186 results match your criteria Cardiology and therapy[Journal]


Use, Persistence, Efficacy, and Safety of Apixaban in Patients with Non-Valvular Atrial Fibrillation in Unselected Patients in Germany. Results of the Prospective Apixaban in Atrial Fibrillation (APAF) Registry.

Cardiol Ther 2020 Jul 8. Epub 2020 Jul 8.

Kardiologische Praxisklinik Ludwigshafen, Ludwigshafen, Germany.

Introduction: Apixaban has been shown to be superior to warfarin in patients with non-valvular atrial fibrillation in the randomized ARISTOTLE trial and its use is recommended in current guidelines. There are only scarce data about its use, efficacy, and safety in unselected patients in Germany.

Methods And Results: The APAF registry is a prospective non-interventional study enrolling 5015 patients with non-valvular atrial fibrillation. Read More

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http://dx.doi.org/10.1007/s40119-020-00188-1DOI Listing

A Comparison of Ezetimibe and Evolocumab for Atherogenic Lipid Reduction in Four Patient Populations: A Pooled Efficacy and Safety Analysis of Three Phase 3 Studies.

Cardiol Ther 2020 Jun 20. Epub 2020 Jun 20.

Academic Medical Center of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam-Zuidoost, Amsterdam, The Netherlands.

Introduction: Clinicians, payers, guideline committees, and policymakers support the use of high-intensity statins in patients at high risk for complications of cardiovascular disease (CVD). Guidelines and recommendations provide guidance on next steps for patients with inadequate low-density lipoprotein cholesterol (LDL-C) control on maximally tolerated statin or for those who are statin-intolerant. Ezetimibe and evolocumab improve CV outcomes when added to statins in high-CV-risk populations. Read More

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http://dx.doi.org/10.1007/s40119-020-00181-8DOI Listing

Optical Coherence Tomography: Current Applications for the Assessment of Coronary Artery Disease and Guidance of Percutaneous Coronary Interventions.

Cardiol Ther 2020 Jun 20. Epub 2020 Jun 20.

Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands.

Introduction: Coronary angiography (CAG) is the standard modality for assessment of coronary stenoses and intraprocedural guidance of percutaneous coronary interventions (PCI). However, the limitations of CAG are well recognized. Intracoronary imaging (ICI) can potentially overcome these limitations. Read More

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http://dx.doi.org/10.1007/s40119-020-00185-4DOI Listing

Home-Based Cardiac Rehabilitation (HBCR) In Post-TAVR Patients: A Prospective, Single-Center, Cohort, Pilot Study.

Cardiol Ther 2020 Jun 13. Epub 2020 Jun 13.

University of Florida Health, Gainesville, FL, USA.

Introduction: Cardiac rehabilitation after transcatheter aortic valve replacement (TAVR) safely improves exercise tolerance, functional independence, and quality of life. However, barriers such as transportation, cost, and limited access to rehabilitation programs prohibits participation. In 2010, the Veterans Affairs Medical Center (VAMC) started a 12-week home-based cardiac rehabilitation (HBCR) program at 13 sites around the country to increase participation by reducing such barriers. Read More

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http://dx.doi.org/10.1007/s40119-020-00186-3DOI Listing

Cardiovascular Implications and Therapeutic Considerations in COVID-19 Infection.

Cardiol Ther 2020 Jun 13. Epub 2020 Jun 13.

Division of Cardiology, Department of Medicine, University of California, San Francisco, CA, USA.

The ongoing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has profoundly impacted all fields of medicine. Infection with SARS-CoV-2 and the resulting coronavirus of 2019 (COVID-19) syndrome has multiorgan effects. The pandemic has united researchers from bench to bedside in attempts to understand the pathophysiology of the disease and define optimal treatment strategies. Read More

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http://dx.doi.org/10.1007/s40119-020-00184-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7292941PMC

Extrapolation of Survival Benefits in Patients with Transthyretin Amyloid Cardiomyopathy Receiving Tafamidis: Analysis of the Tafamidis in Transthyretin Cardiomyopathy Clinical Trial.

Cardiol Ther 2020 Jun 10. Epub 2020 Jun 10.

Pfizer, Groton, CT, USA.

Introduction: In the Tafamidis in Transthyretin Cardiomyopathy Clinical Trial (ATTR-ACT; ClinicalTrials.gov number NCT01994889), tafamidis reduced the risk of all-cause mortality in patients with transthyretin amyloid cardiomyopathy (ATTR-CM) by 30% versus placebo. Median overall survival was not achieved in either treatment arm (57. Read More

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http://dx.doi.org/10.1007/s40119-020-00179-2DOI Listing

In-Hospital Outcomes of Patients with Acute Decompensated Heart Failure and Cirrhosis: An Analysis of the National Inpatient Sample.

Cardiol Ther 2020 Jun 8. Epub 2020 Jun 8.

Division of Gastroenterology, Jefferson Health New Jersey, New Jersey, USA.

