Epub 2020 Mar 30.

Cardiovascular and Thoracic Surgery, Medical College of Wisconsin, Milwaukee, WI.

Purpose: Routine catheterization is a part of transplant surveillance, however there is extremely limited data on evolution of hemodynamic parameters post heart transplant. Knowledge of these normative data will be useful in interpretation of individual catheterization results, assessment of graft performance and identification of risk factors.

Methods: Prospectively collected transplant and hemodynamic data for patients enrolled in the Quantitative Detection of Circulating Donor-Specific DNA in Organ Transplant Recipients (DTRT Study) was secondarily analyzed. Read More

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http://dx.doi.org/10.1016/j.healun.2020.01.312DOI Listing

Heightened Immune Response and Increased Risk of Infections in Pediatric Fontan Patients after Heart Transplantation.

J Heart Lung Transplant 2020 Apr 30;39(4S):S452-S453. Epub 2020 Mar 30.

Stanford University Lucile Packard Children's Hospital, Palo Alto, CA.

Purpose: Infectious complications are a major cause of morbidity & mortality after heart transplantation (HT). Patients who have undergone Fontan palliation may have a higher susceptibility to post HT infections given thymectomy in infancy and known depletions of T-cell subsets.

Methods: This was a single-center, retrospective cohort analysis of pediatric patients undergoing HT for dilated cardiomyopathy (DCM) or failing Fontan physiology, who underwent post HT induction with anti-thymoglobulin (ATG). Read More

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http://dx.doi.org/10.1016/j.healun.2020.01.283DOI Listing

High Dosage of Carvedilol is Effective to Induce Remodeling and Improve of Survival in Children with Dilated Cardiomyopathy.

J Heart Lung Transplant 2020 Apr 30;39(4S):S451. Epub 2020 Mar 30.

Bambino Gesù Hospital, Rome, Italy.

Purpose: We aim to evaluate clinical outcomes, echocardiographic changes, heart rate (HR) modifications and side effects in children with dilated cardiomyopathy (DCM) and chronic heart failure (HF) treated by high dosage of carvedilol.

Methods: We prospectively enrolled pediatric patients with DCM and ventricular dysfunction (EF <45%) referred to our institute. All enrolled patients were treated with high dosage of carvedilol coupled to heart failure therapy (ace inhibitors; diuretics, aldosterone blockade) in order to achieve a reduction of heart rate > 20% from baseline. Read More

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http://dx.doi.org/10.1016/j.healun.2020.01.278DOI Listing

Outcomes in Patients with Smaller Left Ventricular End Diastolic Diameter Following HeartMate 3 (HM3) Left Ventricular Assist Device (LVAD) Implantation.

J Heart Lung Transplant 2020 Apr 30;39(4S):S434. Epub 2020 Mar 30.

Advanced Heart Failure, Medstar Washington Hospital Center, Washington, DC.

Purpose: Outcomes in patients with small left ventricular end diastolic diameter (LVEDD) following HM3 LVAD implantation have not been well characterized. We sought to compare the clinical outcomes of patients with small LVEDD to those with dilated left ventricles.

Methods: Patients who received a HeartMate 3 LVAD at our institution between October 1, 2015 and June 30, 2019 were analyzed. Read More

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http://dx.doi.org/10.1016/j.healun.2020.01.233DOI Listing

Cerebrovascular Events in Pediatric Population on Intracorporeal Continuous-Flow Ventricular Assist Devices: Single Center Experience.

J Heart Lung Transplant 2020 Apr 30;39(4S):S409. Epub 2020 Mar 30.

Cardiac Surgery, Ankara City Hospital, Ankara, Turkey.

Purpose: Continuous flow intracorporeal left ventricular assist devices(CF-LVAD) are used more frequently in pediatric population. One of the major complications of CF-LVAD includes cerebrovascular events(CVE) and little is known about this complication in pediatric patients.

Methods: We performed a retrospective, single center review of 21 patients younger than 19 years of age who underwent CF-LVAD implantation between June 2014 and September 2018. Read More

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http://dx.doi.org/10.1016/j.healun.2020.01.167DOI Listing

Clinical Utility of Using Next Generation Sequencing in Life Threatening Ventricular Arrhythmia.

J Heart Lung Transplant 2020 Apr 30;39(4S):S360. Epub 2020 Mar 30.

