Search Our Scientific Publications & Authors

Blood 2021 Jun 14. Epub 2021 Jun 14.

IRCCS Humanitas Clinical Institute, Rozzano, Italy.

Clonal hematopoiesis of indeterminate potential (CHIP) is associated with increased risk of cancers and inflammation-related diseases. This phenomenon becomes very common in oldest-old individuals, in whom the implications of CHIP are not well defined. We performed a mutational screening in 1794 oldest-old individuals enrolled in two population-based studies and investigate the relationships between CHIP and associated pathologies. Read More

Front Cardiovasc Med 2021 28;8:676807. Epub 2021 May 28.

Department of Cardiovascular Surgery, The Second Xiangya Hospital, Central South University, Changsha, China.

Cardiac myxomas, primarily originating from the left atrium, are the most prevalent types of benign cardiac tumors; however, biatrial myxomas are extremely rare. Herein, we present a rare case of a 55-year old male with exertional dyspnea and intermittent chest discomfort due to a giant biatrial mass with concomitant atrial fibrillation and hepatic hemangioma. The giant tumor with its peduncle at the interatrial septum involved both atria; however, bulging through the tricuspid valve to the right ventricle during systole. Read More

Front Oncol 2021 27;11:645245. Epub 2021 May 27.

Department of Oncology, Beijing Friendship Hospital, Capital Medical University, Beijing, China.

Background: We performed a systematic review and meta-analysis to evaluate the risks of cardiac adverse events in solid tumor patients treated with monotherapy of immune checkpoint inhibitors (ICIs) or combined therapy of ICIs plus chemotherapy.

Methods: Eligible studies were selected through the following databases: PubMed, Embase and clinical trials (https://clinicaltrials.gov. Read More

J Contemp Brachytherapy 2021 Jun 14;13(3):302-309. Epub 2021 May 14.

Department of Radiation Oncology, Regional Cancer Centre, JIPMER, Puducherry, India.

Purpose: To dosimetrically compare high-dose-rate interstitial brachytherapy (HDR-BT) with volumetric-modulated arc therapy (VMAT) for tumor bed boost, following breast conservative treatment.

Material And Methods: 50 patients with early-stage breast cancer who underwent breast conservation surgery, followed by either HDR-BT ( = 25) of 15 Gy in 6 fractions over a period of 3 days, or VMAT dose of 16 Gy in 8 fractions ( = 25) for tumor bed boost, were retrospectively reviewed. All patients received whole breast irradiation of 46 Gy in 23 fractions. Read More

World J Surg Oncol 2021 Jun 12;19(1):173. Epub 2021 Jun 12.

Division of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Kamigyo-ku, Kyoto, 602-8566, Japan.

Background: Since inflammation and the immune system contribute to the development and progression of malignancies, parameters that reflect a host's immune-inflammatory status may be useful prognostic indicators of gastric cancer (GC). The present study examined the clinical significance of a preoperative systemic immune-inflammation index (SII) for predicting postoperative survival outcomes in GC.

Methods: A total of 447 patients who underwent curative gastrectomy for GC were included in the present study. Read More

Braz J Anesthesiol 2021 Jun 9. Epub 2021 Jun 9.

Hospital Universitari Son Espases, Cardiovascular Surgery, Quiron Clinica Rotger and Head of Service, Lead Consultant Cardiac Surgeon, Palma de Mallorca, Spain.

Introduction: Primary pleomorphic pulmonary angiosarcomas are extremely rare tumors which could be easily mistaken for pulmonary emboli.

Background And Findings: We describe the successful perioperative management of a patient with a pulmonary arterial mass which turned out to be a primary pulmonary angiosarcoma. The severe pulmonary hypertension was a particular challenge compounded with the site and adhesions of the tumor, and pulmonary hemorrhage. Read More

BMJ Case Rep 2021 Jun 11;14(6). Epub 2021 Jun 11.

Internal Medicine, University of Florida College of Medicine, Gainesville, Florida, USA.

Neuroendocrine tumours occur most frequently in the gastrointestinal tract, lungs, and pancreas. Primary malignant cardiac tumours are uncommon and are usually sarcomas, lymphomas, or, infrequently, mesotheliomas. Primary cardiac neuroendocrine carcinomas are exceedingly rare; only nine have been reported in the literature to date. Read More

Cancer Med 2021 Jun 11. Epub 2021 Jun 11.

