25,359 results match your criteria Cardiomyopathy Dilated

A new mutation in the ACTA1 gene possibly associated with dilated cardiomyopathy without concomitant myopathy.

Rev Esp Cardiol (Engl Ed) 2022 May 18. Epub 2022 May 18.

Unidad de Insuficiencia Cardiaca y Cardiopatías Familiares, Hospital Universitario Virgen de la Victoria, Instituto de Investigación Biomédica de Málaga (IBIMA), Málaga, Spain; Centro de Investigación en Red de Enfermedades Cardiovasculares (CIBERCV), Spain.

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Ventricular systolic dysfunction in dogs diagnosed with hypoadrenocorticism.

J Vet Cardiol 2022 Apr 23;41:231-235. Epub 2022 Apr 23.

Department of Small Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, 736 Wilson Road, East Lansing, Michigan, 48824, USA. Electronic address:

In human patients with hypoadrenocorticism, a secondary dilated cardiomyopathy is noted that has been reported to resolve with replacement steroid therapy. A similar secondary dilated cardiomyopathy in dogs with hypoadrenocorticism has not been previously described. We present three dogs concurrently diagnosed with hypoadrenocorticism and ventricular dilation with systolic dysfunction. Read More

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Dual Specific Phosphatase 7 Exacerbates Dilated Cardiomyopathy, Heart Failure, and Cardiac Death by Inactivating the ERK1/2 Signaling Pathway.

J Cardiovasc Transl Res 2022 May 20. Epub 2022 May 20.

Department of Cardiology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.

Heart failure is one of the most common but complicated end-stage syndromes in clinical practice. Dilated cardiomyopathy is a myocardial structural abnormality that is associated with heart failure. Dual-specificity phosphatases (DUSPs) are a group of protein phosphatases that regulate signaling pathways in numerous diseases; however, their physiological and pathological impact on cardiovascular disease remains unknown. Read More

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Development and validation of a nomogram to predict the risk of death within 1 year in patients with non-ischemic dilated cardiomyopathy: a retrospective cohort study.

Sci Rep 2022 May 20;12(1):8513. Epub 2022 May 20.

Department of Cardiology, The First Affiliated Hospital of Guangxi Medical University, No 6 Shuangyong Road, Nanning, Guangxi, 530021, People's Republic of China.

Predicting the chances mortality within 1 year in non-ischemic dilated cardiomyopathy patients can be very useful in clinical decision-making. This study has developed and validated a risk-prediction model for identifying factors contributing to mortality within 1 year in such patients. The predictive nomogram was constructed using a retrospective cohort study, with 615 of patients hospitalized in the First Affiliated Hospital of Guangxi Medical University between October 2012 and May 2020. Read More

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Alcohol Intake in Patients With Cardiomyopathy and Heart Failure: Consensus and Controversy.

Circ Heart Fail 2022 May 20:101161CIRCHEARTFAILURE121009459. Epub 2022 May 20.

Department of Cardiology, Hillerød Hospital, University of Copenhagen, Denmark. (C.T.-P.).

Alcohol is often cited to be a common cause of cardiomyopathy and heart failure. However, in most available population-based studies, a modest-to-moderate alcohol consumption has been associated with favorable effects on the cardiovascular system, including a lowered risk of heart failure, compared with no alcohol consumption. Available genetic epidemiological data have not supported a causal association between alcohol consumption and heart failure risk, suggesting that alcohol may not be a common cause of heart failure in the community. Read More

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Primary prevention implantable cardioverter-defibrillator use in non-ischemic dilated cardiomyopathy based on arrhythmic risk stratification and left ventricular reverse remodeling prediction.

Heart Fail Rev 2022 May 19. Epub 2022 May 19.

Cardiology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt.

Sudden cardiac death (SCD) and significant ventricular arrhythmias in patients with dilated cardiomyopathy (DCM) have been markedly reduced over the last couple of decades as a result of the advances in pharmacological and non-pharmacological treatment. Primary prevention implantable cardioverter-defibrillator (ICD) plays an important role in the treatment of patients at risk of SCD caused by ventricular arrhythmias. However, the arrhythmic risk stratification in patients with DCM remains extremely challenging, and the decision for primary prevention ICD implantation based on left ventricular ejection fraction (LVEF) solely appears to be insufficient. Read More

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Prognosis of Adults With Isolated Left Ventricular Non-Compaction: Results of a Prospective Multicentric Study.

Front Cardiovasc Med 2022 2;9:856160. Epub 2022 May 2.

Cardiology Department, Assistance Publique Hopitaux de Marseille (APHM), La Timone Hospital, Marseille, France.

