303,809 results match your criteria Cardiology in the Young[Journal]


Peripheral Insulin Extraction in Non-Diabetic Subjects and Type 2 Diabetes Mellitus Patients.

Exp Clin Endocrinol Diabetes 2018 Dec 17. Epub 2018 Dec 17.

Department of Internal Medicine, Spaarne Gasthuis, Haarlem, The Netherlands.

Background: Insulin has to be transported across the capillary endothelium to stimulate muscle glucose uptake. We investigated insulin uptake from the peripheral circulation in non-diabetic (ND) individuals and in type 2 diabetes (T2D) patients.

Methods: Single-center cross-sectional study involving 40 ND (age 65±11 years) and 30 T2D patients (age 67±8 years). Read More

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December 2018

Phenotypic Heterogeneity within Members of a Family Carrying the Same RBM20 Mutation R634W.

Cardiology 2018 Dec 17;141(3):150-155. Epub 2018 Dec 17.

Molecular Immunopathology and Histocompatibility Unit, Division of Molecular Genetics, Onassis Cardiac Surgery Center, Athens, Greece.

Objective: We present the genotypic and phenotypic characterization of a family displaying dilated cardiomyopathy (DCM).

Methods: The proband and his relatives underwent full cardiological assessment. Genetic analysis of the proband was performed with the use of next-generation sequencing technology. Read More

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December 2018

EDUCATIONAL SERIES IN CONGENITAL HEART DISEASE: Tetralogy of Fallot: diagnosis to long-term follow-up.

Authors:
R Bedair X Iriart

Echo Res Pract 2019 Mar;6(1):R9-R23

Department of Pediatric and Adult Congenital Cardiology, Hôpital Cardiologique du Haut-Lévêque, CHU de Bordeaux, Pessac, France.

Tetralogy of Fallot (TOF) is the most common cyanotic congenital heart defect, affecting 3 in 10,000 live births. Surgical correction in early childhood is associated with good outcomes, but lifelong follow-up is necessary to identify the long-term sequelae that may occur. This article will cover the diagnosis of TOF in childhood, the objectives of surveillance through adulthood and the value of multi-modality imaging in identifying and guiding timely surgical and percutaneous interventions. Read More

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Association between ambient particulate matter air pollution and ST-elevation myocardial infarction: A case-crossover study in a Chinese city.

Chemosphere 2018 Dec 12;219:724-729. Epub 2018 Dec 12.

Department of Cardiology, Yancheng Hospital Affiliated to Xuzhou Medical University and the First Hospital of Yancheng, Yancheng, 224006, China. Electronic address:

Background: Abundant epidemiological studies have revealed that short-term exposure to ambient air pollution increased the incidence of ischemic heart diseases. However, few investigations have explored the association between air pollution and ST-elevation myocardial infarction (STEMI), one major subtype of such events.

Methods: We conducted a time-stratified case-crossover study in two major hospitals of Yancheng, a city in East China, from January 2015 to February 2018. Read More

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December 2018

TCF7L2 and EGR1 synergistic activation of transcription of LCN2 via an ERK1/2-dependent pathway in esophageal squamous cell carcinoma cells.

Cell Signal 2018 Dec 14. Epub 2018 Dec 14.

Department of Pathology, Shantou Central Hospital, Affiliated Shantou Hospital of Sun Yat-sen University, Shantou 515041, China; Guangdong Province Key Laboratory of Malignant Tumor Epigenetics and Genes Regulation, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, China. Electronic address:

High level expression of lipocalin 2 (LCN2) usually indicates poor prognosis in esophageal squamous cell carcinoma (ESCC) and many other cancers. Our previous study showed LCN2 promotes migration and invasion of ESCC cells through a novel positive feedback loop. However, the key transcription activation protein (KTAP) in the loop had not yet been identified. Read More

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December 2018

Systemwide clinical assessment of functioning based on the International Classification of Functioning, Disability and Health (ICF) in China: Interrater reliability, convergent, known group, and predictive validity of the ICF Generic-6.

Arch Phys Med Rehabil 2018 Dec 14. Epub 2018 Dec 14.

