4,876 results match your criteria Cardiac Sarcoma


Total artificial heart implantation after right ventricular intimal spindle cell sarcoma.

Eur J Cardiothorac Surg 2019 Apr 21. Epub 2019 Apr 21.

Department of Cardiothoracic Transplantation and Mechanical Circulatory Support, Royal Brompton and Harefield NHS Foundation Trust, London, UK.

This paper describes the case of a patient with a high-grade spindle sarcoma in the right ventricle. The patient underwent total cardiectomy followed by the implantation of a total artificial heart. The patient had an uneventful postoperative course and remained tumour-free for 12 months; after that time period she underwent a heart transplant. Read More

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http://dx.doi.org/10.1093/ejcts/ezz117DOI Listing

Human Herpes-8 virus copy to cell ratio: A diagnostic tool in primary effusion lymphoma.

J Clin Virol 2019 Mar 22;116:7-10. Epub 2019 Mar 22.

Virus Reference Department, National Infection Service, Public Health England, 61 Colindale Ave, London, NW9 5HT, United Kingdom. Electronic address:

Primary effusion lymphoma (PEL) is a serious sequel to Human Herpes Virus 8 (HHV8) infection in the immunosuppressed host. Usually requiring a cytological diagnosis, body cavity effusions are often referred for investigation for possible PEL. Although absence of HHV8 effectively refutes this, the presence of HHV8 DNA, though indicative is not diagnostic. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S13866532193006
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http://dx.doi.org/10.1016/j.jcv.2019.03.013DOI Listing
March 2019
2 Reads

Intimal sarcoma of the inferior vena cava with extension to the right atrium, bilateral renal vasculature, and bilateral venae iliaca communis, accompanied by severe thrombocytopenia.

J Card Surg 2019 Apr 13. Epub 2019 Apr 13.

Department of Cardiac Surgery, Peking University People's Hospital, Bejing, China.

A 66-year-old Asian female diagnosed with an occupied mass of the inferior vena cava (IVC) case with extension to the right atrium, bilateral renal vasculature, and venae iliaca communis, which caused severe thrombocytopenia and severe liver and kidney dysfunction. The postoperative pathological diagnosis was high-grade undifferentiated intimal sarcoma. There have been less than 10 cases of venous undifferentiated intimal sarcomas reported in the literature, three of which occurred in the IVC. Read More

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http://dx.doi.org/10.1111/jocs.14049DOI Listing
April 2019
1 Read

The impact of severe late-effects after 12 Gy fractionated total body irradiation and allogeneic stem cell transplantation for childhood leukemia (1988-2010).

Pediatr Hematol Oncol 2019 Apr 12:1-17. Epub 2019 Apr 12.

c Host Research Team EA4607 SNA-EPIS, PRES Lyon, Jean Monnet University, University Hospital , Saint-Etienne , France.

This study consists of a retrospective study including 71 childhood leukemia survivors (36 females) treated with allo-HSCT 12 Gy fractionated total body irradiation (fTBI) conditioning, with a median age of 25.0 y at time of follow-up and a median delay of 14.8 y since the graft. Read More

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http://dx.doi.org/10.1080/08880018.2019.1591549DOI Listing
April 2019
1 Read

Primary Cardiac Sarcoma: A Rare, Aggressive Malignancy with a High Propensity for Brain Metastases.

Sarcoma 2019 10;2019:1960593. Epub 2019 Mar 10.

Department of Internal Medicine, University of Michigan, 1500 E Medical Center Drive, Ann Arbor, MI 48109, USA.

Introduction: Primary cardiac sarcoma (PCS) has a poor prognosis compared to other sarcomas due to late presentation, challenging resection, incidence of metastases, and limited efficacy of systemic therapies.

Methods: A medical record search engine was queried to identify patients diagnosed with PCS from 1992 to 2017 at the University of Michigan.

Results: Thirty-nine patients with PCS had a median age of 41 years (range 2-77). Read More

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http://dx.doi.org/10.1155/2019/1960593DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431449PMC
March 2019
1 Read

Multicenter phase II clinical trial of isolated lung perfusion in patients with lung metastases.

Ann Thorac Surg 2019 Apr 2. Epub 2019 Apr 2.

ASTARC, University of Antwerp, Wilrijk, Belgium; Department of Thoracic and Vascular Surgery, Antwerp University Hospital, Edegem, Belgium.

Background: Up to 66% of patients show local pulmonary disease progression after pulmonary metastasectomy. Regional treatment with isolated lung perfusion (ILuP) may improve local control with minimal systemic side-effects. The aim of this study is to evaluate local and distant control after ILuP and to determine the effect on overall survival in comparison with historical controls. Read More

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http://dx.doi.org/10.1016/j.athoracsur.2019.02.071DOI Listing
April 2019
2 Reads

A case of pulmonary artery sarcoma that was initially mis-diagnosed as pulmonary embolism.

J Surg Case Rep 2019 Mar 29;2019(3):rjz078. Epub 2019 Mar 29.

Department of Cardiac Surgery, Asahikawa Medical University, Midorigaoka Higashi 2-1-1-1, Asahikawa, Hokkaido, Japan.

Pulmonary artery sarcoma is a rare and highly malignant neoplasm. Early diagnosis and a multidisciplinary approach including surgical treatment and optimal medical therapy could prolong survival. Since the clinical symptoms and imaging findings of pulmonary artery sarcoma mimic pulmonary embolism, definitive diagnosis and surgical intervention are often delayed. Read More

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http://dx.doi.org/10.1093/jscr/rjz078DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6439511PMC
March 2019
1 Read

Multidisciplinary Assessment of Planning and Resection of Complex Bone Tumor Using Patient-Specific 3D Model.

