5,535 results match your criteria Cardiac Sarcoma

Cardiac angiosarcoma: a case report of a young female with pulmonary metastasis.

Egypt Heart J 2022 May 21;74(1):40. Epub 2022 May 21.

Clinical Research Development Center, Taleghani and Imam Ali Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran.

Background: Angiosarcoma is a malignant rare tumor that originates from vascular endothelial cells that cover lymphatic or blood vessels. Cardiac angiosarcoma is the most prevalent sarcoma entail the heart. It has low incidence rate and poor prognosis. Read More

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Cardiac Angiosarcomas: Risk of Brain Metastasis and Hemorrhage Warrants Frequent Surveillance Imaging and Early Intervention.

Am J Clin Oncol 2022 Jun 26;45(6):258-263. Epub 2022 Apr 26.

Sarcoma Medical Oncology.

Purpose: We evaluated a cohort of patients with cardiac angiosarcomas (CA) who developed brain metastases (BM) to define outcomes and intracranial hemorrhage (IH) risk.

Methods: We reviewed 26 consecutive patients with BM treated between 1988 and 2020 identified from a departmental CA (n=103) database. Causes of death were recorded, and a terminal hemorrhage (TH) was defined as an IH that caused death or prompted a transfer to hospice. Read More

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Right Ventricular Involvement of an Aggressive Malignant Peripheral Nerve Sheath Tumor.

J Radiol Case Rep 2022 Jan 1;16(1):1-13. Epub 2022 Jan 1.

Department of Cardiology, West Virginia University Heart and Vascular Institute, Morgantown, WV, USA.

We present a case of a 58-year-old woman who had a painful right thigh mass for a few months. A transthoracic echocardiogram revealed no evidence of an intracardiac mass. She had a whole-body positron emission tomography/computed tomography scan two months later that revealed masses in her right lower extremity and a mass in her right ventricle that had not been initially reported. Read More

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January 2022

Trabectedin and Radiation Therapy for Cardiac Metastasis From Leiomyosarcoma: A Case Report and Review of the Literature.

Front Oncol 2022 28;12:838114. Epub 2022 Apr 28.

Oncology 1 Unit, Department of Oncology, Veneto Institute of Oncology IOV - IRCCS, Padua, Italy.

Leiomyosarcoma (LMS) is one of the most frequent subtypes of soft-tissue sarcomas (STSs). Metastatic spread to the heart in cancer patients carries a poor prognosis and there is no known effective treatment. Cardiac metastases of STSs are very rare. Read More

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Cancer Therapy-Related Cardiac Dysfunction in Patients Treated with a Combination of an Immune Checkpoint Inhibitor and Doxorubicin.

Cancers (Basel) 2022 May 7;14(9). Epub 2022 May 7.

Division of Oncology, Yonsei University College of Medicine, Seoul 03722, Korea.

Backgrounds: There are scarce data on whether immune checkpoint inhibitors (ICIs) increase the risk of cardiac dysfunction when used with cardiotoxic agents. Thus, we evaluated cardiac dysfunction in patients with sarcoma receiving doxorubicin with or without ICI using echocardiography and left ventricular global longitudinal strain (LVGLS).

Methods: A total of 95 patients were included in this study. Read More

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Cardio-facio-cutaneous syndrome and gastrointestinal defects: report on a newborn with 19p13.3 deletion including the MAP 2 K2 gene.

Ital J Pediatr 2022 May 4;48(1):65. Epub 2022 May 4.

Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties "G. D'Alessandro", University of Palermo, Palermo, Italy.

Background: Cardio-facio-cutaneous syndrome (CFCS) belongs to RASopathies, a group of conditions caused by mutations in genes encoding proteins of the rat sarcoma/mitogen-activated protein kinase (RAS/MAPK) pathway. It is a rare syndrome, with about 300 patients reported. Main clinical manifestations include facial dysmorphisms, growth failure, heart defects, developmental delay, and ectodermal abnormalities. Read More

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[Primary cardiac angiosarcoma diagnosed by myocardial biopsy guided by intracardiac echocardiography: a case report].

