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Shanghai Kou Qiang Yi Xue 2021 Apr;30(2):156-161

Stomatological Center, Peking University Shenzhen Hospital. Shenzhen 518000, China.

Purpose: To investigate the relationship between oral Candida albicans and flora in children with severe infant caries.

Methods: Forty-two children with severe infant caries (experimental group) and 40 caries-free children (control group) treated in Peking University Shenzhen Hospital from March 2018 to June 2019 were enrolled. The samples of saliva and plaque were collected and cultured. Read More

Arch Oral Biol 2021 Aug 27;128:105171. Epub 2021 May 27.

Marmara University, Faculty of Dentistry, Department of Restorative Dentistry, Istanbul, Turkey.

Objectives: We aimed to determine the aetiologic agent responsible for black staining of permanent dentition using next-generation sequencing and determine the relationship between caries and black stains.

Materials And Methods: A total of 52 systemically healthy patients with black-stained and caries-free (n = 13), black-stained and carious (n = 13), black stain-free and caries-free (n = 13), and black stain-free and carious (n = 13) teeth were enrolled in the study. The International Caries Detection and Assessment System (ICDAS II) was used for caries classification. Read More

Front Microbiol 2021 14;12:630345. Epub 2021 May 14.

Capital Institute of Pediatrics, Beijing, China.

Similar to those in the upper respiratory tract, there are microbes present in the healthy human lower respiratory tract (LRT), including the lungs and bronchus. To evaluate the relationship between LRT microbiome and allergic respiratory diseases in children, we enrolled 68 children who underwent bronchoscopy from January 2018 to December 2018 in the affiliated hospital of the Capital Institute of Pediatrics. Using the total IgE (TIgE) values, children were divided into two groups: allergy sensitivity (AS) group and non-allergy sensitivity (NAS) group. Read More

IDCases 2021 7;24:e01149. Epub 2021 May 7.

Department of Infectious Diseases, University of Florida COM-Jacksonville, 655 8th W 8th Street, Jacksonville, FL, USA.

An 80-year-old patient was admitted for fever, chills, and chest wall pain. He had a past medical history significant for heart failure with a cardiac resynchronization therapy pacemaker implantation. Extensive workup revealed endocarditis of the pacemaker leads and the mitral valve, a rare etiology with an unidentified source in our patient. Read More

Intern Med 2021 May 22. Epub 2021 May 22.

Department of General Internal Medicine, Akashi Medical Center, Japan.

Hemolytic anemia is a rarely occurring manifestation of native valve infective endocarditis. We herein report an afebrile patient with hemolytic anemia caused by Cardiobacterium hominis endocarditis. A 60-year-old Japanese man had a history of aortic root replacement and the gradual onset of general fatigue. Read More

Eur J Intern Med 2021 May 9. Epub 2021 May 9.

Infectious Diseases Unit, Internal Medicine Department, Hospital Puerta de Hierro, Majadahonda, Madrid, Spain.

Background: Infective endocarditis (IE) due to non-HACEK bacilli (Haemophilus species, Actinobacillus, Cardiobacterium, Eikenella, or Kingella) is uncommon and poorly described. The objectives of this study were to describe non-HACEK Gram-Negative Bacilli (GNB) IE cases and compare characteristic of IE produced by Enterobacterales and non-fermenting (NF) GNB.

Methods: From January 2008 to December 2018, 3910 consecutive patients with definitive IE diagnosis, defined with Modified Duke criteria, either clinical or pathological criteria (e. Read More

J Pediatr 2021 May 8. Epub 2021 May 8.

Texas Children's Hospital, Houston, TX; Baylor College of Medicine, Houston, TX.

HACEK organisms (Haemophilus, Aggregatibacter, Cardiobacterium, Eikenella, and Kingella species) are rare causes of endocarditis. HACEK organisms are fastidious and may escape detection by culture techniques, but the use of molecular studies may aid diagnosis. A 10-year review of pediatric HACEK endocarditis cases at Texas Children's Hospital identified 10 patients, with 2 cases recognized by next-generation sequencing, highlighting potential benefits of these assays. Read More

Eur J Clin Microbiol Infect Dis 2021 Apr 14. Epub 2021 Apr 14.

Division of Infection Medicine, Department of Clinical Sciences, Lund, Lund University, BMC B14, SE-221 84, Lund, Sweden.

Infective endocarditis (IE) caused by bacteria within Haemophilus (excluding Haemophilus influenzae), Aggregatibacter, Cardiobacterium, Eikenella and Kingella (HACEK) is rare. This study aimed to describe clinical features of IE caused by HACEK genera in comparison with IE due to other pathogens. Cases of IE due to HACEK were identified through the Swedish Registry of Infective Endocarditis (SRIE). Read More

Ann Clin Microbiol Antimicrob 2021 Feb 27;20(1):14. Epub 2021 Feb 27.

Division of Infectious Diseases, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.

