50,349 results match your criteria Cardiac Tumors


Coronary artery thromboembolism: Unexpected presentation of left atrial myxoma covered with thrombus.

J Card Surg 2020 Jul 11. Epub 2020 Jul 11.

Department of Pathology, Dr Lutfi Kirdar Kartal Egitim ve Arastirma Hastanesi, Istanbul, Turkey.

Cardiac myxomas are benign primer cardiac tumors of the heart. They can be fatal with a thromboembolic presentation. Myocardial infarction is one of these unusual thromboembolic presentations. Read More

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http://dx.doi.org/10.1111/jocs.14830DOI Listing

Sudden death by massive systemic embolism from cardiac myxoma. Role of the clinical autopsy and review of literature.

Cardiovasc Pathol 2020 May 23;49:107244. Epub 2020 May 23.

Area of Pathology, Department of Woman and Child Health and Public Health, Fondazione Policlinico Universitario A. Gemelli IRCCS, Istituto di Anatomia Patologica, Università Cattolica Del Sacro Cuore, Rome, Italy.

Cardiac myxoma is a rare benign neoplasm of the heart. Historically myxomas were incidental findings during autopsies, however improved imaging techniques made these diagnosis possible in living patients, making the surgical treatment of these neoplasms achievable. Cardiac myxomas may occur both sporadically and in a familial context, often in the clinico-pathological picture of the Carney complex. Read More

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http://dx.doi.org/10.1016/j.carpath.2020.107244DOI Listing

Congestive heart failure and upper extremity deep vein thrombosis: A rare presentation of a pheochromocytoma.

Authors:
Eman M Alfadhli

J Taibah Univ Med Sci 2020 Jun 1;15(3):244-248. Epub 2020 May 1.

Medicine Department, Taibah University, Medical College, Girls Section, Almadinah Almunawwarah, KSA.

Pheochromocytomas are rare catecholamine-secreting neoplasms, occurring in approximately 0.1-0.5% of the patients with hypertension. Read More

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http://dx.doi.org/10.1016/j.jtumed.2020.03.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7336017PMC

Survival of patients with newly diagnosed high-grade myeloid neoplasms who do not meet standard trial eligibility.

Haematologica 2020 Jul 9. Epub 2020 Jul 9.

University of Washington.

Few patients with cancer, including those with acute myeloid leukemia and high-grade myeloid neoplasms, participate in clinical trials. Broadening standard eligibility criteria may increase clinical trial participation. In this retrospective single-center analysis, we identified 442 consecutive newly diagnosed patients from 2014 to 2016. Read More

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http://dx.doi.org/10.3324/haematol.2020.254938DOI Listing

Primary myxoid temporal bone tumor: A rare neurosurgical manifestation of Carney complex?

Surg Neurol Int 2020 27;11:166. Epub 2020 Jun 27.

Department of Neurosurgery, Shinshu University School of Medicine, Asahi, Matsumoto, Nagano, Japan.

Background: Carney complex (CNC) is a rare autosomal dominant syndrome, manifesting mainly with cardiac, cutaneous, and mucosal myxomas. Osteochondromyxoma is known as an extremely rare bone lesion of CNC which usually appears early in life; however, there were no reports of primary bone myxoma of the skull in the patients with CNC. We present the first case of primary myxoid skull tumor in the patient with CNC. Read More

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http://dx.doi.org/10.25259/SNI_170_2020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7332703PMC

Assessment of Oxidative Stress in Patients with Chronic Myeloid Leukemia Depending on Associated Comorbidities.

Curr Health Sci J 2020 Jan-Mar;46(1):23-30. Epub 2020 Mar 31.

University of Medicine and Pharmacy of Craiova, Romania.

Oxidative stress (OS) implies an imbalance between the amount of tissue level of prooxidant and antioxidant compounds. It is involved in the pathophysiology of multiple pathological entities (neoplasms, disorders of carbohydrate and lipid metabolism, cardiovascular and renal pathology etc.), as well as in the pharmacokinetics of specific treatments for these pathologies. Read More

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http://dx.doi.org/10.12865/CHSJ.46.01.04DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7323725PMC

A rare disease of primary cardiac intimal sarcoma at the left atrium presented with mimicking mitral stenosis in a patient with polycystic kidney disease.

Authors:
Ji-Won Hwang

J Cardiol Cases 2020 Jul 18;22(1):5-10. Epub 2020 Apr 18.