Department of Rehabilitation Medicine, the First Affiliated Hospital of Nanjing Medical University, Nanjing, China. Electronic address:

Objective: To validate the ICF Generic-6 in daily routine clinical practice in Mainland China. Specific objectives were to a) analyse the interrater reliability, b) convergent validity, c) known group validity and d) predictive validity of the ICF Generic-6.

Design: Multi-centre prospective cohort study. Read More

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December 2018

TUSARC PROGNOSTIC: Prognostic value of high sensitivity troponin T assay in asymptomatic high cardiovascular risk patients.

Am J Med 2018 Dec 14. Epub 2018 Dec 14.

Clinical testing laboratory, Hospital Santos Reyes Aranda de Duero Burgos, Spain.

Objectives: Prognostic value of high-sensitivity cardiac troponin T assays (hs-cTnT) have been carried out on selected populations in different studies and in registries of low cardiovascular risk general population. The aim of this study is to determine the prognostic value of hs-cTnT in a Spanish asymptomatic very high cardiovascular risk population.

Method: From previously prospective cohort of TUSARC (troponina T UltraSensible en pacientes Asintomáticos de alto Riesgo Cardiovascular) registry, follow up was done in 602 patients (93,18%). Read More

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December 2018
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Disconnect between Fibrotic Response and Right Ventricular Dysfunction.

Am J Respir Crit Care Med 2018 Dec 17. Epub 2018 Dec 17.

Ludwig Boltzmann Institute for Lung Vascular Research, Graz, Austria ;

Rationale: Remodeling and fibrosis of the right ventricle (RV) may cause RV dysfunction and poor survival in patients with pulmonary hypertension (PH).

Objectives: To investigate the consequences of RV fibrosis modulation and the accompanying cellular changes on RV function.

Methods: Expression of fibrotic markers was assessed in the RV of PH patients, the murine pulmonary artery banding (PAB)-, and rat monocrotaline-, and Sugen5416/hypoxia models. Read More

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December 2018

Proteomic analysis of heart failure hospitalization among patients with chronic kidney disease: The Heart and Soul Study.

PLoS One 2018 17;13(12):e0208042. Epub 2018 Dec 17.

Department of Medicine, University of California San Francisco/ San Francisco VA Medical Center, San Francisco, California, United States of America.

Background: Patients with chronic kidney disease (CKD) are at increased risk for heart failure (HF). We aimed to investigate differences in proteins associated with HF hospitalizations among patients with and without CKD in the Heart and Soul Study.

Methods And Results: We measured 1068 unique plasma proteins from baseline samples of 974 participants in The Heart and Soul Study who were followed for HF hospitalization over a median of 7 years. Read More

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December 2018

The predictive value of Cardiodynamicsgram in myocardial perfusion abnormalities.

PLoS One 2018 17;13(12):e0208859. Epub 2018 Dec 17.

School of Automation Science and Engineering, South China University of Technology, Guangzhou, Guangdong, China.

Myocardial perfusion abnormalities are the first sign of the ischemic cascade in the development of coronary artery disease (CAD). Thus, the early detection of myocardial perfusion abnormalities is significant for the prevention of CAD. Recently, a novel noninvasive method named Cardiodynamicsgram (CDG) has been proposed for early detection of CAD. Read More

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December 2018
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Role of CTRP3, CTRP9 and MCP-1 for the evaluation of T2DM associated coronary artery disease in Egyptian postmenopausal females.

PLoS One 2018 17;13(12):e0208038. Epub 2018 Dec 17.

Biochemistry Department, Faculty of Pharmacy, Ain Shams University, African Union Authority St. Abassia, Cairo, Egypt.

C1q complement/tumor necrosis factor (TNF)-related protein (CTRP) family comprises of 15 proteins that posses important implications in energy homeostasis, infection and inflammation. However, their roles in diabetes mellitus (DM) and its vascular complications have not been completely assessed. This works aims to study the association of two CTRPs; 3 and 9, with pro-inflammatory cytokine monocyte chemoattractant protein-1 (MCP-1), and biochemical parameters of type 2 diabetes (T2D), dyslipidemia and coronary artery disease (CAD). Read More

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December 2018

Effect of High-Dose Statin Pretreatment for Myocardial Perfusion in Patients Receiving Percutaneous Coronary Intervention (PCI): A Meta-Analysis of 15 Randomized Studies.