National Laboratory Astana, Center for Life Sciences, Nazarbayev University, Nur-Sultan, Kazakhstan.

Purpose: Ventricular fibrillation (VF) and ventricular tachycardia (VT) are major causes of sudden cardiac death. In some cases clinical investigations fail to identify the underlying cause and the event is classified as idiopathic (iVT). Recent achievements in molecular genetics has unveiled the complex molecular basis of many cardiac conditions, paving the way for routine use of gene testing in clinical practice. Read More

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http://dx.doi.org/10.1016/j.healun.2020.01.432DOI Listing

Dysregulation of H11 Kinase in the Failing Human Left Ventricular Myocardium.

J Heart Lung Transplant 2020 Apr 30;39(4S):S357. Epub 2020 Mar 30.

Medicine, Henry Ford Health System, Detroit, MI.

Purpose: Mitochondrial dysfunction and ongoing cardiomyocyte loss from apoptosis contribute to the progressive LV dysfunction characteristic of the heart failure (HF) state. H11 kinase (H11K) is a 22-kD serine/threonine kinase protein abundantly expressed in the heart. Dysregulation of H11K occurs in HF but its potential contribution to the progression of HF is not fully understood. Read More

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http://dx.doi.org/10.1016/j.healun.2020.01.425DOI Listing

Real World Experience with the HeartMate 3 (HM3) Left Ventricular Assist Device (LVAD): Analysis of the First 125 Consecutive Patients at a Single Institution.

J Heart Lung Transplant 2020 Apr 30;39(4S):S338. Epub 2020 Mar 30.

Advanced Heart Failure, Medstar Washington Hospital Center, Washington, DC.

Purpose: Excellent outcomes following HM3 LVAD implantation have been reported in the setting of a large multicenter randomized controlled trial. Real world experience reports with this device are still limited. We sought to review our experience with this fully magnetically levitated LVAD. Read More

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http://dx.doi.org/10.1016/j.healun.2020.01.373DOI Listing

Patient Outcomes after Heart Transplantation in Sweden between 1988 and 2017: Continuous Improvement in Survival.

J Heart Lung Transplant 2020 Apr 30;39(4S):S284. Epub 2020 Mar 30.

Transplant Institute, Sahlgrenska University Hospital, Gothenburg, Sweden.

Purpose: To investigate the survival of heart transplant (HTx) recipients during different time periods in Sweden. We hypothesized that the survival for HTx recipients has improved following advancements in the management of these patients.

Methods: Data was obtained through the database of the organ exchange organization Scandiatransplant. Read More

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http://dx.doi.org/10.1016/j.healun.2020.01.626DOI Listing

Heart Transplant Outcomes for Patients with Myocarditis.

J Heart Lung Transplant 2020 Apr 30;39(4S):S261. Epub 2020 Mar 30.

Cardiology, Keck Medicine of USC, Los Angeles, CA.

Purpose: Myocarditis is a known etiology of both acute fulminant heart failure and chronic dilated cardiomyopathy requiring heart transplantation. We sought to evaluate the long-term post-transplant outcomes of pts with myocarditis.

Methods: We evaluated the UNOS registry for all heart transplant (HT) recipients from 1987 to 2019. Read More

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http://dx.doi.org/10.1016/j.healun.2020.01.568DOI Listing

The Predictive Scoring Systems for Outcomes of Heart Transplantation in Patients with Pre-Existing Liver Cirrhosis.

J Heart Lung Transplant 2020 Apr 30;39(4S):S257-S258. Epub 2020 Mar 30.

Severance Cardiovascular Hospital, Yonsei University College of Medicine, Seoul, Korea, Republic of.

Purpose: There are few data assessing factors and clinical outcomes in patients with liver cirrhosis for heart transplantation. The aim of this study was to compare the Model for End-Stage Liver Disease (MELD) score, the MELD-XI score and Child-Turcotte-Pugh (CTP) score risk prediction in cirrhotic patients undergoing heart transplantation.

Methods: Between 1994 and 2018, forty-nine consecutive patients (19 men and 30 women, median age 46 years, range 12-68 years) had liver cirrhosis, among 170 patients underwent heart transplantations in our institution. Read More

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http://dx.doi.org/10.1016/j.healun.2020.01.559DOI Listing

Normothermic Ex-Vivo Perfusion for Donor Heart Preservation in Transplantation of Patients Bridged with Ventricular Assist Devices.

