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    In-Hospital ST-Segment Elevation Myocardial Infarction: Improving Diagnosis, Triage, and Treatment.
    JAMA Cardiol 2018 Feb 21. Epub 2018 Feb 21.
    Division of Cardiology, McAllister Heart Institute, University of North Carolina at Chapel Hill.
    Importance: In-hospital ST-segment elevation myocardial infarction (STEMI) is a unique clinical entity with epidemiology, incidence, and outcomes distinct from that of out-of-hospital STEMI and has only within the past 10 years begun to receive increased attention and research. Patients with in-hospital STEMI are older, have more comorbidities, and more frequently have coagulopathies and contraindications for anticoagulation and fibrinolytic therapy. A standardized clinical definition of in-hospital STEMI is lacking. Read More

    Cardiac Abnormalities in Patients With Hutchinson-Gilford Progeria Syndrome.
    JAMA Cardiol 2018 Feb 21. Epub 2018 Feb 21.
    Department of Cardiology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts.
    Importance: Hutchinson-Gilford progeria syndrome (HGPS) is an ultrarare disorder associated with premature death due to cardiovascular events during the second decade of life. However, because of its rarity (107 identified living patients), the natural history of cardiac disease remains uncharacterized. Therefore, meaningful cardiac end points for clinical trials have been difficult to establish. Read More

    [Lizinopril in the Treatment of Arterial Hypertension].
    Kardiologiia 2017 Sep;57(9):77-82
    Federal State Budgetary Educational Institution of Higher Education "I. M. Sechenov First Moscow State Medical University" of the Ministry of Health of the Russian Federation.
    Despite availability of a wide selection of antihypertensive drugs, only a small portion of patients with arterial hypertension are treated effectively. Angiotensin converting enzyme inhibitors (ACEI) are considered drugs of first choice for starting therapy of uncomplicated arterial hypertension. Among large number of representatives of this class lisinopril deserves special attention as one of best known and well-studied ACEIs. Read More

    [The Role of MicroRNA in Atherogenesis].
    Kardiologiia 2017 Sep;57(9):65-76
    Research Institute of Medical Genetics.
    This review provides modern data on the spectrum and the functional significance of micro-RNAs involved in atherogenesis and on some regulatory mechanisms that ensure the functioning of this class of molecules. We also outline some examples of micro-RNAs use as diagnostic and therapeutic targets. Read More

    [Current Echocardiographic Techniques for Evaluation of the Right Ventricle].
    Kardiologiia 2017 Sep;57(9):54-64
    Riga Stradiņš University.
    The review is dedicated to the new echocardiographic techniques in the assessment of right ventricular (RV) function, such as two-dimensional speckle tracking and determining the RV volume by a three-dimensional model. Subclinical changes in RV function are of great importance for the diagnosis and assessment of prognosis of multiple cardiovascular as well as non-cardiac pathologies. Two-dimensional speckle tracking allows to assess longitudinal strain of the RV myocardium and to detect pathological changes before their clinical manifestations. Read More

    [Randomized Comparison of Two Approaches to Initial Warfarin Dosing: Time in Therapeutic Range of International Normalized Ratio During Hospitalization].
    Kardiologiia 2017 Sep;57(9):42-46
    City clinical hospital No15 n.a. O. M. Filatov.
    Aim: To perform a randomized, open-label comparison of average time in therapeutic range (TTR) of international normalized ratio (INR) using two approaches to initial warfarin dosing during hospitalization: the standard method and the one using individual patient characteristics (clinical algorithm - the studied approach).

    Materials And Methods: We randomly assigned 60 patients with different indications for vitamin K antagonist therapy to the studied approach (n=31, intervention group) or to the standard method (n=29, control group). А target INR range for all patients was 2. Read More

    [Effects of High-Dose Statin Therapy on Cognitive Functions and Quality of Life in Very High Cardiovascular Risk Patients].
    Kardiologiia 2017 Sep;57(9):34-41
    Federal State Autonomous Educational Institution of Higher Education, "Peoples' Friendship University of Russia".
    Aim: To investigate the effects of intensive lipid-lowering therapy on cognitive functions and quality of life in patients (pts) with very high cardiovascular risk.

