303,726 results match your criteria Cardiology journal[Journal]


Antithrombotic Medication and the Risk of Vitreous Hemorrhage in Atrial Fibrillation: Korean National Health Insurance Service National Cohort.

Yonsei Med J 2019 Jan;60(1):65-72

Division of Cardiology, Yonsei University College of Medicine, Seoul, Korea.

Purpose: Antithrombotic therapy could be related with nuisance bleeding. This study investigated whether vitreous hemorrhage (VH) is associated with specific types of antithrombotic medication in patients with atrial fibrillation (AF).

Materials And Methods: In the Korean National Health Insurance Service National Sample Cohort, we identified 9352 antiplatelet/anticoagulant-treated AF patients. Read More

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January 2019

Characterization of Flow Efficiency, Pulsatility, and Respiratory Variability in Different Types of Fontan Circuits Using Quantitative Parameters.

Yonsei Med J 2019 Jan;60(1):56-64

Division of Cardiovascular Surgery, Severance Cardiovascular Hospital, Yonsei University College of Medicine, Seoul, Korea.

Purpose: Details on the hemodynamic differences among Fontan operations remain unclear according to respiratory and cardiac cycles. This study was undertaken to investigate hemodynamic characteristics in different types of Fontan circulation by quantification of blood flow with the combined influence of cardiac and respiratory cycles.

Materials And Methods: Thirty-five patients [10 atriopulmonary connections (APC), 13 lateral tunnels (LT), and 12 extracardiac conduits (ECC)] were evaluated, and parameters were measured in the superior vena cava, inferior vena cava (IVC), hepatic vein (HV), baffles, conduits, and left and right pulmonary artery. Read More

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January 2019

Left Ventricular End-Systolic Volume Can Predict 1-Year Hierarchical Clinical Composite End Point in Patients with Cardiac Resynchronization Therapy.

Yonsei Med J 2019 Jan;60(1):48-55

Division of Cardiology, Department of Internal Medicine, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.

Purpose: This study aimed to elucidate which echocardiographic criteria at three time points, for cardiac resynchronization therapy (CRT) response, are accurate in discriminating the hierarchical clinical composite end point (HCCEP).

Materials And Methods: We included 120 patients (age, 66.1±12. Read More

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January 2019

Selective Activation of Cannabinoid Receptor 2 Attenuates Myocardial Infarction via Suppressing NLRP3 Inflammasome.

Inflammation 2018 Dec 15. Epub 2018 Dec 15.

Department of Cardiology, Zhejiang Hospital, 12 Lingyin Road, Zhejiang, Hangzhou, China.

The administration of cannabinoid receptor 2 (CB2R) agonist has been reported to produce a cardioprotective effect against the pathogenesis and progression of myocardial infarction (MI). Here in this study, we investigated the specific mechanism related to inflammatory suppression. JWH-133 was used for the activation of CB2R. Read More

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December 2018

Vascular responses to a Viabahn stent graft: evaluation with computed tomographic angiography, angiography, and angioscopy.

Cardiovasc Interv Ther 2018 Dec 15. Epub 2018 Dec 15.

Department of Cardiology, Hyogo Prefectural Amagasaki General Medical Center, 2-17-77 Higashinaniwa-cho, Amagasaki, 660-8550, Japan.

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December 2018

Idiopathic Pulmonary Fibrosis for Cardiologists: Differential Diagnosis, Cardiovascular Comorbidities, and Patient Management.

Adv Ther 2018 Dec 15. Epub 2018 Dec 15.

U.O. di Pneumologia e Terapia Semi-Intensiva Respiratoria - Servizio di Fisiopatologia Respiratoria ed Emodinamica Polmonare, Ospedale San Giuseppe - MultiMedica IRCCS, Milan, Italy.

