630 results match your criteria Cardiology research and practice[Journal]


Heparin-Binding Protein: A Novel Biomarker Linking Four Different Cardiovascular Diseases.

Cardiol Res Pract 2020 15;2020:9575373. Epub 2020 Jun 15.

Department of Pediatrics, The Third Xiangya Hospital, Central South University, Hunan, Changsha, China.

Cardiovascular diseases are an important group of diseases that seriously affect quality of life. Thus, their treatment warrants further study. Heparin-binding protein (HBP) is a granulocyte protein derived from neutrophils. Read More

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http://dx.doi.org/10.1155/2020/9575373DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7312699PMC

Purkinje Fibers in Canine False Tendons: New Anatomical and Electrophysiological Findings.

Cardiol Res Pract 2020 15;2020:8156928. Epub 2020 Jun 15.

Department of Cardiology, General Hospital of Northern Theater Command, Shenyang 110840, China.

Introduction: Purkinje system and false tendons (FTs) are related to ventricular arrhythmia, but the association between Purkinje fibers and FTs is not clear. This study investigated the associations of anatomical and electrophysiological characteristics between Purkinje fibers and FTs.

Methods And Results: We optimized the protocol of Lugol's iodine solution staining of Purkinje fibers to study the anatomical structure and originated a novel electrophysiological mapping method, named the direct visual mapping (DVM) method, to study the electrophysiological characteristics. Read More

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http://dx.doi.org/10.1155/2020/8156928DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7312736PMC

Aliskiren Improved the Endothelial Repair Capacity of Endothelial Progenitor Cells from Patients with Hypertension via the Tie2/PI3k/Akt/eNOS Signalling Pathway.

Cardiol Res Pract 2020 28;2020:6534512. Epub 2020 May 28.

Department of Cardiovascular, The Third Affiliated Hospital, Sun Yat-Sen University, 600 TianHe Road, Guangzhou 510000, China.

Background: Studies show that aliskiren exerts favourable effects not only on endothelial progenitor cells (EPCs) but also on endothelial function. However, the mechanism of the favourable effect of aliskiren on EPCs from patients with hypertension is unclear and remains to be further studied.

Methods: The object of this study was to investigate and assess the in vitro function of EPCs pretreated with aliskiren. Read More

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http://dx.doi.org/10.1155/2020/6534512DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7275222PMC

Influence of Artery Straightening on Local Hemodynamics in Left Anterior Descending (LAD) Artery after Stent Implantation.

Cardiol Res Pract 2020 22;2020:6970817. Epub 2020 May 22.

Key Laboratory for Biomechanics and Mechanobiology of the Ministry of Education, School of Biological Science and Medical Engineering, Beijing Advanced Innovation Center for Biomedical Engineering, Beihang University, Beijing 100083, China.

Objectives: The study investigates local hemodynamic environment changes caused by straightening phenomenon and the relationship between straightening phenomenon and in-stent restenosis.

Background: Intravascular intervention is an effective treatment in restoring the normal flow conditions and vascular lumen. Unfortunately, in-stent restenosis often occurs in a subset of patients after stent implantation and limits the success of stent implantation outcomes. Read More

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http://dx.doi.org/10.1155/2020/6970817DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7261340PMC

Expiratory Flow Limitation at Different Exercise Intensities in Coronary Artery Disease.

Cardiol Res Pract 2020 21;2020:4629548. Epub 2020 May 21.

Department of Physical Therapy, Cardiovascular Physiotherapy Laboratory, Nucleus of Research in Physical Exercise, Federal University of São Carlos, São Carlos, São Paulo, Brazil.

Introduction: Expiratory flow limitation (EFL) during moderate intensity exercise is present in patients with myocardial infarction (MI), whereas in healthy subjects it occurs only at a high intensity. However, it is unclear whether this limitation already manifests in those with stable coronary artery disease (CAD) (without MI).

Materials And Methods: Forty-one men aged 40-65 years were allocated into (1) recent MI (RMI) group ( = 8), (2) late MI (LMI) group ( = 12), (3) stable CAD group ( = 9), and (4) healthy control group (CG) ( = 12). Read More

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http://dx.doi.org/10.1155/2020/4629548DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7260653PMC

Myocardial Fluid Balance and Pathophysiology of Myocardial Edema in Coronary Artery Bypass Grafting.

Cardiol Res Pract 2020 20;2020:3979630. Epub 2020 May 20.

Badau Bergerak Hospital, Kapuas Hulu, West Kalimantan, Indonesia.

Myocardial edema is one of the most common complications of coronary artery bypass grafting (CABG) that is linearly related to many coronary artery diseases. Myocardial edema can cause several consequences including systolic dysfunction, diastolic dysfunction, arrhythmia, and cardiac tissue fibrosis that can increase mortality in CABG. Understanding myocardial fluid balance and tissue and systemic fluid regulation is crucial in order to ultimately link how coronary artery bypass grafting can cause myocardial edema in such a setting. Read More

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http://dx.doi.org/10.1155/2020/3979630DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7256715PMC

The Prevalence of Cardiovascular Risk Factors among Polish Soldiers: The Results from the MIL-SCORE Program.