Indian J Surg Oncol 2019 Mar 5;10(1):115-124. Epub 2018 Dec 5.

1Department of Orthopedic Surgery, Faculty of Medicine, Ege University, Izmir, Turkey.

Oncological interventions in thoracic cavity have some important problems such as choice of correct operative approaches depending on the tumor, size, extension, and location. In sarcoma surgery, wide resection should be aimed for the curative surgery. Purpose of this study was to evaluate pre-operative planning of patient-specific thoracic cavity model made by multidisciplinary surgeon team for complex tumor mass for oncological procedures. Read More

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http://link.springer.com/10.1007/s13193-018-0852-5
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http://dx.doi.org/10.1007/s13193-018-0852-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6414570PMC
March 2019
7 Reads

Primary cardiac angiosarcoma with right atrial wall rupture: A case report.

Medicine (Baltimore) 2019 Apr;98(14):e15020

Department of Oncology and Hematology, Soonchunhyang University Seoul Hospital, Soonchunhyang University Seoul Hospital, Soonchunhyang University College of Medicine, Seoul, Republic of Korea.

Rationale: Cardiac angiosarcoma is the most common malignant tumor of the heart and a rare disease with rapid disease progression and poor prognosis. Cardiac wall rupture is an extremely rare complication.

Patient Concerns: A 32-year-old woman presented with an acute onset of epigastric pain and chest discomfort at first time when she visited an emergency room. Read More

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http://dx.doi.org/10.1097/MD.0000000000015020DOI Listing
April 2019
5 Reads

Spotlight on aldoxorubicin (INNO-206) and its potential in the treatment of soft tissue sarcomas: evidence to date.

Authors:
Lee D Cranmer

Onco Targets Ther 2019 18;12:2047-2062. Epub 2019 Mar 18.

Division of Medical Oncology, University of Washington, Seattle, WA, USA,

Anthracyclines, and doxorubicin in particular, remain a mainstay of sarcoma therapy. Despite modest activity and significant toxicities, no cytotoxic monotherapy has yet yielded superior overall survival over doxorubicin for therapy of advanced soft tissue sarcomas in a randomized trial. Similarly, combination regimens have also been unable to overcome doxorubicin in terms of overall survival. Read More

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https://www.dovepress.com/spotlight-on-aldoxorubicin-inno-20
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http://dx.doi.org/10.2147/OTT.S145539DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6430065PMC
March 2019
10 Reads

Use of whole exome sequencing in the NICU: Case of an extremely low birth weight infant with syndromic features.

Mol Cell Probes 2019 Mar 15. Epub 2019 Mar 15.

University of Cologne, Medical Faculty and University Hospital, Department of Pediatrics, Division of Pediatric Neurology, Germany; University of Cologne, Medical Faculty, Center for Molecular Medicine Cologne (CMMC), Germany. Electronic address:

Single gene (Mendelian) disorders are one of the leading causes of neonatal morbidity and mortality. However, in the setting of preterm birth phenotypic features of genetic diseases are often undifferentiated and are clinically very difficult to interpret based on the wide range of differential diagnoses. We report an extremely low birth weight infant (ELBW) born prematurely at 23 + 0 gestational weeks after twin pregnancy with a novel clinical manifestation with persistent hyperglycaemia as well as the known manifestations of disease-associated hypokinesia, renal salt wasting, and multifocal atrial tachycardia. Read More

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http://dx.doi.org/10.1016/j.mcp.2019.03.002DOI Listing
March 2019
2 Reads

Establishment of cell line and in vivo mouse model of canine Langerhans cell histiocytosis.

Vet Comp Oncol 2019 Mar 18. Epub 2019 Mar 18.

Laboratory of Veterinary Pathology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Japan.

A cell line named FB-LCH01, derived from a dog diagnosed with Langerhans cell histiocytosis, was established and characterized. FB-LCH01 had C-shaped nucleoli, characterized by modal chromosome aberrations. The original tumor cells as well as established FB-LCH01 cells were immunopositive for HLA-DR, Iba-1 and E-cadherin, and immunonegative for CD163 and CD204, suggesting Langerhans cell origin. Read More

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http://dx.doi.org/10.1111/vco.12476DOI Listing
March 2019
1 Read

Lightning striking twice: Redo mitral valve replacement due to recurrent cardiac sarcoma using partial autotransplantation technique.

J Thorac Cardiovasc Surg 2019 Feb 11. Epub 2019 Feb 11.

Department of Cardiology, Houston Methodist DeBakey Heart and Vascular Center, Houston, Tex.

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http://dx.doi.org/10.1016/j.jtcvs.2019.01.096DOI Listing
February 2019

[Primary histiocytic sarcoma of the aortic valve as a trigger of heart failure in a crossbreed dog].

Schweiz Arch Tierheilkd 2019 Mar;161(3):165-169

Institut für Tierpathologie, Departement für Infektionskrankheiten und Pathobiologie, Vetsuisse-Fakultät Universität Bern.

Introduction: A case of a histiocytic sarcoma at the aortic valve with multiple metastases in the ventricular myocardium, ventricular endocardium and mitral valves in a male crossbreed dog is described. Neoplasia resulted in intermittent forward heart failure, thrombosis, myocardial infarction, and ventricular tachycardia. Read More

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http://dx.doi.org/10.17236/sat00199DOI Listing
March 2019
2 Reads

Role of Multimodal Cardiac Imaging in Diagnosing a Primary Intimal Sarcoma of the Left Atrial Appendage.

Tex Heart Inst J 2019 02 1;46(1):28-31. Epub 2019 Feb 1.

