420,694 results match your criteria Cardiology


Treatment of Sleep Apnea with Positive Airway Pressure and Its Association with Diastolic Dysfunction: A Systematic Review and Meta-Analysis.

Respiration 2021 Dec 6:1-11. Epub 2021 Dec 6.

Cardiology Department, SUNY Downstate, Brooklyn, New York, USA.

Background: This meta-analysis assessed the effect of long-term (>6 weeks) noninvasive positive airway pressure (PAP) on diastolic function in patients with obstructive sleep apnea (OSA).

Methods: We searched the databases for randomized clinical trials including Ovid MEDLINE, Ovid Embase Scopus, Web of Science, Google Scholar, and EBSCO CINAHL from inception up to December 20, 2019. The search was not restricted to time, publication status, or language. Read More

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December 2021

Prenatal Diagnosis of Aortic Coarctation: Prediction Algorithm according to Gestational Age.

Fetal Diagn Ther 2021 Dec 6:1-10. Epub 2021 Dec 6.

Pediatric Cardiology Department, La Paz University Hospital, Madrid, Spain.

Objectives: The aim of the study was first to quantify the diagnostic accuracy of predictive anatomical factors of aortic coarctation (CoA) and second to design a postnatal CoA probability algorithm according to gestational age (GA) in prenatal period.

Methods: Global and according to GA diagnostic performance of cardiac anatomical variables using the ROC curve were evaluated in a retrospective cohort of fetuses with suspicion of CoA (2004-2020). A serial testing strategy to predict postnatal CoA by fetal echocardiography was designed. Read More

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December 2021

Blood and Urine Biomarkers Predicting Worsening Kidney Function in Patients with Type 2 Diabetes Post-Acute Coronary Syndrome: An Analysis from the EXAMINE Trial.

Am J Nephrol 2021 Dec 6:1-8. Epub 2021 Dec 6.

Centre D'Investigation Clinique-Plurithématique Inserm CIC-P 1433, Inserm U1116, CHRU Nancy Hopitaux de Brabois, F-CRIN INI-CRCT (Cardiovascular and Renal Clinical Trialists), Université de Lorraine, Institut Lorrain Du Coeur et des Vaisseaux Louis Mathieu, Vandoeuvre lès Nancy, France.

Introduction: Worsening kidney function (WKF) is frequent among patients with type 2 diabetes (T2D) and a recent acute coronary syndrome (ACS) and is associated with a poor prognosis. An accurate prediction of WKF is clinically important.

Aims: Using data from the Cardiovascular Outcomes Study of Alogliptin in Patients with Type 2 Diabetes and Acute Coronary Syndrome trial including patients with T2D and a recent ACS, and a large biomarker panel incorporating proteins measured both in blood and urine, we aim to determine those with best performance for WKF prediction. Read More

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December 2021

MicroRNAs and exosomes: Cardiac stem cells in heart diseases.

Pathol Res Pract 2021 Nov 20;229:153701. Epub 2021 Nov 20.

Anatomical Sciences Research Center, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, Iran. Electronic address:

Treating cardiovascular diseases with cardiac stem cells (CSCs) is a valid treatment among various stem cell-based therapies. With supplying the physiological need for cardiovascular cells as their main function, under pathological circumstances, CSCs can also reproduce the myocardial cells. Although studies have identified many of CSCs' functions, our knowledge of molecular pathways that regulate these functions is not complete enough. Read More

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November 2021

Clinical correlations to distinguish severe from milder forms of obstructive sleep apnoea syndrome using overnight oximetry for prioritising adenotonsillectomy in a limited-resource setting.

Int J Pediatr Otorhinolaryngol 2021 Nov 30;152:110988. Epub 2021 Nov 30.

Division of Otorhinolaryngology-Head and Neck Surgery, University of Cape Town, Cape Town, South Africa; Red Cross War Memorial Children's Hospital, Cape Town, South Africa.

Background: In resource-poor settings with limited surgical services, it is essential to identify and prioritise children with severe and very severe obstructive sleep apnoea syndrome (OSAS) to expedite surgery. McGill's Oximetry Score (MOS) has been validated against polysomnography for OSAS and is affordable and easy to use.