The presence of rare comorbidities in patients with cardiovascular disease (CVD) presents a diagnostic challenge to cardiologists. In evaluating these patients, cardiologists are faced with a unique opportunity to shorten diagnosis times and direct patients towards correct treatment pathways. Idiopathic pulmonary fibrosis (IPF), a type of interstitial lung disease (ILD), is an example of a rare disease where patients frequently demonstrate comorbid CVD. Read More

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December 2018

Medical education reform in China.

Authors:
Hui Li Xiang Zhou

Postgrad Med J 2018 Dec 15. Epub 2018 Dec 15.

Department of Cardiology, The Second Affiliated Hospital of Soochow University, Suzhou, China

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December 2018

Atypical ischemic repolarization in right bundle branch block.

J Electrocardiol 2018 Dec 6;52:117-118. Epub 2018 Dec 6.

Department "A" Medical Area, Instituto Nacional de Cardiología Ignacio Chávez, Juan Badiano 1, Belisario Domínguez - Sección XVI, Tlalpan, Mexico City PO 14080, Mexico.

A 70-year-old male presented to emergency room 16 h after the onset of acute chest pain. Initial ECG showed sinus rhythm with a wide QRS and right bundle branch block (RBBB) with concordant and symmetric T waves in V1-V2. A plausible explanation for the atypical positive T waves in leads V1-V2 in conjunction with RBBB could be non-reperfused lateral MI (LMI) as a "mirror-image" of inverted T waves in the posterior leads V7-V9. Read More

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December 2018

Diurnal cardiac sympathetic hyperactivity after exposure to acute particulate matter 2.5 air pollution.

J Electrocardiol 2018 Nov 15;52:112-116. Epub 2018 Nov 15.

Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital. Taiwan; Institute of Clinical Medicine, Cardiovascular Research Institute, National Yang-Ming University, Taiwan.

Background: Ambient fine particulate matter (PM2.5) exposure is associated with increased cardiovascular and cardiac arrhythmias events, but the detailed mechanism remains unclear.

Objective: We aimed to investigate the effect of PM2. Read More

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November 2018

PERK is essential for proliferation of intestinal stem cells in mice.

Exp Cell Res 2018 Dec 14. Epub 2018 Dec 14.

Division of Emergency Medicine, Department of General Internal Medicine, Department of Emergency Intensive Care Unit, The First Affiliated Hospital of Sun Yat-sen University, No.58, Zhongshan 2nd Road, Guangzhou, 510080, China. Electronic address:

Protein kinase RNA-like Endoplasmic Reticulum Kinase (PERK) is an endoplasmic reticulum stress sensor that possesses pro-survival capability and contributes to cell homeostasis and survival. Leucine-rich repeat-containing G-protein coupled receptor 5 (Lgr5) has been recognized as a stem cell marker in intestinal epithelial cells. To determine whether PERK modulates the proliferation of intestinal stem cells, we investigated the effects of PERK knock-down on intestinal Lgr5-positive stem cells in mice. Read More

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December 2018

Incidence, Predictors, and Outcome Associations of Dyskalemia in Heart Failure With Preserved, Mid-Range, and Reduced Ejection Fraction.

JACC Heart Fail 2018 Dec 10. Epub 2018 Dec 10.

Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.

Objectives: This study investigated 1-year incidence and predictors of dyskalemia (dysK) and its outcome associations in heart failure with preserved ejection fraction (HFpEF), HF with mid-range EF (HFmrEF), and HF with reduced EF (HFrEF).

Background: DysK in real-world HF is insufficiently characterized. Fear of dyskalemia may lead to underuse or underdosing of renin-angiotensin-aldosterone system inhibitors. Read More

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December 2018

Heart Failure and Liver Disease: Cardiohepatic Interactions.

JACC Heart Fail 2018 Dec 7. Epub 2018 Dec 7.

