Echocardiographic Strain Analysis for the Early Detection of Myocardial Structural Abnormality and Initiation of Drug Therapy in a Mouse Model of Dilated Cardiomyopathy.
- Minjuan Zheng,
- Feng Pan,
- Ying Liu,
- Zhenzhou Li,
- Xiaodong Zhou,
- Xin Meng,
- Liwen Liu,
- Shuping Ge
Ultrasound Med Biol 2017 Sep 20. Epub 2017 Sep 20.
Department of Ultrasound, Xijing Hospital, Fourth Military Medical University, Xi'an, China; Pediatric Cardiology, Drexel University College of Medicine, Philadelphia, Pennsylvania, USA. Electronic address:
This study aimed to evaluate the role of echocardiography-based strain analysis in the early diagnosis and guidance for management of dilated cardiomyopathy (DCM). Muscular dystrophy mice (which spontaneously develop DCM) and control (C57 BL/6 J) mice were sequentially evaluated by ultrasound biomicroscopy, conventional left ventricle (LV) measurement, two-dimensional (2-D) strain analysis and myocardial histologic analysis for 12 consecutive months. Significant alternation of LV remodeling and dysfunction could be detected by conventional echocardiography after 9 mo, by strain analysis after 5 mo and by histologic analysis after 4 mo. Read More