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    Parathyroid hormone serum concentration in Central European patients with non-ischemic heart failure as a potential marker of disease severity and poor prognosis.
    Endokrynol Pol 2017 Feb 23. Epub 2017 Feb 23.
    Department of Cardiology in Zabrze, Medical University of Silesia in Katowice.
    IntroductionParathyroid hormone (PTH) might be considered as a potential marker of disease severity and worse prognosis in heart failure (HF) patients. ObjectivesTo assess PTH, vitamin D, phosphorus (P) and total calcium (Ca2+) serum concentrations in Central European patients suffering from HF of non-ischemic origin compared to non-HF volunteers.To evaluate potential correlations among the enumerated parameters, established markers of worse prognosis and declared sun exposure. Read More

    [Catheter ablation of ventricular tachycardia : What have we achieved?]
    Herz 2017 Feb 22. Epub 2017 Feb 22.
    Zentrum für Kardiologie, Klinik für Kardiologie 2/Rhythmologie, Universitätsmedizin Mainz, Langenbeckstr. 1, 55131, Mainz, Deutschland.
    The role of catheter ablation in patients with ventricular tachycardia (VT) has evolved over the last two decades into an established treatment option. In patients with idiopathic VT catheter ablation is the gold standard treatment option with high effectiveness and low risk of complications. Due to the high risk of side effects the use of antiarrhythmic drugs is only indicated in exceptional cases. Read More

    Genetics and genomics of dilated cardiomyopathy and systolic heart failure.
    Genome Med 2017 Feb 22;9(1):20. Epub 2017 Feb 22.
    National Heart Lung Institute, Imperial College London, Cale Street, London, SW3 6LY, UK.
    Heart failure is a major health burden, affecting 40 million people globally. One of the main causes of systolic heart failure is dilated cardiomyopathy (DCM), the leading global indication for heart transplantation. Our understanding of the genetic basis of both DCM and systolic heart failure has improved in recent years with the application of next-generation sequencing and genome-wide association studies (GWAS). Read More

    Left ventricular function and exercise performance in idiopathic dilated cardiomyopathy: role of tissue Doppler imaging.
    J Cardiovasc Med (Hagerstown) 2017 Apr;18(4):230-236
    aCardiovascular Department, 'Ospedali Riuniti'bPostgraduate School of Cardiovascular Sciences, University of TriestecCardiovascular Center, Health Authority No. 1, TriestedCardiologic Center Monzino, IRCCS, Milano, Italy.
    Background: To examine the relationship between left ventricular (LV) function evaluated at echocardiography and exercise performance in idiopathic dilated cardiomyopathy (IDCM) patients.

    Methods And Results: We enrolled 76 consecutive IDCM patients in sinus rhythm, undergoing cardiopulmonary exercise testing and echocardiography [49 ± 13 years old; LV ejection fraction 31 ± 7%, LV end-diastolic volume 96 ± 31 ml/m; peak oxygen consumption (peak VO2/kg) 18 ± 5.6 ml/kg/min]. Read More

    Patients 60 years of age and older should have the same chance for heart transplantation or not?
    J Huazhong Univ Sci Technolog Med Sci 2017 Feb 22;37(1):57-62. Epub 2017 Feb 22.
    Department of Cardiovascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
    Heart transplantation is considered the best treatment modality for advanced heart disease. While old age has conventionally been considered a contraindication for heart transplantation due to the reported adverse effect of advanced age, however donor hearts' shortage continues to stimulate the discussion about the recipient's upper age limit. Our study was based on a retrospective analysis for the results of 52 (18%) patients aged 60 years and older undergoing heart transplantation between May 2008 and December 2015, and these patients were compared with 236 (82%) adult recipients who were younger than 60 years at the time of transplantation and during the same period. Read More

    Tooth extraction in a patient after autologous skeletal myoblast sheet transplantation for severe dilated cardiomyopathy.
    Ann Med Surg (Lond) 2017 Mar 1;15:34-36. Epub 2017 Feb 1.
    Department of Clinical Oral Oncology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan.
    The authors describe the first case of tooth extraction in a patient treated with autologous skeletal myocardial sheet transplantation for severe dilated cardiomyopathy. This condition is associated with significant morbidity and mortality that may have identifiable causes or may be idiopathic or inherited. In addition to local disinfection, antimicrobial prophylaxis and continuous anticoagulant therapy during the perioperative period of tooth extraction were needed to prevent infective endocarditis and ensure the success of regenerative therapy of the heart. Read More