J Heart Lung Transplant 2020 Apr 30;39(4S):S245. Epub 2020 Mar 30.

Hannover Medical School, Hannover, Germany.

Purpose: Recently, it has been shown that survival after heart transplantation is impaired in patients bridged with left ventricular assist devices (LVAD), mostly due to increased rates of primary graft dysfunction (PGD). Ex vivo perfusion (EVP) is a graft preservation technique non-inferior to standard cold storage (CS). It allows to maintain the heart in a beating and perfused status during challenging surgical dissection in LVAD patients undergoing heart transplantation, and to reduce ischemic time potentially lowering the risk of PGD. Read More

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http://dx.doi.org/10.1016/j.healun.2020.01.926DOI Listing

HeartMate 3 as Total Artificial Heart for the Treatment of Biventricular Heart Failure as Bridge to Transplantation.

J Heart Lung Transplant 2020 Apr 30;39(4S):S24. Epub 2020 Mar 30.

Cardiac, Thoracic, Transplantation and Vascular Surgery, Hannover Medical School, Hannover, Germany.

Purpose: Despite maximal medican and surgical therapy, the outcomes of severe biventricular failure remain poor with mortality rates of up to 100%. The only definite therapy option for this disease is the total replacement of the heart - either by cardiac transplantation or by total artificial heart (TAH) implantation. Due to the lack of donor organs, mechanical assist devices are the most relevant option for these patients. Read More

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http://dx.doi.org/10.1016/j.healun.2020.01.1160DOI Listing

Outcomes on the Waiting List for Candidates Receiving an Angiotensin Receptor-Neprilysin Inhibitor at Listing.

J Heart Lung Transplant 2020 Apr 30;39(4S):S239. Epub 2020 Mar 30.

Agence de la Biomedecine, Saint-Denis la Plaine, France.

Purpose: The angiotensin receptor-neprilysin inhibitor, sacubitril-valsartan (SV), is indicated in patients with heart failure with reduced ejection fraction. The use of SV reduced the risk of death and of hospitalization for heart failure as compared to enalapril therapy in outpatients with NYHA class II-III symptoms. This study aimed to assess the outcomes of heart transplant candidates receiving SV at listing. Read More

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http://dx.doi.org/10.1016/j.healun.2020.01.910DOI Listing

Papillary Muscle Viability Correlates with Changes of Functional Mitral Regurgitation in Patients with Non-Ischemic Dilated Cardiomyopathy.

J Heart Lung Transplant 2020 Apr 30;39(4S):S236. Epub 2020 Mar 30.

Advanced Heart Failure and Transplantation Center, UMC Ljubljana, Ljubljana, Slovenia.

Purpose: Functional mitral regurgitation (FMR) in non-ischemic cardiomyopathy (NICM) may be partly related to the dysfunction of subvalvular apparatus. Thus, we sought to investigate the correlation between papillary muscle viability and FMR changes in NICM.

Methods: Of 35 patients with NICM (LVEF<40%, NHYA III) undergoing repeated CD34 cell transplantation we enrolled 30 patients (86%) who presented with ≥1+ grade FMR. Read More

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http://dx.doi.org/10.1016/j.healun.2020.01.900DOI Listing

Prevalence of Cognitive Impairment in Heart Transplant Waiting-List Patients in a Developing Country.

J Heart Lung Transplant 2020 Apr 30;39(4S):S236-S237. Epub 2020 Mar 30.

Transplante Cardiaco, INCOR Instituto do Coração do Hospital das Clínicas da FMUSP, São Paulo, Brazil.

Purpose: Cognitive impairment and mood deviation often occurs in patients with heart failure. Frailty and sarcopenia have been widely studied in patients with heart disease, but cognitive frailty has been little explored. High complexity of patients referred for heart transplantation connected with socioeconomic characteristics in a developing country underlines the importance to investigate cognitive and mood conditions in this population. Read More

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http://dx.doi.org/10.1016/j.healun.2020.01.902DOI Listing

Right Ventricular Function Correlates with Local Mechanical Dyssynchrony of Interventricular Septum in Patients with Non-Ischemic Dilated Cardiomyopathy.

J Heart Lung Transplant 2020 Apr 30;39(4S):S235-S236. Epub 2020 Mar 30.

