2,439 results match your criteria Cardioembolic Stroke


[Cardiomegalia gigante].

Gac Med Mex 2018 ;154(6):727-728

Universidad de Castilla-La Mancha, Hospital General Universitario de Albacete; Centro de Salud de Villanueva de la Jara. Castilla-La Mancha, España.

Eighty-year old woman with a medical history of arterial hypertension, rheumatic valvular heart disease with mitral and aortic valve replacement, chronic atrial fibrillation and congestive heart failure dependent on domiciliary chronic oxygen for 17 daily hours. The reason for arrival to the hospital was a stroke of cardioembolic etiology. Read More

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January 2018

First attempt recanalization with ADAPT: rate, predictors, and outcome.

J Neurointerv Surg 2018 Dec 7. Epub 2018 Dec 7.

Department of Neurosurgery, Medical University of South Carolina, Charleston, South Carolina, USA.

Introduction: The rate of first-attempt recanalization (FAR) with the newer-generation thrombectomy devices, and more specifically with aspiration devices, is not well known. Moreover, the effect of FAR on outcomes after mechanical thrombectomy is not properly understood.

Objective: To report the rate of FAR using a direct aspiration first pass technique (ADAPT), investigate the association between FAR and outcomes, and identify the predictors of FAR. Read More

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December 2018

Features of Patients Aged 80 Years or Older with Embolic Stroke of Undetermined Source.

J Stroke Cerebrovasc Dis 2018 Oct 24. Epub 2018 Oct 24.

Division of Neurology, Department of Internal Medicine, Tokai University School of Medicine, Isehara, Japan.

Background: Embolic stroke of undetermined source has not been thoroughly investigated in older patients. In this study, we investigated the features of this condition in patients greater than or equal to 80 years of age.

Methods: All patients with acute ischemic stroke in our hospital underwent diffusion-weighted imaging, magnetic resonance angiography, T2-weighted imaging, and fluid-attenuated inversion recovery sequence imaging. Read More

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October 2018

Atrial cardiopathy in patients with embolic strokes of unknown source and other stroke etiologies.

Neurology 2018 Dec 5. Epub 2018 Dec 5.

From the Department of Medicine (Neurology) (S.J.), Queens' University, Kingston; Departments of Medicine (Neurology) (R.R., A.P.) and Medicine (Cardiology) (A.D.J., A.W.), Toronto Western Hospital/University Health Network, and Dalla Lana School of Public Health (R.N.), University of Toronto; and Centre for Urban Health Solutions (R.N.), Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, Canada.

Objective: To investigate the prevalence and clinical determinants of atrial cardiopathy in patients with embolic stroke of unknown source (ESUS) and compare with other established stroke etiologies.

Methods: In a cross-sectional study of 846 consecutive patients with ischemic stroke, we compared the prevalence of atrial cardiopathy (defined by p-wave terminal force in V1 >5,000 µV·ms or severe left atrial enlargement) between ESUS patients and patients with large artery atherosclerosis (LAA) and small vessel disease (SVD) strokes. Baseline characteristics were also compared between ESUS and cardioembolic (CE) patients. Read More

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December 2018
1 Read

Use of oral anticoagulants in complex clinical situations with atrial fibrillation.

Med Clin (Barc) 2018 Jun;150 Suppl 1:8-24

Servicio de Medicina Interna, Hospital Universitario de La Princesa, Madrid, España. Electronic address:

The present article provides an update on anticoagulant treatment in patients with atrial fibrillation in distinct clinical scenarios requiring particular considerations, such as ischaemic heart disease, electrical cardioversion, pulmonary vein ablation, the presence of valvular disease with or without prosthetic valves, and renal insufficiency, as well as old age and frailty. In patients with non-valvular atrial fibrillation, the presence of renal insufficiency increases both thrombotic and haemorrhagic risk. In mild and moderate stages, direct-acting anticoagulants confer a greater benefit than warfarin, although they usually require dose adjustment. Read More

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June 2018
1 Read

Differences in Ischemic Anterior and Posterior Circulation Strokes: A Clinico-Radiological and Outcome Analysis.

J Stroke Cerebrovasc Dis 2018 Nov 27. Epub 2018 Nov 27.

Stroke Center/Neurology Service of the Lausanne University Hospital, Switzerland.

Background: There are limited data comparing posterior (PC) and anterior (AC) circulation acute ischemic strokes (AIS). We aimed to identify specific features of PC and AC strokes regarding clinical, etiological, radiological, and outcome factors.

