2,321 results match your criteria Cardioembolic Stroke


No Causal Effect of Telomere Length on Ischemic Stroke and Its Subtypes: A Mendelian Randomization Study.

Cells 2019 Feb 14;8(2). Epub 2019 Feb 14.

Beijing Key Laboratory of Clinical Epidemiology, School of Public Health, Capital Medical University, Beijing 100069, China.

Background: Epidemiological studies observing inconsistent associations of telomere length (TL) with ischemic stroke (IS) are susceptible to bias according to reverse causation and residual confounding. We aimed to assess the causal association between TL, IS, and the subtypes of IS, including large artery stroke (LAS), small vessel stroke (SVS), and cardioembolic stroke (CES) by performing a series of two-sample Mendelian randomization (MR) approaches.

Methods: Seven single nucleotide polymorphisms (SNPs) were involved as candidate instrumental variables (IVs), summarized from a genome-wide meta-analysis including 37,684 participants of European descent. Read More

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http://dx.doi.org/10.3390/cells8020159DOI Listing
February 2019

Bioinformatic gene analysis for potential biomarkers and therapeutic targets of atrial fibrillation-related stroke.

J Transl Med 2019 Feb 13;17(1):45. Epub 2019 Feb 13.

Department of Cardio-Vascular Surgery, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, 510120, China.

Background: Atrial fibrillation (AF) is one of the most prevalent sustained arrhythmias, however, epidemiological data may understate its actual prevalence. Meanwhile, AF is considered to be a major cause of ischemic strokes due to irregular heart-rhythm, coexisting chronic vascular inflammation, and renal insufficiency, and blood stasis. We studied co-expressed genes to understand relationships between atrial fibrillation (AF) and stroke and reveal potential biomarkers and therapeutic targets of AF-related stroke. Read More

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http://dx.doi.org/10.1186/s12967-019-1790-xDOI Listing
February 2019
1 Read

Chagas disease, cardioembolic ischemic stroke, INR control and bleeding.

Arq Neuropsiquiatr 2019 Jan;77(1):65

Dr DY Patil University, Pune, India.

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http://dx.doi.org/10.1590/0004-282X20180152DOI Listing
January 2019

The Acute Stroke or Transient Ischemic Attack Treated with Ticagrelor and Aspirin for Prevention of Stroke and Death (THALES) trial: Rationale and design.

Int J Stroke 2019 Feb 12:1747493019830307. Epub 2019 Feb 12.

7 Department of Neurology, Beijing Tiantan Hospital, Beijing, China.

Rationale: In patients with acute cerebral ischemia, the rate of stroke, myocardial infarction, or death during 90 days was reported to be non-significantly lower with ticagrelor compared with aspirin, with no increase in major hemorrhage. Dual antiplatelet therapy may be more effective in this setting.

Aim: To investigate whether ticagrelor combined with aspirin are superior to aspirin alone in preventing stroke or death in patients with non-severe, non-cardioembolic ischemic stroke or high-risk transient ischemic attack. Read More

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http://dx.doi.org/10.1177/1747493019830307DOI Listing
February 2019
1 Read

Association and interaction of genetic variants with occurrence of ischemic stroke among Brazilian patients.

Gene 2019 Feb 8;695:84-91. Epub 2019 Feb 8.

University of Region of Joinville, UNIVILLE, Joinville Stroke Biobank, Joinville, Brazil.

Ischemic Stroke (IS) is a severe and complex disorder of high morbidity and mortality rates associated with clinical, environmental, and genetic predisposing factors. Despite previous studies have associated genetic variants to stroke, inconsistent results from different populations pointed to the genetic heterogeneity for IS. Therefore, we may hypothesize that an interaction effect among genetic variants could contribute to IS occurrence rather than genetic variants independently. Read More

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http://dx.doi.org/10.1016/j.gene.2019.01.041DOI Listing
February 2019

Stroke aetiological classification reliability and effect on trial sample size: systematic review, meta-analysis and statistical modelling.

Trials 2019 Feb 8;20(1):107. Epub 2019 Feb 8.

Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK.

Background: Inter-observer variability in stroke aetiological classification may have an effect on trial power and estimation of treatment effect. We modelled the effect of misclassification on required sample size in a hypothetical cardioembolic (CE) stroke trial.

Methods: We performed a systematic review to quantify the reliability (inter-observer variability) of various stroke aetiological classification systems. Read More

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http://dx.doi.org/10.1186/s13063-019-3222-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368715PMC
February 2019

Estimation of Acute Infarct Volume with Reference Maps: A Simple Visual Tool for Decision Making in Thrombectomy Cases.

J Stroke 2019 Jan 31;21(1):69-77. Epub 2019 Jan 31.

Department of Neurology, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea.

Background And Purpose: Thrombectomy within 24 hours can improve outcomes in selected patients with a clinical-infarct mismatch. We devised an easy-to-use visual estimation tool that allows infarct volume estimation in centers with limited resources.