    ZNF307 (Zinc Finger Protein 307) Acts as a Negative Regulator of Pressure Overload-Induced Cardiac Hypertrophy.
    Hypertension 2017 Feb 21. Epub 2017 Feb 21.
    From the Institute of Metabolic Disease, Department of Cardiology (X.-D.Y., B.-L.Z., Z.-R.Z.), and Department of Clinical Pharmacy (C.-J.Y., C.L., Y.-X.L, Q.-Q.H., W.-W.Z., N.N., X.Y., Z.-R.W., B.-L.S., Z.-R.Z.), Harbin Medical University Cancer Hospital, Heilongjiang Academy of Medical Science, Key Laboratories of Education Ministry for Myocardial Ischemia Mechanism and Treatment, P. R. China.
    Pathological cardiac hypertrophy is a key risk factor for heart failure. We found that the protein expression levels of the ZNF307 (zinc finger protein 307) were significantly increased in heart samples from both human patients with dilated cardiomyopathy and mice subjected to aortic banding. Therefore, we aimed to elucidate the role of ZNF307 in the development of cardiac hypertrophy and to explore the signal transduction events that mediate the effect of ZNF307 on cardiac hypertrophy, using cardiac-specific ZNF307 transgenic (ZNF307-TG) mice and ZNF307 global knockout (ZNF307-KO) mice. Read More

    CRT-Induced Ventricular Tachyarrhythmia: What's the mechanism?
    Pacing Clin Electrophysiol 2017 Feb 21. Epub 2017 Feb 21.
    Heart Rhythm Service, Kingston General Hospital, Queen's University, Kingston, Ontario, Canada.
    A 56-year-old woman with non-ischemic dilated cardiomyopathy and severe left ventricular systolic dysfunction received cardiac resynchronization defibrillator therapy (CRT-D; St Jude Medical Quadra Assura, CA, USA), for primary prevention and management of heart failure. This article is protected by copyright. All rights reserved. Read More

    Results of Late Gadolinium Enhancement in Children Affected by Dilated Cardiomyopathy.
    Front Pediatr 2017 6;5:13. Epub 2017 Feb 6.
    Department of Imaging, Bambino Gesù - Children's Hospital IRCCS , Rome , Italy.
    Background: Little is known about the clinical value of late gadolinium enhancement (LGE), in children affected by dilated cardiomyopathy (DCM).

    Materials And Methods: We retrospectively evaluated 15 patients (8 ± 6 years, 6 males) with diagnosis of DCM who underwent cardiac magnetic resonance since 2014. All scans were performed with a 1. Read More

    Clinical impact of the presence of macrophages in endomyocardial biopsies of patients with dilated cardiomyopathy.
    Eur J Heart Fail 2017 Feb 20. Epub 2017 Feb 20.
    Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center, 5-7-1 Fujishiro-dai, Suita, Osaka, 565-8565, Japan.
    Background: Dilated cardiomyopathy (DCM) is the most common cardiomyopathy and causes left ventricular enlargement and contractile dysfunction, with a poor prognosis. The mechanisms underlying the disease process have not been precisely identified, but recent evidence has suggested that the activation of myocardial inflammation is involved in the deterioration associated with the condition.

    Methods And Results: Biopsy samples from 182 consecutive DCM patients were immunohistochemically stained with antibodies specific to CD3 (T lymphocytes), CD68 (whole macrophages), and CD163 (M2 macrophages), and each type of infiltrating cell was counted. Read More

    Specifics of fetuin-A levels in distinct types of chronic heart failure.
    J Clin Lab Anal 2017 Feb 18. Epub 2017 Feb 18.
    Division of Cardiology, Angiology, Pneumology and Intensive Medical Care, Department of Internal Medicine I, University Hospital Jena, Friedrich Schiller University Jena, Jena, Germany.
    Introduction: Fetuin-A has been described to correlate inversely with vascular calcification both in animal models but also in patients with heart and renal disease. In this current study, we sought to investigate whether fetuin-A might be a useful marker for the discrimination of ischemic (ICM) from dilated cardiomyopathy (DCM).

    Methods: A total of 124 non-consecutive patients were included in this study, 59 patients suffered from ICM and 65 patients from DCM. Read More

    Implantable cardioverter/defibrillators for primary prevention in dilated cardiomyopathy post-DANISH: an updated meta-analysis and systematic review of randomized controlled trials.
    Clin Res Cardiol 2017 Feb 17. Epub 2017 Feb 17.
    Division of Cardiology, Pulmonology and Vascular Medicine, Department of Internal Medicine, Heinrich-Heine-University, Moorenstr. 5, 40225, Düsseldorf, Germany.
    Background: Sudden cardiac death (SCD) is frequent in patients with heart failure due to dilated cardiomyopathy (DCM). Implantable cardioverter/defibrillator (ICD) device therapy is currently used for primary prevention. However, publication of the DANISH trial has recently given reason for doubt, showing no significant improvement in all-cause mortality in comparison to contemporary medical therapy. Read More