Cardiol Res Pract 2020 18;2020:3973526. Epub 2020 May 18.

Department of Cardiology and Internal Medicine, Military Institute of Medicine, Warsaw, Poland.

The MIL-SCORE (Equalization of Accessibility to Cardiology Prophylaxis and Care for Professional Soldiers) program was designed to assess the prevalence and management of cardiovascular risk factors in a population of Polish soldiers. We aimed to describe the prevalence of cardiovascular risk factors in the MIL-SCORE population with respect to age. This observational cross-sectional study enrolled 6440 soldiers (97% male) who underwent a medical history, physical examination, and laboratory tests to assess cardiovascular risk. Read More

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http://dx.doi.org/10.1155/2020/3973526DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7251455PMC

Smoking-Induced Inhibition of Number and Activity of Endothelial Progenitor Cells and Nitric Oxide in Males Were Reversed by Estradiol in Premenopausal Females.

Cardiol Res Pract 2020 12;2020:9352518. Epub 2020 May 12.

Division of Emergency Medicine, Department of Emergency Intensive Care Unit, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510080, China.

Objectives: The number and activity of circulating EPCs were enhanced in premenopausal women contrast to postmenopausal females and age-matched males. Here, we investigated whether this favorable effect exists in premenopausal women and age-matched men with cigarette smoking.

Methods: In a cross-sectional study, the number and activity of circulating EPCs and nitric oxide production (NO) as well as flow-mediated vasodilation (FMD) in both premenopausal women and age-matched men with or without cigarette smoking were studied. Read More

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http://dx.doi.org/10.1155/2020/9352518DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7240658PMC

Correlation between Galectin-3 and Adverse Outcomes in Myocardial Infarction Patients: A Meta-Analysis.

Cardiol Res Pract 2020 7;2020:7614327. Epub 2020 May 7.

Department of Cardiology, Shanghai Ninth People's Hospital, School of Medicine, Shanghai Jiaotong University, 639 Zhizaoju Road, Shanghai, China.

Background: Acute myocardial infarction (AMI) is a disease with high morbidity and mortality. Some new biomarkers can help us to improve the life quality and prognosis of AMI patients.

Objective: We therefore performed a systematic review and meta-analysis on the use of galectin-3 (gal3) for assessing prognosis of AMI patients. Read More

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http://dx.doi.org/10.1155/2020/7614327DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7229552PMC

Sex Differences in the Outcomes of Elderly Patients with Acute Coronary Syndrome.

Cardiol Res Pract 2020 12;2020:5091490. Epub 2020 May 12.

Department of Cardiology, The Second Xiangya Hospital of Central South University, Changsha, China.

Background: The impact of sex on the outcome of patients with acute coronary syndrome (ACS) has been suggested, but little is known about its impact on elderly patients with ACS.

Methods: This study analyzed the impact of sex on in-hospital and 1-year outcomes of elderly (≥75 years of age) patients with ACS hospitalized in our department between January 2013 and December 2017.

Results: A total of 711 patients were included: 273 (38. Read More

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http://dx.doi.org/10.1155/2020/5091490DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7240792PMC

Factors Associated with Prehospital Delay among Men and Women Newly Experiencing Acute Coronary Syndrome: A Qualitative Inquiry.

Cardiol Res Pract 2020 11;2020:3916361. Epub 2020 May 11.

Nursing Faculty, Mutah University, Karak, Jordan.

Background: Delaying seeking health care for patients with acute coronary syndrome (ACS) causes high mortality and morbidity with variations among men and women regarding reasons for this delay.

Objectives: This study explored factors associated with prehospital delay among men and women experiencing acute coronary syndrome for the first time in Jordan.

Methods: 35 men and 33 women with ACS admitted and treated at the coronary and postcoronary care units. Read More

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http://dx.doi.org/10.1155/2020/3916361DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7242810PMC

Decreased Mortality with Beta-Blocker Therapy in HFpEF Patients Associated with Atrial Fibrillation.

Cardiol Res Pract 2020 13;2020:3059864. Epub 2020 May 13.

Department of Cardiology, Shunde Hospital, Southern Medical University (The First People's Hospital of Shunde), Foshan, China.

Background: There are no proven effective treatments that can reduce the mortality in heart failure with preserved ejection fraction (HFpEF), probably due to its heterogeneous nature which will weaken the effect of therapy in clinical studies. We evaluated the effect of beta-blocker treatment in HFpEF patients associated with atrial fibrillation (AF), which is a homogeneous syndrome and has seldom been discussed.

Methods: This retrospective cohort study screened 955 patients diagnosed with AF and HFpEF. Read More

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http://dx.doi.org/10.1155/2020/3059864DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7243006PMC

Alzheimer's Disease and Cardiovascular Disease: A Particular Association.

Cardiol Res Pract 2020 5;2020:2617970. Epub 2020 May 5.

Department of Internal Medicine (DIMI) Clinic of Cardiovascular Diseases, University of Genoa, Genoa, Italy.