Methods: We identified 1,031 patients with cardioembolic or large-artery atherosclerosis infarction on diffusion-weighted images (DWIs) obtained before recanalization therapy and within 24 hours of onset, and occlusion of the internal carotid or middle cerebral artery. Read More

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http://dx.doi.org/10.5853/jos.2018.03202DOI Listing
January 2019

The Impact of Left Atrium Appendage Morphology on Stroke Risk Assessment in Atrial Fibrillation: A Computational Fluid Dynamics Study.

Front Physiol 2018 22;9:1938. Epub 2019 Jan 22.

DEI, University of Bologna, Bologna, Italy.

Atrial fibrillation (AF) carries out a 5-fold increase in stroke risk, related to embolization of thrombi clotting in left atrium (LA). Left atrial appendage (LAA) is the site with the highest blood stasis which causes thrombus formation. About 90 % of the intracardiac thrombi in patients with cardioembolic events originally develop in the LAA. Read More

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http://dx.doi.org/10.3389/fphys.2018.01938DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6349592PMC
January 2019

The Relationship between Diffusion-Weighted Magnetic Resonance Imaging Lesions and 24-Hour Rhythm Holter Findings in Patients with Cryptogenic Stroke.

Medicina (Kaunas) 2019 Feb 4;55(2). Epub 2019 Feb 4.

Department of Cardiology, School of Medicine, Trakya University, 22030 Edirne, Turkey.

Background And Objectives: Cranial magnetic resonance imaging findings of patients considered to be cryptogenic stroke may be useful in determining the clinical and prognostic significance of arrhythmias, such as atrial premature beats and atrial run attacks, that are frequently encountered in rhythm Holter analysis. This study was conducted to investigate the relationship between short atrial runs and frequent premature atrial contractions detected in Holter monitors and infarct distributions in cranial magnetic resonance imaging of patients diagnosed with cryptogenic stroke.

Materials And Methods: We enrolled the patients with acute ischemic stroke whose etiology were undetermined. Read More

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http://www.mdpi.com/1010-660X/55/2/38
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http://dx.doi.org/10.3390/medicina55020038DOI Listing
February 2019
3 Reads

Risk Factors for Nonconvulsive Status Epilepticus after Stroke.

Eur Neurol 2019 Feb 4;80(5-6):256-260. Epub 2019 Feb 4.

Department of Cerebrovascular Medicine, National Cerebral and Cardiovascular Center, Suita, Osaka, Japan.

Background: Status epilepticus (SE) sometimes occurs after stroke. SE is classified as convulsive SE (CSE) and nonconvulsive SE (NCSE). Clinical characteristics, outcomes, mortality, and recurrences of post-stroke NCSE are yet to be clarified. Read More

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http://dx.doi.org/10.1159/000496512DOI Listing
February 2019
1 Read

Update on Bayés' syndrome: the association between an interatrial block and supraventricular arrhythmias.

Expert Rev Cardiovasc Ther 2019 Feb 4:1-11. Epub 2019 Feb 4.

a Department of Cardiology , Instituto Cardiovascular de Buenos Aires , Buenos Aires , Argentina.

Introduction: The past few years have given rise to extensive research on an interatrial block and its clinical relevance, mainly its association with supraventricular arrhythmias. In 2015, the authors of this article reviewed the Bayes syndrome for the first time and after three years there has been so much evidence accumulated that it seems reasonable to rewrite an update, based fundamentally on the new findings. Focused on its relationship with cardioembolic strokes, today efforts are being targeted at understanding its pathophysiology, its diagnosis, and its prognostic implications, in order to learn if it should be treated. Read More

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http://dx.doi.org/10.1080/14779072.2019.1577137DOI Listing
February 2019
2 Reads

The different clinical value of susceptibility vessel sign in acute ischemic stroke patients under different interventional therapy: A systematic review and meta-analysis.

J Clin Neurosci 2019 Jan 31. Epub 2019 Jan 31.

Department of Neurology, The First Affiliated Hospital of ChongQing Medical University, Chongqing 400016, China; Chongqing Key Laboratory of Neurobiology, Chongqing, China. Electronic address:

Acute ischemic stroke (AIS) subtype, one of the most important factors for selecting therapeutic strategies, is difficult to be accurately diagnosed at admission sometimes. The magnetic susceptibility effect of deoxygenated hemoglobin in red thrombi appeared as hypointense signals in magnetic resonance imaging (MRI) scans. The prognostic value of susceptibility vessel sign (SVS) for stroke subtype, recanalization and outcomes in AIS patients will be comprehensively determined in the present study. Read More

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http://dx.doi.org/10.1016/j.jocn.2019.01.002DOI Listing
January 2019
1 Read

Radiological features and outcomes of essential thrombocythemia-related stroke.

J Neurol Sci 2019 Jan 22;398:135-137. Epub 2019 Jan 22.

Department of Neurology, Chung-Ang University Hospital, Chung-Ang University College of Medicine, Seoul, Republic of Korea.

