31,197 results match your criteria Cardiology[Journal]


Incidence, Characteristics, and Outcomes of Myocardial Infarction in Patients With Peripheral Artery Disease: Insights From the EUCLID Trial.

JAMA Cardiol 2018 Dec 12. Epub 2018 Dec 12.

Stanford Center for Clinical Research, Department of Medicine, Stanford University School of Medicine, Stanford, California.

Importance: Patients with peripheral artery disease (PAD) are at high risk for myocardial infarction (MI).

Objective: To characterize the incidence and types of MI in a PAD population, identify factors associated with MI, and determine the association of MI with cardiovascular mortality and acute limb ischemia.

Design, Setting, And Participants: The Study Comparing Cardiovascular Effects of Ticagrelor and Clopidogrel in Patients With Peripheral Artery Disease (EUCLID) was a double-blind randomized clinical trial conducted at 811 sites in 28 countries that randomized 13 885 patients with symptomatic PAD to monotherapy with ticagrelor or clopidogrel. Read More

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December 2018

Interindividual Variation in Low-Density Lipoprotein Cholesterol Level Reduction With Evolocumab: An Analysis of FOURIER Trial Data.

JAMA Cardiol 2018 Dec 12. Epub 2018 Dec 12.

Thrombolysis in Myocardial Infarction (TIMI) Study Group, Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.

Importance: Little is known about the heterogeneity in low-density lipoprotein cholesterol levels (LDL-C) lowering with proprotein convertase subtilisin kexin 9 (PCSK9) inhibitor medications.

Objective: To evaluate the interindividual variability in LDL-C reduction with the PCSK9 inhibitor drug evolocumab.

Design, Setting, And Participants: We examined the percentage change in LDL-C levels from baseline in the Further Cardiovascular Outcomes Research With PCSK9 Inhibition in Subjects With Elevated Risk (FOURIER) trial, a placebo-controlled randomized clinical trial of the PCSK9 inhibitor evolocumab in patients with stable atherosclerotic cardiovascular disease who were taking statin medications. Read More

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December 2018
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ROBO4 variants linked to congenital heart defects.

Nat Rev Cardiol 2018 Dec 7. Epub 2018 Dec 7.

Nature Reviews Cardiology, .

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December 2018

Cardiovascular calcification: artificial intelligence and big data accelerate mechanistic discovery.

Nat Rev Cardiol 2018 Dec 10. Epub 2018 Dec 10.

Center for Interdisciplinary Cardiovascular Sciences, Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

Cardiovascular calcification is a health disorder with increasing prevalence and high morbidity and mortality. The only available therapeutic options for calcific vascular and valvular heart disease are invasive transcatheter procedures or surgeries that do not fully address the wide spectrum of these conditions; therefore, an urgent need exists for medical options. Cardiovascular calcification is an active process, which provides a potential opportunity for effective therapeutic targeting. Read More

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December 2018

Efficacy of Simultaneous Kissing Stent Technique Using Two Polytetrafluoroethylene-Covered Stents for Severe Coronary Perforation Involving Bifurcation.

Can J Cardiol 2018 Dec 17;34(12):1689.e1-1689.e2. Epub 2018 Aug 17.

Department of Cardiology, Ogaki Municipal Hospital, Ogaki, Japan. Electronic address:

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December 2018

Successful Treatment of Erdheim-Chester Disease With Coronary Artery Involvement.

Can J Cardiol 2018 Dec 29;34(12):1688.e9-1688.e11. Epub 2018 Sep 29.

Department of Hematology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. Electronic address:

Erdheim-Chester disease (ECD) is a rare non-Langerhans histiocytosis and inflammatory myeloid neoplasm with poor prognosis. Symmetric long bone osteosclerosis occurs in nearly all patients, but other organs are often involved. Coronary artery involvement is rare, but was encountered in a patient who experienced angina. Read More

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December 2018

Multimodality Imaging of a Giant Right Coronary Artery Aneurysm.

Can J Cardiol 2018 Dec 24;34(12):1688.e5-1688.e7. Epub 2018 Aug 24.