Primary cardiac tumors are rare, and most are benign. Intimal sarcomas are among the rarest of the malignant cardiac tumors; they are aggressive and associated with a poor prognosis. Whereas transesophageal echocardiography has been instrumental in evaluating cardiac masses, other imaging methods, such as cardiac magnetic resonance, have proved invaluable in accurately characterizing these masses. Read More

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http://dx.doi.org/10.14503/THIJ-16-5896DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6379013PMC
February 2019
1 Read

Short-Term Changes in Cardiac Function in Osteosarcoma Patients Receiving Anthracyclines.

J Adolesc Young Adult Oncol 2019 Feb 22. Epub 2019 Feb 22.

2 Department of Cardiology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas.

Studies of cardiac function in adolescent and young adult survivors have been performed at least a decade after anthracycline exposure, with little knowledge of short-term changes in cardiac function in this age group. To this end, we evaluated cardiac function within a 2-year period among 18 patients who received high-dose anthracyclines for osteosarcoma treatment. At 2 years, there was a significant decline in left ventricular ejection fraction (p = 0. Read More

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http://dx.doi.org/10.1089/jayao.2018.0141DOI Listing
February 2019
1 Read

Multiple hepatic metastases of cardiac angiosarcoma.

Autops Case Rep 2018 Oct-Dec;8(4):e2018048. Epub 2018 Oct 9.

University of Campinas (Unicamp), School of Medical Sciences, Department of Gastroenterology (Gastrocentro). Campinas, SP, Brazil.

The differential diagnosis of hepatic focal lesions is challenging because the etiology can be inflammatory, infectious, and even neoplastic. A rare cause of metastatic liver nodules is cardiac angiosarcoma. We report a case of this tumor, which was diagnosed only after autopsy. Read More

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http://dx.doi.org/10.4322/acr.2018.048DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360823PMC
October 2018
1 Read

Imaging, Surgical, and Pathology Findings of a Myxoid Aortic Sarcoma: When Distal Embolization Uncovers a Bigger Problem.

Aorta (Stamford) 2018 Apr 15;6(2):65-67. Epub 2019 Feb 15.

Division Cardiac Surgery, Indiana University, Indianapolis, Indiana.

Aortic sarcomas are a very rare condition typically characterized by a deceiving presentation. Making a correct diagnosis is based on the application of an algorithm which allows to identify the primary disease site and to obtain a tissue diagnosis. Surgical aortic resection with adjuvant therapy offers the best palliation, particularly in cases of well-differentiated tumors with no evidence of diffuse metastatic spread. Read More

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http://dx.doi.org/10.1055/s-0039-1678548DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6377361PMC
April 2018
1 Read

Primary cardiac synovial sarcoma that was continuous with the mitral valve caused severe thrombocytopenia: a case report.

J Cardiothorac Surg 2019 Feb 4;14(1):30. Epub 2019 Feb 4.

Cardiac Surgery Department, Peking University People's Hospital, Beijing, 100044, China.

Background: Primary cardiac sarcomas are exceedingly rare, and they commonly result in nonspecific constitutional symptoms such as shortness of breath, weight loss, and anaemia-related fatigue and malaise. However, thrombocytopenia has very rarely been reported in association with cardiac tumours, either benign or malignant. We report one case of primary cardiac synovial sarcoma continuous with the mitral valve, which was accompanied by severe thrombocytopenia, and the platelet counts returned rapidly to a normal range early after tumour excision and without any special therapies. Read More

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http://dx.doi.org/10.1186/s13019-019-0852-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360734PMC
February 2019
17 Reads

Undifferentiated sarcoma of the pericardium after radiation therapy for Hodgkin's lymphoma.

Ter Arkh 2018 Aug;90(8):69-73

N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia, Moscow, Russia.

Primary sarcomas of the pericardium are extremely rare malignant tumors of the heart. The incidence of sarcoma increases after radiation therapy in the field of breast. The specific features of this case report are the difficulties in diagnostics of undifferentiated spindle-cell sarcoma of the pericardium and the connection between the disease and the radiation therapy for Hodgkin's lymphoma. Read More

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http://dx.doi.org/10.26442/terarkh201890869-73DOI Listing
August 2018
1 Read

Near Total Occlusion of Right Ventricle by Cardiac Mass.

J Cardiothorac Vasc Anesth 2018 Dec 25. Epub 2018 Dec 25.

Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University, Baltimore, MD.

The incidence of primary cardiac tumors is very rare (0.02%) with the majority being benign. Angiosarcoma is the most common malignant cardiac tumor. Read More

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http://dx.doi.org/10.1053/j.jvca.2018.12.018DOI Listing
December 2018
4 Reads

Unusual endobronchial prostatic metastatic tumor occluding right main bronchus.

Asian Cardiovasc Thorac Ann 2019 Mar 23;27(3):228-230. Epub 2019 Jan 23.

2 Department of Thoracic Surgery, Liverpool Heart & Chest Hospital, Liverpool, UK.

Endobronchial metastasis from extrapulmonary solid tumors is rare, and endobronchial metastasis from the prostate is even more unusual. An 80-year-old patient presented with significant dyspnea secondary to metastatic stromal cell sarcoma of the prostate, which occluded the right main bronchus. The tumor, causing complete collapse of the right lung, was found on computed tomography and confirmed by bronchoscopy. Read More

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http://dx.doi.org/10.1177/0218492319827668DOI Listing
March 2019
6 Reads

Heart failure due to cardiac myeloid sarcoma.

Eur Heart J Cardiovasc Imaging 2019 Jan 10. Epub 2019 Jan 10.