Methods: This review is based on the material obtained via MEDLINE (PubMed), EMBASE, and Clinical Trials databases, from January 1980 until May 2019. The search term used was "Alzheimer's disease," combined with "cardiovascular disease," "hypertension," "dyslipidaemia," "diabetes mellitus," "atrial fibrillation," "coronary artery disease," "heart valve disease," and "heart failure." Out of the 1,328 papers initially retrieved, 431 duplicates and 216 records in languages other than English were removed. Read More

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http://dx.doi.org/10.1155/2020/2617970DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7222603PMC

Beta Blocker Therapy in Heart Failure Patients with Active Cocaine Use: A Systematic Review.

Cardiol Res Pract 2020 8;2020:1985379. Epub 2020 May 8.

Division of Cardiology, New York Medical College, Metropolitan Hospital Center, New York, NY 10029, USA.

Background: Cocaine use is associated with multiple cardiovascular complications including heart failure. The use of different types of beta blockers in heart failure patients with active cocaine use is still a matter of debate. In this review, our objective is to systematically review the available literature regarding the use of beta blockers in the treatment of heart failure patients with concurrent cocaine use. Read More

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http://dx.doi.org/10.1155/2020/1985379DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7231080PMC

The Impact of Statins before High-Risk CABG on Postoperative Multiple Organ Function.

Cardiol Res Pract 2020 14;2020:9519736. Epub 2020 Jan 14.

Department of Cardiology, 12th Ward, Beijing Anzhen Hospital, Beijing Institute of Heart Lung and Blood Vessel Disease, Beijing Key Laboratory of Precision Medicine of Coronary Atherosclerotic Disease, Clinical Center for Coronary Heart Disease, Capital Medical University, Beijing 100029, China.

Background: The purpose of this cohort study was to investigate the independent relationship between preoperative statin therapy (PST) and postoperative severe multiorgan failure, measured by the Sequential Organ Failure Assessment (SOFA) maximum greater than 11, in high-risk patients undergoing isolated coronary artery bypass grafting (CABG).

Methods: The present study is a perspective, single-center, cohort analysis enrolling high-risk patients undergoing CABG from Jan 1, 2018, to Dec 31, 2018, in Beijing Anzhen hospital.

Results: Among a total of 880 high-risk patients undergoing isolated CABG included in this study, 503 (57. Read More

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http://dx.doi.org/10.1155/2020/9519736DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7201446PMC
January 2020

Plasma Choline as a Diagnostic Biomarker in Slow Coronary Flow.

Cardiol Res Pract 2020 25;2020:7361434. Epub 2020 Jan 25.

Department of Geriatric Medicine, Xiangya Hospital, Central South University, Changsha 410008, China.

Aim: The slow coronary flow (SCF) phenomenon was characterized by delayed perfusion of epicardial arteries, and no obvious coronary artery lesion in coronary angiography. The prognosis of patients with slow coronary flow was poor. However, there is lack of rapid, simple, and accurate method for SCF diagnosis. Read More

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http://dx.doi.org/10.1155/2020/7361434DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7204336PMC
January 2020

Serum VEGF: Diagnostic Value of Acute Coronary Syndrome from Stable Angina Pectoris and Prognostic Value of Coronary Artery Disease.

Cardiol Res Pract 2020 10;2020:6786302. Epub 2020 Jan 10.

Nankai University School of Medicine, Tianjin 300071, China.

Background: Although the level of serum vascular endothelial growth factor (VEGF) is elevated in coronary artery disease (CAD) patients, its potential role in acute coronary syndrome (ACS) or stable angina pectoris (SAP) patients remains unclear.

Objectives: To evaluate diagnostic accuracy of serum VEGF in determining ACS patients from SAP and analyze the association of serum VEGF with coronary artery lesions in SAP or the GRACE score in ACS, which is involved in the poor prognosis of low serum VEGF.

Methods: 248 CAD patients and 48 healthy subjects were enrolled in this study. Read More

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http://dx.doi.org/10.1155/2020/6786302DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7199618PMC
January 2020

Therapeutic Efficacy of Alpha-Lipoic Acid against Acute Myocardial Infarction and Chronic Left Ventricular Remodeling in Mice.

Cardiol Res Pract 2020 7;2020:6759808. Epub 2020 Jan 7.

Department of Biomedical Engineering, University of Virginia Health System, Charlottesville, VA 22908, USA.

Background: We hypothesized that daily administration of a potent antioxidant (-lipoic acid: ALA) would protect the heart against both acute myocardial infarction (AMI) and left ventricular remodeling (LVR) post-AMI.

Methods And Results: Two separate studies were conducted. In the AMI study, C57Bl/6 mice were fed ALA daily for 7 d prior to a 45-minute occlusion of the left coronary artery (LCA). Read More

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http://dx.doi.org/10.1155/2020/6759808DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7199633PMC
January 2020

The Hemodynamic Effect of Enhanced External Counterpulsation Treatment on Atherosclerotic Plaque in the Carotid Artery: A Framework of Patient-Specific Computational Fluid Dynamics Analysis.

Cardiol Res Pract 2020 30;2020:5903790. Epub 2020 Apr 30.

Laboratory for Engineering and Scientific Computing, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China.

