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    29921 results match your criteria Cardiology[Journal]

    1 OF 599

    The NLRP3 inflammasome in acute myocardial infarction.
    Nat Rev Cardiol 2017 Nov 16. Epub 2017 Nov 16.
    Pauley Heart Center, Sanger Hall, 1201 East Marshall Street, Richmond, Virginia 23298, USA.
    The heart is extremely sensitive to ischaemic injury. During an acute myocardial infarction (AMI) event, the injury is initially caused by reduced blood supply to the tissues, which is then further exacerbated by an intense and highly specific inflammatory response that occurs during reperfusion. Numerous studies have highlighted the central role of the NACHT, LRR, and PYD domains-containing protein 3 (NLRP3) inflammasome in this process. Read More

    Next-generation pacemakers: from small devices to biological pacemakers.
    Nat Rev Cardiol 2017 Nov 16. Epub 2017 Nov 16.
    Cedars-Sinai Heart Institute, 8700 Beverly Boulevard, Los Angeles, California 90048, USA.
    Electrogenesis in the heart begins in the sinoatrial node and proceeds down the conduction system to originate the heartbeat. Conduction system disorders lead to slow heart rates that are insufficient to support the circulation, necessitating implantation of electronic pacemakers. The typical electronic pacemaker consists of a subcutaneous generator and battery module attached to one or more endocardial leads. Read More

    The RISK pathway and beyond.
    Basic Res Cardiol 2017 Nov 15;113(1). Epub 2017 Nov 15.
    The Hatter Cardiovascular Institute, University College London, 67 Chenies Mews, London, WC1E 6HX, UK.
    Research on cardioprotection has attracted considerable attention during the past 30 years following the discovery of ischemic preconditioning with great advances being made in the field, particularly in the description of the molecular signalling behind this cardioprotective intervention. In a time when basic research is struggling to translate its findings into therapies in the clinical setting, this viewpoint has the intention of presenting to clinical and basic scientists how the reperfusion injury salvage kinase pathway has been described and dissected, as well as highlighting its relevance in cardioprotection. Read More

    MMP-9 and Its Regulators TIMP-1 and EMMPRIN in Patients with Acute ST-Elevation Myocardial Infarction: A NORDISTEMI Substudy.
    Cardiology 2017 Nov 16;139(1):17-24. Epub 2017 Nov 16.
    Center for Clinical Heart Research, Oslo University Hospital Ullevål, Oslo, Norway.
    Objectives: The extracellular matrix is involved in wound repair after acute myocardial infarction (AMI). We investigated whether matrix metalloproteinase (MMP)-9, tissue inhibitor of metalloproteinases (TIMP)-1, and the MMP inducer (EMMPRIN) are associated with infarct size, left ventricular function, and clinical outcome in ST-elevation-MI (STEMI).

    Methods: In 243 STEMI patients, circulating EMMPRIN, MMP-9, and TIMP-1 were analyzed 3 days and 3 months post-AMI. Read More

    Association of CETP Gene Variants With Risk for Vascular and Nonvascular Diseases Among Chinese Adults.
    JAMA Cardiol 2017 Nov 15. Epub 2017 Nov 15.
    Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, England.
    Importance: Increasing levels of high-density lipoprotein (HDL) cholesterol through pharmacologic inhibition of cholesteryl ester transfer protein (CETP) is a potentially important strategy for prevention and treatment of cardiovascular disease (CVD).

    Objective: To use genetic variants in the CETP gene to assess potential risks and benefits of lifelong lower CETP activity on CVD and other outcomes.

    Design, Setting, And Participants: This prospective biobank study included 151 217 individuals aged 30 to 79 years who were enrolled from 5 urban and 5 rural areas of China from June 25, 2004, through July 15, 2008. Read More

    Usefulness of Total 12-Lead QRS Voltage as a Clue to Diagnosis of Patients With Cardiac Sarcoidosis Severe Enough to Warrant Orthotopic Heart Transplant.
    JAMA Cardiol 2017 Nov 15. Epub 2017 Nov 15.
    Baylor Heart and Vascular Institute, Baylor University Medical Center at Dallas, Dallas, Texas.
    Importance: Severe heart failure caused by cardiac sarcoidosis is difficult to diagnosis without biopsy.