University Clinic of Internal Medicine III, Cardiology and Angiology, Medical University of Innsbruck, Anichstrasse 35, Innsbruck, Austria.

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http://dx.doi.org/10.1093/ehjci/jey226DOI Listing
January 2019
5 Reads

Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines.

Authors:
Clotilde Théry Kenneth W Witwer Elena Aikawa Maria Jose Alcaraz Johnathon D Anderson Ramaroson Andriantsitohaina Anna Antoniou Tanina Arab Fabienne Archer Georgia K Atkin-Smith D Craig Ayre Jean-Marie Bach Daniel Bachurski Hossein Baharvand Leonora Balaj Shawn Baldacchino Natalie N Bauer Amy A Baxter Mary Bebawy Carla Beckham Apolonija Bedina Zavec Abderrahim Benmoussa Anna C Berardi Paolo Bergese Ewa Bielska Cherie Blenkiron Sylwia Bobis-Wozowicz Eric Boilard Wilfrid Boireau Antonella Bongiovanni Francesc E Borràs Steffi Bosch Chantal M Boulanger Xandra Breakefield Andrew M Breglio Meadhbh Á Brennan David R Brigstock Alain Brisson Marike Ld Broekman Jacqueline F Bromberg Paulina Bryl-Górecka Shilpa Buch Amy H Buck Dylan Burger Sara Busatto Dominik Buschmann Benedetta Bussolati Edit I Buzás James Bryan Byrd Giovanni Camussi David Rf Carter Sarah Caruso Lawrence W Chamley Yu-Ting Chang Chihchen Chen Shuai Chen Lesley Cheng Andrew R Chin Aled Clayton Stefano P Clerici Alex Cocks Emanuele Cocucci Robert J Coffey Anabela Cordeiro-da-Silva Yvonne Couch Frank Aw Coumans Beth Coyle Rossella Crescitelli Miria Ferreira Criado Crislyn D'Souza-Schorey Saumya Das Amrita Datta Chaudhuri Paola de Candia Eliezer F De Santana Olivier De Wever Hernando A Del Portillo Tanguy Demaret Sarah Deville Andrew Devitt Bert Dhondt Dolores Di Vizio Lothar C Dieterich Vincenza Dolo Ana Paula Dominguez Rubio Massimo Dominici Mauricio R Dourado Tom Ap Driedonks Filipe V Duarte Heather M Duncan Ramon M Eichenberger Karin Ekström Samir El Andaloussi Celine Elie-Caille Uta Erdbrügger Juan M Falcón-Pérez Farah Fatima Jason E Fish Miguel Flores-Bellver András Försönits Annie Frelet-Barrand Fabia Fricke Gregor Fuhrmann Susanne Gabrielsson Ana Gámez-Valero Chris Gardiner Kathrin Gärtner Raphael Gaudin Yong Song Gho Bernd Giebel Caroline Gilbert Mario Gimona Ilaria Giusti Deborah Ci Goberdhan André Görgens Sharon M Gorski David W Greening Julia Christina Gross Alice Gualerzi Gopal N Gupta Dakota Gustafson Aase Handberg Reka A Haraszti Paul Harrison Hargita Hegyesi An Hendrix Andrew F Hill Fred H Hochberg Karl F Hoffmann Beth Holder Harry Holthofer Baharak Hosseinkhani Guoku Hu Yiyao Huang Veronica Huber Stuart Hunt Ahmed Gamal-Eldin Ibrahim Tsuneya Ikezu Jameel M Inal Mustafa Isin Alena Ivanova Hannah K Jackson Soren Jacobsen Steven M Jay Muthuvel Jayachandran Guido Jenster Lanzhou Jiang Suzanne M Johnson Jennifer C Jones Ambrose Jong Tijana Jovanovic-Talisman Stephanie Jung Raghu Kalluri Shin-Ichi Kano Sukhbir Kaur Yumi Kawamura Evan T Keller Delaram Khamari Elena Khomyakova Anastasia Khvorova Peter Kierulf Kwang Pyo Kim Thomas Kislinger Mikael Klingeborn David J Klinke Miroslaw Kornek Maja M Kosanović Árpád Ferenc Kovács Eva-Maria Krämer-Albers Susanne Krasemann Mirja Krause Igor V Kurochkin Gina D Kusuma Sören Kuypers Saara Laitinen Scott M Langevin Lucia R Languino Joanne Lannigan Cecilia Lässer Louise C Laurent Gregory Lavieu Elisa Lázaro-Ibáñez Soazig Le Lay Myung-Shin Lee Yi Xin Fiona Lee Debora S Lemos Metka Lenassi Aleksandra Leszczynska Isaac Ts Li Ke Liao Sten F Libregts Erzsebet Ligeti Rebecca Lim Sai Kiang Lim Aija Linē Karen Linnemannstöns Alicia Llorente Catherine A Lombard Magdalena J Lorenowicz Ákos M Lörincz Jan Lötvall Jason Lovett Michelle C Lowry Xavier Loyer Quan Lu Barbara Lukomska Taral R Lunavat Sybren Ln Maas Harmeet Malhi Antonio Marcilla Jacopo Mariani Javier Mariscal Elena S Martens-Uzunova Lorena Martin-Jaular M Carmen Martinez Vilma Regina Martins Mathilde Mathieu Suresh Mathivanan Marco Maugeri Lynda K McGinnis Mark J McVey David G Meckes Katie L Meehan Inge Mertens Valentina R Minciacchi Andreas Möller Malene Møller Jørgensen Aizea Morales-Kastresana Jess Morhayim François Mullier Maurizio Muraca Luca Musante Veronika Mussack Dillon C Muth Kathryn H Myburgh Tanbir Najrana Muhammad Nawaz Irina Nazarenko Peter Nejsum Christian Neri Tommaso Neri Rienk Nieuwland Leonardo Nimrichter John P Nolan Esther Nm Nolte-'t Hoen Nicole Noren Hooten Lorraine O'Driscoll Tina O'Grady Ana O'Loghlen Takahiro Ochiya Martin Olivier Alberto Ortiz Luis A Ortiz Xabier Osteikoetxea Ole Østergaard Matias Ostrowski Jaesung Park D Michiel Pegtel Hector Peinado Francesca Perut Michael W Pfaffl Donald G Phinney Bartijn Ch Pieters Ryan C Pink David S Pisetsky Elke Pogge von Strandmann Iva Polakovicova Ivan Kh Poon Bonita H Powell Ilaria Prada Lynn Pulliam Peter Quesenberry Annalisa Radeghieri Robert L Raffai Stefania Raimondo Janusz Rak Marcel I Ramirez Graça Raposo Morsi S Rayyan Neta Regev-Rudzki Franz L Ricklefs Paul D Robbins David D Roberts Silvia C Rodrigues Eva Rohde Sophie Rome Kasper Ma Rouschop Aurelia Rughetti Ashley E Russell Paula Saá Susmita Sahoo Edison Salas-Huenuleo Catherine Sánchez Julie A Saugstad Meike J Saul Raymond M Schiffelers Raphael Schneider Tine Hiorth Schøyen Aaron Scott Eriomina Shahaj Shivani Sharma Olga Shatnyeva Faezeh Shekari Ganesh Vilas Shelke Ashok K Shetty Kiyotaka Shiba Pia R-M Siljander Andreia M Silva Agata Skowronek Orman L Snyder Rodrigo Pedro Soares Barbara W Sódar Carolina Soekmadji Javier Sotillo Philip D Stahl Willem Stoorvogel Shannon L Stott Erwin F Strasser Simon Swift Hidetoshi Tahara Muneesh Tewari Kate Timms Swasti Tiwari Rochelle Tixeira Mercedes Tkach Wei Seong Toh Richard Tomasini Ana Claudia Torrecilhas Juan Pablo Tosar Vasilis Toxavidis Lorena Urbanelli Pieter Vader Bas Wm van Balkom Susanne G van der Grein Jan Van Deun Martijn Jc van Herwijnen Kendall Van Keuren-Jensen Guillaume van Niel Martin E van Royen Andre J van Wijnen M Helena Vasconcelos Ivan J Vechetti Tiago D Veit Laura J Vella Émilie Velot Frederik J Verweij Beate Vestad Jose L Viñas Tamás Visnovitz Krisztina V Vukman Jessica Wahlgren Dionysios C Watson Marca Hm Wauben Alissa Weaver Jason P Webber Viktoria Weber Ann M Wehman Daniel J Weiss Joshua A Welsh Sebastian Wendt Asa M Wheelock Zoltán Wiener Leonie Witte Joy Wolfram Angeliki Xagorari Patricia Xander Jing Xu Xiaomei Yan María Yáñez-Mó Hang Yin Yuana Yuana Valentina Zappulli Jana Zarubova Vytautas Žėkas Jian-Ye Zhang Zezhou Zhao Lei Zheng Alexander R Zheutlin Antje M Zickler Pascale Zimmermann Angela M Zivkovic Davide Zocco Ewa K Zuba-Surma