Introduction: Heart failure increases morbidity and mortality in patients admitted for cirrhosis. Our objective was to determine if patients with acute decompensated heart failure (ADHF) and cirrhosis would have increased mortality, hospital length of stay (LOS), and total hospital charges compared to patients with only ADHF. There is also a paucity of data regarding the influence of gender, race, ethnicity, insurance, and cirrhosis-related complications on mortality, hospital length of stay, and total hospitalization charges. Read More

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http://dx.doi.org/10.1007/s40119-020-00183-6DOI Listing

Anatomical Extent of Venous Reflux.

Authors:
Fedor Lurie

Cardiol Ther 2020 Jun 2. Epub 2020 Jun 2.

Department of Vascular Surgery, Promedica Jobst Vascular Institute, Toledo, OH, USA.

Despite the recognition of the importance of the anatomical extent of venous reflux, its description in medical literature is inconsistent in terms and classifications. Recent international consensus documents provide clear definitions for the three main classes of reflux: segmental, multi-segmental, and axial. This report addresses the most important aspects of the standard definitions of the anatomical extent of venous reflux, the differences between the three classes of reflux, and the challenges of implementing this classification in clinical practice. Read More

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http://dx.doi.org/10.1007/s40119-020-00182-7DOI Listing

A Qualitative Analysis of Patient-Related Factors Associated With Implantable Cardioverter Defibrillator Acceptance.

Cardiol Ther 2020 May 31. Epub 2020 May 31.

Internal Medicine and Psychiatry, University of Pittsburgh, and Center for Health Equity Research and Promotion, Veterans Affairs Pittsburgh Healthcare System, Pittsburgh, PA, USA.

Introduction: Patient-related factors determining implantable cardioverter-defibrillator (ICD) use for primary prevention of sudden cardiac death in patients with cardiomyopathy have not been well explored. To assess race and sex differences regarding ICD preferences in this patient population, we sought to analyze a diverse cohort of patients with heart failure (HF) with reduced ejection fraction.

Methods: We conducted qualitative interviews of 28 adults with severe HF and either (1) an ICD or (2) no ICD. Read More

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http://dx.doi.org/10.1007/s40119-020-00180-9DOI Listing

Acute Myocarditis After Black Widow Spider Bite: A Case Report.

Cardiol Ther 2020 May 27. Epub 2020 May 27.

Cardiology Unit, Hospital "Madonna Delle Grazie", Matera Local Health Authority (ASL Matera), Matera, MT, Italy.

The black widow spider (BWS) is a venomous spider whose bite can cause various clinical conditions that range from local damage to serious systemic complications, including death. Cases of myocarditis following a BWS bite are rare but they can be fatal on occasion. However, the prognostic significance of the bite and presentation of myocarditis is unknown. Read More

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http://dx.doi.org/10.1007/s40119-020-00178-3DOI Listing

Perceptions and Experiences of Atrial Fibrillation Patients on Their Condition and Oral Anticoagulant Treatment.

Cardiol Ther 2020 May 27. Epub 2020 May 27.

MedScope, Leeghwaterstraat 19, 2012 GD, Haarlem, The Netherlands.

Introduction: This study was designed to gain insight into the treatment experiences and expectations of patients with atrial fibrillation (AF) who were treated with vitamin K antagonists (VKA) or recently switched from VKA treatment to direct oral anticoagulant (DOAC) therapy. Little is known about the perceptions and expectations of patients with AF who are being prescribed oral anticoagulants (OACs), leading to different expectations of patient and doctor of their respective roles in disease management between the doctor [general practitioner (GP) or cardiologist] and patient on their respective roles in disease management.

Methods: A market research study was conducted consisting of two phases: (1) qualitative research (n = 16) in which in-depth interviews were conducted; and (2) quantitative research (n = 101), using a conjoint analysis. Read More

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http://dx.doi.org/10.1007/s40119-020-00173-8DOI Listing

Lipoprotein(a) and Cardiovascular Disease Prevention across Diverse Populations.

Cardiol Ther 2020 May 25. Epub 2020 May 25.

Division of Cardiovascular Medicine and the Cardiovascular Institute, Stanford University, Stanford, USA.

Lipoprotein(a) (Lp(a)) is a highly proatherogenic lipid fraction that is genetically determined and minimally responsive to lifestyle or behavior changes. Mendelian randomization studies have suggested a causal link between elevated Lp(a) and heart disease, stroke, and aortic stenosis. There is substantial inter-ethnic variation in Lp(a) levels, with persons of African descent having the highest median values. Read More

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http://dx.doi.org/10.1007/s40119-020-00177-4DOI Listing

Sex-Based Differences in Coronary and Structural Percutaneous Interventions.

Cardiol Ther 2020 May 21. Epub 2020 May 21.

Division of Cardiovascular Medicine, University of Florida, Gainesville, FL, USA.

In the current state of interventional cardiology, the ability to offer advanced therapies to patients who historically were not surgical candidates has grown exponentially in the last few decades. As therapies have expanded in complex coronary and structural interventions, the nuances of treating certain populations have emerged. In particular, the role of sex-based anatomic and outcome differences has been increasingly recognized. Read More

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http://dx.doi.org/10.1007/s40119-020-00176-5DOI Listing

Effectiveness of Trimetazidine in Patients with Stable Angina Pectoris of Various Durations: Results from ODA.