    Objective: To assess whether total electrocardiographic 12-lead QRS voltage may be a clue to diagnosis.

    Design, Setting, Participants: Case-series study with cases collected at Baylor University Medical Center at Dallas, Dallas, Texas, from January 13, 2005, to January 24, 2017. Read More

    Shift Work and the Risk of Coronary Artery Disease: A Cardiac Computed Tomography Angiography Study.
    Cardiology 2017 Nov 2;139(1):11-16. Epub 2017 Nov 2.
    Department of Cardiology, Tel Aviv Medical Center, affiliated to Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.
    Aims: Shift work disrupts the normal circadian rhythm and is associated with risk factors for coronary artery disease (CAD) and a higher incidence of CAD morbidity and mortality. Cardiac computed tomography angiography (CCTA) is a robust noninvasive modality for assessing the presence, extent, and severity of CAD. We sought to investigate whether shift workers are prone to a higher burden of CAD compared to non-shift workers. Read More

    Association of the Hospital Readmissions Reduction Program Implementation With Readmission and Mortality Outcomes in Heart Failure.
    JAMA Cardiol 2017 Nov 12. Epub 2017 Nov 12.
    Division of Cardiology, Ahmanson-UCLA (University of California, Los Angeles) Cardiomyopathy Center, Ronald Reagan-UCLA Medical Center, Los Angeles.
    Importance: Public reporting of hospitals' 30-day risk-standardized readmission rates following heart failure hospitalization and the financial penalization of hospitals with higher rates have been associated with a reduction in 30-day readmissions but have raised concerns regarding the potential for unintended consequences.

    Objective: To examine the association of the Hospital Readmissions Reduction Program (HRRP) with readmission and mortality outcomes among patients hospitalized with heart failure within a prospective clinical registry that allows for detailed risk adjustment.

    Design, Setting, And Participants: Interrupted time-series and survival analyses of index heart failure hospitalizations were conducted from January 1, 2006, to December 31, 2014. Read More

    Association of LPA Variants With Aortic Stenosis: A Large-Scale Study Using Diagnostic and Procedural Codes From Electronic Health Records.
    JAMA Cardiol 2017 Nov 12. Epub 2017 Nov 12.
    Department of Medicine, McGill University, Montreal, Quebec, Canada.
    Importance: Elevated lipoprotein(a) levels are a risk factor for aortic stenosis (AS). However, a large-scale replication of associations between LPA variants and AS, their interactions with risk factors, and the effect of multiple risk alleles is not well established.

    Objective: To replicate the association between LPA variants with AS and identify subgroups who are at higher risk of developing AS. Read More

    Association of Atrial Fibrillation Clinical Phenotypes with Treatment Patterns and Outcomes: A Multicenter Registry Study.
    JAMA Cardiol 2017 Nov 12. Epub 2017 Nov 12.
    Duke Clinical Research Institute, Duke University Medical Center, Durham, North Carolina.
    Importance: Atrial fibrillation (AF) is usually classified on the basis of the disease subtype. However, this characterization does not capture the full heterogeneity of AF, and a data-driven cluster analysis reveals different possible classifications of patients.

    Objective: To characterize patients with AF based on a cluster analysis and to evaluate the association between these phenotypes, treatment, and clinical outcomes. Read More

    Association of Physical Activity With Risk of Major Cardiovascular Diseases in Chinese Men and Women.
    JAMA Cardiol 2017 Nov 8. Epub 2017 Nov 8.
    Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, England.
    Importance: In China, the patterns and levels of physical activity differed from those in high-income countries. Substantial uncertainty remains about the relevance, both qualitatively and quantitatively, of domain-specific physical activity for cardiovascular disease (CVD) subtypes in Chinese adults.