Section of Cardiology, Department of Internal Medicine, University of Manitoba, Winnipeg, Manitoba, Canada. Electronic address:

We describe a case of a 54-year-old woman who had a right cardiac mass found on coronary angiography. Echocardiography, computed tomography, and cardiac magnetic resonance imaging characterized it as a thrombosed giant right coronary artery aneurysm. This was confirmed on pathology. Read More

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December 2018

MitraClip After Disinsertion of a Prosthetic Mitral Ring.

Can J Cardiol 2018 Dec 17;34(12):1688.e25-1688.e27. Epub 2018 Sep 17.

Department of Medical Specialties, Cardiology Division, University Hospitals of Geneva, Geneva, Switzerland.

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December 2018

An Unusual Case of Cardiac Tamponade Secondary to an Elevated Right Hemidiaphragm.

Can J Cardiol 2018 Dec 19;34(12):1688.e21-1688.e23. Epub 2018 Oct 19.

Northern Ontario School of Medicine, Health Sciences North, Sudbury, Ontario, Canada. Electronic address:

Diaphragmatic eventration in old age is a rare phenomenon. Typically, it is thought to originate as a result of failure of development of the muscles of the diaphragm. Less commonly, it can occur secondary to acquired conditions resulting from spinal cord or phrenic nerve injury and is only detected incidentally when the patient presents with dyspnea, chest infection, or cardiac compression symptoms. Read More

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December 2018

Sheathless Transcaval Transcatheter Aortic Valve Implantation Through an Abdominal Aortic Graft.

Can J Cardiol 2018 Dec 16;34(12):1688.e17-1688.e19. Epub 2018 Oct 16.

Department of Cardiology, Swiss Cardiovascular Center, University Hospital, Bern, Switzerland. Electronic address:

An 82-year-old patient presented with severe symptomatic aortic stenosis, a high surgical risk profile, and a history of abdominal aortic replacement. Arterial access vessel conditions precluded transarterial transcatheter aortic valve implantation (TAVI). Transcaval access through the aortic graft was achieved; however, tortuosity and resistance at the graft entry site hampered insertion of the introducer sheath and delivery system. Read More

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December 2018

First Report of an Acute, Obstructive Thrombosis of a Melody Valve Used for Transcatheter Pulmonary Replacement.

Can J Cardiol 2018 Dec 20;34(12):1688.e13-1688.e15. Epub 2018 Aug 20.

Department of Cardiology and Internal Intensive Medicine, Kepler University Hospital, Medical Faculty, Johannes Kepler University, Linz, Austria.

Transcatheter pulmonary valve (TPV) replacement is an effective therapy of right ventricular outflow tract conduit dysfunction. Acute complications after TPV implantation include infective endocarditis, stent fracture, and device dislocation. We present a novel, life-threatening complication: an acute, noninfectious TPV thrombosis. Read More

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December 2018

Intraprocedure Type II Kounis Syndrome Secondary to Radioiodine Contrast During Coronary Angiography.

Can J Cardiol 2018 Dec 24;34(12):1688.e1-1688.e3. Epub 2018 Aug 24.

Department of Cardiology, Westmead Hospital, New South Wales, Australia.

An 83-year-old man with a previous right coronary artery (RCA) stent presented to the emergency department with syncope, dynamic lateral ST depression, and a serum troponin of 6148 ng/L (< 17). Coronary angiography revealed a patent proximal RCA stent and significant left-sided disease. The procedure was complicated by inferior ST elevation, urticaria, hypotension, and acute proximal RCA occlusion. Read More

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December 2018

Coronary Vasospasm Following Heart Transplantation: Rapid Progression to Aggressive Cardiac Allograft Vasculopathy.

Can J Cardiol 2018 Dec 20;34(12):1687.e9-1687.e11. Epub 2018 Aug 20.