Aims: The aim of this study was to assess the correlation of tonsillar size and clinical symptoms with MOS grade 3 or 4, to identify who requires overnight oximetry and who to prioritise for adenotonsillectomy. Read More

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November 2021

Direct left-ventricular global longitudinal strain (GLS) computation with a fully convolutional network.

J Biomech 2021 Nov 27;130:110878. Epub 2021 Nov 27.

Department of Cardiology, College of Medicine, University of South Alabama, 1700 Center Street, Mobile, AL 36604, United States.

This study's purpose was to develop a direct MRI-based, deep-learning semantic segmentation approach for computing global longitudinal strain (GLS), a known metric for detecting left-ventricular (LV) cardiotoxicity in breast cancer. Displacement Encoding with Stimulated Echoes cardiac image phases acquired from 30 breast cancer patients and 30 healthy females were unwrapped via a DeepLabV3 + fully convolutional network (FCN). Myocardial strains were directly computed from the unwrapped phases with the Radial Point Interpolation Method. Read More

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November 2021

Machine learning of treadmill exercise test to improve selection for testing for coronary artery disease.

Atherosclerosis 2021 Nov 30;340:23-27. Epub 2021 Nov 30.

Center for Evidence-based Medicine, Taipei Veterans General Hospital, Taipei, Taiwan; Faculty of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan; Institute of Public Health, National Yang Ming Chiao Tung University College of Medicine, Taipei, Taiwan; Department of Medical Education, Taipei Veterans General Hospital, Taipei, Taiwan. Electronic address:

Background And Aims: The high false-positive rate of the treadmill exercise test (TET) may lead to unnecessary invasive coronary angiography. We aimed to develop a machine learning-based algorithm to improve the diagnostic performance of TET.

Methods: Study included 2325 patients who underwent TET and subsequent coronary angiography within one-year interval. Read More

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November 2021

Enhanced single-cell RNA-seq workflow reveals coronary artery disease cellular cross-talk and candidate drug targets.

Atherosclerosis 2021 Nov 26;340:12-22. Epub 2021 Nov 26.

Center for Public Health Genomics, University of Virginia, Charlottesville, VA, 22908, USA; Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, VA , 22908, USA; Department of Public Health Sciences, University of Virginia, Charlottesville, VA, 22908, USA. Electronic address:

Background And Aims: The atherosclerotic plaque microenvironment is highly complex, and selective agents that modulate plaque stability are not yet available. We sought to develop a scRNA-seq analysis workflow to investigate this environment and uncover potential therapeutic approaches. We designed a user-friendly, reproducible workflow that will be applicable to other disease-specific scRNA-seq datasets. Read More

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November 2021

An Observational Data Meta-Analysis on the Differences in Prevalence and Risk Factors Between MAFLD vs NAFLD.

Clin Gastroenterol Hepatol 2021 Dec 3. Epub 2021 Dec 3.

Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Division of Gastroenterology and Hepatology, Department of Medicine, National University Hospital, Singapore; National University Centre for Organ Transplantation, National University Health System, Singapore. Electronic address:

Background And Aims: The shift to redefine non-alcoholic fatty liver disease (NAFLD) as metabolic associated fatty liver disease (MAFLD) can profoundly affect patient care, healthcare professionals, and progress within the field. To date, there remains no consensus on the characterization of NAFLD versus MAFLD. Thus, this study sought to compare the differences between the natural history of NAFLD and MAFLD. Read More

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December 2021

Pregnancy, Preeclampsia and Maternal Aging: From Epidemiology to Functional Genomics.

Ageing Res Rev 2021 Dec 3:101535. Epub 2021 Dec 3.

Department of Obstetrics and Gynecology, Columbia University Irving Medical Center, New York, NY, USA; Department of Genetics and Development, Columbia University Irving Medical Center, New York, NY, USA. Electronic address:

Women live longer than men but experience greater disability and a longer period of illness as they age. Despite clear sex differences in aging, the impact of pregnancy and its complications, such as preeclampsia, on aging is an underexplored area of geroscience. This review summarizes our current knowledge about the complex links between pregnancy and age-related diseases, including evidence from epidemiology, clinical research, and genetics. Read More

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December 2021

Capillary hemodynamics and contracting skeletal muscle oxygen pressures in male rats with heart failure: Impact of soluble guanylyl cyclase activator.

