9,137 results match your criteria Cardioembolic Stroke

Meniscus Sign in Patients with Anterior Circulation Large Vessel Occlusion Stroke does not Predict Outcome.

Clin Neuroradiol 2022 Jun 24. Epub 2022 Jun 24.

Department of Neurology, University Hospital, RWTH Aachen University, Pauwelsstr. 30, 52074, Aachen, Germany.

Purpose: The angiographic appearance of the occlusion site was suggested to influence outcomes of stroke patients with large vessel occlusion (LVO) who undergo endovascular treatment (EVT). We aimed to study the impact of the meniscus sign (MS) on outcomes of stroke patients with anterior circulation LVO.

Methods: Based on two prospective registries of acute ischemic stroke, we selected patients with carotid‑T, M1 or M2 occlusion who underwent EVT. Read More

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Ipsilateral Carotid Plaque Presence is Inversely Associated with Patent Foramen Ovale in Cryptogenic Stroke: A Multicenter CohortStudy.

J Stroke Cerebrovasc Dis 2022 Jun 21;31(8):106606. Epub 2022 Jun 21.

Cooper Neurological Institute, Cooper University Hospital, Camden, NJ USA. Electronic address:

Background: Embolic stroke of undetermined source (ESUS) accounts for up to 20% of all strokes. Potential contributors to ESUS include patent foramen ovale (PFO) and non-stenotic plaque (<50%, NSP) of the ipsilateral internal carotid artery (ICA). To better differentiate these as unique mechanisms, we explored the prevalence of each in a multicenter observational cohort. Read More

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Ischemic stroke in patients that recover from COVID-19: Comparisons to historical stroke prior to COVID-19 or stroke in patients with active COVID-19 infection.

PLoS One 2022 24;17(6):e0270413. Epub 2022 Jun 24.

University of Alberta, Edmonton, Alberta, Canada.

Background And Purpose: Understanding the relationship of COVID-19 to stroke is important. We compare characteristics of pre-pandemic historical stroke (Pre-C), cases in acute COVID infection (Active-C) and in patients who have recovered from COVID-19 infection (Post-C).

Methods: We interrogated the Qatar stroke database for all stroke admissions between Jan 2019 and Feb 2020 (Pre-C) to Active-C (Feb2020-Feb2021) and Post-C to determine how COVID-19 affected ischemic stroke sub-types, clinical course, and outcomes prior to, during and post-pandemic peak. Read More

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Sports Imaging of COVID-19: A Multi-Organ System Review of Indications and Imaging Findings.

Sports Health 2022 Jun 23:19417381221106448. Epub 2022 Jun 23.

Department of Radiology, NYU Grossman School of Medicine, New York, New York.

Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was first identified in December 2019 in Wuhan, China. Although coronavirus disease-19 (COVID-19) affects every population group, the sports community and athletes require special consideration of the effects on cardiovascular, musculoskeletal, neurologic, and respiratory systems. A comprehensive understanding of imaging indications, findings, and features of COVID-19 supports appropriate imaging utilization and effective patient management and treatment. Read More

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Microembolic Signals in Arteries of the Base of the Brain after Ischemic Stroke.

Bull Exp Biol Med 2022 Jun 23. Epub 2022 Jun 23.

Research Center of Radiology and Clinical Physiology, Federal Center of Brain Research and Neurotechnologies, Federal Medical-Biological Agency of Russia, Moscow, Russia.

Embolic strokes make up a significant proportion of acute cerebrovascular accidents. Doppler blood flow monitoring with microembolodetection allows suggesting the embolic nature of cerebral infarction. The aim of this study was to identify factors associated with the presence of microembolic signals in patients with ischemic stroke. Read More

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Atrial Fibrillation and Acute Ischemic Stroke: Evaluation of the Contemporary 2018 National Inpatient Sample Database.

CJC Open 2022 Jun 10;4(6):513-519. Epub 2022 Feb 10.

Tulane Research Innovation for Arrhythmia Discoveries, Tulane University School of Medicine, New Orleans, Louisiana, USA.

Background: Atrial fibrillation (AF) in acute ischemic stroke (AIS) is considered a binary entity regardless of AF type. We aim to investigate in-hospital morbidity and mortality among patients with nonparoxysmal AF-related AIS.