Med Sci Monit 2018 Dec 17;24:9166-9176. Epub 2018 Dec 17.

Division of Nephrology, First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China (mainland).

BACKGROUND For coronary artery disease, percutaneous coronary intervention (PCI) is the preferred treatment. Reperfusion injury is a common and serious complication of PCI. Studies showed that early statin therapy has a favorable prognostic impact for patients undergoing PCI. Read More

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December 2018
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Antegrade Transpulmonary Blood Flow: Essential for Surviving Veno-Arterial Extracorporeal Membrane Oxygenation.

Crit Care Med 2019 Jan;47(1):e70-e71

Cardiac Arrest Center, Department of Cardiology and Angiology, Hannover Medical School, Hannover, Germany Cardiovascular Research Foundation, New York, NY Division of Cardiology, Pulmonology, and Vascular Medicine, Medical Faculty, Heinrich-Heine-University, Düsseldorf, Germany.

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January 2019

The authors reply.

Crit Care Med 2019 Jan;47(1):e66-e67

Department of Cardiology, Heart Institute (InCor), Hospital das Clinicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil Surgical Intensive Care Unit and Department of Anesthesiology, Heart Institute (InCor), Hospital das Clinicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute and Vita-Salute San Raffaele University, Milan, Italy.

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January 2019

Nutrition Support is a Potential Confounding Factor for the Relationship Between Body Weight Variation and the Risk of Bedsore.

Crit Care Med 2019 Jan;47(1):e64

Department of Respiratory, Affiliated Dongyang Hospital of Wenzhou Medical University, Dongyang, Zhejiang, P.R. China; Department of Biomedical Sciences Laboratory, Affiliated Dongyang Hospital of Wenzhou Medical University, Dongyang, Zhejiang, China; Department of Cardiology, Affiliated Dongyang Hospital of Wenzhou Medical University, Dongyang, Zhejiang, China.

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January 2019

Impact of preclinical carotid atherosclerosis on global cardiovascular risk stratification and events in a 10-year follow-up: comparison between the algorithms of the Framingham Heart Study, the European SCORE and the Italian 'Progetto Cuore'.

J Cardiovasc Med (Hagerstown) 2018 Dec 14. Epub 2018 Dec 14.

Chair and Division of Cardiology, University Hospital Policlinico 'Paolo Giaccone', Palermo, Italy.

Background: The aim of the study was to compare three widely used algorithms for stratification of the global cardiovascular risk (GCVR): the Framingham Heart Study (FHS) score, the European systemic coronary risk estimation (SCORE) and the Italian 'Progetto Cuore' (heart project) score. It was also investigated how preclinical carotid atherosclerosis (pre-ATS) might influence the incidence and improve the risk prediction of cerebrovascular and cardiovascular events.

Methods: Subjects (n = 358) without previous history of cardiovascular disease (CVD) were recruited and the GCVR was calculated for each patient. Read More

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December 2018

The Value of Imaging-The Case for Coronary Computed Tomography Angiography.

J Thorac Imaging 2019 Jan;34(1):2-3

Department of Medical Imaging and Division of Cardiology, St. Paul's Hospital, University of British Columbia, Vancouver, BC, Canada.

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January 2019

Detection of myocardial inflammation by 18F-FDG-PET/CT in patients with systemic sclerosis without cardiac symptoms: a pilot study.

Clin Exp Rheumatol 2018 Dec 7. Epub 2018 Dec 7.

Department of Nuclear Medicine, University of Szeged, Hungary.

Objectives: Primary cardiac manifestation is a common complication of systemic sclerosis (SSc) with poor prognosis. The aim of the current study was to detect potential myocardial inflammation present in asymptomatic SSc patients by 18F-FDG-PET/CT and to investigate its relationship with early signs of myocardial dysfunction as detected by 2D speckle tracking echocardiography (2DSTE).

Methods: Sixteen consecutive patients with SSc and 9 control patients without clinical evidence of cardiac involvement were enrolled in the study. Read More

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December 2018
1 Read

Preoperative β-Blockers for Isolated Coronary Artery Bypass Graft.

Circ Cardiovasc Qual Outcomes 2018 Dec;11(12):e005027

Department of Cardiothoracic Surgery, The Heart Hospital Baylor Plano, TX (J.R.E.).

