31,416 results match your criteria Cardiology[Journal]


Postoperative atrial fibrillation: mechanisms, manifestations and management.

Nat Rev Cardiol 2019 Feb 21. Epub 2019 Feb 21.

Department of Medicine and Research Center, Montreal Heart Institute and Université de Montréal, Montreal, Quebec, Canada.

Postoperative atrial fibrillation (POAF) complicates 20-40% of cardiac surgical procedures and 10-20% of non-cardiac thoracic operations. Typical features include onset at 2-4 days postoperatively, episodes that are often fleeting and a self-limited time course. Associated adverse consequences of POAF include haemodynamic instability, increased risk of stroke, lengthened hospital and intensive care unit stays and greater costs. Read More

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http://dx.doi.org/10.1038/s41569-019-0166-5DOI Listing
February 2019

Protein kinase/phosphatase balance mediates the effects of increased late sodium current on ventricular calcium cycling.

Basic Res Cardiol 2019 02 20;114(2):13. Epub 2019 Feb 20.

Abt. Kardiologie und Pneumologie/Herzzentrum, Georg-August-Universität Göttingen, Robert-Koch-Str. 40, 37075, Göttingen, Germany.

Increased late sodium current (late I) is an important arrhythmogenic trigger in cardiac disease. It prolongs cardiac action potential and leads to an increased SR Ca leak. This study investigates the contribution of Ca/Calmodulin-dependent kinase II (CaMKII), protein kinase A (PKA) and conversely acting protein phosphatases 1 and 2A (PP1, PP2A) to this subcellular crosstalk. Read More

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http://dx.doi.org/10.1007/s00395-019-0720-7DOI Listing
February 2019

Evaluating Treatment Effect of Transcatheter Interatrial Shunt Device Using Heart Failure Event Rates.

JAMA Cardiol 2019 Feb 20. Epub 2019 Feb 20.

Department of Biostatistics, Harvard T. H. Chan School of Public Health, Boston, Massachusetts.

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http://dx.doi.org/10.1001/jamacardio.2019.0001DOI Listing
February 2019

JAMA Cardiology.

Authors:

JAMA Cardiol 2019 Feb;4(2):90

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http://dx.doi.org/10.1001/jamacardio.2018.3181DOI Listing
February 2019

The Future of Registries in the Era of Real-world Evidence for Medical Devices.

JAMA Cardiol 2019 Feb 20. Epub 2019 Feb 20.

US Food and Drug Administration, Silver Spring, Maryland.

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http://dx.doi.org/10.1001/jamacardio.2018.4933DOI Listing
February 2019

Evaluating Treatment Effect of Transcatheter Interatrial Shunt Device Using Heart Failure Event Rates-Reply.

JAMA Cardiol 2019 Feb 20. Epub 2019 Feb 20.

Boston University School of Public Health, Boston, Massachusetts.

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http://dx.doi.org/10.1001/jamacardio.2019.0004DOI Listing
February 2019

Observational Outcomes or Use of Guideline Recommended Treatments?: Which Demonstrates Better Care?

Authors:
Paul Heidenreich

JAMA Cardiol 2019 Feb 20. Epub 2019 Feb 20.

Veterans Affairs Palo Alto Health Care System, Palo Alto, California.

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http://dx.doi.org/10.1001/jamacardio.2019.0050DOI Listing
February 2019

Differences in Management of Coronary Artery Disease in Patients With Medicare Advantage vs Traditional Fee-for-Service Medicare Among Cardiology Practices.

JAMA Cardiol 2019 Feb 20. Epub 2019 Feb 20.

Cardiovascular Division, Department of Medicine, Washington University in St Louis School of Medicine, St Louis, Missouri.

Importance: One-third of Medicare beneficiaries are enrolled in Medicare Advantage (MA), Medicare's private plan option. Medicare Advantage incentivizes performance on evidence-based care, but limited information exists using reliable clinical data to determine whether this translates into better quality for patients with coronary artery disease (CAD) enrolled in MA compared with those enrolled in traditional fee-for-service (FFS) Medicare.

