2,360 results match your criteria Cardioembolic Stroke


MRI predicts intracranial hemorrhage in patients who receive long-term oral anticoagulation.

Neurology 2019 Apr 19. Epub 2019 Apr 19.

From the Department of Neurology (J.M.-F., L.P.-S., R.M., R.D.-M., A.M.-D., P.C.-R., E.J.-X.) and Epidemiology (I.G.), Hospital de la Santa Creu i Sant Pau, Biomedical Research Institute, Barcelona; Departments of Radiology (S.M.-M.) and Neurology (A.R.-C.), Hospital del Mar-Parc de Salut Mar, Barcelona; Unitat RM IDI (E.M.) and Department of Neurosciences (M.H.-P.), Hospital Germans Trias i Pujol, Badalona; Department of Neurology (M.Z.), Arcispedale Santa Maria Nuova IRCCS, Reggio Emilia, Italy; Department of Neurology (M.G.-C.), Hospital de Sant Joan Despí Moises Broggi, Sant Joan Despí, Spain; Department of Neurology (L. Lara), Hospital de León; Department of Neurology (A.B.), Hospital Universitari Son Espases, Palma de Mallorca; Department of Neurology (A.C.), Hospital de Valladolid; Department of Neurology (A.M.D.A.-B.), Hospital de Donostia; Department of Neurology (Y.B.), Hospital de Burgos; Department of Neurology (B.F.), Hospital Universitario La Paz, Universidad Autónoma de Madrid, Instituto de Investigación IdiPaz, Madrid; Department of Neurology (D. Cánovas), Hospital Parc Taulí, Sabadell; Department of Neurology (L. Llull), Hospital Clínic, Barcelona; Department of Neurology (B.Z.), Hospital de Navarra, Pamplona; Department of Neurology (M.F.), Hospital de Basurto, Bilbao; Department of Neurology (I.C.-N.), Hospital San Pedro de Alcántara, Cáceres; Department of Neurology (J.S.), Hospital Arnau de Vilanova, Lleida; Department of Neurology (D. Cocho), Hospital de Granollers; Department of Neurology (J.K.), F.Ass. Mutua Terrassa; Department of Neurology (E.P.), Hospital de Mataró; Department of Neurology (A.D.F.), Hospital Ramón y Cajal, Madrid; Department of Neurology (M.S.), Hospital La Rioja, Logroño; Department of Neurology (E.Z.-A.), Hospital Virgen del Rocío, Sevilla; Department of Neurology (J.Z.-B.), Hospital Verge de la Cinta, Tortosa; Department of Neurology (I.D.-M.), Hospital de Albacete; Department of Neurology (J.F.-D.), Centro Médico Asturias, Oviedo; Department of Neurology (A.L.), Hospital La Fe, Valencia; Department of Neurology (J.M.), Hospital Virgen de las Nieves, Granada; and Department of Neurology (M.R.-Y.), Hospital Santiago de Compostela, Santiago de Compostela, Spain.

Objective: We tested the hypothesis that the risk of intracranial hemorrhage (ICH) in patients with cardioembolic ischemic stroke who are treated with oral anticoagulants (OAs) can be predicted by evaluating surrogate markers of hemorrhagic-prone cerebral angiopathies using a baseline MRI.

Methods: Patients were participants in a multicenter and prospective observational study. They were older than 64 years, had a recent cardioembolic ischemic stroke, and were new users of OAs. Read More

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http://dx.doi.org/10.1212/WNL.0000000000007532DOI Listing
April 2019
3 Reads

[A strategic roadmap of the Italian Society of Interventional Cardiology (SICI-GISE) to ensure patient's access to appropriate treatment].

G Ital Cardiol (Rome) 2019 Apr;20(4):4-19

A.O. Universitaria di Bologna, Policlinico S. Orsola-Malpighi, Bologna.

In comparison with the international scenario, in Italy the penetration of several important scientific and technological innovations in the field of cardiovascular intervention appears to be inadequate both in terms of number of patients treated with respect to the actual need, and inhomogeneity between the different geographical areas of the country. One of the main institutional objectives of the Italian Society of Interventional Cardiology (SICI-GISE) is to develop a roadmap to guarantee homogeneous access throughout the whole national territory to treatments that are recommended by the major international guidelines. The present document focuses on four main areas of cardiovascular intervention: (i) transcatheter treatment of aortic valve stenosis, (ii) percutaneous mitral valve repair, (iii) prevention of cardioembolic stroke through percutaneous left atrial appendage occlusion in patients with non-valvular atrial fibrillation, (iv) optimization of coronary revascularization with the aid of the functional study of coronary lesions. Read More

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http://dx.doi.org/10.1714/3146.31274DOI Listing
April 2019
4 Reads

Left ventricular wall motion abnormality is associated with cryptogenic stroke.

Int J Stroke 2019 Apr 13:1747493019834181. Epub 2019 Apr 13.

6 Department of Neurology, Korea University College of Medicine, Korea University Anam Hospital, Seoul, Republic of Korea.

Background: Left ventricular wall motion abnormality (LVWMA) unrelated to known cardiac risk factors is an uncertain risk for stroke.

Aims: We evaluated whether LVWMA was associated with cryptogenic stroke.

