4,849 results match your criteria Cardiac Sarcoma


Short-Term Changes in Cardiac Function in Osteosarcoma Patients Receiving Anthracyclines.

J Adolesc Young Adult Oncol 2019 Feb 22. Epub 2019 Feb 22.

2 Department of Cardiology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas.

Studies of cardiac function in adolescent and young adult survivors have been performed at least a decade after anthracycline exposure, with little knowledge of short-term changes in cardiac function in this age group. To this end, we evaluated cardiac function within a 2-year period among 18 patients who received high-dose anthracyclines for osteosarcoma treatment. At 2 years, there was a significant decline in left ventricular ejection fraction (p = 0. Read More

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http://dx.doi.org/10.1089/jayao.2018.0141DOI Listing
February 2019

Multiple hepatic metastases of cardiac angiosarcoma.

Autops Case Rep 2018 Oct-Dec;8(4):e2018048. Epub 2018 Oct 9.

University of Campinas (Unicamp), School of Medical Sciences, Department of Gastroenterology (Gastrocentro). Campinas, SP, Brazil.

The differential diagnosis of hepatic focal lesions is challenging because the etiology can be inflammatory, infectious, and even neoplastic. A rare cause of metastatic liver nodules is cardiac angiosarcoma. We report a case of this tumor, which was diagnosed only after autopsy. Read More

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http://dx.doi.org/10.4322/acr.2018.048DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360823PMC
October 2018

Imaging, Surgical, and Pathology Findings of a Myxoid Aortic Sarcoma: When Distal Embolization Uncovers a Bigger Problem.

Aorta (Stamford) 2018 Apr 15;6(2):65-67. Epub 2019 Feb 15.

Division Cardiac Surgery, Indiana University, Indianapolis, Indiana.

Aortic sarcomas are a very rare condition typically characterized by a deceiving presentation. Making a correct diagnosis is based on the application of an algorithm which allows to identify the primary disease site and to obtain a tissue diagnosis. Surgical aortic resection with adjuvant therapy offers the best palliation, particularly in cases of well-differentiated tumors with no evidence of diffuse metastatic spread. Read More

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http://dx.doi.org/10.1055/s-0039-1678548DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6377361PMC
April 2018
1 Read

One-Step for Lobectomy and Two-Step for Pneumonectomy: Different Dances for Different Tunes.

Semin Thorac Cardiovasc Surg 2019 Feb 5. Epub 2019 Feb 5.

Department of Cardiovascular Surgery, Houston Methodist DeBakey Heart & Vascular Center, Houston Methodist Hospital, Houston, Texas. Electronic address:

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http://dx.doi.org/10.1053/j.semtcvs.2019.02.011DOI Listing
February 2019

Primary cardiac synovial sarcoma that was continuous with the mitral valve caused severe thrombocytopenia: a case report.

J Cardiothorac Surg 2019 Feb 4;14(1):30. Epub 2019 Feb 4.

Cardiac Surgery Department, Peking University People's Hospital, Beijing, 100044, China.

Background: Primary cardiac sarcomas are exceedingly rare, and they commonly result in nonspecific constitutional symptoms such as shortness of breath, weight loss, and anaemia-related fatigue and malaise. However, thrombocytopenia has very rarely been reported in association with cardiac tumours, either benign or malignant. We report one case of primary cardiac synovial sarcoma continuous with the mitral valve, which was accompanied by severe thrombocytopenia, and the platelet counts returned rapidly to a normal range early after tumour excision and without any special therapies. Read More

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http://dx.doi.org/10.1186/s13019-019-0852-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360734PMC
February 2019
7 Reads

Undifferentiated sarcoma of the pericardium after radiation therapy for Hodgkin's lymphoma.

Ter Arkh 2018 Aug;90(8):69-73

N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia, Moscow, Russia.

Primary sarcomas of the pericardium are extremely rare malignant tumors of the heart. The incidence of sarcoma increases after radiation therapy in the field of breast. The specific features of this case report are the difficulties in diagnostics of undifferentiated spindle-cell sarcoma of the pericardium and the connection between the disease and the radiation therapy for Hodgkin's lymphoma. Read More

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http://dx.doi.org/10.26442/terarkh201890869-73DOI Listing

Near Total Occlusion of Right Ventricle by Cardiac Mass.

J Cardiothorac Vasc Anesth 2018 Dec 25. Epub 2018 Dec 25.

Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University, Baltimore, MD.

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http://dx.doi.org/10.1053/j.jvca.2018.12.018DOI Listing
December 2018
3 Reads

Unusual endobronchial prostatic metastatic tumor occluding right main bronchus.

Asian Cardiovasc Thorac Ann 2019 Mar 23;27(3):228-230. Epub 2019 Jan 23.

2 Department of Thoracic Surgery, Liverpool Heart & Chest Hospital, Liverpool, UK.

Endobronchial metastasis from extrapulmonary solid tumors is rare, and endobronchial metastasis from the prostate is even more unusual. An 80-year-old patient presented with significant dyspnea secondary to metastatic stromal cell sarcoma of the prostate, which occluded the right main bronchus. The tumor, causing complete collapse of the right lung, was found on computed tomography and confirmed by bronchoscopy. Read More

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http://dx.doi.org/10.1177/0218492319827668DOI Listing
March 2019
5 Reads

Heart failure due to cardiac myeloid sarcoma.

Eur Heart J Cardiovasc Imaging 2019 Jan 10. Epub 2019 Jan 10.

University Clinic of Internal Medicine III, Cardiology and Angiology, Medical University of Innsbruck, Anichstrasse 35, Innsbruck, Austria.