Background: Essential thrombocythemia (ET) is known to be associated with an increased vascular event, but the stroke patterns and prognosis have not been studied.

Methods: Between January 2013 and December 2017, acute ischemic stroke patients with ET who were admitted to two tertiary hospital stroke centers in Seoul, Korea were included. We retrospectively reviewed their clinical, laboratory and imaging data. Read More

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http://dx.doi.org/10.1016/j.jns.2019.01.035DOI Listing
January 2019
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Timing of Anticoagulation in Atrial Fibrillation Status Post Cardioembolic Stroke.

J Pharm Pract 2019 Jan 31:897190019825577. Epub 2019 Jan 31.

2 Pharmacy Practice Department, Harrison School of Pharmacy, Auburn University, Auburn, AL, USA.

Background:: Anticoagulation is the mainstay of secondary stroke prevention in patients with atrial fibrillation; however, few studies have assessed the optimal timing for initiation of anticoagulation post cardioembolic stroke. In the 2 weeks following an acute cardioembolic stroke, the risk of recurrent stroke is as high as 8%, but this risk must be balanced against the risk of hemorrhagic transformation with early initiation of anticoagulation.

Purpose:: This study described the time to initiation of anticoagulation and evaluated the in-hospital incidence of hemorrhagic and ischemic complications in 106 patients with atrial fibrillation post an acute cardioembolic stroke. Read More

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http://dx.doi.org/10.1177/0897190019825577DOI Listing
January 2019
5 Reads

Adherence to Guidelines at a Stroke Prevention Clinic: A Follow-up Study.

Can J Neurol Sci 2019 Jan;46(1):57-63

1Faculty of Medicine,McGill University,Montreal,Quebec,Canada.

Background: In 2010, we published our stroke prevention clinic's performance as compared to Canadian stroke prevention guidelines. We now compare our clinic's adherence with guidelines to our previous results, following the implementation of an electronic documentation form.

Methods: All new patients referred to our clinic (McGill University Health Center) for recent transient ischemic attack (TIA) or ischemic stroke between 2014 and 2017 were included. Read More

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https://www.cambridge.org/core/product/identifier/S031716711
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http://dx.doi.org/10.1017/cjn.2018.352DOI Listing
January 2019
4 Reads

Risk Assessment of Stroke in Patients with Atrial Fibrillation: Current Shortcomings and Future Directions.

Cardiovasc Drugs Ther 2019 Jan 25. Epub 2019 Jan 25.

Section of Cardiology, Department of Medicine, Baylor College of Medicine, Houston, TX, USA.

Atrial fibrillation is a well-known risk factor for cardioembolic stroke; a number of risk stratification scoring systems have been developed to help differentiate which patients would stand to benefit from anticoagulation. However, these scoring systems cannot be utilized in patients whose atrial fibrillation has not been diagnosed. As implantable cardiac monitors become more prevalent, it becomes possible to identify occult, subclinical atrial fibrillation. Read More

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http://dx.doi.org/10.1007/s10557-018-06849-7DOI Listing
January 2019
1 Read

FDG atrial uptake is associated with an increased prevalence of stroke in patients with atrial fibrillation.

Eur J Nucl Med Mol Imaging 2019 Jan 25. Epub 2019 Jan 25.

Nuclear Medicine Department, Bichat-Claude Bernard Hospital, AP-HP, Paris, France.

Purpose: Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia and is associated with an increased risk of stroke. Indeed, silent AF is frequently identified in unexplained ischemic stroke. F-FDG-PET/CT is a powerful tool for assessing myocardial metabolic shift and inflammation, both potentially at stake in AF. Read More

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http://dx.doi.org/10.1007/s00259-019-4274-6DOI Listing
January 2019

Role of real time-three dimensional transesophageal echocardiography in left atrial appendage closure with LACBES devices.

Exp Ther Med 2019 Feb 12;17(2):1456-1462. Epub 2018 Dec 12.

Department of Cardiology, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200011, P.R. China.

Catheter-based left atrial appendage closure (LAAC) has recently become an innovative strategy for preventing embolic events in patients with nonvalvular atrial fibrillation (AF). There is limited information on optimal sizing for LAAC with the recently developed LACBES device. The aim of the present study was to assess the role of real time-three dimensional transesophageal echocardiography (RT-3D TEE) for LACBES device selection during LAAC. Read More

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http://dx.doi.org/10.3892/etm.2018.7086DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327486PMC
February 2019
1 Read

Associations of echocardiographic features with stroke in those without atrial fibrillation.

Neurology 2019 Jan 23. Epub 2019 Jan 23.

From the Department of Neurology (M.C.J., M.L., R.F.G.), The Johns Hopkins University School of Medicine, Baltimore, MD; and the Department of Cardiology (S.N.), The University of Pennsylvania Perelman School of Medicine, Philadelphia.

Objective: To determine the associations between transthoracic echocardiogram (TTE) cardiac structure/function measures and cardioembolic stroke (CES) and new-onset atrial fibrillation (AF) in patients without known AF.