Methods: This retrospective, observational study included 4316 acute ischemic stroke patients, and the association between cryptogenic stroke and LVWMA was examined in comparison with other stroke subtypes. Read More

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http://dx.doi.org/10.1177/1747493019834181DOI Listing
April 2019
1 Read

How to best prevent cardioembolic stroke?

Authors:
Matthias Wilhelm

Eur J Prev Cardiol 2019 Apr 11:2047487319842250. Epub 2019 Apr 11.

Department of Cardiology, Inselspital, Bern University Hospital, University of Bern, Switzerland.

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http://dx.doi.org/10.1177/2047487319842250DOI Listing

Left atrial appendage occlusion in patients older than 85 years. Safety and efficacy in the EWOLUTION registry.

Rev Esp Cardiol (Engl Ed) 2019 Apr 5. Epub 2019 Apr 5.

Cardiologie, St Antonius Hospital, Nieuwegein, The Netherlands.

Introduction And Objectives: Elderly patients with atrial fibrillation are at greater risk of both cardioembolic events and major bleeding than younger patients. Left atrial appendage occlusion (LAAO) could be an attractive alternative for these patients, but there are limited data on outcomes with LAAO in patients ≥ 85 years old. The aim of the present study was to assess the safety and efficacy of LAAO in patients ≥ 85 years old. Read More

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http://dx.doi.org/10.1016/j.rec.2019.02.008DOI Listing
April 2019
1 Read

Accurate etiology diagnosis in patients with stroke and atrial fibrillation: A role for brain natriuretic peptide.

J Neurol Sci 2019 May 29;400:153-157. Epub 2019 Mar 29.

Department of Neurological Science, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan.

Background: Atrial fibrillation (AF) is the leading cause of cardioembolic stroke (CES), and patients with stroke and AF are frequently assumed to have CES. However, strokes presumably due to atherosclerotic pathophysiologies in large or small vessels can also occur in patients with AF. The aims of the present study were to clarify the prevalence of and factors related to a non-cardioembolic etiology in acute stroke patients with AF. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0022510X193015
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http://dx.doi.org/10.1016/j.jns.2019.03.031DOI Listing
May 2019
5 Reads

Multimodality imaging of left atrium in patients with atrial fibrillation.

J Cardiovasc Comput Tomogr 2019 Mar 30. Epub 2019 Mar 30.

Centro Cardiologico Monzino, IRCCS, Milan, Italy. Electronic address:

Atrial fibrillation (AF) is the most common arrhythmia worldwide associated with significant morbidity and mortality and represents a significant health care burden. Goals of AF treatment include prevention of cardioembolic stroke using anticoagulation and device therapy and restoration of sinus rhythm using antiarrhythmic drugs or catheter ablation techniques. A comprehensive assessment of cardiac chamber size and function is often started with echocardiography as a first line diagnostic imaging strategy. Read More

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http://dx.doi.org/10.1016/j.jcct.2019.03.005DOI Listing
March 2019
1 Read

Cardiac imaging after ischemic stroke : Echocardiography, CT, or MRI?

Herz 2019 Apr 2. Epub 2019 Apr 2.

Department of General and Interventional Cardiology, Building O70, University Heart Center Hamburg, Martinistraße 52, 20246, Hamburg, Germany.

About 20-25% of all ischemic strokes are of cardioembolic etiology, with atrial fibrillation and heart failure as the most common underlying pathologies. Diagnostic work-up by noninvasive cardiac imaging is essential since it may lead to changes in therapy, e.g. Read More

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http://dx.doi.org/10.1007/s00059-019-4803-xDOI Listing
April 2019
3 Reads

Cerebral blood flow territory instability in patients with atherosclerotic intracranial stenosis.

J Magn Reson Imaging 2019 Apr 2. Epub 2019 Apr 2.

Department of Radiology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.

Background: Stroke risk stratification in patients with symptomatic intracranial atherosclerotic arterial disease (ICAD) remains an important clinical objective owing to the high 14-19% recurrent stroke rate in these patients on standard-of-care medical management. There thus remains a need for hemodynamic markers that may allow for the selection of personalized therapies for high-risk symptomatic patients.

Purpose: To determine if shifting of cerebral blood flow (CBF) territories in response to changes in cerebral perfusion pressure (CPP) may provide a marker for stroke risk in ICAD patients. Read More

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http://dx.doi.org/10.1002/jmri.26737DOI Listing
April 2019
2 Reads

[An autopsy case after endovascular thrombectomy for cardioembolic stroke due to nonbacterial thrombotic endocarditis].

Rinsho Shinkeigaku 2019 Mar 30. Epub 2019 Mar 30.

Department of Neurology, National Hospital Organization Kyoto Medical Center.

A 73-year-old women visited emergency department because of sudden right hemiplegia. She had a history of duodenum papilla cancer terminal stage and multiple liver metastasis. On admission, diffusion weighted images revealed high intensity area at left middle cerebral artery territory. Read More

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http://dx.doi.org/10.5692/clinicalneurol.cn-001252DOI Listing
March 2019
1 Read

Predictors of Left Atrial Thrombi and Spontaneous Echocardiographic Contrast in the Acute Phase After Cardioembolic Stroke in Patients With Atrial Fibrillation.

J Stroke Cerebrovasc Dis 2019 Mar 29. Epub 2019 Mar 29.