Cardiol Ther 2020 May 19. Epub 2020 May 19.

Laboratory of Biostatistics, National Medical Research Center for Preventive Medicine of the Ministry of Healthcare, Moscow, Russia.

Introduction: Trimetazidine (TMZ) is an antianginal agent that acts directly at the myocardial cell level and which is now available in a once-daily (od) formulation.

Methods: ODA, a 3-month, observational, multicenter study in Russia, assessed the effectiveness and tolerability of TMZ 80 mg od in patients with stable angina and persisting symptoms, in real-life settings. The present analysis explored the effects of adding TMZ to background antianginal treatment with respect to the duration of stable angina. Read More

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http://dx.doi.org/10.1007/s40119-020-00174-7DOI Listing

The Physiologic Basis and Clinical Outcomes of Combined Impella and Veno-Arterial Extracorporeal Membrane Oxygenation Support in Cardiogenic Shock.

Authors:
Hoong Sern Lim

Cardiol Ther 2020 May 18. Epub 2020 May 18.

University Hospital Birmingham, Edgbaston, Birmingham, UK.

Veno-arterial extracorporeal membrane oxygenation (VA-ECMO) provides effective hemodynamic support in cardiogenic shock, but in some cases may be complicated by left ventricular (LV) distension and pulmonary edema. The Impella, a catheter-mounted microaxial pump has been used to unload the LV. Recent studies have compared the clinical outcomes of VA-ECMO to the combination of Impella and VA-ECMO. Read More

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http://dx.doi.org/10.1007/s40119-020-00175-6DOI Listing

Incidence Rates of Bleeding and Emergency Surgery Due to Trauma or Fracture Among Japanese Patients with Non-valvular Atrial Fibrillation Receiving Oral Anticoagulation Therapy.

Cardiol Ther 2020 Jun 11;9(1):189-199. Epub 2020 May 11.

Nippon Boehringer Ingelheim, 2-1-1 Osaki, Shinagawa-ku, Tokyo, 141-6017, Japan.

Introduction: In patients with nonvalvular atrial fibrillation (NVAF) receiving oral anticoagulants (OACs), reversal of coagulopathy can be achieved with specific reversal drugs such as idarucizumab, which is indicated for use in patients treated with dabigatran for cases of life-threatening or uncontrolled bleeding or during emergency procedures that may cause serious bleeding. This study examined the incidence rate (IR) of emergency surgeries and major bleeding episodes associated with fractures and trauma in Japanese patients with NVAF receiving OACs.

Methods: This retrospective, non-interventional analysis of health insurance claims was conducted using data from 62,888 OAC-naive adult patients with NVAF who initiated dabigatran, warfarin, apixaban, rivaroxaban, or edoxaban between March 2011 and June 2016. Read More

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http://dx.doi.org/10.1007/s40119-020-00171-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7237605PMC

Proposal for New Classification and Practical Use of Diuretics According to Their Effects on the Serum Chloride Concentration: Rationale Based on the "Chloride Theory".

Authors:
Hajime Kataoka

Cardiol Ther 2020 May 6. Epub 2020 May 6.

Internal Medicine, Nishida Hospital, Oita, Japan.

Currently, diuretic therapy for heart failure (HF) pathophysiology is primarily focused on the sodium and water balance. Over the last several years, however, chloride (Cl) has been recognized to have an important role in HF pathophysiology, as both a prognostic marker and a possible central factor regulating the body fluid status. I recently proposed a unifying hypothesis for HF pathophysiology, called the "chloride theory", during HF worsening and recovery, as follows. Read More

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http://dx.doi.org/10.1007/s40119-020-00172-9DOI Listing

Prevalence of US Adults with Triglycerides ≥ 150 mg/dl: NHANES 2007-2014.

Cardiol Ther 2020 Jun 23;9(1):207-213. Epub 2020 Apr 23.

Heart Disease Prevention Program, Division of Cardiology, University of California, Irvine, Irvine, CA, USA.

Introduction: Hypertriglyceridemia is associated with increased atherosclerotic cardiovascular disease (ASCVD) event risk, which persists even in statin-treated patients. The objective of this analysis was to estimate the prevalence of triglyceride (TG) levels ≥ 150 mg/dl in statin-treated adults with diabetes or ASCVD in the United States.

Methods: Laboratory data, medical history, and prescription data from 40,617 subjects who participated in the US National Health and Nutrition Examination Survey (NHANES) spanning 8 years (four 2-year surveys; 2007-2014) were analyzed. Read More

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http://dx.doi.org/10.1007/s40119-020-00170-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7237595PMC

Diagnosis of Transthyretin Amyloid Cardiomyopathy.

Cardiol Ther 2020 Jun 7;9(1):85-95. Epub 2020 Apr 7.

Division of Cardiovascular Medicine, University of Florida, Gainesville, FL, USA.