Methods: Inpatients at a single institution (2013-2015) with imaging-confirmed ischemic stroke, no AF, and TTE within the 1st week were included. TTE structure/function variables were abstracted. Read More

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http://dx.doi.org/10.1212/WNL.0000000000007002DOI Listing
January 2019
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Succinate links atrial dysfunction and cardioembolic stroke.

Neurology 2019 Feb 23;92(8):e802-e810. Epub 2019 Jan 23.

From the Departments of Neurology and Anesthesiology/Critical Care Medicine (S.E.N.), Johns Hopkins Hospital, Baltimore, MD; Center for Genomic Medicine (Z.A., Z.W., W.T.K.) and Division of Neurocritical Care and Emergency Neurology, Department of Neurology (Z.A., Z.W., W.T.K.), Massachusetts General Hospital, Harvard Medical School; and Division of Cardiovascular Medicine (R.E.G.), Beth Israel Deaconess Hospital, Boston, MA.

Objective: To determine whether altered metabolic profiles represent a link between atrial dysfunction and cardioembolic (CE) stroke, and thus whether underlying dysfunctional atrial substrate may contribute to thromboembolism risk in CE stroke.

Methods: A total of 144 metabolites were measured using liquid chromatography-tandem mass spectrometry in plasma samples collected within 9 hours of stroke onset in 367 acute stroke patients. Stroke subtype was assigned using the Causative Classification of Stroke System, and CE stroke (n = 181) was compared to non-CE stroke (n = 186). Read More

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http://dx.doi.org/10.1212/WNL.0000000000006957DOI Listing
February 2019
1 Read

Vitamin B deficiency and hyperhomocysteinaemia in outpatients with stroke or transient ischaemic attack: a cohort study at an academic medical centre.

BMJ Open 2019 Jan 21;9(1):e026564. Epub 2019 Jan 21.

Division of Clinical Pharmacology, Department of Medicine, Western University, London, Ontario, Canada.

Objective: We sought to assess the current magnitude of the opportunity for secondary stroke prevention with B vitamins.

Design: A cohort study.

Setting: The Urgent TIA (Transient Ischaemic Attack) Clinic at an academic medical centre. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-026564DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347886PMC
January 2019
1 Read

Serum Troponin Level in Acute Ischemic Stroke Identifies Patients with Visceral Infarcts.

J Stroke Cerebrovasc Dis 2019 Jan 18. Epub 2019 Jan 18.

Department of Neurology, the Warren Alpert Medical School of Brown University, Providence, Rhode Island. Electronic address:

Background And Purpose: Patients with ischemic stroke of cardioembolic origin are at risk of visceral (renal or splenic) infarction. We hypothesized that serum troponin level at time of ischemic stroke would be associated with presence of visceral infarction.

Methods: Data were abstracted from a single center prospective stroke database over 18 months and included all patients with ischemic stroke who underwent contrast-enhanced computerized tomography (CT) of the abdomen and pelvis for clinical purposes within 1 year of stroke. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10523057193000
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http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2019.01.004DOI Listing
January 2019
5 Reads

Bridging Therapy Versus Direct Mechanical Thrombectomy in Patients with Acute Ischemic Stroke due to Middle Cerebral Artery Occlusion: A Clinical-Histological Analysis of Retrieved Thrombi.

Cell Transplant 2019 Jan 18:963689718823206. Epub 2019 Jan 18.

1 Department of Neurology, Shanghai Tenth People's Hospital, Tongji University, Shanghai, China.

Mechanical thrombectomy (MT) is effective in managing patients with acute ischemic stroke (AIS) caused by large-vessel occlusions and allows for valuable histological analysis of thrombi. However, whether bridging therapy (pretreatment with intravenous thrombolysis before MT) provides additional benefits in patients with middle cerebral artery (MCA) occlusion remains unclear. Therefore, this study aimed to compare the effects of direct MT and bridging therapy, and to elucidate the correlation between thrombus composition and stroke subtypes. Read More

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http://dx.doi.org/10.1177/0963689718823206DOI Listing
January 2019
2 Reads

Warfarin loading dose guided by pharmacogenetics is effective and safe in cardioembolic stroke patients - a randomized, prospective study.

Pharmacogenomics J 2019 Jan 16. Epub 2019 Jan 16.

Department of Neurology, 2nd Faculty of Medicine, Charles University, Motol University Hospital, Prague, Czech Republic.

Warfarin treatment is commonly started with a fixed loading dose that might be associated with an increased risk of bleeding. An individual maintenance dose can then be estimated based on a pharmacogenetic algorithm. Starting treatment with the estimated dose implies a longer time to reach the therapeutic range. Read More

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http://dx.doi.org/10.1038/s41397-019-0066-4DOI Listing
January 2019
1 Read

Association of Embolic Sources With Cause-Specific Functional Outcomes Among Adults With Cryptogenic Stroke.