Methods: Patients from the Acute STroke Registry and Analysis of Lausanne, a prospective cohort of consecutive AIS, from years 2003 to 2008 were included. Read More

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November 2018
3 Reads

Left-Sided Atrial Septal Pouch as a Risk Factor of Cryptogenic Stroke: A Systematic Review and Meta-Analysis.

Cerebrovasc Dis 2018 Dec 5;46(5-6):223-229. Epub 2018 Dec 5.

Background: Despite some evidence of left-sided septal pouch (LSSP) involvement in the pathogenesis of cardioembolic stroke, the question of LSSP clinical significance still remains unsolved. In this study, we aimed to determine the association between the LSSP presence and cryptogenic stroke using meta-analytical approach.

Methods: We performed a systematic review of electronic databases for studies that compared the presence of LSSP in subjects with cryptogenic stroke and non-stroke control. Read More

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December 2018
2 Reads

Imaging Review of Common and Rare Causes of Stroke in Children.

Top Magn Reson Imaging 2018 Dec;27(6):463-477

Department of Pediatrics, Division of Child Neurology, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA.

Vascular injury is increasingly recognized as an important cause of mortality and morbidity in children (29 days to 18 years of age). Since vascular brain injury in children appears to be less common than in adults, the index of suspicion for vascular brain injury is usually lower. In this review article, we describe frequent and rare conditions underlying pediatric stroke including cardioembolic, viral, autoimmune, post-traumatic, and genetic etiologies. Read More

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December 2018
1 Read

Effect of Continued Administration of Low-dose Aspirin for Intraoperative Bleeding Control in Gastric Endoscopic Submucosal Dissection.

Digestion 2018 Dec 4:1-8. Epub 2018 Dec 4.

Background: The use of antithrombotic agents for the prevention of cerebro-cardioembolic events has increased, and recent guidelines have recommended the continued administration of low-dose aspirin (LDA) during endoscopic procedures with a high risk of bleeding. However, the influence of LDA on intraoperative bleeding control status during Endoscopic submucosal dissection (ESD) remains unclear.

Methods: We examined 293 consecutive patients who underwent ESD for gastric cancers between January 2014 and February 2018. Read More

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December 2018
3 Reads

Prevalence of hypertension and prehypertension and its associated cardioembolic risk factors; a population based cross-sectional study in Alkharj, Saudi Arabia.

BMC Public Health 2018 Nov 29;18(1):1327. Epub 2018 Nov 29.

College of Public Health and Health Informatics, King Saud Bin AbdulAziz University for Health Sciences, Mail Code 2350, P.O. Box 3660, Riyadh, 11481, Saudi Arabia.

Background: Hypertension and prehypertension pose significant public-health and clinical challenges for both economically developed and developing nations. Prevalence of these conditions are frequently underreported because of its often-silent nature. Population-based studies that explore the occurrence and correlates of these conditions are scarce in Saudi Arabia. Read More

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November 2018

Relationship between the Angle of the Posterior Inferior Cerebellar Artery and Cardioembolic Stroke.

J Stroke Cerebrovasc Dis 2018 Nov 24. Epub 2018 Nov 24.

Department of Neurology, Korea University Ansan Hospital, Korea University College of Medicine, Ansan, Republic of Korea. Electronic address:

Background: In patients with unilateral posterior inferior cerebellar artery (PICA) territory infarction, the absence of relevant vessel stenosis may make it difficult to determine the etiology of the infarction. The incidence of cardioembolic (CE) infarction and the factors associated with infarction in such patients remains largely unknown. We hypothesized that the PICA angle would affect the flow direction of embolic sources. Read More

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November 2018

Primary Thrombectomy Versus Combined Mechanical Thrombectomy and Intravenous Thrombolysis in Large Vessel Occlusion Acute Ischemic Stroke.

J Stroke Cerebrovasc Dis 2018 Nov 22. Epub 2018 Nov 22.

Neurology Department, Centro Hospitalar de Vila Nova de Gaia/Espinho, Portugal; Stroke Unit, Centro Hospitalar de Vila Nova de Gaia/Espinho, Portugal.

Mechanical thrombectomy (MT) in combination with intravenous thrombolysis (IVT) is the standard of care for patients with acute ischemic stroke with anterior circulation large vessel occlusion. The particular benefit of IVT in these patients is unknown. We performed a retrospective analysis of patients submitted to MT at our center between January 2015 and June 2017. Read More

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November 2018
2 Reads

Role of Transesophageal Echocardiography in Patients with Ischemic Stroke.

