30,663 results match your criteria Cardiology[Journal]


Risk of Cardiovascular Mortality Associated With Serum Sodium and Chloride in the General Population.

Can J Cardiol 2018 Mar 29. Epub 2018 Mar 29.

Department of Cardiology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China; Key Laboratory on Assisted Circulation, Ministry of Health, Guangzhou, China. Electronic address:

Background: The prognostic value of serum chloride among patients with heart failure was demonstrated by previous studies. However, the association of serum chloride and risk of cardiovascular mortality among the general population remains unclear.

Methods: We included 16,483 participants in National Health and Nutrition Examination Survey III. Read More

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Sodium, Chloride, and Cardiovascular Mortality-Open Access Data Is Worth Its Salt.

Authors:
James M Brophy

Can J Cardiol 2018 Apr 11. Epub 2018 Apr 11.

McGill University Health Center, Centre for Health Outcomes Research (CORE), Montreal, Québec, Canada. Electronic address:

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Comparison of Cardiac Magnetic Resonance Imaging and Echocardiography in Assessment of Left Ventricular Hypertrophy in Fabry Disease.

Can J Cardiol 2018 Mar 29. Epub 2018 Mar 29.

Department of Medical Genetics and Pediatrics, University of Calgary Cumming School of Medicine, Alberta Children's Hospital Research Institute, Calgary, Alberta, Canada. Electronic address:

Background: Cardiac hypertrophy in Fabry disease can be assessed using the left ventricular mass index (LVMI) with either echocardiography (LVMI-ECHO) or magnetic resonance imaging (LVMI-CMR).

Methods: A retrospective case series of patients with Fabry disease in Alberta involved a cross-sectional analysis of 32 patients and a longitudinal analysis of 14 of these patients with at least 4 serial CMR measurements.

Results: The cross-sectional analysis showed the mean LVMI-ECHO was 97. Read More

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A concise discussion of the regulatory role of cGMP kinase I in cardiac physiology and pathology.

Authors:
Franz Hofmann

Basic Res Cardiol 2018 Jun 22;113(4):31. Epub 2018 Jun 22.

Institut für Pharmakologie und Toxikologie, TU München, Biedersteiner Str. 29, 80802, Munich, Germany.

The underlying cause of cardiac hypertrophy, fibrosis, and heart failure has been investigated in great detail using different mouse models. These studies indicated that cGMP and cGMP-dependent protein kinase type I (cGKI) may ameliorate these negative phenotypes in the adult heart. Recently, evidence has been published that cardiac mitochondrial BKCa channels are a target for cGKI and that activation of mitoBKCa channels may cause some of the positive effects of conditioning in ischemia/reperfusion injury. Read More

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Inflammatory and atherogenic effects of oxidized phospholipids.

Authors:
Gregory B Lim

Nat Rev Cardiol 2018 Jun 22. Epub 2018 Jun 22.

Nature Reviews Cardiology, .

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Chronotherapy for atherosclerosis.

Nat Rev Cardiol 2018 Jun 21. Epub 2018 Jun 21.

Nature Reviews Cardiology, .

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High-Sensitivity Troponin and Heart Failure With Preserved Ejection Fraction-Balancing P Values With Prior Knowledge and Common Sense-Reply.

JAMA Cardiol 2018 Jun 20. Epub 2018 Jun 20.

Cardiology Division, Department of Medicine, Massachusetts General Hospital, Boston.

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71-Year-Old Man With Recurrent Dyspnea Following Transcatheter Aortic Valve Replacement.

JAMA Cardiol 2018 Jun 20. Epub 2018 Jun 20.

Department of Medicine, University of California-San Francisco, San Francisco.

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JAMA Cardiology.

Authors:

JAMA Cardiol 2018 Jun;3(6):451

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Error in Figure Data.

Authors:

JAMA Cardiol 2018 Jun;3(6):505

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Association of LPA Variants With Risk of Coronary Disease and the Implications for Lipoprotein(a)-Lowering Therapies: A Mendelian Randomization Analysis.

JAMA Cardiol 2018 Jun 20. Epub 2018 Jun 20.

MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom.

Importance: Human genetic studies have indicated that plasma lipoprotein(a) (Lp[a]) is causally associated with the risk of coronary heart disease (CHD), but randomized trials of several therapies that reduce Lp(a) levels by 25% to 35% have not provided any evidence that lowering Lp(a) level reduces CHD risk.