Unit for Thrombosis and Drug Research, Department of Cardiology, Aalborg University Hospital, Aalborg, Denmark.

Background: Direct oral anticoagulants (DOACs) may increase the risk of gastrointestinal (GI) bleeding in patients with atrial fibrillation (AF) and GI cancer compared with vitamin K antagonists (VKA).

Methods: We conducted a Danish nationwide cohort study comparing the bleeding risk associated with DOAC versus VKA in patients with AF and GI cancer. We calculated crude bleeding rates per 100 person-years (PYs) for GI and major bleeding. Read More

Endocrinol Metab (Seoul) 2021 Jun 10. Epub 2021 Jun 10.

Division of Endocrinology and Metabolism, Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.

Background: Decreased heart rate variability (HRV) has been reported to be associated with cardiac autonomic dysfunction. Hypopituitarism in nonfunctioning pituitary adenoma (NFPA) is often linked to increased cardiovascular mortality. We therefore hypothesized that postoperative NFPA patients with hormone deficiency have an elevated risk of HRV alterations indicating cardiac autonomic dysfunction. Read More

Endocrinol Metab (Seoul) 2021 Jun 10. Epub 2021 Jun 10.

Department of Internal Medicine, Biomedical Research Institute, Pusan National University Hospital, Busan, Korea.

Background: We aimed to evaluate the clinicopathological features and biological behaviors of Korean thyroid cancer patients with rare variants of papillary thyroid carcinoma (PTC) to address the ambiguity regarding the prognostic consequences of these variants.

Methods: We retrospectively reviewed the medical records of 5,496 patients who underwent thyroid surgery for PTC, between January and December 2012, in nine tertiary hospitals. Rare PTC variants included tall cell (TCV), columnar cell (CCV), diffuse sclerosing (DSV), cribriform-morular (CMV), solid (SV), hobnail, and Warthin-like variants. Read More

Pan Afr Med J 2021 11;38:255. Epub 2021 Mar 11.

Faculté de Médecine d'Antananarivo, Antananarivo, Madagascar.

The management of breast cancer during pregnancy is a challenge for physicians due to mother´s desire to carry the pregnancy to term despite the need for chemotherapy. This study reports the case of a 37-year-old multiparous woman at 20 weeks and 4 days of amenorrhea (WA). She was hospitalized for dyspnoea (stage IV according to New York Heart Association (NYHA) classification). Read More

Ann Pediatr Cardiol 2021 Apr-Jun;14(2):224-227. Epub 2021 Apr 10.

Pediatric Cardiology Unit, Virgen del Rocío University Hospital/Institute of Biomedicine of Sevilla (IBIS) of Seville, CIBER-CV, Seville, Spain.

Cardiac fibromas (CF) are the second most common cardiac tumors in children. They can be aggressive tumors despite their benign histopathologic nature, accounting for the highest mortality rate among primary cardiac tumors. CF usually show a progressive growth and spontaneous regression is rare. Read More

J Cardiothorac Surg 2021 Jun 7;16(1):164. Epub 2021 Jun 7.

Department of Cardiovascular Surgery, Chinese PLA General Hospital, No.28. Fuxing Road, Haidian District, Beijing, 100853, China.

Background: Intracardiac blood cysts are very rare primary cardiac tumors. Blood cysts originated from the mitral valve represent a minority of cases, and previous cases have been mainly treated with conventional surgery through median sternotomy. When the tumor involves heart valves and histopathological diagnosis remains unknown preoperatively, minimally invasive surgical resection of an intracardiac tumor can be challenging, especially through an endoscopic approach. Read More

Am J Case Rep 2021 Jun 7;22:e932239. Epub 2021 Jun 7.

Department of Surgery, National Hospital Organization Higashihiroshima Medical Center, Hiroshima, Japan.

BACKGROUND Malignant tumors, such as lung and breast cancers, can metastasize to the heart. However, cardiac metastasis rarely occurs in colorectal cancer. Cardiac metastasis cases are typically asymptomatic and rarely cause cardiac tamponade. Read More

J Card Surg 2021 Jun 6. Epub 2021 Jun 6.

Department of Internal Medicine, Louisiana State University Health Sciences Center, Shreveport, Louisiana, USA.

