302,492 results match your criteria Cardiology Review [Journal]


The appropriateness of coronary investigation in myocardial injury and type 2 myocardial infarction (ACT-2): A randomized trial design.

Am Heart J 2018 Oct 25;208:11-20. Epub 2018 Oct 25.

Department of Cardiology, Flinders Medical Centre, Adelaide, Australia; College of Medicine and Public Health, Flinders University of South Australia, Adelaide, Australia. Electronic address:

Background: Elevated troponin level findings among patients presenting with suspected acute coronary syndrome (ACS) or another intercurrent illness undeniably identifies patients at increased risk of mortality. Whilst enhancing our capacity to discriminate risk, the use of high-sensitivity troponin assays frequently identifies patients with myocardial injury (i.e. Read More

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October 2018
2 Reads

Systemic thrombolysis in haemodynamically unstable pulmonary embolism: The earlier the better?

Thromb Res 2018 Nov 29;173:117-123. Epub 2018 Nov 29.

Department of Cardiology, Santa Maria della Misericordia Hospital, Rovigo, Italy. Electronic address:

Introduction: The temporal window for the administration of systemic thrombolysis (ST) in acute pulmonary embolism (PE) has not yet been clarified. We assessed the relationship between short-term cardiovascular (CV) mortality and time of ST administration.

Material And Methods: Among 394 consecutive patients admitted between January 2010 and June 2017 with a confirmed PE, we retrospectively review the clinical and instrumental data of those labelled as high-risk PE (n = 76, 41 males, mean aged 64. Read More

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November 2018
4 Reads

Mechanistic role of the CREB-regulated transcription coactivator 1 in cardiac hypertrophy.

J Mol Cell Cardiol 2018 Dec 3. Epub 2018 Dec 3.

Department of Clinical Pharmacology and Toxicology, Cardiovascular Research Center, University Medical Center Hamburg-Eppendorf, Martinistr. 52, 20246 Hamburg, Germany; DZHK (German Center for Cardiovascular Research), Partner Site Hamburg, Kiel, Lübeck, Germany; Institute of Pharmacy, University of Hamburg, Bundesstr. 45, 20146 Hamburg, Germany. Electronic address:

The sympathetic nervous system is the main stimulator of cardiac function. While acute activation of the β-adrenoceptors exerts positive inotropic and lusitropic effects by increasing cAMP and Ca, chronically enhanced sympathetic tone with changed β-adrenergic signaling leads to alterations of gene expression and remodeling. The CREB-regulated transcription coactivator 1 (CRTC1) is activated by cAMP and Ca. Read More

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December 2018
1 Read

Accuracy of Calcium Scoring calculated from contrast-enhanced Coronary Computed Tomography Angiography using a dual-layer spectral CT: A comparison of Calcium Scoring from real and virtual non-contrast data.

PLoS One 2018 6;13(12):e0208588. Epub 2018 Dec 6.

Department of Diagnostic and Interventional Radiology, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.

Purpose: Modern non-invasive evaluation of Coronary Artery Disease (CAD) requires non-contrast low dose Computed Tomography (CT) imaging for determination of Calcium Scoring (CACS) and contrast-enhanced imaging for evaluation of vascular stenosis. Several methods for calculation of CACS from contrast-enhanced images have been proposed before. The main principle for that is generation of virtual non-contrast images by iodine subtraction from a contrast-enhanced spectral CT dataset. Read More

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December 2018
1 Read

Baroreflex function, haemodynamic responses to an orthostatic challenge, and falls in haemodialysis patients.

PLoS One 2018 6;13(12):e0208127. Epub 2018 Dec 6.

Queen Margaret University, Centre of Health, Activity and Rehabilitation Research, Edinburgh, United Kingdom.