Prog Cardiovasc Dis 2018 Nov 20. Epub 2018 Nov 20.

John Ochsner Heart and Vascular Institute, Ochsner Clinical School-The University of Queensland School of Medicine, New Orleans, LA, United States of America.

Acute ischemic stroke is a condition with considerable mortality and morbidity. When used appropriately, Transesophageal Echocardiography (TEE) can be an incredibly useful tool to identify potential causes of stroke and guide management. The crucial distinction in this modality lies in separating common incidental findings from those likely to have contributed to ischemic stroke. Read More

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November 2018
2 Reads

Complex Left Atrial Appendage Morphology Is an Independent Risk Factor for Cryptogenic Ischemic Stroke.

Front Cardiovasc Med 2018 23;5:131. Epub 2018 Oct 23.

Texas Heart Institute, Houston, TX, United States.

Ischemic strokes pose a significant health burden. However, the etiology of between 20 and 40% of these events remains unknown. Left atrial appendage morphology may influence the occurrence of thromboembolic events. Read More

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October 2018
4 Reads

Frequency of Ischemic Stroke Subtypes Based on Toast Classification at a Tertiary Care Center in Pakistan.

Asian J Neurosurg 2018 Oct-Dec;13(4):984-989

Department of Neurology, Shifa International Hospital, Islamabad, Pakistan.

Background: The purpose of this study was to determine the frequency of ischemic stroke subtypes based on Trial of Org 10172 in Acute Stroke Treatment (TOAST) classification at a tertiary care center in Pakistan.

Materials And Methods: A cross-sectional study was conducted in Stroke Unit of Shifa International Hospital, Islamabad. We included 145 patients who presented to us from November 2015 to February 2016 with radiological confirmed neurological deficits consistent with ischemic stroke. Read More

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November 2018
1 Read

Two-Layered Susceptibility Vessel Sign and High Overestimation Ratio on MRI Are Predictive of Cardioembolic Stroke.

AJNR Am J Neuroradiol 2018 Nov 15. Epub 2018 Nov 15.

Institut National de la Santé et de la Recherche Médicale U894 (C.O., O.N.), Sainte-Anne Hospital, Paris, France.

In a prospective study among patients in the THRombectomie des Artères Cerebrales trial, we analyzed the diagnostic accuracy of 2 imaging biomarkers, the 2-layered susceptibility vessel sign and a high overestimation ratio, obtained on pretreatment brain T2* sequences, to identify cardioembolic stroke etiology (107/260 patients). In combination, these 2 biomarkers, on 1.5T or 3T systems (159 and 101 patients, respectively), demonstrated high specificity (0. Read More

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November 2018

Prestroke Aspirin Use is Associated with Clinical Outcomes in Ischemic Stroke Patients with Atherothrombosis, Small Artery Disease, and Cardioembolic Stroke.

J Atheroscler Thromb 2018 Nov 14. Epub 2018 Nov 14.

Department of Neurology, People's Hospital of Deyang City.

Aim: To evaluate the effect of prestroke aspirin (PA) use on initial stroke severity, early neurologic deterioration (END), stroke recurrence, hemorrhagic transformation (HT), and functional outcome in patients with ischemic stroke (IS).

Methods: This was a prospective, observational, multicenter cohort study. The acute IS patients with atherothrombosis (AT), small artery disease (SAD), or cardioembolic (CE) stroke within 24 hours of symptom onset were identified. Read More

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November 2018
3 Reads

Migraine with visual aura is a risk factor for incident atrial fibrillation: A cohort study.

Neurology 2018 Dec 14;91(24):e2202-e2210. Epub 2018 Nov 14.

From the Department of Neurology (S.S., X.M.A., V.D., T.T.), University of South Carolina, School of Medicine, Columbia; Department of Epidemiology (A.A.), Rollins School of Public Health, Emory University, Atlanta, GA; Department of Medicine (L.Y.C.), University of Minnesota, Minneapolis; Department of Epidemiology and Internal Medicine (E.Z.S.), Wake Forest School of Medicine, Winston-Salem, NC; Division of Cardiology (J.M.), Department of Medicine, Heart and Vascular Institute, University of Pittsburgh, Medical Center, PA; Department of Epidemiology (A.T.M.), Arnold School of Public Health, University of South Carolina, Columbia; Department of Neurology (R.F.G.), Johns Hopkins University School of Medicine, Baltimore, MD; and Department of Epidemiology (W.D.R.), Gilling's School of Public Health, University of North Carolina, Chapel Hill.