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http://dx.doi.org/10.1093/ehjci/jey226DOI Listing
January 2019
4 Reads

Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines.

Authors:
Clotilde Théry Kenneth W Witwer Elena Aikawa Maria Jose Alcaraz Johnathon D Anderson Ramaroson Andriantsitohaina Anna Antoniou Tanina Arab Fabienne Archer Georgia K Atkin-Smith D Craig Ayre Jean-Marie Bach Daniel Bachurski Hossein Baharvand Leonora Balaj Shawn Baldacchino Natalie N Bauer Amy A Baxter Mary Bebawy Carla Beckham Apolonija Bedina Zavec Abderrahim Benmoussa Anna C Berardi Paolo Bergese Ewa Bielska Cherie Blenkiron Sylwia Bobis-Wozowicz Eric Boilard Wilfrid Boireau Antonella Bongiovanni Francesc E Borràs Steffi Bosch Chantal M Boulanger Xandra Breakefield Andrew M Breglio Meadhbh Á Brennan David R Brigstock Alain Brisson Marike Ld Broekman Jacqueline F Bromberg Paulina Bryl-Górecka Shilpa Buch Amy H Buck Dylan Burger Sara Busatto Dominik Buschmann Benedetta Bussolati Edit I Buzás James Bryan Byrd Giovanni Camussi David Rf Carter Sarah Caruso Lawrence W Chamley Yu-Ting Chang Chihchen Chen Shuai Chen Lesley Cheng Andrew R Chin Aled Clayton Stefano P Clerici Alex Cocks Emanuele Cocucci Robert J Coffey Anabela Cordeiro-da-Silva Yvonne Couch Frank Aw Coumans Beth Coyle Rossella Crescitelli Miria Ferreira Criado Crislyn D'Souza-Schorey Saumya Das Amrita Datta Chaudhuri Paola de Candia Eliezer F De Santana Olivier De Wever Hernando A Del Portillo Tanguy Demaret Sarah Deville Andrew Devitt Bert Dhondt Dolores Di Vizio Lothar C Dieterich Vincenza Dolo Ana Paula Dominguez Rubio Massimo Dominici Mauricio R Dourado Tom Ap Driedonks Filipe V Duarte Heather M Duncan Ramon M Eichenberger Karin Ekström Samir El Andaloussi Celine Elie-Caille Uta Erdbrügger Juan M Falcón-Pérez Farah Fatima Jason E Fish Miguel Flores-Bellver András Försönits Annie Frelet-Barrand Fabia Fricke Gregor Fuhrmann Susanne Gabrielsson Ana Gámez-Valero Chris Gardiner Kathrin Gärtner Raphael Gaudin Yong Song Gho Bernd Giebel Caroline Gilbert Mario Gimona Ilaria Giusti Deborah Ci Goberdhan André Görgens Sharon M Gorski David W Greening Julia Christina Gross Alice Gualerzi Gopal N Gupta Dakota Gustafson Aase Handberg Reka A Haraszti Paul Harrison Hargita Hegyesi An Hendrix Andrew F Hill Fred H Hochberg Karl F Hoffmann Beth Holder Harry Holthofer Baharak Hosseinkhani Guoku Hu Yiyao Huang Veronica Huber Stuart Hunt Ahmed Gamal-Eldin Ibrahim Tsuneya Ikezu Jameel M Inal Mustafa Isin Alena Ivanova Hannah K Jackson Soren Jacobsen Steven M Jay Muthuvel Jayachandran Guido Jenster Lanzhou Jiang Suzanne M Johnson Jennifer C Jones Ambrose Jong Tijana Jovanovic-Talisman Stephanie Jung Raghu Kalluri Shin-Ichi Kano Sukhbir Kaur Yumi Kawamura Evan T Keller Delaram Khamari Elena Khomyakova Anastasia Khvorova Peter Kierulf Kwang Pyo Kim Thomas Kislinger Mikael Klingeborn David J Klinke Miroslaw Kornek Maja M Kosanović Árpád Ferenc Kovács Eva-Maria Krämer-Albers Susanne Krasemann Mirja Krause Igor V Kurochkin Gina D Kusuma Sören Kuypers Saara Laitinen Scott M Langevin Lucia R Languino Joanne Lannigan Cecilia Lässer Louise C Laurent Gregory Lavieu Elisa Lázaro-Ibáñez Soazig Le Lay Myung-Shin Lee Yi Xin Fiona Lee Debora S Lemos Metka Lenassi Aleksandra Leszczynska Isaac Ts Li Ke Liao Sten F Libregts Erzsebet Ligeti Rebecca Lim Sai Kiang Lim Aija Linē Karen Linnemannstöns Alicia Llorente Catherine A Lombard Magdalena J Lorenowicz Ákos M Lörincz Jan Lötvall Jason Lovett Michelle C Lowry Xavier Loyer Quan Lu Barbara Lukomska Taral R Lunavat Sybren Ln Maas Harmeet Malhi Antonio Marcilla Jacopo Mariani Javier Mariscal Elena S Martens-Uzunova Lorena Martin-Jaular M Carmen Martinez Vilma Regina Martins Mathilde Mathieu Suresh Mathivanan Marco Maugeri Lynda K McGinnis Mark J McVey David G Meckes Katie L Meehan Inge Mertens Valentina R Minciacchi Andreas Möller Malene Møller Jørgensen Aizea Morales-Kastresana Jess Morhayim François Mullier Maurizio Muraca Luca Musante Veronika Mussack Dillon C Muth Kathryn H Myburgh Tanbir Najrana Muhammad Nawaz Irina Nazarenko Peter Nejsum Christian Neri Tommaso Neri Rienk Nieuwland Leonardo Nimrichter John P Nolan Esther Nm Nolte-'t Hoen Nicole Noren Hooten Lorraine O'Driscoll Tina O'Grady Ana O'Loghlen Takahiro Ochiya Martin Olivier Alberto Ortiz Luis A Ortiz Xabier Osteikoetxea Ole Østergaard Matias Ostrowski Jaesung Park D Michiel Pegtel Hector Peinado Francesca Perut Michael W Pfaffl Donald G Phinney Bartijn Ch Pieters Ryan C Pink David S Pisetsky Elke Pogge von Strandmann Iva Polakovicova Ivan Kh Poon Bonita H Powell Ilaria Prada Lynn Pulliam Peter Quesenberry Annalisa Radeghieri Robert L Raffai Stefania Raimondo Janusz Rak Marcel I Ramirez Graça Raposo Morsi S Rayyan Neta Regev-Rudzki Franz L Ricklefs Paul D Robbins David D Roberts Silvia C Rodrigues Eva Rohde Sophie Rome Kasper Ma Rouschop Aurelia Rughetti Ashley E Russell Paula Saá Susmita Sahoo Edison Salas-Huenuleo Catherine Sánchez Julie A Saugstad Meike J Saul Raymond M Schiffelers Raphael Schneider Tine Hiorth Schøyen Aaron Scott Eriomina Shahaj Shivani Sharma Olga Shatnyeva Faezeh Shekari Ganesh Vilas Shelke Ashok K Shetty Kiyotaka Shiba Pia R-M Siljander Andreia M Silva Agata Skowronek Orman L Snyder Rodrigo Pedro Soares Barbara W Sódar Carolina Soekmadji Javier Sotillo Philip D Stahl Willem Stoorvogel Shannon L Stott Erwin F Strasser Simon Swift Hidetoshi Tahara Muneesh Tewari Kate Timms Swasti Tiwari Rochelle Tixeira Mercedes Tkach Wei Seong Toh Richard Tomasini Ana Claudia Torrecilhas Juan Pablo Tosar Vasilis Toxavidis Lorena Urbanelli Pieter Vader Bas Wm van Balkom Susanne G van der Grein Jan Van Deun Martijn Jc van Herwijnen Kendall Van Keuren-Jensen Guillaume van Niel Martin E van Royen Andre J van Wijnen M Helena Vasconcelos Ivan J Vechetti Tiago D Veit Laura J Vella Émilie Velot Frederik J Verweij Beate Vestad Jose L Viñas Tamás Visnovitz Krisztina V Vukman Jessica Wahlgren Dionysios C Watson Marca Hm Wauben Alissa Weaver Jason P Webber Viktoria Weber Ann M Wehman Daniel J Weiss Joshua A Welsh Sebastian Wendt Asa M Wheelock Zoltán Wiener Leonie Witte Joy Wolfram Angeliki Xagorari Patricia Xander Jing Xu Xiaomei Yan María Yáñez-Mó Hang Yin Yuana Yuana Valentina Zappulli Jana Zarubova Vytautas Žėkas Jian-Ye Zhang Zezhou Zhao Lei Zheng Alexander R Zheutlin Antje M Zickler Pascale Zimmermann Angela M Zivkovic Davide Zocco Ewa K Zuba-Surma