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December 2018

The Need for Speed.

Circ Cardiovasc Qual Outcomes 2018 Dec;11(12):e005234

Division of Cardiology, University of California, Los Angeles (G.C.F.).

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December 2018

Myeloid angiogenic cells exhibit impaired migration, reduced expression of endothelial markers and increased apoptosis in idiopathic pulmonary arterial hypertension.

Can J Physiol Pharmacol 2018 Dec 17. Epub 2018 Dec 17.

St. Michael's Hospital, Cardiology , 30 Bond Street , Toronto, Ontario, Ontario, Canada , M5B 1W8 ;

Idiopathic pulmonary arterial hypertension (IPAH) is a rare and devastating condition. There is no known cure for IPAH, and current treatment options are not always effective. Autologous myeloid angiogenic cells (MACs) have been explored as a novel therapy for IPAH but preliminary data from clinical trials show limited beneficial effects. Read More

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December 2018

Prospective associations between cardiac stress, glucose dysregulation and executive cognitive function in Black men: The Sympathetic activity and Ambulatory Blood Pressure in Africans study.

Diab Vasc Dis Res 2018 Dec 17:1479164118816221. Epub 2018 Dec 17.

1 Hypertension in Africa Research Team (HART) and School for Physiology, Nutrition and Consumer Sciences, Faculty of Health Sciences, North-West University, Potchefstroom, South Africa.

Objective:: Glucose dysregulation is an independent risk factor for cardiovascular and neurodegenerative disease development through synaptic dysfunction resulting in cognitive decline. The aim of this study was to study the interplay between impaired glycaemic metabolism (hyperglycaemia and insulin resistance), cardiac stress (cardiac troponin T and N-terminal brain natriuretic peptide) and executive cognitive function prospectively, in a bi-ethnic sex cohort.

Methods:: Black and White teachers (N = 338, aged 20-63 years) from the Sympathetic activity and Ambulatory Blood Pressure in Africans study were monitored over a 3-year period. Read More

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December 2018

GBP1 exerts inhibitory effects on acute viral myocarditis through the inhibition of inflammatory response of macrophage in mice.

Biochem Cell Biol 2018 Dec 17. Epub 2018 Dec 17.

China-Japan Union Hospital of Jilin University, 74569, Cardiology , No. 126, Xiantai Street , Changchun, China , 130031 ;

Viral myocarditis (VMC) is a condition that could potentially progress to dilated cardiomyopathy or congestive heart failure, making it the leading cause of the untimely death in young adults. Interferon-induced GBP1 encodes much GTPase induced by interferon gamma in many eukaryotic cells. However, there is little known regarding the effect of GBP1 on acute VMC (AVMC). Read More

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December 2018

Efficacy and safety of dronedarone in patients with amiodarone-induced hyperthyroidism: a clinical study.

Eur Rev Med Pharmacol Sci 2018 Dec;22(23):8502-8508

Division of Cardiology, University of Rome Tor Vergata, Rome, Italy.

Objective: The aim of the study was to examine the safety and efficacy of dronedarone in patients with a history of atrial fibrillation and amiodarone-induced hyperthyroidism.

Patients And Methods: We conducted a prospective study to evaluate the use of amiodarone and dronedarone in 124 patients with a history of paroxysmal atrial fibrillation who had no additional structural heart disease. All patients received amiodarone 200 mg qd. Read More

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December 2018

Temporal Trends in Unstable Angina Diagnosis Codes for Outpatient Percutaneous Coronary Interventions.

JAMA Intern Med 2018 Dec 17. Epub 2018 Dec 17.

Richard and Susan Smith Center for Outcomes Research in Cardiology, Division of Cardiology, Beth Israel Deaconess Medical and Harvard Medical School, Boston, Massachusetts.

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December 2018

The Safety and Effectiveness of Field Nitroglycerin in Patients with Suspected ST Elevation Myocardial Infarction.

Prehosp Emerg Care 2018 Dec 17:1-28. Epub 2018 Dec 17.

b Department of Emergency Medicine , Harbor-UCLA Medical Center and Los Angeles Biomedical Institute , Torrance , CA , USA ;

Objective: While widely used in the treatment of cardiac conditions, only limited data characterize out-of-hospital nitroglycerin (NTG) use. We sought to determine the safety of out-of-hospital sublingual NTG administered for suspected ST-segment elevation myocardial infarction (STEMI) and its effect on the patient's pain score.