    Objective: To assess the shape and strength of the associations of total, occupational, and nonoccupational physical activity with CVD subtypes in Chinese men and women. Read More

    Role of Hospital Volumes in Identifying Low-Performing and High-Performing Aortic and Mitral Valve Surgical Centers in the United States.
    JAMA Cardiol 2017 Nov 8. Epub 2017 Nov 8.
    Division of Cardiology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas.
    Importance: Identifying high-performing surgical valve centers with the best surgical outcomes is challenging. Hospital surgical volume is a frequently used surrogate for outcomes. However, its ability to distinguish low-performing and high-performing hospitals remains unknown. Read More

    Clinical Efficacy and Safety of Evolocumab in High-Risk Patients Receiving a Statin: Secondary Analysis of Patients With Low LDL Cholesterol Levels and in Those Already Receiving a Maximal-Potency Statin in a Randomized Clinical Trial.
    JAMA Cardiol 2017 Nov 8. Epub 2017 Nov 8.
    TIMI (Thrombolysis in Myocardial Infarction) Study Office, Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
    Importance: Current guidelines for atherosclerotic cardiovascular disease focus on high-intensity statins and targeting or using a threshold low-density lipoprotein cholesterol (LDL-C) level of less than 70 mg/dL for the highest-risk patients. Whether further reduction of LDL-C beyond these boundaries would be beneficial is unknown.

    Objective: To compare outcomes of evolocumab vs placebo in patients with stable atherosclerotic cardiovascular disease and a baseline LDL-C of less than 70 mg/dL and in those receiving background treatment with a maximal-potency statin. Read More

    Coronary Artery Calcium Score for Long-term Risk Classification in Individuals With Type 2 Diabetes and Metabolic Syndrome From the Multi-Ethnic Study of Atherosclerosis.
    JAMA Cardiol 2017 Nov 8. Epub 2017 Nov 8.
    Division of Cardiology, Department of Medicine, University of California, Irvine.
    Importance: Although the risk of type 2 diabetes is considered to be equivalent to coronary heart disease (CHD) risk, there is considerable heterogeneity among individuals for CHD and atherosclerotic cardiovascular disease (ASCVD) risk. It is not known whether coronary artery calcium (CAC) assessment at baseline in individuals with established metabolic syndrome (MetS) or diabetes identifies CHD and ASCVD prognostic indicators during a long follow-up period.

    Objective: To compare improvement in long-term prognostication of incident CHD and ASCVD using CAC scores among those with diabetes, MetS, or neither condition. Read More

    Impact of Injectable Furosemide Hospital Shortage on Congestive Heart Failure Outcomes: A Time Series Analysis.
    Can J Cardiol 2017 Nov 12;33(11):1498-1504. Epub 2017 Sep 12.
    Division of Nephrology, Western University, London, Ontario, Canada; Institute for Clinical Evaluative Sciences (ICES), Toronto, Ontario, Canada; Department of Epidemiology and Biostatistics, Western University, London, Ontario, Canada. Electronic address:
    Background: Beginning in February 2012, there was a shortage of injectable furosemide in the province of Ontario, Canada. The objective of this study was to assess the effects of the furosemide shortage on heart failure outcomes in Ontario, Canada.

    Methods: We determined which hospitals experienced a shortage of injectable furosemide using an online survey. Read More

    Mind the Gap: Current Challenges and Future State of Heart Failure Care.
    Can J Cardiol 2017 Nov 5;33(11):1434-1449. Epub 2017 Sep 5.
    Department of Medicine, Division of Cardiology, University of British Columbia, Vancouver, British Columbia, Canada.
    The past decade has seen many advances in the management of heart failure (HF) that have improved survival and quality of life for patients living with this condition. A number of gaps remain in our understanding of the pathophysiology of HF, and the application of emerging treatment strategies is an exciting but daunting challenge. It is possible that advances in genetic evaluation of cardiomyopathy will provide a more refined approach to characterizing HF syndromes, whereas large-scale clinical trials on the horizon should further clarify the role of novel pharmacologic agents and invasive therapies. Read More

    2017 Comprehensive Update of the Canadian Cardiovascular Society Guidelines for the Management of Heart Failure.
    Can J Cardiol 2017 Nov 6;33(11):1342-1433. Epub 2017 Sep 6.
    Memorial University, St John's, Newfoundland, Canada.
    Since the inception of the Canadian Cardiovascular Society heart failure (HF) guidelines in 2006, much has changed in the care for patients with HF. Over the past decade, the HF Guidelines Committee has published regular updates. However, because of the major changes that have occurred, the Guidelines Committee believes that a comprehensive reassessment of the HF management recommendations is presently needed, with a view to producing a full and complete set of updated guidelines. Read More