Nitric Oxide 2021 Dec 3. Epub 2021 Dec 3.

Department of Kinesiology, Kansas State University, Manhattan, KS, USA; Department of Anatomy and Physiology, Kansas State University, Manhattan, KS, USA.

In heart failure with reduced ejection fraction (HFrEF), nitric oxide-soluble guanylyl cyclase (sGC) pathway dysfunction impairs skeletal muscle arteriolar vasodilation and thus capillary hemodynamics, contributing to impaired oxygen uptake (V̇O) kinetics. Targeting this pathway with sGC activators offers a new treatment approach to HFrEF. We tested the hypotheses that sGC activator administration would increase the O delivery (Q̇O)-to-V̇O ratio in the skeletal muscle interstitial space (POis) of HFrEF rats during twitch contractions due, in part, to increases in red blood cell (RBC) flux (f), velocity (V), and capillary hematocrit (Hct). Read More

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December 2021

A Proposal to Accelerate Widespread Implementation of Geriatric Cardiology.

Trends Cardiovasc Med 2021 Dec 3. Epub 2021 Dec 3.

Department of Medicine, Columbia University (New York, NY).

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December 2021

Aetiology of resuscitated out-of-hospital cardiac arrest treated at hospital.

Resuscitation 2021 Dec 3. Epub 2021 Dec 3.

School of Medicine, University of Adelaide; Department of Cardiology, Northern Adelaide Local Health Network.

Introduction: Precipitating aetiology of out-of-hospital cardiac arrest (OHCA), as confirmed by diagnostic testing or autopsy, provides important insights into burden of OHCA and has potential implications for improving OHCA survivorship. This study aimed to describe the aetiology of non-traumatic resuscitated OHCAs treated at hospital within a local health network according to available documentation, and to investigate differences in outcome between aetiologies.

Methods: Observational retrospective cohort study of consecutive OHCA treated at hospital within a local health network between 2011-2016. Read More

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December 2021

Gender-related differences in the impact of COVID-19 pandemic in cardiometabolic patients in Latin America: The CorCOVID LATAM Gender sub-study.

Curr Probl Cardiol 2021 Dec 3:101075. Epub 2021 Dec 3.

Department of Medicine, Queen's University, Kingston, Ontario, Canada. Electronic address:

Background: COVID-19 pandemic and lockdown measures have disrupted lifestyle habits and self-care. Gender differences in health behavior during the pandemic have not yet been fully elucidated.

Aim: To evaluate gender-related differences in the impact of COVID-19 pandemic on patients with cardiometabolic diseases. Read More

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December 2021

Cardiac inflammation and microvascular procoagulant changes are decreased in second wave compared to first wave deceased COVID-19 patients.

Int J Cardiol 2021 Dec 3. Epub 2021 Dec 3.

Dept. of Pathology and ACS, AUMC, location VUmc, the Netherlands. Electronic address:

Background: Compelling evidence has shown cardiac involvement in COVID-19 patients. However, the overall majority of these studies use data obtained during the first wave of the pandemic, while recently differences have been reported in disease course and mortality between first- and second wave COVID-19 patients. The aim of this study was to analyze and compare cardiac pathology between first- and second wave COVID-19 patients. Read More

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December 2021

Clinical and echocardiographic characteristics of patients with pathology proven right-sided papillary fibroelastomas.

Int J Cardiol 2021 Dec 3. Epub 2021 Dec 3.

Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, USA. Electronic address:

Background: Papillary fibroelastoma (PFE) are one of the most common primary cardiac neoplasms. They are most commonly found on cardiac valves especially on the left side of the heart and have been associated with an increased risk of embolization. To date, no large studies looked at the clinical significance of right-sided PFE (R-PFE). Read More

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December 2021

Corrigendum to "Lethal giant larvae 1 inhibits smooth muscle calcification via high mobility group box 1" [J Mol Cell Cardiol. 2020;142:39-52].

J Mol Cell Cardiol 2021 Dec 3. Epub 2021 Dec 3.

The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education, Chinese National Health Commission and Chinese Academy of Medical Sciences, The State and Shandong Province Joint Key Laboratory of Translational Cardiovascular Medicine, Department of Cardiology, Qilu Hospital of Shandong University, Jinan, China; School of Pharmacy, Hubei University of Science and Technology, Xianning, Hubei, China. Electronic address:

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December 2021

Haematological profile of COVID-19 patients from a centre in Singapore.