J Extracell Vesicles 2018 23;7(1):1535750. Epub 2018 Nov 23.

Jagiellonian University, Faculty of Biochemistry, Biophysics and Biotechnology, Department of Cell Biology, Kraków, Poland.

The last decade has seen a sharp increase in the number of scientific publications describing physiological and pathological functions of extracellular vesicles (EVs), a collective term covering various subtypes of cell-released, membranous structures, called exosomes, microvesicles, microparticles, ectosomes, oncosomes, apoptotic bodies, and many other names. However, specific issues arise when working with these entities, whose size and amount often make them difficult to obtain as relatively pure preparations, and to characterize properly. The International Society for Extracellular Vesicles (ISEV) proposed Minimal Information for Studies of Extracellular Vesicles ("MISEV") guidelines for the field in 2014. Read More

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https://www.tandfonline.com/doi/full/10.1080/20013078.2018.1
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http://dx.doi.org/10.1080/20013078.2018.1535750DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322352PMC
November 2018
35 Reads

Computed tomography imaging characteristics of primary atrial intimal sarcoma.

Clin Imaging 2018 Dec 10;54:112-115. Epub 2018 Dec 10.

Newark Beth Israel Medical Center, Radiology Department, USA. Electronic address:

We present a 36-year-old man who presented to our emergency department with acute onset shortness of breath and syncope. He was found to have a large left atrial mass on initial computed tomography (CT) which was confirmed by echocardiography. Tumor biopsy and attempted excision were performed, showing a primary cardiac spindle cell sarcoma that was unable to be resected, to which the patient eventually succumbed to. Read More

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http://dx.doi.org/10.1016/j.clinimag.2018.12.004DOI Listing
December 2018
2 Reads

Erratum to cardiac arrest due to coronary embolism from a metastatic sarcoma recovered through aspiration thrombectomy.

J Thorac Dis 2018 Nov;10(11):E791

Division of Cardiology, Department of Internal Medicine, College of Medicine, Gyeongsang National University, Gyeongsang National University Hospital, Jinju, Korea.

[This corrects the article DOI: 10.21037/jtd.2018. Read More

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http://jtd.amegroups.com/article/view/25162/19123
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http://dx.doi.org/10.21037/jtd.2018.10.77DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6297413PMC
November 2018
5 Reads

Stereotactic Body Radiation Therapy for the Treatment of Primary Cardiac Angiosarcoma Causing Hemodynamic Instability.