Objective: Migraine with visual aura is associated with cardioembolic stroke risk. The aim of this study was to test association between migraine with visual aura and atrial fibrillation (AF), in the Atherosclerosis Risk in Communities study.

Methods: In the Atherosclerosis Risk in Communities study, a longitudinal, community-based cohort study, participants were interviewed for migraine history in 1993-1995 and were followed for incident AF through 2013. Read More

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December 2018
7 Reads

Advances in Stroke Prevention.

Authors:
J David Spence

J Transl Int Med 2018 Sep 9;6(3):105-114. Epub 2018 Oct 9.

Stroke Prevention & Atherosclerosis Research Centre, Robarts Research Institute, Western University, London, Canada.

There have been recent advances in stroke prevention in nutrition, blood pressure control, antiplatelet therapy, anticoagulation, identification of high-risk asymptomatic carotid stenosis, and percutaneous closure of patent foramen ovale. There is evidence that the Mediterranean diet significantly reduces the risk of stroke and that B vitamins lower homocysteine, thus preventing stroke. The benefit of B vitamins to lower homocysteine was masked by harm from cyanocobalamin among study participants with impaired renal function; we should be using methylcobalamin instead of cyanocobalamin. Read More

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September 2018
2 Reads

Validation of overestimation ratio and TL-SVS as imaging biomarker of cardioembolic stroke and time from onset to MRI.

Eur Radiol 2018 Nov 12. Epub 2018 Nov 12.

Department of Neuroradiology, Université Paris-Descartes. INSERM U894, Sainte-Anne Hospital, Paris, France.

Objective: We aimed to determine in the "THRACE" trial, the clinical and MRI technical parameters associated with the two-layered susceptibility vessel sign (TL-SVS) and the overestimation ratio (overR).

Materials And Methods: Patients with pre-treatment brain gradient echo (GRE) sequence and an etiological work-up were identified. Two readers reviewed TL-SVS, i. Read More

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November 2018
4 Reads

Risk Factors for Hemorrhagic and Cardioembolic Complications of Intracerebral Hemorrhage Associated with Anticoagulants.

J Stroke Cerebrovasc Dis 2018 Nov 8. Epub 2018 Nov 8.

Department of Neurosurgery, Maebashi Red Cross Hospital, Maebashi, Gunma, Japan. Electronic address:

Background: Patients with intracerebral hemorrhage taking anticoagulants are increasingly common in Japan due to the aging population. The clinical benefit of restarting anticoagulants is established, but the optimal timing of resumption is controversial. Risk factors for hemorrhagic and cardioembolic events in the acute phase are also unknown. Read More

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November 2018
8 Reads

The Multiple Causes of Stroke in Atrial Fibrillation: Thinking Broadly.

Can J Cardiol 2018 Nov 30;34(11):1503-1511. Epub 2018 Aug 30.

Division of Neurology, Department of Medicine, University of Alberta, Edmonton, Alberta, Canada. Electronic address:

Atrial fibrillation (AF) is numerically the most important risk factor for stroke. It is well established that patients with AF have a 5-fold increased risk of stroke relative to those without and that anticoagulation reduces the risk of stroke by approximately two-thirds. Definitively attributing the mechanism of an individual stroke to AF is more problematic, however. Read More

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November 2018
4 Reads

Large Left Ventricular Thrombus as a Cause of Recurrent Cardioembolic Stroke While on Dabigatran.

CASE (Phila) 2018 Oct 7;2(5):222-224. Epub 2018 Jul 7.

Department of Cardiology, Vidant Medical Center/East Carolina University, Greenville, North Carolina.

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October 2018

Circulating Vitamin K₁ Levels in Relation to Ischemic Stroke and Its Subtypes: A Mendelian Randomization Study.

Nutrients 2018 Oct 25;10(11). Epub 2018 Oct 25.

Stroke Research Group, Department of Clinical Neurosciences, University of Cambridge, Cambridge CB20QQ, UK.