    Interleukin-1β levels predict long-term mortality and need for heart transplantation in ambulatory patients affected by idiopathic dilated cardiomyopathy.
    Oncotarget 2017 Feb 15. Epub 2017 Feb 15.
    Cardiovascular Department, Azienda Sanitaria Universitaria Integrata di Trieste and University of Trieste, Trieste, Italy.
    Aims: The prognostic stratification of patients with Idiopathic Dilated Cardiomyopathy (iDCM) is a difficult task. Here, we assessed the additive value of the evaluation of biomarkers of inflammasome activation and systemic inflammation for the long-term risk stratification of iDCM patients.

    Methods And Results: We studied 156 ambulatory iDCM patients (mean age 58 years, 77% men, 79% in NYHA class 1-2, median Left Ventricular Ejection Fraction (LVEF) 35%, mean sodium 139 mEq/L, median BNP 189 pg/mL, median IL-1 beta (IL-1β) 1. Read More

    Whole exome sequencing identified 1 base pair novel deletion in BCL2-associated athanogene 3 (BAG3) gene associated with severe dilated cardiomyopathy (DCM) requiring heart transplant in multiple family members.
    Am J Med Genet A 2017 Mar;173(3):699-705
    Physiology and Experimental Medicine, The Hospital for Sick Children and Research Institute, Toronto, Ontario, Canada.
    Dilated cardiomyopathy (DCM) is characterized by dilation and impaired contraction of the left ventricle or both ventricles. Among hereditary DCM, the genetic causes are heterogeneous, and include mutations encoding cytoskeletal, nucleoskeletal, mitochondrial, and calcium-handling proteins. We report three severely affected males, in a four-generation pedigree, with DCM phenotype who underwent cardiac transplant. Read More

    Left ventricular non-compaction in a patient with ankylosing.
    J Cardiovasc Thorac Res 2016 30;8(4):188-189. Epub 2016 Dec 30.
    University at Buffalo, Buffalo, New York, 14214, USA.
    A 58 years old male with a long-standing history of HLA-B27 positive ankylosing spondylitis presented with increasing fatigue and dyspnea on exertion. He had left ventricular dysfunction and enlargement, flail right coronary leaflet of aortic valve with severe eccentric aortic insufficiency along with left ventricular non-compaction in echocardiography. The most common cardiac manifestations of ankylosing spondylitis are aortic insufficiency and conduction disturbances. Read More

    Roles of Angiotensin Peptides and Recombinant Human ACE2 in Heart Failure.
    J Am Coll Cardiol 2017 Feb;69(7):805-819
    Division of Cardiology, Department of Medicine, University of Alberta, Edmonton, Canada; Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Canada. Electronic address:
    Background: The renin-angiotensin system (RAS) is activated in heart failure (HF) and inhibition of RAS is a mainstay therapy for HF. Angiotensin-converting enzyme 2 (ACE2) and its product, angiotensin 1-7 (Ang-[1-7]), are important negative regulators of the RAS.

    Objectives: A comprehensive examination of angiotensin peptide levels and therapeutic effects of recombinant human ACE2 (rhACE2) on peptide metabolism was evaluated in human plasma and explanted heart tissue from patients with HF. Read More

    CD4(+) CD25(+) GARP(+) Tregs display a compromised suppressive function in patients with dilated cardiomyopathy.
    Immunology 2017 Feb 16. Epub 2017 Feb 16.
    Laboratory of Cardiovascular Immunology, Institute of Cardiology, Union Hospital, TongJi Medical College, Huahzong University of Science and Technology, Wuhan, China.
    Dilated cardiomyopathy (DCM) is a lethal inflammatory heart disease and closely connected with dysfunction of the immune system. Glycoprotein -A repetitions predominant (GARP) expressed on activated CD4(+) T cells with suppressive activity has been established. This study aimed to investigate the frequency and function of circulating CD4(+) CD25(+) GARP(+) regulatory T cells (Tregs) in DCM. Read More

    Cardiovascular drug utilization post-implant is related to clinical outcome in heart failure patients receiving cardiac resynchronization therapy.
    Cardiol J 2017 Feb 15. Epub 2017 Feb 15.
    Lund University, Skane University Hospital, Arrhythmia Clinic, Lund, Sweden.
    Background: In select patients with heart failure, cardiac resynchronization therapy (CRT) is the most common complementary treatment besides medical treatment. We aimed to assess the association between post CRT-implant changes in cardiovascular medication and cardiovascular mortality and heart failure hospitalization.