Background: Stage 5 chronic kidney disease patients on haemodialysis (HD) often present with dizziness and pre-syncopal events as a result of the combined effect of HD therapy and cardiovascular disease. The dysregulation of blood pressure (BP) during orthostasis may be implicated in the aetiology of falls in these patients. Therefore, we explored the relationship between baroreflex function, the haemodynamic responses to a passive orthostatic challenge, and falls in HD patients. Read More

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December 2018

Platelet to lymphocyte ratio predicts all-cause mortality in patients with carotid arterial disease.

Rom J Intern Med 2018 Dec 1. Epub 2018 Dec 1.

TOBB Economy and Technology University, Cardiology Department, Ankara, Turkey.

Background: Platelet to lymphocyte ratio (PLR) has been demonstrated as an risk and prognostic marker in many of cardiovascular diseases. Relationship between PLR and severity of carotid stenosis has been shown. The aim of our study was to investigate the relationship between PLR and all cause mortality in patients with carotid arterial disease. Read More

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December 2018

Insight into the perioperative management of direct oral anticoagulants: concerns and considerations.

Expert Opin Pharmacother 2018 Dec 6:1-8. Epub 2018 Dec 6.

d Division of Cardiology, Department of Medicine and Therapeutics , The Chinese University of Hong Kong, Prince of Wales Hospital , Hong Kong , China.

Introduction: Direct oral anticoagulants (DOACs) have gained momentum in recent years in patients requiring anticoagulation for the prevention and management of venous thromboembolism and thromboembolic events caused by atrial fibrillation. The use of these agents involves potential bleeding complications, particularly during invasive procedures. With increasing use of DOACs, adequate knowledge regarding the perioperative management of patients on DOACs has become indispensable. Read More

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December 2018

Choosing an ideal pharmacotherapeutic strategy for dyslipidemia in children.

Expert Opin Pharmacother 2018 Dec 6:1-4. Epub 2018 Dec 6.

a Biomedical Department of Internal Medicine and Medical Specialties , University of Palermo , Palermo , Italy.

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December 2018
1 Read

Reproducibility of measuring QRS duration and implications for optimization of interventricular pacing delay in cardiac resynchronization therapy.

Ann Noninvasive Electrocardiol 2018 Dec 6:e12621. Epub 2018 Dec 6.

Department of Cardiology, Aarhus University Hospital, Aarhus N, Denmark.

Background: QRS narrowing after CRT is a predictor of patient outcome. Further narrowing can be obtained by interventricular pacing delay (VVd) optimization, raising interest to inter and intraobserver variation in manual measurements of QRS duration.

Methods: (a) Variation in intrinsic rhythm QRS duration in CRT patients with LBBB: In 40 intrinsic 12-lead ECGs, six observers measured QRS duration defined as widest QRS in any lead. Read More

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December 2018

Gallic Acid Suppresses Cardiac Hypertrophic Remodeling and Heart Failure.

Mol Nutr Food Res 2018 Dec 6:e1800807. Epub 2018 Dec 6.

Dr. X. Yan, Y.-L. Zhang, L. Zhang, L.-X. Zou, C. Chen, Prof. Y. Liu, Prof. Y.-L. Xia, Prof. H.-H. Li, Department of Nutrition and Food Hygiene, School of Public Health, Dalian Medical University, Dalian, 116044, China.

Scope: Gallic acid (GA) is a dietary phenolic acid found in tea, red wine, and some plants. It exhibits antioxidative and anti-inflammatory activities. Recent studies have revealed that GA has beneficial effects against several cardiovascular diseases; however, whether GA attenuates pressure overload-induced cardiac hypertrophy and the underlying mechanism remain unclear. Read More

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December 2018
1 Read

Effect of high fat diet on NF-кB microRNA146a negative feedback loop in ovalbumin-sensitized rats.

Biofactors 2018 Dec 6. Epub 2018 Dec 6.

Lung Inflammatory Diseases Research Center, Department of Physiology, Ardabil University of Medical Sciences, Ardabil, Iran.