    Material And Methods: In 93 pts (58 men, 63.2±9. Read More

    [Head to Head Comparison of Suppression of Tumorogenicity 2 and Copeptin Significance for Prognosis of Patients After Acute Heart Failure Decompensation].
    Kardiologiia 2017 Sep;57(9):20-33
    Institute of Cardiology of Russian Cardiology Scientific and Production Complex.
    Purpose: To assess the suppression of tumorogenicity 2 (ST2) and copeptin significance for risk stratification of patient (pts) with acute decompensated heart failure (ADHF) during long-term follow-up compared with traditional risk factors.

    Methods: We included in a prospective study 159 pts with ADHF. Blood samples to determine copeptin, sST2, NT-proBNP and hsTnT concentration were collected at admission and at discharge from the hospital. Read More

    [Effect of Type 2 Diabetes Mellitus on Five‑Year Survival of Patients Hospitalized Because of Acute Decompensated Heart Failure].
    Kardiologiia 2017 Sep;57(9):14-19
    City clinical hospital No13.
    Objective: To assess the impact of type 2 diabetes mellitus (T2DM) on prognosis of patients hospitalized because of acute decompensated heart failure (ADHF).

    Materials And Methods: We analyzed data of the hospital register of ADHF which comprised information on 735 patients (254 [35%] with T2DM) consecutively admitted in 2010-2011. Median follow‑up was 1790 days. Read More

    [Structural and Functional Properties of the Left Atrium in Healthy Volunteers and Patients With Atrial Fibrillation: Data of Magnetic Resonance Imaging].
    Kardiologiia 2017 Sep;57(9):5-13
    Institute of Cardiology of Russian Cardiology Scientific and Production Complex.
    Background: in the recent years, there has been an increasing number of publications postulating that data on left atrial (LA) structure obtained by late gadolinium enhancement magnetic resonance imaging (LGE MRI) can improve the management of patients with atrial fibrillation (AF). At the same time, similar data regarding healthy LA myocardium is limited.

    Aim: to assess structural and functional properties of LA in healthy volunteers (HV) using cardiac magnetic resonance (CMR) (including LGE MRI); to compare these properties in patients with AF and HV. Read More

    [Takotsubo Cardiomyopathy as a Consequence of Myocardial Infarction. It is Possible?]
    Kardiologiia 2017 Dec;57(12):97-104
    State Budgetary Institution of Health Care "N. I. Pirogov Municipal Hospital #1 of the Moscow Health Care Department".
    Takotsubo cardiomyopathy (TCM) is a well-known complication of many conditions associated with emotional or physical stress. Abnormal catecholamine release has been hypothesized to be the main cause of TCM. Myocardial infarction (MI) is associated with release of large amounts of catecholamines. Read More

    [Clinical Aspects of Interventional Treatment of a Patient With Atrial Fibrillation Combined With Resistant Arterial Hypertension by the Method of Radiofrequency Ablation in Renal Arteries and Left Atrium].
    Kardiologiia 2017 Dec;57(12):90-96
    Federal State Budgetary Educational Institution of Higher Education "I. M. Sechenov First Moscow State Medical University" of the Ministry of Health of the Russian Federation.

    [Sudden Cardiac Death in Patients With Ischemic Heart Disease: From Mechanisms to Clinical Practice].
    Kardiologiia 2017 Dec;57(12):73-81
    Federal State Budgetary Institution, "A.N. Bakulev Science Center of Cardiovascular Surgery" of the RF Ministry of Health Care.
    Ischemic heart disease (IHD) and acute coronary syndrome are the main cause of sudden cardiac death (SCD). Incidence of SCD in patients after myocardial infarction (MI) is 4-6-fold higher than in general population. The review focuses on electrophysiological changes during acute myocardial ischemia and mechanisms of myocardial electromechanical remodeling in remote period after MI. Read More