Department of Cardiology, Larissa University General Hospital, Larissa, Greece. Electronic address:

Heart failure (HF) and liver disease often co-exist. This is because systemic disorders and diseases affect both organs (alcohol abuse, drugs, inflammation, autoimmunity, infections) and because of complex cardiohepatic interactions. The latter, which are the focus of this review, include the development of acute cardiogenic liver injury and congestive hepatopathy in HF as well as cardiac dysfunction and failure in the setting of liver cirrhosis, nonalcoholic fatty liver disease, and sequelae following liver transplantation. Read More

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December 2018

Iron Deficiency in Heart Failure: An Overview.

JACC Heart Fail 2018 Dec 7. Epub 2018 Dec 7.

Division of Cardiology and Metabolism-Heart Failure, Cachexia and Sarcopenia, Department of Cardiology, Campus Virchow-Klinikum, Charité-Universitätsmedizin Berlin, Berlin, Germany; Berlin-Brandenburg Center for Regenerative Therapies, Charité-Universitätsmedizin Berlin, Berlin, Germany.

Iron deficiency is an extremely common co-morbidity in patients with heart failure, affecting up to 50% of all ambulatory patients. It is associated with reduced exercise capacity and physical well-being and reduced quality of life. Cutoff values have been identified for diagnosing iron deficiency in heart failure with reduced ejection fraction as serum ferritin, <100 μg/l, or ferritin, 100 to 300 μg/l, with transferrin saturation of <20%. Read More

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December 2018

3D Printing and Heart Failure: The Present and the Future.

JACC Heart Fail 2018 Dec 10. Epub 2018 Dec 10.

Department of Internal Medicine, Division of Cardiology, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, New York.

Advanced imaging modalities provide essential anatomic and spatial information in patients with complex heart disease. Two-dimensional imaging can be limited in the extent to which true 3-dimensional (3D) relationships are represented. The application of 3D printing technology has increased the creation of physical models that overcomes the limitations of a 2D screen. Read More

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December 2018
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Uridine adenosine tetraphosphate and purinergic signaling in cardiovascular system: an update.

Pharmacol Res 2018 Dec 13. Epub 2018 Dec 13.

Division of Experimental Cardiology, Department of Cardiology, Thoraxcenter, Erasmus University Medical Center, Rotterdam, the Netherlands.

Uridine adenosine tetraphosphate (UpA), biosynthesized by activation of vascular endothelial growth factor receptor (VEGFR) 2, was initially identified as a potent endothelium-derived vasoconstrictor in perfused rat kidney. Subsequently, the effect of UpA on vascular tone regulation was intensively investigated in arteries isolated from different vascular beds in rodents including rat pulmonary arteries, aortas, mesenteric and renal arteries as well as mouse aortas, in which UpA produces vascular contraction. In contrast, UpA produces vascular relaxation in porcine coronary small arteries and rat aortas. Read More

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December 2018

Transcatheter aortic valve replacement outcomes in Japan: Optimized CathEter vAlvular iNtervention (OCEAN) Japanese multicenter registry.

Cardiovasc Revasc Med 2018 Dec 4. Epub 2018 Dec 4.

Department of cardiology, Keio University School of Medicine, Tokyo, Japan.

Objectives: We aimed to assess real-world clinical outcomes of transcatheter aortic valve replacement (TAVR) in Japan.

Background: Data are limited concerning procedural safety and valve performance following TAVR in Japanese. A program by an on-site proctor and procedure screening system was applied during TAVR introduction. Read More

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December 2018

PFO and Cryptogenic Stroke: When Should It be Closed?

Rev Esp Cardiol (Engl Ed) 2018 Dec 12. Epub 2018 Dec 12.

Department of Cardiology, University Hospital of Bern, Bern, Switzerland. Electronic address:

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December 2018

Percutaneous Aortic-to-Right Atrial Fistula Closure as a Complication of Surgical Aortic Valve Replacement.

JACC Cardiovasc Interv 2018 Dec 7. Epub 2018 Dec 7.