Objective: To determine differences in evidence-based secondary prevention treatments and intermediate outcomes among patients with CAD enrolled in MA vs FFS Medicare. Read More

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http://dx.doi.org/10.1001/jamacardio.2019.0007DOI Listing
February 2019

T cells in the gut promote CVD and slow metabolism.

Nat Rev Cardiol 2019 Feb 19. Epub 2019 Feb 19.

Nature Reviews Cardiology, .

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http://dx.doi.org/10.1038/s41569-019-0173-6DOI Listing
February 2019

IL-1 signalling in atherosclerosis.

Authors:
Gregory B Lim

Nat Rev Cardiol 2019 Feb 19. Epub 2019 Feb 19.

Nature Reviews Cardiology, .

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http://dx.doi.org/10.1038/s41569-019-0172-7DOI Listing
February 2019

Statin efficacy in primary CVD prevention might diminish with patient age.

Nat Rev Cardiol 2019 Feb 19. Epub 2019 Feb 19.

Nature Reviews Cardiology, .

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http://dx.doi.org/10.1038/s41569-019-0171-8DOI Listing
February 2019

T cell co-stimulation and co-inhibition in cardiovascular disease: a double-edged sword.

Nat Rev Cardiol 2019 Feb 15. Epub 2019 Feb 15.

Department of Surgery, Leiden University Medical Center, Leiden, Netherlands.

The role of inflammation in cardiovascular disease (CVD) is now widely accepted. Immune cells, including T cells, are influenced by inflammatory signals and contribute to the onset and progression of CVD. T cell activation is modulated by T cell co-stimulation and co-inhibition pathways. Read More

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http://dx.doi.org/10.1038/s41569-019-0164-7DOI Listing
February 2019
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The different response of cardiomyocytes and cardiac fibroblasts to mitochondria inhibition and the underlying role of STAT3.

Basic Res Cardiol 2019 02 14;114(2):12. Epub 2019 Feb 14.

Department of Pharmacology (the State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education), College of Pharmacy, Harbin Medical University, Baojian Road 157, Harbin, 150086, People's Republic of China.

Cardiomyocyte loss and cardiac fibrosis are the main characteristics of cardiac ischemia and heart failure, and mitochondrial function of cardiomyocytes is impaired in cardiac ischemia and heart failure, so the aim of this study is to identify fate variability of cardiomyocytes and cardiac fibroblasts with mitochondria inhibition and explore the underlying mechanism. The mitochondrial respiratory function was measured by using Oxygraph-2k high-resolution respirometry. The STAT3 expression and activity were evaluated by western blot. Read More

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http://dx.doi.org/10.1007/s00395-019-0721-6DOI Listing
February 2019
1 Read

Enormous Aneurysm in Coronary Artery Fistula With Immunoglobulin G4-Related Disease.

Can J Cardiol 2019 Feb 5;35(2):230.e1-230.e3. Epub 2018 Dec 5.

Department of Cardiovascular Medicine, The University of Tokyo Hospital, Tokyo, Japan.

We report the first case of coronary artery fistula with aneurysmal change in a patient with immunoglobulin G4-related disease (IgG4-RD). This case revealed concomitant coronary artery dilation, pericardial inflammatory nodules, and coronary-pulmonary fistula aneurysm in addition to several IgG4-RD lesions. Each of these features was located in close proximity to the thickened pericardium. Read More

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http://dx.doi.org/10.1016/j.cjca.2018.11.030DOI Listing
February 2019
1 Read

Stress-Induced Cardiomyopathy Complicated by Dynamic Left Ventricular Outflow Obstruction, Cardiogenic Shock, and Ventricular Septal Rupture.

Can J Cardiol 2019 Feb 7;35(2):229.e7-229.e9. Epub 2018 Dec 7.