    Recurrent Strokes After Gore Septal Occluder Device Closure of Atrial Septal Defect.
    Can J Cardiol 2017 Sep 1. Epub 2017 Sep 1.
    Division of Pediatric Cardiology, Izaak Walton Killam Health Centre/Dalhousie University Faculty of Medicine, Halifax, Nova Scotia, Canada. Electronic address:
    We report a case of recurrent strokes in a healthy teenager after complete closure of atrial septal defect with Gore Septal Occluder (W.L. Gore and Associates, Newark, DE) device. Read More

    Timing of Conduction Abnormalities Leading to Permanent Pacemaker Insertion After Transcatheter Aortic Valve Implantation-A Single-Centre Review.
    Can J Cardiol 2017 Sep 1. Epub 2017 Sep 1.
    University of Toronto, Toronto, Ontario, Canada; Division of Cardiology and Cardiac Surgery, Schulich Heart Centre, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada; Institute for Clinical Evaluative Sciences (ICES), Toronto, Ontario, Canada; Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, Ontario, Canada. Electronic address:
    Background: Transcatheter aortic valve implantation (TAVI) is the preferred alternative to traditional surgical aortic valve replacement; however, it remains expensive. One potential driver of cost is the need for postprocedural monitoring for conduction abnormalities after TAVI. Given the paucity of literature on the optimal length of monitoring, we aimed to determine when clinically significant conduction abnormalities leading to permanent pacemaker (PPM) insertion after TAVI were first identified. Read More

    Syncope and Presyncope as a Presenting Symptom or Discharge Diagnosis in the Emergency Department: An Administrative Data Validation Study.
    Can J Cardiol 2017 Sep 11. Epub 2017 Sep 11.
    Centre for Clinical Epidemiology & Evaluation, Vancouver, British Columbia, Canada; Department of Emergency Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
    Emergency department (ED) visits for syncope are common. Validation of ED administrative diagnostic coding for syncope is required before these codes can be used for health services research. We performed a retrospective multicentre chart review using a regional ED database in British Columbia. Read More

    Autonomic Dysfunction in Cardiology: Pathophysiology, Investigation, and Management.
    Can J Cardiol 2017 Sep 14. Epub 2017 Sep 14.
    Department of Cardiac Sciences, Libin Cardiovascular Institute of Alberta, University of Calgary, Calgary, Alberta, Canada; Autonomic Dysfunction Center, Division of Clinical Pharmacology, Vanderbilt University Medical Center, Nashville, Tennessee, USA. Electronic address:
    Presyncope and syncope are common medical findings, with a > 40% estimated lifetime prevalence. These conditions are often elicited by postural stress and can be recurrent and accompanied by debilitating symptoms of cerebral hypoperfusion. Therefore, it is critical for physicians to become familiar with the diagnosis and treatment of common underlying causes of presyncope and syncope. Read More

    Periostin in cardiovascular disease and development: a tale of two distinct roles.
    Basic Res Cardiol 2017 Nov 3;113(1). Epub 2017 Nov 3.
    Department of Physiology and Pathophysiology, Rady Faculty of Health Sciences, Max Rady College of Medicine, Institute of Cardiovascular Sciences, University of Manitoba, Winnipeg, Canada.
    Tissue development and homeostasis are dependent upon the concerted synthesis, maintenance, and degradation of extracellular matrix (ECM) molecules. Cardiac fibrosis is now recognized as a primary contributor to incidence of heart failure, particularly heart failure with preserved ejection fraction, wherein cardiac filling in diastole is compromised. Periostin is a cell-associated protein involved in cell fate determination, proliferation, tumorigenesis, and inflammatory responses. Read More

    Racial Differences in Prevalence and Risk for Intracranial Atherosclerosis in a US Community-Based Population.
    JAMA Cardiol 2017 Nov 1. Epub 2017 Nov 1.
    The Russell H. Morgan Department of Radiology & Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, Maryland.
    Importance: Intracranial atherosclerotic disease (ICAD) is an important cause of stroke; however, little is known about racial differences in ICAD prevalence and its risk factors.

    Objective: To determine racial differences in ICAD prevalence and the risk factors (both midlife and concurrent) associated with its development in a large, US community-based cohort.