Pract Radiat Oncol 2019 01;9(1):5-8

Department of Radiation Oncology, Washington University School of Medicine in Saint Louis, Saint Louis, Missouri. Electronic address:

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http://dx.doi.org/10.1016/j.prro.2018.07.004DOI Listing
January 2019
1 Read

Paraneoplatic Obstruction of Descending Thoracic Aorta: A New Indication for Endovascular Surgery?

Ann Thorac Surg 2019 Jan 2. Epub 2019 Jan 2.

Department of Cardiac Surgery, School of Medicine, University "Federico II", Naples Italy.

We describe the rare case of a 61 years-old man, admitted in emergency to our department with visceral-organ and lower-limb malperfusion because an unknown retroperitoneal high grade undifferentiated pleomorphic sarcoma and a severe paraneoplastic obstruction of the descending thoracic aorta, treated with TEVAR The postoperative period was uneventful and patient was discharged within four days. At six- month follow-up CT scan showed complete patency of the descending thoracic aorta. This single case experience shows that TEVAR can be a less invasive and effective off-label alternative to exclude infiltrated and/or obstructed descending thoracic aorta avoiding conventional surgery. Read More

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http://dx.doi.org/10.1016/j.athoracsur.2018.12.004DOI Listing
January 2019
2 Reads

A Breath-Taking Diagnosis.

N Engl J Med 2019 01;380(1):81-87

From the Department of Medicine, Brigham and Women's Hospital, Boston.

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http://dx.doi.org/10.1056/NEJMcps1807721DOI Listing
January 2019
5 Reads

Retrospective analysis of 11 cases of primary cardiac valve tumors.

Anatol J Cardiol 2019 Jan;21(1):11-17

Department of Cardiovascular Surgery, The Second Affiliated Hospital (Xinqiao Hospital) of Chinese People's Liberation Army Medical University; Chongqing-China.

Objective: To explore the clinical features and surgical treatment experience of primary cardiac valve tumor.

Methods: The present study retrospectively analyzed the clinical data of 11 patients with primary valvular tumors who underwent surgical treatment in our department from 1980 to 2016. Echocardiography of preoperative patients was indicated as a heart valve tumor. Read More

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http://dx.doi.org/10.14744/AnatolJCardiol.2018.40325DOI Listing
January 2019
3 Reads

Evaluation of a cardiac sarcoma with CT multislice contrast-enhanced and 18FDG-PET/TC.

Radiol Case Rep 2019 Mar 17;14(3):368-371. Epub 2018 Dec 17.

Department of Biomedicine and Prevention, UOC of Diagnostic Imaging, University of Rome "Tor Vergata", Viale Oxford 81, Rome 00133, Italy.

We present the case of an adult male who arrived to our emergency room with progressive dyspnea that had been ongoing for 2 months. During the radiological investigation, we found a large intracardiac mass, which invaded the pericardium, pulmonary trunk, pulmonary arteries, and left ventricle. Studies done with the 18FDG-PET/CT scan helped us to determine the malignant nature of the mass and to suspect the diagnosis of rhabdomyosarcoma. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S19300433183051
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http://dx.doi.org/10.1016/j.radcr.2018.12.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299141PMC
March 2019
9 Reads

Primary cardiac sarcomas: A multi-national retrospective review.

Cancer Med 2019 Jan 21;8(1):104-110. Epub 2018 Dec 21.

Sarcoma Department, Mount Sinai Hospital, Toronto, Ontario, Canada.

Background: Primary cardiac sarcoma (PCS) is a rare but often fatal disease. The current study aimed to analyze the impact of baseline demographics, local and systemic therapies in a contemporary cohort.

Methods: Clinical records of PCS across six institutions in three continents were reviewed. Read More

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http://dx.doi.org/10.1002/cam4.1897DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346258PMC
January 2019
2 Reads

A Case of Undifferentiated Sarcoma in the Superior Vena Cava and Bilateral Cervical Veins.

Am J Case Rep 2018 Dec 19;19:1507-1514. Epub 2018 Dec 19.

Department of Pathology, Tachikawa General Hospital, Nagaoka, Niigata, Japan.

BACKGROUND Intimal sarcoma (IS) is a malignant mesenchymal tumor with predominantly intraluminal growth in large vessels and the heart. Due to the rarity of cases it often poses diagnostic problems in clinical and pathological settings. Although the classification of IS is still controversial, undifferentiated type of IS has recently been found to show immunohistochemical positivity with MDM2, CDK4, or PDGFRA and amplification of MDM2/CDK4 and PDGFRA. Read More

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https://www.amjcaserep.com/abstract/index/idArt/911659
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http://dx.doi.org/10.12659/AJCR.911659DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320552PMC
December 2018
9 Reads

aPKC controls endothelial growth by modulating c-Myc via FoxO1 DNA-binding ability.

Nat Commun 2018 12 17;9(1):5357. Epub 2018 Dec 17.

Laboratory for Cell Polarity and Organogenesis, Max Planck Institute for Heart and Lung Research, 61231, Bad Nauheim, Germany.

Strict regulation of proliferation is vital for development, whereas unregulated cell proliferation is a fundamental characteristic of cancer. The polarity protein atypical protein kinase C lambda/iota (aPKCλ) is associated with cell proliferation through unknown mechanisms. In endothelial cells, suppression of aPKCλ impairs proliferation despite hyperactivated mitogenic signaling. Read More

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http://www.nature.com/articles/s41467-018-07739-0
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http://dx.doi.org/10.1038/s41467-018-07739-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6297234PMC
December 2018
9 Reads

A rare case of intracardiac fibrosarcoma with myxoid features inducing venous occlusion in a dog - a case report.