J Extracell Vesicles 2018 23;7(1):1535750. Epub 2018 Nov 23.

Jagiellonian University, Faculty of Biochemistry, Biophysics and Biotechnology, Department of Cell Biology, Kraków, Poland.

The last decade has seen a sharp increase in the number of scientific publications describing physiological and pathological functions of extracellular vesicles (EVs), a collective term covering various subtypes of cell-released, membranous structures, called exosomes, microvesicles, microparticles, ectosomes, oncosomes, apoptotic bodies, and many other names. However, specific issues arise when working with these entities, whose size and amount often make them difficult to obtain as relatively pure preparations, and to characterize properly. The International Society for Extracellular Vesicles (ISEV) proposed Minimal Information for Studies of Extracellular Vesicles ("MISEV") guidelines for the field in 2014. Read More

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https://www.tandfonline.com/doi/full/10.1080/20013078.2018.1
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http://dx.doi.org/10.1080/20013078.2018.1535750DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322352PMC
November 2018
54 Reads

Computed tomography imaging characteristics of primary atrial intimal sarcoma.

Clin Imaging 2019 Mar - Apr;54:112-115. Epub 2018 Dec 10.

Newark Beth Israel Medical Center, Radiology Department, USA. Electronic address:

We present a 36-year-old man who presented to our emergency department with acute onset shortness of breath and syncope. He was found to have a large left atrial mass on initial computed tomography (CT) which was confirmed by echocardiography. Tumor biopsy and attempted excision were performed, showing a primary cardiac spindle cell sarcoma that was unable to be resected, to which the patient eventually succumbed to. Read More

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http://dx.doi.org/10.1016/j.clinimag.2018.12.004DOI Listing
December 2018
3 Reads

Erratum to cardiac arrest due to coronary embolism from a metastatic sarcoma recovered through aspiration thrombectomy.

J Thorac Dis 2018 Nov;10(11):E791

Division of Cardiology, Department of Internal Medicine, College of Medicine, Gyeongsang National University, Gyeongsang National University Hospital, Jinju, Korea.

[This corrects the article DOI: 10.21037/jtd.2018. Read More

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http://jtd.amegroups.com/article/view/25162/19123
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http://dx.doi.org/10.21037/jtd.2018.10.77DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6297413PMC
November 2018
10 Reads

Stereotactic Body Radiation Therapy for the Treatment of Primary Cardiac Angiosarcoma Causing Hemodynamic Instability.