Division of Cardiology, American University of Beirut Medical Center, Beirut, Lebanon. Electronic address:

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December 2018

Occlusion of an Extremely Large Left Atrial Appendage Using the "Double-LAmbre Technique".

JACC Cardiovasc Interv 2018 Dec 7. Epub 2018 Dec 7.

Division of Cardiology, Department of Medicine and Therapeutics, Prince of Wales Hospital, Chinese University of Hong Kong, Hong Kong SAR, China. Electronic address:

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December 2018

Completely Percutaneous Transaxillary Aortic Valve Implantation Under Local Anesthesia: A Minimalist Alternative Access Approach.

JACC Cardiovasc Interv 2018 Dec 7. Epub 2018 Dec 7.

Department of Interventional Cardiology, Erasmus University Medical Center, Rotterdam, the Netherlands. Electronic address:

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December 2018

The challenge of sudden cardiac arrest in patients with structural heart disease: Still a long way to go.

Trends Cardiovasc Med 2018 Nov 27. Epub 2018 Nov 27.

Department of Molecular Medicine, Section of Cardiology, University of Pavia, Pavia, Italy; Cardiac Intensive Care Unit, Arrhythmia and Electrophysiology and Experimental Cardiology, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy. Electronic address:

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November 2018

Selective Referral Using CCTA Versus Direct Referral for Individuals Referred to Invasive Coronary Angiography for Suspected CAD: A Randomized, Controlled, Open-Label Trial.

JACC Cardiovasc Imaging 2018 Dec 6. Epub 2018 Dec 6.

Dalio Institute of Cardiovascular Imaging, New York-Presbyterian Hospital and Weill Cornell Medicine, New York, New York. Electronic address:

Objectives: This study compared the safety and diagnostic yield of a selective referral strategy using coronary computed tomographic angiography (CCTA) compared with a direct referral strategy using invasive coronary angiography (ICA) as the index procedure.

Background: Among patients presenting with signs and symptoms suggestive of coronary artery disease (CAD), a sizeable proportion who are referred to ICA do not have a significant, obstructive stenosis.

Methods: In a multinational, randomized clinical trial of patients referred to ICA for nonemergent indications, a selective referral strategy was compared with a direct referral strategy. Read More

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December 2018

Changes in Coronary Plaque Composition in Patients With Acute Myocardial Infarction Treated With High-Intensity Statin Therapy (IBIS-4): A Serial Optical Coherence Tomography Study.

JACC Cardiovasc Imaging 2018 Dec 6. Epub 2018 Dec 6.

Department of Cardiology, Bern University Hospital, Bern, Switzerland.

Objectives: This study assessed changes in optical coherence tomography (OCT)-defined plaque composition in patients with ST-elevation myocardial infarction (STEMI) receiving high-intensity statin treatment.

Background: OCT is a high-resolution modality capable of measuring plaque characteristics including fibrous cap thickness (FCT) and macrophage infiltration. There is limited in vivo evidence regarding the effects of statins on OCT-defined coronary atheroma composition and no evidence in the context of STEMI. Read More

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December 2018

Machine Learning for Data-Driven Discovery: The Rise and Relevance.

JACC Cardiovasc Imaging 2018 Dec 6. Epub 2018 Dec 6.

Division of Cardiology, WVU Heart & Vascular Institute, West Virginia University, Morgantown, West Virginia.

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December 2018

The Impact of Spironolactone in Heart Failure With Preserved Ejection Fraction: What Phase of Diastole Is Helped?

JACC Cardiovasc Imaging 2018 Dec 6. Epub 2018 Dec 6.

Department of Cardiology, Bluhm Cardiovascular Institute, Northwestern University, Chicago, Illinois.

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December 2018

Relative Left Ventricular Apical Sparing of Longitudinal Strain in Cardiac Amyloidosis: Is it Just Amyloid Infiltration?

JACC Cardiovasc Imaging 2018 Dec 6. Epub 2018 Dec 6.