BMC Vet Res 2018 Dec 14;14(1):398. Epub 2018 Dec 14.

Department of Pathology, University of Agricultural Sciences and Veterinary Medicine "Ion Ionescu de la Brad", Iași, Romania.

Background: In both humans and animals, cardiac fibrosarcoma is rare among primary cardiac malignant neoplasia. The overall prevalence of cardiac neoplasia in dogs is low, reported to be between 0.17% and 0. Read More

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http://dx.doi.org/10.1186/s12917-018-1735-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6295096PMC
December 2018
5 Reads

Cardiotoxicity with trabectedin in the treatment of advanced soft tissue sarcoma.

Anticancer Drugs 2019 Jan;30(1):110-115

Department of Oncology, Cambridge University Hospitals NHS Foundation Trust, Addenbrooke's Hospital, Cambridge Biomedical Campus, Cambridge, UK.

Trabectedin is used routinely in the palliative management of patients with advanced soft tissue sarcoma. It is not generally considered to be cardiotoxic, and there is no specific caution for its use in patients with a history of cardiac disease or risk factors. Here, we report six cases from a single academic centre where life-threatening cardiotoxicity occurred acutely during treatment with trabectedin. Read More

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http://dx.doi.org/10.1097/CAD.0000000000000693DOI Listing
January 2019
3 Reads
1.891 Impact Factor

Imaging and Surgical Treatment of Primary Pulmonary Artery Sarcoma.

Int J Cardiovasc Imaging 2018 Dec 8. Epub 2018 Dec 8.

Houston Methodist DeBakey Heart and Vascular Center, Houston, TX, USA.

Primary pulmonary artery sarcoma is a rare tumor originating from the pulmonary artery tree. Given the low incidence, few centers have reported on more than a handful of cases. Because of its rarity it is also commonly misdiagnosed as pulmonary embolism. Read More

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http://dx.doi.org/10.1007/s10554-018-1489-8DOI Listing
December 2018
1 Read

Retrospective analysis of 11 cases of primary cardiac valve tumors.

Anatol J Cardiol 2018 Dec 6. Epub 2018 Dec 6.

Department of Ultrasound Diagnosis, The Second Affiliated Hospital (Xinqiao Hospital) of Chinese People's Liberation Army Medical University; Chongqing-China.

Objective: To explore the clinical features and surgical treatment experience of primary cardiac valve tumor.

Methods: The present study retrospectively analyzed the clinical data of 11 patients with primary valvular tumors who underwent surgical treatment in our department from 1980 to 2016. Echocardiography of preoperative patients was indicated as a heart valve tumor. Read More

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http://dx.doi.org/10.14744/AnatolJCardiol.2018.40325DOI Listing
December 2018
1 Read

Perturbations in Traffic: Aberrant Nucleocytoplasmic Transport at the Heart of Neurodegeneration.

Cells 2018 Nov 26;7(12). Epub 2018 Nov 26.

Azrieli Faculty of Medicine, Bar-Ilan University, Safed 1311502, Israel.

Neurodegenerative diseases, such as amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), and Huntington's disease (HD), are characterized by intracellular aggregation of proteins. In the case of ALS and FTD, these protein aggregates are found in the cytoplasm of affected neurons and contain certain RNA-binding proteins (RBPs), namely the TAR DNA-binding protein of 43 kDa (TDP-43) and the fused in sarcoma (FUS) gene product. TDP-43 and FUS are nuclear proteins and their displacement to the cytoplasm is thought to be adverse in at least two ways: loss-of-function in the nucleus and gain-of-toxicity in the cytoplasm. Read More

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http://www.mdpi.com/2073-4409/7/12/232
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http://dx.doi.org/10.3390/cells7120232DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6316434PMC
November 2018
13 Reads

A 20 Year Experience with Resection of Primary Cardiac Tumors and Metastatic Tumors of the Heart.

Ann Thorac Surg 2018 Nov 21. Epub 2018 Nov 21.

Weill Cornell Medicine, 525 E 68(th) St, Suite M404, New York, NY 10065. Department of Cardiothoracic Surgery.

Background: Cardiac tumors are uncommon, occurring in less than one percent of the population, and are comprised of numerous tumor types. Management of certain tumors types such as sarcoma have evolved and improved in the recent era. We evaluate the outcomes of patients who underwent resection of benign or malignant cardiac tumors with a focused review of cardiac sarcomas. Read More

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http://dx.doi.org/10.1016/j.athoracsur.2018.10.023DOI Listing
November 2018
7 Reads

Periplocin, the most anti-proliferative constituent of Periploca sepium, specifically kills liposarcoma cells by death receptor mediated apoptosis.

Phytomedicine 2018 Dec 11;51:162-170. Epub 2018 Oct 11.

Institute of Pharmaceutical Sciences, Department of Pharmacognosy, University of Graz, Universitaetsplatz 4/1, 8010 Graz, Austria.

Background: During a screening of Chinese plants traditionally used for the treatment of cancer and related diseases, extracts of the root bark of Periploca sepium Bunge showed strong cytotoxic activity.

Purpose: Isolate and identify cytotoxic compounds from P. sepium and investigate the effects and mechanism of action on different cancer cell lines. Read More

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http://dx.doi.org/10.1016/j.phymed.2018.10.008DOI Listing
December 2018
14 Reads

The impact of postoperative therapy on primary cardiac sarcoma.