The present study aimed to investigate the role of microRNA-146a and its adapter proteins [interleukin-1 receptor-associated kinase 1 (IRAK1) and tumor necrosis factor (TNF) receptor-associated factor 6 (TRAF6)] in the pathogenesis of ovalbumin (OVA)-sensitized rats in association with the diet-induced obesity condition. Twenty male Wistar rats were divided into four groups: control with normal diet (ND), OVA-sensitized with normal diet (S + ND), high-fat diet (HFD), and OVA-sensitized with high-fat diet (S + HFD). All the animals were fed for 8 weeks with standard pelts or high-fat diet, and were then sensitized and challenged with OVA or saline for another 4 weeks. Read More

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December 2018
1 Read

Predictors associated with an increased prevalence of postimplantation syndrome after thoracic endovascular aortic repair for type B aortic dissection.

Eur J Cardiothorac Surg 2018 Dec 5. Epub 2018 Dec 5.

Department of Cardiology, Vascular Center, Guangdong Cardiovascular Institute, Guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.

Objectives: The aim of this study was to identify patients who are at high risk of developing postimplantation syndrome (PIS) after thoracic endovascular aortic repair (TEVAR) for type B aortic dissection.

Methods: This retrospective study included 646 patients who underwent TEVAR for type B aortic dissection between January 2010 and December 2015 at the Guangdong General Hospital. PIS was defined as fever (>38°C) and leucocytosis (>12 000 μl-1) without evidence of infection. Read More

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December 2018

Prospective, randomized trial of bioresorbable scaffolds vs. everolimus-eluting stents in patients undergoing coronary stenting for myocardial infarction: the Intracoronary Scaffold Assessment a Randomized evaluation of Absorb in Myocardial Infarction (ISAR-Absorb MI) trial.

Eur Heart J 2018 Dec 5. Epub 2018 Dec 5.

Department of Cardiovascular Diseases, Deutsches Herzzentrum München, Technische Universität München, Lazarettstrasse 36, Munich, Germany.

Aims: Bioresorbable scaffolds (BRS) provide short-term coronary artery scaffolding and drug delivery. Although prior trials showed a higher rate of device failure compared with conventional drug-eluting stents (DES), only a single trial investigated patients undergoing percutaneous coronary intervention (PCI) for acute myocardial infarction (MI). We aimed to compare outcomes with BRS vs. Read More

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December 2018

Pretest probability for patients with suspected obstructive coronary artery disease: re-evaluating Diamond-Forrester for the contemporary era and clinical implications: insights from the PROMISE trial.

Eur Heart J Cardiovasc Imaging 2018 Dec 5. Epub 2018 Dec 5.

Cardiac MR PET CT Program, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, 165 Cambridge Street, Suite 400, Boston, USA.

Aims: To update pretest probabilities (PTP) for obstructive coronary artery disease (CAD ≥ 50%) across age, sex, and clinical symptom strata, using coronary computed tomography angiography (CTA) in a large contemporary population of patients with stable chest pain referred to non-invasive testing.

Methods And Results: We included patients enrolled in the Prospective Multicenter Imaging Study for Evaluation of Chest Pain (PROMISE) trial and randomized to CTA. Exclusively level III-certified readers, blinded to demographic and clinical data, assessed the prevalence of CAD ≥ 50% in a central core lab. Read More

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December 2018

[The second multicenter observational registry on the management of acute ST-elevation myocardial infarction in the Veneto Region (VENERE 2)].

Authors:

G Ital Cardiol (Rome) 2018 Dec;19(12):714-720

Background: We sought to evaluate the epidemiology and the management of ST-elevation acute myocardial infarction (STEMI) in the Veneto Region (VENERE 2) in 2014, 10 years after a similar survey conducted in the early 2000s.