National Amyloidosis Centre, University College London, Royal Free Hospital, London, United Kingdom.

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December 2018

Cardiac Magnetic Resonance Normal Reference Values of Biventricular Size and Function in Male Athlete's Heart.

JACC Cardiovasc Imaging 2018 Dec 6. Epub 2018 Dec 6.

Department of Medical Biotechnologies, Division of Cardiology, University of Siena, Siena, Italy.

Objectives: The aim of this meta-analysis was to derive normal reference values of biventricular size and function estimated by cardiac magnetic resonance (CMR) in competitive athletes.

Background: Exercise-induced enlargement of cardiac chambers is commonly observed in competitive athletes. However, ventricular dilatation is also a common phenotypic expression of life-threatening cardiomyopathies. Read More

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December 2018

Sinus Venosus Defects: Anatomic Variants and Transcatheter Closure Feasibility Using Virtual Reality Planning.

JACC Cardiovasc Imaging 2018 Dec 6. Epub 2018 Dec 6.

Department of Pediatrics (Cardiology), University of Texas Southwestern Medical Center, Children's Medical Center Dallas, Dallas, Texas; Department of Radiology, University of Texas Southwestern Medical Center, Children's Medical Center Dallas, Dallas, Texas.

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December 2018

Prognosticating in Cardiac Amyloidosis: Let Me Count the Ways.

JACC Cardiovasc Imaging 2018 Dec 6. Epub 2018 Dec 6.

Department of Internal Medicine, Division of Cardiology, Center for Cardiac Amyloidosis, Columbia University Medical Center, New York, New York. Electronic address:

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December 2018

Cardiac Magnetic Resonance Imaging in Athletes: Acquiring the Bigger Picture.

JACC Cardiovasc Imaging 2018 Dec 6. Epub 2018 Dec 6.

Cardiology Clinical Academic Group, St. George's University of London, London, United Kingdom.

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December 2018

What Lies Within?: Imaging to Detect Ventricular Assist Device Infection.

JACC Cardiovasc Imaging 2018 Dec 6. Epub 2018 Dec 6.

Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, Tennessee.

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December 2018

Proportionate and Disproportionate Functional Mitral Regurgitation: A New Conceptual Framework That Reconciles the Results of the MITRA-FR and COAPT Trials.

JACC Cardiovasc Imaging 2018 Dec 6. Epub 2018 Dec 6.

Division of Cardiology, Department of Internal Medicine, Baylor University Medical Center, Dallas, Texas.

Traditional approaches to the characterization of secondary or functional mitral regurgitation (MR) have largely ignored the critical importance of the left ventricle (LV). We propose that patients with secondary MR represent a heterogenous group, which can be usefully subdivided based on understanding that the effective regurgitant orifice area (EROA) is dependent on left ventricular end-diastolic volume (LVEDV). According to the Gorlin hydraulic orifice equation, patients with heart failure, an LV ejection fraction of 30%, an LVEDV of 220 to 250 ml, and a regurgitant fraction of 50% would be expected to have an EROA of ≈0. Read More

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December 2018

Correlating Pathology to Imaging: Improved Insights Into Peripheral Artery Disease?

JACC Cardiovasc Imaging 2018 Dec 6. Epub 2018 Dec 6.

Division of Cardiology, University of Minnesota and VA Medical Center, Minneapolis, Minnesota.

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December 2018

An unexpected cause of chronic cough in a young woman: Tachycardia-induced cardiomyopathy.

Am J Emerg Med 2018 Dec 10. Epub 2018 Dec 10.

Emergency and Critical Care Center, Kurashiki Central Hospital, Japan.

Heart failure typically manifests with exertional dyspnea or limb edema. Old age, underlying heart disease, and coronary risk factors are known risk factors for heart failure. Thus, congestive heart failure is rarely considered as a differential diagnosis of chronic cough in a previously healthy young person. Read More

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December 2018

AVIATOR: An open international registry to evaluate medical and surgical outcomes of aortic valve insufficiency and ascending aorta aneurysm.