Vitamin K plays a crucial role in blood coagulation, and hypercoagulability has been linked to atherosclerosis-related vascular disease. We used the Mendelian randomization study design to examine whether circulating vitamin K₁ (phylloquinone) levels are associated with ischemic stroke. Four single-nucleotide polymorphisms associated with vitamin K₁ levels were used as instrumental variables. Read More

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October 2018
4 Reads
3.150 Impact Factor

Oral anticoagulation therapy and subsequent risk of venous thromboembolism in atrial fibrillation patients.

Curr Med Res Opin 2018 Oct 26:1-20. Epub 2018 Oct 26.

e Department of Epidemiology , Rollins School of Public Health, Emory University , 1518 Clifton Road NE , Atlanta , Georgia 30322 , USA.

Objective: Oral anticoagulation (OAC) prescribed to AF patients for the prevention of cardioembolic complications likely has the added benefit of preventing venous thromboembolism (VTE). We evaluated, among AF patients who are anticoagulated, whether type of OAC was associated with subsequent VTE risk.

Methods: Non-valvular AF patients prescribed OACs between 2010 and September 2015 were identified via the MarketScan administrative claims databases. Read More

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October 2018
5 Reads

A stroke gene panel for whole-exome sequencing.

Eur J Hum Genet 2018 Oct 24. Epub 2018 Oct 24.

Department of Clinical Sciences Lund, Neurology, Lund University, Lund, Sweden.

Extensive analyses of known monogenic causes of stroke by whole-exome/genome sequencing are technically possible today. We here aimed to compile a comprehensive panel of genes associated with monogenic causes of stroke for use in clinical and research situations. We systematically searched the publically available database Online Mendelian Inheritance in Man, and validated the entries against original peer-reviewed publications in PubMed. Read More

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October 2018
7 Reads

Thrombus Permeability in Admission Computed Tomographic Imaging Indicates Stroke Pathogenesis Based on Thrombus Histology.

Stroke 2018 Nov;49(11):2674-2682

From the Departments of Neuroradiology (M.B., B.F., C.M., S.M., D.H., M.L., C.Z., T.B.-B.), Klinikum rechts der Isar, Technical University of Munich, Germany.

Background and Purpose- Intracranial thrombi can be characterized according to their permeability as measured by contrast agent penetration. Thrombus composition and its associated pathogenesis are important factors affecting treatment and secondary prevention. We aimed to explore the histopathologic factors explaining the heterogeneity of thrombus permeability measures and evaluated potential correlations with stroke pathogenesis. Read More

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November 2018
2 Reads

Cardioembolic Stroke Risk and Recovery After Anticoagulation-Related Intracerebral Hemorrhage.

Stroke 2018 Nov;49(11):2652-2658

Divisions of Neurocritical Care & Emergency Neurology and Vascular Neurology, Department of Neurology, Yale University School of Medicine, New Haven, CT (A.L., G.J.F., L.H.S., K.N.S.).

Background and Purpose- Whether to resume oral anticoagulation treatment after intracerebral hemorrhage (ICH) remains an unresolved question. Previous studies focused primarily on recurrent stroke after ICH. We sought to investigate the association between cardioembolic stroke risk, oral anticoagulation therapy resumption, and functional recovery among ICH survivors in the absence of recurrent stroke. Read More

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November 2018
6 Reads

Genetically Determined FXI (Factor XI) Levels and Risk of Stroke.

Stroke 2018 Nov;49(11):2761-2763

From the Department of Biostatistics and Epidemiology, School of Public Health (D.G., I.T., A.D.), Imperial College London, United Kingdom.

Background and Purpose- FXI (factor XI) is involved in thrombus propagation and stabilization. It is unknown whether lower FXI levels have a protective effect on risk of ischemic stroke (IS) or myocardial infarction. This study investigated the effect of genetically determined FXI levels on risk of IS, myocardial infarction, and intracerebral hemorrhage. Read More

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November 2018
9 Reads

Serum 25-Hydroxyvitamin D Concentrations and Ischemic Stroke and Its Subtypes.

Stroke 2018 Oct;49(10):2508-2511

Stroke Research Group, Department of Clinical Neurosciences, University of Cambridge, United Kingdom (M.T., H.S.M.).

Background and Purpose- Observational studies have reported increased risk of ischemic stroke among individuals with low serum 25-hydroxyvitamin D (S-25OHD) concentrations but uncertainty remains about the causality of this association. We sought to determine whether S-25OHD concentrations are causally associated with ischemic stroke and its subtypes using Mendelian randomization. Methods- We used summary-level data for ischemic stroke (34 217 cases and 404 630 noncases) from the MEGASTROKE consortium. Read More

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October 2018
5.723 Impact Factor

Effects of policosanol in the functional recovery of non-cardioembolic ischemic stroke hypertensive patients.

