Search Our Scientific Publications & Authors

J Pers Med 2022 Jun 12;12(6). Epub 2022 Jun 12.

Department of Internal Medicine, Inje University Ilsan Paik Hospital, Goyang 10556, Korea.

Background: The authors previously developed deep-learning models for the prediction of colorectal polyp histology (advanced colorectal cancer, early cancer/high-grade dysplasia, tubular adenoma with or without low-grade dysplasia, or non-neoplasm) from endoscopic images. While the model achieved 67.3% internal-test accuracy and 79. Read More

Diagnostics (Basel) 2022 Jun 13;12(6). Epub 2022 Jun 13.

Department of Diagnostic Radiology, Copenhagen University Hospital-Rigshospitalet, 2200 Copenhagen, Denmark.

Previous studies suggest that the most common cause of spontaneous intracerebral hemorrhage in children and adolescents is arteriovenous malformations (AVMs). However, an update containing recently published data on pediatric spontaneous intracranial hemorrhages is lacking. The aim of this study is to systematically analyze the published data on the etiologies and risk factors of pediatric spontaneous intracranial hemorrhage. Read More

Cancers (Basel) 2022 Jun 14;14(12). Epub 2022 Jun 14.

Clinical Research Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA.

Gemtuzumab ozogamicin (GO) improves outcomes when added to intensive AML chemotherapy. A meta-analysis suggested the greatest benefit when combining fractionated doses of GO (GO3) with 7 + 3. To test whether GO3 can be safely used with high intensity chemotherapy, we conducted a phase 1/2 study of cladribine, high-dose cytarabine, G-CSF, and dose-escalated mitoxantrone (CLAG-M) in adults with newly diagnosed AML or other high-grade myeloid neoplasm (NCT03531918). Read More

Cancers (Basel) 2022 Jun 8;14(12). Epub 2022 Jun 8.

Institute of Pathology, University Medical Center Goettingen, Georg-August-University, 37075 Goettingen, Germany.

Tumor grading is a robust prognostic predictor in patients with neuroendocrine neoplasms (NEN) and guides therapy, especially in tumors with high proliferation. NEN can be separated into well-differentiated and poorly differentiated types. The more aggressive NEN have been further separated into neuroendocrine tumors (NET G3) with a better prognosis and neuroendocrine carcinomas (NEC) with a worse prognosis. Read More

Metabolites 2022 Jun 20;12(6). Epub 2022 Jun 20.

Department of Thoracic Surgery, Second Affiliated Hospital of Harbin Medical University, Harbin 150086, China.

Thymomas and thymic carcinomas are malignant thymic epithelial tumors (TETs) with poor outcomes if non-resectable. However, the tumorigenesis, especially the metabolic mechanisms involved, is poorly studied. Untargeted metabolomics analysis was utilized to screen for differential metabolic profiles between thymic cancerous tissues and adjunct noncancerous tissues. Read More

Curr Oncol 2022 Jun 15;29(6):4260-4266. Epub 2022 Jun 15.

Division of Medical Oncology, Canadian Sarcoma Research and Clinical Collaboration (CanSaRCC), Princess Margaret Cancer Centre-University Health Network, Toronto, ON M5G 2C1, Canada.

Sarcoma can present as locally advanced disease involving pleura for which extra-pleural pneumonectomy (EPP) may be the only surgical option to ensure adequate local control. Data were collected on patients who underwent EPP between January 2009 and August 2021 at Princess Margret Hospital and SickKids (Toronto) using the CanSaRCC (Canadian Sarcoma Research and Clinical Collaboration). Ten patients with locally advanced sarcoma involving the pleura, aged 4 to 59 years (median 19. Read More

Future Cardiol 2022 Jun 23. Epub 2022 Jun 23.

Department of Environmental & Occupational Health, School of Public Health, Texas A & M University, College Station, TX 77843, USA.

We evaluated the characteristics of the top 50 most cited articles on cardiac tumors using bibliometric analysis. Independent reviewers queried the Web of Science database for articles within the past 50 years. Most articles were published between 1991 and 2016, 18% (9/50) of the first authors were women, 52% (26/50) of the articles were focused on cardiac imaging in addition to other aspects of cardiac tumors and only 61. Read More

Future Cardiol 2022 Jun 23. Epub 2022 Jun 23.