J Thorac Cardiovasc Surg 2018 Oct 26. Epub 2018 Oct 26.

Department of Cardiac Surgery, Institut Mutualiste Montsouris, Paris, France.

Objectives: Current national registries are lacking detailed pathology-driven analysis and long-term patients outcomes. The Heart Valve Society (HVS) aortic valve (AV) repair research network started the Aortic Valve Insufficiency and ascending aorta Aneurysm InternATiOnal Registry (AVIATOR) to evaluate long-term patient outcomes of AV repair and replacement. The purpose of the current report is to describe the AVIATOR initiative and report in a descriptive manner the patients included. Read More

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October 2018

Mid-term clinical outcomes of out-of-hospital cardiac arrest patients treated with targeted temperature management at 34-36 °C versus 32-34 °C.

Heart Lung 2018 Dec 12. Epub 2018 Dec 12.

Department of Cardiology, Institute for Clinical and Experimental Medicine, Videnska 1958/9, 140 21, Prague, Czech Republic; Third Faculty of Medicine, Charles University, Prague, Czech Republic.

Background: Targeted temperature management (TTM) in comatose survivors of out-of-hospital cardiac arrest has been associated with improved neurological outcomes. However, the optimal temperature target for TTM remains unclear.

Objectives: To compare a TTM protocol targeted at 34-36 °C with a protocol targeted at 32-34 °C with reference to both clinical outcomes and acute complications. Read More

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December 2018
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Comparison of the Diagnostic Performance of Coronary Computed Tomography Angiography-Derived Fractional Flow Reserve in Patients With Versus Without Diabetes Mellitus (from the MACHINE Consortium).

Am J Cardiol 2018 Nov 24. Epub 2018 Nov 24.

Department of Radiology & Nuclear Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands; Department of Cardiology, Erasmus University Medical Center, Rotterdam, The Netherlands; Stanford University School of Medicine, Cardiovascular Institute, Stanford, California.

Coronary computed tomography angiography-derived fractional flow reserve (CT-FFR) is a noninvasive application to evaluate the hemodynamic impact of coronary artery disease by simulating invasively measured FFR based on CT data. CT-FFR is based on the assumption of a normal coronary microvascular response. We assessed the diagnostic performance of a machine-learning based application for on-site computation of CT-FFR in patients with and without diabetes mellitus with suspected coronary artery disease. Read More

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November 2018

Glycated Hemoglobin and Outcomes of Heart Failure (from Get With the Guidelines-Heart Failure).

Am J Cardiol 2018 Dec 3. Epub 2018 Dec 3.

Division of Cardiology, Ahmanson-UCLA Cardiomyopathy Center, University of California, Los Angeles, California. Electronic address:

Glycated hemoglobin (HbA) is a risk factor for new onset heart failure (HF). There is however a paucity of data evaluating its association with outcomes in patients with established HF. We assessed the relation of HbA with outcomes among hospitalized HF patients. Read More

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December 2018

Patient-Reported Quality of Life as a Predictor of Mortality and Ventricular Tachyarrhythmia's During 7 Years' Follow-Up in Patients With an Implantable Cardioverter Defibrillator (from the MIDAS Study).

Am J Cardiol 2018 Nov 24. Epub 2018 Nov 24.

Department of Psychology, University of Southern Denmark, Odense, Denmark; Department of Cardiology, Odense University Hospital, Odense, Denmark. Electronic address:

Preliminary evidence suggests that poor patient-reported quality of life (QoL) predicts mortality on the short term in patients with an implantable cardioverter defibrillator (ICD). It is unclear if this association persists on the long term. We evaluated whether patient-reported QoL at the time of implantation predicts mortality and ventricular tachyarrhythmias (VTa's) during 7 years' follow-up in patients with an ICD. Read More

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November 2018

Persistent atrial fibrillation: A systematic review and meta-analysis of invasive strategies.