Objective: To estimate the magnitude of the change in plasma Lp(a) levels needed to have the same evidence of an association with CHD risk as a 38.67-mg/dL (ie, 1-mmol/L) change in low-density lipoprotein cholesterol (LDL-C) level, a change that has been shown to produce a clinically meaningful reduction in the risk of CHD. Read More

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June 2018
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High-Sensitivity Troponin and Heart Failure With Preserved Ejection Fraction-Balancing P Values With Prior Knowledge and Common Sense.

Authors:
John W McEvoy

JAMA Cardiol 2018 Jun 20. Epub 2018 Jun 20.

Johns Hopkins Ciccarone Center for the Prevention of Heart Disease, Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland.

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Changes in the Association of Rising Infective Endocarditis With Mortality in People Who Inject Drugs.

JAMA Cardiol 2018 Jun 20. Epub 2018 Jun 20.

Harrington Heart and Vascular Institute, University Hospitals Cleveland Medical Center, Cleveland, Ohio.

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Association of Multifocal Fibromuscular Dysplasia in Elderly Patients With a More Benign Clinical Phenotype: Data From the US Registry for Fibromuscular Dysplasia.

JAMA Cardiol 2018 Jun 20. Epub 2018 Jun 20.

Vascular Medicine Section, Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland, Ohio.

Importance: Fibromuscular dysplasia (FMD) is a nonatherosclerotic arterial disease that predominately affects women and is most commonly diagnosed in middle age. The natural history of FMD among patients diagnosed at an older age is not well understood.

Objective: To examine the differences in clinical presentation, arterial bed involvement, vascular events, and need for vascular procedures between younger and older patients with FMD. Read More

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June 2018
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Defining the New Normal in Cardiovascular Risk Factors.

JAMA Cardiol 2018 Jun 20. Epub 2018 Jun 20.

Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois.

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Reply to 'Salt intake, cardiovascular disease, and physiology'.

Nat Rev Cardiol 2018 Jun 19. Epub 2018 Jun 19.

Wolfson Institute of Preventive Medicine, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.

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Sodium intake, cardiovascular disease, and physiology.

Authors:
Simon N Thornton

Nat Rev Cardiol 2018 Jun 19. Epub 2018 Jun 19.

Université de Lorraine, Inserm, DCAC, Nancy, France.

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Association of Thromboembolic Risk Score with Left Atrial Thrombus and Spontaneous Echocardiographic Contrast in Non-Anticoagulated Nonvalvular Atrial Fibrillation Patients.

Cardiology 2018 Jun 19;140(2):87-95. Epub 2018 Jun 19.

School of Public Health, Sun Yat-sen University, Guangzhou, China.

Objectives: The aim of the study was to examine the association of CHADS2/CHA2DS2-VASc scores with left atrial thrombus (LAT) and spontaneous echocardiographic contrast (SEC) in non-anticoagulated nonvalvular atrial fibrillation (NVAF) spontaneous patients, and to develop a new scoring system for LAT/SEC prediction.

Methods: Consecutive non-anticoagulated NVAF patients with or without LAT/SEC by transesophageal echocardiography were identified in the Guangdong General Hospital.

Results: Among 2,173 patients, the prevalence of LAT/SEC was 4. Read More

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Apolipoprotein A-I proteolysis in aortic valve stenosis: role of cathepsin S.

Basic Res Cardiol 2018 Jun 18;113(4):30. Epub 2018 Jun 18.

Montreal Heart Institute, Université de Montréal, 5000 Belanger Street, Montreal, H1T 1C8, Canada.

Aortic valve stenosis (AVS) is the most common valvular heart disease in the Western world. Therapy based on apolipoprotein A-I (apoA-I), the major protein component of high-density lipoproteins, results in AVS regression in experimental models. Nevertheless, apoA-I degradation by proteases might lead to suboptimal efficacy of such therapy. Read More

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Metabolic remodelling in heart failure.

Nat Rev Cardiol 2018 Jun 18. Epub 2018 Jun 18.

Comprehensive Heart Failure Center (CHFC), University Clinic Würzburg, Würzburg, Germany.

The heart consumes large amounts of energy in the form of ATP that is continuously replenished by oxidative phosphorylation in mitochondria and, to a lesser extent, by glycolysis. To adapt the ATP supply efficiently to the constantly varying demand of cardiac myocytes, a complex network of enzymatic and signalling pathways controls the metabolic flux of substrates towards their oxidation in mitochondria. In patients with heart failure, derangements of substrate utilization and intermediate metabolism, an energetic deficit, and oxidative stress are thought to underlie contractile dysfunction and the progression of the disease. Read More

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Physiological and unappreciated roles of CaMKII in the heart.