Division of Cardiology, Department of Medicine, Ilsan Paik Hospital, Inje University School of Medicine, Goyang 10380, Republic of Korea.

A 55-year-old woman presented with a history of constitutional symptoms with exertional dyspnea, orthopnea, and cough for one month. She developed progressive heart failure symptoms. Initial computed tomography revealed a large left atrial mass with compression of pulmonary veins and mitral valve. Read More

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http://dx.doi.org/10.1016/j.jccase.2020.03.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7326662PMC

Stroke mimics in patients clinically diagnosed with stroke at a tertiary teaching hospital in Tanzania: a prospective cohort study.

BMC Neurol 2020 Jul 7;20(1):270. Epub 2020 Jul 7.

Department of Internal Medicine, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania.

Background: Stroke mimics account for up to one-third of acute stroke admissions and are a heterogeneous entity which pose diagnostic challenges. Diagnosing such patients is however crucial to avoid delays in treatment and potentially harmful medication prescription. We aimed at describing the magnitude, clinical characteristics and short-term outcomes of stroke mimics in patients clinically diagnosed with a stroke. Read More

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http://dx.doi.org/10.1186/s12883-020-01853-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7339381PMC

Combined PET/CT with thoracic contrast-enhanced CT in assessment of primary cardiac tumors in adult patients.

EJNMMI Res 2020 Jul 6;10(1):75. Epub 2020 Jul 6.

WeiLun PET Center, Department of Nuclear Medicine, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Room 517, 5/F, Weilun Building of Guangdong Provincial People's Hospital, 106 Zhongshan Er Road, Guangzhou, 510080, Guangdong, People's Republic of China.

Background: F-FDG PET/CT is a key molecular imaging modality to noninvasively assess and differentiate benign and malignant cardiac tumors. However, few benign cardiac tumors can be characterized by increased F-FDG uptake, which makes differential diagnosis difficult. This study sought to retrospectively evaluate whether combined F-FDG PET/CT with thoracic contrast-enhanced CT (CECT) helps in assessing primary cardiac tumors in adult patients, compared with CECT or PET/CT alone. Read More

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http://dx.doi.org/10.1186/s13550-020-00661-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7338301PMC

Basal cell carcinoma misdiagnosed as trichoepithelioma.

Arch Craniofac Surg 2020 Jun 29;21(3):202-205. Epub 2020 Jun 29.

Department of Plastic and Reconstructive Surgery, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang, Korea.

Trichoepithelioma is a benign hair follicle tumor that can undergo malignant transformation into basal cell carcinoma in rare cases. Due to the similar clinical and histological features of trichoepithelioma and basal cell carcinoma, distinguishing between these types of tumors can be a diagnostic challenge. Punch biopsy obtains only a small sample of the entire lesion, and thus inherently involves a risk of misdiagnosis between histologically similar diseases. Read More

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http://dx.doi.org/10.7181/acfs.2020.00157DOI Listing

Cardiac tumors: three decades of experience from a tertiary center: are we changing diagnostic work-up with new imaging tools?

Cardiovasc Pathol 2020 May 18;49:107242. Epub 2020 May 18.

Cardiothoracic Surgery Department, Hospital de Santa Cruz - Centro Hospitalar de LisboaOcidental, Carnaxide, Portugal.

Background: Primary cardiac tumours are relatively rare. Cardiac myxomas are the most prevalent and in a significant proportion of cases they are accidentally discovered in asymptomatic patients. Noninvasive definitive diagnosis remains challenging despite improvements provided by newer imaging tools. Read More

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http://dx.doi.org/10.1016/j.carpath.2020.107242DOI Listing

Frailty in patients with mild autonomous cortisol secretion is higher than in patients with nonfunctioning adrenal tumors.

J Clin Endocrinol Metab 2020 Jul 6. Epub 2020 Jul 6.

Division of Endocrinology, Diabetes, Metabolism, and Nutrition, Mayo Clinic, Rochester, MN.

Context: Mild autonomous cortisol secretion (MACS) affects up to 50% of patients with adrenal adenomas. Frailty is a syndrome characterized by the loss of physiological reserves and an increase in vulnerability, and serves as a marker of declining health.

Objective: To compare frailty in patients with MACS versus nonfunctioning adrenal tumors (NFAT). Read More

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http://dx.doi.org/10.1210/clinem/dgaa410DOI Listing

Cardiac MRI utilizing late gadolinium enhancement (LGE) and T1 mapping in the detection of radiation induced heart disease.