Department of Cardiovascular Sciences, University of South Florida, Morsani College of Medicine, Tampa, Florida, USA. Electronic address:

We describe the case of a 68-year-old woman presenting with stress cardiomyopathy (SCM), with concomitant cardiogenic shock, left ventricular outflow tract obstruction, and ventricular septal rupture. These complications have not simultaneously been reported in a single SCM case. The importance of early diagnosis of serial complications of SCM and using mechanical circulatory support as a treatment strategy are highlighted. Read More

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http://dx.doi.org/10.1016/j.cjca.2018.12.005DOI Listing
February 2019
2 Reads

Contrary to Expectations: Off-Label Transcatheter Aortic Valve Replacement in the Case of Left Ventricular Outflow Tract Obstruction.

Can J Cardiol 2019 Feb 12;35(2):229.e5-229.e6. Epub 2018 Dec 12.

Division of Cardiology, Pulmonology, and Vascular Medicine, Medical Faculty, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany.

We present the case of a 71-year-old woman who showed recurrent signs of congestive heart failure with the need of rehospitalization after double valve (mitral and aortic) replacement. Extensive diagnostic workup revealed a moderate aortic stenosis and additionally a significant left ventricular outflow tract obstruction. The tissue overgrowth might be attributed to an inflammatory reaction with extensive pannus deposit after aortic valve surgery. Read More

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http://dx.doi.org/10.1016/j.cjca.2018.12.007DOI Listing
February 2019
2 Reads

Traumatic Pulmonary Hypertension Secondary to Arteriovenous Fistula and Remote Gunshot Wound.

Can J Cardiol 2019 Feb 8;35(2):229.e11-229.e13. Epub 2018 Dec 8.

Division of Respiratory and Sleep Medicine, Departments of Medicine and Critical Care Medicine, Kingston Health Sciences Centre, Queen's University, Kingston, Ontario, Canada.

Pulmonary hypertension is a known complication of high-flow arteriovenous fistulas (AVFs). We present a case of a 58-year-old man who sustained a gunshot wound 6.5 years before presentation for worsening pulmonary hypertension (PH). Read More

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http://dx.doi.org/10.1016/j.cjca.2018.12.003DOI Listing
February 2019
2 Reads

Marijuana Lollipop-Induced Myocardial Infarction.

Can J Cardiol 2019 Feb;35(2):229.e1-229.e3

Horizon Health Department of Cardiology, Saint John, New Brunswick, Canada. Electronic address:

A 70-year-old man with known coronary artery disease presented with crushing chest pain, diaphoresis, and pallor after consuming a marijuana lollipop; the pain began within 30 minutes of consumption. His troponin T increased from 94 ng/L to 216 ng/L, with slight ST changes but no gross ST elevations. Discharge diagnosis was non-ST-elevation myocardial infarction, and subsequent nuclear medicine wall motion studies showed worsening ejection fraction (40% to 31%). Read More

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http://dx.doi.org/10.1016/j.cjca.2018.11.033DOI Listing
February 2019
1 Read

Minimally Invasive Surgical Aortic Valve Replacement: An Overview of Recent Advances.

Can J Cardiol 2019 Feb 4;35(2):225-228. Epub 2018 Dec 4.

Section of Cardiac Surgery, Division of Cardiac Sciences, Libin Cardiovascular Institute of Alberta, University of Calgary, Calgary, Alberta, Canada. Electronic address:

Aortic valve replacement (AVR) is the only definitive treatment for severe aortic stenosis. Options for valve replacement include surgical AVR (SAVR) and percutaneous transcatheter AVR. Although transcatheter AVR has recently been shown to be the optimal approach for high-risk patients, SAVR is the gold standard for patients with low and intermediate surgical risk. Read More

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http://dx.doi.org/10.1016/j.cjca.2018.11.027DOI Listing
February 2019
2 Reads

What the Cardiologist Should Know About Mitochondrial Cardiomyopathy?

Can J Cardiol 2019 Feb 29;35(2):221-224. Epub 2018 Nov 29.

