303,627 results match your criteria Cardiology in review[Journal]


Inhaled Epoprostenol for Pulmonary Hypertension Treatment in Neonates: A 12-Year Experience.

Am J Perinatol 2018 Dec 14. Epub 2018 Dec 14.

Division of Neonatology, Department of Paediatrics, CHU de Québec, Université Laval, Québec City, Québec, Canada.

Background:  Persistent pulmonary hypertension of the newborn (PPHN) occurs in 10% of neonatal respiratory insufficiency. To selectively reduce pulmonary vascular resistance, several treatments have been tried. Inhaled epoprostenol (iPGI) has been used for 12 years in our institution for the management of refractory PPHN despite the gaps in the literature to support this use. Read More

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December 2018

Novel endotypes in heart failure: effects on guideline-directed medical therapy.

Eur Heart J 2018 Dec 13. Epub 2018 Dec 13.

Department of Cardiology, University of Groningen, Hanzeplein 1, Groningen, the Netherlands.

Aims: We sought to determine subtypes of patients with heart failure (HF) with a distinct clinical profile and treatment response, using a wide range of biomarkers from various pathophysiological domains.

Methods And Results: We performed unsupervised cluster analysis using 92 established cardiovascular biomarkers to identify mutually exclusive subgroups (endotypes) of 1802 patients with HF and reduced ejection fraction (HFrEF) from the BIOSTAT-CHF project. We validated our findings in an independent cohort of 813 patients. Read More

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December 2018

Arterial and pulmonary hypertension: risk assessment and current pharmacological and interventional management.

Eur Heart J 2018 Dec;39(47):4127-4131

Imperial College and Consultant and Director of Research, Education & Development, Royal Brompton and Harefield Hospital Trust, London, UK.

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December 2018

Decreased risk of renal impairment in atrial fibrillation patients receiving non-vitamin K antagonist oral anticoagulants: A pooled analysis of randomized controlled trials and real-world studies.

Thromb Res 2018 Dec 6;174:16-23. Epub 2018 Dec 6.

Department of Cardiology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200127, China.

Background: Patients with warfarin have a potential risk of warfarin-related nephropathy, which could result in the discontinuation of anticoagulation therapy. The question of whether non-vitamin K antagonist oral anticoagulants (NOACs) use is associated with increased risk of renal impairment in atrial fibrillation (AF) patients remains unanswered.

Methods: Studies were systematically searched through Medline, Embase, Cochrane Library databases, and ClinicalTrials. Read More

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December 2018
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Recombinant human interleukin-1 receptor antagonist treatment protects rats from myocardial ischemia-reperfusion injury.

Biomed Pharmacother 2018 Dec 11;111:1-5. Epub 2018 Dec 11.

Department of Cardiology, Rui Jin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 20025, PR China. Electronic address:

The interleukin-1 (IL-1) signaling pathway plays a vital role in multiple mechanisms associated with myocardial ischemia-reperfusion (I/R) injury, including inflammation and apoptosis. An IL-1 receptor antagonist (IL-1Ra) can block IL-1 by competitive binding to the IL-1 receptor type I (IL-1RI) and thus may provide a cardioprotective effect. In the present investigation, we determined whether exogenous administration of recombinant human IL-1Ra (rhIL-1Ra) provides a protective role against myocardial I/R injury. Read More

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December 2018

Self-Assembled GFFYK Peptide Hydrogel Enhances the Therapeutic Efficacy of Mesenchymal Stem Cells in a Mouse Hindlimb Ischemia Model.

Acta Biomater 2018 Dec 11. Epub 2018 Dec 11.

Nankai University School of Medicine, Tianjin 300071, China; The Key Laboratory of Bioactive Materials, Ministry of Education, Nankai University, The College of Life Science, Tianjin 300071, China. Electronic address:

Mesenchymal stem cell (MSC) transplantation has emerged as a very promising strategy for the treatments of peripheral artery disease (PAD). However, MSC-based therapies are limited by low cell retention and survival rate in the ischemic zone. Small molecular (SM) hydrogels have shown attractive abilities to enhance the therapeutic effects of human MSCs via promoting their proliferation or maintaining their differentiation potential. Read More

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December 2018

A New Model to Predict Ischemic Stroke in Patients with Atrial Fibrillation Using Warfarin or Direct Oral Anticoagulants.