Long-term enhanced external counterpulsation (EECP) therapy has been recommended for antiatherogenesis in recent clinical observations and trials. However, the precise mechanism underlying the benefits has not been fully clarified. To quantify the effect of EECP intervention on arterial hemodynamic environment, a framework of numerical assessment was introduced using a parallel computing algorithm. Read More

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http://dx.doi.org/10.1155/2020/5903790DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7210552PMC

The Nrf-2/HO-1 Signaling Axis: A Ray of Hope in Cardiovascular Diseases.

Cardiol Res Pract 2020 30;2020:5695723. Epub 2020 Jan 30.

Department of Pediatrics, The Third Xiangya Hospital, Central South University, Hunan Province, Changsha 410013, China.

Cardiovascular disease, which can lead to angina and shortness of breath, remains one of the most serious threats to human health. Owing to its imperceptible symptoms, it is difficult to determine the pathogenesis and treatment methods for cardiovascular disease. Nuclear factor erythropoietin-2-related factor 2/heme oxygenase 1 (Nrf2/HO-1) is a protein found in all cells of the human body. Read More

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http://dx.doi.org/10.1155/2020/5695723DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7204387PMC
January 2020

Pathophysiological and Genetic Aspects of Vascular Calcification.

Cardiol Res Pract 2020 14;2020:5169069. Epub 2020 Apr 14.

Heart Institute (InCor), University of São Paulo Medical School, São Paulo, Brazil.

Recent evidence suggests that vascular calcification is an independent cardiovascular risk factor (CRF) of morbidity and mortality. New studies point out the existence of a complex physiopathological mechanism that involves inflammation, oxidation, the release of chemical mediators, and genetic factors that promote the osteochondrogenic differentiation of vascular smooth muscle cells (VSMC). This review will evaluate the main mechanisms involved in the pathophysiology and genetics modulation of the process of vascular calcification. Read More

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http://dx.doi.org/10.1155/2020/5169069DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7201852PMC

Low Expression of in Peripheral White Blood Cells May Be a Genetic Marker for Early Diagnosis of Acute Myocardial Infarction.

Cardiol Res Pract 2020 25;2020:3108124. Epub 2020 Jan 25.

Jilin Provincial Precision Medicine Key Laboratory for Cardiovascular Genetic Diagnosis (Jilin Provincial Engineering Laboratory for Endothelial Function and Genetic Diagnosis of Cardiovascular Disease Jilin Provincial Molecular Biology Research Center for Precision Medicine of Major Cardiovascular Disease Jilin Provincial Cardiovascular Research Institute), Department of Cardiology, China-Japan Union Hospital of Jilin University, Changchun 130033, China.

Objective: To find molecular markers for the diagnosis of acute myocardial infarction (AMI), this research further verified the relationship between the expression level of gene and AMI by expanding the sample size based on the previous gene chip results.

Methods: Peripheral venous leukocytes were collected from 113 patients with AMI and 94 patients with noncoronary artery disease as the experimental group and the control group, respectively. Real-time fluorescence quantitative polymerase chain reaction was used to detect the expression of the gene. Read More

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http://dx.doi.org/10.1155/2020/3108124DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7204345PMC
January 2020

Clinical Characteristics and Factors Associated with Heart Failure Readmission at a Tertiary Hospital in North-Eastern Tanzania.

Cardiol Res Pract 2020 30;2020:2562593. Epub 2020 Apr 30.

Department of Internal Medicine, Kilimanjaro Christian Medical University College, Moshi, Tanzania.

Introduction: Heart failure (HF) is characterized by frequent episodes of decompensation, leading to a high hospitalization burden. More than 50% of index hospitalizations for HF patients return within 6 months of discharge. Once the patient is readmitted, the risk of further disease progression and the mortality rate are increased. Read More

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http://dx.doi.org/10.1155/2020/2562593DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7210553PMC

Reduced Circulating Endothelial Progenitor Cells and Downregulated GTCPH I Pathway Related to Endothelial Dysfunction in Premenopausal Women with Isolated Impaired Glucose Tolerance.

Cardiol Res Pract 2020 25;2020:1278465. Epub 2020 Jan 25.

Department of Ultrasound, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, China.

Background: Individuals at a prediabetic stage have had an augmented cardiovascular disease (CVD) risk and CVD-related mortality compared to normal glucose tolerance (NGT) individuals, which may be attributed to the impaired vascular endothelial repair capacity. In this study, circulating endothelial progenitor cells' (EPCs) number and activity were evaluated, and the underlying mechanisms in premenopausal women with impaired glucose regulation were explored.

Methods: Circulating EPCs' number and activity and flow-mediated dilation (FMD) were compared in premenopausal women with NGT, isolated impaired fasting glucose (i-IFG), or isolated impaired glucose tolerance (i-IGT). Read More

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http://dx.doi.org/10.1155/2020/1278465DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7204339PMC
January 2020

Combination of Left Ventricular End-Diastolic Diameter and QRS Duration Strongly Predicts Good Response to and Prognosis of Cardiac Resynchronization Therapy.

Cardiol Res Pract 2020 17;2020:1257578. Epub 2020 Jan 17.

Institute of Cardiovascular Diseases, Xinqiao Hospital, Army Medical University (Third Military Medical University), 183 Xinqiao Street, Chongqing 400037, China.