Department of Cardiology, Institut universitaire de cardiologie et de pneumologie de Québec, Laval University, Quebec City, Quebec, Canada. Electronic address:

Mitochondrial diseases are a heterogeneous group of rare hereditary disorders that may manifest with single organ involvement or as multisystemic disease. The pathophysiology of mitochondrial disease is complex and related to mutations of genes encoding mitochondrial proteins that are crucial to the cellular respiratory chain. Given its almost exclusive aerobic metabolism, the heart is particularly susceptible to mitochondrial dysfunction and commonly involved in mitochondrial disorders. Read More

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http://dx.doi.org/10.1016/j.cjca.2018.11.018DOI Listing
February 2019
2 Reads

Fontan-Associated Liver Disease: Evidence for Early Surveillance of Liver Health in Pediatric Fontan Patients.

Can J Cardiol 2019 Feb 29;35(2):217-220. Epub 2018 Nov 29.

Division of Cardiology, Department of Pediatrics, British Columbia Children's Hospital and University of British Columbia, Vancouver, British Columbia, Canada. Electronic address:

The growing awareness of Fontan-associated liver disease (FALD) in adults with Fontan physiology has provided the impetus to better understand the natural history of FALD and develop a reliable noninvasive method to diagnose and monitor liver health in this population. Biochemical and imaging tests have been investigated to determine their association with liver pathology. The congestive hepatopathy that develops after the Fontan procedure has made interpreting these tests challenging. Read More

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http://dx.doi.org/10.1016/j.cjca.2018.11.019DOI Listing
February 2019
1 Read

MD1 Deficiency Promotes Inflammatory Atrial Remodelling Induced by High-Fat Diets.

Can J Cardiol 2019 Feb 29;35(2):208-216. Epub 2018 Nov 29.

Department of Cardiology, Renmin Hospital of Wuhan University, Cardiovascular Research Institute of Wuhan University, and Hubei Key Laboratory of Cardiology, Hubei, China. Electronic address:

Background: Myeloid differentiation protein 1 (MD1) is expressed in various tissues, including the heart. However, the role of MD1 in obesity-related atrial remodelling remains incompletely understood. Here, this study intends to determine the regulatory role and underlying mechanisms of MD1 in obesity-related atrial remodelling. Read More

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http://dx.doi.org/10.1016/j.cjca.2018.11.020DOI Listing
February 2019
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Impact of Discharge Location After Transcatheter Aortic Valve Replacement on 1-Year Outcomes in Women: Results From the WIN-TAVI Registry.

Can J Cardiol 2019 Feb 12;35(2):199-207. Epub 2018 Dec 12.

Icahn School of Medicine at Mount Sinai, New York, New York, USA. Electronic address:

Background: Several clinical and procedural factors determine outcomes after transcatheter aortic valve replacement (TAVR), but data are scarce on the impact of post-TAVR discharge disposition on long-term outcomes. We sought to analyse whether discharge location after TAVR is associated with 1-year outcomes in women undergoing contemporary TAVR.

Methods: The Women's INternational Transcatheter Aortic Valve Implantation (WIN-TAVI) registry is the first all-female TAVR registry to study the safety and performance of contemporary TAVR in women (n = 1019). Read More

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http://dx.doi.org/10.1016/j.cjca.2018.11.035DOI Listing
February 2019
1 Read

Shortening Hospital Stay Is Feasible and Safe in Patients With Chronic Thromboembolic Pulmonary Hypertension Treated With Balloon Pulmonary Angioplasty.

Can J Cardiol 2019 Feb 7;35(2):193-198. Epub 2018 Dec 7.

Department of Cardiology, Keio University School of Medicine, Tokyo, Japan.

Background: There is no consensus on the length of hospital stay (LOHS) and post-interventional management after balloon pulmonary angioplasty (BPA) in patients with chronic thromboembolic pulmonary hypertension (CTEPH). We examined temporal trends with respect to LOHS and requirement for intensive care for BPA and their relationship with the incidence of BPA-related complications.

Methods: From November 2012 to September 2017, a total of 123 consecutive patients with CTEPH who underwent BPA were enrolled (age: 66. Read More

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http://dx.doi.org/10.1016/j.cjca.2018.12.001DOI Listing
February 2019

Clinical Utility of Pre-Exercise Stress Testing in People With Diabetes.