Transthyretin amyloid cardiomyopathy (ATTR-CM) continues to be an easily overlooked, life-threatening, yet treatable cause of heart failure. Furthermore, its elusive diagnosis leads to late or misdiagnosis. As therapeutic advancements such as tafamidis usher in a promising new era in the management of ATTR-CM, the need for disease awareness and efficient diagnostic evaluation is crucial. Read More

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http://dx.doi.org/10.1007/s40119-020-00169-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7237598PMC

Idarucizumab for Emergency Reversal of Anticoagulant Effects of Dabigatran: Interim Results of a Japanese Post-Marketing Surveillance Study.

Cardiol Ther 2020 Jun 9;9(1):167-188. Epub 2020 Mar 9.

Medicine Division, Nippon Boehringer Ingelheim Co, Ltd., Tokyo, Japan.

Introduction: Idarucizumab, a monoclonal antibody fragment, was developed to reverse the anticoagulant effect of dabigatran, and it was approved in Japan in September 2016. An all-case post-marketing surveillance is ongoing to collect data in Japanese patients treated with idarucizumab who had serious bleeding (Group A) or required an urgent procedure (Group B).

Methods: The primary endpoint was the incidence of adverse drug reactions (ADRs). Read More

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http://dx.doi.org/10.1007/s40119-020-00165-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7237558PMC

Cardiology and Therapy: A Summary of 2019 and Key Areas of Emerging Research in 2020.

Cardiol Ther 2020 Jun 6;9(1):1-4. Epub 2020 Mar 6.

Klinikum der Stadt Ludwigshafen, Ludwigshafen Am Rhein, Germany.

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http://dx.doi.org/10.1007/s40119-020-00166-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7237597PMC

Emergency Department Visits and Subsequent Hospital Admission Trends for Patients with Chest Pain and a History of Coronary Artery Disease.

Cardiol Ther 2020 Jun 2;9(1):153-165. Epub 2020 Mar 2.

Department of Emergency Medicine, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Neville House Second Floor, Boston, MA, 02115, USA.

Introduction: Hospitalization is the largest component of health care spending in the United States. Most hospitalized patients first visit the emergency department (ED), where hospitalization decisions are made. Optimal utilization of hospital resources is critical for all stakeholders. Read More

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http://dx.doi.org/10.1007/s40119-020-00168-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7237631PMC

Update on Transcatheter Aortic Valve Replacement.

Cardiol Ther 2020 Jun 28;9(1):75-84. Epub 2020 Feb 28.

Division of Cardiovascular Medicine, University of Florida, Gainesville, FL, USA.

Transcatheter aortic valve replacement (TAVR) is a minimally invasive approach to treat symptomatic severe aortic stenosis. The patient populations that have been shown to benefit from this procedure continue to grow with time. Techniques and technology in TAVR persistently advance with a continued trend toward improved outcomes for patients. Read More

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http://dx.doi.org/10.1007/s40119-020-00167-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7237626PMC

What Lessons Have We Learned and What Remains to be Clarified for PCSK9 Inhibitors? A Review of FOURIER and ODYSSEY Outcomes Trials.

Cardiol Ther 2020 Jun 5;9(1):59-73. Epub 2020 Feb 5.

TIMI Study Group, Brigham and Women's Hospital, Boston, MA, USA.

For more than half a century, low-density lipoprotein cholesterol (LDL-C) has been recognized as a major risk factor for incident atherosclerotic cardiovascular disease. The discovery of proprotein convertase subtilisin-kexin type 9 (PCSK9) in 2003, which prevents LDL-C receptor recycling, identified a new target for drug intervention. Recently, two large-scale randomized clinical outcomes trials involving fully human anti-PCSK9 monoclonal antibodies tested the hypothesis that targeting this pathway would reduce cardiovascular events. Read More

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http://dx.doi.org/10.1007/s40119-020-00163-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7237602PMC

Antihypertensive Effectiveness of Perindopril Arginine and Indapamide Single-Pill Combination According to Body Mass Index: Findings from the FORSAGE Study.

Authors:
M G Glezer

Cardiol Ther 2020 Jun 1;9(1):139-152. Epub 2020 Feb 1.

Department of Preventive and Emergency Cardiology, Sechenov First Moscow State Medical University, Moscow, Russia.

Introduction: Overweight and obesity are increasing worldwide and are associated with an increased risk for cardiovascular disease (CVD). The aim of this study was to examine the burden of CVD risk factors among normal weight, overweight, and obese subjects with hypertension, and to evaluate the effectiveness of switching to a single-pill combination (SPC) of perindopril arginine/indapamide for blood pressure (BP) control in overweight and obese subjects treated in routine clinical practice.

Methods: FORSAGE was a 3-month, multicenter, observational, open-label study conducted in Russian patients with uncontrolled arterial hypertension under previous antihypertensive therapy. Read More

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http://dx.doi.org/10.1007/s40119-020-00162-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7237592PMC

The Beneficial Effects of Cardiac Rehabilitation.

Cardiol Ther 2020 Jun 29;9(1):35-44. Epub 2020 Jan 29.

MEDIAN AGZ Düsseldorf, Düsseldorf, Germany.