Cardiovascular Disease, University of Michigan-West, Wyoming, 49519, Michigan.

Gorlin-Goltz syndrome is a rare autosomal dominant disease characterized by odontogenic keratocysts and basal cell carcinoma as well as ophthalmic and neurological implications. The following article presents the case of a 20-year-old female with Gorlin-Goltz syndrome incidentally found to have a cardiac mass. An ECG showed diffuse T-wave inversions in the lateral leads despite a lack of any acute coronary symptoms in the patient. Read More

Sci Rep 2022 Jun 22;12(1):10532. Epub 2022 Jun 22.

Department of Internal Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, 138 Sheng Li Road, Tainan, 704, Taiwan.

Tumor endothelial marker 1 (TEM1) is a transmembrane glycoprotein that appears on mesenchymal lineage-derived cells during embryogenesis, but its expression greatly reduces after birth. Re-upregulation of TEM1 is found in tumor angiogenesis, organ fibrosis and wound healing indicating its potential role in tissue remodeling and repair. The expression level and function of TEM1 in adult heart are unknown. Read More

Sci Adv 2022 Jun 22;8(25):eabn3471. Epub 2022 Jun 22.

Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC 20057, USA.

Temozolomide (TMZ) is a chemotherapeutic agent that has been the first-line standard of care for the aggressive brain cancer glioblastoma (GBM) since 2005. Although initially beneficial, TMZ resistance is universal and second-line interventions are an unmet clinical need. Here, we took advantage of the known mechanism of action of TMZ to target guanines (G) and investigated G-rich G-quadruplex (G4) and splice site changes that occur upon TMZ resistance. Read More

Curr Opin Cardiol 2022 Jul;37(4):372-379

Franciscan CardioOncology Center, IC-OS Center of Excellence, Indiana Heart Physicians, Franciscan Health, Indianapolis, Indiana, USA.

Purpose Of Review: Recent advances in oncologic therapies have significantly improved overall survival for patients with malignancy. However, cardiovascular complications have not only increased in this population due to shared risk factors and pathophysiology, but also due to the therapies themselves. One key mechanism that warrants further attention is accelerated atherosclerosis due to these agents. Read More

Cien Saude Colet 2022 Jul 23;27(7):2655-2665. Epub 2021 Dec 23.

Faculdade de Ciências Médicas, Universidade Estadual de Campinas. R. Tessália Vieira de Camargo 126, Cidade Universitária. 13083-887 Campinas SP Brasil.

This article aims to estimate the prevalence of chronic diseases/conditions in octogenarians according to sex, age groups and private health insurance, and its relationship with difficulty in performing usual activities. Cross-sectional population-based study with elderly data (n = 6,098) from the National Health Survey (PNS) 2019. Prevalences and 95% confidence intervals were estimated. Read More

BMC Cancer 2022 Jun 21;22(1):682. Epub 2022 Jun 21.

Department of Radiation Oncology, University Hospital of Freiburg, Robert-Koch-Strasse 3, 79106, Freiburg, Germany.

Background: Radiotherapy using the deep inspiration breath-hold (DIBH) technique compared with free breathing (FB) can achieve substantial reduction of heart and lung doses in left-sided breast cancer cases. The anatomical organ movement in deep inspiration also cause unintended exposure of locoregional lymph nodes to the irradiation field.

Methods: From 2017-2020, 148 patients with left-sided breast cancer underwent breast conserving surgery (BCS) or mastectomy (ME) with axillary lymph node staging, followed by adjuvant irradiation in DIBH technique. Read More

Sci Rep 2022 Jun 21;12(1):10458. Epub 2022 Jun 21.

Computational Biology and Clinical Informatics, Baker Heart and Diabetes Institute, Melbourne, VIC, 3004, Australia.

BRCA1 and BRCA2 are tumour suppressor genes that play a critical role in maintaining genomic stability via the DNA repair mechanism. DNA repair defects caused by BRCA1 and BRCA2 missense variants increase the risk of developing breast and ovarian cancers. Accurate identification of these variants becomes clinically relevant, as means to guide personalized patient management and early detection. Read More

PLoS Genet 2022 Jun 21;18(6):e1010260. Epub 2022 Jun 21.