Methods: Between October 2014 and March 2015, all consecutive patients admitted to the Cardiology Divisions of the Veneto Region with STEMI were enrolled in an observational, prospective, multicenter register, called VENERE 2. The main diagnostic and therapeutic efficiency indicators were analyzed and compared with data from the previous VENERE study performed 10 years earlier. Read More

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December 2018

[Journey around the heart in the movies of the last century: from Charlie Chaplin to the present day].

Authors:
Andrea Pozzati

G Ital Cardiol (Rome) 2018 Dec;19(12):664-667

U.O.S. Cardiologia, Ospedale Dossetti di Bazzano (BO), AUSL di Bologna.

Imagine a journey through the cinema's history to recover the figure of the doctor in the last century. At the same time, we have found that the progress of medicine has conditioned the stories told on the big screen. Cardiology has achieved a leading role at the cinema when technological innovations have begun to emerge, from the '60s onwards. Read More

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December 2018

Effect of Postablation Statin Treatment on Arrhythmia Recurrence in Patients With Paroxysmal Atrial Fibrillation.

J Cardiovasc Pharmacol 2018 Dec;72(6):285-290

2nd Department of Cardiology, University of Athens Medical School, Attikon Hospital, Athens, Greece.

Background: Statins have been proposed as a means to prevent postablation atrial fibrillation (AF) recurrences, mainly on the basis of their pleiotropic effects. The objective of this subanalysis of a prospectively randomized controlled study population of patients undergoing radiofrequency ablation for paroxysmal AF was to test the hypothesis that statin treatment is associated with longer time to recurrence.

Methods And Results: This is a subanalysis over an extended follow-up period of a prospective randomized study (ClinicalTrials. Read More

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December 2018

Racial Disparities in the Cardiac Computed Tomography Assessment of Coronary Artery Disease: Does Gender Matter.

Cardiol Rev 2019 Jan/Feb;27(1):14-22

Department of Surgery, Westchester Medical Center, Valhalla, NY.

Coronary heart disease (CHD) represents a significant healthcare burden in terms of hospital resources, morbidity, and mortality. Primary prevention and early detection of risk factors for the development of CHD are pivotal to successful intervention programs and prognostication. Yet, there remains a paucity of evidence regarding differences in the assessment of these risk factors and the tools of assessment among different ethnicities. Read More

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December 2018
2 Reads

Gastrointestinal Bleeding During Continuous-Flow Left Ventricular Assist Device Support: State of the Field.

Cardiol Rev 2019 Jan/Feb;27(1):8-13

Division of Cardiology, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY 10467.

Continuous-flow left ventricular assist devices (CF-LVADs) are increasingly used for the management of advanced heart failure refractory to optimal medical therapy. Despite the encouraging outcomes with CF-LVADs, gastrointestinal bleeding (GIB) continues to be a rather concerning complication resulting in increased rates of readmission and increased morbidity. The exact pathophysiology of CF-LVAD-associated GIB remains poorly understood, and this lack of knowledge limits our ability to control this morbid complication. Read More

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December 2018

Evaluation of triage quality in the emergency department: a scoping review protocol.

JBI Database System Rev Implement Rep 2018 Dec 4. Epub 2018 Dec 4.

School of Nursing, University of São Paulo, São Paulo, Brazil.

Review Questions: The objective of this scoping review is to explore the existing literature on the evaluation of the quality of triage for patients of all ages and medical conditions in emergency departments (ED).The question for this review is: How is triage in ED evaluated? More specifically, we are interested in answering the following sub-questions. Read More

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December 2018

Left Atrial Appendage Occlusion in the Management of Stroke in Patients With Atrial Fibrillation.

Cardiol Rev 2018 Dec 4. Epub 2018 Dec 4.

Division of Cardiology, New York Medical College/Westchester Medical Center, Valhalla, NY.