Background: HACEK (Haemophilus spp., Aggregatibacter spp., Cardiobacterium spp. Read More

J Oral Microbiol 2020 Dec 30;13(1):1865690. Epub 2020 Dec 30.

Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Barcelona, Spain.

: The oral cavity harbors an abundant and diverse microbial community (i.e. the microbiome), whose composition and roles in health and disease have been the focus of intense research. Read More

J Infect Chemother 2021 May 2;27(5):747-750. Epub 2021 Jan 2.

Department of Clinical Infectious Diseases, Aichi Medical University Hospital, Nagakute, Aichi, Japan; Department of Infection Control and Prevention, Aichi Medical University Hospital, Nagakute, Aichi, Japan.

We report a case of prosthetic arthritis caused by Cardiobacterium valvarum, which has been exclusively reported to cause intravascular infections. A 81-year-old Japanese female complained prosthetic knee joint pain. Arthrocentesis cultured no pathogen, and surgical replacement of the implant surface was performed. Read More

Cureus 2020 Nov 17;12(11):e11527. Epub 2020 Nov 17.

Cardiology, Mohammed I University/Mohammed VI University Hospital, Oujda, MAR.

Infective endocarditis caused by Acinetobacter (A.) baumannii is a rare but severe complication that affects seriously ill, hospitalized patients undergoing invasive procedures. It is associated with an increased mortality rate than that of endocarditis due to the HACEK group (Haemophilus species, Aggregatibacter actinomycetemcomitans, Cardiobacterium hominis, Eikenella corrodens, Kingella kingae) gram-negative bacteria. Read More

Intern Med 2021 May 15;60(10):1621-1625. Epub 2020 Dec 15.

Division of General Medicine, Department of Comprehensive Medicine 1, Saitama Medical Center, Jichi Medical University, Japan.

Aggregatibacter actinomycetemcomitans, an etiological agent associated with periodontitis, endocarditis, and other infections, has rarely been implicated in spondylitis. A 70-year-old man with aortic valve replacement presented with a 4-month history of lower back pain and was diagnosed with spondylitis. Prolonged incubation of blood cultures and a biopsy yielded A. Read More

J Clin Microbiol 2021 Feb 18;59(3). Epub 2021 Feb 18.

Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, USA

Timely diagnosis of microorganisms in blood cultures is necessary to optimize therapy. Although blood culture media and systems have evolved for decades, the standard interval for incubation prior to being discarded as negative has remained 5 days. Here, we evaluated the optimal incubation time for the BacT/Alert Virtuo blood culture detection system (bioMérieux) using FA Plus (aerobic) and FN Plus (anaerobic) resin culture bottles in routine clinical use. Read More

Acta Cardiol 2020 Nov 4:1-2. Epub 2020 Nov 4.

Cardiovascular Center OLV Aalst, Aalst, Belgium.

Access Microbiol 2019 6;1(9):e000051. Epub 2019 Aug 6.

Royal Lancaster Infirmary, University Hospital Morecambe Bay NHS Trust (UHMB), Ashton Road, Lancaster, Lancashire, LA1 4RP, UK.

The present report describes a case of infective endocarditis complicated with aortic root abscess caused by in a 56-year-old man. is a microaerophilic, pleomorphic Gram-negative bacillus and member of the species, , , and (HACEK) group, a group of bacteria known to be a rare cause of endocarditis. With prompt diagnosis and initiation of antimicrobial and surgical management, a successful outcome was achieved. Read More

Cureus 2020 Aug 18;12(8):e9827. Epub 2020 Aug 18.

Microbiology, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, IND.

Infective endocarditis (IE) is an infrequent endovascular disease, which can result in significant mortality and morbidity.  and viridans streptococci remain the most common etiological agent. , a member of the HACEK ( species,  species, , , and  species) group of fastidious gram-negative bacillus, is a part of normal upper respiratory flora and a rare cause implicated in IE. Read More

Eur J Clin Microbiol Infect Dis 2021 Mar 18;40(3):525-534. Epub 2020 Sep 18.

Department of Clinical Sciences Lund, Division of Infection Medicine, Lund University, Lund, Sweden.

The objective was to describe the epidemiology, bacteriology, clinical presentation, risk factors for endocarditis (IE), diagnostic workup, and outcome of patients with bacteremia caused by the non-influenzae Haemophilus, Aggregatibacter, Cardiobacterium, Eikenella, and Kingella genera (HACEK). A retrospective population-based cohort of patients with bacteremia collected from 2012 to 2017 was identified. Clinical data from identified patients were collected from medical records to classify patients, calculate incidences, analyze risk factors of IE, and describe the management and outcome of the cohort. Read More

Cancer 2020 12 5;126(23):5124-5136. Epub 2020 Sep 5.

Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, Texas.

Background: Oral mucositis (OM) is a debilitating sequela for patients treated for squamous cell carcinoma of the head and neck (HNSCC). This study investigated whether oral microbial features before treatment or during treatment are associated with the time to onset of severe OM in patients with HNSCC.