Cardiooncology 2020 1;6. Epub 2020 Jul 1.

Department of Radiation Oncology, Virginia Commonwealth University Health System, 401 College Street, Richmond, VA 23298 USA.

Background And Purpose: Radiotherapy has been associated with late dose-dependent cardiovascular toxicity. In this cross-sectional pilot study, radiation dose distributions were correlated with areas of localized and diffuse myocardial fibrosis as measured by novel cardiac MRI (CMR) sequences including late gadolinium enhancement (LGE) and T1 mapping with the goal to identify early markers of myocardial damage.

Materials And Methods: Twenty-eight patients with chest tumors including lung, breast, esophagus, and lymphoma underwent CMR per study protocol on average 46. Read More

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http://dx.doi.org/10.1186/s40959-020-00061-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7329507PMC

Pharmacogenomics for Immunotherapy and Immune-related Cardiotoxicity.

Hum Mol Genet 2020 Jul 3. Epub 2020 Jul 3.

Genomic Medicine Institute, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA.

Immune checkpoint blockade (ICB) has become a standard of care in a subset of solid tumors. Although cancer survivorship has extended, rates of durable response of ICB remain poor; furthermore, cardiac adverse effects are emerging which impacts several mechanical aspects of the heart. Cardio-oncology programs implement a clinical assessment to curtail cardiovascular disease progression but are limited to the current clinical parameters used in cardiology. Read More

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http://dx.doi.org/10.1093/hmg/ddaa137DOI Listing

Application of Echocardiographic Information Technology in the Research of Infective Endocarditis and Its Neurological Complications.

Neurosci Lett 2020 Jun 27:135217. Epub 2020 Jun 27.

Department of Ultrasonography, Guangdong Provincial Hospital of Chinese Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou City, 510120, Guangdong Province, China. Electronic address:

The study aimed to analyze the application of echocardiography information technology in the investigation of infective endocarditis (IE), and discuss the central neurological complications in IE patients. 78 patients with infective endocarditis who were treated in our hospital were selected as the research subjects. Their prevalence was classified and summarized, such as clinical manifestations, whether there is a history of heart disease, heart disease treatment, echocardiographic performance, and patient outcomes. Read More

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http://dx.doi.org/10.1016/j.neulet.2020.135217DOI Listing

[Somatic mutation of the V617F JAK2 gene in patients of the cardiovascular diseases].

Ter Arkh 2019 Jul 15;91(7):25-28. Epub 2019 Jul 15.

The Federal Center of Cardiovascular Surgery of Krasnoyarsk.

The JAK2 V617F somatic mutation is one of the most frequent markers of CHIP (clonal hematopoiesis of indeterminate potential). CHIP is characterized by the presence of a myeloid cells clone in peripheral blood in the absence of the sufficient reasons to diagnose the hematologic disease. The CHIP is proposed as a potential independent risk factor for vascular pathology. Read More

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http://dx.doi.org/10.26442/00403660.2019.07.000245DOI Listing

Coronary Event Analysis in Breast Cancer Patients Who Received Breast-Conserving Surgery and Post-Operative Radiotherapy: a Korean Nationwide Cohort Study.

J Breast Cancer 2020 Jun 29;23(3):291-302. Epub 2020 Apr 29.

Review and Assessment Committee, Korean Health Insurance Review & Assessment Service, Wonju, Korea.

Purpose: Adjuvant breast radiotherapy (RT) following breast-conserving surgery (BCS) has been reported to induce cardiac toxicity in breast cancer patients. We investigated the incidence and risk factors of major coronary events after breast RT using Korean nationwide Health Insurance Review and Assessment data.

Methods: Using data from a nationwide quality assessment of breast cancer treatment, we identified 3,251 patients who received breast RT after BCS in 2013. Read More

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http://dx.doi.org/10.4048/jbc.2020.23.e30DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7311360PMC

Hospitalisation at the end of life among cancer and non-cancer patients in Denmark: a nationwide register-based cohort study.

BMJ Open 2020 Jun 28;10(6):e033493. Epub 2020 Jun 28.