JAMA Netw Open 2018 Sep 7;1(5):e182953. Epub 2018 Sep 7.

Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

Importance: It is unknown whether poststroke outcome varies between different potential causes in patients with cryptogenic stroke.

Objective: To investigate whether functional outcome differs according to potential embolic sources after cryptogenic stroke.

Design, Setting, And Participants: This multicenter, hospital-based, prospective stroke registry cohort study investigated potential embolic sources on admission and assessed 3-month outcome in patients with ischemic stroke hospitalized at 7 stroke centers in the Fukuoka Stroke Registry. Read More

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http://dx.doi.org/10.1001/jamanetworkopen.2018.2953DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6324510PMC
September 2018
8 Reads

Relationship between normalized distributional pattern and functional outcome in patients with acute cardiogenic cerebral embolism.

PLoS One 2019 15;14(1):e0210709. Epub 2019 Jan 15.

Department of Neurosurgery, Osaka University Graduate School of Medicine, Osaka, Japan.

This study aimed to elucidate spatial characteristics for magnetic resonance imaging (MRI) of cardiogenic cerebral embolism, to determine imaging biomarkers predicting patient outcome and cerebral herniation in cardioembolic stroke. This retrospective study assessed 90 patients with cardiogenic cerebral embolism. All images from MRI were normalized using a voxel-based symptom lesion mapping technique. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0210709PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333406PMC
January 2019
5 Reads

Anticoagulation in patients with Embolic Stroke of Unknown Source.

Authors:
J David Spence

Int J Stroke 2019 Jan 15:1747493019826363. Epub 2019 Jan 15.

Stroke Prevention & Atherosclerosis Research Centre, Robarts Research Institute, Western University, London, Canada.

When warfarin was the mainstay of anticoagulation for the prevention of cardioembolic stroke, the paradigm was essentially "we mustn't anticoagulate anyone unless we prove that the stroke was cardioembolic." Now that direct-acting oral anticoagulants are available, the paradigm should change. The risk of stroke is highest soon after the initial event, particularly in patients with more than one infarction. Read More

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http://dx.doi.org/10.1177/1747493019826363DOI Listing
January 2019
2 Reads

Phenotypic ASCOD characterisations of ischaemic stroke in the young at an urban tertiary care centre.

Stroke Vasc Neurol 2018 Dec 30;3(4):209-214. Epub 2018 Jul 30.

Department of Stroke and Neurocritical Care, University of Vermont College of Medicine, Burlington, Vermont, USA.

Background And Purpose: Stroke in young individuals is a serious public health burden. This study aimed to characterise the various phenotypes of ischaemic stroke in a young urban population (≤50 years old) using the ASCOD classification system, which assigns a score to five stroke categories: atherosclerosis, small vessel disease (SVD), cardioembolism, other and dissection. Within each category, a numerical score represents the degree of causality attributed to the stroke. Read More

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http://dx.doi.org/10.1136/svn-2017-000139DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6312072PMC
December 2018

Subclinical atrial fibrillation - what is the risk of stroke?

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 2019 Jan 10. Epub 2019 Jan 10.

Department of Internal Medicine I - Cardiology, University Hospital Olomouc, Czech Republic.

Atrial fibrillation is the most common arrhythmia and as such, it has become a significant public health issue due to its impact on patient morbidity and mortality. The prevalence of atrial fibrillation (AF) almost doubled in the last decade, being currently 2% in unselected patient populations. Its occurrence varies with age (present in almost 20% of octogenarians) and concomitant diseases. Read More

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http://dx.doi.org/10.5507/bp.2018.083DOI Listing
January 2019
3 Reads

Lambl's Excrescences and Stroke: A Scoping Study.

Int J Clin Res Trials 2018 20;3(2). Epub 2018 Oct 20.

Divisions of Cardiovascular Disease, and Endocrinology, Department of Internal Medicine, State University of New York, Downstate Medical Center, Brooklyn, New York, 11203, USA.

Stroke / Cerebrovascular accident (CVA) is a leading cause of morbidity and mortality in the world. Ischemic stroke accounts for 87% of the cases, 14-30% of which is attributed to cardio-embolic stroke. Lambl's excrescences (LE) were first described in 1856 by a Bohemian physician- VilemDusanLambl and is considered a rare cause of cardioembolic stroke subtype. Read More

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http://dx.doi.org/10.15344/2456-8007/2018/127DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322692PMC
October 2018
2 Reads

Genetically Determined Levels of Circulating Cytokines and Risk of Stroke.

Circulation 2019 Jan;139(2):256-268

Institute for Stroke and Dementia Research, University Hospital of Ludwig-Maximilians-University, Munich, Germany (M.K.G., J.B., R.M., M.D.).

Background: Cytokines and growth factors have been implicated in the initiation and propagation of vascular disease. Observational studies have shown associations of their circulating levels with stroke. Our objective was to explore whether genetically determined circulating levels of cytokines and growth factors are associated with stroke and its etiologic subtypes by conducting a 2-sample Mendelian randomization (MR) study. Read More

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http://dx.doi.org/10.1161/CIRCULATIONAHA.118.035905DOI Listing
January 2019
2 Reads

Oral anticoagulation and left atrial appendage closure: a new strategy for recurrent cardioembolic stroke.