Can J Cardiol 2019 Feb 20;35(2):185-192. Epub 2018 Nov 20.

Department of Medicine, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada; Department of Community Health Sciences, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada; Department of Cardiac Sciences, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada; O'Brien Institute for Public Health, University of Calgary, Calgary, Alberta, Canada; Faculty of Kinesiology, University of Calgary, Calgary, Alberta, Canada.

Background: Although suggested by practice guidelines, the need for pre-exercise stress testing in asymptomatic people with diabetes remains controversial. We examined the utility of screening with pre-exercise stress testing in patients with diabetes.

Methods: We completed a cohort study, evaluating patients with diabetes who attended an exercise program intake session between 2007 and 2012. Read More

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http://dx.doi.org/10.1016/j.cjca.2018.11.007DOI Listing
February 2019
1 Read

Variability in the Echocardiographic Evaluation of the Systemic Right Ventricle.

Can J Cardiol 2019 Feb 30;35(2):178-184. Epub 2018 Nov 30.

Adult Congenital Heart Center, Montreal Heart Institute, Université de Montréal, Montreal, Quebec, Canada. Electronic address:

Background: Echocardiographic evaluation of the systemic right ventricle (sRV) remains challenging in patients with transposition of the great arteries (TGA) corrected by an atrial switch (AS) and with congenitally corrected TGA (ccTGA). The aim of this study was to determine the interobserver and intraobserver variability of echocardiographic parameters for sRV size and systolic function.

Methods: Six independent observers retrospectively interpreted 44 previously acquired echocardiograms (25 patients with TGA/AS and 19 patients with ccTGA). Read More

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http://dx.doi.org/10.1016/j.cjca.2018.11.021DOI Listing
February 2019
2 Reads

Health Care Utilization After Ventricular Tachycardia Ablation: A Propensity Score-Matched Cohort Study.

Can J Cardiol 2019 Feb 25;35(2):169-177. Epub 2018 Oct 25.

University Health Network, Toronto General Hospital, University of Toronto, Toronto, Ontario, Canada. Electronic address:

Background: Catheter ablation of ventricular tachycardia (VT) can reduce the burden of ventricular arrhythmia (VA) but its effect on health care utilization and costs after such therapy is poorly known. We sought to compare the rates of cardiovascular (CV)-related hospitalizations, survival, and health care costs in patients with recurrent VT treated either with VT ablation or with medical therapy.

Methods: One-hundred implantable cardioverter-defibrillator patients with structural heart disease who underwent VT ablation were included. Read More

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http://dx.doi.org/10.1016/j.cjca.2018.10.011DOI Listing
February 2019
1 Read

Association Between Patient and Physician Sex and Physician-Estimated Stroke and Bleeding Risks in Atrial Fibrillation.

Can J Cardiol 2019 Feb 3;35(2):160-168. Epub 2018 Dec 3.

Terrence Donnelly Heart Centre, St Michael's Hospital, University of Toronto, Toronto, Ontario, Canada; Canadian Heart Research Centre, Toronto, Ontario, Canada. Electronic address:

Background: Physicians treating nonvalvular atrial fibrillation (AF) assess stroke and bleeding risks when deciding on anticoagulation. The agreement between empirical and physician-estimated risks is unclear. Furthermore, the association between patient and physician sex and anticoagulation decision-making is uncertain. Read More

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http://dx.doi.org/10.1016/j.cjca.2018.11.023DOI Listing
February 2019
1 Read

Cardioprotective Effect of Statins in Patients With HER2-Positive Breast Cancer Receiving Trastuzumab Therapy.

Can J Cardiol 2019 Feb 4;35(2):153-159. Epub 2018 Dec 4.

Division of Cardiology, Peter Munk Cardiac Center, Ted Rogers Program in Cardiotoxicity Prevention, Toronto General Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada. Electronic address:

Background: Statins can reduce the risk of anthracycline-induced cardiotoxicity. Whether such cardioprotective effects can be seen in trastuzumab-treated patients has not been explored.