Cardiac rehabilitation (CR) is a combined range of measures aimed at providing patients with cardiovascular disease with the optimum psychological and physical conditions so that they themselves can prevent their disease from progressing or potentially reversing its course. The following measures are the three main parts of CR: exercise training, lifestyle modification, and psychological intervention. The course of cardiac rehabilitation generally takes 3-4 weeks. Read More

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http://dx.doi.org/10.1007/s40119-020-00164-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7237601PMC

Relationship between Invasive and Echocardiographic Transvalvular Gradients after Transcatheter Aortic Valve Replacement.

Cardiol Ther 2020 Jun 22;9(1):201-206. Epub 2020 Jan 22.

Department of Medicine, University of Florida, Gainesville, FL, USA.

Introduction: Lower transcatheter aortic valve replacement (TAVR) pressure gradients have been reported after implantation of self-expanding valves compared with balloon-expandable valves; however, there is a paucity of data on the relationship between invasively measured transvalvular pressure gradients and Doppler-derived measurements.

Methods: From September 2013 to September 2018, patients with native aortic valve stenosis who had both intraoperative invasive and postoperative echocardiography transvalvular pressure gradients were included for analysis. We used parametric and nonparametric statistics to compare aortic gradients within and between groups. Read More

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http://dx.doi.org/10.1007/s40119-020-00161-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7237565PMC

Diagnosis of Amyloidosis: A Survey of Current Awareness and Clinical Challenges Among Cardiologists in Switzerland.

Authors:
Dennis Mircsof

Cardiol Ther 2020 Jun 20;9(1):127-138. Epub 2020 Jan 20.

Pfizer AG, Zurich, Switzerland.

Introduction: Transthyretin amyloidosis (ATTR) is a progressive disease in which amyloid fibril deposition disrupts tissue structure and organ function. Many patients with ATTR present with cardiac involvement; recent studies indicate that ATTR prevalence is higher than expected in patients with certain heart conditions. Although long delays to diagnosis are common, recent treatment advances have made timely diagnosis critical to ensure appropriate patient management. Read More

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http://dx.doi.org/10.1007/s40119-019-00160-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7237604PMC

Facing the Challenge of Lowering Blood Pressure and Cholesterol in the Same Patient: Report of a Symposium at the European Society of Hypertension.

Cardiol Ther 2020 Jun 13;9(1):19-34. Epub 2020 Jan 13.

Department of Nephrology and Hypertension, University Hospital Erlangen, Friedrich Alexander University Erlangen Nuremberg, Erlangen, Germany.

A symposium held at the 29th European Meeting on Hypertension and Cardiovascular Protection in Milan, Italy, discussed the potential impact and long-term benefits of early active management of cardiovascular disease (CVD) risk in patients with hypertension, and potential barriers to this strategy. Hypertension often aggregates with other cardiovascular risk factors, exponentially increasing morbidity and mortality. While effective therapies to treat hypertension exist, a substantial number of patients still experience major cardiovascular events. Read More

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http://dx.doi.org/10.1007/s40119-019-00159-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7237547PMC

Catheter Ablation of Atrial Fibrillation: State of the Art and Future Perspectives.

Cardiol Ther 2020 Jun 2;9(1):45-58. Epub 2020 Jan 2.

Universitäres Herzzentrum Hamburg-Eppendorf, Hamburg, Germany.

Purpose Of Review: Atrial fibrillation (AF), the most common sustained arrhythmia, is associated with high rates of morbidity and mortality. Maintenance of stable sinus rhythm (SR) is the intended treatment target in symptomatic patients, and catheter ablation aimed at isolating the pulmonary veins provides the most effective treatment option, supported by encouraging clinical outcome data. A variety of energy sources and devices have been developed and evaluated. Read More

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http://dx.doi.org/10.1007/s40119-019-00158-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7237603PMC

Mitraclip Plus Medical Therapy Versus Medical Therapy Alone for Functional Mitral Regurgitation: A Meta-Analysis.

Cardiol Ther 2020 Jun 9;9(1):5-17. Epub 2019 Dec 9.

Department of Cardiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Introduction: The purpose of this meta-analysis is to compare the efficacy of MitraClip plus medical therapy versus medical therapy alone in patients with functional mitral regurgitation (FMR). FMR caused by left ventricular dysfunction is associated with poor prognosis. Whether MitraClip improves clinical outcomes in this patient population remains controversial. Read More

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http://dx.doi.org/10.1007/s40119-019-00157-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7237594PMC

Effect of Methadone on Cardiac Repolarization in Japanese Cancer Patients: A Longitudinal Study.

Cardiol Ther 2020 Jun 20;9(1):119-126. Epub 2019 Nov 20.

Department of Anesthesiology, School of Medicine, Dokkyo Medical University, Kitakobayashi 880, Mibu, Tochigi, 321-0293, Japan.

Introduction: Methadone is known to prolong the QT interval, which could induce lethal arrhythmias such as torsades de pointes. To determine the risk of ventricular arrhythmias in cancer patients using methadone, we measured QT dispersion (QTD) and Tpeak-Tend (TpTe) before and after methadone administration and evaluated the correlations between methadone dosage and cardiac repolarization.

Methods: We conducted a retrospective observational study with 19 patients undergoing follow-up for cancer pain with methadone. Read More

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http://dx.doi.org/10.1007/s40119-019-00156-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7237557PMC

Comparative Outcomes of Transapical Versus Transfemoral Access for Transcatheter Aortic Valve Replacement in Diabetics.