Hematology 2021 Dec;26(1):1007-1012

Department of Cardiology, National University Heart Centre Singapore, Singapore.

Background: Haematological markers such as absolute lymphopenia have been associated with severe COVID-19 infection. However, in the literature to date, the cohorts described have typically included patients who were moderate to severely unwell with pneumonia and who required intensive care stay. It is uncertain if these markers apply to a population with less severe illness. Read More

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December 2021

Effects of nicorandil on systemic inflammation and oxidative stress induced by percutaneous coronary intervention in patients with coronary heart disease.

J Int Med Res 2021 Dec;49(12):3000605211058873

Ultrasound in Cardiac Electrophysiology and Biomechanics Key Laboratory of Sichuan Province, Sichuan Provincial People's Hospital, Chinese Academy of Sciences Sichuan Translational Medicine Research Hospital, University of Electronic Science and Technology of China, Chengdu, Sichuan, P.R. China.

Objective: The present study investigated the effects of a bolus intracoronary injection of nicorandil on systemic inflammation and oxidative stress induced by percutaneous coronary intervention (PCI) in patients with coronary heart disease (CHD).

Methods: Patients undergoing coronary angiography (CAG) were enrolled into the CAG group (n = 30). Patients undergoing PCI were randomly divided into the PCI (n = 30) and PCI + nicorandil groups (n = 30). Read More

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December 2021

Clinical outcome in patients with end-stage heart failure who underwent continuous-flow left ventricular assist devices in a single center.

Korean J Intern Med 2021 Dec 7. Epub 2021 Dec 7.

Division of Cardiology, Department of Medicine, Heart Vascular Stroke Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

Background/aims: The continuous flow left ventricular assist device (cf-LVAD) has improved the survival of chronic end-stage heart failure (HF) patients. Here we describe our clinical experience of the initial 50 LVAD patients from a single center.

Methods: A total of 50 patients underwent LVAD implantation as bridge to transplantation (BTT; n = 28, 56%), bridge to candidacy (BTC; n = 2, 4%), or as destination therapy (DT; n = 20, 40%) from 2012 to 2019. Read More

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December 2021

Clinical utility of non-contact charge density 'SuperMap' algorithm for the mapping and ablation of organized atrial arrhythmias.

Europace 2021 Dec 6. Epub 2021 Dec 6.

Department of Cardiology, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.

Aims: SuperMap is a novel non-contact algorithm for the mapping of organized atrial arrhythmias. We prospectively evaluated SuperMap during mapping and ablation of atrial tachycardias (ATs) and paced rhythms and compared to conventional high-density contact mapping.

Methods And Results: Consecutive patients undergoing SuperMap guided ablation of pre-existing ATs or AT developed during atrial fibrillation ablation procedures were included together with maps obtained during pacing to assess block in linear lesions. Read More

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December 2021

Balancing normalcy and safety: health-related needs in patients with a ventricular assist device within their home environment.

Eur J Cardiovasc Nurs 2021 Dec 6. Epub 2021 Dec 6.

Albert-Ludwigs University of Freiburg, Faculty of Medicine, Institute of Nursing Science, Breisacher Str. 153, 79110 Freiburg, Germany.

Aims: Ventricular assist device (VAD) implantation has become a well-established treatment strategy for patients suffering from advanced heart failure. Ventricular assist device treatment attempts to ameliorate the symptom burden but may create new challenges in patients' lives. Lacking are insights into perceived challenges and health-related needs of patients with VAD within their home environment. Read More

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December 2021

Does mechanical dyssynchrony in addition to QRS area ensure sustained response to cardiac resynchronization therapy?

Eur Heart J Cardiovasc Imaging 2021 Dec 6. Epub 2021 Dec 6.

Department of Cardiology, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands.

Aims: Judicious patient selection for cardiac resynchronization therapy (CRT) may further enhance treatment response. Progress has been made by using improved markers of electrical dyssynchrony and mechanical discoordination, using QRSAREA, and systolic rebound stretch of the septum (SRSsept) or systolic stretch index (SSI), respectively. To date, the relation between these measurements has not yet been investigated. Read More

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December 2021

Dual antithrombotic treatment in chronic coronary syndrome: European Society of Cardiology criteria vs. CHADS-P2A2RC score.