Danish Center for Clinical Health Services Research, Aalborg University, Aalborg, Denmark

Objectives: End-of-life hospitalisations may not be associated with improved quality of life. Studies indicate differences in end-of-life care for cancer and non-cancer patients; however, data on hospital utilisation are sparse. This study aimed to compare end-of-life hospitalisation and place of death among patients dying from cancer, heart failure or chronic obstructive pulmonary disease (COPD). Read More

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http://dx.doi.org/10.1136/bmjopen-2019-033493DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7322325PMC

A prospective, randomized, controlled study assessing vagus nerve stimulation using the gammaCore®-Sapphire device for patients with moderate to severe CoViD-19 Respiratory Symptoms (SAVIOR): A structured summary of a study protocol for a randomised controlled trial".

Trials 2020 Jun 26;21(1):576. Epub 2020 Jun 26.

Hospital Clínico Universitario de Valencia, Anaesthesia, Critical Care and Pain Management Unit, Valencia, Spain.

Objectives: Primary Objective: The primary objective is to reduce initiation of mechanical ventilator dependency in patients with moderate to severe CoViD- 19. This will be measured as the difference between the control group and active group for subjects admitted to the hospital for CoViD-19. Secondary Objectives: • To evaluate cytokine trends / Prevent cytokine storms • To evaluate supplemental oxygen requirements • To decrease mortality of CoViD-19 patients • Delay onset of ventilation TRIAL DESIGN: The study is a single centre, 2-arm, prospective, randomized (ratio 1:1), controlled trial with parallel groups design to compare the reduction of respiratory distress in a CoViD-19 population, using the intervention of the gammaCore®-Sapphire device plus standard of care (active) vs. Read More

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http://dx.doi.org/10.1186/s13063-020-04486-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7316576PMC

A rare case of multimetastatic cardiac angiosarcoma.

Radiol Case Rep 2020 Aug 18;15(8):1271-1274. Epub 2020 Jun 18.

Department of Pathology, Cliniques Universitaires Saint-Luc, Brussels, Belgium.

Cardiac malignant tumors are rare entities with nonspecific clinical presentation and poor prognosis. Here, we report a case of about a 30-year-old man who was admitted for right thoracic pain. Imaging indicated a cardiac malignant tumor, and pathology confirmed the diagnosis. Read More

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http://dx.doi.org/10.1016/j.radcr.2020.05.051DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7305366PMC

[The clinical characteristics and surgical management of ciliated muconodular papillary tumor].

Zhonghua Zhong Liu Za Zhi 2020 Jun;42(6):491-494

Department of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.

To investigate the clinical characteristics and surgical management based on the clinical manifestation, pathological feature and the medical imaging finding of ciliated muconodular papillary tumor (CMPT). The data of clinical manifestation, pathological feature and the medical imaging finding of 15 patients with CMPT who received surgical treatment from January 2017 to April 2019 were collected and retrospectively analyzed. CMPT generally occurred in the elderly people. Read More

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http://dx.doi.org/10.3760/cma.j.cn112152-20190829-00555DOI Listing

[Subclinical heart injury in patients receiving hypofractionated radiotherapy after breast conserving surgery: a preliminary analysis of prospective study].

Zhonghua Zhong Liu Za Zhi 2020 Jun;42(6):456-462

Department of Radiation Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.

To evaluate the incidence of early cardiac injury in patients with left-sided breast cancer receiving hypofractionated radiotherapy after breast conserving surgery, and to investigate the correlation between cardiac injury and hypofractionated radiotherapy dose. We prospectively enrolled 103 breast cancer patients who received whole breast with or without regional nodal irradiation after breast conserving surgery using either deep inspiration breath-hold (DIBH) or free breathing (FB) radiotherapy technique. Cardiac examinations that included N-terminal pro-B-type natriuretic peptide (NT-proBNP), electrocardiogram, and myocardial perfusion imaging were performed routinely before and after radiotherapy. Read More

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http://dx.doi.org/10.3760/cma.j.cn112152-20200131-00057DOI Listing

Fetal Intrapericardial Teratomas: An Update.

Authors:
Shi-Min Yuan

Z Geburtshilfe Neonatol 2020 Jun 23. Epub 2020 Jun 23.

The First Hospital of Putian, Teaching Hospital, Fujian Medical University, Department of Cardiothoracic Surgery, Putian, China.

Fetal intrapericardial teratomas are rare and benign cardiac tumors. By comprehensive literature retrieval of the pertinent articles published since 2000, 49 articles with 61 cases of intrapericadial teratomas were recruited into this study. The intrapericardial teratomas were found during pregnancy in 55 cases (fetal group), while the tumors were detected until neonatal period in 6 cases (neonatal group). Read More

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http://dx.doi.org/10.1055/a-1114-6572DOI Listing

A case of surgically resected cardiac rhabdomyoma with progressive left ventricular outflow tract obstruction.