Advanced Heart Failure and Transplantation Center, UMC Ljubljana, Ljubljana, Slovenia.

Purpose: The underlying mechanisms of right ventricular (RV) dysfunction in patients with non-ischemic dilated cardiomyopathy (NICM) remain poorly defined. We evaluated a potential correlation between local mechanical dyssynhcrony of interventricular septum (IVS) and RV function in these patients.

Methods: We analyzed electromechanical data of 30 NICM patients with NYHA class III, and left ventricular ejection fraction (LVEF) <40% undergoing CD34 cell therapy. Read More

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http://dx.doi.org/10.1016/j.healun.2020.01.899DOI Listing

Can Genetic Profile of Patients Undergoing Heart Transplantation Alter Clinical Decisions?

J Heart Lung Transplant 2020 Apr 30;39(4S):S232-S233. Epub 2020 Mar 30.

Molecular Immunopathology and Histocombatibility, Onassis Cardiac Surgery Center, Athens, Greece.

Purpose: Although a significant proportion of cardiomyopathies are determined by genetic factors, the genetic testing of these patients has not been introduced routinely into clinical practice. The aim of this study is the genotyping of patients with advanced cardiomyopathy who have been bridged for heart transplantation or have been already transplanted, in order to evaluate the usefulness of genetic testing in the early diagnosis of the disease, and in the clinical management of these patients and their relatives.

Methods: Fifteen heart transplanted patients and 5 patients bridged for heart transplantation due to familial dilated, hypertrophic or restrictive cardiomyopathy were genotyped with next generation sequencing, using Illumina's Trusight Cardio sequencing panel, covering 174 clinically relevant genes to cardiac diseases. Read More

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http://dx.doi.org/10.1016/j.healun.2020.01.892DOI Listing

Heart Transplant Outcomes in Patients with Alcoholic Cardiomyopathy.

J Heart Lung Transplant 2020 Apr 30;39(4S):S228. Epub 2020 Mar 30.

Div of Cardiovascular Medicine, Keck School of Medicine of USC, Los Angeles, CA.

Purpose: We sought to better characterize differences in transplant outcomes between patients with alcoholic cardiomyopathy and those with other forms of cardiomyopathy in a national cohort.

Methods: 63,142 OHT recipients were identified from UNOS (1987-2019) of which 224 had alcoholic cardiomyopathy as indication for HT. Multivariate Cox proportional hazard regression analysis was adjusted for age, sex, DM2, ethnicity, ischemic time, dialysis, life support, waitlist time and HLA mismatch. Read More

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http://dx.doi.org/10.1016/j.healun.2020.01.879DOI Listing

Preliminary Data on the Clinical Use of Infant Jarvik 2015 in Children with Dilated Cardiomyopahty; Recovery Will Be the New Therapeutic Goal?

J Heart Lung Transplant 2020 Apr 30;39(4S):S221. Epub 2020 Mar 30.

Bambino Gesù Pediatric Hospital, Rome, Italy.

Purpose: Continuous flow and intra-corporeal ventricular assist devices (VAD) in children has becoming attractive for their potential benefit in pediatric population. CF VAD for children less than 20 kg are still challenging population. We reported the effect of CF VAD in small children with dilated cardiomyopathy refractory to conventional pharmacological treatment. Read More

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http://dx.doi.org/10.1016/j.healun.2020.01.861DOI Listing

Single-Cell RNA-seq of Human Cardiomyocytes Revealed DNA Damage Response as a Novel Predictor for Therapeutic Prognosis in Heart Failure Patients with Dilated Cardiomyopathy.

J Heart Lung Transplant 2020 Apr 30;39(4S):S22-S23. Epub 2020 Mar 30.

Department of Cardiovascular Medicine, The University of Tokyo, Tokyo, Japan.

Purpose: Patients with dilated cardiomyopathy (DCM) who achieved left ventricular reverse remodeling (LVRR) have a favorable prognosis, but it is still difficult to precisely predict LVRR in the clinical setting.

Methods: We conducted single-cell RNA-seq (scRNA-seq) analysis of cardiomyocytes from both normal subjects and patients with DCM (n=10). We also obtained heart tissue specimens from patients with DCM (n=58) who underwent endomyocardial biopsy before optimal medical therapy and conducted immunofluorescence staining of DNA damage markers including poly(ADP-ribose) (PAR) and γH2A. Read More

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http://dx.doi.org/10.1016/j.healun.2020.01.1155DOI Listing

First in Man Anatomical Fitting Study of the BiVACOR Total Artificial Heart.