    [24‑Hour Arterial Pressure Variability: Prognostic Significance, Methods of Evaluation, Effect of Antihypertensive Therapy].
    Kardiologiia 2017 Dec;57(12):62-72
    Federal State Budgetary Educational Institution of Higher Education, "A. I. Evdokimov Moscow State University for Medicine and Dentistry" of the Ministry of Health of the Russian Federation.
    We discuss in this article problems of prognostic significance of 24‑hour arterial pressure variability (24hAPV), as well as the role of 24hAPV in development and progression of various target organs damage by arterial hypertension. We also present literature data on impact of various regimens of antihypertensive therapy on 24hAPV, and on ability of fixed-dose perindopril/amlodipine to lower 24‑hAPV. Read More

    [The Role of Macrophages in Repair of Injured Myocardium and Perspectives of Metabolic Reprogramming of Immune Cells for Myocardial Post-Infarction Recovery].
    Kardiologiia 2017 Dec;57(12):53-59
    Institute of Cardiology of Russian Cardiology Scientific and Production Complex.
    A new trend in modern experimental cardiology is the development of approaches to correction of reparation after myocardial infarction (MI) with the use of specific effects on immune cells. One of the main targets for such interventions is the process of macrophage's polarization in the infarction zone. Proinflammatory M1‑macrophages contribute to hampered myocardial repair, in contrast to M2‑macrophages that promote regeneration. Read More

    [Elevated Level of the Natriuretic Peptide Among Adult Population in Regions Participating in the ESSE-RF Study and Its Association With Cardiovascular Diseases and Risk Factors].
    Kardiologiia 2017 Dec;57(12):43-52
    State Budgetary Institution of Health Care "National Research Center for Preventive Medicine" of the Ministry of Health of the Russian Federation.
    Aim: to study associations between elevated blood plasma concentration of N-terminal pro-brain natriuretic peptide (NT-proBNP), risk factors and cardiovascular diseases (CVD) in samples of adult population of Russian Federation (RF) aged 25-64 years.

    Materials And Methods: We analyzed data of examination of representative samples of population of 5 regions of RF obtained within the framework of the multicenter ESSE-RF study (2012-2013). Number of examined subjects was 8 077 (3 176 men). Read More

    [Awareness of the Risk Factors for Cardiovascular Disease in Different Types of Hospitalized Medical Patients].
    Kardiologiia 2017 Dec;57(12):34-42
    State Budgetary Institution of Health Care "National Research Center for Preventive Medicine" of the Ministry of Health of the Russian Federation.
    Objective: to study medical awareness of cardiovascular risk factors (FR) in hospitalized patients of the cardiac and internal medicine units (CU and IMU).

    Materials And Methods: A total of 100 patients from CU (n=50) and IMU (n=50) of a Moscow city hospital were included into the survey. The patients were interviewed during the I-II days of hospital stay. Read More

    [Hypertrophic Cardiomyopathy and Ischemic Heart Disease. Variants of Combination Pathology].
    Kardiologiia 2017 Dec;57(12):16-24
    Federal State Budgetary Educational Institution of Higher Education "I. M. Sechenov First Moscow State Medical University" of the Ministry of Health of the Russian Federation.
    The issues of epidemiology and pathophysiology of hypertrophic cardiomyopathy (HCMP), as well as the search for its additional clinical-instrumental and genetic markers, environmental factors capable to influence the formation of its clinical variant and prognosis are subjects of great interest to the modern scientific community. Besides genetic markers of main neurohumoral systems, and morphofunctional parameters of intracardiac hemodynamics clinical course of the disease is influenced by a complex of concomitant pathology including ischemic heart disease (IHD), joining of which is possible in 10% of cases. IHD substantially aggravates course of HCMP and hampers selection of medical therapy. Read More

    [Carotid Plaque Instability in Patients With Acute Coronary Syndrome as Assessed by Ultrasound Duplex Scanning].
    Kardiologiia 2017 Dec;57(12):5-15
    Institute of Cardiology of Russian Cardiology Scientific and Production Complex.
    Aim: to study carotid plaques structure in patients with acute coronary syndrome by ultrasound duplex scanning.