Eur J Neurol 2018 Dec 26. Epub 2018 Dec 26.

Departamento de Medicina, Facultad de Medicina, Universidad de Alcalá (IRYCIS), Madrid.

Background And Purpose: There are no recommendations regarding how to treat cardioembolic recurrent strokes when patients are well anticoagulated. We evaluated the safety and efficacy of combining oral anticoagulation (OAC) with percutaneous left atrial appendage closure (LAAC) in patients with well-anticoagulated atrial fibrillation (AF) with recurrent strokes.

Methods: In an explorative, prospective, observational study, LAAC was performed in patients with AF with at least two ischaemic strokes in the previous year, despite good anticoagulation using the Amplatzer Cardiac Plug (St Jude Medical, St Paul, MN, USA) or Amulet Abbot device (Abbot Vascular, Santa Clara, CA, USA). Read More

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http://dx.doi.org/10.1111/ene.13894DOI Listing
December 2018

Can Admission BNP Level Predict Outcome After Intravenous Thrombolysis in Acute Ischemic Stroke?

Neurologist 2019 Jan;24(1):6-9

Department of Neurology, The Ohio State University, Columbus, OH.

Objective: Our study aimed to determine the prognostic value of elevated Brain Natriuretic Peptide (BNP) among patients who received intravenous thrombolysis (IVT) in acute ischemic stroke (AIS).

Background: The elevation in BNP level is correlated with infarct size, poststroke mortality, and CHADS2 score. Currently, there is a lack of validated biomarker to predict the outcome in patients with acute ischemic stroke, and there is a complex interaction amongst multiple variables. Read More

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http://dx.doi.org/10.1097/NRL.0000000000000214DOI Listing
January 2019
1 Read

[Interrelation of endothelial dysfunction and parameters of erythrocyte membrane oxygenation in patients with atrial fibrillation, after cardioembolic stroke.]

Adv Gerontol 2018 ;31(3):379-386

Samara state medical University, 89, Chapaevskaya str., Samara, 443099, Russian Federation; e-mail:

The aim of our work was to study the relationship between endothelial dysfunction (ED) and erythrocyte membrane oxygenation parameters in patients over 60 years of age with atrial fibrillation (AF) within a year after a cardioembolic stroke. In the period from 01 January 2014 to 30 January 2015. the authors performed a prospective observational study in which, after scrinia by the random number generated 4 groups of patients after stroke: group 1 (n=65) with newly diagnosed AF (ndAF), group 2 (n=65) - paroxysmal form of AF group 3 (n=65) is a persistent form of AF and group 4 (n=65) with permanent form of AF. Read More

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January 2018

Atrial fibrillation genetic risk differentiates cardioembolic stroke from other stroke subtypes.

Neurol Genet 2018 Dec 3;4(6):e293. Epub 2018 Dec 3.

Department of Genetics (S.L.P., P.I.W.d. B.), University Medical Center Utrecht, Utrecht University, The Netherlands; P.I.W.d.B. is now with Computational Genomics, Vertex Pharmaceuticals, Boston, MA; Li Ka Shing Centre for Health Information and Discovery (S.L.P.), The Big Data Institute, University of Oxford, United Kingdom; Program in Medical and Population Genetics (S.L.P., L.-C.W., S.H.C., J.R., P.T.E., S.A.L., C.D.A.), Broad Institute, Cambridge, MA; Cardiovascular Research Center (L.-C.W., P.T.E., S.A.L.), Center for Genomic Medicine (J.R., C.D.A.), J.P. Kistler Stroke Research Center (J.R., C.D.A.), and Cardiac Arrhythmia Service (P.T.E., S.A.L.), Massachusetts General Hospital, Boston; Department of Medicine (P.F.M., B.D.M.), Program for Personalized and Genomic Medicine, University of Maryland School of Medicine, Baltimore; National Heart, Lung, and Blood Institute's and Boston University's Framingham Heart Study (L.T., E.J.B.); Department of Biostatistics (L.T.) and Department of Epidemiology (E.J.B.), Boston University School of Public Health, MA; Geriatrics Research and Education Clinical Center (B.D.M.), Baltimore Veterans Administration Medical Center, MD; Cardiology Preventive Medicine Sections (E.J.B.), Evans Department of Medicine, Boston University School of Medicine; Department of Neurology (S.J.K.), University of Maryland School of Medicine; and Department of Neurology (S.J.K.), Veterans Affairs Medical Center, Baltimore, MD.

Objective: We sought to assess whether genetic risk factors for atrial fibrillation (AF) can explain cardioembolic stroke risk.