J Heart Lung Transplant 2020 Apr 30;39(4S):S189. Epub 2020 Mar 30.

Cardiothoracic Surgery, St Vincent's Hospital (Sydney), Darlinghurst, Australia.

Purpose: BiVACOR is a new and novel total artificial heart utilising a single centrifugal magnetically levitated motor featuring a pulsatile flow. The device has been successfully tested in cattle with encouraging 90-day results. We sought to undertake the first-in-man fitting of the device. Read More

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http://dx.doi.org/10.1016/j.healun.2020.01.779DOI Listing

You Can't Find What You Aren't Looking For: Over Half of Heart Transplant Patients Have Moderate or Strong Likelihood of Genetic Disease.

J Heart Lung Transplant 2020 Apr 30;39(4S):S166. Epub 2020 Mar 30.

Stanford Division of Cardiovascular Medicine, Stanford, CA.

Purpose: Approximately half of patients undergoing heart transplant (HTX) have a primary cardiomyopathy. There is growing evidence for a genetic basis in many primary cardiomyopathies, with HFSA guidelines recommending genetics evaluations for many of these. We sought to assess the frequency of genetic disease in a single HTX center. Read More

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http://dx.doi.org/10.1016/j.healun.2020.01.1123DOI Listing

Left Ventricular Strain and Progression of Hypertrophy in Danon Disease Cardiomyopathy: Insights from a Global Registry.

J Heart Lung Transplant 2020 Apr 30;39(4S):S154. Epub 2020 Mar 30.

Cardiovascular Disease, UC San Diego Health System, San Diego, CA.

Purpose: Danon Disease (DD) is a rare X-linked disorder due to mutations in the Lysosomal Associated Membrane Protein 2 (LAMP-2) gene. Patients present with cardiac manifestations of hypertrophic cardiomyopathy (HCM) and dilated cardiomyopathy (DCM). The goal of this study is to characterize the longitudinal progression of hypertrophic phenotypes and descriptions of left ventricular strain in DD. Read More

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http://dx.doi.org/10.1016/j.healun.2020.01.1093DOI Listing

Outcomes of Left Ventricular Assist Device for Patients with Hypertrophic Cardiomyopathy.

J Heart Lung Transplant 2020 Apr 30;39(4S):S153. Epub 2020 Mar 30.

Cardiovascular Surgery, Osaka University Graduate School of Medicine, Suita City, Osaka, Japan.

Purpose: The treatment of end stage hypertrophic cardiomyopathy (HCM) is sometimes complicated because some cases of HCM are not suitable for LVAD. Scarce data exist on outcomes of continuous-flow (CF) LVAD support in these challenging patient cohorts. We evaluated the clinical outcomes of LVAD therapy for patients with HCM. Read More

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http://dx.doi.org/10.1016/j.healun.2020.01.1091DOI Listing

RNA Sequencing Reveals Differentially Expressed Genes in Left Ventricular Biopsies from Ischemic and Dilated Cardiomyopathy Patients.

J Heart Lung Transplant 2020 Apr 30;39(4S):S152. Epub 2020 Mar 30.

Dep. of Cardiac Surgery, University of Leipzig, Heartcenter, Leipzig, Germany.

Purpose: Heart failure (HF) affects more than 6 million adults in the U.S and is associated with significant morbidity and mortality. The majority of HF patients suffer from either ischemic (ICM) or dilated (DCM) cardiomyopathy. Read More

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http://dx.doi.org/10.1016/j.healun.2020.01.1088DOI Listing

Impact of Bleeding Complications on Outcomes Following Total Artificial Heart Implantation.

J Heart Lung Transplant 2020 Apr 30;39(4S):S150. Epub 2020 Mar 30.

Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA.

Purpose: Bleeding complications are well recognized phenomena following left ventricular assist device (LVAD) implantation and have been associated with increased morbidity and mortality. This complication and its consequences, however, remain undefined for total artificial heart (TAH) implantation.

Methods: A prospectively maintained database was used to identify all patients receiving TAH from January 2012 to May 2019 at a single institution. Read More

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http://dx.doi.org/10.1016/j.healun.2020.01.1083DOI Listing