Heart Rhythm 2018 Dec 11. Epub 2018 Dec 11.

Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA.

Background: Stroke risk stratification scores (e.g., CHADS-VASc) are used to tailor therapeutic recommendations for patients with atrial fibrillation (AF) in different risk groups. Read More

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December 2018

Safety and Feasibility of a Mid-Septal Implantation Technique of A Leadless Pacemaker.

Heart Rhythm 2018 Dec 11. Epub 2018 Dec 11.

Cardiology Division, Department of Medicine, Queen Mary Hospital, the University of Hong Kong, Hong Kong SAR, China;; Division of Cardiology, Department of Medicine, the University of Hong Kong Shenzhen Hospital, China;; Shenzhen Institutes of Research and Innovation, University of Hong Kong, China. Electronic address:

Background: The major risk of implanting leadless pacemaker at the right ventricular apex is cardiac perforation.

Objective: We described and prospectively evaluated the safety and feasibility of a technique for mid-septal implantation of the Micra leadless pacemaker.

Methods: We positioning the device at the center of the cardiac silhouette in the right anterior oblique (RAO) view, towards the left in the left anterior oblique (LAO) view and away from the sternum in the left lateral view. Read More

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December 2018

Drp1/Fis1-mediated mitochondrial fragmentation leads to lysosomal dysfunction in cardiac models of Huntington's disease.

J Mol Cell Cardiol 2018 Dec 11. Epub 2018 Dec 11.

Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA, United States. Electronic address:

Huntington's disease (HD) is a fatal hereditary neurodegenerative disorder, best known for its clinical triad of progressive motor impairment, cognitive deficits and psychiatric disturbances, is caused by CAG-repeat expansion in exon 1 of Huntingtin (HTT). However, in addition to the neurological disease, mutant HTT (mHTT), which is ubiquitously expressed in all tissues, impairs other organ systems. Not surprisingly, cardiovascular dysautonomia as well as the deterioration of circadian rhythms are among the earliest detectable pathophysiological changes in individuals with HD. Read More

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December 2018

Reproducibility of quantitative coronary computed tomography angiography in asymptomatic individuals and patients with acute chest pain.

PLoS One 2018 14;13(12):e0207980. Epub 2018 Dec 14.

Department of Cardiology, Rigshospitalet, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark.

Purpose: Quantitative computed tomography (QCT) provides important prognostic information of coronary atherosclerosis. We investigated intraobserver and interobserver QCT reproducibility in asymptomatic individuals, patients with acute chest pain without acute coronary syndrome (ACS), and patients with acute chest pain and ACS.

Methods: Fifty patients from each cohort, scanned between 01/02/2010-14/11/2013 and matched according to age and gender, were retrospectively assessed for inclusion. Read More

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December 2018

Acute heart failure in Yemen.

J Cardiovasc Med (Hagerstown) 2018 Dec 12. Epub 2018 Dec 12.

Department of Cardiology, 'Sapienza' University of Rome, Rome, Italy.

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December 2018

Society of Cardiovascular Anesthesiologists/European Association of Cardiothoracic Anaesthetists Practice Advisory for the Management of Perioperative Atrial Fibrillation in Patients Undergoing Cardiac Surgery.

Anesth Analg 2019 Jan;128(1):33-42

Department of Perioperative Medicine, Barts Heart Centre, St Bartholomew's Hospital, London, United Kingdom.