Division of Cardiology, University of British Columbia, Vancouver, British Columbia, Canada. Electronic address:

Coronary artery vasospasm (CVS) has been described in orthotopic heart transplant patients but is rare in the post-transplanted, denervated heart. Severe CVS has been associated with accelerated cardiac allograft vasculopathy (CAV) and allograft rejection. Allograft vasculopathy is the leading cause of decreased long-term survival in orthotopic heart transplant. Read More

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December 2018

Diffuse Subepicardial Late Gadolinium Enhancement After Heart Transplant: A Potentially Ominous Finding.

Can J Cardiol 2018 Dec 24;34(12):1687.e3-1687.e7. Epub 2018 Aug 24.

Division of Cardiology, University of Ottawa Heart Institute, Ottawa, Ontario, Canada. Electronic address:

Late gadolinium enhancement (LGE) on cardiac magnetic resonance imaging has prognostic utility in populations with cardiac disease, including heart transplant (HT) recipients. The etiology of specific LGE patterns and their correlation with outcomes after HT are unclear. Antibody-mediated rejection and cardiac allograft vasculopathy are major causes of death, and their evaluation remains challenging. Read More

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December 2018

Myocardial Infarction Caused by Accelerated Plaque Formation Related to Myocardial Bridge in a Young Man.

Can J Cardiol 2018 Dec 20;34(12):1687.e13-1687.e15. Epub 2018 Aug 20.

Division of Cardiology, Yokohama City University Medical Center, Yokohama, Japan.

A 28-year-old man without coronary risk factors was admitted to the hospital with acute coronary syndromes (ACS). The angiogram and intravascular ultrasound revealed myocardial bridge (MB) in the mid-left anterior descending artery and flow-limiting plaque located 15.4 mm proximal to MB. Read More

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December 2018

Double-Valve Surgery After Cardiac Retransplantation.

Can J Cardiol 2018 Dec 29;34(12):1687.e1-1687.e2. Epub 2018 Sep 29.

Division of Cardiac Surgery, University of Ottawa Heart Institute, Ottawa, Ontario, Canada. Electronic address:

We provide an update on Canada's first neonatal heart transplant recipient who, after cardiac retransplantation, underwent a mitral valve replacement and tricuspid valve repair. Twenty-seven years after his initial heart surgery and 13 years after his most recent transplant, this patient developed heart failure with severe mitral regurgitation secondary to a calcified mitral valve. The patient was highly sensitized with no evidence of allograft rejection; therefore, mitral and tricuspid surgery was performed. Read More

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December 2018

Performing Cardiac Magnetic Resonance Imaging in Patients With Cardiac Implantable Electronic Devices: A Contemporary Review.

Can J Cardiol 2018 Dec 29;34(12):1682-1686. Epub 2018 Sep 29.

Azrieli Heart Centre, Division of Cardiology, Jewish General Hospital, McGill University, Montreal, Quebec, Canada; Centre for Clinical Epidemiology, Lady Davis Institute, Jewish General Hospital, Montreal, Quebec, Canada.

There are expanding indications for cardiac magnetic resonance imaging (CMR) in patients with cardiac implantable electronic devices (CIEDs). The presence of a CIED had been regarded as a contraindication to CMR due to concerns of arrhythmias, significant changes to lead parameters, and detrimental changes to device programming. The risk of these potential adverse events is theoretically higher in patients undergoing CMR as compared with other anatomic sites. Read More

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December 2018

A Population-Based Study of Adherence to Guideline Recommendations and Appropriate-Use Criteria for Implantable Cardioverter Defibrillators.

Can J Cardiol 2018 Dec 24;34(12):1677-1681. Epub 2018 Aug 24.

Mazankowski Alberta Heart Institute, University of Alberta, Division of Cardiology, Edmonton, Alberta, Canada. Electronic address:

Studies evaluating physician adherence to guideline recommendations for implantable cardioverter defibrillator (ICD) therapy are sparse, and none exist for the application of appropriate-use criteria (AUC) in clinical practice. As part of a quality improvement initiative, a review of all ICD procedures was performed from January 1, 2015 to December 31, 2016 in Alberta, Canada, to evaluate the proportion of patients receiving appropriate ICD therapy and to identify reasons for nonadherence. Our device-implant process involves an electrophysiologist or implanting cardiologist evaluation, reminders of ICD eligibility criteria on the device requisition, and peer-review consensus. Read More

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December 2018

Improving Quality of Congenital Heart Disease Research in Canada: Standardizing Nomenclature Across Canada.