Atrial fibrillation (AF) is associated with a substantially higher risk of thromboembolism, particularly stroke events, resulting in significant morbidity and mortality. Oral anticoagulation (OAC), while effective in reducing embolic events in AF patients, is associated with an increased bleeding risk. Thus, not all patients with AF are candidates for OAC and some are only candidates for OAC in the short term. Read More

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December 2018
1 Read

High-sensitivity troponin T is a prognostic marker of hemodynamic instability in patients undergoing valve surgery.

Biomark Med 2018 Dec 6. Epub 2018 Dec 6.

Department of Acquired Cardiac Defects, Institute of Cardiology, Warsaw, Poland.

Aim: The usefulness of high-sensitivity troponin T (hs-TnT) as a predictor of perioperative hemodynamic instability is currently unknown.

Methods: A prospective study was conducted on a group of 708 consecutive patients with significant valvular heart disease that underwent elective valve surgery. The primary end point was postoperative hemodynamic instability. Read More

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December 2018

The usefulness of selected biomarkers in patients with valve disease.

Biomark Med 2018 Dec 6. Epub 2018 Dec 6.

Department of Acquired Cardiac Defects, Institute of Cardiology,  Warsaw, Poland.

Aim: The aim of the study was to investigate the prognostic value of selected biomarkers in patients undergoing valve surgery.

Materials & Methods: A prospective study was conducted on a group of consecutive patients with hemodynamically significant valve defects that underwent elective valve repair or replacement surgery. The primary end point was any major adverse event including death within 30 days. Read More

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December 2018
2 Reads

Apixaban-Associated Spontaneous Splenic Rupture-A Case Report.

Ir Med J 2018 08 13;111(7):792. Epub 2018 Aug 13.

University Hospital Galway, Ireland

Introduction A 62-year-old lady presented to The Emergency Department (ED) with one-day history of dizziness, vomiting and feeling weak. ECG showed new onset Atrial Fibrillation. Four days ago, she was referred to the Cardiology team where she underwent PCI and was discharged on Apixaban and Plavix. Read More

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Idarucizumab for the reversal of dabigatran in patients undergoing heart transplantation.

Eur J Heart Fail 2018 Dec 6. Epub 2018 Dec 6.

Department of Cardiology, University Hospitals Leuven, Leuven, Belgium.

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December 2018

Effects of sacubitril/valsartan on neprilysin targets and the metabolism of natriuretic peptides in chronic heart failure: a mechanistic clinical study.

Eur J Heart Fail 2018 Dec 6. Epub 2018 Dec 6.

Inserm UMR-S 942, Lariboisière Hospital, Paris, France.

Aim: This study aimed at evaluating the effects of sacubitril/valsartan on neprilysin (NEP), and the metabolism of natriuretic peptides in heart failure (HF) and providing additional mechanistic information on the mode of action of the drug.

Methods And Results: We enrolled 73 chronic HF patients who were switched from angiotensin-converting enzyme inhibitor or angiotensin receptor blocker to sacubitril/valsartan. In addition to clinical and echocardiographic assessment, plasma biomarkers were measured at baseline, day 30 and day 90 after initiation of treatment. Read More

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December 2018

Prognostic value of multiple repeated biomarkers in pulmonary arterial hypertension associated with congenital heart disease.

Eur J Heart Fail 2018 Dec 6. Epub 2018 Dec 6.

Department of Clinical and Experimental Cardiology, Amsterdam Cardiovascular Sciences, Amsterdam UMC, University of Amsterdam, Heart Centre, Amsterdam, The Netherlands.

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December 2018

The QTc interval and risk of cardiac events in bulimia nervosa: A long-term follow-up study.

Int J Eat Disord 2018 Dec 6. Epub 2018 Dec 6.

Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark.

Objective: An association between bulimia nervosa (BN) and prolonged corrected QT interval (QTc) in the electrocardiogram has been suggested, but results of previous studies are conflicting, and the risk of cardiac events in patients with BN has yet to be investigated.