Background: Approximately 20-40% of recipients of cardiac resynchronization therapy (CRT) do not respond to it based on the current patient selection criteria. The purpose of this study was to identify baseline parameters that can predict CRT response and to evaluate the effect of those predictive parameters on long-term prognosis.

Methods: This was a retrospective, nonrandomized, noncontrolled cohort study. Read More

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http://dx.doi.org/10.1155/2020/1257578DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7201746PMC
January 2020

Functional Genetic Variant in ATG5 Gene Promoter in Acute Myocardial Infarction.

Cardiol Res Pract 2020 21;2020:9898301. Epub 2020 Apr 21.

Shandong Provincial Key Laboratory of Cardiac Disease Diagnosis and Treatment, Affiliated Hospital of Jining Medical University, Jining Medical University, Jining, Shandong 272029, China.

Coronary artery disease (CAD) including acute myocardial infarction (AMI) is an inflammatory and metabolic disease mainly caused by atherosclerosis. Dysfunctional autophagy has been associated with abnormal lipid metabolism and inflammation. In previous studies, we have reported altered autophagic activity in AMI patients. Read More

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http://dx.doi.org/10.1155/2020/9898301DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7191428PMC

Change in Atrial Fibrillation Burden over Time in Patients with Nonpermanent Atrial Fibrillation.

Cardiol Res Pract 2020 17;2020:9583409. Epub 2020 Apr 17.

Cardiovascular Research Institute Basel, University Hospital Basel, Basel, Switzerland.

Introduction: The natural course of atrial fibrillation (AF) is not well defined. We aimed to investigate the change in AF burden over time and its associated risk factors among AF patients.

Methods: Fifty-four participants with recently documented paroxysmal or persistent AF were enrolled. Read More

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http://dx.doi.org/10.1155/2020/9583409DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7183533PMC

Profile of Endothelin-1, Nitric Oxide, and Prostacyclin Levels in Pulmonary Arterial Hypertension Related to Uncorrected Atrial Septal Defect: Results from a Single Center Study in Indonesia.

Cardiol Res Pract 2020 7;2020:7526508. Epub 2020 Jan 7.

Department of Cardiology and Vascular Medicine, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada-Dr. Sardjito Hospital, Yogyakarta, Indonesia.

Methods: The study design was cross-sectional. The subjects were adult uncorrected secundum ASD with PAH. Pulmonary artery pressure was measured with right heart catheterization. Read More

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http://dx.doi.org/10.1155/2020/7526508DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7199565PMC
January 2020

Elevated GTP Cyclohydrolase I Pathway in Endothelial Progenitor Cells of Overweight Premenopausal Women.

Cardiol Res Pract 2020 7;2020:5914916. Epub 2020 Jan 7.

Department of Emergency Medicine, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China.

/. Sexual differences exist in endothelial progenitor cells (EPCs), and various cardiovascular risk factors are associated with the preservation of endothelial function in premenopausal women. However, it is unclear whether differences in endothelial function and circulating EPCs exist between overweight premenopausal women and age-matched men. Read More

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http://dx.doi.org/10.1155/2020/5914916DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7199531PMC
January 2020

Macrophage Activities in Myocardial Infarction and Heart Failure.

Cardiol Res Pract 2020 22;2020:4375127. Epub 2020 Apr 22.

First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China.

Heart diseases remain the major cause of death worldwide. Advances in pharmacological and biomedical management have resulted in an increasing proportion of patients surviving acute heart failure (HF). However, many survivors of HF in the early stages end up increasing the disease to chronic HF (CHF). Read More

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http://dx.doi.org/10.1155/2020/4375127DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7193281PMC

Urine-Derived Induced Pluripotent Stem Cells in Cardiovascular Disease.

Cardiol Res Pract 2020 10;2020:3563519. Epub 2020 Jan 10.

Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong 510100, China.

Recent studies have demonstrated that stem cells are equipped with the potential to differentiate into various types of cells, including cardiomyocytes. Meanwhile, stem cells are highly promising in curing cardiovascular diseases. However, owing to the ethical challenges posed in stem cell acquisition and the complexity and invasive nature of the method, large-scale expansions and clinical applications in the laboratory have been limited. Read More

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http://dx.doi.org/10.1155/2020/3563519DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7199581PMC
January 2020

Diagnostic Role of Plasma MicroRNA-21 in Stable and Unstable Angina Patients and Association with Aging.

Cardiol Res Pract 2020 13;2020:9093151. Epub 2020 Apr 13.

Department of Internal Medicine, Cardiology, College of Medicine, Jouf University, Sakaka, Aljouf, Saudi Arabia.

The present study explored the clinical value of plasma microRNA-21 as a novel biomarker for early prediction of stable and unstable angina patients and its relationship with aging. A total of 255 participants, 123 patients with chronic stable angina, 82 patients with unstable angina, and 50 healthy subjects, were included in our study. Stable coronary and unstable coronary patients were confirmed following AHA/ACC clinical protocols. Read More

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http://dx.doi.org/10.1155/2020/9093151DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7174930PMC

Cryoablation Combined with Left Atrial Appendage Closure: A Safe and Effective Procedure for Paroxysmal Atrial Fibrillation Patients.

