5,301 results match your criteria Cardiac Sarcoma

Doxorubicin-Dexrazoxane from Day 1 for Soft-tissue Sarcomas: The Road to Cardioprotection.

Clin Cancer Res 2021 May 14. Epub 2021 May 14.

Department of Medicine, Center for Integrated Research and Unit of Drug Sciences, University Campus Bio-Medico.

Doxorubicin cardiac toxicity is widely misunderstood, largely preventable, and starts with the first dose. This paper reviews the history of doxorubicin cardiac toxicity and strategies for minimizing it. Dexrazoxane cardioprotection can safely be initiated on day 1 without compromising antitumor activity, allowing doxorubicin administration beyond the reported maximum lifetime dose. Read More

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Heart Failure With Targeted Cancer Therapies: Mechanisms and Cardioprotection.

Circ Res 2021 May 13;128(10):1576-1593. Epub 2021 May 13.

Penn Cardio-Oncology Translational Center of Excellence, Abramson Cancer Center (L.S., V.N., B.K.), Perelman School of Medicine, University of Pennsylvania, Philadelphia.

Oncology has seen growing use of newly developed targeted therapies. Although this has resulted in dramatic improvements in progression-free and overall survival, challenges in the management of toxicities related to longer-term treatment of these therapies have also become evident. Although a targeted approach often exploits the differences between cancer cells and noncancer cells, overlap in signaling pathways necessary for the maintenance of function and survival in multiple cell types has resulted in systemic toxicities. Read More

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Right atrial synovial sarcoma with thrombocytopenia: A deceptive presentation.

J Card Surg 2021 May 12. Epub 2021 May 12.

Department of Cardiac Surgery, CIMS Hospital, Ahmedabad, Gujarat, India.

Introduction: Primary cardiac synovial sarcoma is an exceedingly rare soft tissue malignant tumor, involving either the pericardium or chambers, with a striking male predominance, prevalently seen in the fourth decade. These tumours most commonly present as breathlessness on exertion. These patients readily exhibit gastrointestinal and systemic symptoms but sometimes the presentation can be fallacious. Read More

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Increased risk of secondary lung cancer in patients with tuberculosis: A nationwide, population-based cohort study.

PLoS One 2021 7;16(5):e0250531. Epub 2021 May 7.

Division of Clinical Pathology, Department of Pathology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.

Background: Tuberculosis (TB) presents a global threat in the world and the lung is the frequent site of metastatic focus. A previous study demonstrated that TB might increase primary lung cancer risk by two-fold for more than 20 years after the TB diagnosis. However, no large-scale study has evaluated the risk of TB and secondary lung cancer. Read More

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Cardiac safety of trabectedin monotherapy or in combination with pegylated liposomal doxorubicin in patients with sarcomas and ovarian cancer.

Cancer Med 2021 May 7. Epub 2021 May 7.

Sarcoma Center, Department of Medical Oncology, Dana-Farber Cancer Institute (DFCI), Harvard Medical School and Ludwig Center at Harvard, Boston, MA, USA.

Background: As with other alkylating agents, cardiac dysfunction can occur with trabectedin therapy for advanced soft tissue sarcomas (STS) or recurrent ovarian cancer (ROC) where treatment options for advanced disease are still limited. Cardiac safety for trabectedin monotherapy (T) for STS or in combination with pegylated liposomal doxorubicin (T+PLD) for ROC was evaluated in this retrospective postmarketing regulatory commitment.

Methods: Patient data for multiple cardiac-related treatment-emergent adverse events (cTEAEs) were evaluated in pooled analyses of ten phase 2 trials, one phase 3 trial in STS (n = 982), and two phase 3 trials in ROC (n = 1231). Read More

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Right ventricular undifferentiated pleomorphic sarcoma: A case report.

Ann Card Anaesth 2021 Jan-Mar;24(1):102-104

Department of Nursing, Neyshabur University of Medical Science, Neyshabur, Iran.

In this paper, a case of undifferentiated pleomorphic sarcoma in a patient with right-sided heart failure has been explored. A 61-year-old woman complaining from cough and dyspnea for a week following indistinctive surgery on right buttock area with reported pathology of malignant undifferentiated tumor presented to the hospital. Laboratory results indicated negative TPi enzyme and D. Read More

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A new-onset pulmonary artery stenosis in a young man: case report.

Eur Heart J Case Rep 2021 Apr 24;5(4):ytab118. Epub 2021 Apr 24.

Cardiothoracovascular Department, Azienda Ospedaliero-Universitaria Careggi and University of Florence, Largo Brambilla 3, 50134 Florence, Italy.