Method: We estimated mean QTc interval and relative risk of borderline (QTc >440 ms) and prolonged QTc (QTc >460 ms) between adult women with BN (N = 531) and healthy controls (N = 123). In follow-up analyses, we investigated the risk of a primary endpoint (syncope, ventricular tachycardia, and cardiac arrest) and all-cause mortality in patients with BN (N = 702) compared with a population-based cohort derived from the Danish Civil Register (N = 7,020). Read More

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December 2018
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A minimally-invasive hybrid approach for cardiac resynchronization of the systemic right ventricle.

Pacing Clin Electrophysiol 2018 Dec 6. Epub 2018 Dec 6.

University of California Los Angeles, Department of Cardiothoracic Surgery, UCLA Medical Center, Los Angeles, CA.

Background: Patients with systemic right ventricles (RV) often develop progressive heart failure and may benefit from cardiac resynchronization therapy (CRT), however the optimal strategy for CRT has not been defined.

Methods: A retrospective review of all patients with systemic RV failure undergoing a hybrid transcatheter-surgical approach was performed. Procedural technique and outcomes are reported. Read More

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December 2018

Development of an oral anticoagulant-use attitude scale, and assessment of its validity and reliability.

Saudi Med J 2018 Dec;39(12):1242-1248

Department of Fundamentals, Sakarya University, Sakarya, Turkey. E-mail.

Objectives: To develop a reliable scale that can measure the attitudes of individuals using oral anticoagulant drugs (OACs). Methods: This methodological study was conducted with 296 followed-up individuals using OACs for at least 6 months and visiting the cardiology and neurology clinics of a hospital in Turkey during 2017. A 20-item pool was used to construct the scale and all items were found suitable after content validity analysis and preliminary testing. Read More

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December 2018

[What's new in the 2018 ESC/EACTS guidelines on myocardial revascularization?]

G Ital Cardiol (Rome) 2018 Nov;19(11):5-9

Klinik für Kardiologie und Angiologie II, Universitäts-Herzzentrum Freiburg, Bad Krozingen, Germania.

A revised version of the European Society of Cardiology (ESC) and European Association for Cardio-Thoracic Surgery (EACTS) guidelines on myocardial revascularization has recently been published. These guidelines represent the third time that the ESC and EACTS have brought together cardiologists and cardiac surgeons in a joint Task Force to review the available evidence, with the mission of drafting balanced, patient-oriented, clinical practice guidelines on myocardial revascularization. During the last 4 years, a large body of evidence has become available and brought substantial changes to the guidelines. Read More

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November 2018

Circular RNA expression profiles of persistent atrial fibrillation in patients with rheumatic heart disease.

Anatol J Cardiol 2018 Dec 6. Epub 2018 Dec 6.

Department of Cardiology, Xijing Hospital, Air Force Military Medical University (Fourth Military Medical University); Xi'an-China.

Objective: To investigate the expression profile of circular RNAs (circRNAs) and proposed circRNA-microRNA (miRNA) regulatory network in atrial fibrillation (AF).

Methods: Atrial tissues from patients with persistent AF with rheumatic heart disease and non-AF myocardium with normal hearts were collected for circRNA differential expression analyses by high-throughput sequencing. The Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses were performed to predict the potential functions of the differentially expressed genes and AF-related pathways. Read More

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December 2018

A rare complication of balloon pulmonary angioplasty: Aortopulmonary window and its treatment.

Anatol J Cardiol 2018 Dec 6. Epub 2018 Dec 6.

Department of Pediatric Cardiology, Faculty of Medicine, Başkent University; Ankara-Turkey.

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December 2018

Non-ergot dopamine agonists and heart failure.

Anatol J Cardiol 2018 Dec 6. Epub 2018 Dec 6.

Department of Cardiology, Faculty of Medicine, Hacettepe University; Ankara-Turkey.

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December 2018

Heart rate in heart failure with mid-range ejection fraction.

Anatol J Cardiol 2018 Dec 6. Epub 2018 Dec 6.