Methods: Patients hospitalized for AIS with associated paroxysmal or persistent AF were identified from the 2018 national inpatient sample database. Read More

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Abdominal aortic aneurysm rupture presenting with focal weakness and altered mental status: a case report.

Int J Emerg Med 2022 Jun 22;15(1):28. Epub 2022 Jun 22.

Philadelphia College of Osteopathic Medicine, 4170 City Ave, PhiladelphiaPhiladelphia, PA, 19131, USA.

Background: Abdominal aortic aneurysms (AAA) can present asymptomatically and may be found through routine screening or seen incidentally on imaging. Rupture due to weaking of the aortic wall is the main complication of an AAA and leads to approximately 200,000 deaths annually worldwide. Clinically, AAA rupture most frequently presents with abdominal and/or back pain, pulsatile abdominal mass, and hypotension. Read More

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Early recurrence in patients with symptomatic, non-cardioembolic, internal carotid artery occlusion.

J Stroke Cerebrovasc Dis 2022 Jun 19;31(8):106571. Epub 2022 Jun 19.

Department of Neurology, Kyoto Second Red Cross Hospital, Kyoto, Japan.

Introduction: There are limited data on the clinical course of patients with non-cardioembolic, mostly atherosclerotic, internal carotid artery occlusion (ICAO). The purpose of this study was to elucidate the frequency and underlying pathogenesis of early recurrent ischemic stroke in symptomatic non-cardioembolic ICAO.

Materials And Methods: Consecutive patients with symptomatic non-cardioembolic ICAO were retrospectively reviewed. Read More

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A Review of the Role of Transthoracic and Transesophageal Echocardiography, Computed Tomography, and Magnetic Resonance Imaging in Cardioembolic Stroke.

Med Sci Monit 2022 Jun 22;28:e936365. Epub 2022 Jun 22.

Department of Neurology, "Victor Babeș" University of Medicine and Pharmacy, Timisoara, Romania.

Stroke is a major source of morbidity and mortality worldwide, accounting for the second largest cause of mortality and the third greatest cause of disability. Stroke is frequently preceded by a transient ischemic attack (TIA). The etiologies of 20-30% of ischemic strokes are unknown, and thus are termed "cryptogenic strokes". Read More

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Antithrombotic dilemmas in stroke medicine: new data, unsolved challenges.

J Neurol Neurosurg Psychiatry 2022 Jun 21. Epub 2022 Jun 21.

Stroke Research Centre, UCL Queen Square Institute of Neurology, London, UK

Antithrombotic therapy is a key element of secondary prevention in patients who have had an ischaemic stroke or transient ischaemic attack. However, its use in clinical practice is not always straightforward. This review provides an update on certain difficult scenarios in antithrombotic management, with a focus on recent clinical trials and large observational studies. Read More

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The changing use of anticoagulants in New Zealand.

N Z Med J 2022 May 6;135(1554):35-43. Epub 2022 May 6.

Consultant Haematologist, Dept. of Clinical Haematology, Palmerston North Hospital, Palmerston North.

Aims: To assess the change in the use of oral anticoagulants in New Zealand over 10 years since the introduction of dabigatran and rivaroxaban.

Methods: Data were collected from the National Pharmaceutical database from January 2011 to March 2021. Seven and a half million prescriptions for oral anticoagulants were analysed. Read More

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Infective endocarditis in patients with rheumatic heart disease: a single-centre retrospective comparative study.

N Z Med J 2022 Feb 25;135(1550):62-73. Epub 2022 Feb 25.

Cardiologist, Green Lane Cardiovascular Service, Auckland City Hospital.

Aims: We reviewed the baseline characteristics and outcomes of patients with infective endocarditis (IE) and compared those with and without rheumatic heart disease (RHD).

Methods: We retrospectively reviewed patients ≥15 years with IE treated at Auckland City Hospital between January 2016 and December 2018 and excluded device-related IE and complex congenital heart disease. RHD status was based on echocardiographic features or previous history of rheumatic fever with valvular disease. Read More

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February 2022

Bacterial Signatures of Cerebral Thrombi in Large Vessel Occlusion Stroke.

mBio 2022 Jun 21:e0108522. Epub 2022 Jun 21.