Pract Radiat Oncol 2019 01;9(1):5-8

Department of Radiation Oncology, Washington University School of Medicine in Saint Louis, Saint Louis, Missouri. Electronic address:

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http://dx.doi.org/10.1016/j.prro.2018.07.004DOI Listing
January 2019
4 Reads

Paraneoplatic Obstruction of Descending Thoracic Aorta: A New Indication for Endovascular Surgery?

Ann Thorac Surg 2019 Jan 2. Epub 2019 Jan 2.

Department of Cardiac Surgery, School of Medicine, University "Federico II", Naples Italy.

We describe the rare case of a 61 years-old man, admitted in emergency to our department with visceral-organ and lower-limb malperfusion because an unknown retroperitoneal high grade undifferentiated pleomorphic sarcoma and a severe paraneoplastic obstruction of the descending thoracic aorta, treated with TEVAR The postoperative period was uneventful and patient was discharged within four days. At six- month follow-up CT scan showed complete patency of the descending thoracic aorta. This single case experience shows that TEVAR can be a less invasive and effective off-label alternative to exclude infiltrated and/or obstructed descending thoracic aorta avoiding conventional surgery. Read More

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http://dx.doi.org/10.1016/j.athoracsur.2018.12.004DOI Listing
January 2019
3 Reads

A Breath-Taking Diagnosis.

N Engl J Med 2019 01;380(1):81-87

From the Department of Medicine, Brigham and Women's Hospital, Boston.

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http://dx.doi.org/10.1056/NEJMcps1807721DOI Listing
January 2019
11 Reads

Case 1: Syncope in a 16-year-old Girl.

Pediatr Rev 2019 Jan;40(1):37-39

Department of Pediatrics, Division of Pediatric Emergency Medicine, St Louis Children's Hospital/Washington University in St Louis, St Louis, MO.

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http://dx.doi.org/10.1542/pir.2018-0028DOI Listing
January 2019
4 Reads

Retrospective analysis of 11 cases of primary cardiac valve tumors.

Anatol J Cardiol 2019 Jan;21(1):11-17

Department of Cardiovascular Surgery, The Second Affiliated Hospital (Xinqiao Hospital) of Chinese People's Liberation Army Medical University; Chongqing-China.

Objective: To explore the clinical features and surgical treatment experience of primary cardiac valve tumor.

Methods: The present study retrospectively analyzed the clinical data of 11 patients with primary valvular tumors who underwent surgical treatment in our department from 1980 to 2016. Echocardiography of preoperative patients was indicated as a heart valve tumor. Read More

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http://dx.doi.org/10.14744/AnatolJCardiol.2018.40325DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6382897PMC
January 2019
5 Reads

Evaluation of a cardiac sarcoma with CT multislice contrast-enhanced and 18FDG-PET/TC.

Radiol Case Rep 2019 Mar 17;14(3):368-371. Epub 2018 Dec 17.

Department of Biomedicine and Prevention, UOC of Diagnostic Imaging, University of Rome "Tor Vergata", Viale Oxford 81, Rome 00133, Italy.

We present the case of an adult male who arrived to our emergency room with progressive dyspnea that had been ongoing for 2 months. During the radiological investigation, we found a large intracardiac mass, which invaded the pericardium, pulmonary trunk, pulmonary arteries, and left ventricle. Studies done with the 18FDG-PET/CT scan helped us to determine the malignant nature of the mass and to suspect the diagnosis of rhabdomyosarcoma. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S19300433183051
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http://dx.doi.org/10.1016/j.radcr.2018.12.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299141PMC
March 2019
15 Reads

Primary cardiac sarcomas: A multi-national retrospective review.

Cancer Med 2019 Jan 21;8(1):104-110. Epub 2018 Dec 21.

Sarcoma Department, Mount Sinai Hospital, Toronto, Ontario, Canada.

Background: Primary cardiac sarcoma (PCS) is a rare but often fatal disease. The current study aimed to analyze the impact of baseline demographics, local and systemic therapies in a contemporary cohort.

Methods: Clinical records of PCS across six institutions in three continents were reviewed. Read More

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http://dx.doi.org/10.1002/cam4.1897DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346258PMC
January 2019
4 Reads

A Case of Undifferentiated Sarcoma in the Superior Vena Cava and Bilateral Cervical Veins.

Am J Case Rep 2018 Dec 19;19:1507-1514. Epub 2018 Dec 19.

Department of Pathology, Tachikawa General Hospital, Nagaoka, Niigata, Japan.

BACKGROUND Intimal sarcoma (IS) is a malignant mesenchymal tumor with predominantly intraluminal growth in large vessels and the heart. Due to the rarity of cases it often poses diagnostic problems in clinical and pathological settings. Although the classification of IS is still controversial, undifferentiated type of IS has recently been found to show immunohistochemical positivity with MDM2, CDK4, or PDGFRA and amplification of MDM2/CDK4 and PDGFRA. Read More

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https://www.amjcaserep.com/abstract/index/idArt/911659
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http://dx.doi.org/10.12659/AJCR.911659DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320552PMC
December 2018
13 Reads

aPKC controls endothelial growth by modulating c-Myc via FoxO1 DNA-binding ability.

Nat Commun 2018 12 17;9(1):5357. Epub 2018 Dec 17.

Laboratory for Cell Polarity and Organogenesis, Max Planck Institute for Heart and Lung Research, 61231, Bad Nauheim, Germany.