Basic Res Cardiol 2018 Jun 15;113(4):29. Epub 2018 Jun 15.

Department for Molecular Cardiology and Epigenetics, University Hospital Heidelberg, Im Neuenheimer Feld 669, 69120, Heidelberg, Germany.

In the cardiomyocyte, CaMKII has been identified as a nodal influencer of excitation-contraction and also excitation-transcription coupling. Its activity can be regulated in response to changes in intracellular calcium content as well as after several post-translational modifications. Some of the effects mediated by CaMKII may be considered adaptive, while effects of sustained CaMKII activity may turn into the opposite and are detrimental to cardiac integrity and function. Read More

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: Type 2 Diabetes and Readmission for Heart Failure.

Authors:
Merlin C Thomas

Clin Med Insights Cardiol 2018 5;12:1179546818779588. Epub 2018 Jun 5.

Department of Diabetes, Central Clinical School, Monash University, Melbourne, VIC, Australia.

Heart failure is a leading cause for hospitalisation and for readmission, especially in patients over the age of 65. Diabetes is an increasingly common companion to heart failure. The presence of diabetes and its associated comorbidity increases the risk of adverse outcomes and premature mortality in patients with heart failure. Read More

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Effect of Xanthine Oxidase Inhibition on Arterial Stiffness in Patients With Chronic Heart Failure.

Clin Med Insights Cardiol 2018 5;12:1179546818779584. Epub 2018 Jun 5.

Institute of Cardiovascular & Medical Sciences, University of Glasgow, Glasgow, UK.

Background: The xanthine oxidase inhibitor allopurinol improves endothelial function in different populations, including patients with chronic heart failure (CHF). Its effect on arterial stiffness parameters is less clear. We investigated the effect of short-term low-dose allopurinol therapy on arterial stiffness in Saudi patients with stable mild-moderate CHF. Read More

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Comparison of Verapamil versus Heparin as Adjunctive Treatment for Transradial Coronary Procedures: The VERMUT Study.

Cardiology 2018 Jun 13;140(2):74-82. Epub 2018 Jun 13.

Cardiology Unit, Azienda Ospedaliera Universitaria di Ferrara, Cona, Italy.

Objective: We sought to demonstrate that the combination of a local vasodilator (verapamil), modern materials, patent hemostasis, and intravenous anticoagulant only in the case of percutaneous coronary intervention, as compared to default heparin administration after sheath insertion, may optimize a combined endpoint, including radial artery oc-clusion (RAO), radial artery spasm (RAS), and access site complication.

Methods: This is a prospective, single-center, double-blind randomized trial. Overall, 418 patients undergoing a transradial approach (TRA) for coronary procedures were randomized 1: 1 to receive intraradial verapamil (5 mg) or heparin (5,000 IU) after a 6-Fr sheath insertion. Read More

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June 2018
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Hybrid Coronary Revascularization and the Hybrid Cardiovascular Operating Room.

Cardiology 2018 Jun 13;140(2):83-86. Epub 2018 Jun 13.

Division of Cardiovascular Medicine, Department of Medicine, The Ohio State University, Columbus, Ohio, USA.

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Subtotal Occlusion of Left Anterior Coronary Artery in a Professional Athlete.

Cardiology 2018 Jun 13;140(2):71-73. Epub 2018 Jun 13.

1st Department of Pediatrics, Athens University Medical School, Children's Hospital "Aghia Sophia", Athens, Greece.

Screening for cardiovascular disease in athletes is crucial to avoid life-threatening complications. Here, we present the case of a fairly asymptomatic young professional soccer player with several cardiovascular risk factors, who proved to have significant coronary artery disease on coronary computed tomography which was ordered based on clinical suspicion and his family history. Informed consent for publication was obtained from the patient. Read More

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Association of Patient Perceptions of Cardiovascular Risk and Beliefs on Statin Drugs With Racial Differences in Statin Use: Insights From the Patient and Provider Assessment of Lipid Management Registry.

JAMA Cardiol 2018 Jun 13. Epub 2018 Jun 13.

Duke Clinical Research Institute, Duke University School of Medicine, Durham, North Carolina.