Cardiol Res Pract 2020 10;2020:6573296. Epub 2020 Apr 10.

Department of Cardiology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.

Background: Catheter ablation combined with left atrial appendage closure (LAAC) was reported as a feasible strategy for atrial fibrillation (AF) patients with high risk of stroke or contraindications of oral anticoagulants. We aimed to observe the short-term safety and efficacy of combining cryoballoon ablation (CBA) with LAAC in paroxysmal (PAF) patients. . Read More

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http://dx.doi.org/10.1155/2020/6573296DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7171640PMC

Effect of Combined Antihypertensive and Lipid-Lowering Therapies on Cognitive Function: A New Treatment Strategy?

Authors:
Ze-Min Kuang

Cardiol Res Pract 2020 14;2020:1484357. Epub 2020 Apr 14.

Department of Hypertension, Beijing Anzhen Hospital of Capital Medical University, Beijing 100029, China.

Risk factors for cardiovascular disease such as hypertension and hyperlipidemia are associated with cognitive decline. However, there is still no clear evidence that the use of antihypertensive or lipid-lowering therapy can prevent or delay cognitive decline or development of dementia. To provide a reference for clinical treatment, we analyzed the potential mechanisms of cognitive dysfunction induced by hypertension and hyperlipidemia, the clinical research and controversy of antihypertensive and lipid-lowering therapies on cognitive function, and the clinical value of combined antihypertensive and lipid-lowering therapy. Read More

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http://dx.doi.org/10.1155/2020/1484357DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7178519PMC

Translation and Validation of the Arrhythmia-Specific Questionnaire in Tachycardia and Arrhythmia (ASTA) to the Brazilian Context: An Instrument Focusing on Arrhythmia Symptoms.

Cardiol Res Pract 2020 10;2020:1402916. Epub 2020 Apr 10.

School of Nursing, University of Campinas, Campinas 13083-970, Brazil.

Introduction: The wide variety of symptoms in patients with cardiac arrhythmias can affect daily living activities. The evaluation of symptoms with patient-reported outcome measures (PROMs), with validated instruments, can provide information that contributes to clinical decisions and treatment. In Brazil, however, there is no available scale that evaluates symptoms in different types of arrhythmias. Read More

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http://dx.doi.org/10.1155/2020/1402916DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7171627PMC

Serum N-Acetylneuraminic Acid Is Associated with Atrial Fibrillation and Left Atrial Enlargement.

Cardiol Res Pract 2020 13;2020:1358098. Epub 2020 Apr 13.

Department of Cardiology, Renmin Hospital of Wuhan University, Cardiovascular Research Institute, Wuhan University, Hubei Key Laboratory of Cardiology, Wuhan, Hubei 430060, China.

Purpose: Recent studies have indicated that N-acetylneuraminic acid (Neu5Ac) plays a key role in severe coronary artery diseases, involving RhoA signaling pathway activation, which is critically involved in cardiac fibrosis. There is convincing evidence from many studies that left atrium fibrosis is involved in the pathophysiology of AF. Therefore, we speculated that Neu5Ac may be associated with atrial fibrillation (AF) and involved in the development of AF. Read More

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http://dx.doi.org/10.1155/2020/1358098DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7174944PMC

Mixture of MMP-2, MLC, and NOS Inhibitors Affects NO Metabolism and Protects Heart from Cardiac I/R Injury.

Cardiol Res Pract 2020 7;2020:1561478. Epub 2020 Apr 7.

Department of Medical Laboratory Diagnostics, Division of Clinical Chemistry and Laboratory Hematology, Wroclaw Medical University, Wroclaw, Poland.

Objectives: Coronary reperfusion procedure leads to ischemia/reperfusion injury of the heart (IRI). IRI arises from increased degradation of myosin light chains and increased activity of matrix metalloproteinase 2 (MMP-2). Increased production of toxic peroxynitrite (ONOO) during oxidative stress is a source of increased nitration/nitrosylation of contractile proteins, which enhance their degradation through MMP-2. Read More

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http://dx.doi.org/10.1155/2020/1561478DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7166281PMC

Conversion from Nonshockable to Shockable Rhythms and Out-of-Hospital Cardiac Arrest Outcomes by Initial Heart Rhythm and Rhythm Conversion Time.

Cardiol Res Pract 2020 28;2020:3786408. Epub 2020 Mar 28.

Department of Emergency Medicine, University of Texas, Southwestern Medical Center, Dallas, TX, USA.

Background: The conversion from a nonshockable rhythm (asystole or pulseless electrical activity (PEA)) to a shockable rhythm (pulseless ventricular tachycardia or ventricular fibrillation) may be associated with better out-of-hospital cardiac arrest (OHCA) outcomes. There are insufficient data on the prognostic significance of such conversions by initial heart rhythm and different rhythm conversion time.