Department of Cardiology, Faculty of Medicine, Cumhuriyet University; Sivas-Turkey.

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December 2018
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The real-life data of hospitalized patients with heart failure: On behalf of the Journey HF-TR study investigators.

Anatol J Cardiol 2018 Dec 6. Epub 2018 Dec 6.

Department of Cardiology, Faculty of Medicine, İstanbul University, Institute of Cardiology; İstanbul-Turkey.

Objective: Acute heart failure (AHF) is a life-threatening clinical syndrome characterized by rapid onset of heart failure (HF) symptoms and signs and requires urgent therapy. The aim of the present study was to evaluate the overall clinical characteristics, management, and in-hospital outcomes of hospitalized patients with AHF in a large sample of Turkish population.

Methods: The Journey HF-TR study is a cross-sectional, multicenter, non-invasive and observational trial. Read More

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December 2018

Type I Brugada pattern associated with diabetic ketoacidosis in a patient with type II diabetes mellitus.

Anatol J Cardiol 2018 Dec 6. Epub 2018 Dec 6.

Department of Cardiology, Koşuyolu Kartal Training and Research Hospital; İstanbul-Turkey.

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December 2018

The impact of heart rate on patients diagnosed with heart failure with mid-range ejection fraction.

Anatol J Cardiol 2018 Dec 6. Epub 2018 Dec 6.

Department of Cardiology, The First Affiliated Hospital, China Medical University; Shenyang-China.

Objective: The relationship between prognosis and heart rate remains unclear among patients diagnosed with heart failure with mid-range ejection fraction (HFmrEF). The aim of the present study was to assess the effect of heart rate in this group of patients.

Methods: Of the 197 patients diagnosed with HFmrEF, 92 had a heart rate <70 beats/min (bpm), and 105 had a heart rate ≥70 bpm. Read More

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December 2018

A Case of a Cardiac Cephalgia.

Can J Neurol Sci 2018 Dec 6:1-3. Epub 2018 Dec 6.

Department of Clinical Neurosciences Cumming School of MedicineUniversity of Calgary,Calgary Alberta,Canada.

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December 2018

Extensively thrombosed ectatic circumflex coronary artery fistula presenting as acute coronary syndrome.

Curr Cardiol Rev 2018 Dec 6. Epub 2018 Dec 6.

Department of Cardiology, University Heart Center, University Hospital Zurich. Switzerland.

Background: Coronary artery fistula (CAF) is an abnormal communication between the termination of a coronary artery or its branches and a cardiac chamber, a great vessel or other vascular structure. Symptomatic patients with large CAF should undergo surgical or percutanous closure of the fistula at the drainage site while still the debate on closing asymptomatic CAF and re-openening symptomatic occluded CAF is ongoing.

Case Summary: We are reporting a 30-year-old male patient with no previous medical history presented as non-ST segment elevation myocardial Infarction. Read More

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December 2018

Safety of Sports for Young Patients With Implantable Cardioverter-Defibrillators.

Circ Arrhythm Electrophysiol 2018 Nov;11(11):e006305

Yale University School of Medicine, New Haven, CT (J.D., C.B., L.S., F.L., R.J.L.).

Background: Despite safety concerns, many young patients with implantable cardioverter-defibrillators (ICDs) participate in sports. We undertook a prospective, multinational registry to determine the incidence of serious adverse events because of sports participation. The primary end points were death or resuscitated arrest during sports or injury during sports because of arrhythmia or shock. Read More

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November 2018

Novel Insights in the Activation Patterns at the Pulmonary Vein Area.

Circ Arrhythm Electrophysiol 2018 Nov;11(11):e006720

Department of Cardiology, Erasmus Medical Center, Rotterdam, The Netherlands (E.M.J.P.M., L.J.M.E.v.d.D., E.A.H.L., C.P.T., P.K., N.M.S.d.G.).