    Methods: 211 patients on optimal medical therapy eligible for CRT were retrospectively included in this study (72 ± 7 years, 80% male, 66% left bundle branch block [LBBB], 48% dilated cardiomyopathy [DCMP]) and investigated at baseline and after 6 months . Read More

    Fragmented QRS as a Marker of Electrical Dyssynchrony to Predict Inter-Ventricular Conduction Defect by Subsequent Echocardiographic Assessment in Symptomatic Patients of Non-Ischemic Dilated Cardiomyopathy.
    Cardiol Res 2016 Aug 5;7(4):140-145. Epub 2016 Sep 5.
    Department of Cardiology, LPS Institute of Cardiology, G.S.V.M. Medical College, Kanpur, Uttar Pradesh 208002, India.
    Background: Left ventricular (LV) dyssynchrony frequently occurs in patients with heart failure (HF). QRS ≥ 120 ms is a surrogate marker of electrical dyssynchrony, which occurs in only 30% of HF patients. In contrary, in those with normal QRS (nQRS) duration, LV dyssynchrony has been reported in 20-50%. Read More

    Transaxillary Subpectoral Placement of Cardiac Implantable Electronic Devices in Young Female Patients.
    Arch Plast Surg 2017 Jan 20;44(1):34-41. Epub 2017 Jan 20.
    Department of Plastic and Reconstructive Surgery, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
    Background: The current indications of cardiac implantable electronic devices (CIEDs) have expanded to include young patients with serious cardiac risk factors, but CIED placement has the disadvantage of involving unsightly scarring and bulging of the chest wall. A collaborative team of cardiologists and plastic surgeons developed a technique for the subpectoral placement of CIEDs in young female patients via a transaxillary approach.

    Methods: From July 2012 to December 2015, subpectoral CIED placement via an axillary incision was performed in 10 young female patients, with a mean age of 25. Read More

    Differences in Presentation and Outcomes Between Children With Familial Dilated Cardiomyopathy and Children With Idiopathic Dilated Cardiomyopathy: A Report From the Pediatric Cardiomyopathy Registry Study Group.
    Circ Heart Fail 2017 Feb;10(2)
    From the Department of Pediatrics, Miller School of Medicine, University of Miami, FL (P.R., S.E.L.); Department of Pediatrics, Wayne State University School of Medicine, Children's Hospital of Michigan, Detroit (J.D.W., S.E.L.); Sanofi Genzyme Corporation, Boston, MA (G.F.C.); The Heart Institute, Le Bonheur Children's Hospital, Memphis, TN (J.A.T.); The Heart Institute, Cincinnati Children's Hospital Medical Center, OH (J.L.J.); Department of Cardiology, Boston Children's Hospital, MA (L.A.S., M.L., S.D.C.); Department of Pediatrics, Vanderbilt University School of Medicine, Monroe Carell Jr. Children's Hospital at Vanderbilt, Nashville, TN (S.A.W.); Department of Pediatrics, Washington University School of Medicine, St. Louis, MO (C.E.C.); Indiana University School of Medicine, Indianapolis (S.M.W.); Department of Pediatrics, Albert Einstein College of Medicine, The Children's Hospital at Montefiore, Bronx, NY (D.T.H.); Department of Pediatrics, Columbia University Medical Center, New York, NY (W.K.C.); and University of North Carolina at Chapel Hill (C.C.).
    Background: Research comparing the survival of children with familial dilated cardiomyopathy (FDCM) to that of children with idiopathic dilated cardiomyopathy (IDCM) has produced conflicting results.

    Methods And Results: We analyzed data from children with FDCM or IDCM using the National Heart, Lung, and Blood Institute-funded Pediatric Cardiomyopathy Registry. Compared to children with IDCM (n=647), children with FDCM (n=223) were older (mean 6. Read More

    A Randomized Comparative Study on the Efficacy of Intracoronary Infusion of Autologous Bone Marrow Mononuclear Cells and Mesenchymal Stem Cells in Patients With Dilated Cardiomyopathy.
    Int Heart J 2017 Feb 13. Epub 2017 Feb 13.
    Department of Cardiology, Henan Cardiovascular Hospital, Zhengzhou University People's Hospital.
    Stem cell therapy has shown therapeutic benefit in dilated cardiomyopathy (DCM), but doubt remains about the most appropriate stem cell subpopulation. The current study compared the efficacy of intracoronary administration of bone marrow mononuclear cells (BMMC) or mesenchymal stem cells (BMSC) in patients with DCM.Fifty-three patients with DCM and reduced (< 40%) left ventricular ejection fraction (LVEF), were randomized to intracoronary infusion of BMMC (BMMC group, n = 16) or BMSC (BMSC group, n = 17) or equal volume normal saline (CTRL group, n = 20). Read More