Mitochondrion 2021 Jun 4;59:175-183. Epub 2021 Jun 4.

Neurophysiology Unit, Cardiac Electrophysiology Research and Training Center, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand; Center of Excellence in Cardiac Electrophysiology Research, Chiang Mai University, Chiang Mai 50200, Thailand; Department of Oral Biology and Diagnostic Sciences, Faculty of Dentistry, Chiang Mai University, Chiang Mai 50200, Thailand. Electronic address:

We aimed to compare mitochondrial function, mitochondrial dynamics, apoptosis, and necroptosis between odontogenic cysts/tumors, including radicular cysts, dentigerous cysts, ameloblastoma, vs. dental follicles as control. We demonstrated that mitochondrial dysregulation and imbalanced mitochondrial dynamics were observed in ameloblastoma. Read More

Int J Surg Case Rep 2021 Jun 1;83:106057. Epub 2021 Jun 1.

Department of Urology, Aleppo University Hospital, Aleppo, Syria. Electronic address:

Introduction And Importance: Bladder diverticula are mucosal outpunching of the bladder without a muscle layer. It could be detected incidentally or by giving symptoms of its complications.

Case Presentation: A 59-year-old male patient presented with painless gross hematuria. Read More

Medicine (Baltimore) 2021 Jun;100(22):e26152

Department of Anesthesiology and Pain Medicine, Hanyang University Medical Center, Hanyang University College of Medicine, Seoul, Korea.

Rationale: Patients with cancer have elevated risk of both venous thromboembolism and bleeding compared with patients without cancer due to cancer- and patient-specific factors. Balancing the increased and competing risks of clotting and bleeding in these patients can be difficult because management of cancer-associated thrombosis requires anticoagulation despite its known increased risks for bleeding. The adjustment of blood transfusion or cessation of anticoagulants can be a challenge in surgical diagnosis or treatment of cancer patients with such an imbalanced coagulate status. Read More

J Gynecol Oncol 2021 Jul;32(4):e65

Department of Clinical Epidemiology and Biostatistics, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

Objective: Investigation of new drugs (INDs) is a tremendously inefficient process in terms of time and cost. Drug repositioning is another method used to investigate potential new agents in well-known drugs. This study assessed the survival impact of metformin medication on ovarian cancer. Read More

Clin Case Rep 2021 May 4;9(5):e04029. Epub 2021 May 4.

Department of Cardiology Faculty of Medicine School of Health Sciences University of Thessaly Larissa Greece.

Although myxoma represents the most frequent non-malignant cardiac primary tumor; it is extremely rare met in the left ventricle. Clinical features of the neoplasm extend from symptomless to critical signs of either ischemia or embolism. We describe here an unusual case of a huge left ventricular myxoma in a 68-year-old man, presented with clinical and ECG findings of an inferior wall myocardial infarction. Read More

BMJ Case Rep 2021 Jun 2;14(6). Epub 2021 Jun 2.

Cardiac Surgery, Jikei University School of Medicine, Minato-ku, Tokyo, Japan.

A 60-year-old man was referred to our hospital because of chest tightness. CT scans showed no specific findings except a right ventricular (RV) mass. Echocardiogram revealed that the large cardiac mass was compressing the right ventricular outflow tract, and the patient thus underwent an emergency operation. Read More

Rev Med Liege 2021 May;76(5-6):559-564

Service de Psychologie clinique et d'Action sociale, CHU Liège, Belgique.

Although conventional medicine has made considerable progress in the treatment of cancer, this disease remains a distressing experience for patients who may feel they are losing control of their live. In response to this need for autonomy over their therapeutic choices and their health, some patients turn to complementary and alternative medicine. Some oncology care centres therefore complete their offer of care by providing patients with a well-being centre where activities focusing on the well-being and comfort of the person are offered. Read More

Rev Med Liege 2021 May;76(5-6):300-306

Président du Conseil de Gouvernance de l'Institut de Cancérologie Arsène Burny (ICAB); Service d'Hématologie, CHU Liège, Belgique.