Background : Poorly differentiated and undifferentiated sarcomas are the most common primary tumours of the pulmonary arteries. They usually affect large-calibre vessels and present with predominantly intraluminal growth. Dyspnoea, cough, chest pain, and haemoptysis are the most common presenting symptoms. Read More

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Angiofibromatoid histiosarcoma of the pulmonary artery.

J Surg Case Rep 2021 Apr 24;2021(4):rjab132. Epub 2021 Apr 24.

Cardiothoracic Surgical Department, Royal Prince Alfred Hospital, Sydney, Australia.

We describe the surgical management of a rare pulmonary angiomatoid fibrous histiosarcoma (AFH). A 62-year-old lady presented with shortness of breath and found to have a large left main pulmonary artery defect that was positron emission tomography-avid. Following discussion in a thoracic multidisciplinary team meeting it was deemed unsafe to biopsy considering its intravascular position. Read More

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[Primary osteosarcoma of left atrium: report of a case].

Zhonghua Bing Li Xue Za Zhi 2021 May;50(5):524-526

Department of Pathology, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.

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Intimal Sarcoma: An Extremely Rare Case of a Left Atrial Tumor with Partial Obstruction of the Mitral Orifice.

CASE (Phila) 2021 Apr 5;5(2):93-96. Epub 2021 Feb 5.

Department of Cardiovascular Medicine, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Japan.

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Primary effusion lymphoma occurring in the setting of transplanted patients: a systematic review of a rare, life-threatening post-transplantation occurrence.

BMC Cancer 2021 Apr 27;21(1):468. Epub 2021 Apr 27.

Pathology Unit, Azienda Ospedaliera Santa Maria di Terni, University of Perugia, 05100, Terni, Italy.

Background: Primary effusion lymphoma is a rare, aggressive large B-cell lymphoma strictly linked to infection by Human Herpes virus 8/Kaposi sarcoma-associated herpes virus. In its classic form, it is characterized by body cavities neoplastic effusions without detectable tumor masses. It often occurs in immunocompromised patients, such as HIV-positive individuals. Read More

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Fus knockdown inhibits the profibrogenic effect of cardiac fibroblasts induced by angiotensin II through targeting Pax3 thereby regulating TGF-β1/Smad pathway.

Bioengineered 2021 Dec;12(1):1415-1425

Department of Cardiology, The People's Hospital, Chongqing, China.

The Angiotensin II/transforming growth factor-β1 (AngII/TGF-β1) signal axis is an important regulatory pathway for atrial fibrosis, which can contribute to atrial fibrillation (AF). Fused in sarcoma (FUS) was recently found to regulate cardiac diseases. This study aimed to investigate whether FUS could regulate AngII induced fibrosis and uncover the possible mechanisms. Read More

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December 2021

Metastatic Cardiac Tumor Presenting as an Anteroseptal ST-Segment Elevation Myocardial Infarction in a Young Male.

Cureus 2021 Mar 18;13(3):e13981. Epub 2021 Mar 18.

Department of Cardiology, Brooke Army Medical Center, San Antonio, USA.

In the appropriate clinical context, ST-segment elevation on electrocardiogram (ECG) necessitates prompt evaluation for coronary artery occlusion requiring reperfusion with percutaneous coronary intervention. Conversely, the etiology of ST-segment elevation may be representative of an alternative diagnosis other than myocardial infarction. We report the case of a patient with a history of primary bone sarcoma who presented for further evaluation of a large pericardial effusion identified on an outpatient echocardiogram and was found to have ST-segment elevation on ECG in the absence of any cardiopulmonary symptoms. Read More

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Drosophila RASopathy models identify disease subtype differences and biomarkers of drug efficacy.

iScience 2021 Apr 13;24(4):102306. Epub 2021 Mar 13.

Department of Cell, Developmental, and Regenerative Biology, Icahn School of Medicine at Mount Sinai, New York NY, USA.

RASopathies represent a family of mostly autosomal dominant diseases that are caused by missense variants in the rat sarcoma viral oncogene/mitogen activated protein kinase (RAS/MAPK) pathway including KRAS, NRAS, BRAF, RAF1, and SHP2. These variants are associated with overlapping but distinct phenotypes that affect the heart, craniofacial, skeletal, lymphatic, and nervous systems. Here, we report an analysis of 13 Drosophila transgenic lines, each expressing a different human RASopathy isoform. Read More

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A Survey of Compound Heterozygous Variants in Pediatric Cancers and Structural Birth Defects.

Front Genet 2021 22;12:640242. Epub 2021 Mar 22.

Department of Biology, Brigham Young University, Provo, UT, United States.