Cardiol Ther 2020 Jun 11;9(1):107-118. Epub 2019 Nov 11.

Department of Cardiovascular Medicine, University of Texas Medical Branch, Galveston, TX, USA.

Introduction: The outcomes of transfemoral (TF) compared with transapical (TA) access for transcatheter aortic valve replacement (TAVR) in diabetics are unknown.

Methods: We queried the NIS database (2011-2014) to identify diabetics who underwent TAVR. We performed a propensity matching analysis comparing TF-TAVR versus TA-TAVR. Read More

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http://dx.doi.org/10.1007/s40119-019-00155-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7237629PMC

Comparison of Cardiac Repolarization After Transcatheter Aortic Valve Implantation and Surgical Aortic Valve Replacement: A Longitudinal Study.

Cardiol Ther 2020 Jun 6;9(1):97-105. Epub 2019 Nov 6.

Department of Anesthesiology, School of Medicine, Dokkyo Medical University, Kitakobayashi 880, Mibu, Tochigi, 321-0293, Japan.

Introduction: Transcatheter aortic valve implantation (TAVI) has been established as an alternative to surgical aortic valve replacement (SAVR) for high-risk patients. To assess the impact of TAVI on cardiac repolarization, we compared QT dispersion (QTD) and the interval from the peak to the end of the T wave (Tpeak-Tend: TpTe) between the patients who underwent TAVI and those who underwent SAVR and TpTe between the patients who underwent TAVI or SAVR.

Methods: This retrospective study was approved by the ethics committee of Dokkyo Medical University Hospital. Read More

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http://dx.doi.org/10.1007/s40119-019-00154-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7237665PMC
June 2020
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Complications of Temporary Percutaneous Mechanical Circulatory Support for Cardiogenic Shock: An Appraisal of Contemporary Literature.

Cardiol Ther 2019 Dec 23;8(2):211-228. Epub 2019 Oct 23.

Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, USA.

Cardiogenic shock (CS) is associated with hemodynamic compromise and end-organ hypoperfusion due to a primary cardiac etiology. In addition to vasoactive medications, percutaneous mechanical circulatory support (MCS) devices offer the ability to support the hemodynamics and prevent acute organ failure. Despite the wide array of available MCS devices for CS, there are limited data on the complications from these devices. Read More

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http://dx.doi.org/10.1007/s40119-019-00152-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6828896PMC
December 2019

A Review of Antithrombotic Treatment in Critical Limb Ischemia After Endovascular Intervention.

Cardiol Ther 2019 Dec 19;8(2):193-209. Epub 2019 Oct 19.

Division of Cardiology, The Brooklyn Hospital Center, Brooklyn, NY, USA.

Endovascular intervention is often used to treat critical limb ischemia (CLI). Post-intervention treatment with antiplatelet and/or anticoagulant therapy has reduced morbidity and mortality due to cardiovascular complications. The purpose of this review is to shed light on the various pharmacologic treatment protocols for treating CLI following endovascular procedures. Read More

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http://dx.doi.org/10.1007/s40119-019-00153-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6828854PMC
December 2019
1 Read

Electrocardiographic Detection of Left Ventricular Hypertrophy; Adding Body Mass Index and Spatial QRS-T Angle: A Cross-Sectional Study.

Cardiol Ther 2019 Dec 16;8(2):345-356. Epub 2019 Oct 16.

Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands.

Introduction: We investigated improvement of electrocardiographic LVH detection by adding measures of adiposity and/or novel electrocardiographic measures. Left ventricular hypertrophy (LVH) is an important risk factor for adverse cardiovascular outcomes. Improvement of electrocardiographic criteria for LVH is desirable, since electrocardiography is widely used. Read More

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http://dx.doi.org/10.1007/s40119-019-00151-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6828905PMC
December 2019
1 Read

Losartan for Preventing Aortic Root Dilatation in Patients with Marfan Syndrome: A Meta-Analysis of Randomized Trials.

Cardiol Ther 2019 Dec 13;8(2):365-372. Epub 2019 Oct 13.

Department of Medicine, Division of Cardiology, University of Virginia, Charlottesville, VA, USA.

Introduction: The role of losartan in preventing aortic root dilatation in Marfan syndrome has been evaluated in many clinical trials; however, the results are conflicting.

Methods: We performed a computerized search of MEDLINE, EMBASE and COCHRANE databases through February 2019 for randomized clinical trials evaluating the effect of losartan in patients with Marfan syndrome. The main outcome was the change in the aortic root diameter in the losartan versus control groups. Read More

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http://dx.doi.org/10.1007/s40119-019-00149-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6828927PMC
December 2019
2 Reads

A Review of the Role of Bradykinin and Nitric Oxide in the Cardioprotective Action of Angiotensin-Converting Enzyme Inhibitors: Focus on Perindopril.

Cardiol Ther 2019 Dec 1;8(2):179-191. Epub 2019 Oct 1.

University of Liège Hospital, GIGA Cardiovascular Sciences, Division of Cardiology, Acute Care Unit, Heart Failure Clinic, CHU Sart Tilman, Liège, Belgium.