Department of Internal Medicine, Cardiovascular Division, Hyogo College of Medicine, Nishinomiya, Japan.

Introduction: The underlying mechanism of the residual left atrial thrombus (LAT)/spontaneous echo contrast (SEC) after the onset of cardioembolic stroke (CES) is unknown. This study aims to investigate the utility of CHADS and CHADS-VASc scores for predicting LAT/SEC, and to investigate the risk factors of residual LAT/SEC after CES onset.

Methods: This retrospective study included 124 patients who were admitted with the acute phase of CES at our center. Read More

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http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2019.03.003DOI Listing
March 2019
2 Reads

Recurrent ischemic stroke in atrial fibrillation with non-vitamin K antagonist oral anticoagulation.

J Clin Neurosci 2019 Mar 28. Epub 2019 Mar 28.

Department of Neurology, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Republic of Korea. Electronic address:

The etiology or rate of recurrent ischemic stroke according to dosing methods including drug adherence in patients taking non-vitamin K antagonist oral anticoagulants (NOACs) remain uncertain. We investigated the association between dosing methods including drug adherence achieved with NOACs and the presence of major vessel occlusion (MVO) in patients with ischemic stroke with non-valvular atrial fibrillation (NVAF). From July 2013 through December 2016, 120 patients with recurrent ischemic stroke with NVAF on NOACs were retrospectively analyzed. Read More

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http://dx.doi.org/10.1016/j.jocn.2019.03.037DOI Listing
March 2019
2 Reads

Brainstem stroke caused by left atrial cardiac papillary fibroelastoma: an increasingly recognized rare cause of stroke.

Cardiovasc Pathol 2019 Feb 7;40:65-67. Epub 2019 Feb 7.

Albury Base Hospital NSW, Epworth Eastern Hospital and Melbourne Pathology Victoria, Australia.

Cardiac papillary fibroelastoma is a rare but increasingly recognized cause of embolic stroke that is prevalent in the older population and requires prompt surgical management. We report an unusual case of left atrial appendage cardiac fibroelastoma in a 76-year-old gentleman who presented with left internuclear ophthalmoplegia and ataxia, with corresponding diffusion-weighted imaging on magnetic resonance imaging of the brain. This case illustrates the importance of echocardiographic imaging in the workup of cardioembolic stroke in the older adult population in the acute setting. Read More

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http://dx.doi.org/10.1016/j.carpath.2019.01.007DOI Listing
February 2019

LDL Subclasses in Ischemic Stroke: A Risk Factor?

Noro Psikiyatr Ars 2019 Mar 5;56(1):13-17. Epub 2018 Jul 5.

Department of Cardiology, Balıklıgöl State Hospital, Şanlıurfa, Turkey.

Introduction: Seven low-density lipoprotein (LDL) subclasses are identified, and smaller LDL particles are associated with an increased risk for cardiovascular events. However, there is limited data about the relationship between the acute ischemic stroke (AIS) subtypes and LDL subclasses. The aim of our study is to investigate the relationship between AIS subtypes and LDL subclasses. Read More

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http://dx.doi.org/10.5152/npa.2017.19393DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6427071PMC
March 2019
1 Read

Ischemic stroke of the "hand knob area": A case series and literature review.

J Clin Neurosci 2019 Mar 22. Epub 2019 Mar 22.

Neurology Department, Hospital Británico de Buenos Aires, Argentina.

Isolated hand paresis may reflect an infarction of the "hand knob area", which represents less than 1% of all ischemic strokes. In this type of stroke, a potential source of embolism is often identified. There are no large case series regarding this topic in Latin America. Read More

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http://dx.doi.org/10.1016/j.jocn.2019.03.025DOI Listing
March 2019
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Time Point, Etiology, and Short-Term Outcome of Repeated Mechanical Thrombectomy Due to Recurrent Large Vessel Occlusion.

Front Neurol 2019 8;10:204. Epub 2019 Mar 8.

Department of Radiology and Neuroradiology, Alfried Krupp Krankenhaus, Essen, Germany.

Data on time point and etiology of repeated stroke caused by large brain vessel occlusion (LVO) resulting in repeated mechanical thrombectomy (MT) in acute stroke patients is very limited. We retrospectively reviewed all acute stroke patients treated with MT with stent retrievers or aspiration systems between January 2010 and June 2018 to identify patients who received two or more MT treatments due to recurrent LVO in our tertiary neurovascular center. Short-term outcome was assessed using the NIH stroke scale score at discharge. Read More

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http://dx.doi.org/10.3389/fneur.2019.00204DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6418008PMC

Hemorrhagic Transformation of Arterial Ischemic and Venous Stroke in Children.

Pediatr Neurol 2019 Feb 8. Epub 2019 Feb 8.

Division of Neurology, Children's Hospital of Philadelphia, Departments of Neurology and Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania. Electronic address:

Hemorrhagic transformation can complicate both arterial ischemic stroke and cerebral sinus venous thrombosis. Risk factors for hemorrhagic transformation after adult arterial ischemic stroke include larger infarct volume, cardioembolic stroke, and anticoagulation in the acute period. Large hemorrhagic transformation in adults is associated with poor outcome. Read More

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http://dx.doi.org/10.1016/j.pediatrneurol.2019.01.023DOI Listing
February 2019
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Beneficial effects of pre-stroke statins use in cardioembolic stroke patients with atrial fibrillation: a hospital-based retrospective analysis.