Background: Extensiveness of conduction delay and block at the pulmonary vein area (PVA) was quantified in a previous study. We hypothesized that the combination of lines of conduction block with multiple concomitantly entering sinus rhythm wavefronts at the PVA may result in increased arrhythmogenicity and susceptibility to atrial fibrillation (AF).

Methods: Intraoperative high-density epicardial mapping of PVA (N≈450 sites, interelectrode distances: 2 mm) was performed during sinus rhythm in 327 patients (241 male [74%], 67±10 [21-84] years) with and without preoperative AF. Read More

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November 2018

Development of exercise-related values in heart failure patients supported with a left ventricular assist device.

Int J Artif Organs 2018 Dec 6:391398818815492. Epub 2018 Dec 6.

1 Schüchtermann-Klinik Bad Rothenfelde, Bad Rothenfelde, Germany.

Following implantation of a left ventricular assist device, the build-up and long-term maintenance of adequate exercise capacity and functional performance become crucial. The aim of this study was to observe the development of exercise-related values at different times, as well as to detect possible influencing factors. We performed a prospective single-centre study: 10 patients (63 years, 100% male, body mass index = 27. Read More

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December 2018

PCSK9 inhibitors and diabetes: translational biology to clinical practice.

Diabetes Obes Metab 2018 Dec 5. Epub 2018 Dec 5.

Division of Cardiology, UT Health San Antonio, San Antonio, TX.

Improving patient care incorporates well done translational science with excellent clinical trials. The development of new medications beyond statins to reduce low-density lipoprotein (LDL) in patients who are at high risk for cardiovascular (CV) events has ushered in new concerns by physicians from recent clinical trials. This article is protected by copyright. Read More

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December 2018

Perinatal changes in fetal cardiac geometry and function in gestational diabetic pregnancies at term.

Ultrasound Obstet Gynecol 2018 Dec 6. Epub 2018 Dec 6.

Molecular & Clinical Sciences Research Institute, St George's University of London.

Objective: To evaluate the effect of gestational diabetes mellitus (GDM) on fetal and neonatal cardiac geometry and function around the time of birth.

Methods: A prospective study of 75 pregnant women delivering at term, comprising of 54 normal pregnancies and 21 with a diagnosis GDM. Fetal and neonatal conventional cardiac indices, spectral tissue Doppler and 2D speckle tracking imaging were performed a few days before and within hours of birth. Read More

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December 2018
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A novel model for predicting non-responsiveness to intravenous immunoglobulins in Kawasaki disease: The Singapore experience.

J Paediatr Child Health 2018 Dec 5. Epub 2018 Dec 5.

Division of Paediatric Cardiology, Khoo Teck Puat-National University Children's Medical Institute, National University Health System, Singapore.

Aim: We aimed to assess the utility of four published risk-scoring methods in predicting intravenous immunoglobulins (IVIG) non-responsiveness in Kawasaki disease (KD) patients from Singapore and develop a new predictive model.

Methods: We reviewed the medical records of 215 KD children. The performance of existing scoring methods in identifying non-responsive cases based on sensitivities (SN) and specificities (SP) was evaluated in 122 Singaporean Chinese. Read More

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December 2018
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Left ventricular mass regression after aortic valve replacement: Sex differences or effect of different methods of indexation?

Echocardiography 2018 Dec 5. Epub 2018 Dec 5.

Cardiac Surgery, Careggi University Hospital, Florence, Italy.

Background: The influence of sex on regression of left ventricular (LV) hypertrophy (LVH) after aortic valve replacement (AVR) for aortic stenosis (AS) remains elusive. The lack of consensus on how to correct LV mass (LVM) for body size, and different normalcy values, contribute to inconclusive results.

Methods: In 164 consecutive patients (mean age 80 ± 4 years, 59% females) with AS, we analyzed LVM (Devereux formula) before and 1 year after AVR (St. Read More

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December 2018