Background: Whether left ventricular non-compaction (LVNC) bears a different prognosis than dilated cardiomyopathy (DCM) is still a matter of debate.

Methods: From a multicenter French prospective registry, we compared the outcomes of 98 patients with LVNC and 65 with DCM. The primary endpoint combined cardiovascular death, heart transplantation, and hospitalization for cardiovascular events. Read More

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Renal Interstitial Invasion by Group A : A Rare Presentation.

Case Rep Infect Dis 2022 9;2022:5881375. Epub 2022 May 9.

Division of Infectious Diseases, Akron Childrens Hospital, Akron, OH, USA.

We report the case of a 5-year-old who had interstitial invasion of his kidneys with group A (GAS). Glomeruli and tubules were relatively preserved. He recovered from this event and was admitted a couple of months later with dilated cardiomyopathy needing a heart transplant. Read More

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ST-elevation myocardial infarction in a young patient with Duchenne's muscular dystrophy: a case report.

Eur Heart J Case Rep 2022 May 16;6(5):ytac184. Epub 2022 May 16.

Cardiology Department, Portsmouth Hospitals University NHS Trust, Portsmouth, UK.

Background: Duchenne's muscular dystrophy (DMD) is an X-linked muscular disease which is caused by the absence of dystrophin. This results in the death of muscle cells and cardiomyocytes and consequent substitution by fat and fibrous tissue. The clinical translation of this is muscle weakness and cardiomyopathy. Read More

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High defibrillation threshold with right-sided ICD implantation was resolved by a dual coil lead via persistent left superior vena cava.

J Cardiol Cases 2022 May 22;25(5):262-265. Epub 2021 Nov 22.

Department of Cardiovascular, Renal and Metabolic Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan.

Persistent left superior vena cava (PLSVC) can be problematic when device implantation is scheduled from the left side because of the technical difficulty in delivering leads. Right-sided implantation is an alternative method, but there is a risk of a high defibrillation threshold (DFT). Transvenous implantation of an implantable cardioverter defibrillator (ICD) was scheduled for a 54-year-old man with idiopathic dilated cardiomyopathy and monomorphic non-sustained ventricular tachycardia, but computed tomography revealed the presence of a PLSVC. Read More

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Thrombosed stuck mitral valve during advanced mechanical circulatory support for post-cardiotomy shock.

J Cardiol Cases 2022 May 16;25(5):282-284. Epub 2021 Dec 16.

Department of Cardiovascular Surgery, Fujita Health University School of Medicine, Toyoake, Japan.

We report a case of mechanical prosthetic mitral valve thrombosis in a 52-year-old woman with previous diagnosis of dilated cardiomyopathy, who was supported with advanced mechanical circulatory support after urgent mechanical mitral valve replacement (MVR) and tricuspid annuloplasty. Difficult weaning from cardiopulmonary bypass needed support with veno-arterial extracorporeal membranous oxygenation and Impella (Abiomed Inc, Danvers, MA, USA), so-called ECPELLA. Temporary discontinuation of heparin and massive blood transfusion were necessary due to four times of reoperation for bleeding during ECPELLA support. Read More

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Contact dermatitis associated with wearable cardioverter-defibrillator.

J Cardiol Cases 2022 May 30;25(5):266-268. Epub 2021 Nov 30.

Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine, Yamagata, Japan.

A 51-year-old man with dilated cardiomyopathy was resuscitated from ventricular fibrillation. Twenty-days after using a wearable cardioverter-defibrillator (WCD) contact dermatitis with itching was evident and consistent with the self-gelling defibrillation electrodes patch on the back. Itching was controlled with clobetasol propionate application. Read More

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Successful implantation of left ventricular lead for a cardiac resynchronization therapy defibrillator through a persistent left superior vena cava using the anchor balloon technique.

J Cardiol Cases 2022 May 17;25(5):308-311. Epub 2021 Dec 17.

Department of Medical Science and Cardiorenal Medicine, Yokohama City University School of Medicine, Yokohama, Japan.

A 69-year-old woman was referred for upgrading implantable cardioverter defibrillator (ICD) to cardiac resynchronization therapy defibrillator (CRT-D) because of symptomatic heart failure due to dilated cardiomyopathy. Her electrocardiogram showed left bundle branch block and echocardiography showed severe left ventricular dysfunction. Venography confirmed the presence of persistent left superior vena cava (PLSVC), and occlusion of innominate vein and the coronary sinus (CS) ostium. Read More

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Diagnostic yield of genetic testing in heart transplant recipients with prior cardiomyopathy.

J Heart Lung Transplant 2022 Apr 9. Epub 2022 Apr 9.