Can J Cardiol 2018 Dec 29;34(12):1674-1676. Epub 2018 Aug 29.

Department of Pediatrics, Université de Sherbrooke, and Centre de recherche du centre hospitalier universitaire de Sherbrooke, Sherbrooke, Quebec, Canada. Electronic address:

In an effort to improve the quality of interinstitutional and nation-wide research into congenital heart disease (CHD) in Canada, the authors propose the national implementation of a single nomenclature list for CHD as a first step towards achieving a common disease classification system in all Canadian institutions that deal with congenital heart malformations. The authors offer a brief overview of the history and state of nomenclature for CHD in Canada and recommend the national use of the CHD diagnostic list that was recently finalized by the International Society for Nomenclature of Paediatric and Congenital Heart Disease. This list was submitted to the World Health Organization for incorporation into the 11th iteration of the International Classification of Diseases and was recently translated into French by members of the International Society for Nomenclature of Paediatric and Congenital Heart Disease. Read More

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December 2018

Poor Adherence to Dietary Guidelines Among French-Speaking Adults in the Province of Quebec, Canada: The PREDISE Study.

Can J Cardiol 2018 Dec;34(12):1665-1673

Institute of Nutrition and Functional Foods, Université Laval, Quebec, Canada; School of Nutrition, Université Laval, Quebec, Canada. Electronic address:

Background: Regular monitoring of the population's food and nutrient intake is essential to develop effective nutrition-focused public health policies. The aim of this study was to provide dietary intake estimates using an age- and sex-representative sample of French-speaking adults with Internet access from 5 administrative regions in the province of Quebec, Canada.

Methods: PRÉDicteurs Individuels, Sociaux et Environnementaux (PREDISE) is a multicentre cross-sectional study that used a Web-based approach to collect individual, social, and environmental data on factors associated with adherence to dietary recommendations. Read More

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December 2018

A Clinical Risk Scoring Tool to Predict Readmission After Cardiac Surgery: An Ontario Administrative and Clinical Population Database Study.

Can J Cardiol 2018 Dec 22;34(12):1655-1664. Epub 2018 Sep 22.

Division of Cardiac Surgery, Schulich Heart Centre, Department of Surgery, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada; Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, Ontario, Canada. Electronic address:

Background: Reducing readmission after cardiac surgery remains a quality improvement priority yet most readmission risk models examine only coronary artery bypass grafting (CABG). Our objective was to develop a predictive risk score for readmission after discharge in cardiac surgery.

Methods: All adults > 18 years undergoing isolated CABG, isolated/multiple valve, or combined CABG/valve surgery from 2008 to 2016 in Ontario were eligible. Read More

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December 2018

The Value of Claims-Based Nontraditional Risk Factors in Predicting Long-term Mortality After MitraClip Procedure.

Can J Cardiol 2018 Dec 13;34(12):1648-1654. Epub 2018 Oct 13.

Richard A. and Susan F. Smith Center for Outcomes Research in Cardiology, Beth Israel Deaconess Medical Center. Electronic address:

Background: We sought to identify nontraditional risk factors coded in administrative claims data and evaluate their ability to improve prediction of long-term mortality in patients undergoing percutaneous mitral valve repair.

Methods: Patients undergoing transcatheter mitral valve repair using MitraClip implantation between September 28, 2010, and September 30, 2015 were identified among Medicare fee-for-service beneficiaries. We used nested Cox regression models to identify claims codes predictive of long-term mortality. Read More

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December 2018

Hypotensive Effect of Heated Water-Based Exercise Persists After 12-Week Cessation of Training in Patients With Resistant Hypertension.