    Dilated cardiomyopathy.
    Lancet 2017 Feb 9. Epub 2017 Feb 9.
    St Vincent's Hospital, Sydney, NSW, Australia; Victor Chang Cardiac Research Institute, Sydney, NSW, Australia.
    Dilated cardiomyopathy is defined by the presence of left ventricular dilatation and contractile dysfunction. Genetic mutations involving genes that encode cytoskeletal, sarcomere, and nuclear envelope proteins, among others, account for up to 35% of cases. Acquired causes include myocarditis and exposure to alcohol, drugs and toxins, and metabolic and endocrine disturbances. Read More

    The prognostic value of right ventricular long axis strain in non-ischaemic dilated cardiomyopathies using standard cardiac magnetic resonance imaging.
    Eur Radiol 2017 Feb 10. Epub 2017 Feb 10.
    Department of Cardiology, Angiology and Pneumology, University of Heidelberg, Im Neuenheimer Feld 410, Heidelberg, 69120, Germany.
    Objective: To investigate the association of right ventricular long axis strain (RV-LAS), a parameter of longitudinal function, with outcome in patients with non-ischaemic dilated cardiomyopathy (NIDCM).

    Methods: In 441 patients with NIDCM, RV-LAS was analysed retrospectively by measuring the length between the epicardial border of the left ventricular apex and the middle of a line connecting the origins of the tricuspidal valve leaflets in end-diastole and end-systole on non-contrast standard cine sequences.

    Results: The primary endpoint (cardiac death or heart transplantation) occurred in 41 patients, whereas 95 reached the combined endpoint (including cardiac decompensation and sustained ventricular arrhythmias) during a median follow-up of 4. Read More

    Assessment of Myocardial Microstructural Dynamics by In Vivo Diffusion Tensor Cardiac Magnetic Resonance.
    J Am Coll Cardiol 2017 Feb;69(6):661-676
    Cardiovascular Magnetic Resonance Unit, Royal Brompton and Harefield National Health Service Foundation Trust, London, United Kingdom; National Heart and Lung Institute, Imperial College London, London, United Kingdom; National Institute for Health Research Cardiovascular Biomedical Research Unit, Royal Brompton and Harefield National Health Service Foundation Trust, and Imperial College London, London, United Kingdom.
    Background: Cardiomyocytes are organized in microstructures termed sheetlets that reorientate during left ventricular thickening. Diffusion tensor cardiac magnetic resonance (DT-CMR) may enable noninvasive interrogation of in vivo cardiac microstructural dynamics. Dilated cardiomyopathy (DCM) is a condition of abnormal myocardium with unknown sheetlet function. Read More

    Takotsubo Syndrome After Cardiopulmonary Resuscitation During Emergency Cesarean Delivery.
    Obstet Gynecol 2017 Mar;129(3):521-524
    Departments of Obstetrics and Gynecology and Cardiology, Klinikum Kempten Oberallgäu, Kempten, Germany.
    Background: Takotsubo syndrome is a rare, stress-related, and reversible form of acute heart failure primarily affecting postmenopausal women. It is characterized by left ventricular dysfunction with a classic apical and midventricular wall motion abnormality (apical ballooning).

    Case: A 28-year-old woman, gravida 2 para 1, at 30 4/7 weeks of gestation was admitted with fetal bradycardia, a fully dilated cervix, and breech presentation. Read More

    Left ventricular phase entropy: Novel prognostic predictor in patients with dilated cardiomyopathy and narrow QRS.
    J Nucl Cardiol 2017 Feb 7. Epub 2017 Feb 7.
    Department of Cardiology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, Aichi, 466-8550, Japan.
    Background: The prognostic impact and pathophysiology of global left ventricular mechanical dyssynchrony (LVMD), namely mechanical dyssynchrony of whole left ventricle, as assessed by phase analysis of electrocardiographically gated (ECG-gated) myocardial perfusion SPECT has not been clearly elucidated in patients with dilated cardiomyopathy (DCM) and narrow QRS complex (<120 ms).