Research Group Cardiovascular Diseases, GENCOR, University of Antwerp, Antwerp, Belgium; Department of Cardiology, Antwerp University Hospital, University of Antwerp, Antwerp, Belgium.

Background: The importance of genetic testing for cardiomyopathies has increased in the last decade. However, in heart transplant patients with former cardiomyopathy, genetic testing in retrospect is not routinely performed. We hypothesize that the yield of genetic testing in this population is considerable, and will have a major impact for both patients and relatives. Read More

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Estrogen Protects Cardiac Function and Energy Metabolism in Dilated Cardiomyopathy Induced by Loss of Cardiac IRS1 and IRS2.

Circ Heart Fail 2022 May 17:101161CIRCHEARTFAILURE121008758. Epub 2022 May 17.

Department of Nutrition, College of Agriculture and Life Sciences, Texas A&M University, College Station. (H.Y., W.Y., F.Z., Q.P., K.A., C.A., Y.S., S.G.).

Background: Type 2 diabetes (T2D) is a high-risk factor for incident of cardiovascular diseases. Women at young ages show a reduced incidence of both T2D and cardiovascular diseases compared with men, but these disparities disappear in postmenopausal women versus age-matched men. Thus, ovaries and ovarian hormones, such as estrogen, are expected to protect from T2D and cardiovascular diseases. Read More

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Diabetic mastopathy: A rare clinicopathologic entity with considerable autoimmune potential.

Int J Surg Case Rep 2022 May 4;95:107151. Epub 2022 May 4.

Department of Surgery, King Fahad Specialist Hospital, Dammam, Saudi Arabia.

Introduction And Importance: Diabetic mastopathy is a rare entity affecting diabetic patients. It has been previously linked to type 1 diabetes mellitus; however, due to the several accompanying conditions, a theory of autoimmune factors contributing to the origin of this condition has been on the rise. In this paper, we report a case of diabetic mastopathy associated with several autoimmune diseases to highlight the immunological potential of this condition. Read More

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HDAC6 modulates myofibril stiffness and diastolic function of the heart.

J Clin Invest 2022 May;132(10)

Department of Medicine, Division of Cardiology, and.

Passive stiffness of the heart is determined largely by extracellular matrix and titin, which functions as a molecular spring within sarcomeres. Titin stiffening is associated with the development of diastolic dysfunction (DD), while augmented titin compliance appears to impair systolic performance in dilated cardiomyopathy. We found that myofibril stiffness was elevated in mice lacking histone deacetylase 6 (HDAC6). Read More

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Clinical Profile and Risk Factors for Cardiac Death in Pediatric Patients With Primary Dilated Cardiomyopathy at a Tertiary Medical Center in China.

Front Pediatr 2022 28;10:833434. Epub 2022 Apr 28.

Department of Pediatrics, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China.

Aim: We sought to identify the clinical characteristics and risk factors for cardiac mortality in pediatric patients with primary dilated cardiomyopathy (DCM) in China.

Methods: A total of 138 pediatric patients who were consecutively diagnosed with primary DCM from January 2011 to December 2020 were included. We assessed patients' clinical symptoms and performed laboratory examinations, electrocardiography, and echocardiography. Read More

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Anesthetic management of heart and lung transplantation: analysis of 14 cases in a single center.

J Thorac Dis 2022 Apr;14(4):1099-1105

Department of Cardiac Surgery, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.

Background: Aggressive management of heart and lung transplant (HLTx) requires a team of specialists with dedicated expert to improve long-term outcomes. This study aimed to summarize practical experiences of anesthetic management in HLTx operations.

Methods: This study retrospectively analyzed the anesthesia-related clinical records of 14 cases of HLTx performed from September 2015 to October 2019. Read More

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Exploring Key Genes to Construct a Diagnosis Model of Dilated Cardiomyopathy.

Front Cardiovasc Med 2022 27;9:865096. Epub 2022 Apr 27.

Department of Cardiovascular Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

Background: Dilated cardiomyopathy (DCM) is characterized by left ventricular dilatation and systolic dysfunction. The pathogenesis and etiologies of DCM remain elusive. This study aims to identify the key genes to construct a genetic diagnosis model of DCM. Read More

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Efficacy and Safety of Qili Qiangxin Capsule on Dilated Cardiomyopathy: A Systematic Review and Meta-Analysis of 35 Randomized Controlled Trials.

Front Pharmacol 2022 28;13:893602. Epub 2022 Apr 28.

First Affiliated Hospital of Henan University of CM, Zhengzhou, China.