Department of Neurology, The First Affiliated Hospital, Jinan University, Guangzhou, China.

It is important to understand the microbial features of the cerebral thrombus and its clinical relevance in stroke patients, of which data were scarce. We aimed to investigate the microbial features of cerebral thrombi retrieved via thrombectomy in stroke patients with large vessel occlusion (LVO) and their correlations with 3-month mortality. In a prospective cohort study, thrombus samples were collected during mechanical thrombectomy in LVO stroke patients with successful revascularization at a tertiary hospital. Read More

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Cerebral safety after pulsed field ablation for paroxysmal atrial fibrillation.

Heart Rhythm 2022 Jun 16. Epub 2022 Jun 16.

Department of Electrophysiology, Alfried Krupp Krankenhaus, Essen, Germany; Department of Medicine, Witten/Herdecke University, Witten, Germany.

Background: Pulsed field ablation (PFA) is a novel, nonthermal ablation modality that can ablate myocardial tissue with minimal effect on surrounding tissue. Preclinical data show absence of cerebral emboli after extensive PFA. However, clinical data SCL /SCE after PFA are lacking. Read More

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DNA Methylation and Ischemic Stroke Risk: An Epigenome-Wide Association Study.

Thromb Haemost 2022 Jun 19. Epub 2022 Jun 19.

Institut d'Investigació Biomèdica Sant Pau (IIB SANT PAU), Sant Quintí, Barcelona, Spain.

Background: Ischemic stroke (IS) risk heritability is partly explained by genetics. Other heritable factors, such as epigenetics, could explain an unknown proportion of the IS risk. The objective of this study is to evaluate DNA methylation association with IS using epigenome-wide association studies (EWAS). Read More

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Danhong injection combined with tPA protects the BBB through Notch-VEGF signaling pathway on long-term outcomes of thrombolytic therapy.

Biomed Pharmacother 2022 Jun 16;153:113288. Epub 2022 Jun 16.

College of Life Science, Zhejiang Chinese Medical University, 548 Binwen Road, Binjiang District, Hangzhou 310053, China. Electronic address:

Current therapy for ischemic stroke primarily relies on tissue plasminogen activator (tPA), but it is limited by narrow treatment time window, bleeding complications and neurotoxicity. The preliminary study of tPA plus Danhong injection (DHI) shows that it can significantly reduce the side effects of tPA and improve its thrombolytic effect, but the mechanism of this action has not been further studied. In this study, the rats were randomly divided into sham group, vehicle group, DHI group (4 mL/kg), tPA group (5 mg/kg) and DHI+tPA group (4 mL/kg+ 2. Read More

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Predicting Transcarotid Artery Revascularization adverse outcomes by Imaging Characteristics.

Ann Vasc Surg 2022 Jun 14. Epub 2022 Jun 14.

Department of Thoracic and Cardiovascular Surgery, Allegheny Health Network, Pittsburgh, Pennsylvania.

Objectives: Approximately 20-30% of ischemic strokes are caused by internal carotid artery stenosis. Stroke is the leading cause of disability and the second leading cause of death in the United States. Second generation Trans Carotid Arterial Revascularization (TCAR) stenting, using the ENROUTE flow reversal technology to prevent embolic stroke during the stenting process, has demonstrated stroke and death outcomes equivalent to CEA with reduced cranial nerve injury. Read More

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A Case Report of Thromboembolic Stroke in a Patient with Holt-Oram Syndrome.

J Community Hosp Intern Med Perspect 2022 2;12(3):89-93. Epub 2022 May 2.

McLaren Health Care, Flint/ Michigan State University, Cardiology Department, 401 S Ballenger Hwy, Flint, MI, 48532, USA.

Ischemic stroke associated with rare clinical syndromes represents less than 5% of etiologic factors. From those syndromes are Holt-Oram syndrome and Left ventricular non-compaction syndrome. We report a case of a 66 years old male with genetically confirmed Holt-Oram syndrome due to TBX5 mutation who presented with cryptogenic stroke most likely due to cardioembolic etiology. Read More

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Where is the Thrombus ? Mural Ascending Aortic Thrombus with Embolic Events in a Patient with Recent COVID 19 Infection.