The Arsène Burny Cancer Institute (ICAB) of the CHU de Liège is the reference university medical center, open to its environment, dedicated to cancer care. Transversality, academic expertise, quality of care and direct links with research are at the heart of this ambitious achievement, which is much more than a building. The Integrated Center of Oncology (CIO) is the new ICAB building, dedicated to outpatient cancer care and high performance technical platforms such as radiotherapy with its Cyberknife, oncology imaging with its radiopharmacy, the Laboratory of Cell and Gene Therapy, the Liège University Hospital Biobank, or the laboratories grouped together within Unilab, while hospitalizations remain in the existing towers of the CHU. Read More

Cureus 2021 Apr 17;13(4):e14537. Epub 2021 Apr 17.

Internal Medicine, Interfaith Medical Center, Brooklyn, USA.

Renal cell carcinoma (RCC) can invade locally through the renal vein and into the inferior vena cava (IVC) with tumor-thrombus formation reported in 5%-15% of patients. From the IVC, RCC can grow intravascularly and extend into the right atrium. We present a rare case with two uncommon findings: tumor-thrombus extension leading to a right atrial mass and initial presentation of RCC as heart failure. Read More

Arterioscler Thromb Vasc Biol 2021 Jun 3:ATVBAHA121316300. Epub 2021 Jun 3.

Division of Cardiovascular Medicine, University of Massachusetts Medical School, Worcester. (R.J., H.P.J., C.M.T.).

Acute Crit Care 2021 May 28;36(2):164-168. Epub 2021 May 28.

Department of Pediatrics, Chonnam National University Children's Hospital, Gwangju, Korea.

Pediatric cardiac tumors are rare. Among these, cardiac fibroma is the second most common. Its clinical manifestations depend on size and location of the tumor and include arrhythmia or obstruction to blood flow. Read More

Cancers (Basel) 2021 May 18;13(10). Epub 2021 May 18.

Department of Biology, Genetic Unit, University of Pisa, via Derna 1, 56126 Pisa, Italy.

Background: Malignant pleural mesothelioma (MPM) is a fatal tumor with a poor prognosis. The recent developments of liquid biopsies could provide novel diagnostic and prognostic tools in oncology. However, there is limited information about the feasibility of this technique for MPMs. Read More

Cancers (Basel) 2021 May 14;13(10). Epub 2021 May 14.

School of Allergy and Clinical Immunology, Department of Clinical and Experimental Medicine, University of Messina, 98125 Messina, Italy.

Benzene carcinogenic ability has been reported, and chronic exposure to benzene can be one of the risk elements for solid cancers and hematological neoplasms. Benzene is acknowledged as a myelotoxin, and it is able to augment the risk for the onset of acute myeloid leukemia, myelodysplastic syndromes, aplastic anemia, and lymphomas. Possible mechanisms of benzene initiation of hematological tumors have been identified, as a genotoxic effect, an action on oxidative stress and inflammation and the provocation of immunosuppression. Read More

Cancers (Basel) 2021 May 12;13(10). Epub 2021 May 12.

Department of Surgery, Oncology and Gastroenterology, Veneto Institute of Oncology IOV-IRCCS, University of Padova, 35128 Padova, Italy.

Plexiform neurofibromas (Pnfs) are benign peripheral nerve sheath tumors that are major features of the human genetic syndrome, neurofibromatosis type 1 (NF1). Pnfs are derived from Schwann cells (SCs) undergoing loss of heterozygosity (LOH) at the locus in an milieu and thus are variably lacking in the key Ras-controlling protein, neurofibromin (Nfn). As these SCs are embedded in a dense desmoplastic milieu of stromal cells and abnormal extracellular matrix (ECM), cell-cell cooperativity (CCC) and the molecular microenvironment play essential roles in Pnf progression towards a malignant peripheral nerve sheath tumor (MPNST). Read More

Diagnostics (Basel) 2021 May 3;11(5). Epub 2021 May 3.

Department of Emergency and Organ Transplantation, Section of Pathology, University of Bari "Aldo Moro", 70124 Bari, Italy.

Mesonephric adenocarcinomas are rare tumors of the female genital tract, thought to arise from embryonic mesonephric remnants, primarily in the cervix and vagina. Conversely, endometrial and ovarian mesonephric adenocarcinomas may have a different pathogenesis, probably originating from transdifferentiated Müllerian carcinomas, as demonstrated by the association of these neoplasms with endometriosis and ovarian serous tumors. For this reason, in the endometrium and in the ovary, they are defined as "mesonephric-like adenocarcinomas". Read More