    Materials And Methods: We included in this study143 patients with acute coronary syndrome (ACS) aged 32-83 years and 28 patients with documented coronary heart disease (CHD) aged 46-83 years. Duplex scanning of carotid arteries was carried out with Philips iU22 ultrasound system and L9-3 linear array transducer. Read More

    [Basic Principles of Periprocedural Management of Patients With Nonvalvular Atrial Fibrillation Receiving Anticoagulant Therapy: the Consensus Document of Experts of the American College of Cardiology].
    Kardiologiia 2018 Feb(2):91-104
    Federal State Budgetary Educational Institution of Higher Education, "Pirogov Russian National Research Medical University " of the Ministry of Health of the Russian Federation, "Russian Gerontology Clinical Research Center".
    The article contains an outline of the 2017 ACC Expert Consensus Decision Pathway for Periprocedural Management of Anticoagulation in Patients With Nonvalvular Atrial Fibrillation. This document considers in detail problems of necessity and safety of temporary interrupting of anticoagulation for the period of procedure, main principles of interruption and restarting anticoagulant therapy after procedure, indications to the transitional (bridging) therapy in the periprocedural period, as well as possible strategies of periprocedural management of patients in dependence of risk of bleeding and thromboembolic complications. This Expert Consensus Decision Pathway refer to the periprocedural use of both oral (vitamin K antagonists, new oral anticoagulants) and parenteral (unfractionated and low-molecular-weight heparins) anticoagulants. Read More

    [Myocardial Infarction Due to Coronary Artery Embolism].
    Kardiologiia 2018 Feb(2):83-90
    Federal State Budgetary Educational Institution of Higher Education, "A. I. Evdokimov Moscow State University for Medicine and Dentistry" of the Ministry of Health of the Russian Federation.
    Coronary artery embolism (CAE) takes an important place among non-atherosclerotic causes of acute myocardial infarction (AMI). The features of embolic AMI are difficulties in diagnostics and absence of evidence-based guidelines for the management of CAE. Purpose of this review - to present synthesis of available data on embolic AMI. Read More

    [Use of Highly Concentrated Polyunsaturated Fatty Acids for Prevention of Complications After Myocardial Infarction. Cost-Utility Analysis].
    Kardiologiia 2018 Feb(2):77-82
    State Budgetary Educational Institution of Higher Professional Education, "I. I. Mechnikov North-West State Medical University" of the RF Ministry of Health Care.
    Use of highly concentrated ethyl esters of polyunsaturated fatty acids after myocardial infarction (MI) and in patients with heart failure was associated with lower mortality. The goal of this analysis was to perform cost-utility analysis of the use of highly concentrated ethyl esters of polyunsaturated fatty acids after MI (with help of a Markov model) and to find whether its use in some group of patients led to decrease in budget costs. As a result, we have shown that use of highly concentrated ethyl esters of polyunsaturated fatty acids after MI leads to increase in quality-adjusted life expectancy on 0. Read More

    [Antiaggregants in Primary Prevention of Cardiovascular Diseases and Prevention of Atherothrombosis in Patients With Stable Ischemic Heart Disease: Aspects of Efficacy and Safety].
    Kardiologiia 2018 Feb(2):55-67
    Federal State Budgetary Educational Institution of Higher Education "Saint-Petersburg State University".
    This review is devoted to the use of antiaggregants. We consider here pathogenesis of intraarterial thrombosis, mechanism of action of antiaggregants, and recommendations on the use of drugs of this class for primary prevention of cardiovascular diseases and prevention of atherothrombotic complications of stable ischemic heart disease. Information on mechanisms of development and causes of resistance to antiaggregants is also presented. Read More