Postoperative atrial fibrillation (poAF) is the most common adverse event after cardiac surgery and is associated with increased morbidity, mortality, and hospital and intensive care unit length of stay. Despite progressive improvements in overall cardiac surgical operative mortality and postoperative morbidity, the incidence of poAF has remained unchanged at 30%-50%. A number of evidence-based recommendations regarding the perioperative management of atrial fibrillation (AF) have been released from leading cardiovascular societies in recent years; however, it is unknown how closely these guidelines are being followed by medical practitioners. Read More

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January 2019

The utility of trans thoracic echocardiograhic measures of right ventricular systolic function in a lung resection cohort.

Echo Res Pract 2018 Dec 1. Epub 2018 Dec 1.

B Shelley, Anaesthesia, Pain and Critical Care Medicine, University of Glasgow, Glasgow, United Kingdom of Great Britain and Northern Ireland.

Right ventricular (RV) dysfunction occurs following lung resection and is associated with post-operative complications and long-term functional morbidity. Accurate peri-operative assessment of RV function would have utility in this population. The difficulties of trans thoracic echocardiographic (TTE) assessment of RV function may be compounded following lung resection surgery and no parameters have been validated in this patient group. Read More

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December 2018

Implementing vernakalant: a novel approach to cardioversion.

Authors:
Angela Hall

Emerg Nurse 2018 Dec 11. Epub 2018 Dec 11.

Jersey General Hospital, St Helier, Jersey.

Atrial fibrillation (AF) is the most common arrhythmia, and there is a one in four lifetime risk of developing the condition for people who are over the age of 40. Vernakalant, a new addition to intravenous antiarrhythmic drugs for cardioversion of AF, is the first atrial-specific antiarrhythmic drug for pharmacological cardioversion of recent onset AF and is more effective than placebo and amiodarone. The drug offers patients an alternative to other pharmacological agents for chemical cardioversion and avoids the risks associated with electrical cardioversion. Read More

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December 2018

Prospective study of pulmonary hypertension in preterm infants with bronchopulmonary dysplasia.

Pediatr Pulmonol 2018 Dec 14. Epub 2018 Dec 14.

Department of Pediatrics, Section of Neonatology, Cumming School of Medicine, Calgary, Alberta, Canada.

Objective: To evaluate the prevalence, risk factors, and optimal timing of echocardiogram for pulmonary hypertension (PH) in infants with bronchopulmonary dysplasia (BPD).

Design: In this prospective study, infants with gestational age (GA) <30 weeks admitted to a tertiary NICU between July 2015 and June 2017 who required positive pressure ventilation or oxygen therapy at ≥28 days of life were evaluated with serial echocardiograms at study enrollment (4-6 weeks of age), 32 weeks (only for ≤25 weeks), 36, and 40 weeks post-menstrual age (PMA) for PH.

Results: Of 126 infants (mean birth weight 858 ± 221 g; mean GA 26. Read More

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December 2018

Incremental cost and length of stay associated with postprocedure delirium in transcatheter and surgical aortic valve replacement patients in the United States.

Catheter Cardiovasc Interv 2018 Dec 14. Epub 2018 Dec 14.

Edwards Lifesciences, Irvine, California.

Objectives: To explore the impact of post-procedure delirium on resource utilization following transcatheter and surgical aortic valve replacement (TAVR and SAVR, respectively).

Background: Postprocedure delirium is associated with worse long-term survival after TAVR and SAVR. However, its effect on resource utilization has been understudied. Read More

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December 2018

The clinical value of automated office blood pressure: What is the latest evidence on attended vs unattended automated readings in clinical practice?

J Clin Hypertens (Greenwich) 2018 Dec 14. Epub 2018 Dec 14.

Cardiology Department, Georgetown University and Veterans Affairs Medical Center, Washington, District of Columbia.

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December 2018

Comparison of two different radiofrequency ablation systems for renal artery denervation: Evaluation of short-term and long-term follow up.

Catheter Cardiovasc Interv 2018 Dec 14. Epub 2018 Dec 14.

Department of Cardiology, Westmead Hospital, Sydney, New South Wales, Australia.

Objectives: To assess the clinical efficacy of renal artery denervation (RAD) in our center and to compare the efficacy of two different radiofrequency (RF) systems.