Compound heterozygous (CH) variants occur when two recessive alleles are inherited and the variants are located at different loci within the same gene in a given individual. CH variants are important contributors to many different types of recessively inherited diseases. However, many studies overlook CH variants because identification of this type of variant requires knowing the parent of origin for each nucleotide. Read More

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FUS/TLS suppresses enterovirus replication and promotes antiviral innate immune responses.

J Virol 2021 Apr 7. Epub 2021 Apr 7.

Centre for Heart and Lung Innovation, St. Paul's Hospital, University of British Columbia, Vancouver, BC, Canada

During viral infection, the dynamic virus-host relationship is constantly in play. Many cellular proteins such as RNA-binding proteins (RBPs) have been shown to mediate antiviral responses during viral infection. Here we reported that the RBP, fused in sarcoma/translocated in liposarcoma (FUS/TLS), acts as a host restricting factor against the infection of coxsackievirus B3 (CVB3). Read More

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Primary pulmonary artery sarcoma concomitant with chronic thromboembolism: role of 18F-FDG PET/CT.

Eur Heart J Cardiovasc Imaging 2021 Apr 7. Epub 2021 Apr 7.

Nanfang PET Center, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.

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Long-term follow-up of high-risk neuroblastoma survivors treated with high-dose chemotherapy and stem cell transplantation rescue.

Bone Marrow Transplant 2021 Apr 6. Epub 2021 Apr 6.

Département de Cancérologie de l'Enfant et de l'Adolescent, Gustave Roussy, Villejuif, France.

Intensive treatments including high-dose chemotherapy (HDC) with autologous stem cell rescue have improved high-risk neuroblastoma (HRNB) survival. We report the long-term health status of 145 HRNB survivors, alive and disease-free 5 years post HDC. Median follow-up was 15 years (range = 5-34). Read More

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Cytoreductive surgical resection of a rare pulmonary artery intimal sarcoma involving the pulmonary valve and right ventricle: a case report.

J Surg Case Rep 2021 Mar 29;2021(3):rjab051. Epub 2021 Mar 29.

Department of Cardiothoracic Surgery, Royal Prince Alfred Hospital, Sydney, Australia.

Pulmonary artery intimal sarcoma (PAIS) is an extremely rare malignant tumour. It is often misdiagnosed as chronic pulmonary thromboembolism. We describe a complex case in a 70-year-old man with PAIS extending into his right ventricle undergoing salvage cytoreductive surgical resection utilizing bivalirudin for cardiopulmonary bypass anticoagulation due to heparin-induced thrombocytopenia and thrombosis syndrome. Read More

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Surgical and multimodality treatment of cardiac sarcomas: A systematic review and meta-analysis.

J Card Surg 2021 Apr 2. Epub 2021 Apr 2.

Department of Thoracic and Cardiovascular Surgery, West German Heart and Vascular Center Essen, University Hospital of Essen, University Duisburg-Essen, Essen, Germany.

Introduction: Primary cardiac sarcomas (PCSs) are an extremely rare and aggressive type of malignancies that have been described only by a limited number of observational studies. This study aimed to evaluate the currently existing evidence comparing surgical to multimodality treatment of PCS.

Methods: We systematically reviewed Embase, MEDLINE, Cochrane Database, and Google Scholar, from inception to December 2020, for original articles about surgical and multimodality treatment of PCS. Read More

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Sarcoma of the Heart Treated with Stereotactic MR-Guided Online Adaptive Radiation Therapy.

Case Rep Oncol 2021 Jan-Apr;14(1):453-458. Epub 2021 Mar 12.

Department of Radiation Oncology, University Medical Center Utrecht, Utrecht, The Netherlands.

We present the first case in the literature of a patient with a histology-proven intimal sarcoma of the heart, recurrent after surgery, treated with stereotactic MR-guided online adaptive radiation therapy on an MR-Linac machine. The treatment was feasible and well tolerated. The CT scan 6 months after the last treatment showed stable disease. Read More

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Stanford parameters stratify the risk of recurrence in gynecologic smooth muscle tumors of uncertain malignant potential.

APMIS 2021 Jun 13;129(6):283-290. Epub 2021 Apr 13.

Anatomic Pathology Unit, Department of Advanced Biomedical Sciences, School of Medicine, University of Naples Federico II, Naples, Italy.

Smooth muscle tumor of uncertain malignant potential (STUMP) is an ill-defined category of neoplasms, which represent a diagnostic challenge. We aimed to assess whether the Stanford parameters, that is, high mitotic index (≥10/10HPF), significant atypia (moderate-to-severe), and coagulative tumor cell necrosis (CTCN), even when focal or ambiguous, may be used to stratify the risk of recurrence in gynecological smooth muscle tumor of uncertain malignant potential (STUMP). Electronic databases were searched from their inception to October 2019. Read More

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Cardiac Myeloid Sarcoma: Multimodal Imaging and Histopathologic Findings.