Int J Cardiol 2018 Nov 29. Epub 2018 Nov 29.

Amsterdam UMC, University of Amsterdam, Department of Cardiology, Heart Center, Meibergdreef 9, Amsterdam, the Netherlands. Electronic address:

Background: Persistent atrial fibrillation (AF) is associated with higher stroke and mortality risk than paroxysmal AF (pAF). Outcomes of catheter or surgical ablation are worse in patients with persistent AF than in pAF, and the optimal invasive rhythm control strategy has not been established.

Purpose: We provide a contemporary systematic overview on efficacy and safety of catheter and minimally-invasive surgical ablation for persistent AF. Read More

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November 2018

Lixisenatide enhances mitochondrial biogenesis and function through regulating the CREB/PGC-1α pathway.

Authors:
Zhen Zhao Yanhua Pu

Biochem Biophys Res Commun 2018 Dec 12. Epub 2018 Dec 12.

Department of Cardiology, The No.4 Hospital of Jinan, 250031, Shandong, China. Electronic address:

Mitochondrial dysregulation has been associated with vascular endothelial dysfunction and pathophysiological development of cardiovascular diseases. Lixisenatide is a drug approved by the US Food and Drug Administration for the treatment of type 2 diabetes (T2D). Little information regarding the effects of lixisenatide on mitochondrial function in endothelial cells has been reported before. Read More

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December 2018

The omega-3 index in patients with heart failure: A prospective cohort study.

Prostaglandins Leukot Essent Fatty Acids 2019 Jan 28;140:34-41. Epub 2018 Nov 28.

Comprehensive Heart Failure Center, University and University Hospital Würzburg, Germany; Dept. of Internal Medicine I - Cardiology, University Hospital Würzburg, Germany. Electronic address:

Background: Epidemiologic studies on the omega-3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) in heart failure are scarce, while one large intervention trial demonstrated a modest benefit.

Methods: This is a secondary analysis from the Interdisciplinary Network Heart Failure (INH) program. Patients hospitalized for systolic heart failure were enrolled and followed for 36 months. Read More

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January 2019

Urinary 8-iso-prostaglandin F as a risk marker for the vulnerability of culprit plaque in diabetic patients with stable coronary artery disease.

Prostaglandins Leukot Essent Fatty Acids 2019 Jan 22;140:11-17. Epub 2018 Nov 22.

Center of Cardiology, Beijing An Zhen Hospital, Capital Medical University, No. 2 Anzhen Road, Chaoyang District, Beijing 100029, China.

We evaluated the association of urinary excretion of 8-iso-prostaglandin F (8-iso-PGF) with the vulnerability of culprit lesions in 156 age- and sex-matched diabetic stable coronary artery disease (CAD) patients with or without thin-capped fibroatheroma (TCFA) identified by iMAP intravascular ultrasound. Fasting urinary 8-iso-PGF level was measured and corrected by creatinine clearance. Compared to non-TCFA group, patients with TCFA had higher urinary 8-iso-PGF levels [114. Read More

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January 2019

Hereditary cardiac amyloidosis associated with Pro24Ser transthyretin mutation: a case report.

J Med Case Rep 2018 Dec 16;12(1):370. Epub 2018 Dec 16.

Department of Clinical Research, Chiba Tokushukai Hospital, Chiba, Japan.

Background: Transthyretin amyloidosis is a systemic disorder caused by extracellular deposition of insoluble amyloid fibrils in peripheral and autonomic nerves, heart, kidney, gastrointestinal tract, and other organs. Hereditary transthyretin amyloidosis is an autosomal dominant disease. More than 120 mutations have been reported in the transthyretin gene with considerable phenotypic heterogeneity and geographic diversity. Read More

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December 2018

Salvanic acid B inhibits myocardial fibrosis through regulating TGF-β1/Smad signaling pathway.