    [Diverticula and Congenital Aneurysms of the Left Ventricle: Anatomical Features, Pathophysiology, Clinical Presentation and Treatment Strategy].
    Kardiologiia 2018 Feb(2):33-39
    Federal State Budgetary Institution "Academician E.N. Meshalkin Siberian Biomedical Research Center" of the Ministry of Health of the Russian Federation.
    Congenital aneurysms and diverticula of the left ventricle represent a rare group of anomalies in the spectrum of congenital heart disease. Although natural histories of these anomalies are considerably different and characterized by different rates of lifethreatening events, similarity of their clinical presentation and diagnostic criteria do not allow to differentiate this anomalies at routine examination. Data on etiology, methods of diagnosis and treatment published by various authors is controversial. Read More

    [Assessment of Vascular Stiffness in Normotensive Patients With Familial Hypercholesterolemia].
    Kardiologiia 2018 Feb(2):24-32
    Petrozavodsk State University.
    Aim: to analyze parameters of vascular stiffness and augmentation index in patients with familial hypercholesterolemia (FH).

    Materials And Methods: We compared parameters of vascular stiffness of 88 normotensive FH patients (mean age 41.95±1. Read More

    [Issues of Adipokine Regulation in Idiopathic Pulmonary Arterial Hypertension and Systemic Osteopenia].
    Kardiologiia 2018 Feb(2):17-23
    Vladivostok State Medical University.
    Purpose: to determine the role of adipokines and vascular remodeling in formation of osteoporosis in idiopathic pulmonary arterial hypertension (IPAH).

    Materials And Methods: Functional and hemodynamic parameters, bone mineral density (BMD) T-score in lumbar spine (LS) and femoral neck (FN), blood serum levels of leptin, adiponectin, visfatin and endothelin-1 were measured in 27 patients with severe IPAH and 30 healthy volunteers.

    Results: Half of IPAH patients had osteoporosis. Read More

    [Nerve Growth Factor in Patients With Arterial Hypertension: Neuropsychical, Hemodynamic, Metabolic Relationships].
    Kardiologiia 2018 Feb(2):10-16
    Medical Academy named after S. I. Georgievsky of V. I. Vernadsky Crimean Federal University.
    Aim: To investigate the changes of serum nerve growth factor (NGF) level in patients with arterial hypertension (AH) and obesity in dependence on the degree of psycho-emotional stress and physical activity.

    Materials And Methods: We examined 76 male patients with stage I and II AH with mean age 46.75±0. Read More

    [The Role of the I/D Polymorphism of the ACE Gene in the Development of Atrial Fibrillation].
    Kardiologiia 2018 Feb(2):5-9
    Krasnoyarsk State Medical University named after Prof. V. F. Vojno-Yasenetsky.
    Objective: To study associations of I / D polymorphism of the ACE gene with risk of atrial fibrillation (AF) with the aim of detecting groups of patients prone to development of this disease.

    Materials And Methods: We examined 90 probands with confirmed diagnosis of AF and 144 their I, II, III degrees relatives. These families constituted a core group of our study. Read More

    [The case of repeated syncopes in recurrent pulmonary embolism].
    Kardiologiia 2017 SMar;57(S3):76-80
    Municipal Clinical Hospital #23, Donetsk.
    The article provides a case report of recurrent syncopal episodes in a 57-year old male patient. During a three-month period of recurrent syncope, the patient was managed by the family doctor and at pulmonology and cardiology departments for different diagnoses. Due to an uncertainty in diagnosis, the patient was moved to a hospital where he underwent echocardiographic examination and duplex scanning of right leg veins, which detected a 49. Read More

    [Factors associated with levels of interleukins -18, -8, and -6 in hypertensive patients at high and very high cardiovascular risk].
    Kardiologiia 2017 SMar;57(S3):69-75
    Federal State Budgetary Educational Institution of Higher Education, "Pirogov Russian National Research Medical University" of the Ministry of Health of the Russian Federation.
    Aim: To identify the most significant factor influencing blood levels of cytokines in patients at high and very high cardiovascular risk.