Methods: This was a cohort study of newly diagnosed patients with locoregional HNSCC who received chemotherapy with or without radiotherapy from April 2016 to September 2017. Read More

Clin Exp Dent Res 2020 12 6;6(6):659-668. Epub 2020 Aug 6.

Department of Pediatric Dentistry, Tokyo Dental College, Tokyo, Japan.

Background: Biofilm coloration can compromise maturation and increase the risk of oral disease in adulthood, though children with colored biofilm do not always demonstrate a poor oral health status.

Aim: The microbial compositions of colored and white biofilms in children were compared.

Design: Thirty-two dental biofilm samples from 16 children (age < 13 years) were analyzed using 16S rRNA pyrosequencing, then the subjects were divided into severe caries and healthy (caries-free) groups. Read More

Am Surg 2020 Jul 1:3134820933612. Epub 2020 Jul 1.

Division of Vascular Surgery, Department of Surgery, University of Maryland, Baltimore, MD, USA.

BMJ Case Rep 2020 Jul 16;13(7). Epub 2020 Jul 16.

Infectious diseases, CHR Citadelle, Liege, Belgium.

A 76-year-old woman with a rare case of spinal epidural abscess (SEA) that had no risk factors for such type of infection, presented symptoms of back pain, progressive neurological deficit of the lower limb and loss of sphincter control. A gadolinium-enhanced MRI confirmed the diagnosis of an SEA. The patient underwent laminectomy with surgical drainage, where cultures showed the presence of , a bacterium of the HACEK group ( species, species, , , and species), rarely involved in SEA. Read More

Microorganisms 2020 Jun 26;8(6). Epub 2020 Jun 26.

Department of Medical Laboratory Sciences and Biotechnology, Fooyin University, Kaohsiung 83102, Taiwan.

Chronic rhinosinusitis (CRS) is the chronic inflammation of the sinus cavities of the upper respiratory tract, which can be caused by a disrupted microbiome. However, the role of the oral microbiome in CRS is not well understood. Polymicrobial and anaerobic infections of CRS frequently increased the difficulty of cultured and antibiotic therapy. Read More

IDCases 2020 29;21:e00845. Epub 2020 May 29.

Department of Infectious Diseases, Mount Sinai Medical Center, 4300 Alton Road, Miami Beach, FL, USA.

We illustrate the progression of infective endocarditis in a patient with a bioprosthetic mitral valve and decompensated heart failure secondary to an obstructive septic vegetation. Read More

Open Forum Infect Dis 2020 May 13;7(5):ofaa127. Epub 2020 Apr 13.

Maladies Infectieuses et Reanimation Médicale, Inserm CIC 1414, Hôpital Pontchaillou, Centre Hospitalo-Universitaire, Université Rennes 1, Rennes, France.

Background: Increased access to heart valves through early surgery and progress in molecular microbiology have reduced the proportion of infective endocarditis (IE) with no microbiological documentation and increased the proportion of IE associated with unusual microorganisms.

Methods: We performed an ancillary study of a large prospective population-based survey on IE. Unusual-microorganism IE was defined as definite IE (Duke-Li criteria) due to microorganisms other than streptococci, staphylococci, or enterococci. Read More

Int J Syst Evol Microbiol 2020 May;70(5):3167-3178

Department of Biology, Université de Saint-Boniface, Winnipeg, Manitoba, Canada.

The (HACEK) group genus contained a single species, for many years. In November 2019, was described after recovery from a brain abscess and blood culture in Norway. Coincidentally, characterization of 22 Gram-negative bacteria resembling from 17 Canadian patients had been underway. Read More

JAAD Case Rep 2020 Mar 26;6(3):243-246. Epub 2020 Feb 26.

Department of Dermatology, Yale University School of Medicine, New Haven, Connecticut.

J Infect Chemother 2020 May 23;26(5):510-512. Epub 2020 Jan 23.

Department of General Pediatrics, Tokyo Metropolitan Children's Medical Center, Tokyo, Japan.

Eikenella corrodens is a facultatively anaerobic gram-negative rod bacterium in the oropharynx and respiratory tract. It is a member of HACEK (Haemophilus spp., Aggregatibacter spp. Read More

Case Rep Cardiol 2019 4;2019:5907319. Epub 2019 Dec 4.

State University of New York Upstate University Hospital, USA.

Gram-positive cocci species, notably , , and account for 80 to 90% of infective endocarditis cases. HACEK microorganisms ( spp., , , , and ) account for approximately 3% of cases and species account for 1-2% of cases. Read More

Microorganisms 2019 Dec 1;7(12). Epub 2019 Dec 1.

Institute of Microbiology of the CAS, v.v.i., 142 20 Prague, Czech Republic.

Recurrent aphthous stomatitis (RAS) is the most common disease of the oral mucosa, and it has been recently associated with bacterial and fungal dysbiosis. To study this link further, we investigated microbial shifts during RAS manifestation at an ulcer site, in its surroundings, and at an unaffected site, compared with healed mucosa in RAS patients and healthy controls. We sampled microbes from five distinct sites in the oral cavity. Read More