Methods: We evaluated genetic correlations between a previous genetic study of AF and AF in the presence of cardioembolic stroke using genome-wide genotypes from the Stroke Genetics Network (N = 3,190 AF cases, 3,000 cardioembolic stroke cases, and 28,026 referents). We tested whether a previously validated AF polygenic risk score (PRS) associated with cardioembolic and other stroke subtypes after accounting for AF clinical risk factors. Read More

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http://dx.doi.org/10.1212/NXG.0000000000000293DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6283455PMC
December 2018

Real-world adherence to oral anticoagulants in atrial fibrillation patients: a study protocol for a systematic review and meta-analysis.

BMJ Open 2018 Dec 19;8(12):e025102. Epub 2018 Dec 19.

Health Services Research Unit, Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunidad Valenciana (FISABIO), Valencia, Spain.

Introduction: Atrial fibrillation (AF) is one of the leading causes of cerebrovascular mortality and morbidity. Oral anticoagulants (OACs) have been shown to reduce the incidence of cardioembolic stroke in patients with AF, adherence to treatment being an essential element for their effectiveness. Since the release of the first non-vitamin K antagonist oral anticoagulant, several observational studies have been carried out to estimate OAC adherence in the real world using pharmacy claim databases or AF registers. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-025102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6303591PMC
December 2018

Iron Status and Risk of Stroke.

Stroke 2018 Dec;49(12):2815-2821

From the Department of Biostatistics and Epidemiology (D.G., G.M., I.T., A.D.), Imperial College London, United Kingdom.

Background and Purpose- Both iron deficiency and excess have been associated with stroke risk in observational studies. However, such associations may be attributable to confounding from environmental factors. This study uses the Mendelian randomization technique to overcome these limitations by investigating the association between genetic variants related to iron status and stroke risk. Read More

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http://dx.doi.org/10.1161/STROKEAHA.118.022701DOI Listing
December 2018
1 Read

Pediatric cardioembolic stroke in midaortic syndrome.

Arq Neuropsiquiatr 2018 Nov;76(11):800-801

University of Kentucky, Department of Neurology, Lexington, KY, USA.

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http://dx.doi.org/10.1590/0004-282X20180117DOI Listing
November 2018
1 Read

[Non-cardioembolic ischemic stroke hypertensive patients, a therapeutic hope. Reply].

Rev Neurol 2019 Jan;68(1):44-45

Centro Nacional de Investigaciones Cientificas (CNIC), Playa, La Habana, Cuba.

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January 2019
2 Reads

[Non-cardioembolic ischemic stroke hypertensive patients, a therapeutic hope].

Rev Neurol 2019 Jan;68(1):44

Universidad de Ciencias Medicas de La Habana, La Habana, Cuba.

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January 2019
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Uptake and radiological findings of screening cerebral magnetic resonance scans in patients with hereditary haemorrhagic telangiectasia.

Intractable Rare Dis Res 2018 Nov;7(4):236-244

NHLI Cardiovascular Sciences, Imperial College London, London, UK.

Hereditary haemorrhagic telangiectasia (HHT) results in arteriovenous malformations (AVMs), most commonly in the lungs, liver and brain. Discussion of cerebral vascular malformations is an important element of patient management. The current study objectives were to examine uptake and results of screening cerebral magnetic resonance (MR) scans, excluding symptomatic patients requiring neurological investigations. Read More

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http://dx.doi.org/10.5582/irdr.2018.01103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6290842PMC
November 2018
1 Read

Abnormally high risk of stroke in Brugada syndrome.

J Cardiovasc Med (Hagerstown) 2019 Feb;20(2):59-65

Heart Rhythm Management Center, Postgraduate program in Cardiac Electrophysiology and Pacing.

Background: The present study sought to evaluate the incidence of cerebrovascular events in a large cohort of patients with Brugada syndrome (BrS) analysing possible predictors, clinical characteristics and prognosis of cardioembolic events secondary to atrial fibrillation.

Methods: A total of 671 consecutive patients (age 42.1 ± 17. Read More

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http://dx.doi.org/10.2459/JCM.0000000000000723DOI Listing
February 2019
10 Reads

Body Mass Index and Risks of Incident Ischemic Stroke Subtypes: The Japan Public Health Center-Based Prospective (JPHC) Study.

J Epidemiol 2018 Dec 15. Epub 2018 Dec 15.

Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center.

Background: The association of body mass index (BMI) with risks of ischemic stroke subtypes have not been established.

Methods: Cumulative average BMI was calculated using self-reported body weight and height obtained from baseline (Cohort I in 1990, and Cohort II from 1993-1994) and 5- and 10-year questionnaire surveys of Japan Public Health Center-based prospective (JPHC) study. A total of 42,343 men and 46,413 women aged 40-69 years were followed-up for the incidence of lacunar, large-artery occlusive, and cardioembolic strokes. Read More

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http://dx.doi.org/10.2188/jea.JE20170298DOI Listing
December 2018
1 Read

[Cardiomegalia gigante].