Telomeres and Telomerase Group, Molecular Oncology Program, Spanish National Cancer Centre (CNIO), Madrid, Spain.

The shelterin protein POT1 has been found mutated in many different familial and sporadic cancers, however, no mouse models to understand the pathobiology of these mutations have been developed so far. To address the molecular mechanisms underlying the tumorigenic effects of POT1 mutant proteins in humans, we have generated a mouse model for the human POT1R117C mutation found in Li-Fraumeni-Like families with cases of cardiac angiosarcoma by introducing this mutation in the Pot1a endogenous locus, knock-in for Pot1aR117C. We find here that both mouse embryonic fibroblasts (MEFs) and tissues from Pot1a+/ki mice show longer telomeres than wild-type controls. Read More

Stress 2022 Jan;25(1):258-266

National Heart, Lung, and Blood Institute, Bethesda, MD, USA.

Chronic stress is a well-established risk factor for cardiometabolic disease. Caregiving for individuals with cancer is perceived as a chronic stressor yet research on the risk for cardiometabolic disease in this population, opposed to the elderly and those with Alzheimer's disease, is limited. Additionally, few studies have explored the early physiological changes that occur in family caregivers suggesting an elevated risk for illness. Read More

J Investig Med High Impact Case Rep 2022 Jan-Dec;10:23247096221104469

SUNY Upstate Medical University, Syracuse, NY, USA.

Lipoma of the interventricular septum involving the tricuspid valve is a rare entity. A 50-year-old woman presented with exertional dyspnea. She was found to have a large right interventricular septal mass in the initial transthoracic echocardiography. Read More

J Card Surg 2022 Jun 21. Epub 2022 Jun 21.

Department of Cardiovascular Surgery, Osaka Women's and Children's Hospital, Osaka, Japan.

Rhabdomyomas associated with tuberous sclerosis are common cardiac tumors in children, and no surgical intervention is needed in most cases. However, when the tumor causes left ventricular outlet tract obstruction (LVOTO), immediate surgical intervention is indicated. Here, we report a newborn who was diagnosed antenatally with multiple cardiac rhabdomyomas, one of which blocked the aortic valve during systole. Read More

BMC Cardiovasc Disord 2022 Jun 17;22(1):272. Epub 2022 Jun 17.

Section of Cardiac Electrophysiology, Division of Cardiovascular Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

Background: The aim of this study is to assess the burden of AF-related hospitalizations inclusive of inflation-adjusted cost-of-care and length-of-stay (LOS) among cancer patients and the impact of direct current cardioversion (DCCV) on these outcomes.

Methods: Using the National Inpatient Sample (NIS), patients hospitalized with either a primary or secondary diagnosis of AF and comorbid cancer were identified and both cost of hospitalization and LOS were evaluated for each group. Subgroup analyses were performed for specific cancer types (breast, lung, colon, prostate and lymphoma), and those receiving DCCV. Read More

BMC Cancer 2022 Jun 20;22(1):673. Epub 2022 Jun 20.

Department of Surgery, Division of Radiation Oncology and Developmental Radiotherapeutics, University of British Columbia, Vancouver, BC, Canada.

Background: A novel device for supine positioning in breast radiotherapy for patients with large or pendulous breasts has been developed and tested in phase II studies. This trial is designed to assess the efficacy of the device to reduce skin toxicity and unwanted normal tissue dose in comparison to the current clinical standard for supine breast support during breast radiotherapy.

Methods: Patients at high risk for moist desquamation, having infra-mammary fold or lateral ptosis, will be randomized into two arms. Read More

Indian J Radiol Imaging 2022 Mar 19;32(1):132-135. Epub 2022 Apr 19.

Department of Thoracic and vascular Surgery, Government Medical College Hospital, Thiruvananthapuram, Kerala, India.

Congenital pericardial cysts are very rare neoplasms of the middle mediastinum. We report a case of a young woman who was referred to the surgical department with abdominal pain. The ultrasound done showed moderate ascites and pleural effusion. Read More

Am J Ophthalmol Case Rep 2022 Sep 23;27:101590. Epub 2022 May 23.

Department of Pathology, Faculty of Medicine, University of Kelaniya, Sri Lanka.