Cardiovasc Pathol 2020 May 12;49:107226. Epub 2020 May 12.

Department of Pathology, Universiti Kebangsaan Malaysia Medical Centre, 56000 Kuala Lumpur, Malaysia. Electronic address:

Cardiac rhabdomyoma is the most prevalent cardiac tumors in the pediatric population, in close association with tuberous sclerosis complex. It is usually detected antenatally or postnatally by echocardiography. Clinical presentations depend greatly on the size and position of the tumor mass. Read More

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http://dx.doi.org/10.1016/j.carpath.2020.107226DOI Listing

[Resection of recurrent hemangioma of the anterior mediastinum with aortic arch replacement and simultaneous resection of left atrial myxoma].

Khirurgiia (Mosk) 2020 (6):114-117

Sechenov First Moscow State Medical University of the Ministry of Health of Russia (Sechenov University), Moscow, Russia.

Patients with anterior mediastinum tumors fall into a difficult category due to high risk of invasion of vital structures and complexity of surgical correction. We report resection of recurrent hemangioma of anterior mediastinum with aortic arch replacement and simultaneous resection of left atrial myxoma in a 35-year-old woman. Successful treatment of these patients correlates with aggressive surgical approach followed by total resection of tumor and all affected vessels and other tissues. Read More

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http://dx.doi.org/10.17116/hirurgia2020061114DOI Listing

Diffuse infantile hepatic hemangiomas in a patient with Beckwith-Wiedemann syndrome: A new association?

Am J Med Genet A 2020 Jun 23. Epub 2020 Jun 23.

Rare Diseases and Clinical Genetics Unit, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.

Beckwith-Wiedemann syndrome (BWS) is an overgrowth syndrome, caused by alterations in a cluster of imprinted genes located within the chromosome region 11p15.5. Common clinical features are overgrowth, macroglossia, lateralized overgrowth, abdominal wall defects, neonatal hypoglycemia and an increased risk of embryonal tumors, such as hepatoblastomas. Read More

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http://dx.doi.org/10.1002/ajmg.a.61718DOI Listing

Medical Comorbidities and Association With Mortality Risk in Alzheimer's Disease: Population-Based Study of 132,405 Geriatric Inpatients.

Cureus 2020 May 19;12(5):e8203. Epub 2020 May 19.

Psychiatry, Griffin Memorial Hospital, Norman, USA.

Objectives We used the Nationwide Inpatient Sample (NIS) to identify the demographic predictors and study the impact of chronic comorbidities on the risk of in-hospital mortality in Alzheimer's disease (AD). Methods We included 132,405 AD patients from the NIS (2012-2014). We used descriptive statistics to discern the differences in demographics and comorbidities by in-hospital mortality. Read More

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http://dx.doi.org/10.7759/cureus.8203DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7303507PMC

Trp53 and Rb1 regulate autophagy and ligand-dependent Hedgehog signaling.

J Clin Invest 2020 Jun 22. Epub 2020 Jun 22.

Hudson Institute of Medical Research, Clayton, Victoria, Australia.

Ligand-dependent activation of Hedgehog (Hh) signaling in cancer occurs without mutations in canonical pathway genes. Consequently, the genetic basis of Hh pathway activation in adult solid tumors, such as small-cell lung cancer (SCLC), is unknown. Here we show that combined inactivation of Trp53 and Rb1, a defining genetic feature of SCLC, leads to hypersensitivity to Hh ligand in vitro, and during neural tube development in vivo. Read More

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http://dx.doi.org/10.1172/JCI132513DOI Listing

Primary left ventricular neuroendocrine tumor in a middle-aged female: a case report.

Ann Transl Med 2020 May;8(10):653

Department of Radiology, West China Hospital, Sichuan University, Chengdu 610041, China.

Primary neuroendocrine tumors (NETs) in the heart are exceptionally rare. Here, we report a case found at our hospital of a 51-year-old woman with a primary left ventricular NET. The patient presented with non-causal recurrent diarrhea for 2 years, abdominal pain, and vomiting. Read More

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http://dx.doi.org/10.21037/atm-20-3049DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7290606PMC

Cardiac Tumors.

J Cardiovasc Echogr 2020 Apr 10;30(Suppl 1):S45-S53. Epub 2020 Apr 10.