J Community Hosp Intern Med Perspect 2022 2;12(3):83-85. Epub 2022 May 2.

Department of Cadiology, Trinitas Regional Medical Center, Elizabeth, NJ, USA.

The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has triggered a global health pandemic that led to substantial morbidity and mortality worldwide. The virus has been known to predominantly cause severe hypoxemic respiratory failure but there have been multiple reports of extra-pulmonary manifestations. Additionally, there has been increasing evidence of COVID-19 hyper-coagulability. Read More

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Genetically predicted higher educational attainment decreases the risk of stroke: a multivariable Mendelian randomization study.

BMC Cardiovasc Disord 2022 Jun 16;22(1):269. Epub 2022 Jun 16.

Department of Neurosurgery, The Affiliated Hospital of Guizhou Medical University, Guizhou Medical University, Guizhou, 610041, China.

Background: The causal association between educational attainment (EA) and stroke remains unclear. Hence, a novel multivariable Mendelian randomization (MVMR) approach was applied to solve this issue.

Methods: The single nucleotide polymorphisms (SNPs) from a recent genome-wide association study (GWAS) on years of schooling served as instruments. Read More

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Preprocedural determination of an occlusion pathomechanism in endovascular treatment of acute stroke: a machine learning-based decision.

J Neurointerv Surg 2022 Jun 16. Epub 2022 Jun 16.

Department of Neurosurgery, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.

Objective: To evaluate whether an occlusion pathomechanism can be accurately determined by common preprocedural findings through a machine learning-based prediction model (ML-PM).

Methods: A total of 476 patients with acute stroke who underwent endovascular treatment were retrospectively included to derive an ML-PM. For external validation, 152 patients from another tertiary stroke center were additionally included. Read More

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New strategy for clinical etiologic diagnosis of acute ischemic stroke and blood biomarker discovery based on machine learning.

RSC Adv 2022 May 16;12(23):14716-14723. Epub 2022 May 16.

Center for Clinical Laboratories, The Affiliated Hospital of Guizhou Medical University Guiyang 550014 China.

Acute ischemic stroke (AIS) is a syndrome characterized by high morbidity, prevalence, mortality, recurrence and disability. The longer the delay before proper treatment of a stroke, the greater the likelihood of brain damage and disability. Computed tomography and nuclear magnetic resonance are the primary choices for fast diagnosis of AIS in the early stage, which can provide certain information about infarction location and degree, and even the vascular distribution of lesions responsible for strokes. Read More

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Prevalence of Left Atrial Septal Pouch Among Patients with Embolic Stroke of Undetermined Source Or Stroke of Known Etiology: a Retrospective Study.

J Transl Int Med 2022 Mar 9;10(1):48-55. Epub 2022 Apr 9.

Cardiology Department, CHU Brugmann, Université Libre de Bruxelles, Brussels 1020, Belgium.

Background And Objectives: Cryptogenic strokes can be defined by the criteria established for an embolic stroke of undetermined source (ESUS). Some embolic events might be caused by a left atrial septal pouch (LASP), due to the potential of thrombus formation. In this study we aimed to determine if LASP is a risk factor for ESUS when compared to a population of strokes of known origin, the LASP screening rate in our institution and if LASP dimensions influences the risk of ESUS. Read More

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Effectiveness and safety of non-vitamin K direct oral anticoagulants in atrial fibrillation patients with bioprosthetic valve.

PLoS One 2022 14;17(6):e0268113. Epub 2022 Jun 14.

Department of Internal Medicine, Seoul National University Hospital, Seoul, Republic of Korea.

Background: Non-vitamin K direct oral anticoagulant (DOAC) is effective for prevention of embolic events in nonvalvular atrial fibrillation (AF) patients. However, the effectiveness and safety of DOAC in AF patients who have bioprosthetic heart valve (BPHV) is largely unknown.

Methods: We retrospectively identified patients with AF and BPHV, using the diagnostic code and medical device and surgery information from the Korean National Health Insurance Service database, between 2013 and 2018. Read More

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Frequency, predictors and cardiovascular outcomes associated with transthoracic echocardiographic findings during acute ischaemic stroke hospitalisation.