Background: Several systems are available for RF renal denervation. Whether there is a difference in clinical efficacy among various systems remains unknown. Read More

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December 2018

An update on the management and outcomes of cancer patients with severe aortic stenosis.

Catheter Cardiovasc Interv 2018 Dec 14. Epub 2018 Dec 14.

Department of Cardiology, The University of Texas MD Anderson Cancer Center, Houston, Texas.

Objectives: We compared the outcomes of aortic valve replacement (AVR) by transcatheter (TAVR) and surgical (SAVR) routes with those of optimal medical management in patients with cancer and severe aortic stenosis (AS).

Background: Cancer therapy requires optimal cardiac output; however, the treatment of AS in cancer patients is not established.

Methods: Cancer patients with severe AS during January 2009 through February 2018 at a large cancer center were identified. Read More

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December 2018

In-utero treatment of a large symptomatic rhabdomyoma with sirolimus.

Ultrasound Obstet Gynecol 2018 Dec 14. Epub 2018 Dec 14.

Department of Obstetrics and Gynaecology, Fetal Medicine Unit, Mount Sinai Hospital and University of Toronto, Toronto, Canada.

A healthy 27-year-old woman was referred to our hospital at 21 weeks gestation. Fetal echocardiography revealed multiple cardiac rhabdomyomas, with the largest lesion in the left ventricle measuring 10x5mm. This article is protected by copyright. Read More

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December 2018

Dysfunctional endothelial progenitor cells in patients with Hodgkin's lymphoma in complete remission.

Cancer Med 2018 Dec 13. Epub 2018 Dec 13.

Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

Background: Patients with a history of Hodgkin's lymphoma (HL) are at increased long-term risk of cardiovascular morbidity and mortality. Studies report an association between the pathophysiology of coronary artery disease (CAD) and levels of circulating endothelial progenitor cells (EPC), which play an essential role in vascular injury repair. The aim of the present study was to investigate the potential involvement of abnormal EPC level or function in the CAD risk of survivors of HL in remission. Read More

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December 2018

The -44 C/G (rs1800972) polymorphism of the β-defensin 1 is associated with increased risk of developing type 2 diabetes mellitus.

Mol Genet Genomic Med 2018 Dec 13. Epub 2018 Dec 13.

Department of Molecular Biology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico.

Background: The aim of this study was to establish the association of two polymorphisms of the β-defensin 1 gene (DEFB1, OMIM#602056) with the risk of developing type 2 diabetes mellitus (T2DM) in a group of Mexican patients.

Methods: The 5'UTR -20 G/A, and -44 C/G polymorphisms of DEFB1 gene were genotyped by 5' exonuclease TaqMan assays in a group of 252 patients with T2DM and 522 healthy control.

Results: Under dominant and additive models adjusted for the risk factors, the C allele of the -44 C/G polymorphism was associated with increased risk of T2DM (OR = 1. Read More

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December 2018

Left atrial appendage occlusion using a Watchman device in a transplanted heart with biatrial anastomosis.

Catheter Cardiovasc Interv 2018 Dec 13. Epub 2018 Dec 13.

Division of Cardiology, Department of Medicine, Rush University Medical Center, Chicago, Illinois.

A percutaneous left atrial appendage (LAA) occlusion using a Watchman device was performed in a patient with prior biatrial anastomosis orthotopic heart transplant (OHT). Due to the anatomical changes following biatrial anastomosis, transesophageal echocardiography (TEE) imaging and transseptal puncture become technically challenging. We describe how the standard LAA views on TEE were obtained for device sizing, and how the transseptal puncture was modified to cross the scarred septum. Read More

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December 2018

Safety outcomes of new versus old generation transcatheter aortic valves.

Catheter Cardiovasc Interv 2018 Dec 13. Epub 2018 Dec 13.

Cardiology department, Tel Aviv Sourasky Medical Center, Israel, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.

Objective: To compare procedural outcomes of transcatheter aortic valve implantation (TAVI) patients who were implanted with older versus newer generation valves.