Department of General Surgery and Medical-Surgery Specialities, University of Catania, Catania, Italy.

Cardiac tumors (CTs) are extremely rare, with an incidence of approximately 0.02% in autopsy series. Primary tumors of the heart are far less common than metastatic tumors. Read More

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http://dx.doi.org/10.4103/jcecho.jcecho_7_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7293869PMC

A riddle yet unsolved: two case reports of primary cardiac sarcoma.

Acta Chir Belg 2020 Jun 30:1-5. Epub 2020 Jun 30.

Department of Cardiac, Thoracic, and Vascular Surgery, Lithuanian University of Health Sciences, Kaunas, Lithuania.

Primary malignant cardiac tumors are exceedingly rare and dangerous, often leading to very early death after initial symptom presentation. Each case poses a unique challenge, as no standardized practice guidelines have been developed due to their sheer rarity. Surgical excision and adjuvant therapy remain the mainstays of treatment. Read More

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http://dx.doi.org/10.1080/00015458.2020.1785217DOI Listing

Calcified mass in the right atrium extending into the inferior vena cava with pulmonary artery embolization. Typical or atypical myxoma?

Echocardiography 2020 Jun 21. Epub 2020 Jun 21.

Department of Cardiac MRI, Allegheny General Hospital, Pittsburgh, PA, USA.

Cardiac masses are divided into neoplastic and non-neoplastic. They usually represent a diagnostic challenge given their relative rarity, their infrequent symptoms, and the overall difficulty with dynamic imaging of the heart. While echocardiography is useful in the initial evaluation of a suspected mass, cardiac magnetic resonance (CMR) imaging is the best imaging modality to characterize cardiac tumors due to its superior tissue characterization and its higher contrast resolution. Read More

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http://dx.doi.org/10.1111/echo.14629DOI Listing

Diagnostic Accuracy of Cardiac Computed Tomography and F-Fluorodeoxyglucose With Positron Emission Tomography in Cardiac Masses.

JACC Cardiovasc Imaging 2020 Jun 17. Epub 2020 Jun 17.

Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy.

Objectives: This study sought to assess the diagnostic accuracy of cardiac computed tomography (CT) and F-fluorodeoxyglucose (F-FDG) with positron emission tomography/computed tomography (PET/CT) in defining the nature of cardiac masses.

Background: The diagnostic accuracy of cardiac CT and F-FDG PET/CT in identifying the nature of cardiac masses has been analyzed to date only in small samples.

Methods: Of 223 patients with echocardiographically diagnosed cardiac masses, a cohort of 60 cases who underwent cardiac CT and F-FDG PET/CT was selected. Read More

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http://dx.doi.org/10.1016/j.jcmg.2020.03.021DOI Listing

Surgical Approach to Abdominal Tumors Involving the Inferior Vena Cava.

Isr Med Assoc J 2020 Jun;22(6):364-368

Department of Surgery, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.

Background: Abdominal tumors invading the inferior vena cava (IVC) present significant challenges to surgeons and oncologists.

Objectives: To describe a surgical approach and patient outcomes.

Methods: The authors conducted a retrospective analysis of surgically resected tumors with IVC involvement by direct tumor encasement or intravascular tumor growth. Read More

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Multiple intra-cardiac masses: A life-threatening complication of Behçet's disease.

Echocardiography 2020 Jun 17. Epub 2020 Jun 17.

Department of Pediatric Cardiology, School of Medicine, Ankara University, Ankara, Turkey.

The incidence of multiple intra-cardiac masses is rare, and the differential diagnosis may be challenging sometimes. The most common etiologies of multiple intra-cardiac masses are thrombus, vegetation, and tumors. Intra-cardiac thrombus is more common in patients with central catheters, with a wall-motion abnormality and global hypokinesis. Read More

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http://dx.doi.org/10.1111/echo.14771DOI Listing

Sequencing of RNA in single cells reveals a distinct transcriptome signature of hematopoiesis in GATA2 deficiency.

Blood Adv 2020 Jun;4(12):2656-2670

Hematology Branch, National Heart, Lung, and Blood Institute.