    Methods And Results: Forty-six patients with DCM underwent ECG-gated myocardial (99m)Tc-sestamibi perfusion SPECT and endomyocardial biopsy. LV phase entropy was automatically calculated using a phase analysis of ECG-gated myocardial perfusion SPECT. Read More

    [Primary Lung Cancer Associated with Dilated Phase of Hypertrophic Cardiomyopathy;Report of a Case].
    Kyobu Geka 2017 Feb;70(2):147-150
    Department of General, Endoscopic, Cardiovascular, Thoracic and Breast Surgery, Tsugaru General Hospital, Goshogawara, Japan.
    A 66-year-old man diagnosed as dilated phase of hypertrophic cardiomyopathy (D-HCM) was pointed out an abnormal shadow on routine chest radiography. The patient had past medical history of hypertension, congestive heart failure and chronic obstructive pulmonary disease. The computed tomography showed a 3. Read More

    [Surgical Regeneration Therapy Using Myoblast Sheets for Severe Heart Failure].
    Kyobu Geka 2017 Jan;70(1):9-13
    Division of Cardiovascular Surgery, Osaka University Graduate School of Medicine, Suita, Japan.
    Heart failure is a life-threatening disorder worldwide, and the current end-stage therapies for severe heart failure are replacement therapies such as ventricular-assist devices and heart transplantation. Although these therapies have been reported to be useful, there are many issues in terms of the durability, complications, limited donors, adverse effect of continuous administration of immunosuppressive agents, and high costs involved. Recently, regenerative therapy based on genetic, cellular, or tissue engineering techniques has gained attention as a new therapy to overcome the challenges encountered in transplantation medicine. Read More

    Exome Sequencing Identifies a Novel DES Mutation (R227C) in a Chinese Dilated Cardiomyopathy Family.
    Cardiology 2017 Feb 8;137(2):78-82. Epub 2017 Feb 8.
    Department of Anesthesiology, The Second Xiangya Hospital, Central South University, Changsha, China.
    Objectives: Dilated cardiomyopathy (DCM) is a common disease in the clinic, and it is the leading cause of heart failure and sudden cardiac death. Previous studies have proven that genetic factors play a crucial role in the occurrence of DCM; more than 50 disease genes including desmin (DES) have been identified to be associated with DCM. At present, most DES mutations are reported in desmin-related myofibrilla myopathy patients, but variants leading to isolated DCM are rarely reported. Read More

    Peripartum Cardiomyopathy Characteristics and Outcomes in Canadian Aboriginal and Non-Aboriginal Women.
    Can J Cardiol 2016 Nov 11. Epub 2016 Nov 11.
    Section of Cardiology, Rady Faculty of Health Sciences and Max Rady College of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada. Electronic address:
    Background: Peripartum cardiomyopathy (PPCM) is a heterogeneous condition characterized by heart failure and left ventricular dysfunction (left ventricular ejection fraction [LVEF] < 45%) in the absence of an alternative cause and a previous diagnosis of cardiomyopathy. The Aboriginal population (Inuit, First Nations, Metis) of Canada often has barriers to health care, which can lead to delays in diagnosis and treatment. Our objectives are to describe PPCM in a Canadian population, and to determine if Canadian Aboriginal women have worse clinical outcomes than non-Aboriginal women. Read More

    Adeno-associated Virus Serotype 9 - Driven Expression of BAG3 Improves Left Ventricular Function in Murine Hearts with Left Ventricular Dysfunction Secondary to a Myocardial Infarction.
    JACC Basic Transl Sci 2016 Dec;1(7):647-656
    Department of Medicine, the Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania.
    Objectives: The present study was undertaken to test the hypothesis that gene delivery of BCL2-Associated Athanogene 3 (BAG3) to the heart of mice with left ventricular dysfunction secondary to a myocardial infarction could enhance cardiac performance.

    Background: BAG3 is a 575 amino acid protein that has pleotropic functions in the cell including pro-autophagy and anti-apoptosis. Mutations in BAG3 have been associated with both skeletal muscle dysfunction and familial dilated cardiomyopathy and BAG3 levels are diminished in non-familial heart failure. Read More

    An unusual case of non-compaction cardiomyopathy associated with coronary artery disease.
    Hellenic J Cardiol 2017 Feb 2. Epub 2017 Feb 2.
    Department of Cardiology, Paphos General Hospital, Paphos, Cyprus. Electronic address:
    Non-compaction cardiomyopathy (NCC) is a rare cause of heart failure, characterized by the presence of extensive myocardial trabeculation and deep intertrabecular recesses. Herein, we report a 71-year-old man, who travelled a week earlier by plane, and was hospitalised due to pneumonia. Ten days later, while being in the hospital, he developed acute dyspnoea, tachypnea and hypotension. Read More

    Multicenter evaluation of a national organ sharing policy for highly sensitized patients listed for heart transplantation in Canada.
    J Heart Lung Transplant 2017 Jan 6. Epub 2017 Jan 6.
    Division of Cardiac Sciences, Libin Cardiovascular Institute, Foothills Medical Center, University of Calgary, Calgary, Alberta; Canada.
    Background: Transplantation of sensitized recipients has been associated with increased risk of post-transplant complications. In 2010, the Canadian Cardiac Transplant Network (CCTN) created a unique status listing for highly sensitized heart transplant candidates. Status 4S listing requires calculated panel-reactive antibody (cPRA) level >80% as the sole listing criteria and enables geographic expansion of the donor pool by providing national access. Read More