Background: The current evidence base for improved safety of the newer commercially available TAVI valves is limited.

Methods: A retrospective analysis of the Israeli multicenter TAVI registry was performed. Read More

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December 2018

Optimal medical therapy vs. coronary revascularization for patients presenting with chronic total occlusion: A meta-analysis of randomized controlled trials and propensity score adjusted studies.

Catheter Cardiovasc Interv 2018 Dec 13. Epub 2018 Dec 13.

Department of Cardiology and Angiology II, University Heart Center Freiburg, Bad Krozingen, Germany.

Introduction: The optimal management of patients with coronary chronic total occlusions (CTO) remains controversial. This meta-analysis aims to compare percutaneous coronary intervention of CTO (CTO-PCI) versus optimal medical therapy (OMT) in CTO patients.

Methods: A literature search with highly specific terms was conducted using MEDLINE, EMBASE, and Web of Science to identify most relevant randomized controlled trials (RCTs) and observational studies with propensity score matching (PSM) evaluating differences in between CTO-PCI versus OMT. Read More

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December 2018
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An alternative treatment strategy for large vessel coronary perforations.

Catheter Cardiovasc Interv 2018 Dec 13. Epub 2018 Dec 13.

Minneapolis Heart Institute and Minneapolis Heart Institute Foundation, Abbott Northwestern Hospital, Minneapolis, Minnesota.

The standard treatment for large vessel coronary perforations is implantation of a covered stent. Antegrade attempts for crossing a right coronary artery chronic total occlusion resulted in guidewire and microcatheter exit with pericardial bleeding. A balloon was inflated proximal to the perforation site to achieve temporary hemostasis. Read More

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December 2018

Mineralocorticoid receptor deficiency improves the therapeutic effects of mesenchymal stem cells for myocardial infarction via enhanced cell survival.

J Cell Mol Med 2018 Dec 13. Epub 2018 Dec 13.

Shanghai Institute of Cardiovascular Disease, Zhongshan Hospital, Fudan University, Shanghai, People's Republic of China.

The poor survival of stem cells seriously limits their therapeutic efficacy for myocardial infarction (MI). Mineralocorticoid receptor (MR) activation plays an important role in the pathogenesis of multiple cardiovascular diseases. Here, we examined whether MR silencing in bone marrow derived mesenchymal stem cells (MSCs) could improve MSCs' survival and enhance their cardioprotective effects in MI. Read More

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December 2018

Defining a 'frequent admitter' phenotype among patients with repeat heart failure admissions.

Eur J Heart Fail 2018 Dec 13. Epub 2018 Dec 13.

National Heart Research Institute Singapore, National Heart Centre Singapore, Singapore.

Aims: We aimed to identify a 'frequent admitter' phenotype among patients admitted for acute decompensated heart failure (HF).

Methods And Results: We studied 10 363 patients in a population-based prospective HF registry (2008-2012), segregated into clusters based on their 3-year HF readmission frequency trajectories. Using receiver-operating characteristic analysis, we identified the index year readmission frequency threshold that most accurately predicts HF admission frequency clusters. Read More

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December 2018

Clinical investigation of esophageal injury from cryoballoon ablation of persistent atrial fibrillation.

Pacing Clin Electrophysiol 2018 Dec 14. Epub 2018 Dec 14.

Heart center, Japan Red Cross Yokohama City Bay Hospital, Yokohama City, Japan.

Background: The cryoballoon (CB) can be utilized for extra pulmonary vein (PV) ablation such as for a left atrial (LA) posterior wall (LAPW) isolation. However, scrutiny of the esophageal injuries during the LAPW isolation has never been performed. We sought to thoroughly investigate the esophageal lesions (ELs) and gastric hypomotility (GH) caused by an LAPW isolation using a CB. Read More

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December 2018

Regulation of Red Blood Cell Volume with Exercise Training.

Compr Physiol 2018 Dec 13;9(1):149-164. Epub 2018 Dec 13.

Center for Physical Activity Research, University Hospital Copenhagen, Denmark.