Arch Med Sci 2019 Mar 4;15(2):385-392. Epub 2019 Mar 4.

Cardiovascular Research Centre, University of Zielona Gora, Zielona Gora, Poland.

Introduction: Statins are widely used in stroke patients. The AHA/ASA guidelines recommend aggressive statin therapy in atherosclerotic stroke patients. Their beneficial effects are due to both their hypolipemic and pleiotropic properties. Read More

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http://dx.doi.org/10.5114/aoms.2019.82925DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425215PMC
March 2019
1 Read

Safety and Efficacy of Triple Antithrombotic Therapy with Dabigatran versus Vitamin K Antagonist in Atrial Fibrillation Patients: A Pilot Study.

Biomed Res Int 2019 13;2019:5473240. Epub 2019 Feb 13.

Chair of Cardiology, University of Campania "Luigi Vanvitelli", Naples, Italy.

Background: Combination of dual antiplatelet (DAPT) and oral anticoagulation therapy is required to decrease cardioembolic stroke and stent thrombosis risk in patients with atrial fibrillation (AF) and acute coronary syndrome (ACS). We compared the safety and efficacy of dabigatran etexilate with vitamin K antagonist (VKA), in combination with DAPT (aspirin plus clopidogrel) treatment in AF patients who underwent percutaneous coronary intervention (PCI) with stenting for ACS.

Methods: Consecutive nonvalvular AF patients who received twice-daily dabigatran 110 mg (n = 389) or VKA (n = 510) and DAPT were included. Read More

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http://dx.doi.org/10.1155/2019/5473240DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6393928PMC
February 2019
1 Read

Ischemic stroke in patients previously anticoagulated for non-valvular atrial fibrillation: Why does it happen?

Rev Port Cardiol 2019 Feb 15;38(2):117-124. Epub 2019 Mar 15.

Faculdade de Medicina da Universidade de Coimbra, Coimbra, Portugal; Serviço de Neurologia do Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal. Electronic address:

Introduction: Oral anticoagulants have proved to be highly effective in preventing atrial fibrillation (AF)-related strokes. The occurrence of stroke despite oral anticoagulation is unexpected and little is known about the mechanisms responsible. The aim of this study was to assess possible mechanisms for stroke occurrence, such as poor treatment adherence and inappropriate dosage, in patients chronically anticoagulated for AF. Read More

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http://dx.doi.org/10.1016/j.repc.2018.06.004DOI Listing
February 2019
1 Read

Cerebral infarct topography of atrial fibrillation and Chagas disease.

J Neurol Sci 2019 May 12;400:10-14. Epub 2019 Mar 12.

Universidade Federal Fluminense, D'Or Institute for Research and Education, Rio de Janeiro, Brazil.

Background: Chagas disease (CD) and ischemic stroke (IS) have a significant but poorly understood correlation. There is paucity of evidence regarding secondary prophylaxis of IS and etiological causes.

Objectives: To compare arterial stroke topography and the respective morbidities and mortality in patients with CD of undetermined and cardioembolic etiologies and with cardioembolic IS (atrial fibrillation [AF]). Read More

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http://dx.doi.org/10.1016/j.jns.2019.03.002DOI Listing
May 2019
1 Read

Arterial Spin Labeling Magnetic Resonance Imaging for Differentiating Acute Ischemic Stroke from Epileptic Disorders.

J Stroke Cerebrovasc Dis 2019 Mar 13. Epub 2019 Mar 13.

Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

Background: Differential diagnosis between acute ischemic stroke (AIS) and epilepsy-related stroke mimics is sometimes difficult in the emergency department. We investigated whether a combination of diffusion-weighted imaging (DWI) and arterial spin labeling imaging (ASL) is useful in distinguishing AIS from epileptic disorders.

Methods: The study included suspected AIS patients who underwent emergency MRI including both DWI and ASL, and who exhibited DWI high-intensitylesions corresponding to neurological symptoms. Read More

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http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2019.02.020DOI Listing

A prospective study of serum metabolites and risk of ischemic stroke.

Neurology 2019 Apr 13;92(16):e1890-e1898. Epub 2019 Mar 13.

From the Brown Foundation Institute of Molecular Medicine, McGovern Medical School (D.S., X.J., M.F.), and School of Public Health (B.Y., E.B., M.F.), The University of Texas Health Science Center at Houston; Institute for Stroke and Dementia Research (S.T., M.D.), Klinikum der Universität München, Ludwig-Maximilians-Universität LMU, Munich, Germany; Johns Hopkins University School of Medicine (R.F.G.), Baltimore, MD; The University of Mississippi Medical Center (T.H.M.), Jackson; German Center for Neurodegenerative Diseases (DZNE, Munich) (M.D.); and Munich Cluster for Systems Neurology (SyNergy) (S.T., M.D.), Germany.

Objective: To identify promising blood-based biomarkers and novel etiologic pathways of disease risk, we applied an untargeted serum metabolomics profiling in a community-based prospective study of ischemic stroke (IS).