    A randomized study of autologous bone marrow-derived stem cells in pediatric cardiomyopathy.
    J Heart Lung Transplant 2017 Jan 5. Epub 2017 Jan 5.
    Department of Cardiology, Great Ormond Street Hospital, London, United Kingdom. Electronic address:
    Background: Bone marrow mononuclear cell fraction has been used as therapy for dilated cardiomyopathy in adults. Although case series are reported, there are no randomized controlled studies in children.

    Methods: We designed a randomized, crossover, controlled pilot study to determine safety and feasibility of intracoronary stem cell therapy in children. Read More

    Psoriasis and Cardiomyopathy: A Review of the Literature.
    South Med J 2017 Feb;110(2):97-100
    From the Department of Cardiology, University of Alabama at Birmingham, Birmingham, Alabama, and the Division of Cardiovascular Diseases, University of Tennessee Health Science Center, Memphis.
    Psoriasis is an idiopathic chronic immune-mediated skin condition in which the body's immune system undergoes several derangements, including increased antigen presentation by T cells and increased T-helper cell type 1 cytokines, resulting in skin lesions as well as arthritis. Despite that cardiovascular involvement in psoriasis is common and reported in up to 47% of cases, this association is not well recognized by physicians, dermatologists, and cardiologists. Psoriasis is considered the most prevalent autoimmune disease in the United States and affects approximately 7. Read More

    Transcriptome-wide co-expression analysis identifies LRRC2 as a novel mediator of mitochondrial and cardiac function.
    PLoS One 2017 3;12(2):e0170458. Epub 2017 Feb 3.
    Cardiovascular Center, Medical College of Wisconsin, Milwaukee, WI, United States of America.
    Mitochondrial dysfunction contributes to myriad monogenic and complex pathologies. To understand the underlying mechanisms, it is essential to define the full complement of proteins that modulate mitochondrial function. To identify such proteins, we performed a meta-analysis of publicly available gene expression data. Read More

    Diagnostic and Prognostic Value of Long-Axis Strain and Myocardial Contraction Fraction Using Standard Cardiovascular MR Imaging in Patients with Nonischemic Dilated Cardiomyopathies.
    Radiology 2017 Feb 2:161184. Epub 2017 Feb 2.
    From the Department of Cardiology, Angiology, and Pneumology (N.A., J.H.R., T.F., F.A., F.a.d.S., M.M.H., E.G., H.A.K., M.G.F., S.J.B.), University of Heidelberg, Im Neuenheimer Feld 410, Heidelberg 69120, Germany; Department of Cardiology, Solothurner Spitäler, Solothurn, Switzerland (N.A.); DZHK (German Centre for Cardiovascular Research), Heidelberg, Germany (H.A.K.); and Radiology Center, Sinsheim-Eberbach-Erbach-Walldorf-Heidelberg, Germany (S.J.B.).
    Purpose To assess the utility of established functional markers versus two additional functional markers derived from standard cardiovascular magnetic resonance (MR) images for their incremental diagnostic and prognostic information in patients with nonischemic dilated cardiomyopathy (NIDCM). Materials and Methods Approval was obtained from the local ethics committee. MR images from 453 patients with NIDCM and 150 healthy control subjects were included between 2005 and 2013 and were analyzed retrospectively. Read More

    Cartilage Oligomeric Matrix Protein: Matricellular and Matricrine Signaling in Cardiovascular Homeostasis and Disease.
    Curr Vasc Pharmacol 2017 Feb 1. Epub 2017 Feb 1.
    Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University; Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing, China.
    Cardiovascular (CV) diseases remain a leading cause of morbidity and mortality in the world. Increasing the understanding of the pathogenesis of various CV diseases may provide novel therapeutic targets to improve their prevention and treatment. Cartilage oligomeric matrix protein (COMP), also known as thrombospondin-5 (TSP-5), is a matricellular protein that is abundantly expressed in both cartilage and the CV system. Read More

    Short-term and long-term models of doxorubicin-induced cardiomyopathy in rats: A comparison of functional and histopathological changes.
    Exp Toxicol Pathol 2017 Jan 30. Epub 2017 Jan 30.
    Cardiology Division, Faculty of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, São Paulo, 14048-900, Brazil. Electronic address:
    Objectives: Doxorubicin (DXR), an anthracyclic antineoplastic agent, is one of the most commonly drug utilized to induce dilated cardiomyopathy (DCM) and heart failure (HF), but the well optimized protocol for cardiomyopathy induction leading to development of cardiac systolic dysfunction is unclear. This study aims to critically compare short-term and long-term DXR injection protocols for the induction of DCM in rats.