Zhonghua Nei Ke Za Zhi 2022 May;61(5):572-574

Department of Cardiology, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China.

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Cardiac Involvement of Metastatic Clear Cell Sarcoma: A Multimodality Imaging Report.

Circ Cardiovasc Imaging 2022 May 28;15(5):e013902. Epub 2022 Apr 28.

Department of Biomedical Sciences and Morphological and Functional Imaging, University Hospital Messina, Italy (T.D., G.M.B., A.M., L.R.M.L., A.B., S.M.).

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The Retrograde Left Atrial Tumour Embolism In Thepatient With Metastatic Extremity Chondrosarcoma.

J Ayub Med Coll Abbottabad 2022 Jan-Mar;34(1):207-210

Muğla Sıtkı Koçman University, Turkey.

A 34 years old male, labourer by occupation was brought to our trauma centre in an inebriated state with a history of fall from a height of approximately 10 feet. He complained of pain in the right elbow. A complete examination of the affected upper limb revealed an ipsilateral anterior shoulder dislocation and a posterior elbow dislocation with no other concomitant injuries. Read More

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Mediastinal Primary Synovial Sarcoma With Postoperative Pericardial Recurrence in a Previously Treated Angiofibroma.

Cureus 2022 Mar 9;14(3):e23014. Epub 2022 Mar 9.

Department of Gastroenterology, Kyoto Second Red Cross Hospital, Kyoto, JPN.

Synovial sarcoma is a malignant soft tissue tumor that often occurs near the limb joints. Here, we report a case of a patient with a synovial sarcoma that occurred in the mediastinum. The initial pathological diagnosis was suspected angiofibroma after surgical resection. Read More

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Classic KSHV/HHV-8-positive Primary Effusion Lymphoma (PEL): A Systematic Review and Meta-Analysis of Case Reports.

Mediterr J Hematol Infect Dis 2022 1;14(1):e2022020. Epub 2022 Mar 1.

Department of Radiological, Oncological and Pathological Sciences, Sapienza University, Rome.

Primary effusion lymphoma (PEL) is a large B-cell lymphoma growing within body-cavities caused by the Kaposi sarcoma-associated herpesvirus (KSHV)/human herpesvirus-8 (KSHV/HHV-8). It is mainly reported in HIV-infected patients. The uncommon occurrence in the elderly supports a form paralleling classic Kaposi sarcoma (KS), i. Read More

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Metastatic osteosarcoma tumor thrombus in a Cavalier King Charles Spaniel presenting with dyspnea.

J Vet Cardiol 2022 Mar 23;41:209-215. Epub 2022 Mar 23.

Langford Vets, University of Bristol, Stock Lane, Lower Langford, North Somerset, BS40 5DU, United Kingdom; Highcroft Veterinary Referrals, 615 Wells Road, Whitchurch, Bristol, Avon, BS14 9BE, United Kingdom. Electronic address:

A six-year-seven-month-old female neutered Cavalier King Charles Spaniel was referred for the investigation of progressive dyspnea and hyphema in the right eye with secondary glaucoma. Previous medical history included a high-grade soft tissue spindle cell sarcoma removed from the cranial sternal region one year before. On presentation at the referral hospital, the dog was tachypneic and dyspneic. Read More

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Inward and outward currents of native and cloned K(ATP) channels (Kir6.2/SUR1) share single-channel kinetic properties.

Biochem Biophys Rep 2022 Jul 8;30:101260. Epub 2022 Apr 8.

The Rolf Luft Research Center for Diabetes and Endocrinology, Sweden.