J Thorac Cardiovasc Surg 2018 Dec 6;156(6):2194-2203. Epub 2018 Jun 6.

Department of Medicine (Oncology), Stanford University School of Medicine, Stanford, Calif. Electronic address:

Objective: Primary cardiac sarcomas (PCS) are extremely rare, portend a very poor prognosis, and have limited outcomes data to direct management. This study evaluated the impact of postoperative chemotherapy and/or radiotherapy on survival for PCS.

Methods: A retrospective chart review was conducted of 12 patients diagnosed with and who underwent resection for PCS at a single institution between 2000 and 2016. Read More

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http://dx.doi.org/10.1016/j.jtcvs.2018.04.127DOI Listing
December 2018
12 Reads

Doxorubicin-induced heart failure in cancer patients: A cohort study based on the Korean National Health Insurance Database.

Cancer Med 2018 Dec 19;7(12):6084-6092. Epub 2018 Nov 19.

Department of Cardiology, Center for Clinical Specialty, National Cancer Center, Goyang-si, Korea.

Background: Doxorubicin is a typical anticancer drug that causes cardiomyopathy and heart failure (HF). The aim of our study was to investigate incidence, risk factors for doxorubicin-induced HF in Korean cancer patients and their survival rate, utilizing a nationwide population-based cohort.

Methods: We analyzed 58 541 cancer patients who received doxorubicin between 2003 and 2010. Read More

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http://doi.wiley.com/10.1002/cam4.1886
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http://dx.doi.org/10.1002/cam4.1886DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6308087PMC
December 2018
23 Reads

Frequency of Transition From Stage A to Stage B Heart Failure After Initiating Potentially Cardiotoxic Chemotherapy.

JACC Heart Fail 2018 Dec 7;6(12):1023-1032. Epub 2018 Nov 7.

Department of Internal Medicine, Section of Cardiovascular Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina; Department of Radiological Sciences, Wake Forest University School of Medicine, Winston-Salem, North Carolina; Department of Internal Medicine, Cardiology Division, Virginia Commonwealth University Health Sciences, Richmond, Virginia. Electronic address:

Objectives: This study sought to determine the prevalence of American Heart Association/American College of Cardiology Foundation (AHA/ACCF) heart failure (HF) stages after potentially cardiotoxic chemotherapy was initiated.

Background: For individuals receiving potentially cardiotoxic chemotherapy, the frequency of transitioning from Stage A to more advanced HF stages is not well described.

Methods: In 143 Stage A HF patients with breast cancer, lymphoma and leukemia, renal cell carcinoma, or sarcoma prior to and then at 3, 6, and 12 to 24 months after potentially cardiotoxic chemotherapy was initiated, we obtained blinded cardiac magnetic resonance measurements of left ventricular ejection fraction (LVEF). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22131779183064
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http://dx.doi.org/10.1016/j.jchf.2018.08.005DOI Listing
December 2018
8 Reads

Acute myeloid leukaemia relapse presenting as cardiac myeloid sarcoma.

BMJ Case Rep 2018 Nov 1;2018. Epub 2018 Nov 1.

Radiation Oncology, Barbara Ann Karmanos Cancer Institute, Detroit, Michigan, USA.

A 50-year-old woman previously diagnosed with acute myeloid leukaemia presented with a 3-month history of shortness of breath and a right-sided facial rash. A chest CT revealed an intracardiac mass in the right atrium extending into her superior and inferior vena cava. Surgery was performed to remove the mass and pathology was consistent with myeloid sarcoma. Read More

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http://dx.doi.org/10.1136/bcr-2018-224419DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6214378PMC
November 2018
5 Reads

[Synovial sarcoma of the right forearm].

Pan Afr Med J 2018 13;30:124. Epub 2018 Jun 13.

Service de Radiologie, Hôpital Militaire d'Instruction Mohammed V, Rabat, Maroc.

We report the case of a 60-year old female patient, followed up for hypertensive heart disease for 04 years, presenting to the Dermatological Department with a mass in the right forearm which had evolved and gradually increased in size over the previous year. Clinical examination showed soft rounded, voluminous painless, tumor-like crusted ulcerative lesion measuring 8 cm in large-diameter, fixed with respect to both planes, at the level of the mid-parts of the posterolateral area of the right forearm (A). Standard X-ray showed homogeneous opaque mass with sparing of the opposite cortex (B). Read More

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http://dx.doi.org/10.11604/pamj.2018.30.124.15900DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6201604PMC
November 2018
4 Reads

Modified autotransplant with three-dimensional printing for treatment of primary cardiac sarcoma.

J Thorac Cardiovasc Surg 2019 Feb 25;157(2):e41-e43. Epub 2018 Sep 25.

Cardiology Division, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil. Electronic address:

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http://dx.doi.org/10.1016/j.jtcvs.2018.08.087DOI Listing
February 2019
4 Reads

Plastic Bronchitis in an AIDS Patient with Pulmonary Kaposi Sarcoma.

Case Rep Pulmonol 2018 27;2018:9736516. Epub 2018 Sep 27.

Department of Medicine, Division of Infectious Diseases, UTH-SA, San Antonio, TX 78229, USA.

Plastic bronchitis is the expectoration of bronchial casts in the mold of the tracheobronchial tree. It is a rare occurrence of unknown etiology that has been primarily described in children with congenital heart disease. In this case report, we present the first reported case of plastic bronchitis in a patient with pulmonary Kaposi sarcoma and underlying HIV infection. Read More

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https://www.hindawi.com/journals/cripu/2018/9736516/
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http://dx.doi.org/10.1155/2018/9736516DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6180928PMC
September 2018
18 Reads

Functional Mitral Stenosis: Imposture of Primary Cardiac Intimal Sarcoma.