Methods: Among 24,849 adult OHCA patients of presumed cardiac etiology with initial asystole or PEA in the Resuscitation Outcomes Consortium Cardiac Epidemiologic Registry (version 3, 2011-2015), we examined the association of shockable rhythm conversion with prehospital return of spontaneous circulation (ROSC), survival, and favorable functional outcome (modified Rankin Scale score ≤3) at hospital discharge by initial rhythm and rhythm conversion time (time from cardiopulmonary resuscitation (CPR) initiation by emergency medical providers to first shock delivery), using logistic regression adjusting for key clinical characteristics. Read More

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http://dx.doi.org/10.1155/2020/3786408DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7142338PMC

Omentin-1 Ameliorated Free Fatty Acid-Induced Impairment in Proliferation, Migration, and Inflammatory States of HUVECs.

Cardiol Res Pract 2020 27;2020:3054379. Epub 2020 Mar 27.

Department of Cardiac Surgery, Xiangya Hospital, Central South University, Changsha 410008, Hunan, China.

Objectives: Endothelial cell injury is a critical pathological change during the development of atherosclerosis. Here, we explored the effect of omentin-1 on free fatty acid- (FFA-) induced endothelial cell injury.

Methods: An FFA-induced endothelial cell injury model was established to investigate the role of omentin-1 in this process. Read More

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http://dx.doi.org/10.1155/2020/3054379DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7140148PMC

Haemodynamic Effects of Anaemia in Patients with Acute Decompensated Heart Failure.

Cardiol Res Pract 2020 21;2020:9371967. Epub 2020 Mar 21.

Department of Cardiology and Internal Diseases, Military Institute of Medicine, Szaserów Street 128, 04-141 Warsaw, Poland.

Anaemia is a common comorbidity in patients with heart failure (HF) and is associated with more severe symptoms and increased mortality. The aim of this study was to evaluate haemodynamic profiles of HF patients with respect to the presence of reduced left ventricular ejection fraction (LVEF) and anaemia. . Read More

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http://dx.doi.org/10.1155/2020/9371967DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7115042PMC

Association between Alanine Aminotransferase/Aspartate Aminotransferase Ratio (AST/ALT Ratio) and Coronary Artery Injury in Children with Kawasaki Disease.

Cardiol Res Pract 2020 23;2020:8743548. Epub 2020 Mar 23.

Children's Heart Center, The Second Affiliated Hospital and Yuying Children's Hospital, Institute of Cardiovascular Development and Translational Medicine, Wenzhou Medical University, Wenzhou 325027, Zhejiang, China.

Objective: To investigate the association between the aspartate aminotransferase (AST)/alanine aminotransferase (ALT) ratio (AST/ALT ratio, AAR) and intravenous immunoglobulin (IVIG) resistance, coronary artery lesions (CAL), and coronary artery aneurysms (CAA) in children with Kawasaki disease (KD).

Design: We retrospectively studied 2678 children with KD and divided them into two groups: a low-AAR group and a high-AAR group with a median AAR of 1.13 as the cut-off point. Read More

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http://dx.doi.org/10.1155/2020/8743548DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7125506PMC

Left Atrial Strain as Evaluated by Two-Dimensional Speckle Tracking Predicts Left Atrial Appendage Dysfunction in Chinese Patients with Atrial Fibrillation.

Cardiol Res Pract 2020 21;2020:5867617. Epub 2020 Mar 21.

Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong 510100, China.

Left atrial appendage (LAA) dysfunction identified by transesophageal echocardiography (TEE) is a powerful predictor of stroke in patients with atrial fibrillation (AF). The aim of our study is to assess if there is a correlation between the left atrial (LA) functional parameter and LAA dysfunction in the AF patients. This cross-sectional study included a total of 249 Chinese AF patients who did not have cardiac valvular diseases and were undergoing cardiac ablation. Read More

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http://dx.doi.org/10.1155/2020/5867617DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7115138PMC

Reduced Albuminuria and Potassemia Indicate Early Renal Repair Processes after Resynchronization Therapy in Cardiorenal Syndrome Type 2.

Cardiol Res Pract 2020 21;2020:2727108. Epub 2020 Mar 21.

Medical College of Rzeszów University, Institute of Medical Sciences, Rzeszów 35-310, Poland.

Background: Patients with chronic cardiorenal syndrome type 2 (T2-CRS) who qualify for resynchronization therapy (CRT) are exposed perioperatively to potentially nephrotoxic factors including contrast agents and blood loss.

Methods: The objective of this prospective interventional study was to assess the effects of CRT on renal function in patients with T2-CRS within the first 48 hours following implantation. Initially, 76 patients (15% female; aged 69 ± 9. Read More

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http://dx.doi.org/10.1155/2020/2727108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7115056PMC

Impact of Cardiac Rehabilitation on Functional Capacity and Physical Activity after Coronary Revascularization: A Scientific Review.

Cardiol Res Pract 2020 21;2020:1236968. Epub 2020 Mar 21.

Department of Physiotherapy, Manipal College of Health Professions, Manipal Academy of Higher Education, Manipal, Karnataka 576104, India.

Background: Coronary revascularization procedures often cause lowered exercise capacity and declining physical activity levels. These outcomes are paramount in predicting morbidity and mortality after these procedures. Cardiac rehabilitation (CR) focuses on incrementing cardiovascular endurance, exercise capacity, muscle strength, levels of physical activity, and quality of life through health education and lifestyle modification in post-coronary revascularization patients. Read More

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http://dx.doi.org/10.1155/2020/1236968DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7115053PMC

The Role of IL-33 in Experimental Heart Transplantation.