Background: The ATP-sensitive K (K(ATP)) channel is found in a variety of tissues extending from the heart and vascular smooth muscles to the endocrine pancreas and brain. Common to all K(ATP) channels is the pore-forming subunit Kir6.x, a member of the family of small inwardly rectifying K channels, and the regulatory subunit sulfonylurea receptor (SURx). Read More

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Development of a Machine Learning-Based Predictive Model for Lung Metastasis in Patients With Ewing Sarcoma.

Front Med (Lausanne) 2022 1;9:807382. Epub 2022 Apr 1.

Faculty of Medicine, Macau University of Science and Technology, Macau, Macau SAR, China.

Background: This study aimed to develop and validate machine learning (ML)-based prediction models for lung metastasis (LM) in patients with Ewing sarcoma (ES), and to deploy the best model as an open access web tool.

Methods: We retrospectively analyzed data from the Surveillance Epidemiology and End Results (SEER) Database from 2010 to 2016 and from four medical institutions to develop and validate predictive models for LM in patients with ES. Patient data from the SEER database was used as the training group ( = 929). Read More

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Massive primary cardiac synovial sarcoma of the left atrium: a case report.

J Cardiothorac Surg 2022 Apr 14;17(1):76. Epub 2022 Apr 14.

Division of Cardiac Surgery, Department of Surgery, Johns Hopkins Hospital, Zayed Tower, 1800 Orleans Street, Baltimore, MD, 21287, USA.

Background: Synovial sarcomas are tumors typically located in the extremities and characterized by a t(X;18)(p11.2;q11.2) chromosomal translocation. Read More

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Spindle-cell sarcoma of the heart: A case report of a rare cause of cardiac mass.

Ann Card Anaesth 2022 Apr-Jun;25(2):220-224

Department of Cardiac Anaesthesia and Surgery, Wockhardt Hospitals, Mumbai, Maharashtra, India.

Spindle cell sarcoma of heart are the least reported primary cardiac tumours. We present a case of a 60-year-old man reported to us following successful resuscitation after cardiac arrest. This patient presented with symptoms of dyspnoea on exertion. Read More

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Surgical treatment of primary cardiac tumors: 20-year single center experience.

Kardiochir Torakochirurgia Pol 2022 Mar 24;19(1):36-40. Epub 2022 Mar 24.

Department of Cardiac Surgery, Charles University, Faculty of Medicine and University Hospital, Hradec Kralove, Czech Republic.

Introduction: Primary cardiac tumors are a rare condition presenting with a variety of symptoms. The outcomes of their surgical treatment in the modern era from central Europe have not been recently reported.

Aim: To evaluate the short- and long-term outcomes of the cardiac tumor operations at our department throughout the last 20 years. Read More

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Occurrence of Second Primary Malignancies in Patients With Primary Optic Nerve Gliomas: A Surveillance, Epidemiology, and End Results Analysis.

Cancer Diagn Progn 2021 Nov-Dec;1(5):393-398. Epub 2021 Nov 3.

Texas Tech University Health Sciences Center - Paul L. Foster School of Medicine, El Paso, TX, U.S.A.

Background/aim: Advanced understanding of screening and therapeutic modalities acts as provision for increased survival in patients diagnosed with optic nerve gliomas. Secondary primary malignancies (SPMs) in patients diagnosed with primary optic nerve glioma (OPG) are currently an uncharacterized frontier. This US national database analysis highlights the incidences of SPMs in patients diagnosed with primary OPG. Read More

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November 2021

Diagnosis of Pulmonary Artery Sarcoma with Multi-modality Imaging.

Turk Kardiyol Dern Ars 2022 03;50(2):155-158

Department of Cardiology, Koşuyolu Kartal Heart Training and Research Hospital, İstanbul, Turkey.

Pulmonary artery sarcoma is an extremely uncommon malignancy with a poor prognosis. It is often difficult to distinguish it from pulmonary thromboembolic disease because of nonspe cific signs and symptoms as well as similar imaging findings. We present a 46-year-old man who had initially been diagnosed with presumed asthma that later proved to be pulmonary artery sarcoma. Read More

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HIF-1α-regulated lncRNA-TUG1 promotes mitochondrial dysfunction and pyroptosis by directly binding to FUS in myocardial infarction.