Cardiol Res 2018 Oct 7;9(5):307-313. Epub 2018 Oct 7.

Department of Cardiology, Cleveland Clinic Akron General, Akron, OH, USA.

Cardiac intimal sarcomas are extremely rare, remarkably aggressive and least reported type of primary malignant tumors of the heart. Cardiac intimal sarcomas are encountered more commonly in the large arterial blood vessels including pulmonary artery and aorta, and are extremely rare in the heart. The mainstay of treatment is achievement of tumor-free margins with surgical resection, which is associated with improved survival. Read More

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http://dx.doi.org/10.14740/cr748wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6188046PMC
October 2018
4 Reads

F-FDG-PET/CT imaging in cardiac tumors: illustrative clinical cases and review of the literature.

Ther Adv Med Oncol 2018 30;10:1758835918793569. Epub 2018 Aug 30.

Division of Medical Oncology, University of Bologna, Bologna, Italy.

Cardiac tumors are a very rare condition. Mostly, they are benign tumors (75%), with myxomas being the most frequent. The remaining 25% are malignant; either primary malignant sarcoma or secondary metastases. Read More

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http://dx.doi.org/10.1177/1758835918793569DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6188102PMC
August 2018
13 Reads

Cohort study of workers at a New Zealand agrochemical plant to assess the effect of dioxin exposure on mortality.

BMJ Open 2018 Oct 17;8(10):e019243. Epub 2018 Oct 17.

Summit Toxicology, Falls Church, Midland, Michigan, USA.

Objectives: To describe how the exposure to 2,3,7,8-tetrachlorodibenzo--dioxin (TCDD) influenced mortality in a cohort of workers who were exposed more recently, and at lower levels, than other cohorts of trichlorophenol process workers.

Design: A cohort study.

Setting: An agrochemical plant in New Zealand PARTICIPANTS: 1,599 men and women working between 1 January 1969 and 1 November 1988 at a plant producing the herbicide 2,4,5-trichlorophenoxyacetic acid (2,4,5-T) with TCDD as a contaminant. Read More

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http://dx.doi.org/10.1136/bmjopen-2017-019243DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6196860PMC
October 2018
3 Reads

Treatment of Hepatic Embryonal Undifferentiated Sarcoma With Cardiothoracic Involvement.

World J Pediatr Congenit Heart Surg 2018 Oct 14:2150135118775411. Epub 2018 Oct 14.

1 Department of Cardiovascular Surgery, Hospital Universitario y Politécnico La Fe, Valencia, Spain.

Thorough study is required to decide the appropriate management of hepatic tumors in children. We present a case report of a hepatic embryonal undifferentiated sarcoma with unfavorable prognosis in a nine-year-old girl. After undergoing a detailed cancer characteristics and extension study, a two-stage surgery approach was decided. Read More

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http://dx.doi.org/10.1177/2150135118775411DOI Listing
October 2018
8 Reads

Primary Cardiac Sarcoma Remission after Surgery: 5-Years Follow-up: Case Report.

Heart Surg Forum 2018 Sep 25;21(5):E401-E403. Epub 2018 Sep 25.

Department of Cardiovascular Surgery, Biruni University Hospital, Istanbul, Turkey.

Background: Primary cardiac sarcoma is a rare and atypical clinical entity. We present a patient with long-term remission after primary cardiac sarcoma resection.

Case Report: A 42-year-old previously healthy female presented to the emergency department after an effort-induced 30-minute episode of chest pain and extreme shortness of breath. Read More

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http://dx.doi.org/10.1532/hsf.1936DOI Listing
September 2018
18 Reads

Pericardial sarcoma.

BMJ Case Rep 2018 Oct 7;2018. Epub 2018 Oct 7.

Department of Cardiology, Faculty of Medicine, Alexandria University, Alexandria, Egypt.

Pericardial sarcomas are extremely rare aggressive neoplasms. Non-specific symptoms and incidental discovery are usually the rule. Multimodality imaging is extremely important for diagnosis and tissue characterisation of all cardiac masses. Read More

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http://casereports.bmj.com/lookup/doi/10.1136/bcr-2018-22611
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http://dx.doi.org/10.1136/bcr-2018-226112DOI Listing
October 2018
4 Reads

[Left atrial intimal sarcoma: A rare cause of acute heart failure].

Ann Cardiol Angeiol (Paris) 2018 Oct 2. Epub 2018 Oct 2.

Service de cardiologie, hôpital Taher Maamouri, Nabeul, Tunisie.

Primitive intimal sarcoma is a rare malignant cardiac tumor. Through the observation of a 41-year-old man who presented with an acute heart failure revealing a left atrial intimal sarcoma, we discuss different diagnostic and therapeutic modalities. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00033928183012
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http://dx.doi.org/10.1016/j.ancard.2018.08.020DOI Listing
October 2018
13 Reads

Long noncoding RNA Meg3 regulates cardiomyocyte apoptosis in myocardial infarction.

Gene Ther 2018 12 4;25(8):511-523. Epub 2018 Oct 4.

Institute for Cardiovascular Science & Department of Cardiovascular Surgery of the First Affiliated Hospital, Medical College, Soochow University, Suzhou, 215000, China.