Can J Cardiol 2018 Dec 5;34(12):1641-1647. Epub 2018 Oct 5.

Heart Institute, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.

Background: Heated water-based exercise (HEx) promotes a marked reduction of blood pressure (BP), but it is not entirely clear whether its effects on BP persist after cessation of HEx.

Methods: We analyzed the effects of cessation of HEx on 24-hour ambulatory BP monitoring (ABPM) in patients with resistant hypertension (RH). Thirty-two patients (aged 53 ± 6 years) with RH (4 to 6 antihypertensive drugs) were randomly assigned to HEx (n = 16) or control (n = 16) groups. Read More

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December 2018

The Association of Kidney Function and Albuminuria With the Risk and Outcomes of Syncope: A Population-Based Cohort Study.

Can J Cardiol 2018 Dec 28;34(12):1631-1640. Epub 2018 Aug 28.

Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada; Division of Nephrology, Western University, London, Ontario, Canada; Ottawa Hospital Research Institute, Ottawa, Ontario, Canada. Electronic address:

Background: The risks and subsequent outcomes of syncope among seniors with chronic kidney disease (CKD) are unclear.

Methods: We conducted a population-based retrospective cohort study of 272,146 patients ≥ 66 years old, in Ontario, Canada, from April 1, 2006, to March 31, 2016. Using administrative health care databases, we examined the association of estimated glomerular filtration rate (eGFR) and urine albumin to creatinine ratio (ACR) with incident syncope and the association of incident syncope with the composite outcome of myocardial infarction, stroke, and death by levels of eGFR/ACR, using adjusted Cox proportional hazards models. Read More

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December 2018

Patterns of Incidence Rates of Cardiac Complications in Patients With Congenital Heart Disease.

Can J Cardiol 2018 Dec 29;34(12):1624-1630. Epub 2018 Sep 29.

Department of Cardiology, University Hospital of Basel, University of Basel, Basel, Switzerland. Electronic address:

Background: This study aimed to evaluate age at the first onset of cardiac complications and variation of frequency of complications between different congenital heart defects.

Methods: The analysis included participants of the Swiss Adult Congenital Heart Disease Registry (SACHER). For this study, cardiac complications up to the time of inclusion in SACHER were analysed. Read More

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December 2018
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Carotid Intima-Media Thickness in Children and Adolescents With Congenital Heart Disease.

Can J Cardiol 2018 Dec 5;34(12):1618-1623. Epub 2018 Oct 5.

Department of Paediatric Cardiology and Congenital Heart Disease, German Heart Centre Munich, Technical University Munich, Munich, Germany; Institute of Preventive Pediatrics, Technical University Munich, Munich, Germany.

Background: With increased long-term survival, children with congenital heart disease (CHD) are at increased risk of early-onset adult cardiovascular disease. Carotid intima-media thickness (cIMT) is a surrogate marker of atherosclerosis. The aim of this present study was to detect high-risk diagnostic subgroups by measuring cIMT and determine its correlates in children with CHD and subgroups of CHD compared with healthy controls. Read More

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December 2018

Accuracy of the Global Registry of Acute Coronary Events (GRACE) Risk Score in Contemporary Treatment of Patients With Acute Coronary Syndrome.

Can J Cardiol 2018 Dec 12;34(12):1613-1617. Epub 2018 Oct 12.

Cardiology Department, Meir Medical Center, Kfar Saba, Israel; Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel. Electronic address:

Background: Global Registry of Acute Coronary Events (GRACE) score has been routinely used for risk stratification in acute coronary syndromes (ACS). We aimed to investigate whether the GRACE score has remained relevant with contemporary treatment of patients with ACS.

Methods: Included were patients with ACS in the Acute Coronary Syndrome Israeli Survey (ACSIS). Read More

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December 2018

Effect of Clopidogrel vs Ticagrelor on Platelet Aggregation and Inflammation Markers After Percutaneous Coronary Intervention for ST-Elevation Myocardial Infarction.

Can J Cardiol 2018 Dec 20;34(12):1606-1612. Epub 2018 Aug 20.