Rev Neurol 2018 Nov;67(9):331-338

Centro Nacional de Investigaciones Cientificas (CNIC), Playa, La Habana, Cuba.

Introduction: Clinical studies results show that policosanol (20 mg/day) + aspirin therapy had benefits versus placebo + aspirin to patients with recent non-cardioembolic ischemic stroke.

Aim: To analyze the policosanol treatment effects in the hypertensive patients included in two non-cardioembolic ischemic stroke recovery trials.

Patients And Methods: Hypertensive patients with a modified Rankin Scale (mRS) score 2 to 4 were randomized, within 30 days of onset, to policosanol + aspirin or placebo + aspirin, for six months. Read More

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November 2018

Cumulative Effects of LDL Cholesterol and CRP Levels on Recurrent Stroke and TIA.

J Atheroscler Thromb 2018 Oct 15. Epub 2018 Oct 15.

Department of Clinical Neuroscience and Therapeutics, Hiroshima University Graduate School of Biomedical and Health Sciences.

Aims: To investigate the relative contribution of on-treatment low-density lipoprotein (LDL) cholesterol and C-reactive protein (CRP) to the risk of recurrent stroke and transient ischemic attack (TIA) in patients with history of ischemic stroke.

Methods: A total of 1095 patients with non-cardioembolic ischemic stroke were randomized into two groups: control and patients receiving 10 mg of pravastatin per day. After excluding 18 patients who did not have baseline CRP data, the effects of LDL cholesterol and CRP on recurrent stroke and TIA were prospectively assessed in 1077 patients. Read More

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October 2018
4 Reads

Differential MicroRibonucleic Acid Expression in Cardioembolic Stroke.

J Stroke Cerebrovasc Dis 2019 Jan 11;28(1):121-124. Epub 2018 Oct 11.

Department of Neurology, University of Texas Health Science Center, Houston, Texas. Electronic address:

Background: MicroRNAs (miRNA) are a class of small, endogenous (17-25 nucleotide) noncoding ribonucleic acids implicated in the transcriptional and post-transcriptional regulation of gene expression. This study examines stroke-specific miRNA expression in large vessel territory cardioembolic stroke.

Methods: Peripheral blood was collected from controls and ischemic stroke patients 24 hours after stroke onset. Read More

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January 2019
5 Reads

Role of Echocardiography in Assessment of Cardioembolic Sources: a Strong Diagnostic Resource in Patients with Ischemic Stroke.

Curr Cardiol Rep 2018 Oct 11;20(12):136. Epub 2018 Oct 11.

Aurora Cardiovascular Services, Aurora Sinai/Aurora St. Luke's Medical Centers, 2801 W. Kinnickinnic River Parkway, Ste. 880, Milwaukee, WI, 53215, USA.

Purpose Of Review: This review will discuss the most frequent sources of cardiac embolism and the role of echocardiography in these different clinical settings, and, in addition, provide suggestions about the choice between transthoracic (TTE) and transesophageal echocardiography (TEE).

Recent Findings: Stroke is the third leading cause of death in industrial countries, and 15-40% of all ischemic strokes are due to cardioembolism. TTE and TEE are cornerstones in the detection of cardioembolic sources and provide fundamental information about the embolic risk and most suitable treatment of these patients, improving long-term outcomes. Read More

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October 2018
9 Reads

Ischemic stroke in young adults.

Curr Opin Cardiol 2018 Nov;33(6):594-604

Department of Neurology, Baltimore VA Medical Center and University of Maryland School of Medicine, Baltimore, Maryland, USA.

Purpose Of Review: Although the clinical approach to the young adult stroke patient is similar to that of an older adult, several important differences exist. The purpose of this article is to concisely review the epidemiology, pathophysiology, risk factors, clinical manifestations, diagnostic methods and current treatment options for the young adult ischemic stroke patient.

Recent Findings: Evidence clearly indicates that the incidence ischemic stroke in young adults is on the rise. Read More

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November 2018
5 Reads

The role of P2Y receptor in ischemic stroke of atherosclerotic origin.

Cell Mol Life Sci 2018 Oct 9. Epub 2018 Oct 9.

Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.