Eur Heart J 2021 Dec 6. Epub 2021 Dec 6.

Department of Cardiology, Aarhus University Hospital, Palle Juul-Jensens Boulevard 99, Aarhus 8200, Denmark.

Aims : According to the 2019 European Society of Cardiology (ESC) guidelines on chronic coronary syndromes (CCS), adding a P2Y12 inhibitor or rivaroxaban to aspirin should be considered in high-risk patients. We estimated the proportion of patients eligible for treatment with the ESC criteria and examined if a recently validated risk score (CHADS-P2A2RC) could improve risk prediction.

Methods And Results : We included 61 338 CCS patients undergoing first-time coronary angiography in Western Denmark (2003-16) and classified them according to the ESC criteria and the CHADS-P2A2RC score. Read More

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December 2021

Late-onset Amplatzer-related endocarditis.

Eur Heart J Cardiovasc Imaging 2021 Dec 6. Epub 2021 Dec 6.

Cardiology and Cardiac Surgery Departments, Parma University Hospital, Via Gramsci, 14, 43123 Parma, Italy.

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December 2021

Sex-Specific Absolute Delta Thresholds for High-Sensitivity Cardiac Troponin T.

Clin Chem 2021 Dec 6. Epub 2021 Dec 6.

Department of Pathology and Molecular Medicine, McMaster University, Hamilton, ON, Canada.

Background: Sex differences in high-sensitivity cardiac troponin (hs-cTn) concentrations from healthy populations have led to the establishment of sex-specific upper reference limits for hs-cTn assays. This study assessed the performance of sex-specific delta (i.e. Read More

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December 2021

Fontan conversion for Fontan failure: lessons from a vanishing craft.

Eur J Cardiothorac Surg 2021 Dec 6. Epub 2021 Dec 6.

Department for Pediatric Cardiology and Congenital Heart Disease, German Heart Center Berlin, Berlin, Germany.

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December 2021

Effects of regular breakfast habits on metabolic and cardiovascular diseases: A protocol for systematic review and meta-analysis.

Medicine (Baltimore) 2021 Nov;100(44):e27629

Department of Interventional Therapy, Affiliated Hospital of Qinghai University, Xining, China.

Background: Breakfast, which is considered as an important meal of the day, is being ignored by an increasing number of people as the pace of modern life accelerates. Although a large number of previous studies have reported the relationship between skipping breakfast and type 2 diabetes mellitus, most of them were cross-sectional studies. It remains unclear how skipping breakfast affects such specific cardio-metabolic diseases as hypertension, strokes and hypercholesterolemia. Read More

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November 2021

Risk of bleeding with ticagrelor in elderly patients over 75 years old: A systematic review and meta-analysis.

Medicine (Baltimore) 2021 Nov;100(44):e27398

Prince Sultan Military Medical City, Riyadh, Saudi Arabia.

Background: Bleeding is an untoward outcome in the management of elderly patients with acute coronary syndrome (ACS). Although the potent oral P2Y12 inhibitor, ticagrelor is clinically beneficial, its association with bleeding events in elderly ACS patients (≥75 years) is poorly understood.

Methods: We conducted a systematic search of 7 databases up to May 20, 2020 to identify studies which examined the risk of bleeding (defined according to each study) among elderly ACS patients (≥75 years) receiving ticagrelor compared to clopidogrel. Read More

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November 2021

Drug-coated balloon versus drug-eluting stent in acute myocardial infarction: A protocol for systematic review and meta-analysis.

Medicine (Baltimore) 2021 Nov;100(44):e27259

Department of Cardiology, The Second Affiliated Hospital of Zhejiang University School of Medicine, Zhejiang, China.

Background: Previous studies comparing the published literature on drug-eluting stents (DES) and drug-coated balloon (DCB) have drawn divergent conclusions, as these studies are limited by small sample sizes. To overcome these limitations, we thus conducted a high-quality systematic review and meta-analysis to assess the efficacy and safety of DCB versus DES for patients with acute myocardial infarction (AMI). It was hypothesized that DCB use at the AMI is associated with decreased risk of cardiovascular disease and death. Read More

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November 2021