Importance: African American individuals face higher atherosclerotic cardiovascular disease risk than white individuals; reasons for these differences, including potential differences in patient beliefs regarding preventive care, remain unknown.

Objective: To evaluate differences in statin use between white and African American patients and identify the potential causes for any observed differences.

Design, Setting, And Participants: Using the 2015 Patient and Provider Assessment of Lipid Management (PALM) Registry data, we compared statin use and dosing between African American and white outpatient adults who were potentially eligible for primary or secondary prevention statins. Read More

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June 2018
2 Reads

Comparison of Low-density Lipoprotein Cholesterol Assessment by Martin/Hopkins Estimation, Friedewald Estimation, and Preparative Ultracentrifugation: Insights From the FOURIER Trial.

JAMA Cardiol 2018 Jun 13. Epub 2018 Jun 13.

Thrombolysis in Myocardial Infarction (TIMI) Study Group, Division of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, Massachusetts.

Importance: Recent studies have shown that Friedewald underestimates low-density lipoprotein cholesterol (LDL-C) at lower levels, which could result in undertreatment of high-risk patients. A novel method (Martin/Hopkins) using a patient-specific conversion factor provides more accurate LDL-C levels. However, this method has not been tested in proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitor-treated patients. Read More

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June 2018
3 Reads

Addressing Cardiovascular Disease Disparities-Are We Getting Closer to the Truth?

Authors:
Clyde W Yancy

JAMA Cardiol 2018 Jun 13. Epub 2018 Jun 13.

Feinberg School of Medicine, Northwestern University, Chicago, Illinois.

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Measuring Low-Density Lipoprotein Cholesterol: When Is More Accurate Better?

Authors:
Neil J Stone

JAMA Cardiol 2018 Jun 13. Epub 2018 Jun 13.

Feinberg School of Medicine, Northwestern University, Chicago, Illinois.

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Does Resting or Exercise Electrocardiography Assist Clinicians in Preventing Cardiovascular Events in Asymptomatic Adults?

Authors:
Joseph S Alpert

JAMA Cardiol 2018 Jun 12. Epub 2018 Jun 12.

University of Arizona College of Medicine, Tucson.

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[Experience of hospital initiation of sacubitril/valsartan in a female patient after acute decompensated heart failure].

Kardiologiia 2018 SMay(S5):60-64

Federal State Autonomous Educational Institution of Higher Education, "Peoples' Friendship University of Russia".

The article discusses management of a female patient with chronic heart failure with reduced left ventricular ejection fraction after an episode of acute decompensation. Replacing an angiotensin-converting enzyme inhibitor with a representative of a new angiotensin receptor-neprilysin inhibitor class, sacubitril/valsartan, in the combination therapy allowed fast achievement and maintenance of the compensation state. The treatment was well tolerated and was not associated with clinically significant adverse effects. Read More

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June 2018
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[The quality of treatment of patients with atrial fibrillation, depending on the index of polymorbidity, preceded hospitalization for acute coronary syndrome].

Kardiologiia 2018 SMay(S5):54-59

Federal State Budgetary Educational Institution of Higher Education, "Nizhny Novgorod State Medical Academy" of the Ministry of Health of the Russian Federation.

The aim of this work was a retrospective assessment of the quality of treatment, depending on the severity of polymorbidity (PM) in patients with atrial fibrillation (AF) before admission to acute coronary syndrome (ACS).

Materials And Methods: Retrospectively, 105 patients were included in the analysis (54 men (51,4 %), mean age 65,94±9,34 years) who had AF before hospitalization for ACS. The index of polymorbidity (IPM) was assessed by ME Charlson et al. Read More

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[Evaluation of long-term adverse cardiovascular events risk after elective percutaneous coronary intervention].

Kardiologiia 2018 SMay(S5):45-53

Federal State Budgetary Science Institution "Tomsk Research Institute of Cardiology of the Siberian Branch of the Russian Academy of Science".

Objective: The aim of our study was to analyze long-term outcomes, to identify their predictors and to develop a model for determining the risk of long-term adverse сardiovascular events after elective percutaneous coronary interventions (PCI).

Materials And Methods: A retrospective study included 151 patients 6 years after the elective PCI. Outcomes were assessed by analyzing medical records and telephone interviews. Read More

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June 2018
3 Reads

[Features of red blood indexes in elderly patients with ischemic heart disease and pathology of heart valves before and after surgical correction].