Biomed Pharmacother 2018 Dec 12;110:685-691. Epub 2018 Dec 12.

Department of Cardiology, Chongqing Hospital of Traditional Chinese Medicine, Chongqing 400021, PR China. Electronic address:

Objective: Salvanic Acid B (Sal B) was proved to show significant effect against fibrosis and myocardial injury. This study aimed to investigate the protective effects and the mechanisms of Sal B on myocardial fibrosis.

Methods: The mice were randomly assigned to five groups: control group, model group, positive group, low-dose group, high-dose group. Read More

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December 2018
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Gut microbiota-dependent trimethylamine-N-oxide (TMAO) shows a U-shaped association with mortality but not with recurrent venous thromboembolism.

Thromb Res 2018 Dec 6;174:40-47. Epub 2018 Dec 6.

Center for Molecular Cardiology, Laboratory for Platelet Research, University of Zurich, Schlieren, Switzerland; Department of Internal Medicine, Cantonal Hospital of Baden, Baden, Switzerland. Electronic address:

Introduction: Gut microbiota-dependent trimethylamine-N-oxide (TMAO) correlates with arterial thrombotic events including myocardial infarction and stroke, and mortality. However, the association of TMAO with recurrent venous thromboembolism (VTE) and mortality remains unknown.

Methods: TMAO plasma levels were assessed by high performance liquid chromatography in 859 patients aged ≥65 years with acute VTE and categorized into low (<2. Read More

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December 2018
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Prescription patterns of direct oral anticoagulants in pulmonary embolism: A prospective multicenter French registry.

Thromb Res 2018 Dec 8;174:27-33. Epub 2018 Dec 8.

Department of Cardiology, EA3920, University Hospital Besançon, Boulevard Fleming, 25030 Besançon, France. Electronic address:

Background: Data regarding the use of direct oral anticoagulants (DOACs) for the treatment of acute pulmonary embolism (PE) are sparse. We conducted a prospective multicentre registry study to describe patterns of DOAC prescription for the treatment of acute PE, and the associated risk of 6-month adverse events in daily practice.

Methods: We included all PE patients discharged since the availability of DOACs for the dedicated indication of acute PE treatment. Read More

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December 2018
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Anti-depressive effect of Shuangxinfang on rats with acute myocardial infarction: Promoting bone marrow mesenchymal stem cells mobilization and alleviating inflammatory response.

Biomed Pharmacother 2018 Dec 12;111:19-30. Epub 2018 Dec 12.

The Third Affiliate Hospital of Beijing University of Chinese Medicine, Beijing 100029, China. Electronic address:

Bone marrow mesenchymal stem cells (BM-MSCs) are recruited to injured site for cardiac self-repairing in acute myocardial infarction (AMI), but the spontaneous mobilization of BM-MSCs is insufficient for self-repairing. Inflammation initiated by necrosis cardiomyocytes induced cardiac remodeling and depression. Given the anti-inflammatory effects of BM-MSCs and the inextricably relationship among inflammation, ventricular remodeling and depression following AMI, methods focused on enhancing BM-MSCs mobilization are promising. Read More

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December 2018

Variety matters: Diverse functions of monocyte subtypes in vascular inflammation and atherogenesis.

Vascul Pharmacol 2018 Dec 12. Epub 2018 Dec 12.

Cardiology and Angiology, Philipps-University Marburg, Marburg, Germany. Electronic address:

Monocytes are important mediators of the innate immunity by recognizing and attacking especially bacterial pathogens but also play crucial roles in various inflammatory diseases, including vascular inflammation and atherosclerosis. Maturation, differentiation and function of monocytes have been intensively explored for a long time in innumerable experimental and clinical studies. Monocytes do not represent a uniform cell type but could be further subdivided into subpopulations with distinct features and functions. Read More

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December 2018