The functional integrity of the endothelium is essential for vascular health. In addition to maintaining a delicate balance between vasodilation and vasoconstriction, the endothelium has numerous other complex roles involved in the maintenance of vascular homeostasis. Chronic exposure to cardiovascular risk factors and oxidative stress results in an imbalance in these functions, creating an environment that favors reduced vasodilation and a proinflammatory and prothrombic state. Read More

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http://dx.doi.org/10.1007/s40119-019-00150-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6828891PMC
December 2019

Current Evidence on Oral Antibiotics for Infective Endocarditis: A Narrative Review.

Cardiol Ther 2019 Dec 18;8(2):167-177. Epub 2019 Sep 18.

Division of Infectious Diseases, Department of Internal Medicine, University of Iowa Hospitals and Clinics, Iowa City, IA, USA.

Infective endocarditis (IE) continues to be associated with high morbidity and mortality, even when treated with optimal antibiotic regimens. The selection of treatment depends on the causative pathogen, its antibiotic susceptibility profile, local and systemic complications and the presence of prosthetic materials or devices. Standard therapy typically involves 4-6 weeks of intravenous (IV) bactericidal therapy. Read More

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http://dx.doi.org/10.1007/s40119-019-00148-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6828890PMC
December 2019
4 Reads

Cardiovascular Risk Factors and Secondary Events Among Acute and Chronic Stable Myocardial Infarction Patients: Findings from a Managed Care Database.

Cardiol Ther 2019 Dec 20;8(2):329-343. Epub 2019 Aug 20.

Department of Medicine, Stanford Center for Clinical Research, Stanford University School of Medicine, Stanford, CA, USA.

Introduction: Long-term risk for recurrent cardiovascular events among myocardial infarction (MI) patients in the acute versus chronic stable phase is not well characterized. This study was conducted to evaluate risk factors associated with all-cause mortality and cardiovascular (CVD) morbidity and to determine the transition period from the acute to chronic stable phase of disease.

Methods: Administrative claims data from a managed care database (2007-2012) were linked to the Social Security Death Index. Read More

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http://dx.doi.org/10.1007/s40119-019-00147-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6828898PMC
December 2019
2 Reads

Effectiveness and Impact on Adherence of a New Fixed-Dose Combination of Ivabradine and Metoprolol in a Wide Range of Stable Angina Patients in Real-Life Practice.

Cardiol Ther 2019 Dec 13;8(2):317-328. Epub 2019 Aug 13.

Department of Medical Affairs, Servier Deutschland GmbH, Elsenheimerstrasse 53, 80687, Munich, Germany.

Introduction: The antianginal effectiveness of ivabradine administration in addition to beta-blockers has been shown in patients with stable angina. The first fixed-dose combination (FDC) of ivabradine and metoprolol is now available and its evaluation in various stable angina patient populations relevant to clinical practice would be useful.

Methods: In this 4-month, prospective, multicenter, observational study, the effectiveness and tolerability of the metoprolol/ivabradine FDC was assessed in patient subgroups specified according to age, coronary artery disease (CAD) duration, Canadian Cardiovascular Society (CCS) class, co-morbidities, and previous myocardial infarction (MI) or revascularization. Read More

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http://dx.doi.org/10.1007/s40119-019-00145-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6828913PMC
December 2019

Estimating the Prevalence of Transthyretin Amyloid Cardiomyopathy in a Large In-Hospital Database in Japan.

Cardiol Ther 2019 Dec 2;8(2):297-316. Epub 2019 Aug 2.

Department of Clinical Epidemiology and Health Economics, School of Public Health, University of Tokyo, Tokyo, Japan.

Introduction: Transthyretin amyloid cardiomyopathy (ATTR-CM)-a debilitating, fatal disease resulting from the deposition of transthyretin (TTR) amyloid fibrils-can be hereditary due to mutations in the TTR gene (ATTRm) or wild type (ATTRwt). The global prevalence of ATTR-CM is largely unknown, although likely underestimated, with no formal epidemiological prevalence studies in Japan. This study aimed to estimate the prevalence of ATTR-CM in a large in-hospital database in Japan. Read More

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http://dx.doi.org/10.1007/s40119-019-0142-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6828925PMC
December 2019
3 Reads

Patient-Reported Satisfaction and Study Drug Discontinuation: Post-Hoc Analysis of Findings from ROCKET AF.

Cardiol Ther 2019 Dec 2;8(2):283-295. Epub 2019 Aug 2.

Stanford Center for Clinical Research, Stanford University School of Medicine, Stanford, CA, USA.

Introduction: Patient-reported outcomes (PROs) and satisfaction endpoints are increasingly important in clinical trials and may be associated with treatment adherence. In this post hoc substudy from ROCKET AF, we examined whether patient-reported satisfaction was associated with study drug discontinuation.

Methods: ROCKET AF (n = 14,264) compared rivaroxaban with warfarin for prevention of stroke and systemic embolism in patients with atrial fibrillation. Read More

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http://dx.doi.org/10.1007/s40119-019-00146-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6828909PMC
December 2019
3 Reads

New American and European Hypertension Guidelines, Reconciling the Differences.