Kardiologiia 2018 SMay(S5):37-44

South Ural State Medical University.

Due to current options of cardiac surgery, operations on the heart of elderly patients have become routine in specialized cardiosurgical centers. The issue of pre- and postoperative anemia of different nature is essential in surgical correction of heart valves and coronary bypass.

Aim: To study indexes of red blood in elderly patients with ischemic heart disease (IHD) and pathology of heart valves before and after surgical correction, including the relationship with position and type of the prosthesis. Read More

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[Calculator "Available prognosis": Method of evaluation for predicting survival of patients with chronic heart failure and reduced left ventricular ejection fraction].

Kardiologiia 2018 SMay(S5):30-36

Federal State Budgetary Institution "Federal Almazov North-West Medical Research Center" of the Ministry of Health of the Russian Federation.

Background: A method for predicting one-year survival of patients with heart failure and reduced ejection fraction (HFrEF) is required to choose a management tactics and determine indications for high-tech care at the outpatient stage.

Aim: To develop a method for proper prediction of survival of patients with HFrEF in outpatient clinics.

Materials And Methods: This was a prospective study of 212 patients with functional class II-IV CHF of non-valvular origin and LV EF (Simpson) ≤35 % aged 18-70, including 176 (83 %) men and 36 (17 %) women who had given an informed consent to participate in the study. Read More

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June 2018
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[Prevention of periprocedural kidney ingury by loading doses of statins in elective percutaneous сoronary interventions].

Kardiologiia 2018 SMay(S5):20-29

Tomsk National Research Medical Center of the Russian Academy of Science, Goldberg Research Institute of Pharmacology and Regenerative Medicine.

Purpose Of The Study: To compare the effect of loading doses of atorvastatin and rosuvastatin on the value of the acute kidney injury and acute inflammatory response to elective percutaneous coronary interventions.

Materials And Methods: An open prospective comparative study included 68 patients referred for elective percutaneous coronary intervention (PCI). At baseline, all patients had been taking statins for a long time as a standard lipid-lowering therapy. Read More

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[Optimization of digitalis therapy in clinical practice].

Kardiologiia 2018 SMay(S5):13-19

"M. Gorky Donetsk National Medical University" of the Ukraine Ministry of Health Care.

In recent years there has been a marked decrease in cardiac glycosides use in patients with heart failure in sinus rhythm and atrial fibrillation. The results of published studies contradict each other. Some of them doubt the favorable effect of digoxin in patients with heart failure; others refute the increase in the lethality and frequency of hospitalizations associated with the use of digoxin. Read More

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[Dosage forms and doses of acetylsalicylic acid: significance for clinical practice].

Authors:
E I Tarlovskaya

Kardiologiia 2018 SMay(S5):4-12

Federal State Budgetary Educational Institution of Higher Education, "Nizhny Novgorod State Medical Academy" of the Ministry of Health of the Russian Federation.

The article presents a review of pharmacokinetics and pharmacodynamics of different acetylsalicylic acid (ASA) dosage forms. The review showed that efficacy and safety of ASA are determined by its systemic effects and do not depend on the dosage form. Issues of ASA resistance are discussed. Read More

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Cardiomyocyte dimethylarginine dimethylaminohydrolase1 attenuates left-ventricular remodeling after acute myocardial infarction: involvement in oxidative stress and apoptosis.

Basic Res Cardiol 2018 Jun 11;113(4):28. Epub 2018 Jun 11.

Department of Cardiology, Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai, China.

Asymmetric dimethylarginine (ADMA) is a risk factor for heart diseases. Dimethylarginine dimethylaminohydrolase (DDAH) enzymes are key proteins for ADMA degradation. Endothelial DDAH1 is a vital regulator of angiogenesis. Read More

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June 2018
2 Reads

Inflammasome activation in AF.

Nat Rev Cardiol 2018 Jun 11. Epub 2018 Jun 11.

Nature Reviews Cardiology, .

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Coronary Artery Bypass Grafting-The Long-term Solution?

Can J Cardiol 2018 Mar 20. Epub 2018 Mar 20.

Department of Surgery, Max Rady College of Medicine, University of Manitoba, and Cardiac Sciences Program, St Boniface Hospital, Winnipeg, Manitoba, Canada. Electronic address:

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Breaking Barriers: Mobile Health Interventions for Cardiovascular Disease.

Can J Cardiol 2018 Jun 11. Epub 2018 Jun 11.