Qili Qiangxin Capsule (QQC), a Chinese patent medicine, is clinically effective in treating dilated cardiomyopathy (DCM). However, the meta-analysis of QCC combined with conventional western medicine (CWM) on DCM remains unexplored. This study aimed to systematically evaluate the efficacy and safety of QCC in the treatment of DCM. Read More

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Establishment of a human iPSC (ZZUNEUi026-A) from a dilated cardiomyopathy patient carrying heterozygous Vinculin (c. 625A > T) mutant.

Stem Cell Res 2022 May 10;62:102812. Epub 2022 May 10.

Department of Cardiology, Hami Central Hospital, Hami, Xinjiang 839000, China. Electronic address:

Dilated cardiomyopathy (DCM) is defined by left ventricular (or biventricular dilation) and systolic dysfunction, which eventually develops into congestive heart failure and arrhythmia. Vinculin is a membrane-associated protein, which functions to transmit contractile force. Defects in vinculin have been reported to be associated with DCM and hypertrophic cardiomyopathy. Read More

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Dilated-Left Ventricular Non-Compaction Cardiomyopathy in a Pediatric Case with Compound Heterozygous Variants.

Int J Mol Sci 2022 May 6;23(9). Epub 2022 May 6.

Aix Marseille University, INSERM, Marseille Medical Genetics, U1251 Marseille, France.

Left Ventricular Non-Compaction (LVNC) is defined by the triad prominent myocardial trabecular meshwork, thin compacted layer, and deep intertrabecular recesses. LVNC associated with dilation is characterized by the coexistence of left ventricular dilation and systolic dysfunction. Pediatric cases with dilated-LVNC have worse outcomes than those with isolated dilated cardiomyopathy and adult patients. Read More

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Whole-exome sequencing establishes a diagnosis of Alstrom syndrome: a case report.

Transl Pediatr 2022 Apr;11(4):589-594

Department of Endocrinology, Children's Hospital Capital Institute of Pediatrics, Beijing, China.

Background: Alstrom syndrome (ALMS) is a rare genetic disorder. ALMS is characterized by progressive bilateral sensorineural hearing impairment, cone-rod dystrophy, infantile-onset cardiomyopathy, hypertriglyceridemia, accelerated non-alcoholic fatty liver disease, renal dysfunction and insulin-resistant diabetes mellitus (DM). DM typically develop in childhood or adolescence. Read More

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A rare cause of dilated cardiomyopathy: hypocalcemia.

Arch Endocrinol Metab 2022 May 12. Epub 2022 May 12.

Istanbul University, Istanbul Faculty of Medicine, Department of Endocrinology and Metabolism, Istanbul, Turkey.

Dilated cardiomyopathy (DCM) is characterized by systolic dysfunction and is usually idiopathic. A rare cause of reversible DCM is hypocalcemia. Calcium plays a key role in myocardial contraction. Read More

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Dilated cardiomyopathy as the initial presentation of Becker muscular dystrophy: a systematic review of published cases.

Orphanet J Rare Dis 2022 05 12;17(1):194. Epub 2022 May 12.

Division of Cardiology, Texas Tech University Health Sciences Center, Lubbock, TX, 79430, USA.

There are scarce publications regarding the presentation and outcome of Becker muscular dystrophy in adulthood when idiopathic dilated cardiomyopathy is the initial disease manifestation. We performed a systematic review using Medline, Embase, Cochrane, and Scopus to identify cases of adults with idiopathic dilated cardiomyopathy who were subsequently diagnosed with Becker muscular dystrophy from inception through August 2020. Six cases were found. Read More

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Pregnancy in women with dilated cardiomyopathy.

Future Cardiol 2022 May 13. Epub 2022 May 13.

Penn State Milton S Hershey Medical Center, Hershey, PA 17033, USA.

Only a few studies describe the pathophysiology and outcomes of dilated cardiomyopathy (DCM) in pregnancy, which the authors aim to review here. DCM causes enlargement of the ventricles and reduced systolic function. Fluid overload and raised cardiac output in pregnancy may contribute to cardiac complications that lead to cardiac remodeling and heart failure, a common cause of maternal mortality. Read More

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Genetic Basis of Left Ventricular Noncompaction.

Circ Genom Precis Med 2022 May 12:101161CIRCGEN121003517. Epub 2022 May 12.

Division of Pediatric Cardiology, Department of Pediatrics, NYU Grossman School of Medicine, NY. (P.R., L.N., S.P., C.K.L.P.).

Background: Left ventricular noncompaction (LVNC) is the third most common pediatric cardiomyopathy characterized by a thinned myocardium and prominent trabeculations. Next-generation genetic testing has led to a rapid increase in the number of genes reported to be associated with LVNC, but we still have little understanding of its pathogenesis. We sought to grade the strength of the gene-disease relationship for all genes reported to be associated with LVNC and identify molecular pathways that could be implicated. Read More

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