Cardiol Ther 2019 Dec 30;8(2):157-166. Epub 2019 Jul 30.

Hypertension Unit, Department of Internal Medicine, Hospital Mútua Terrassa, University of Barcelona, Barcelona, Spain.

In November 2017, the American College of Cardiology and the American Heart Association released hypertension guidelines for the first time, replacing the Joint National Committee periodical reports, appearing from 1977 to 2003. In parallel, the European Society of Cardiology and the European Society of Hypertension updated their own recommendations with a new document released in August 2018. While both documents contain similar recommendations concerning several aspects of detection, prevention, and management of hypertension, they differ in some sensitive characteristics, which specifically affect diagnostic and therapeutic aspects. Read More

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http://dx.doi.org/10.1007/s40119-019-0144-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6828883PMC
December 2019

Acute and Long-Term Outcomes of Patients with Impaired Left Ventricular Systolic Function Undergoing Rotational Atherectomy: A Single-Center Observational Retrospective Study.

Cardiol Ther 2019 Dec 27;8(2):267-281. Epub 2019 Jul 27.

The Heart Center, Segeberger Kliniken (Academic Teaching Hospital of the Universities of Kiel, Lübeck, and Hamburg), Bad Segeberg, Germany.

Introduction: Rotational atherectomy (RA) historically was contraindicated in patients with impaired left ventricular (LV) function due to inherent cardio-depressive effects. Contemporary RA practice is less aggressive than traditional RA and no longer withheld from patients with reduced ejection fraction (EF). The aim of this analysis is to explore the outcomes of rotational atherectomy (RA) in patients with reduced left ventricular ejection fraction (LVEF). Read More

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http://dx.doi.org/10.1007/s40119-019-0143-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6828855PMC
December 2019
5 Reads

Implications of Left Bundle Branch Block in Takotsubo Cardiomyopathy: Propensity Match Analysis from the National Inpatient Sample.

Cardiol Ther 2019 Dec 17;8(2):253-265. Epub 2019 Jul 17.

University of Michigan, 500 S State St, Ann Arbor, MI, 48109, USA.

Introduction: Takotsubo cardiomyopathy (TTC), also called stress cardiomyopathy, is a transient reversible left ventricular dysfunction mimicking acute coronary syndrome (ACS). Studies have shown similar rates of in-hospital complications in TTC and myocardial infarction (MI). Left bundle branch block (LBBB) is associated with increased mortality in patients with MI; however, similar studies comparing outcomes of TTC in the presence of LBBB are lacking. Read More

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http://dx.doi.org/10.1007/s40119-019-0141-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6828991PMC
December 2019
11 Reads

TRimetazidine as an Agent to affeCt clopidogrEl Response: The TRACER Study.

Cardiol Ther 2019 Jul 10:229-237. Epub 2019 Jul 10.

Cardiovascular Research Institute of Vermont, Colchester, VT, USA.

Introduction: This prospective study aimed to determine whether trimetazidine (TMZ) alters the pharmacodynamic (PD) effects of clopidogrel.

Methods: Patients with stable coronary artery disease (SCAD) (n = 24) who were actively treated with dual antiplatelet therapy (DAPT) of aspirin 81 mg daily and clopidogrel 75 mg daily were recruited. Platelet function was measured with the VerifyNow P2Y12 assay (Accriva Diagnostics, San Diego, CA, USA) and assessed before the initiation of and after 14 days of treatment with TMZ. Read More

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http://dx.doi.org/10.1007/s40119-019-0139-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6828882PMC
July 2019
25 Reads

Insulin Resistance is Associated with Longitudinal Changes of Cardiac Repolarization Heterogeneity in Apparently Healthy Subjects.

Cardiol Ther 2019 Jul 4:239-251. Epub 2019 Jul 4.

Department of Cardiovascular, Renal and Metabolic Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan.

Introduction: Increased heterogeneity in ventricular repolarization is a risk factor of sudden cardiac death, but its natural history is unclear. Here we examined whether insulin resistance is associated with longitudinal change in ventricular repolarization heterogeneity in apparently healthy subjects.

Methods: The study subjects were participants in health checkups in cohort 1 and cohort 2, which were followed up for 6 years and 5 years, respectively. Read More

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http://dx.doi.org/10.1007/s40119-019-0140-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6828911PMC
July 2019
1 Read

Ethnic and Gender Disparities in the Uptake of Transcatheter Aortic Valve Replacement in the United States.

Cardiol Ther 2019 Jun 25:151-155. Epub 2019 Jun 25.

Department of Cardiovascular Medicine, University of Kentucky, Lexington, KY, USA.

Introduction: Little is known about ethnic and gender disparities for transcatheter aortic valve replacement (TAVR) procedures in the United States.

Methods: We queried the Nationwide Inpatient Sample (NIS) database (2011-2014) to identify patients who underwent TAVR. We described the temporal trends in the uptake of TAVR procedures among various ethnicities and genders. Read More

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http://dx.doi.org/10.1007/s40119-019-0138-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6828867PMC
June 2019
3 Reads