Methods: In 3,904 men and women from the Atherosclerosis Risk In Communities study, Cox proportional hazard models were used to estimate the association of incident IS with the standardized level of 245 fasting serum metabolites individually, adjusting for age, sex, race, field center, batch, diabetes, hypertension, current smoking status, body mass index, and estimated glomerular filtration rate. Validation of results was carried out in an independent sample of 114 IS cases and 112 healthy controls. Read More

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http://dx.doi.org/10.1212/WNL.0000000000007279DOI Listing
April 2019
5 Reads

Antithrombotic therapy in patients undergoing transcatheter aortic valve implantation.

Heart 2019 Mar 13. Epub 2019 Mar 13.

Department of Cardiology, St Antonius Hospital, Nieuwegein, The Netherlands.

This review provides a comprehensive overview of the available data on antithrombotic therapy after transcatheter aortic valve implantation (TAVI). In the absence of large randomised clinical trials, clinical practice is leaning towards evidence reported in other populations. Due to the greater risk of major bleeding associated with oral anticoagulation using a vitamin-K antagonist (VKA), antiplatelet therapy (APT) may be considered as the first-line treatment of patients undergoing TAVI. Read More

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http://dx.doi.org/10.1136/heartjnl-2018-314313DOI Listing
March 2019
1 Read

Recurrent Acute Ischemic Stroke Associated with Dolichoectatic Aneurysm of the Internal Carotid Artery : A Case Report.

World Neurosurg 2019 Mar 8. Epub 2019 Mar 8.

Department of Neurosurgery, Fukuoka University Chikushi Hospital, Chikushino-city, Japan.

Background: Cranial artery dolichoectasia (CADE) is characterized by dilated, elongated, and tortuous cranial arteries. Dolichoectasia and dolichoectatic aneurysm-particularly of the internal carotid arteries (ICAs)-is rare, but can lead to stroke. We report a case of suspected recurrent acute cerebral infarction associated and dolichoectatic aneurysm of the left ICA combined with right dolichoectatic aneurysm, vertebrobasilar dolichoectasia, and atrial fibrillation. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.02.153DOI Listing
March 2019
1 Read

[Patent foramen ovale closure: how to choose the right device for the right patient].

G Ital Cardiol (Rome) 2019 Mar;20(3):9-16

Interventistica Cardiologica Strutturale, Dipartimento Cardio-Toraco-Vascolare, AOU Careggi, Firenze.

Percutaneous patent foramen ovale (PFO) closure is an intervention aimed to prevent cardioembolic stroke. It recently proved to be superior to antiplatelet therapy in preventing recurrent strokes in a well-selected population of patients with a previous cryptogenic cerebral ischemic event. A large part of the clinical advantage of PFO transcatheter therapy derives from the very high efficacy and safety of the maneuver. Read More

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http://dx.doi.org/10.1714/3121.31036DOI Listing
March 2019
1 Read

Low triglyceride to high-density lipoprotein cholesterol ratio predicts hemorrhagic transformation in large atherosclerotic infarction of acute ischemic stroke.

Aging (Albany NY) 2019 Mar;11(5):1589-1601

Department of Neurology, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, China.

The ratio of triglyceride (TG) to high-density lipoprotein cholesterol (HDL-C) is an objective approach to predicting poor outcomes in acute ischemic stroke (AIS). The impact of TG/HDL-C on hemorrhagic transformation (HT) after AIS remains unknown. The aim of this study was to explore the accurate effect of TG/HDL-C on HT after AIS. Read More

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http://dx.doi.org/10.18632/aging.101859DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6428094PMC
March 2019
1 Read
6.432 Impact Factor

Is lipoprotein(a) a risk factor for ischemic stroke and venous thromboembolism?

Clin Res Cardiol Suppl 2019 Apr;14(Suppl 1):28-32

Institute of Clinical Chemistry, University and University Hospital of Zurich, Raemistraße 100, 8091, Zurich, Switzerland.

The structural similarity with plasminogen as well as thrombogenic and atherogenic in vitro functions raise the question if lipoprotein(a) (Lp(a)) is a risk factor for venous thromboembolism (VTE) and ischemic stroke. Numerous case-control and prospective studies using different cut-off values to define high Lp(a) generated conflicting evidence for both VTE and ischemic stroke. Several meta-analyses demonstrated independent associations of elevated Lp(a) with a history of VTE or ischemic stroke. Read More

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http://dx.doi.org/10.1007/s11789-019-00101-8DOI Listing
April 2019
1 Read

Atrial fibrillation and stroke: a practical guide.

Pract Neurol 2019 Mar 2. Epub 2019 Mar 2.

Stroke Research Centre, University College London Queen Square Institute of Neurology, London, UK

Neurologists and stroke physicians will be familiar with atrial fibrillation as a major cause of ischaemic stroke, and the role of anticoagulation in preventing cardioembolic stroke. However, making decisions about anticoagulation for individual patients remains a difficult area of clinical practice, balancing the serious risk of ischaemic stroke against that of major bleeding, particularly intracranial haemorrhage. Atrial fibrillation management requires interdisciplinary collaboration with colleagues in cardiology and haematology. Read More

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http://dx.doi.org/10.1136/practneurol-2018-002089DOI Listing
March 2019
10 Reads

Cardioembolic Sources in Patients With Small Single Subcortical Infarcts.

Neurologist 2019 Mar;24(2):56-58

Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL.