Atherosclerosis is a chronic and progressive disease of the arterial walls and a leading cause of non-cardioembolic ischemic stroke. P2Y is a well-recognized receptor that is expressed on platelets and is a target of thienopyridine-type antiplatelet drugs. In the last few decades, P2Y receptor inhibitors, such as clopidogrel, have been applied for the secondary prevention of non-cardioembolic ischemic stroke. Read More

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October 2018
2 Reads

High five-year mortality rates of ischemic stroke subtypes: A prospective cohort study in Brazil.

Int J Stroke 2018 Oct 9:1747493018806197. Epub 2018 Oct 9.

6 Neurology Department, Paraná Federal University, Curitiba, Brazil.

Background: Studies regarding long-term outcomes of ischemic stroke subtypes are scarce in low- and middle-income countries. We aimed to measure the five-year prognosis of ischemic stroke subtypes in Joinville, Brazil.

Methods: All first-ever ischemic strokes that occurred in Joinville in 2010 were followed-up for five years. Read More

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October 2018
1 Read

Eosinophilic Granulomatosis with Polyangiitis (EGPA) with an Unusual Manifestation of Mid-Ventricular Obstruction Caused by Endocardial Thrombus.

Am J Case Rep 2018 Oct 8;19:1197-1203. Epub 2018 Oct 8.

Department of Cardiology, Osaka Medical College, Takatsuki, Osaka, Japan.

BACKGROUND Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare systemic vasculitis of unknown cause accompanied by prominent eosinophilia. Intracardiac thrombosis is one of the major cardiac complications in EGPA that may cause thromboembolism. CASE REPORT A 46-year-old male presenting with intermittent chest pain and numbness of the lower extremities was admitted to our center. Read More

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October 2018
7 Reads

Trends in stroke outcomes in the last ten years in a European tertiary hospital.

BMC Neurol 2018 Oct 3;18(1):164. Epub 2018 Oct 3.

Clinical Neurosciences Research Laboratory, Health Research Institute of Santiago de Compostela (IDIS), Santiago de Compostela, Spain.

Background: Studying the impact of demographic changes and progress in the management of stroke patients is necessary in order to organize care structures for the coming years. Consequently, we analyzed the prognostic trends of patients admitted to the Stroke Unit of a tertiary hospital in the last ten years.

Methods: The University Clinical Hospital of Santiago de Compostela is the referral hospital for stroke in a catchment area that accounts for 16. Read More

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October 2018
10 Reads

[Prevention of cardioembolic events after intracranial hemorrhage].

G Ital Cardiol (Rome) 2018 Oct;19(10):542-551

Divisione di Medicina Interna ad Indirizzo Metabolico e Riabilitativo, Dipartimento di Scienze Mediche Traslazionali, Università degli Studi "Federico II", Napoli.

In high thromboembolic risk patients who experienced hemorrhagic stroke, the prevention of cardioembolic events and recurrence of intracranial bleeding should be guaranteed. The consultant cardiologist should carefully identify the most appropriate therapeutic approach for these patients. Among patients with previous hemorrhagic stroke, only few restart oral anticoagulant therapy (OAT) after cerebral bleeding; however, as reported by some registries, it is likely that resuming OAT exerts a favorable effect on the combined outcome of ischemic stroke/systemic embolism/all-cause death. Read More

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October 2018
1 Read

[Cerebral embolism in Duchenne muscular dystrophy after respiratory tract infection - Report of two cases].

Rinsho Shinkeigaku 2018 Oct 29;58(10):642-645. Epub 2018 Sep 29.

Department of Neurology, NHO Toneyama National Hospital.

We report cerebral embolism in 2 patients with Duchenne muscular dystrophy (DMD) after respiratory tract infection. A 31-year-old man (Case 1) was admitted to the hospital because of an upper respiratory tract infection, then suddenly developed left-sided hemiparesis. Transthoracic echocardiography revealed an intracardiac thrombus in the left ventricle, and, under assumption of cardioembolic stroke, oral anticoagulation was initiated. Read More

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October 2018
1 Read

Intracranial Atherosclerosis is the Most Common Stroke Subtype: Ten-year Data from Hyderabad Stroke Registry (India).

Ann Indian Acad Neurol 2018 Jul-Sep;21(3):209-213

Department of Neurology, Nizam's Institute of Medical Sciences, Hyderabad, Telangana, India.

Aim: Limited data regarding stroke subtypes exist from South Asian countries. The aim of the study was to determine the pattern of ischemic stroke subtypes and their associated risk factors, in a 10-year long hospital-based registry in the South Indian city of Hyderabad.