Cell Death Discov 2022 Apr 8;8(1):178. Epub 2022 Apr 8.

Department of Cardiology, Affiliated Hospital of Guilin Medical University, Guilin, 541001, Guangxi, Zhuang Autonomous Region, P. R. China.

Myocardial infarction (MI) is a fatal heart disease that affects millions of lives worldwide each year. This study investigated the roles of HIF-1α/lncRNA-TUG1 in mitochondrial dysfunction and pyroptosis in MI. CCK-8, DHE, lactate dehydrogenase (LDH) assays, and JC-1 staining were performed to measure proliferation, reactive oxygen species (ROS), LDH leakage, and mitochondrial damage in hypoxia/reoxygenation (H/R)-treated cardiomyocytes. Read More

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Development and Validation of a Novel Clinical Prediction Model to Predict the Risk of Lung Metastasis from Ewing Sarcoma for Medical Human-Computer Interface.

Comput Intell Neurosci 2022 29;2022:1888586. Epub 2022 Mar 29.

Faculty of Medicine, Macau University of Science and Technology, Macau, China.

Background: This study aimed at establishing and validating a quantitative and visual prognosis model of Ewing Sarcoma (E.S.) via a nomogram. Read More

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Risk of coronary stenosis after adjuvant radiotherapy for breast cancer.

Strahlenther Onkol 2022 Apr 7. Epub 2022 Apr 7.

Department of Surgical and Perioperative Sciences/Surgery, Umeå University, Umeå, Sweden.

Purpose: Adjuvant radiotherapy (RT) for breast cancer is associated with an increased risk of ischemic heart disease. We examined the risk of coronary artery stenosis in a large cohort of women with breast cancer receiving adjuvant RT.

Methods: A cohort of women diagnosed with breast cancer between 1992 and 2012 in three Swedish health care regions (n = 57,066) were linked to the Swedish Coronary Angiography and Angioplasty Registry (SCAAR) to identify women receiving RT who subsequently underwent a percutaneous coronary intervention (PCI) due to coronary stenosis. Read More

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Clinical Application of Artificial Intelligence: Auto-Discerning the Effectiveness of Lidocaine Concentration Levels in Osteosarcoma Femoral Tumor Segment Resection.

J Healthc Eng 2022 28;2022:7069348. Epub 2022 Mar 28.

Department of Anesthesiology, Yantaishan Hospital, Yantai 264003, Shandong, China.

Adolescents and children worldwide are threatened by osteosarcoma, a tumor that predominantly affects the long bone epiphysis. Osteosarcoma is the most common and highly malignant bone tumor in youngsters. Early tumor detection is the key to effective treatment of this disease. Read More

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Radical surgery for a mitral valve intimal sarcoma: serial patch repair of the annulus and atrium.

Interact Cardiovasc Thorac Surg 2022 Mar 28. Epub 2022 Mar 28.

Department of Cardiovascular Surgery, Hitachi General Hospital, Hitachi, Japan.

We report the rare case of a 48-year-old woman with a cardiac intimal sarcoma occupying the mitral valve and the left atrial roof. We resected the tumour in one block without residual lesions. The anterior mitral annulus and left atrial roof were serially repaired with the bovine pericardium, and a mechanical prosthesis was implanted in the reconstructed mitral annulus. Read More

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Multimodality Imaging for the Evaluation of an Undifferentiated Pleomorphic Sarcoma Presenting as Cardioembolic Stroke.

Case Rep Cardiol 2022 15;2022:2749303. Epub 2022 Mar 15.

Shipley Cardiothoracic Center, Lee Health System, Fort Myers, FL, USA.