Methods: We prospectively identified adult patients with suspected STEMI transported by paramedics to three PCI-capable hospitals in a large urban-suburban EMS system. Read More

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December 2018

Integrated central blood pressure-aortic stiffness risk score for cardiovascular risk stratification in chronic kidney disease.

Physiol Int 2018 Dec 17:1-12. Epub 2018 Dec 17.

3 1st Department of Medicine, Semmelweis University , Budapest, Hungary.

Background And Aims: The aim of this study was to develop an integrated central blood pressure-aortic stiffness (ICPS) risk score to predict cardiovascular events.

Methods: It was a retrospective cohort study. A total of 100 chronic kidney disease (CKD) patients on conservative therapy were included. Read More

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December 2018

A multicentered evaluation of ablation at higher power guided by ablation index: establishing ablation targets for pulmonary vein isolation.

J Cardiovasc Electrophysiol 2018 Dec 16. Epub 2018 Dec 16.

Barts Heart Centre, St Bartholomew's Hospital, Barts Health NHS Trust, London, United Kingdom.

Background: Pulmonary vein isolation (PVI) using high power delivered by surround flow (STSF) catheters guided by ablation index (AI) was evaluated in a multicenter registry.

Methods: Patients with paroxysmal AF underwent PVI with STSF catheters using 30W on the posterior wall and 40W elsewhere. AI targets were 350 posterior wall and 450 elsewhere. Read More

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December 2018

Transient power elevation during iron dextran infusion in a patient with a continuous-flow left ventricular assist device.

Int J Artif Organs 2018 Dec 16:391398818818565. Epub 2018 Dec 16.

6 Department of Thoracic and Cardiovascular Surgery, Cleveland Clinic, Cleveland, OH, USA.

Anemia is common in patients with mechanical circulatory support and is associated with increased morbidity. Repletion using parenteral iron infusions has been proven to be beneficial in patients with heart failure. In this report, we describe a case of increased power and flows of continuous-flow left ventricular assist device (LVAD) during an iron dextran infusion. Read More

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December 2018

Gender difference of symptoms of acute coronary syndrome among Chinese patients: a cross-sectional study.

Eur J Cardiovasc Nurs 2018 Dec 17:1474515118820485. Epub 2018 Dec 17.

5 LinYi People's Hospital, Nursing Administrative Department, China.

Background:: The incidence of acute coronary syndrome is increasing in China.

Objective:: To investigate gender differences in Chinese patients' acute coronary syndrome symptoms, attribution of symptoms and reasons for seeking medical service.

Methods:: This was a cross-sectional, multicentre study. Read More

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December 2018

Higher blood pressure predicts diabetes and enhances long-term risk of CVD events in individuals with impaired glucose tolerance- 23-year follow-up of the Daqing Diabetes Prevention Study.

J Diabetes 2018 Dec 16. Epub 2018 Dec 16.

Center of Endocrinology and Cardiology, Fuwai Hospital, Chinese Academy of Medical Sciences, Beijing, China.

Background: Hypertension is more prevalent in subjects with impaired glucose tolerance (IGT), but whether higher blood pressure per se or the mild hyperglycemia in combination with the hypertension enhanced the risk of cardiovascular disease (CVD) remains unclear.

Methods: 568 participants with IGT in the original Daqing diabetes prevention study, 297 with hypertension (HBP) and 271 without hypertension (NBP), were enrolled in 1986 and the intervention phase lasted for 6 years. In 2009, they were followed up to assess the outcomes of cardiovascular events (including stroke and myocardial infarction) and incidence of diabetes. Read More

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December 2018

Pre-procedural imaging to guide transcoronary ethanol ablation for refractory septal ventricular tachycardia.

J Cardiovasc Electrophysiol 2018 Dec 16. Epub 2018 Dec 16.

Arrhythmia Unit. Cardiology Service. Hospital Universitari Vall d'Hebron.