Materials And Methods: The Hyderabad stroke registry systematically collected clinical, radiological, and laboratory data of fully investigated consecutive stroke patients and studied pattern of ischemic stroke subtypes and their risk factor association. Read More

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September 2018
3 Reads

Caseous Calcifications of Mitral Annulus as an Unusual Cause of Cardioembolic Stroke in a 40-Year-Old Man.

Cureus 2018 Jul 20;10(7):e3015. Epub 2018 Jul 20.

Department of Cardiothoracic Surgery, Crozer Chester Medical Center, Upland, USA.

Caseous calcification of mitral annulus (CCMA) is a rare variant of mitral annular calcification. Previously thought to have been a benign condition, CCMA may be a potential source of cardioembolic stroke. We present a case of a 40-year-old man with end-stage renal disease on hemodialysis and hypertension who presented with acute onset of visual blurring and headache and was diagnosed with cardioembolic stroke secondary to CCMA. Read More

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A protocol update for the Selenium Treatment and Chagasic Cardiomyopathy (STCC) trial.

Trials 2018 Sep 19;19(1):507. Epub 2018 Sep 19.

Laboratory of Innovations in Therapies, Education and Bioproducts, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil.

Several studies evaluating clinical forms of chronic Chagas disease show that about one-third of patients present cardiac involvement. Heart failure, sudden death and cardioembolic stroke are the main mechanisms of death in Chagas heart disease. The impact of specific etiologic treatment on the prognosis of patients with chronic Chagas heart disease is very limited regardless of the presence or absence of heart failure. Read More

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September 2018
11 Reads

Predictive Factors for Functional Outcomes After Intravenous Thrombolytic Therapy in Acute Ischemic Stroke.

Clin Appl Thromb Hemost 2018 Sep 13:1076029618796317. Epub 2018 Sep 13.

3 Department of Neurology, Ministry of Health Tepecik Teaching and Research Hospital, İzmir, Turkey.

The objective of our study is to detect the patient group that will most benefit from intravenous (IV) thrombolytic therapy by showing predictive factors of good functional outcomes. The present study covers 88 patients who were admitted to our clinic within the first 4.5 hours from the onset of stroke symptoms, diagnosed with acute ischemic stroke and who received IV thrombolytic therapy between May 2014 and June 2017 as a result of a retrospective analysis of a database prospectively collected. Read More

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September 2018
5 Reads

Mechanical Thrombectomy in Acute Stroke Due to Carotid Occlusion: A Series of 153 Consecutive Patients.

Cerebrovasc Dis 2018 13;46(3-4):132-141. Epub 2018 Sep 13.

Section of Interventional Neuroradiology, Hospital Clínico Universitario Virgen de la Arrixaca, Murcia, Spain.

Background: Strokes due to carotid artery occlusion (CAO) are associated with bad clinical prognosis and poor response to intravenous thrombolysis. Several studies in the past have shown the benefits of mechanical thrombectomy (MT) and compared bridging therapy (BT) and primary MT (PMT) in large vessel occlusions, but only a few studies have focused on the specific population of CAO and their response to endovascular treatment.

Methods: Retrospective review of patients treated at our center between January 2010 and June 2017 that (1) presented with acute ischemic stroke caused by CAO in the first 4. Read More

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September 2018
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Role of platelet α2-adrenoreceptor in biological low response to Clopidogrel for patients with non cardioembolic ischemic stroke or transient ischemic attack.

Am J Transl Res 2018 15;10(8):2712-2721. Epub 2018 Aug 15.

Vascular and Therapeutic Medicine Department, Saint-Etienne University Hospital Center, North Hospital Saint-Etienne F-42055, France.

Background And Purpose: Low biological response to Clopidogrel prescribed after non cardioembolic ischemic stroke or transient ischemic attack (TIA) is a major clinical problem and could explain the recurrence of vascular events. Platelet α2-adrenoreceptors are involved in the high residual platelet reactivity in stable coronary artery disease patients on dual antiplatelet therapy. In the present study we investigated the impact of platelet α2-adrenoreceptors on ADP-induced platelet aggregation and on ADP-induced platelet membrane CD62P (P-selectin) expression, a marker of platelet activation on blood samples from patients hospitalized at the acute phase of a non cardioembolic ischemic stroke or TIA. Read More

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August 2018
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