Methods: Consecutive women with HER2+ breast cancer who received trastuzumab with or without anthracyclines were identified retrospectively. Read More

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http://dx.doi.org/10.1016/j.cjca.2018.11.028DOI Listing
February 2019
1 Read

Pre-exercise Stress Testing in Type 2 Diabetes: Another Case of Choosing Wisely?

Can J Cardiol 2019 Feb 11;35(2):150-152. Epub 2018 Dec 11.

Department of Medicine, Division of Cardiology, St Michael's Hospital, University of Toronto, Toronto, Ontario, Canada; Keenan Research Centre for Biomedical Science, St Michael's Hospital, Toronto, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.cjca.2018.12.008DOI Listing
February 2019

Health Economic Analysis of Catheter Ablation for Ventricular Tachycardia: Breaking Even With Medical Therapy?

Can J Cardiol 2019 Feb 12;35(2):147-149. Epub 2018 Dec 12.

Arrhythmia Service, Division of Cardiology, Department of Medicine, University of Ottawa Heart Institute, Ottawa, Ontario, Canada.

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http://dx.doi.org/10.1016/j.cjca.2018.12.012DOI Listing
February 2019
1 Read

Physician Estimation of Thrombotic and Bleeding Risks in Atrial Fibrillation: Let's Talk About Sex.

Can J Cardiol 2019 Feb 12;35(2):145-146. Epub 2018 Dec 12.

Liverpool Centre for Cardiovascular Science, University of Liverpool and Liverpool Heart & Chest Hospital, Liverpool, United Kingdom; Aalborg Thrombosis Research Unit, Department of Clinical Medicine, Aalborg University, Aalborg, Denmark. Electronic address:

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http://dx.doi.org/10.1016/j.cjca.2018.12.011DOI Listing
February 2019
1 Read

Managing Cannabis Use in Patients With Cardiovascular Disease.

Authors:
Neal L Benowitz

Can J Cardiol 2019 Feb 29;35(2):138-141. Epub 2018 Dec 29.

Division of Clinical Pharmacology and Experimental Therapeutics, Medical Service, Departments of Medicine, and Biopharmaceutical Sciences; Center for Tobacco Control Research and Education, University of California, San Francisco, California, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cjca.2018.12.033DOI Listing
February 2019
1 Read

The Canadian Journal of Cardiology: Open and Growing.

Authors:
Stanley Nattel

Can J Cardiol 2019 Feb 3;35(2):133-137. Epub 2019 Jan 3.

From the Department of Medicine, Montréal Heart Institute and Université de Montréal, and Department of Pharmacology and Therapeutics, McGill University, Montréal, Québec, Canada; IHU Liryc and Fondation Bordeaux Université, Bordeaux, France; and Institute of Pharmacology, West German Heart and Vascular Center, Faculty of Medicine, University Duisburg-Essen, Essen, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.cjca.2018.12.037DOI Listing
February 2019
1 Read

2019 Canadian Cardiovascular Society/Canadian Association of Interventional Cardiology Guidelines on the Acute Management of ST-Elevation Myocardial Infarction: Focused Update on Regionalization and Reperfusion.

Can J Cardiol 2019 Feb;35(2):107-132

Southlake Regional Health Centre, University of Toronto, Toronto, Ontario, Canada. Electronic address:

Rapid reperfusion of the infarct-related artery is the cornerstone of therapy for the management of acute ST-elevation myocardial infarction (STEMI). Canada's geography presents unique challenges for timely delivery of reperfusion therapy for STEMI patients. The Canadian Cardiovascular Society/Canadian Association of Interventional Cardiology STEMI guideline was developed to provide advice regarding the optimal acute management of STEMI patients irrespective of where they are initially identified: in the field, at a non-percutaneous coronary intervention-capable centre or at a percutaneous coronary intervention-capable centre. Read More

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http://dx.doi.org/10.1016/j.cjca.2018.11.031DOI Listing
February 2019
1 Read
3.711 Impact Factor

Impact of Accumulated Serum Uric Acid on Coronary Culprit Lesion Morphology Determined by Optical Coherence Tomography and Cardiac Outcomes in Patients with Acute Coronary Syndrome.