Transthoracic echocardiogram (TTE) is widely used as part of the work-up for ischemic stroke. However, the added utility of TTE in the management of small single subcortical infarcts (SSSI) has not been extensively evaluated. Therefore, we aimed to determine the frequency of high-risk and medium-risk cardioembolic sources diagnosed by TTE in SSSI patients, and whether the findings altered clinical management. Read More

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http://dx.doi.org/10.1097/NRL.0000000000000224DOI Listing
March 2019
3 Reads

[Clinical characteristics of oldest-old patients with ischemic stroke].

Rinsho Shinkeigaku 2019 Mar 28;59(3):125-132. Epub 2019 Feb 28.

Department of Neurology, Graduate School of Medical Sciences, Kumamoto University.

We divided acute ischemic stroke patients into an oldest old group (≥90 years, n = 414) and an elderly group (75-89 years, n = 1,927), and compared the clinical characteristics between the two groups. Female sex, early admission, severe stroke on admission, atrial fibrillation, and cardioembolic stoke were significantly more frequent in the oldest-old group. On the other hand, risk factors associated with atherosclerosis were less frequent in the oldest-old group. Read More

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https://www.jstage.jst.go.jp/article/clinicalneurol/advpub/0
Publisher Site
http://dx.doi.org/10.5692/clinicalneurol.cn-001262DOI Listing
March 2019
7 Reads

Characterisation of acute ischemic stroke in patients with left ventricular thrombi after myocardial infarction.

J Thromb Thrombolysis 2019 Feb 25. Epub 2019 Feb 25.

Division of Neurology, Department of Medicine, National University Health System, Singapore, Singapore.

Acute ischemic stroke (AIS) is a feared complication in post-acute myocardial infarction (AMI) patients who develop left ventricular (LV) thrombus. There is limited data available on the incidence of stroke in this population, and characterisation of stroke subtypes has not been previously reported. Our study aims to evaluate the incidence of AIS in post-AMI patients with LV thrombus and to characterise the pattern of stroke subtypes. Read More

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http://dx.doi.org/10.1007/s11239-019-01829-6DOI Listing
February 2019
2 Reads

Serum magnesium and calcium levels in relation to ischemic stroke: Mendelian randomization study.

Neurology 2019 Feb 25;92(9):e944-e950. Epub 2019 Jan 25.

From the Unit of Cardiovascular and Nutritional Epidemiology (S.C.L.), Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden; Stroke Research Group, Department of Clinical Neurosciences (M.T., H.S.M.), MRC Biostatistics Unit (S.B.), and Department of Public Health and Primary Care (S.B.), University of Cambridge, UK; Department of Cerebrovascular Diseases (G.B.B.), Fondazione IRCCS-Istituto Neurologico Carlo Besta, Milano, Italy; Department of Clinical Pathology and Genetics (C.J.), Institute of Biomedicine, Sahlgrenska Academy at University of Gothenburg; and Department of Surgical Sciences (K.M.), Uppsala University, Sweden.

Objective: To determine whether serum magnesium and calcium concentrations are causally associated with ischemic stroke or any of its subtypes using the mendelian randomization approach.

Methods: Analyses were conducted using summary statistics data for 13 single-nucleotide polymorphisms robustly associated with serum magnesium (n = 6) or serum calcium (n = 7) concentrations. The corresponding data for ischemic stroke were obtained from the MEGASTROKE consortium (34,217 cases and 404,630 noncases). Read More

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http://dx.doi.org/10.1212/WNL.0000000000007001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6404465PMC
February 2019

Amino Acid Biosignature in Plasma among Ischemic Stroke Subtypes.

Biomed Res Int 2019 20;2019:8480468. Epub 2019 Jan 20.

Department of Biochemistry and Immunology, Federal University of Minas Gerais, Belo Horizonte-MG, Brazil.

Ischemic stroke is a neurovascular disorder caused by reduced or blockage of blood flow to the brain, which may permanently affect motor and cognitive abilities. The diagnostic of stroke is performed using imaging technologies, clinical evaluation, and neuropsychological protocols, but no blood test is available yet. In this work, we analyzed amino acid concentrations in blood plasma from poststroke patients in order to identify differences that could characterize the stroke etiology. Read More

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https://www.hindawi.com/journals/bmri/2019/8480468/
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http://dx.doi.org/10.1155/2019/8480468DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360633PMC
January 2019
5 Reads

Focal Hypoperfusion in Acute Ischemic Stroke Perfusion CT: Clinical and Radiologic Predictors and Accuracy for Infarct Prediction.

AJNR Am J Neuroradiol 2019 Mar 21;40(3):483-489. Epub 2019 Feb 21.

From the Neurology Service (O.B., D.L., P.M.), Department of Clinical Neurosciences.

Background And Purpose: Perfusion CT may improve the diagnostic performance of noncontrast CT in acute ischemic stroke. We assessed predictors of focal hypoperfusion in acute ischemic stroke and perfusion CT performance in predicting infarction on follow-up imaging.

Materials And Methods: Patients from the Acute STroke Registry and Analysis of Lausanne data base with acute ischemic stroke and perfusion CT were included. Read More

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http://dx.doi.org/10.3174/ajnr.A5984DOI Listing

Relative effects of LDL-C on ischemic stroke and coronary disease: A Mendelian randomization study.

Neurology 2019 Mar 20;92(11):e1176-e1187. Epub 2019 Feb 20.