Strict regulation of proliferation is vital for development, whereas unregulated cell proliferation is a fundamental characteristic of cancer. The polarity protein atypical protein kinase C lambda/iota (aPKCλ) is associated with cell proliferation through unknown mechanisms. In endothelial cells, suppression of aPKCλ impairs proliferation despite hyperactivated mitogenic signaling. Read More

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http://www.nature.com/articles/s41467-018-07739-0
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http://dx.doi.org/10.1038/s41467-018-07739-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6297234PMC
December 2018
17 Reads

A rare case of intracardiac fibrosarcoma with myxoid features inducing venous occlusion in a dog - a case report.

BMC Vet Res 2018 Dec 14;14(1):398. Epub 2018 Dec 14.

Department of Pathology, University of Agricultural Sciences and Veterinary Medicine "Ion Ionescu de la Brad", Iași, Romania.

Background: In both humans and animals, cardiac fibrosarcoma is rare among primary cardiac malignant neoplasia. The overall prevalence of cardiac neoplasia in dogs is low, reported to be between 0.17% and 0. Read More

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http://dx.doi.org/10.1186/s12917-018-1735-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6295096PMC
December 2018
5 Reads

Cardiotoxicity with trabectedin in the treatment of advanced soft tissue sarcoma.

Anticancer Drugs 2019 Jan;30(1):110-115

Department of Oncology, Cambridge University Hospitals NHS Foundation Trust, Addenbrooke's Hospital, Cambridge Biomedical Campus, Cambridge, UK.

Trabectedin is used routinely in the palliative management of patients with advanced soft tissue sarcoma. It is not generally considered to be cardiotoxic, and there is no specific caution for its use in patients with a history of cardiac disease or risk factors. Here, we report six cases from a single academic centre where life-threatening cardiotoxicity occurred acutely during treatment with trabectedin. Read More

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http://dx.doi.org/10.1097/CAD.0000000000000693DOI Listing
January 2019
4 Reads
1.891 Impact Factor

Angiosarcoma of the right atrium with extension to the superior and inferior vena cavae.

J Card Surg 2018 Dec 11;33(12):806-807. Epub 2018 Dec 11.

Department of Cardiac Surgery, Kerckhoff-Heart Center Bad Nauheim, Bad Nauheim, Germany.

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http://dx.doi.org/10.1111/jocs.13964DOI Listing
December 2018
5 Reads

Imaging and Surgical Treatment of Primary Pulmonary Artery Sarcoma.

Int J Cardiovasc Imaging 2018 Dec 8. Epub 2018 Dec 8.

Houston Methodist DeBakey Heart and Vascular Center, Houston, TX, USA.

Primary pulmonary artery sarcoma is a rare tumor originating from the pulmonary artery tree. Given the low incidence, few centers have reported on more than a handful of cases. Because of its rarity it is also commonly misdiagnosed as pulmonary embolism. Read More

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http://dx.doi.org/10.1007/s10554-018-1489-8DOI Listing
December 2018
2 Reads

Retrospective analysis of 11 cases of primary cardiac valve tumors.

Anatol J Cardiol 2018 Dec 6. Epub 2018 Dec 6.

Department of Ultrasound Diagnosis, The Second Affiliated Hospital (Xinqiao Hospital) of Chinese People's Liberation Army Medical University; Chongqing-China.

Objective: To explore the clinical features and surgical treatment experience of primary cardiac valve tumor.

Methods: The present study retrospectively analyzed the clinical data of 11 patients with primary valvular tumors who underwent surgical treatment in our department from 1980 to 2016. Echocardiography of preoperative patients was indicated as a heart valve tumor. Read More

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http://dx.doi.org/10.14744/AnatolJCardiol.2018.40325DOI Listing
December 2018
3 Reads

Primary Cardiac Angiosarcoma with Rare Presenting Feature and Successful Surgical Treatment.

Braz J Cardiovasc Surg 2018 Sep-Oct;33(5):525-527

Department of Cardiovascular Surgery, Kartal Kosuyolu Heart Research and Training Hospital, Istanbul, Turkey.

Primary angiosarcoma is a rare clinical entity, it's typically located within the right atrium and known to be rapidly fatal. A 37-year-old female was presented with a history of recurrent facial paralysis and left hemiparesis. A cranial mass was identified at cranial magnetic resonance imaging and she underwent neurosurgery operation. Read More

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http://www.bjcvs.org/pdfRBCCV/v33n5a16.pdf
Publisher Site
http://dx.doi.org/10.21470/1678-9741-2017-0239DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6257526PMC
March 2019
13 Reads

Predictors of Discharge Disposition Following Laminectomy for Intradural Extramedullary Spinal Tumors.

World Neurosurg 2019 Mar 27;123:e427-e432. Epub 2018 Nov 27.

Department of Orthopaedic Surgery, Icahn School of Medicine at Mount Sinai, New York, New York, USA. Electronic address:

Objective: To identify independent risk factors for non-home discharge in patients undergoing laminectomy for intradural extramedullary spinal tumors.

Methods: We performed a retrospective cohort analysis of data from the American College of Surgeons National Surgical Quality Improvement Program from 2011 to 2014. Adult patients who underwent laminectomy for the excision of intradural extramedullary spinal tumors were included and divided into 2 groups based on home or non-home discharge disposition. Read More

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http://dx.doi.org/10.1016/j.wneu.2018.11.183DOI Listing
March 2019
14 Reads

Perturbations in Traffic: Aberrant Nucleocytoplasmic Transport at the Heart of Neurodegeneration.

Cells 2018 Nov 26;7(12). Epub 2018 Nov 26.

Azrieli Faculty of Medicine, Bar-Ilan University, Safed 1311502, Israel.