Background: Cancer and ischemic stroke are associated with significant morbidity and mortality. Hypercoagulability, disseminated intravascular coagulation, venous-to-arterial embolism, and non-bacterial thrombotic endocarditis are among recognized mechanisms. Emboli to the brain, or to other organs, are known to occur as a consequence of liberated thrombotic debris originating from the thrombogenic surface of intracardiac neoplastic entities. Read More

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Mechanism of Zhen Wu Decoction in the Treatment of Heart Failure Based on Network Pharmacology and Molecular Docking.

Evid Based Complement Alternat Med 2022 15;2022:4877920. Epub 2022 Mar 15.

Emergency Medicine Department, Zhejiang Hospital of Integrated Traditional Chinese and Western Medicine, Hangzhou, China.

Heart failure (HF) is a serious manifestation or advanced stage of various cardiovascular diseases, and its mortality and rehospitalization rate are still on the rise in China. Based on the network pharmacology method, 59 components of Zhen Wu decoction (ZWD) and 83 target genes related to HF were obtained. Through the PPI network, four potential therapeutic targets were identified: AKT1, IL6, JUN, and MAPK8. Read More

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A Bout of High-Intensity Interval Training (HIIT) in Children and Adolescents during Acute Cancer Treatment-A Pilot Feasibility Study.

Cancers (Basel) 2022 Mar 12;14(6). Epub 2022 Mar 12.

Kinderklinik München Schwabing, Department of Pediatrics and Children's Cancer Research Center, TUM School of Medicine, Technical University of Munich, 80804 Munich, Germany.

Low- and moderate-intensity exercise is safe and feasible during childhood cancer treatment. The feasibility of a bout of high-intensity interval training (HIIT) in this population has not been analyzed to date. Pediatric cancer patients aged between 6 and 18 years were selected based on clinical conditions to perform ten sets of 15 s HIIT (>90% of estimated maximal heart rate (HR)) and 1 min active recovery on a bicycle ergometer within the first three chemotherapy courses. Read More

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Assessment of Pazopanib-Related Heart Failure in Patients With Advanced Soft Tissue Sarcoma - A Single Institute Analysis.

Circ J 2022 Mar 18. Epub 2022 Mar 18.

Department of Medical Oncology, The Cancer Institute Hospital of Japanese Foundation for Cancer Research.

Background: Heart failure (HF) is one of the potential adverse events of pazopanib treatment for soft tissue sarcoma (STS), but detailed reports of such HF cases are scarce. This study determined the incidence and risk factors of HF following pazopanib treatment for STS at our Institute and the clinical outcomes.Methods and Results:This study retrospectively analyzed the cases of STS patients treated with pazopanib (n=151) between 2012 and 2020. Read More

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Primary and metastatic primitive neuroectodermal tumor of the heart: A systematic review.

Asian Cardiovasc Thorac Ann 2022 Mar 21:2184923221083434. Epub 2022 Mar 21.

Department of Internal Medicine, 440827Iran University of Medical Sciences, Tehran, Iran.

Objective: Primary and metastatic primitive neuroectodermal tumors of the pericardium are uncommon. Two cases are presented and discussed.

Methods: The cases of a 17- and 38-year-old male patients with neuroectodermal tumors of the pericardium are presented. Read More

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Comparing six cardiovascular risk prediction models in Haiti: implications for identifying high-risk individuals for primary prevention.

BMC Public Health 2022 03 19;22(1):549. Epub 2022 Mar 19.

Division of General Internal Medicine, Department of Medicine, Weill Cornell Medicine, New York, NY, USA.

Background: Cardiovascular diseases (CVD) are rapidly increasing in low-middle income countries (LMICs). Accurate risk assessment is essential to reduce premature CVD by targeting primary prevention and risk factor treatment among high-risk groups. Available CVD risk prediction models are built on predominantly Caucasian risk profiles from high-income country populations, and have not been evaluated in LMIC populations. Read More

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