From the Clinical Trial Service Unit and Epidemiological Studies Unit (E.V.-M., S.P., R.C., T.S., J.C.H.) and MRC Population Health Research Unit (S.P.), Nuffield Department of Population Health, University of Oxford, UK; and Departments of Neurology and Public Health Sciences (B.B.W.), University of Virginia School of Medicine, Charlottesville, VA.

Objective: To examine the causal relevance of lifelong differences in low-density lipoprotein cholesterol (LDL-C) for ischemic stroke (IS) relative to that for coronary heart disease (CHD) using a Mendelian randomization approach.

Methods: We undertook a 2-sample Mendelian randomization, based on summary data, to estimate the causal relevance of LDL-C for risk of IS and CHD. Information from 62 independent genetic variants with genome-wide significant effects on LDL-C levels was used to estimate the causal effects of LDL-C for IS and IS subtypes (based on 12,389 IS cases from METASTROKE) and for CHD (based on 60,801 cases from CARDIoGRAMplusC4D). Read More

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http://dx.doi.org/10.1212/WNL.0000000000007091DOI Listing

Is isolated hand weakness associated with subtypes of stroke?

Ideggyogy Sz 2019 01;72(1-2):59-63

Rumeli University, İstanbul, Turkey.

Background And Purpose: Isolated hand weakness is an uncommon condition in stroke patients. It is frequently confused with peripheral nerve system (PNS) pathologies; misdiagnosis may delay identification of the etiology and treatment of stroke. Herein, we aimed to underline the necessity of keeping the diagnosis of stroke in mind in case of patients with isolated hand weakness and to assess the etiology of stroke. Read More

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http://dx.doi.org/10.18071/https://doi.org/10.18071/isz.72.0059DOI Listing
January 2019

Homocysteine and small vessel stroke: A mendelian randomization analysis.

Ann Neurol 2019 Apr 11;85(4):495-501. Epub 2019 Mar 11.

Stroke Research Group, Department of Clinical Neurosciences, University of Cambridge, Cambridge, United Kingdom.

Objective: Trials of B vitamin therapy to lower blood total homocysteine (tHcy) levels for prevention of stroke are inconclusive. Secondary analyses of trial data and epidemiological studies suggest that tHcy levels may be particularly associated with small vessel stroke (SVS). We assessed whether circulating tHcy and B vitamin levels are selectively associated with SVS, but not other stroke subtypes, using Mendelian randomization. Read More

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http://dx.doi.org/10.1002/ana.25440DOI Listing

Comparison of prasugrel and clopidogrel in patients with non-cardioembolic ischaemic stroke: a phase 3, randomised, non-inferiority trial (PRASTRO-I).

Lancet Neurol 2019 Mar 12;18(3):238-247. Epub 2019 Feb 12.

Waseda University Faculty of Science and Engineering, Tokyo, Japan.

Background: The effect of prasugrel in terms of the prevention of recurrence of ischaemic stroke is unknown. We investigated the non-inferiority of prasugrel to clopidogrel for prevention of ischaemic stroke, myocardial infarction, and death from other vascular causes in Japanese patients with non-cardioembolic stroke.

Methods: In this phase 3 randomised, double-blind, non-inferiority trial, patients aged 20-74 years who had had a non-cardioembolic stroke in the previous 1-26 weeks were recruited from 224 hospitals in Japan. Read More

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http://dx.doi.org/10.1016/S1474-4422(18)30449-6DOI Listing
March 2019
6 Reads

No Causal Effect of Telomere Length on Ischemic Stroke and Its Subtypes: A Mendelian Randomization Study.

Cells 2019 Feb 14;8(2). Epub 2019 Feb 14.

Beijing Key Laboratory of Clinical Epidemiology, School of Public Health, Capital Medical University, Beijing 100069, China.

Background: Epidemiological studies observing inconsistent associations of telomere length (TL) with ischemic stroke (IS) are susceptible to bias according to reverse causation and residual confounding. We aimed to assess the causal association between TL, IS, and the subtypes of IS, including large artery stroke (LAS), small vessel stroke (SVS), and cardioembolic stroke (CES) by performing a series of two-sample Mendelian randomization (MR) approaches.

Methods: Seven single nucleotide polymorphisms (SNPs) were involved as candidate instrumental variables (IVs), summarized from a genome-wide meta-analysis including 37,684 participants of European descent. Read More

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http://dx.doi.org/10.3390/cells8020159DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6407010PMC
February 2019
3 Reads

Bioinformatic gene analysis for potential biomarkers and therapeutic targets of atrial fibrillation-related stroke.

J Transl Med 2019 Feb 13;17(1):45. Epub 2019 Feb 13.

Department of Cardio-Vascular Surgery, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, 510120, China.

Background: Atrial fibrillation (AF) is one of the most prevalent sustained arrhythmias, however, epidemiological data may understate its actual prevalence. Meanwhile, AF is considered to be a major cause of ischemic strokes due to irregular heart-rhythm, coexisting chronic vascular inflammation, and renal insufficiency, and blood stasis. We studied co-expressed genes to understand relationships between atrial fibrillation (AF) and stroke and reveal potential biomarkers and therapeutic targets of AF-related stroke. Read More

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http://dx.doi.org/10.1186/s12967-019-1790-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6375208PMC
February 2019
1 Read

Chagas disease, cardioembolic ischemic stroke, INR control and bleeding.