    Design, Setting, And Participants: Analysis of 1752 black and white participants recruited from the Atherosclerosis Risk in Communities (ARIC) cohort study who underwent 3-dimensional intracranial vessel wall magnetic resonance imaging from October 18, 2011 to December 30, 2013; data analysis was performed from October 18, 2011 to May 13, 2015. Read More

    Association of Serial Kansas City Cardiomyopathy Questionnaire Assessments With Death and Hospitalization in Patients With Heart Failure With Preserved and Reduced Ejection Fraction: A Secondary Analysis of 2 Randomized Clinical Trials.
    JAMA Cardiol 2017 Nov 1. Epub 2017 Nov 1.
    University of Missouri, Kansas City.
    Importance: While there is increasing emphasis on incorporating patient-reported outcome measures in routine care for patients with heart failure (HF), how best to interpret longitudinally collected patient-reported outcome measures is unknown.

    Objective: To examine the strength of association between prior, current, or a change in Kansas City Cardiomyopathy Questionnaire (KCCQ) scores with death and hospitalization in patients with HF with preserved (HFpEF) and reduced (HFrEF) ejection fractions.

    Design, Setting, And Participants: Secondary analyses of the Treatment of Preserved Cardiac Function Heart Failure With an Aldosterone Antagonist (TOPCAT) trial of 1372 patients with HFpEF, conducted between August 2006 and January 2012, and the HF-ACTION trial that included 1669 patients with HFrEF, conducted between April 2003 and February 2007. Read More

    Development of Mitral Stenosis After Mitral Valve Repair: Importance of Mitral Valve Area.
    Can J Cardiol 2017 Sep 11. Epub 2017 Sep 11.
    University of Ottawa Heart Institute, Ottawa, Ontario, Canada.
    Background: The development of mitral stenosis (MS) is not uncommon after mitral valve (MV) repair for degenerative mitral regurgitation (MR), but the significance of MS in this setting has not been defined.

    Methods: We prospectively studied 110 such patients who underwent supine bicycle exercise testing to assess intracardiac hemodynamics at rest and at peak exercise. B-type natriuretic peptide (BNP) levels were measured at rest and after the exercise test. Read More

    Regenerating the human heart: direct reprogramming strategies and their current limitations.
    Basic Res Cardiol 2017 Oct 27;112(6):68. Epub 2017 Oct 27.
    Stem Cells for Tissue Engineering Lab, IRCCS Policlinico San Donato, Piazza Malan 2, San Donato Milanese, 20097, Milan, Italy.
    Cardiovascular diseases are the leading cause of death in the Western world. Unfortunately, current therapies are often only palliative, consequently essentially making heart transplantation necessary for many patients. However, several novel therapeutic approaches in the past two decades have yielded quite encouraging results. Read More

    Effect of long-term remote ischemic conditioning in patients with chronic ischemic heart failure.
    Basic Res Cardiol 2017 Oct 25;112(6):67. Epub 2017 Oct 25.
    Department of Cardiology, Aarhus University Hospital, Palle Juul-Jensens Boulevard 99, Aarhus N, 8200, Aarhus, Denmark.
    Remote ischemic conditioning (RIC) protects against acute ischemia-reperfusion injury and may also have beneficial effects in patients with stable cardiovascular disease. We investigated the effect of long-term RIC treatment in patients with chronic ischaemic heart failure (CIHF). In a parallel group study, 22 patients with compensated CIHF and 21 matched control subjects without heart failure or ischemic heart disease were evaluated by cardiac magnetic resonance imaging, cardiopulmonary exercise testing, skeletal muscle function testing, blood pressure measurement and blood sampling before and after 28 ± 4 days of once daily RIC treatment. Read More

    Prognostic Effect and Longitudinal Hemodynamic Assessment of Borderline Pulmonary Hypertension.
    JAMA Cardiol 2017 Oct 25. Epub 2017 Oct 25.
    Vanderbilt Center for Translational and Clinical Cardiovascular Research, Vanderbilt University School of Medicine, Nashville, Tennessee.
    Importance: Pulmonary hypertension (PH) is diagnosed by a mean pulmonary arterial pressure (mPAP) value of at least 25 mm Hg during right heart catheterization (RHC). While several studies have demonstrated increased mortality in patients with mPAP less than that threshold, little is known about the natural history of borderline PH.

    Objective: To test the hypothesis that patients with borderline PH have decreased survival compared with patients with lower mPAP and frequently develop overt PH and to identify clinical correlates of borderline PH. Read More

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