Cardiology 2019 Feb 13;141(4):190-198. Epub 2019 Feb 13.

Department of Cardiovascular Medicine, Nippon Medical School, Tokyo, Japan.

Objectives: We aimed to examine the relations of very high levels of serum uric acid (sUA) with features of culprit lesion plaque morphology determined by optical coherence tomography (OCT) and adverse clinical outcomes in patients with acute coronary syndrome (ACS).

Methods: We retrospectively compared ACS patients according to sUA levels of > 8.0 mg/dL (n = 169), 7. Read More

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http://dx.doi.org/10.1159/000496053DOI Listing
February 2019
1 Read

Very High Serum Uric Acid Levels, Plaque Morphology, and the Acute Coronary Syndrome.

Cardiology 2019 Feb 13;141(4):199-201. Epub 2019 Feb 13.

Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart, Lung, and Blood Vessel Diseases, Beijing Key Laboratory of Precision Medicine of Coronary Atherosclerotic Diseases, Clinical Center for Coronary Heart Diseases, Beijing,

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http://dx.doi.org/10.1159/000496982DOI Listing
February 2019
1 Read

Statins Work, But Only in People Who Take Them.

Authors:
Ann Marie Navar

JAMA Cardiol 2019 Feb 13. Epub 2019 Feb 13.

Duke Clinical Research Institute, Durham, North Carolina.

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http://dx.doi.org/10.1001/jamacardio.2018.4948DOI Listing
February 2019
1 Read

Association of Statin Adherence With Mortality in Patients With Atherosclerotic Cardiovascular Disease.

JAMA Cardiol 2019 Feb 13. Epub 2019 Feb 13.

Division of Cardiovascular Medicine and Cardiovascular Institute, Stanford University, Stanford, California.

Importance: Statins decrease mortality in those with atherosclerotic cardiovascular disease (ASCVD), but statin adherence remains suboptimal.

Objective: To determine the association between statin adherence and mortality in patients with ASCVD who have stable statin prescriptions.

Design, Setting, And Participants: This retrospective cohort analysis included patients who were between ages 21 and 85 years and had 1 or more International Classification of Diseases, Ninth Revision, Clinical Modification codes for ASCVD on 2 or more dates in the previous 2 years without intensity changes to their statin prescription who were treated within the Veterans Affairs Health System between January 1, 2013, and April 2014. Read More

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http://dx.doi.org/10.1001/jamacardio.2018.4936DOI Listing
February 2019

Sex and Genotype in Long QT Syndrome Risk Stratification.

Authors:
Wojciech Zareba

JAMA Cardiol 2019 Feb 13. Epub 2019 Feb 13.

Clinical Cardiovascular Research Center, Division of Cardiology, University of Rochester Medical Center, Rochester, New York.

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http://dx.doi.org/10.1001/jamacardio.2018.4947DOI Listing
February 2019

Association of Genetic and Clinical Aspects of Congenital Long QT Syndrome With Life-Threatening Arrhythmias in Japanese Patients.

JAMA Cardiol 2019 Feb 13. Epub 2019 Feb 13.

Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center, Suita, Japan.

Importance: Long QT syndrome (LQTS) is caused by several ion channel genes, yet risk of arrhythmic events is not determined solely by the responsible gene pathogenic variants. Female sex after adolescence is associated with a higher risk of arrhythmic events in individuals with congenital LQTS, but the association between sex and genotype-based risk of LQTS is still unclear.

Objective: To examine the association between sex and location of the LQTS-related pathogenic variant as it pertains to the risk of life-threatening arrhythmias. Read More

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http://cardiology.jamanetwork.com/article.aspx?doi=10.1001/j
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http://dx.doi.org/10.1001/jamacardio.2018.4925DOI Listing
February 2019
4 Reads

Modulating myosin function to treat hypertrophic cardiomyopathy.

Nat Rev Cardiol 2019 Feb 12. Epub 2019 Feb 12.

Nature Reviews Cardiology, .