Department of Cardiology, Key Laboratories of Education Ministry for Myocardial Ischemia Mechanism and Treatment, The 2nd Affiliated Hospital of Harbin Medical University, Harbin, China.

Background: Patients with acute coronary syndrome show an inflammatory response that is known to affect platelet aggregation. We aimed to clarify the relationship between the inflammation severity and the effect of antiplatelet therapy after percutaneous coronary intervention (PCI) for ST-elevation myocardial infarction (STEMI).

Methods: This retrospective, single-center study included 203 patients with STEMI who underwent primary PCI and were stratified on the basis of the antiplatelet therapy on admission (clopidogrel vs ticagrelor). Read More

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December 2018
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Cardiovascular Efficacy and Safety of PCSK9 Inhibitors: Systematic Review and Meta-analysis Including the ODYSSEY OUTCOMES Trial.

Can J Cardiol 2018 Dec;34(12):1600-1605

Division of Cardiology, Faculty of Medicine and Dentistry, University of Alberta, Alberta, Canada. Electronic address:

Proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors are efficacious lipid-lowering agents, but more precise estimates of their effects on major adverse cardiovascular events (MACE), mortality, and safety are needed. We systematically reviewed and meta-analyzed randomized controlled trials with durations ≥ 6 months comparing MACE, mortality, and safety with PCSK9 inhibitors vs control. We searched CENTRAL, Embase, MedLine and the grey literature to November 7, 2018. Read More

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December 2018

The Effect of Cardiac Rehabilitation Attendance on Sexual Activity Outcomes in Cardiovascular Disease Patients: A Systematic Review.

Can J Cardiol 2018 Dec;34(12):1590-1599

Department of Community Health Sciences, University of Calgary, Calgary, Alberta, Canada; Department of Medicine, University of Calgary, Calgary, Alberta, Canada. Electronic address:

Background: Decreased sexual activity (SA) is a common problem in patients with cardiovascular disease (CVD). Although there is evidence that cardiac rehabilitation (CR) is effective in improving physical outcomes and overall quality of life, its effects on SA remain unclear. In this systematic review we assessed the association between CR attendance and SA outcomes in adults with CVD. Read More

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December 2018

Deferred vs Immediate Stenting in Primary Percutaneous Coronary Intervention: A Collaborative Meta-analysis of Randomized Trials With Cardiac Magnetic Resonance Imaging Data.

Can J Cardiol 2018 Dec 7;34(12):1573-1580. Epub 2018 Aug 7.

Deutsches Herzzentrum München, Technische Universität München, Munich, Germany.

Background: The role of deferred vs immediate stenting during primary percutaneous coronary intervention (PCI) for patients with ST-segment elevation myocardial infarction (STEMI) remains controversial.

Methods: We undertook a collaborative meta-analysis of study-level data by searching electronic scientific databases for investigations of primary PCI patients randomized to deferred or immediate stenting and subsequent cardiac magnetic resonance imaging. Primary angiographic and imaging outcomes were slow/no-reflow and microvascular obstruction (MVO), respectively. Read More

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December 2018
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Challenges With Severe Coronary Artery Calcification in Percutaneous Coronary Intervention: A Narrative Review of Therapeutic Options.

Can J Cardiol 2018 Dec 14;34(12):1564-1572. Epub 2018 Aug 14.

Division of Cardiology, Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Alberta, Canada. Electronic address:

Coronary calcification often complicates atherosclerosis. With an aging population, coinciding with lower thresholds for coronary angiography and percutaneous coronary intervention (PCI), severe calcific coronary stenoses remain a challenge for interventional cardiologists. Although advances in coronary guidewires, percutaneous balloons, and adjunctive procedural devices have improved success of PCI, recalcitrant calcified lesions not amenable to the conventional technique frequently occur. Read More

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December 2018

Canadian Cardiovascular Society Position Statement on Familial Hypercholesterolemia: Update 2018.