Cardiol Res Pract 2020 19;2020:6108362. Epub 2020 Mar 19.

Department of Rheumatology and Clinical Immunology, Jiangxi Provincial People's Hospital Affiliated to Nanchang University, Nanchang, Jiangxi, China.

Interleukin-33 (IL-33) is a member of the IL-1 family of proteins that are produced by a variety of cell types in multiple tissues. Under conditions of cell injury or death, IL-33 is passively released from the nucleus and acts as an "alarmin" upon binding to its specific receptor ST2, which leads to proinflammatory or anti-inflammatory effects depending on the pathological environment. To date, numerous studies have investigated the roles of IL-33 in human and murine models of diseases of the nervous system, digestive system, pulmonary system, as well as other organs and systems, including solid organ transplantation. Read More

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http://dx.doi.org/10.1155/2020/6108362DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7106886PMC

Waist-to-Height Ratio (WHtR) in Predicting Coronary Artery Disease Compared to Body Mass Index and Waist Circumference in a Single Center from Saudi Arabia.

Cardiol Res Pract 2020 16;2020:4250793. Epub 2020 Mar 16.

College of Medicine, King Saud University, Riyadh, Saudi Arabia.

This study aims to study the efficiency of the Waist-to-Height Ratio (WHtR) for determining coronary artery disease. It compares the frequency of abnormal WHtR, as a proxy for abdominal obesity, to that of body mass index (BMI) and waist circumference (WC). It also relates the findings to other cardiometabolic risk factors in University Hospital patients. Read More

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http://dx.doi.org/10.1155/2020/4250793DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7102403PMC

Diagnostic Efficacy of Cardiac Scintigraphy with Tc-Pyrophosphate for Latent Myocardial Inflammation in Patients with Atrial Fibrillation.

Cardiol Res Pract 2020 16;2020:5983751. Epub 2020 Mar 16.

Cardiology Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, 111a Kievskaya Str., Tomsk 634012, Russia.

Objectives: This work aimed to study the efficacy of hybrid Tc-Pyrophosphate SPECT/CT for diagnosis of latent inflammatory processes in the myocardium of patients with atrial fibrillation (AF).

Methods: The study comprised 34 patients aged 44 ± 9 years with AF of unknown etiology referred for radiofrequency ablation. The data were acquired using hybrid Tc-Pyrophosphate SPECT/CT. Read More

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http://dx.doi.org/10.1155/2020/5983751DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7057002PMC

The Brain-Heart Connection in Takotsubo Syndrome: The Central Nervous System, Sympathetic Nervous System, and Catecholamine Overload.

Cardiol Res Pract 2020 9;2020:4150291. Epub 2020 Mar 9.

Department of Cardiovascular Medicine, The Second Xiangya Hospital, Central South University, Changsha, 139 Middle Renmin Road, Hu'nan 410011, China.

Takotsubo syndrome (TTS), also known as stress cardiomyopathy, is a type of acute heart failure syndrome triggered by intense psychological or physiological stress. TTS typically manifests as acute chest pain, dyspnea or syncope that mimics an acute myocardial infarction but does not involve coronary artery obstruction. The current understanding of the pathogenesis of TTS suggests that sympathetic nervous system (SNS) activation plays a central role. Read More

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http://dx.doi.org/10.1155/2020/4150291DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7085406PMC

Left Ventricular End Diastolic Volume and Ejection Fraction Calculation: Correlation between Three Echocardiographic Methods.

Cardiol Res Pract 2020 28;2020:8076582. Epub 2020 Feb 28.

Clinical Research Department, A. de Rothschild Foundation, Paris, France.

Background: Left ventricular ejection fraction (LVEF) and end diastolic volume (EDV) are measured using Simpson's biplane (SB), 3-dimensional method (3DE), and speckle tracking (STE). Comparisons between methods in routine practice are limited. Our purpose was to compare and to determine the correlations between these three methods in clinical setting. Read More

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http://dx.doi.org/10.1155/2020/8076582DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7064836PMC
February 2020

The Peroxisome Proliferator-Activated Receptor Agonist Pioglitazone Protects Vascular Endothelial Function in Hypercholesterolemic Rats by Inhibiting Myeloperoxidase.

Cardiol Res Pract 2020 7;2020:1845969. Epub 2020 Jan 7.

Beijing Key Laboratory of Metabolic Disorders Related Cardiovascular Diseases, Capital Medical University, Beijing 100069, China.

Objective: Hypercholesterolemia- (HC-) induced endothelial dysfunction is the first step of atherogenesis, and the peroxisome proliferator-activated receptor (PPAR (PPAR (PPAR) has been reported to attenuate atherosclerosis formation; however, the underlying mechanisms are not fully understood. The present study was designed to determine whether myeloperoxidase (MPO) mediates HC-induced endothelial dysfunction and the role of the PPAR agonist pioglitazone (PIO) in attenuating endothelial dysfunction.

Methods: Male Wistar rats were fed with normal or high cholesterol diets for 8 weeks. Read More

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http://dx.doi.org/10.1155/2020/1845969DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7063881PMC
January 2020