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http://dx.doi.org/10.1038/s41569-019-0170-9DOI Listing
February 2019
2 Reads

Association of Survival With Femoropopliteal Artery Revascularization With Drug-Coated Devices.

JAMA Cardiol 2019 Feb 12. Epub 2019 Feb 12.

Smith Center for Outcomes Research in Cardiology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts.

Importance: In a recent meta-analysis of randomized clinical trials, femoropopliteal artery revascularization with paclitaxel drug-coated devices was associated with increased long-term all-cause mortality compared with non-drug-coated devices. However, to our knowledge, these findings have not been replicated in other data sources and may be subject to confounding from missing data associated with patient withdrawal and loss to follow-up.

Objective: To evaluate differences in all-cause mortality between patients who were treated with drug-coated devices vs non-drug-coated devices for femoropopliteal artery revascularization. Read More

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http://cardiology.jamanetwork.com/article.aspx?doi=10.1001/j
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http://dx.doi.org/10.1001/jamacardio.2019.0325DOI Listing
February 2019
6 Reads

Assessing the Long-term Safety of Endovascular Therapies-The Case of Peripheral Paclitaxel-Coated Devices.

Authors:
Jay Giri

JAMA Cardiol 2019 Feb 12. Epub 2019 Feb 12.

Cardiovascular Division, Hospital of the University of Pennsylvania, Philadelphia.

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http://dx.doi.org/10.1001/jamacardio.2019.0339DOI Listing
February 2019

Cardiac Surgery in HIV Patients: State of the Art.

Can J Cardiol 2018 Nov 20. Epub 2018 Nov 20.

Ottawa Heart Institute, University of Ottawa, Ottawa, Ontario, Canada.

The clinical status of HIV infection has changed dramatically with the introduction of combined antiretroviral therapy. Patients with HIV are now living long enough to be susceptible to chronic illnesses, such as coronary disease and nonischemic cardiomyopathy, which can be consequences of the combined antiretroviral therapy treatment itself. Cardiovascular diseases are a major source of morbidity and mortality in HIV-positive patients. Read More

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http://dx.doi.org/10.1016/j.cjca.2018.11.006DOI Listing
November 2018
2 Reads

Prognostic Value of Vasodilator Stress Cardiac Magnetic Resonance Imaging: A Multicenter Study With 48 000 Patient-Years of Follow-up.

JAMA Cardiol 2019 Feb 8. Epub 2019 Feb 8.

Duke Cardiovascular Magnetic Resonance Center, Durham, North Carolina.

Importance: Stress cardiac magnetic resonance imaging (CMR) is not widely used in current clinical practice, and its ability to predict patient mortality is unknown.

Objective: To determine whether stress CMR is associated with patient mortality.

Design, Setting, And Participants: Real-world evidence from consecutive clinically ordered CMR examinations. Read More

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http://dx.doi.org/10.1001/jamacardio.2019.0035DOI Listing
February 2019
1 Read

Mobilizing regulatory T cells to promote myocardial repair.

Authors:
Gregory B Lim

Nat Rev Cardiol 2019 Feb 6. Epub 2019 Feb 6.

Nature Reviews Cardiology, .

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http://dx.doi.org/10.1038/s41569-019-0168-3DOI Listing
February 2019
2 Reads

Analysis of the Associations between Obesity Indices and Left Ventricular Mass.

Cardiology 2019 Feb 6;141(4):183-189. Epub 2019 Feb 6.

Department of Cardiology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.

The aims of this study were to investigate the association between different obesity indices and left ventricular mass (LVM) and to develop interventions for obese hypertensive patients to delay the progression of left ventricular hypertrophy (LVH). The association between the visceral adiposity index (VAI) and LVM was explored using multiple regression analysis in all subjects (n = 1,035), the subgroups of patients aged < 65 (n = 713) and ≥65 years (n = 322), and perimenopausal women (n = 319). The VAI was the only obesity index associated with LVH (OR = 1. Read More

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http://dx.doi.org/10.1159/000496177DOI Listing
February 2019
1 Read