    Materials And Methods: A patient base from the "Management of chronic patients with multiple diseases" project was analyzed. 523 patients (mean age, 87±17. Read More

    [Effectiveness of a long-term education program in patients with prosthetic heart valves].
    Kardiologiia 2017 SMar;57(S3):62-68
    "Research Institute for Complex Issues of Cardiovascular Diseases", Federal Agency for Scientific Organizations.
    Aim: The current study was aimed at assessing the effectiveness and the impact of a long-term education program, in both inpatient and outpatient treatment settings, on adherence to treatment and the quality of life 5 years after heart valve replacement.

    Materials And Methods: All the patients were randomly included into two study groups. The study group patients (n=176) underwent the long-term education program in both inpatient and outpatient treatment settings. Read More

    [Disorders of heart structure and function parameters and hepatolienal blood flow remodeling in patients with virus-induced cirrhosis].
    Kardiologiia 2017 SMar;57(S3):57-61
    Federal State Budgetary Educational Institution of Higher Professional Education "Chita State Medical Academy" of the Ministry of Health of the Russian Federation.
    Aim: To study heart structure and function parameters and hepatolienal blood flow in patients with virus-induced cirrhosis (VIC).

    Materials And Methods: 95 patients with VIC (mean age, 38.6; disease duration, 4. Read More

    [Interventional treatment in patients with myocarditis: Pro and Contra].
    Kardiologiia 2017 SMar;57(S3):49-56
    Federal State Budgetary Institution "Federal Almazov North-West Medical Research Center" of the Ministry of Health of the Russian Federation.
    Aim: Ventricular tachyarrhythmias (VTs) are often encountered in patients with inflammatory heart diseases. VT can become lifethreatening in patients with myocarditis, and the management may vary in different types of myocarditis. Purpose of the study is to describe VT characteristics in patients with verified myocarditis, and to evaluate the efficacy and safety of VT management, when tailored to the type of myocarditis. Read More

    [Incidence of sinus node dysfunction in patients with long-standing, persistent atrial fibrillation who require simultaneous surgical correction of mitral and tricuspid valve defects and the "Maze IIIB" procedure].
    Kardiologiia 2017 SMar;57(S3):40-48
    Federal State Budgetary Institution, "A.N. Bakulev Science Center of Cardiovascular Surgery" of the RF Ministry of Health Care.
    Background: Atrial fibrillation (AF) is the most common disorder of heart rhythm. A series of "Maze" surgery was developed, among which the "Maze III" modification is presently a gold standard for surgical treatment of AF.

    Aim: To study the sinoatrial node (SAN) function before and after the "Maze III" surgery. Read More

    [The clinical significance of copeptin and matrix metalloproteinases in men with acute coronary syndrome].
    Kardiologiia 2017 SMar;57(S3):32-39
    Territorial State Budgetary Institution of Health Care "Altai regional cardiological dispensary".
    Aim: To evaluate clinical value copeptin and matrix metalloproteinases in men with acute coronary syndrome (ACS).

    Materials And Methods: The study included 152 men with ACS. After evaluation of the traditional markers of myocardial damage, the patients were divided into 2 groups: the first group included patients with myocardial infarction (MI) - 84 people, the average age was 56. Read More

    [Safety and efficacy of long-term treatment with different ASA forms in patients with stable IHD and a high risk for development of gastropathy by data from a cross-sectionals study].
    Kardiologiia 2017 SMar;57(S3):24-31
    Federal State Budgetary Educational Institution of Higher Education, "Nizhny Novgorod State Medical Academy" of the Ministry of Health of the Russian Federation.
    Aim: To study indexes of efficacy, safety and compliance for different ASA forms (Aspirin-Cardio, Cardiomagnyl, Thrombo ASS) used in stable IHD.

    Materials And Methods: An open, cross-sectional study compared three groups of patients consisting of 200 patients each who had stable IHD and a high risk of gastrointestinal disorders and who received a long-term antiaggregant monotherapy with one of ASA drugs (group 1, Aspirin Cardio; group 2, Thrombo ASS; group 3, Cardiomagnyl). Efficacy, safety and compliance with the treatment were evaluated using standard tests and analogue scales; dyspepsia symptoms were evaluated using a special, additionally developed questionnaire. Read More

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