Gac Med Mex 2018 ;154(6):727-728

Universidad de Castilla-La Mancha, Hospital General Universitario de Albacete; Centro de Salud de Villanueva de la Jara. Castilla-La Mancha, España.

Eighty-year old woman with a medical history of arterial hypertension, rheumatic valvular heart disease with mitral and aortic valve replacement, chronic atrial fibrillation and congestive heart failure dependent on domiciliary chronic oxygen for 17 daily hours. The reason for arrival to the hospital was a stroke of cardioembolic etiology. Read More

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http://dx.doi.org/10.24875/GMM.18004398DOI Listing
January 2018
1 Read

First attempt recanalization with ADAPT: rate, predictors, and outcome.

J Neurointerv Surg 2018 Dec 7. Epub 2018 Dec 7.

Department of Neurosurgery, Medical University of South Carolina, Charleston, South Carolina, USA.

Introduction: The rate of first-attempt recanalization (FAR) with the newer-generation thrombectomy devices, and more specifically with aspiration devices, is not well known. Moreover, the effect of FAR on outcomes after mechanical thrombectomy is not properly understood.

Objective: To report the rate of FAR using a direct aspiration first pass technique (ADAPT), investigate the association between FAR and outcomes, and identify the predictors of FAR. Read More

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http://dx.doi.org/10.1136/neurintsurg-2018-014294DOI Listing
December 2018
2 Reads

Features of Patients Aged 80 Years or Older with Embolic Stroke of Undetermined Source.

J Stroke Cerebrovasc Dis 2019 Feb 24;28(2):251-255. Epub 2018 Oct 24.

Division of Neurology, Department of Internal Medicine, Tokai University School of Medicine, Isehara, Japan.

Background: Embolic stroke of undetermined source has not been thoroughly investigated in older patients. In this study, we investigated the features of this condition in patients greater than or equal to 80 years of age.

Methods: All patients with acute ischemic stroke in our hospital underwent diffusion-weighted imaging, magnetic resonance angiography, T2-weighted imaging, and fluid-attenuated inversion recovery sequence imaging. Read More

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http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2018.09.039DOI Listing
February 2019
1 Read

Atrial cardiopathy in patients with embolic strokes of unknown source and other stroke etiologies.

Neurology 2019 Jan 5;92(4):e288-e294. Epub 2018 Dec 5.

From the Department of Medicine (Neurology) (S.J.), Queens' University, Kingston; Departments of Medicine (Neurology) (R.R., A.P.) and Medicine (Cardiology) (A.D.J., A.W.), Toronto Western Hospital/University Health Network, and Dalla Lana School of Public Health (R.N.), University of Toronto; and Centre for Urban Health Solutions (R.N.), Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, Canada.

Objective: To investigate the prevalence and clinical determinants of atrial cardiopathy in patients with embolic stroke of unknown source (ESUS) and compare with other established stroke etiologies.

Methods: In a cross-sectional study of 846 consecutive patients with ischemic stroke, we compared the prevalence of atrial cardiopathy (defined by p-wave terminal force in V1 >5,000 µV·ms or severe left atrial enlargement) between ESUS patients and patients with large artery atherosclerosis (LAA) and small vessel disease (SVD) strokes. Baseline characteristics were also compared between ESUS and cardioembolic (CE) patients. Read More

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http://dx.doi.org/10.1212/WNL.0000000000006748DOI Listing
January 2019
2 Reads

Differences in Ischemic Anterior and Posterior Circulation Strokes: A Clinico-Radiological and Outcome Analysis.

J Stroke Cerebrovasc Dis 2019 Mar 28;28(3):710-718. Epub 2018 Nov 28.

Stroke Center/Neurology Service of the Lausanne University Hospital, Switzerland.

Background: There are limited data comparing posterior (PC) and anterior (AC) circulation acute ischemic strokes (AIS). We aimed to identify specific features of PC and AC strokes regarding clinical, etiological, radiological, and outcome factors.

Methods: Patients from the Acute STroke Registry and Analysis of Lausanne, a prospective cohort of consecutive AIS, from years 2003 to 2008 were included. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10523057183065
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http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2018.11.016DOI Listing
March 2019
11 Reads

Left-Sided Atrial Septal Pouch as a Risk Factor of Cryptogenic Stroke: A Systematic Review and Meta-Analysis.

Cerebrovasc Dis 2018 5;46(5-6):223-229. Epub 2018 Dec 5.

HEART, Heart Embryology and Anatomy Research Team, Department of Anatomy, Jagiellonian University Medical College, Cracow, Poland.

Background: Despite some evidence of left-sided septal pouch (LSSP) involvement in the pathogenesis of cardioembolic stroke, the question of LSSP clinical significance still remains unsolved. In this study, we aimed to determine the association between the LSSP presence and cryptogenic stroke using meta-analytical approach.

Methods: We performed a systematic review of electronic databases for studies that compared the presence of LSSP in subjects with cryptogenic stroke and non-stroke control. Read More

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http://dx.doi.org/10.1159/000495573DOI Listing
December 2018
3 Reads