Radiol Cardiothorac Imaging 2021 Feb 11;3(1):e200540. Epub 2021 Feb 11.

Department of Diagnostic and Interventional Radiology (A.I., D.D., J.A.L.) and Department of Pathology (G.K.), University Hospital Bonn, Venusberg-Campus 1, 53127 Bonn, Germany; and Quantitative Imaging Laboratory Bonn (QILaB), Bonn, Germany (A.I., D.D., J.A.L.).

Supplemental material is available for this article. Read More

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February 2021

MR-guided stereotactic body radiation therapy for primary cardiac sarcomas.

Radiat Oncol 2021 Mar 26;16(1):60. Epub 2021 Mar 26.

Department of Bioimaging, Radiation Oncology and Hematology, Fondazione Policlinico Universitario "A. Gemelli" IRCCS, Rome, Italy.

Background: Primary cardiac tumors are an extremely rare disease with limited prognosis. The treatment of choice is surgery. Other treatment options include chemotherapy and radiation therapy, which historically represented a palliative approach in patients who were not eligible for surgery. Read More

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Donor-derived human herpesvirus 8 infection with Kaposi sarcoma and Kaposi sarcoma inflammatory cytokine syndrome in a heart transplant recipient: A case report.

Transpl Infect Dis 2021 Mar 26:e13609. Epub 2021 Mar 26.

Heart Failure and Transplant Program, Cardiology Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna Policlinico S Orsola-Malpighi, University of Bologna, Bologna, Italy.

Human herpesvirus-8 (HHV-8) infection is associated with neoplastic and non-neoplastic diseases in immunocompromised patients. Kaposi sarcoma (KS) is a common malignancy reported in solid organ transplant recipients (SOTR). Kaposi sarcoma inflammatory cytokine syndrome (KICS), initially described in HIV patients, is characterized by high viral loads, elevated levels of cytokines, cytopenia, high fever, organ failure, and poor outcome. Read More

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Interim Analysis of the Phase II Study: Noninferiority Study of Doxorubicin with Upfront Dexrazoxane plus Olaratumab for Advanced or Metastatic Soft-Tissue Sarcoma.

Clin Cancer Res 2021 Mar 25. Epub 2021 Mar 25.

Cardio-Oncology Center of Excellence, Washington University in St. Louis, St. Louis, Missouri.

Purpose: To report the interim analysis of the phase II single-arm noninferiority trial, testing the upfront use of dexrazoxane with doxorubicin on progression-free survival (PFS) and cardiac function in soft-tissue sarcoma (STS).

Patients And Methods: Patients with metastatic or unresectable STS who were candidates for first-line treatment with doxorubicin were deemed eligible. An interim analysis was initiated after 33 of 65 patients were enrolled. Read More

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Myeloid sarcoma diagnosed on pleural effusion cytology: A case report and literature review.

Diagn Cytopathol 2021 Mar 22. Epub 2021 Mar 22.

Department of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, South Carolina, USA.

Myeloid sarcoma (MS) is a mass-forming, extramedullary infiltration of myeloid blasts rarely presenting in cases of acute myeloid leukemia (AML). These tumoral masses rarely occur at any and multiple anatomic sites, precedent or coincident with bone marrow evidence of AML. We report a case of MS that presented as pancreatic and cardiac masses where subsequent evaluation of pleural effusion cytology rendered the diagnosis. Read More

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Metastatic intrapulmonary hemorrhagic foci secondary to cardiac angiosarcoma: a case report.

BMC Surg 2021 Mar 9;21(1):125. Epub 2021 Mar 9.

Department of Thoracic Surgery, West China Hospital, Sichuan University, West China Hospital 37 Guoxue Lane, Wuhou District, Chengdu, 610000, Sichuan, China.

Background: Cardiac angiosarcoma is a very rare malignant neoplasm, typically showing terrible prognosis. Therefore, early diagnosis is essential for efficacious intervention. Here we report a cardiac angiosarcoma with unique imaging findings because of pulmonary metastases. Read More

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Resection of primary cardiac angiosarcoma infiltrating the right atrioventricular junction and tricuspid valve: a case report.

J Cardiothorac Surg 2021 Mar 21;16(1):41. Epub 2021 Mar 21.

Department of Cardiac Surgery, Faculty of Medicine, Damascus University, Damascus, Syria.

Background: Primary cardiac tumours are extremely rare. Most of them are benign. Sarcomas account for 95% of the malignant tumours. Read More

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