Hypervolemia is a hallmark of endurance training (ET) and manifests by similar elevations in plasma (PV) and red blood cell volume (RBCV) so that hematocrit largely remains unaltered following weeks/months of training. While the mechanisms facilitating PV expansion with ET have been previously reviewed extensively this is not the case for RBCV. Endurance champions may have 40% more RBCV than controls and RBCV may increase up to 10% following months of regular exercise training in healthy individuals. Read More

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December 2018

Gender differences in symptoms and functional status in patients with atrial fibrillation undergoing catheter ablation.

Pacing Clin Electrophysiol 2018 Dec 13. Epub 2018 Dec 13.

Chapel Hill: Department of Medicine, Division of Cardiology, University of North Carolina, 160 Dental Circle CB#7075, Chapel Hill, NC 27599, USA.

Background: Catheter ablation improves symptoms and quality of life in patients with atrial fibrillation (AF); however, despite its benefit, women are less likely than men to undergo catheter ablation. Women with AF have been described to have more frequent and severe symptoms with a lower quality of life than men, and it is therefore unclear why women are less likely to undergo catheter ablation. We prospectively characterized gender differences in AF symptoms among men and women undergoing ablation at UNC using questionnaire data. Read More

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December 2018

Implantable Cardioverter Defibrillator replacement guided by T wave safety margin in a short QT syndrome patient.

Pacing Clin Electrophysiol 2018 Dec 13. Epub 2018 Dec 13.

Department of Cardiology & Cardiovascular Research Institute, Renmin Hospital of Wuhan University, Wuhan, 430060, China.

We report ICD generator replacement guided by T wave safety margin (TWSM) in a short QT syndrome patient with T wave oversensing (TWOS). During the procedure of generator replacement, the feature of ventricular sensing in 4 different ICDs was compared in the patient. The 4 ICDs showed different R and T wave amplitudes. Read More

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December 2018

Conduction recovery following pacemaker implantation after transcatheter aortic valve replacement.

Pacing Clin Electrophysiol 2018 Dec 13. Epub 2018 Dec 13.

Division of Cardiology, Bluhm Cardiovascular Institute, Feinberg School of Medicine, Northwestern University, Chicago, IL.

Background: Transcatheter aortic valve replacement (TAVR) is increasingly used to treat severe aortic stenosis. A frequent complication of TAVR is high grade or complete atrioventricular (AV) block requiring a permanent pacemaker (PPM). There is little data on the long-term dependency on pacing after TAVR. Read More

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December 2018

The incredible effect of OSA surgery on blood pressure: Too good to be true?

Laryngoscope 2018 Dec 13. Epub 2018 Dec 13.

The Division of Cardiology, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, U.S.A.

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December 2018

Percutaneous patent foramen ovale closure during live case demonstrations.

Catheter Cardiovasc Interv 2018 Dec 12. Epub 2018 Dec 12.

Department of Cardiology, University Hospital of Bern, Bern, Switzerland.

Background: Live case demonstrations serve as an educational tool for interventional techniques in cardiology. The aim of this study was to assess the safety and technical success of percutaneous patent foramen ovale (PFO) closure during live case demonstrations.

Methods: All patients who had undergone percutaneous PFO closure with Amplatzer devices during live case demonstrations at our institution were consecutively included in this retrospective analysis. Read More

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December 2018

Impact of erythrocytapheresis on natural anticoagulant levels in children with sickle cell disease: A pilot study.

Pediatr Blood Cancer 2018 Dec 13:e27588. Epub 2018 Dec 13.

Department of Pediatrics, The Ohio State University, Division of Hematology/Oncology, Nationwide Children's Hospital, Columbus, Ohio.

Venous thromboembolism (VTE) is being increasingly recognized in children with sickle cell disease (SCD). In a retrospective cohort study, we identified bilateral central venous catheter (CVC) placement as an independent risk factor for VTE. At our institution, the only indication for bilateral CVC placement in children with SCD is erythrocytapheresis. Read More

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December 2018

Sex differences in 1-year mortality risks in older patients experiencing a first acute heart failure hospitalization.