Neurodegenerative diseases, such as amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), and Huntington's disease (HD), are characterized by intracellular aggregation of proteins. In the case of ALS and FTD, these protein aggregates are found in the cytoplasm of affected neurons and contain certain RNA-binding proteins (RBPs), namely the TAR DNA-binding protein of 43 kDa (TDP-43) and the fused in sarcoma (FUS) gene product. TDP-43 and FUS are nuclear proteins and their displacement to the cytoplasm is thought to be adverse in at least two ways: loss-of-function in the nucleus and gain-of-toxicity in the cytoplasm. Read More

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http://www.mdpi.com/2073-4409/7/12/232
Publisher Site
http://dx.doi.org/10.3390/cells7120232DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6316434PMC
November 2018
21 Reads

A 20-Year Experience With Resection of Primary Cardiac Tumors and Metastatic Tumors of the Heart.

Ann Thorac Surg 2019 Apr 22;107(4):1126-1131. Epub 2018 Nov 22.

Department of Cardiothoracic Surgery, Weill Cornell Medicine, New York, New York.

Background: Cardiac tumors are uncommon, occurring in less than 1% of the population, and are comprised of numerous tumor types. Management of certain tumors types such as sarcoma have evolved and improved in the recent era. We evaluate the outcomes of patients who underwent resection of benign or malignant cardiac tumors with a focused review of cardiac sarcomas. Read More

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http://dx.doi.org/10.1016/j.athoracsur.2018.10.023DOI Listing
April 2019
15 Reads

Synovial sarcoma of the aortopulmonary window.

J Card Surg 2018 Dec 22;33(12):797-798. Epub 2018 Nov 22.

Cardiovascular Surgeon, Department of Cardiovascular Surgery, Virgen de las Nieves University Hospital, Granada, Spain.

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http://dx.doi.org/10.1111/jocs.13951DOI Listing
December 2018
2 Reads

Periplocin, the most anti-proliferative constituent of Periploca sepium, specifically kills liposarcoma cells by death receptor mediated apoptosis.

Phytomedicine 2018 Dec 11;51:162-170. Epub 2018 Oct 11.

Institute of Pharmaceutical Sciences, Department of Pharmacognosy, University of Graz, Universitaetsplatz 4/1, 8010 Graz, Austria.

Background: During a screening of Chinese plants traditionally used for the treatment of cancer and related diseases, extracts of the root bark of Periploca sepium Bunge showed strong cytotoxic activity.

Purpose: Isolate and identify cytotoxic compounds from P. sepium and investigate the effects and mechanism of action on different cancer cell lines. Read More

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http://dx.doi.org/10.1016/j.phymed.2018.10.008DOI Listing
December 2018
19 Reads

The impact of postoperative therapy on primary cardiac sarcoma.

J Thorac Cardiovasc Surg 2018 Dec 6;156(6):2194-2203. Epub 2018 Jun 6.

Department of Medicine (Oncology), Stanford University School of Medicine, Stanford, Calif. Electronic address:

Objective: Primary cardiac sarcomas (PCS) are extremely rare, portend a very poor prognosis, and have limited outcomes data to direct management. This study evaluated the impact of postoperative chemotherapy and/or radiotherapy on survival for PCS.

Methods: A retrospective chart review was conducted of 12 patients diagnosed with and who underwent resection for PCS at a single institution between 2000 and 2016. Read More

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http://dx.doi.org/10.1016/j.jtcvs.2018.04.127DOI Listing
December 2018
16 Reads

Doxorubicin-induced heart failure in cancer patients: A cohort study based on the Korean National Health Insurance Database.

Cancer Med 2018 Dec 19;7(12):6084-6092. Epub 2018 Nov 19.

Department of Cardiology, Center for Clinical Specialty, National Cancer Center, Goyang-si, Korea.

Background: Doxorubicin is a typical anticancer drug that causes cardiomyopathy and heart failure (HF). The aim of our study was to investigate incidence, risk factors for doxorubicin-induced HF in Korean cancer patients and their survival rate, utilizing a nationwide population-based cohort.

Methods: We analyzed 58 541 cancer patients who received doxorubicin between 2003 and 2010. Read More

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http://doi.wiley.com/10.1002/cam4.1886
Publisher Site
http://dx.doi.org/10.1002/cam4.1886DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6308087PMC
December 2018
33 Reads

Frequency of Transition From Stage A to Stage B Heart Failure After Initiating Potentially Cardiotoxic Chemotherapy.

JACC Heart Fail 2018 Dec 7;6(12):1023-1032. Epub 2018 Nov 7.

Department of Internal Medicine, Section of Cardiovascular Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina; Department of Radiological Sciences, Wake Forest University School of Medicine, Winston-Salem, North Carolina; Department of Internal Medicine, Cardiology Division, Virginia Commonwealth University Health Sciences, Richmond, Virginia. Electronic address:

Objectives: This study sought to determine the prevalence of American Heart Association/American College of Cardiology Foundation (AHA/ACCF) heart failure (HF) stages after potentially cardiotoxic chemotherapy was initiated.

Background: For individuals receiving potentially cardiotoxic chemotherapy, the frequency of transitioning from Stage A to more advanced HF stages is not well described.

Methods: In 143 Stage A HF patients with breast cancer, lymphoma and leukemia, renal cell carcinoma, or sarcoma prior to and then at 3, 6, and 12 to 24 months after potentially cardiotoxic chemotherapy was initiated, we obtained blinded cardiac magnetic resonance measurements of left ventricular ejection fraction (LVEF). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22131779183064
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http://dx.doi.org/10.1016/j.jchf.2018.08.005DOI Listing
December 2018
13 Reads