University of Sydney, Sydney, New South Wales, Australia; Department of Cardiology, Westmead Hospital, Sydney, New South Wales, Australia; The George Institute for Global Health, Sydney, New South Wales, Australia.

Cardiovascular disease (CVD) is a leading global cause of death and morbidity and prevention needs to be strengthened to tackle this. Mobile health (mHealth) might present a novel and effective solution in CVD prevention, and interest in mHealth has grown dramatically since the advent of the smartphone. In this review, we discuss mHealth interventions that target multiple cardiovascular risk factors simultaneously in the context of primary as well as secondary prevention. Read More

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Addition of Digoxin Improves Cardiac Function in Children With the Dilated Cardiomyopathy With Ataxia Syndrome: A Mitochondrial Cardiomyopathy.

Can J Cardiol 2018 Mar 1. Epub 2018 Mar 1.

Department of Pediatrics, Alberta Children's Hospital Research Institute, University of Calgary, Calgary, Alberta, Canada; Department of Medical Genetics, University of Calgary, Calgary, Alberta, Canada.

Background: The dilated cardiomyopathy with ataxia syndrome (DCMA) is a rare mitochondrial disorder characterized by progressive cardiomyopathy, prolonged QT interval and early death in childhood related to intractable heart failure. We present a case series of 9 children with DCMA who demonstrated functional improvement and favourable left ventricular remodeling only after digoxin was added to their medical therapy.

Methods: A retrospective review of 46 patients with DCMA followed at the Alberta Children's Hospital from 2005 to 2017 identified 9 patients who were treated with digoxin and had serial echocardiography data. Read More

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Atrial fibrillation and heart failure-associated remodeling of two-pore-domain potassium (K) channels in murine disease models: focus on TASK-1.

Basic Res Cardiol 2018 Jun 7;113(4):27. Epub 2018 Jun 7.

Department of Cardiology, University of Heidelberg, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany.

Understanding molecular mechanisms involved in atrial tissue remodeling and arrhythmogenesis in atrial fibrillation (AF) is essential for developing specific therapeutic approaches. Two-pore-domain potassium (K) channels modulate cellular excitability, and TASK-1 (K3.1) currents were recently shown to alter atrial action potential duration in AF and heart failure (HF). Read More

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June 2018
4 Reads

Citrulline Improves Early Post-Ischemic Recovery or Rat Hearts In Vitro by Shifting Arginine Metabolism From Polyamine to Nitric Oxide Formation.

Clin Med Insights Cardiol 2018 24;12:1179546818771908. Epub 2018 Apr 24.

Physiologisches Institut, Justus-Liebig-Universität Gießen, Gießen, Germany.

Background: Reperfusion or reopening of occluded vessels is the gold standard to terminate ischemia. However, early functional recovery after reperfusion is often low requiring inotropic intervention. Although catecholamines increase inotropy and chronotropy, they are not the best choice because they increase myocardial oxygen and substrate demand. Read More

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Associations of Grip Strength and Change in Grip Strength With All-Cause and Cardiovascular Mortality in a European Older Population.

Clin Med Insights Cardiol 2018 20;12:1179546818771894. Epub 2018 Apr 20.

College of Population Studies, Chulalongkorn University, Bangkok, Thailand.

Objective: (1) To examine the associations between 3 measures of grip strength: static grip strength, change in grip strength, and the combination of grip strength and its change, with all-cause and cardiovascular mortality, and (2) to determine which measure is the most powerful predictor of all-cause and cardiovascular mortality among the European older population.

Method: Data come from the first 4 waves of the Survey of Health, Ageing and Retirement in Europe (SHARE). A Cox proportional hazard model and a competing risk regression model were used to assess the associations. Read More

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Transcriptional regulation of the cardiac conduction system.

Nat Rev Cardiol 2018 Jun 6. Epub 2018 Jun 6.

Department of Medical Biology, Amsterdam Cardiovascular Sciences, Academic Medical Center, Amsterdam, Netherlands.

The rate and rhythm of heart muscle contractions are coordinated by the cardiac conduction system (CCS), a generic term for a collection of different specialized muscular tissues within the heart. The CCS components initiate the electrical impulse at the sinoatrial node, propagate it from atria to ventricles via the atrioventricular node and bundle branches, and distribute it to the ventricular muscle mass via the Purkinje fibre network. The CCS thereby controls the rate and rhythm of alternating contractions of the atria and ventricles. Read More

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June 2018
1 Read