Myocardial infarction (MI), with a major process of cardiomyocyte death, remains a leading cause of morbidity and mortality worldwide. To date, it has been shown that lncRNAs play important roles in cardiovascular pathology. However, the detailed studies on lncRNAs regulating cardiomyocyte death in myocardial infarction are still limited. Read More

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http://www.nature.com/articles/s41434-018-0045-4
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http://dx.doi.org/10.1038/s41434-018-0045-4DOI Listing
December 2018
29 Reads

Primary effusion lymphoma of the pleural space: Report of a rare complication of cardiac transplant with review of the literature.

Transpl Infect Dis 2019 Feb 30;21(1):e13005. Epub 2018 Oct 30.

Division of Pulmonary, Critical Care, and Sleep Medicine, Westchester Medical Center, Valhalla, New York.

Primary effusion lymphoma (PEL) is a rare mature B-cell non-Hodgkin's lymphoma arising in body cavities and presenting with effusions. It has been described predominantly in patients with impaired immunity from the acquired immunodeficiency syndrome and is associated with the Human Herpesvirus-8 (HHV-8). Seldom has PEL been diagnosed in persons negative for the human immunodeficiency virus (HIV), and in such cases it has occurred primarily in the setting of posttransplant immunosuppression. Read More

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http://dx.doi.org/10.1111/tid.13005DOI Listing
February 2019
16 Reads

Beyond Beck's Triad: A Rare Cause of Cardiac Tamponade and Hemoptysis.

Ochsner J 2018 ;18(3):271-273

Wayne State University, Detroit Medical Center Heart Hospital, Detroit, MI.

Background: Primary cardiac angiosarcoma (CAS) is a rare tumor with a dismal prognosis. Many patients present with noncardiac symptoms related to metastatic disease that could delay the diagnosis and deteriorate the outcome.

Case Report: A 36-year-old male presented with hemoptysis. Read More

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http://dx.doi.org/10.31486/toj.17.0081DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6162123PMC
January 2018
13 Reads

Hotspot Mutations Detectable by Next-generation Sequencing in Exhaled Breath Condensates from Patients with Lung Cancer.

Anticancer Res 2018 Oct;38(10):5627-5634

Department of Pathology, Faculty of Medicine, University of Helsinki, Helsinki, Finland

Background: Genetic alterations occurring in lung cancer are the basis for defining molecular subtypes and essential for targeted therapies. Exhaled breath condensate (EBC) is a form of non-invasive sample that, amongst components, contains DNA from pulmonary tissue. Next-generation sequencing (NGS) was herein used to analyze mutations in EBC from patients with lung cancer. Read More

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http://dx.doi.org/10.21873/anticanres.12897DOI Listing
October 2018
5 Reads

Primary undifferentiated pleomorphic cardiac sarcoma with amplification presenting as acute left-sided heart failure.

BMJ Case Rep 2018 Sep 30;2018. Epub 2018 Sep 30.

Department of Internal Medicine, Cedars-Sinai Medical Center, Los Angeles, California, USA.

Primary cardiac tumours are a rare clinical entity that can present with myriad of non-specific cardiopulmonary symptoms. We describe a case of a 61-year-old previously healthy woman who presented with progressive dyspnoea and lower extremity swelling, suggestive of acute left-sided heart failure. Transthoracic echocardiogram revealed a large, 3. Read More

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http://casereports.bmj.com/lookup/doi/10.1136/bcr-2018-22607
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http://dx.doi.org/10.1136/bcr-2018-226073DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6169688PMC
September 2018
15 Reads

Sequence analysis of cell-free DNA derived from cultured human bone osteosarcoma (143B) cells.

Tumour Biol 2018 Sep;40(9):1010428318801190

3 Human Metabolomics, Biochemistry Division, North-West University, Potchefstroom, South Africa.

The true importance of cell-free DNA in human biology, together with the potential scale of its clinical utility, is tarnished by a lack of understanding of its composition and origin. In investigating the cell-free DNA present in the growth medium of cultured 143B cells, we previously demonstrated that the majority of cell-free DNA is neither a product of apoptosis nor necrosis. In the present study, we investigated the composition and origin of this cell-free DNA population using next-generation sequencing. Read More

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http://dx.doi.org/10.1177/1010428318801190DOI Listing
September 2018
14 Reads

Cardiac Dedifferentiated Liposarcoma Requiring a Mitral Valve Replacement Complicated by Severe Paravalvular Leak: A Rare Case Report with Literature Review.

Case Rep Cardiol 2018 4;2018:2506368. Epub 2018 Sep 4.

Internal Medicine Department, Beaumont Hospital, Royal Oak, MI, USA.

Cardiac sarcomas have a high infiltrative and metastatic potential and are often associated with poor prognosis. These tumors are often identified incidentally by thoracic and cardiac imaging. However, when symptomatic, their presentation can differ based on the localized structural effects on the endocardium, myocardium, pericardium, and valves as well as on dynamic effects on the cardiac function. Read More

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http://dx.doi.org/10.1155/2018/2506368DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6142734PMC
September 2018
4 Reads

Predicting and Preventing Anthracycline-Related Cardiotoxicity.

Am Soc Clin Oncol Educ Book 2018 May(38):3-12

From the City of Hope, Duarte, CA; University of Alabama at Birmingham, Birmingham, AL.

Anthracyclines (doxorubicin, daunorubicin, epirubicin, and idarubicin) are among the most potent chemotherapeutic agents and have truly revolutionized the management of childhood cancer. They form the backbone of chemotherapy regimens used to treat childhood acute lymphoblastic leukemia, acute myeloid leukemia, Hodgkin lymphoma, Ewing sarcoma, osteosarcoma, and neuroblastoma. More than 50% of children with cancer are treated with anthracyclines. Read More

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http://dx.doi.org/10.1200/EDBK_100015DOI Listing
May 2018
4 Reads