Arq Neuropsiquiatr 2019 Jan;77(1):65

Dr DY Patil University, Pune, India.

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http://dx.doi.org/10.1590/0004-282X20180152DOI Listing
January 2019

The Acute Stroke or Transient Ischemic Attack Treated with Ticagrelor and Aspirin for Prevention of Stroke and Death (THALES) trial: Rationale and design.

Int J Stroke 2019 Feb 12:1747493019830307. Epub 2019 Feb 12.

7 Department of Neurology, Beijing Tiantan Hospital, Beijing, China.

Rationale: In patients with acute cerebral ischemia, the rate of stroke, myocardial infarction, or death during 90 days was reported to be non-significantly lower with ticagrelor compared with aspirin, with no increase in major hemorrhage. Dual antiplatelet therapy may be more effective in this setting.

Aim: To investigate whether ticagrelor combined with aspirin are superior to aspirin alone in preventing stroke or death in patients with non-severe, non-cardioembolic ischemic stroke or high-risk transient ischemic attack. Read More

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http://dx.doi.org/10.1177/1747493019830307DOI Listing
February 2019
2 Reads

Association and interaction of genetic variants with occurrence of ischemic stroke among Brazilian patients.

Gene 2019 May 8;695:84-91. Epub 2019 Feb 8.

University of Region of Joinville, UNIVILLE, Joinville Stroke Biobank, Joinville, Brazil.

Ischemic Stroke (IS) is a severe and complex disorder of high morbidity and mortality rates associated with clinical, environmental, and genetic predisposing factors. Despite previous studies have associated genetic variants to stroke, inconsistent results from different populations pointed to the genetic heterogeneity for IS. Therefore, we may hypothesize that an interaction effect among genetic variants could contribute to IS occurrence rather than genetic variants independently. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03781119193010
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http://dx.doi.org/10.1016/j.gene.2019.01.041DOI Listing
May 2019
2 Reads

Stroke aetiological classification reliability and effect on trial sample size: systematic review, meta-analysis and statistical modelling.

Trials 2019 Feb 8;20(1):107. Epub 2019 Feb 8.

Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK.

Background: Inter-observer variability in stroke aetiological classification may have an effect on trial power and estimation of treatment effect. We modelled the effect of misclassification on required sample size in a hypothetical cardioembolic (CE) stroke trial.

Methods: We performed a systematic review to quantify the reliability (inter-observer variability) of various stroke aetiological classification systems. Read More

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https://trialsjournal.biomedcentral.com/articles/10.1186/s13
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http://dx.doi.org/10.1186/s13063-019-3222-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368715PMC
February 2019
3 Reads

Estimation of Acute Infarct Volume with Reference Maps: A Simple Visual Tool for Decision Making in Thrombectomy Cases.

J Stroke 2019 Jan 31;21(1):69-77. Epub 2019 Jan 31.

Department of Neurology, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea.

Background And Purpose: Thrombectomy within 24 hours can improve outcomes in selected patients with a clinical-infarct mismatch. We devised an easy-to-use visual estimation tool that allows infarct volume estimation in centers with limited resources.

Methods: We identified 1,031 patients with cardioembolic or large-artery atherosclerosis infarction on diffusion-weighted images (DWIs) obtained before recanalization therapy and within 24 hours of onset, and occlusion of the internal carotid or middle cerebral artery. Read More

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http://dx.doi.org/10.5853/jos.2018.03202DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372899PMC
January 2019
6 Reads

The Impact of Left Atrium Appendage Morphology on Stroke Risk Assessment in Atrial Fibrillation: A Computational Fluid Dynamics Study.

Front Physiol 2018 22;9:1938. Epub 2019 Jan 22.

DEI, University of Bologna, Bologna, Italy.

Atrial fibrillation (AF) carries out a 5-fold increase in stroke risk, related to embolization of thrombi clotting in left atrium (LA). Left atrial appendage (LAA) is the site with the highest blood stasis which causes thrombus formation. About 90 % of the intracardiac thrombi in patients with cardioembolic events originally develop in the LAA. Read More

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http://dx.doi.org/10.3389/fphys.2018.01938DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6349592PMC
January 2019

The Relationship between Diffusion-Weighted Magnetic Resonance Imaging Lesions and 24-Hour Rhythm Holter Findings in Patients with Cryptogenic Stroke.

Medicina (Kaunas) 2019 Feb 4;55(2). Epub 2019 Feb 4.

Department of Cardiology, School of Medicine, Trakya University, 22030 Edirne, Turkey.

Background And Objectives: Cranial magnetic resonance imaging findings of patients considered to be cryptogenic stroke may be useful in determining the clinical and prognostic significance of arrhythmias, such as atrial premature beats and atrial run attacks, that are frequently encountered in rhythm Holter analysis. This study was conducted to investigate the relationship between short atrial runs and frequent premature atrial contractions detected in Holter monitors and infarct distributions in cranial magnetic resonance imaging of patients diagnosed with cryptogenic stroke.

Materials And Methods: We enrolled the patients with acute ischemic stroke whose etiology were undetermined. Read More

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http://www.mdpi.com/1010-660X/55/2/38
Publisher Site
http://dx.doi.org/10.3390/medicina55020038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6409892PMC
February 2019
7 Reads