Purpose: This is a case report of a patient with a conjunctival myxoid stromal tumor (COMST), mimicking a phlyctenulosis. Tumors of the conjunctiva and cornea occupy a large spectrum ranging from benign lesions of myxoma to aggressive, life-threatening malignancies. Phlyctenulosis and phlyctenular keratoconjunctivitis are hypersensitivity reactions to a foreign antigen. Read More

Am Heart J Plus 2022 Mar 1;15. Epub 2022 Apr 1.

Department of Cardiovascular Diseases, Mayo Clinic, Rochester, MN, USA.

Cardiovascular disease is a leading cause of death among cancer survivors, second only to cancer recurrence or development of new tumors. Cardio-oncology has therefore emerged as a relatively new specialty focused on prevention and management of cardiovascular consequences of cancer therapies. Yet challenges remain regarding precision and accuracy with predicting individuals at highest risk for cardiotoxicity. Read More

Front Pharmacol 2022 2;13:902459. Epub 2022 Jun 2.

Department of Pharmacy, The Fourth Affiliated Hospital of Harbin Medical University, Harbin, China.

Cardiotonic steroids (CTS) are a group of compounds existing in animals and plants. CTS are commonly referred to cardiac glycosides (CGs) which are composed of sugar residues, unsaturated lactone rings and steroid cores. Their traditional mechanism of action is to inhibit sodium-potassium ATPase to strengthen the heart and regulate heart rate, so it is currently widely used in the treatment of cardiovascular diseases such as heart failure and tachyarrhythmia. Read More

Comput Intell Neurosci 2022 8;2022:8749353. Epub 2022 Jun 8.

School of Engineering, Department of Computer Science and Engineering, Kathmandu University, Dhulikhel, Kavre 45200, Nepal.

Advanced predictive analytics coupled with an effective attribute selection method plays a pivotal role in the precise assessment of chronic disorder risks in patients. Traditional attribute selection approaches suffer from premature convergence, high complexity, and computational cost. On the contrary, heuristic-based optimization to supervised methods minimizes the computational cost by eliminating outlier attributes. Read More

Cureus 2022 Jun 16;14(6):e26014. Epub 2022 Jun 16.

Cardiology, Maimonides Medical Center, Brooklyn, USA.

Cardiac tumors are an uncommon phenomenon. Although they can be cardiac in origin, most represent a distant neoplastic growth metastasizing to the heart. Cardiac tumors can be benign or malignant. Read More

Front Immunol 2022 2;13:903562. Epub 2022 Jun 2.

Max Planck Institute for Heart and Lung Research, Member of the German Center for Lung Research Deutsches Zentrum für Lungenforschung (DZL), Member of the Cardio-Pulmonary Institute (CPI), Bad Nauheim, Germany.

The present treatments for lung cancer include surgical resection, radiation, chemotherapy, targeted therapy, and immunotherapy. Despite advances in therapies, the prognosis of lung cancer has not been substantially improved in recent years. Chimeric antigen receptor (CAR)-T cell immunotherapy has attracted growing interest in the treatment of various malignancies. Read More

J Med Case Rep 2022 Jun 20;16(1):243. Epub 2022 Jun 20.

Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Indonesia, Persahabatan National Respiratory Referral Hospital, Jakarta, Indonesia.

Background: Adenoid cystic carcinoma of the lung is a distinctive salivary-gland-type malignant epithelial neoplasm that rarely presents as a primary tumor of the respiratory tract. Complete surgical resection remains the treatment of choice for adenoid cystic carcinoma. We present a case of large ACC tumors that caused severe central airway obstruction and were effectively treated with therapeutic bronchoscopy followed by radiotherapy and chemotherapy. Read More

Heart Fail Clin 2022 Jul;18(3):xv-xvii

Division of Cardiology, AORN Antonio Cardarelli Hospital, Naples, Italy. Electronic address:

Heart Fail Clin 2022 Jul;18(3):515-528

Division of Cancer Prevention, NCI, NIH, 9609 Medical Center Dr. Room 5E342, Bethesda, MD 20892, USA.

Advances in cancer treatments have led to nearly 17 million survivors in the US today. Cardiovascular complications attributed to cancer treatments are the leading cause of morbidity and mortality in cancer survivors. In response, NCI and NHLBI held 2 workshops and issued funding opportunities to strengthen research on cardiotoxicity. Read More