Constitutional GATA2 deficiency caused by heterozygous germline GATA2 mutations has a broad spectrum of clinical phenotypes, including systemic infections, lymphedema, cytopenias, and myeloid neoplasms. Genotype-phenotype correlation is not well understood mechanistically in GATA2 deficiency. We performed whole transcriptome sequencing of single hematopoietic stem and progenitor cells from 8 patients, who had pathogenic GATA2 mutations and myelodysplasia. Read More

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http://dx.doi.org/10.1182/bloodadvances.2019001352DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7322959PMC

Uncoupling DNA damage from chromatin damage to detoxify doxorubicin.

Proc Natl Acad Sci U S A 2020 Jun 17;117(26):15182-15192. Epub 2020 Jun 17.

Department of Cell and Chemical Biology, ONCODE Institute, Leiden University Medical Center, 2333 ZC Leiden, The Netherlands;

The anthracycline doxorubicin (Doxo) and its analogs daunorubicin (Daun), epirubicin (Epi), and idarubicin (Ida) have been cornerstones of anticancer therapy for nearly five decades. However, their clinical application is limited by severe side effects, especially dose-dependent irreversible cardiotoxicity. Other detrimental side effects of anthracyclines include therapy-related malignancies and infertility. Read More

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http://dx.doi.org/10.1073/pnas.1922072117DOI Listing

Angiography and embolization of meningiomas.

Handb Clin Neurol 2020 ;169:193-202

Miami Neuroscience Institute, Baptist Health of South Florida, Miami, FL, United States; Division of Neuroscience, Herbert Wertheim College of Medicine, Florida International University, Miami, FL, United States.

The preoperative embolization of meningiomas has been part of the surgical treatment of large meningiomas for over 45 years. During that time there have been huge advances in the field of endovascular surgery with respect to techniques and instrumentation. Angiography and embolization are usually reserved for the largest tumors where there are concerns over potential blood loss with surgical excision. Read More

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http://dx.doi.org/10.1016/B978-0-12-804280-9.00013-5DOI Listing
January 2020

A case of pheochromocytoma presenting with cardiac manifestation: case report.

BMC Pediatr 2020 Jun 17;20(1):299. Epub 2020 Jun 17.

Cardiovascular Research Center, Shahid Madani Heart Center, Tabriz University of Medical Sciences, Tabriz, Iran.

Background: Pheochromocytomas are rare tumors originating in chromaffin cells which predominantly are located in adrenal glands. Sustained or paroxysmal hypertension (HT) is the most frequent sign of pheochromocytoma. In some cases, it is associated with the classic triad including episodic headaches, sudoresis, and tachycardia; however, we present a case of pheochromocytoma with first presentation of cardiomyopathy. Read More

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http://dx.doi.org/10.1186/s12887-020-02197-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7298960PMC

Cardiac Autotransplantation with Concurrent Pneumonectomy for Complete Resection of Primary Cardiac Intimal Sarcoma.

Korean J Thorac Cardiovasc Surg 2020 Jun;53(3):140-143

Department of Thoracic and Cardiovascular Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

Primary cardiac sarcoma is rare, and intimal sarcoma is an extremely rare and highly lethal disease. We report a case of a 62-year-old woman who was incidentally diagnosed with a primary cardiac sarcoma originating from the left atrial appendage and extending to the left superior pulmonary vein. The location of the tumor was very complicated, posing a major challenge for complete resection. Read More

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http://dx.doi.org/10.5090/kjtcs.2020.53.3.140DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7287220PMC

Failed primary percutaneous coronary intervention in a middle-aged man without cardiovascular risk factors: left atrium myxoma.

Pan Afr Med J 2020 6;36. Epub 2020 May 6.

Razi Clinical Research Development Unit (RCRDU), Birjand University of Medical Sciences, Birjand, Iran.

Embolic events are rare presentation of myxoma, which is one of the most prevalent benign cardiac tumors. Here we report the case of a 53-year-old man with presentation of acute anterior infarction and occlusion of the left anterior descending artery in association with left atrial myxoma. Intracoronary aspiration thrombectomy along with frequent balloon inflation was failed to recover distal coronary blood flow. Read More

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http://dx.doi.org/10.11604/pamj.2020.36.6.14845DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7282618PMC

Prediction of Submucosal Invasion for Gastric Neoplasms in Endoscopic Images Using Deep-Learning.

J Clin Med 2020 Jun 15;9(6). Epub 2020 Jun 15.

Division of Biomedical Informatics, Seoul National University Biomedical Informatics (SNUBI), Seoul National University College of Medicine, Seoul 03080, Korea.