    Methods: Animals were allocated into 3 experimental groups: a ST (short-term DXR injection) group, in which animals received 6 intraperitoneal (i. Read More

    Titin-truncating mutations in dilated cardiomyopathy: the long and short of it.
    Curr Opin Cardiol 2017 Feb 1. Epub 2017 Feb 1.
    aVictor Chang Cardiac Research Institute, Darlinghurst bFaculty of Medicine, University of New South Wales, Kensington cDepartment of Cardiology, St Vincent's Hospital, Darlinghurst, New South Wales, Australia.
    Purpose Of Review: Truncating variants in the TTN gene (TTNtv) are frequently identified in patients with dilated cardiomyopathy (DCM) but are also present in apparently healthy people in the general population. Consequently, there is considerable uncertainty about what it means for any single individual if a TTNtv is found. The aim of this review is to summarize current evidence implicating TTNtv in DCM pathogenesis and to provide some interpretative guidelines for clinical management. Read More

    Left ventricular systolic dysfunction in two patients with ankylosing spondylitis: What is the role of corticosteroids?
    Eur J Rheumatol 2016 Dec 5;3(4):179-181. Epub 2016 Apr 5.
    Department of Heart Failure and Transplantation, Rajaei Cardiovascular, Medical and Research Center, Iran, University of Medical Sciences, Tehran, Iran.
    Ankylosing spondylitis (AS) is a chronic inflammatory condition that most commonly affects the axial skeleton. The most common cardiac manifestation in patients with AS is the aortic root and valve disease, followed by conduction and rhythm abnormalities, decreased coronary flow reserve, myocardial infarction, and diastolic dysfunction. However, the presence of systolic dysfunction has been less described in patients with AS. Read More

    Adverse left ventricular remodeling by glycoprotein nonmetastatic melanoma protein B in myocardial infarction.
    FASEB J 2017 Feb 25;31(2):556-568. Epub 2016 Oct 25.
    Max Delbrück Center for Molecular Medicine, Berlin, Germany;
    Cardiac diseases are the leading cause of death. Available treatment approaches are not sufficient to reverse persistent cardiac damage after injury; thus, the search for new therapeutic targets is essential. Our microarray-based screening in rat hearts 24 h after myocardial infarction (MI) yielded glycoprotein nonmetastatic melanoma protein B (GPNMB), which is known to be involved in inflammation and fibrosis after tissue injury. Read More

    Cardiac Channelopathies and Sudden Death: Recent Clinical and Genetic Advances.
    Biology (Basel) 2017 Jan 29;6(1). Epub 2017 Jan 29.
    Cardiovascular Genetics Center, IDIBGI, Girona 17190, Spain.
    Sudden cardiac death poses a unique challenge to clinicians because it may be the only symptom of an inherited heart condition. Indeed, inherited heart diseases can cause sudden cardiac death in older and younger individuals. Two groups of familial diseases are responsible for sudden cardiac death: cardiomyopathies (mainly hypertrophic cardiomyopathy, dilated cardiomyopathy, and arrhythmogenic cardiomyopathy) and channelopathies (mainly long QT syndrome, Brugada syndrome, short QT syndrome, and catecholaminergic polymorphic ventricular tachycardia). Read More

    THE UTILITY OF CARDIOPULMONARY EXERCISE TESTING FOR THE PREDICTION OF OUTCOMES IN AMBULATORY CHILDREN WITH DILATED CARDIOMYOPATHY.
    Transplantation 2017 Jan 31. Epub 2017 Jan 31.
    1Cardiology Service, Department of Paediatric Subspecialties, KK Women's and Children's Hospital, Singapore 229899 2Department of Pediatrics, University of Toronto, The Labatt Family Heart Centre, The Hospital for Sick Children, Toronto, Ontario, Canada, M5G 1X8 3Division of Pediatric Cardiology, Stollery Children's Hospital, Edmonton, Alberta, T6G 2B7.

    [The benefit of magnetic resonance for diagnosing cardiomyopathy and myocarditis].
    Vnitr Lek 2016 ;62(12):976-984
    Magnetic resonance is becoming an increasingly used examination in cardiology, since it greatly improves the accuracy of diagnosing of many heart diseases. At present magnetic resonance is the gold standard in assessing the volumes of the heart chambers and the systolic function of both ventricles. The possibility of detecting tissue characteristics to refine the diagnostics of different types of myocardial pathology is of essential importance. Read More

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