Background: Radiofrequency ablation (RF) of ventricular tachycardia (VT) due to intramural foci has a high recurrence rate. Several techniques as bipolar ablation, irrigated needle ablation catheter and retrograde coronary venous ethanol ablation have been suggested. Transarterial coronary ethanol ablation (TCEA) can be also effective. Read More

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December 2018

Prevalence of Noonan spectrum disorders in a pediatric population with valvar pulmonary stenosis.

Congenit Heart Dis 2018 Dec 16. Epub 2018 Dec 16.

The Heart Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.

Objective: To evaluate the prevalence of Noonan spectrum disorders (NSD) in a pediatric population with valvar pulmonary stenosis (vPS) and identify the clinical characteristics that differentiate those with NSD from those without NSD.

Design: A retrospective chart review of 204 patients diagnosed with vPS between 9/1/2012 and 12/1/2016 at a pediatric medical center was performed. The quantitative features of vPS, genetic diagnosis information, and phenotypic characteristics of Noonan syndrome were collected. Read More

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December 2018

Aortic root changes before and after surgery for chronic aortic dilatation: A 3D Echocardiographic study.

Echocardiography 2018 Dec 16. Epub 2018 Dec 16.

Division of Cardiology, Toronto General Hospital, University of Toronto, Toronto, Ontario, Canada.

Background: Quantitative 3D assessment of the aortic root may improve planning and success of aortic valve (AV)-sparing operations.

Aims: To use 3D transesophageal echocardiography (TEE) to assess the effect of chronic aortic dilatation on aortic root shape and aortic regurgitation (AR) severity and to examine the effects of AV-sparing operations.

Methods And Results: To determine the changes with chronic aortic dilatation, we studied 48 patients, 23 with aortic dilatation (Group 1 ≤ mild AR, n = 13; Group 2 ≥ moderate AR, n = 10) and 25 Controls. Read More

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December 2018

HSP90 inhibitor 17-AAG prevents apoptosis of cardiomyocytes via miR-93-dependent mitigation of endoplasmic reticulum stress.

J Cell Biochem 2018 Dec 16. Epub 2018 Dec 16.

Department of Cardiology, Huaihe Hospital, Henan University, Kaifeng City, Henan, China.

Heart failure accounts for substantial morbidity and mortality worldwide. Accumulating evidence suggests that aberrant cardiac cell death caused by endoplasmic reticulum stress (ERS) is often associated with structural or functional cardiac abnormalities that lead to insufficient cardiac output. The detailed molecular mechanism underlying the pathological death of cardiomyocytes still remains poorly understood. Read More

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December 2018

Association between late gadolinium enhancement and global longitudinal strain in patients with rheumatic mitral stenosis.

Int J Cardiovasc Imaging 2018 Dec 17. Epub 2018 Dec 17.

Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia / National Cardiovascular Center Harapan Kita, Jakarta, Indonesia.

The correlation between the extent of myocardial fibrosis and subclinical left ventricle (LV) systolic dysfunction in rheumatic mitral stenosis (MS) has not been widely studied. We sought to evaluate the correlation between the extent of LV myocardial fibrosis quantified by late gadolinium enhancement (LGE) using cardiac magnetic resonance (CMR) and global longitudinal strain (GLS) by speckle tracking echocardiography (STE) in patients with rheumatic MS. We prospectively evaluated 36 consecutive rheumatic MS patients who were planning to undergo mitral valve surgery. Read More

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December 2018

Congenital Heart Surgical Admissions in Patients with Trisomy 13 and 18: Frequency, Morbidity, and Mortality.

Pediatr Cardiol 2018 Dec 17. Epub 2018 Dec 17.

Department of Pediatric, MassGeneral Hospital for Children, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.

Congenital heart defects are common among patients with trisomy 13 and 18; surgical repair has been controversial and rarely studied. We aimed to assess the frequency of cardiac surgery among admissions with trisomy 13 and 18, and evaluate their associations with resource use, complications, and mortality compared to admissions without these diagnoses. We evaluated congenital heart surgery admissions of ages < 18 years in the 1997, 2000, 2003, 2006, and 2009 Kids' Inpatient Database. Read More

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December 2018

Use of Antiplatelet Agents Is Inversely Associated With Liver Fibrosis in Patients With Cardiovascular Disease.

Hepatol Commun 2018 Dec 5;2(12):1601-1609. Epub 2018 Oct 5.