Geriatr Gerontol Int 2018 Dec 12. Epub 2018 Dec 12.

Geriatric Unit, Internal Medicine Department, Bellvitge University Hospital-IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain.

Aim: To assess whether 1-year mortality in older patients experiencing a first admission for acute heart failure was related to sex, and to explore differential characteristics according to sex.

Methods: We reviewed the medical records of 1132 patients aged >70 years of age admitted within a 3-year period because of a first episode of acute heart failure. We analyzed sex differences. Read More

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December 2018

Interatrial septal fat thickness and left atrial stiffness are mechanistic links between nonalcoholic fatty liver disease and incident atrial fibrillation.

Echocardiography 2018 Dec 12. Epub 2018 Dec 12.

Cardiology Department, Zagazig University Hospital-Egypt, Zagazig, Egypt.

Background And Aim: Recently, a clear evidence suggests that nonalcoholic fatty liver disease (NAFLD) is associated with an increased risk of incident atrial fibrillation (AF). Yet, the underlying pathogenesis is speculative. Thereby, we aimed to investigate the hypothesis that, interatrial thickness (IAST) and left atrial stiffness (LASt) might have mechanistic links between NAFLD and AF. Read More

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December 2018

Hypertrophic cardiomyopathy with dynamic obstruction and high left ventricular outflow gradients associated with paradoxical apical ballooning.

Echocardiography 2018 Dec 12. Epub 2018 Dec 12.

Mount Sinai West, Icahn School of Medicine at Mount Sinai, New York City, New York.

Background: Acute left ventricular (LV) apical ballooning with normal coronary angiography occurs rarely in obstructive hypertrophic cardiomyopathy (OHCM); it may be associated with severe hemodynamic instability.

Methods, Results: We searched for acute LV ballooning with apical hypokinesia/akinesia in databases of two HCM treatment programs. Diagnosis of OHCM was made by conventional criteria of LV hypertrophy in the absence of a clinical cause for hypertrophy and mitral-septal contact. Read More

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December 2018

All the things that we should think about if we want to diagnose the long QT accurately.

Pacing Clin Electrophysiol 2018 Dec 12. Epub 2018 Dec 12.

Division of Arrhythmia and Electrophysiology, Department of Cardiology, University of Health Sciences, Yuksek Ihtisas Heart-Education and Research Hospital, Ankara, Turkey.

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December 2018

Successful Physical Rehabilitation After Placement of a SynCardia Total Artificial Heart.

Artif Organs 2018 Dec 13. Epub 2018 Dec 13.

Division of Pediatric Cardiology, Ann & Robert H. Lurie Children's Hospital of Chicago, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.

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December 2018

Cardiac resynchronization therapy improves myocardial conduction.

Pacing Clin Electrophysiol 2018 Dec 13. Epub 2018 Dec 13.

Department of Cardiovascular Diseases, Mayo Clinic, Rochester, MN, USA.

Background: Cardiac resynchronization therapy (CRT) reverses left ventricular remodeling and improves left ventricular systolic function. However, little is known about whether CRT improves ventricular conduction.

Objective: To determine the relationship between CRT response and QRS narrowing. Read More

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December 2018

Relationship between serum high sensitivity C-reactive protein with angiographic severity of coronary artery disease and traditional cardiovascular risk factors.

J Cell Physiol 2018 Dec 12. Epub 2018 Dec 12.

Department of Nutrition and Dietetics, Faculty of Medicine and Health Sciences, University Putra Malaysia, Malaysia.

Serum high-sensitivity C-reactive protein (hs-CRP) is predictive of coronary artery disease (CAD). The aim of this study was to examine the possible association of hs-CRP with presence and severity of CAD and traditional CAD risk factors. This case-control study was carried out on 2,346 individuals from September 2011 to May 2013. Read More

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December 2018

Downregulated microRNA-330 suppresses left ventricular remodeling via the TGF-β1/Smad3 signaling pathway by targeting SRY in mice with myocardial ischemia-reperfusion injury.