Can J Cardiol 2018 Dec;34(12):1553-1563

Research Institute of the McGill University Health Centre, Royal Victoria Hospital, Montréal, Quebec, Canada; Department of Medicine, McGill University, Montréal, Quebec, Canada.

Familial hypercholesterolemia (FH) is the most common monogenic disorder causing premature atherosclerotic cardiovascular disease. It affects 1 in 250 individuals worldwide, and of the approximately 145,000 Canadians estimated to have FH, most are undiagnosed. Herein, we provide an update of the 2014 Canadian Cardiovascular Society position statement on FH addressing the need for case identification, prompt recognition, and treatment with statins and ezetimibe, and cascade family screening. Read More

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December 2018
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Food for Thought: A "Low-Tech" Road to Improved Primary Cardiovascular Prevention: Adherence to Dietary Guidelines.

Authors:
James M Brophy

Can J Cardiol 2018 Dec 4;34(12):1551-1552. Epub 2018 Oct 4.

McGill University Health Center, Centre for Health Outcomes Research, Montreal, Quebec, Canada. Electronic address:

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December 2018

Limiting Readmissions Following Cardiac Surgery-A "Common Sense" Solution.

Authors:
Harold L Lazar

Can J Cardiol 2018 Dec 28;34(12):1549-1550. Epub 2018 Sep 28.

Division of Cardiac Surgery, Boston University School of Medicine, Boston, Massachusetts, USA. Electronic address:

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December 2018

Sexual Counselling in Cardiac Rehabilitation: An Urgent Need for More Consideration and Study.

Can J Cardiol 2018 Dec;34(12):1546-1548

Cognitive Behavior Therapy Graduate Program, Salgado de Oliveira University, Niterói, Brazil.

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December 2018

The Day When Coronary Stents Ruined Everything.

Can J Cardiol 2018 Dec 9;34(12):1541-1542. Epub 2018 Nov 9.

Montréal Heart Institute, Montréal, Québec, Canada; Université de Montréal, Montréal, Québec, Canada. Electronic address:

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December 2018

Benefits of renal denervation in HFrEF.

Authors:
Gregory B Lim

Nat Rev Cardiol 2018 Dec 5. Epub 2018 Dec 5.

Nature Reviews Cardiology, .

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December 2018

Nanotherapy for abdominal aortic aneurysm.

Authors:
Gregory B Lim

Nat Rev Cardiol 2018 Dec 5. Epub 2018 Dec 5.

Nature Reviews Cardiology, .

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December 2018

Mid-term outcomes with CoreValve versus surgery.

Authors:
Gregory B Lim

Nat Rev Cardiol 2018 Dec 5. Epub 2018 Dec 5.

Nature Reviews Cardiology, .

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December 2018

Predictors of stent thrombosis and their implications for clinical practice.

Nat Rev Cardiol 2018 Dec 5. Epub 2018 Dec 5.

Kardiologie I, Zentrum für Kardiologie, University Medical Center Mainz and DZHK Standort Rhein-Main, Mainz, Germany.

Stent thrombosis (ST) is a rare but severe complication of coronary procedures with high mortality, high relapse rate and a very complex pathophysiology. An individual's susceptibility to ST is multifactorial and results from interactions between clinical factors, endothelial biology, hypersensitivity and/or inflammatory reactions, blood rheology, platelet reactivity, clotting factors, physical and mechanical properties of the stent and from the effects of these different factors on the fluid dynamics of blood flow. Since the introduction of stents 32 years ago, continuous improvements in our understanding of the pathophysiology of ST have triggered important advances, including new therapies, new technologies and an increased awareness of the implications of implantation techniques. Read More

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December 2018

Imaging of Myocardial Fibrosis and Its Functional Correlates in Aortic Stenosis: A Review and Clinical Potential.

Cardiology 2018 Dec 5;141(3):141-149. Epub 2018 Dec 5.