Department of Internal Medicine 1 J.W. Goethe-University Hospital Frankfurt Germany.

Platelets participate in the development of liver fibrosis in animal models, but little is known about the benefit of antiplatelet agents in preventing liver fibrosis in humans. We therefore explored the relationship between the use of antiplatelet agents and liver fibrosis in a prospective cohort study of patients at high risk of liver fibrosis and cardiovascular events. Consecutive patients undergoing elective coronary angiography at the University Hospital Frankfurt were prospectively included in the present study. Read More

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December 2018

Training: improving antenatal detection and outcomes of congenital heart disease.

BMJ Open Qual 2018 24;7(4):e000276. Epub 2018 Nov 24.

School of Sport and Exercise Sciences and College of Engineering, Swansea University, Medical Physics and Biomedical Engineering, Swansea, UK.

Objectives: This study describes the design, delivery and efficacy of a regional fetal cardiac ultrasound training programme. This programme aimed to improve the antenatal detection of congenital heart disease (CHD) and its effect on fetal and postnatal outcomes.

Design Setting And Participants: This was a prospective study that compared antenatal CHD detection rates by professionals from 13 hospitals in Wales before and after engaging in our 'skills development programme'. Read More

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November 2018

Prognostic impact of bundle branch block after acute coronary syndrome. Does it matter if it is left of right?

Int J Cardiol Heart Vasc 2019 Mar 3;22:31-34. Epub 2018 Dec 3.

Cardiology Department, Santa Marta Hospital, Central Lisbon University Hospital, Lisbon, Portugal.

Background: In previous guidelines, acute coronary syndromes (ACS) with new or presumably new left bundle branch block (LBBB) were an indication for reperfusion treatment, preferably with primary angioplasty. Recent guidelines also included the presence of right bundle branch block (RBBB) in this recommendation. It was our objective to evaluate in a population of patients with ACS the differential impact of RBBB and LBBB in prognosis. Read More

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The Association of Fasting Glucose, Insulin, and C-Peptide, with 19-Year Incidence of Coronary Heart Disease in Older Japanese-American Men; the Honolulu Heart Program.

Geriatrics (Basel) 2018 22;3(2). Epub 2018 Apr 22.

Department of Geriatric Medicine, John A. Burns School of Medicine, University of Hawaii, Hale Pulama Mau, 9th Floor, 347 N. Kuakini St, Honolulu, Hawaii, 96817, USA.

The role of fasting glucose, insulin levels, and C-peptide in coronary heart disease (CHD) in non-diabetic individuals remains uncertain. We examined the association between fasting glucose, insulin and C-peptide with the long-term incidence of CHD in Japanese-American men. In 1980-1982, from a random sample of the Honolulu Heart Program men ( = 1378), aged 61-81 years, data on several CHD and metabolic risk factors were obtained to examine the relation of fasting glucose, insulin and C-peptide to 19-year CHD incidence. Read More

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The Intersection of Diabetes and Cardiovascular Disease-A Focus on New Therapies.

Front Cardiovasc Med 2018 13;5:160. Epub 2018 Nov 13.

Center for Preventive Cardiology, Knight Cardiovascular Institute, Oregon Health & Science University, Portland, OR, United States.

Diabetes is a leading cause of cardiovascular disease and its associated morbidity. While the medical community has had access to numerous glucose lowering therapies over the last decades, it was not until recently that newer agents demonstrated improvement in cardiovascular outcomes. In particular, diabetes care and management of its attendant cardiovascular risk is now being revolutionized with the development and provision of the SGLT-2 inhibitors and GLP1-receptor agonists. Read More

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November 2018

A simple method to increase the proportion of bone marrow-derived macrophages positive for M-CSFR using the reducing agent dithiothreitol (DTT).

MethodsX 2018 27;5:1540-1548. Epub 2018 Nov 27.

Department of Cardiology, Juntendo University Graduate School of Medicine, Hongo 2-1-1, Bunkyo-ku, Tokyo, 113-8421, Japan.