Endoscopic resection is recommended for gastric neoplasms confined to mucosa or superficial submucosa. The determination of invasion depth is based on gross morphology assessed in endoscopic images, or on endoscopic ultrasound. These methods have limited accuracy and pose an inter-observer variability. Read More

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http://dx.doi.org/10.3390/jcm9061858DOI Listing

Primary Biatrial Cardiac Rhabdomyosarcoma.

Braz J Cardiovasc Surg 2020 Jun 1;35(3):399-401. Epub 2020 Jun 1.

Yamagata University Faculty of Medicine Second Department of Surgery Yamagata Japan Second Department of Surgery, Faculty of Medicine, Yamagata University, Yamagata, Japan.

Primary malignant neoplasms of the heart are rare. Cardiac rhabdomyosarcoma is the second most common primary sarcoma. We report a rare case of a 49-year-old woman with a huge biatrial cardiac rhabdomyosarcoma treated by performing surgical resection followed by salvage chemotherapy for local recurrence. Read More

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http://dx.doi.org/10.21470/1678-9741-2018-0414DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7299580PMC

Incidental discovery of right ventricular lipoma in a young female associated with ventricular hyperexcitability: An imaging multimodality approach.

World J Cardiol 2020 May;12(5):220-227

Cardiovascular Department, Institute CARDIOMET, Rangueil University Hospital, Toulouse 31400, France.

Background: Cardiac lipomas are rare benign tumors commonly found in the right atrium or left ventricle. Patients are usually asymptomatic, and clinical presentation depends on location and adjacent structures impairment. Right ventricle lipomas are scarce in the literature. Read More

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http://dx.doi.org/10.4330/wjc.v12.i5.220DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7284002PMC

Surgical treatment strategies for extra-pelvic intravenous leiomyomatosis.

Orphanet J Rare Dis 2020 Jun 16;15(1):153. Epub 2020 Jun 16.

Department of General Surgery, Zhongshan Hospital, Fudan University, No. 180 Fenglin Road, Shanghai, 200032, China.

Background: Extra-pelvic intravenous leiomyomatosis (IVL) extending into inferior vena cava (IVC) or heart (i.e. intracardiac leiomyomatosis, ICL) is an extremely rare benign disease. Read More

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http://dx.doi.org/10.1186/s13023-020-01394-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7296750PMC

[Gastrointestinal tumors in older patients].

Z Gastroenterol 2020 Jun 16;58(6):564-576. Epub 2020 Jun 16.

II. Medizinische Klinik, Universitätsmedizin Mannheim, Medizinische Fakultät, Universität Heidelberg.

Older patients (65 years and over) represent the majority of patients with a cancer diagnosis. For oesophageal carcinomas, the age peak is in the seventh to eighth decade of life. In gastric carcinoma, 1/3 of patients are older than 75 years and approximately 45 % of colon carcinoma patients are ≥ 75 years old. Read More

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http://dx.doi.org/10.1055/a-1149-2282DOI Listing

Papillary Fibroelastoma of the Right Ventricle in the Setting of Multifocal Pulmonary Hemorrhages and Pulmonary Embolization in a 39-Year-Old Man: A Case Report.

Am J Case Rep 2020 Jun 16;21:e923074. Epub 2020 Jun 16.

Department of Medicine, Arnot Ogden Medical Center, Elmira, NY, USA.

BACKGROUND Papillary fibroelastoma accounts for approximately 24% of all primary cardiac tumors and is the third most common primary cardiac neoplasm. It mostly involves the cardiac valves; however, there have been cases of involvement of the endocardium. Papillary fibroelastoma, although typically benign, can cause a plethora of complications, including systemic embolization, myocardial infarction, arrhythmia, and sudden cardiac death. Read More

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http://dx.doi.org/10.12659/AJCR.923074DOI Listing

Infantile hepatic hemangioendothelioma associated with pulmonary artery hypertension and cardiac insufficiency successfully treated with transcatheter arterial embolization and propranolol: A case report.

Medicine (Baltimore) 2020 Jun;99(24):e20728

Department of Vascular Anomalies and Interventional Radiology, Ji'nan Children's Hospital, Jinan.

Introduction: Infantile hepatic hemangioendothelioma is a type of benign hepatic tumor that occurs in infancy. Many hepatic tumors are diagnosed when screening is done for multiple cutaneous hemangiomas. Hepatic tumors are small multifocal lesions and are mostly asymptomatic. Read More

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http://dx.doi.org/10.1097/MD.0000000000020728DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7302649PMC