J Cell Physiol 2018 Dec 12. Epub 2018 Dec 12.

Department of Cardiology, Hunan Provincial People's Hospital (The First Affiliated Hospital of Hunan Normal University), Changsha, China.

microRNAs (miRs) are essential in the development of heart failure. The aim of this study is to investigate the effect of microRNA-330 (miR-330) on left ventricular remodeling via the TGF-β1/Smad3 signaling pathway by targeting the sex-determining region Y (SRY) in mice with myocardial ischemia-reperfusion injury (MIRI). Differentially expressed gene (DEG) in myocardial ischemia-reperfusion (IR) was screened out and the miR that targeted the DEG was also predicted and verified. Read More

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December 2018

Combinatorial Utilization of Murine Embryonic Stem Cells and In Vivo Models to Study Human Congenital Heart Disease.

Curr Protoc Stem Cell Biol 2018 Dec 12:e75. Epub 2018 Dec 12.

Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario, Canada.

We have established an in vitro model of the human congenital heart defect (CHD)-associated mutation NKX2.5 R141C. We describe the use of the hanging drop method to differentiate Nkx2. Read More

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December 2018

Hyperpolarized [1- C] pyruvate as a possible diagnostic tool in liver disease.

Physiol Rep 2018 Dec;6(23):e13943

MR Research Centre, Aarhus University Hospital, Aarhus, Denmark.

Introduction of hyperpolarized magnetic resonance in preclinical studies and lately translation to patients provides new detailed in vivo information of metabolic flux in organs. Hyperpolarized magnetic resonance based on C enriched pyruvate is performed without ionizing radiation and allows quantification of the pyruvate conversion products: alanine, lactate and bicarbonate in real time. Thus, this methodology has a promising potential for in vivo monitoring of energetic alterations in hepatic diseases. Read More

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December 2018

Effects of body position during cardiopulmonary exercise testing with right heart catheterization.

Physiol Rep 2018 Dec;6(23):e13945

Division of Cardiology, Department of Medicine, Kyorin University Hospital, Mitaka, Tokyo, Japan.

Cardiopulmonary exercise testing (CPX) with right heart catheterization (RHC) widely used for early diagnosis and evaluation of pulmonary vascular disease in patients with pulmonary arterial hypertension and early stage heart failure with preserved ejection fraction, who display normal hemodynamics at rest. The aim of this study was to investigate that whether body position affects pulmonary hemodynamics, pulmonary arterial wedge pressure (PAWP), and CPX parameters during invasive CPX. Seventeen patients (58 ± 14 years; 5/12 male/female) with chronic thromboembolic pulmonary hypertension treated with percutaneous transluminal pulmonary angioplasty and near-normal pulmonary artery pressure (PAP) underwent invasive CPX twice in supine and upright position using a cycle ergometer with 6 months interval. Read More

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December 2018

The milk thistle (Silybum marianum) compound Silibinin stimulates leukopoiesis from mouse embryonic stem cells.

Phytother Res 2018 Dec 11. Epub 2018 Dec 11.

Department of Physiology, Faculty of Medicine, Justus Liebig University Giessen, Giessen, Germany.

The milk thistle compound Silibinin (i.e., a 1:1 mixture of Silybin A and Silybin B) stimulates vasculogenesis of mouse embryonic stem (ES) cells. Read More

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December 2018

Quantification of rheumatic mitral stenosis severity with three-dimensional vena contracta area.

Echocardiography 2018 Dec 11. Epub 2018 Dec 11.

Department of Cardiology, Marmara University Medical Center, Istanbul, Turkey.

Introduction: Rheumatic mitral stenosis (MS) is an important health issue in developing countries. Assessment of the correct mitral valve area (MVA) is essential for the timing of intervention. Most of the parameters for the assessment of rheumatic MS are derived from Two-dimensional (2D) echocardiography. Read More

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December 2018