Stroke Vasc Neurol 2022 Jun 13. Epub 2022 Jun 13.

Department of Cardiology, Massachusetts General Hospital, Boston, Massachusetts, USA.

Objective: To characterise the clinical utility of transthoracic echocardiography (TTE) at the time of acute ischaemic stroke (AIS).

Background: The utility of obtaining a TTE during AIS hospitalisation is uncertain.

Methods: We studied AIS hospitalisations at a single centre (2002-2016). Read More

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Endovascular treatment for acute ischemic stroke after video-assisted thoracoscopic pulmonary lobectomy in patients with lung cancer: A report of four cases and literature review.

J Stroke Cerebrovasc Dis 2022 Jun 10;31(8):106593. Epub 2022 Jun 10.

Department of Endovascular Surgery, Tokyo Medical and Dental University, Tokyo, Japan. Electronic address:

Background: Postoperative cerebral embolic stroke is a serious complication of pulmonary lobectomy, occurring in 1.1% of patients undergoing lobectomy through video-assisted thoracoscopic surgery (VATS). The mechanism of this complication is thought to be embolic stroke caused by thrombus formed due to stagnation in the pulmonary vein stump after VATS lobectomy. Read More

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Recurrent Strokes in Patients With Atrial Fibrillation Treated With Direct Oral Anticoagulant Agents.

Angiology 2022 Jun 12:33197221108394. Epub 2022 Jun 12.

Department of Vascular Neurology, University Clinical Centre Ljubljana, Slovenia.

Recurrent ischemic strokes (IS) in patients treated with direct oral anticoagulant agents (DOACs) are rare. Knowledge regarding the type of recurrent IS and predisposing factors is insufficient. We analyzed a cohort of 1001 patients (77. Read More

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Stroke Caused by Arterial Thoracic Outlet Syndrome in an Adolescent.

Child Neurol Open 2022 Jan-Dec;9:2329048X221105743. Epub 2022 Jun 7.

Division of Pediatric Neurology, Department of Neurology, The Johns Hopkins School of Medicine, Baltimore, MD, USA.

Arterial thoracic outlet syndrome is a rare condition characterized by compression of the subclavian artery, often with post-stenotic aneurysm formation. Artery-to-artery embolic strokes related to thoracic outlet syndrome have been reported in the posterior circulation and in the ipsilateral anterior circulation. We present a case in which a thrombus secondary to thoracic outlet syndrome caused a contralateral anterior circulation stroke in an adolescent and postulate mechanisms of this rare occurrence. Read More

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Evaluating the Potential Pathology and Short-Term Outcomes of Cryptogenic Stroke Using the Etiological Classification System.

J Atheroscler Thromb 2022 Jun 12. Epub 2022 Jun 12.

Department of Neurology, Juntendo University Urayasu Hospital.

Aim: Various embolic sources and pathogenetic mechanisms underlie cryptogenic stroke (CS). We investigated the association of etiological diversity with short-term outcomes in patients with CS using a modified atherosclerosis (A), small-vessel disease (S), cardiac pathology (C), other causes (O), and dissection (D) (ASCOD) system.

Methods: Patients with CS who underwent transesophageal echocardiography were registered in this multicenter, observational study. Read More

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Diagnostic And Prognostic Value Of Left Atrial Function In Identification Of Cardioembolism And Prediction Of Outcomes In Patients With Cryptogenic Stroke.

J Am Soc Echocardiogr 2022 Jun 9. Epub 2022 Jun 9.

Department of Cardiology, Blacktown Hospital, Sydney, NSW 2148, Australia; School of Public Health and Community Medicine, University of New South Wales, Sydney, NSW 2052, Australia; School of Medicine, Western Sydney University, Sydney, NSW 2148, Australia. Electronic address:

Background: Strokes of undetermined source, commonly termed cryptogenic stroke (CS), account for a significant proportion of ischemic stroke etiology and have high rates of stroke recurrence. The heterogeneous etiology of CS makes decisions regarding treatment for such patients challenging. We sought to evaluate the diagnostic and prognostic value of left atrial (LA) function in identification of cardioembolism and prediction of outcomes in patients with CS. Read More

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