Cardiovascular Center Aalst, OLV Clinic, Aalst,

Patients with severe aortic stenosis (AS) show progressive fibrotic changes in the myocardium, which may impair cardiac function and patient outcomes even after successful aortic valve replacement. Detection of patients who need an early operation remains a diagnostic challenge as myocardial functional changes may be subtle. In recent years, speckle tracking echocardiography (STE) and cardiac magnetic resonance mapping have been shown to provide complementary information for the assessment of left ventricular mechanics and identification of subtle damage by focal or diffuse myocardial fibrosis, respectively. Read More

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December 2018
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National Trends and Procedural Complications from Endomyocardial Biopsy: Results from the National Inpatient Sample, 2007-2014.

Cardiology 2018 Dec 5;141(3):125-131. Epub 2018 Dec 5.

Department of Cardiovascular Medicine, University of Kansas Medical Center, Kansas City, Kansas,

Aim: The aim of this study is to report recent trends in the performance of endomyocardial biopsy (EMB) and its in-hospital complications (and their predictors) in the United States (US).

Method: We analyzed Nationwide Inpatient Sample (NIS) database from years 2007 through 2014 to identify patients who underwent EMB. Once identified, the patients were subdivided into those with no history of heart transplant (HT) (cohort 1) and those with history of HT (cohort 2). Read More

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December 2018
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Transcatheter Aortic Valve Replacement for Pure Native Aortic Valve Regurgitation: A Systematic Review.

Cardiology 2018 Dec 5;141(3):132-140. Epub 2018 Dec 5.

Department of Cardiology, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou,

Background: Transcatheter aortic valve replacement (TAVR) is a recent and an effective treatment option for high- or extreme-surgical-risk patients with symptomatic severe aortic stenosis. However, pure severe native aortic valve regurgitation (NAVR) without aortic stenosis remains a contraindication to TAVR. The aim of our systemic review analysis was to evaluate TAVR in patients with pure NAVR. Read More

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December 2018
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Has a New Determinant of Transcatheter Aortic Valve Replacement Outcomes Been Identified?

Authors:
John D Carroll

JAMA Cardiol 2018 Dec 5. Epub 2018 Dec 5.

Division of Cardiology, Department of Medicine, University of Colorado School of Medicine, Aurora.

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December 2018
1 Read

Durability Data for Bioprosthetic Surgical Aortic Valve: A Systematic Review.

JAMA Cardiol 2018 Dec 5. Epub 2018 Dec 5.

Department of Cardiovascular Medicine, Heart and Vascular Institute, Cleveland Clinic, Cleveland, Ohio.

Importance: Although several studies have reported data on surgical aortic valve durability, variability in study methodologies and definitions as well as inadequate follow-up make the interpretation of data from these studies difficult to interpret.

Objective: To review available data on structural valve deterioration (SVD) of surgical bioprosthetic aortic valves by examining the published literature as well as data reported to the US Food and Drug Administration (FDA).

Evidence Review: A systematic review using Preferred Reporting Items for Systematic Review and Meta-Analysis reporting guidelines to obtain all available data from preexisting literature on the actuarial freedom from SVD and outcomes of SVD. Read More

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December 2018
1 Read

Association of Hospital Surgical Aortic Valve Replacement Quality With 30-Day and 1-Year Mortality After Transcatheter Aortic Valve Replacement.

JAMA Cardiol 2018 Dec 5. Epub 2018 Dec 5.

Richard A. and Susan F. Smith Center for Outcomes Research in Cardiology, Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts.

Importance: Hospital outcomes for transcatheter aortic valve replacement (TAVR) may be dependent on the quality of evaluation, personnel, and procedural and postprocedural care common to patients undergoing cardiac surgery.

Objectives: We sought to assess whether those hospitals with better patient outcomes for surgical aortic valve replacement (SAVR) subsequently achieved better TAVR outcomes after launching TAVR programs.

Design, Setting, And Participants: This national cohort included US patients 65 years and older. Read More

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December 2018
1 Read

Protective transcriptional repression by junctophilin 2 fragment.

Authors:
Gregory B Lim

Nat Rev Cardiol 2019 Jan;16(1)

Nature Reviews Cardiology, .

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January 2019