Only a few bone marrow-derived macrophages (BM-MΦ) are positive for macrophage colony-stimulating factor receptor (M-CSFR). Thus, a method is needed to increase the proportion of BM-MΦ that are positive for M-CSFR to facilitate the investigation of the effects of M-CSFR downregulation on various diseases. We used mouse primary BM-MΦ to evaluate the expression of M-CSFR on the cytoplasmic membrane using flow cytometry. Read More

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November 2018

Death in patients with adaptive servo-ventilation for sleep apnea and no specific SERVE-HF profile: A case series study.

Respir Med Case Rep 2019 26;26:68-72. Epub 2018 Nov 26.

Haut-Leveque Cardiology Hospital, Pessac, France.

Purpose: The SERVE-HF study reported a risk of cardiovascular death associated with adaptive servo-ventilation (ASV) for central sleep apnea in patients with chronic heart failure with reduced left ventricular ejection fraction (LVEF). Therefore, we adopted in May 2015 a safety procedure in our 32 patients with ASV since 2006. It led to ASV removal in four patients due to ≤45% LVEF. Read More

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November 2018

An Unusual Presentation of Parvimonas micra Infective Endocarditis.

Cureus 2018 Oct 13;10(10):e3447. Epub 2018 Oct 13.

Internal Medicine, Woodlands Health Care, Singapore, SGP.

Parvimonas micra has been identified as a prominent oral pathogen. This organism has been implicated in periodontal, soft tissue and bone infections. It causes a subacute presentation with high morbidity. Read More

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October 2018

Rare case of a kidney and inferior vena cava abnormalities with extensive lower extremity deep vein thrombosis in a young healthy male.

Clin Pract 2018 Oct 26;8(4):1079. Epub 2018 Oct 26.

Division of Cardiology, Department of Medicine, East Tennessee State University, Johnson City, TN, USA.

Kidney and inferior vena cava (IVC) abnormalities with extensive deep vein thrombosis (DVT) is a very rare cause of DVT and has a diverse clinical presentation. Computed tomography (CT) angiography is the gold standard for diagnosis and treatment including thrombectomy, thrombolysis and systemic anticoagulation. We present a rare case of active young healthy male admitted with acute onset of right lower extremity pain and swelling who was found to have extensive DVT on doppler ultrasound. Read More

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October 2018

Recurrent shocks in a dual chamber implantable cardioverter defibrillator: Making sense of the chaos.

J Arrhythm 2018 Dec 1;34(6):661-663. Epub 2018 Sep 1.

Arrhythmia Service Division of Cardiology University of Ottawa Heart Institute Ottawa Canada.

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December 2018

Atrio-Hisian block precludes preexcitation-What is the mechanism?

J Arrhythm 2018 Dec 17;34(6):659-660. Epub 2018 Nov 17.

Department of Cardiology Amrita Institute of Medical Sciences Ponekkara, Kochi Kerala India.

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December 2018

Successful percutaneous retrieval of a micra transcatheter pacing system at 8 weeks after implantation.

J Arrhythm 2018 Dec 13;34(6):653-655. Epub 2018 Oct 13.

Division of Cardiology, Cardiovascular and Aortic Center Saiseikai Fukuoka General Hospital Fukuoka Japan.

An 86-year-old woman suffering from repeated methicillin-resistant (MRSA) bacteremia underwent percutaneous lead extraction using an excimer laser. Since negative blood cultures were confirmed three times after lead extraction under intravenous infusion of anti-MRSA drugs, a Micra transcatheter pacing system (Micra TPS) was implanted 7 days after the lead extraction. Although infusion of anti-MRSA drugs was continued for 5 weeks, MRSA was isolated in four separate samples of blood cultures 3 weeks after the discontinuation of the anti-MRSA therapy. Read More

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December 2018

Entrapment and retrieval of a diagnostic electrophysiological catheter in the Chiari network.

J Arrhythm 2018 Dec 3;34(6):647-649. Epub 2018 Sep 3.

Department of Heart Disease Haukeland University Hospital Bergen Norway.

The Chiari networks are reticulated fibers of embryological remnant venous valves in the right atrium. In patients with this congenital variation, manipulation of diagnostic catheters can be difficult, and there is a substantial risk of entrapment during electrophysiological studies. We report a case of successful retraction of a diagnostic catheter entangled in the Chiari network with the use of a lead extraction tool during a scheduled atrial fibrillation ablation. Read More

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December 2018