5,075 results match your criteria Cardiac Sarcoma


Genetic aberrations and molecular biology of cardiac sarcoma.

Ther Adv Med Oncol 2020 18;12:1758835920918492. Epub 2020 May 18.

Department of Specialized, Experimental and Diagnostic Medicine, Medical Oncology Unit, Sant'Orsola-Malpighi Hospital, University of Bologna, Via Massarenti, 9, Bologna, Bologna 40138, Italy.

Cardiac tumors are rare and complex entities. Early assessment and differentiation between non-neoplastic and neoplastic masses, be they benign or malignant, is essential for guiding diagnosis, determining prognosis, and planning therapy. Cardiac sarcomas represent the most frequent primary malignant histotype. Read More

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http://dx.doi.org/10.1177/1758835920918492DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7238448PMC

Anthracycline-induced cardiotoxicity and renin-angiotensin-aldosterone system-from molecular mechanisms to therapeutic applications.

Heart Fail Rev 2020 May 30. Epub 2020 May 30.

Department of Experimental and Clinical Physiology, Laboratory of Centre for Preclinical Research, Medical University of Warsaw, Warsaw, Poland.

Few millions of new cancer cases are diagnosed worldwide every year. Due to significant progress in understanding cancer biology and developing new therapies, the mortality rates are decreasing with many of patients that can be completely cured. However, vast majority of them require chemotherapy which comes with high medical costs in terms of adverse events, of which cardiotoxicity is one of the most serious and challenging. Read More

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http://dx.doi.org/10.1007/s10741-020-09977-1DOI Listing

Complete Resection of Cardiac Angiosarcoma Invading Right Heart and Right Coronary Artery.

Ann Thorac Surg 2020 May 23. Epub 2020 May 23.

Department of Thoracic and Cardiovascular Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea. Electronic address:

Complete surgical resection is the most critical factor to achieve better long-term outcomes in treating primary cardiac sarcomas, however, it is oftentimes hampered when there is extensive tumor involvement into important cardiac apparatus. Here, we report a case of successful complete resection of a cardiac sarcoma infiltrating the right atrio-ventricle, tricuspid valve and right coronary artery. Read More

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http://dx.doi.org/10.1016/j.athoracsur.2020.04.026DOI Listing

Primary sarcoma of the heart: case report and literature review.

J Cardiothorac Surg 2020 May 19;15(1):104. Epub 2020 May 19.

Department of Radiation Oncology, Radboud University Medical Center, Geert Grooteplein Zuid 32, 6525 GA, Nijmegen, The Netherlands.

Background: Primary cardiac tumors are extremely rare. Most primary cardiac tumors are benign and around one quarter is malign. Sarcomas are accounting for 95% of these malign tumors and they show different histologies. Read More

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http://dx.doi.org/10.1186/s13019-020-01157-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7236931PMC

Left Atrial High-grade Sarcoma With Focal Osteosarcomatous Differentiation.

Cureus 2020 Apr 13;12(4):e7660. Epub 2020 Apr 13.

Cardiology, Palmetto General Hospital, Hialeah, USA.

Approximately 75% of cardiac tumors are benign, and 25% are malignant cardiac tumors. Of these, sarcomas are extremely rare and have been described in isolated case reports. Due to its rarity, there is no published guideline for the management of this pathological entity. Read More

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http://dx.doi.org/10.7759/cureus.7660DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7219016PMC

Thirty-Day Outcomes after Surgery for Primary Sarcomas of the Extremities: An Analysis of the NSQIP Database.

J Oncol 2020 13;2020:7282846. Epub 2020 Jan 13.

Department of Orthopaedic Surgery, UT Southwestern Medical Center, 1801 Inwood Road, Dallas, TX 75390, USA.

Background: Primary bone and soft tissue sarcomas are rare tumors requiring wide surgical resection and reconstruction to achieve local control. Postoperative complications can lead to delays in adjuvant therapy, potentially affecting long-term oncologic outcomes. Understanding postoperative complication risks is essential; however, past studies are limited by small sample sizes. Read More

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http://dx.doi.org/10.1155/2020/7282846DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7201584PMC
January 2020

Post Heart Transplantation Lymphoproliferative Diseases (PLDs) and the diagnostic role of [18f] FDG- PET/CT.

Minerva Med 2020 May 14. Epub 2020 May 14.

Department of Precision Medicine, University of Campania Luigi Vanvitelli, Naples, Italy.

Introduction: The incidence of cancer is higher in transplant patients than in the normal population, mostly due to the assumption of immunosuppressants able to reduce the possibility of rejection. In addition, immunocompromised patients have a greater susceptibility to EBV, HPV and HIV, infectious agents that by themselves may favor the onset of malignancies. Post-Transplant Lymphoproliferative Diseases (PLDs) are among the most frequent neoplasms in transplant patients which like other aggressive neoplasms may be identified by the [18f] fluoro-D-deoxyglucose positron emission tomography/computed tomography (FDG- PET/CT). Read More

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http://dx.doi.org/10.23736/S0026-4806.20.06607-0DOI Listing
May 2020
1.202 Impact Factor

Right Atrial Intimal Sarcoma on 18F-FDG PET/CT.

Clin Nucl Med 2020 May 11. Epub 2020 May 11.

Nuclear Medicine Department, University Hospital Antwerp, Edegem, Belgium.

A right atrial mass was discovered with transthoracic cardiac ultrasound in a complaint-free, 81-year-old man at his yearly cardiological checkup. Further investigation of the mass with transesophageal cardiac ultrasound showed a well-defined nodular mass of approximately 3 × 3 cm, in close proximity to the posterior wall of the right atrium. The patient underwent an F-FDG PET/CT, which showed a right atrial mass with very high FDG uptake, suggesting a malignant process. Read More

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http://dx.doi.org/10.1097/RLU.0000000000003051DOI Listing

Differential diagnosis of heart tumours.

Cesk Patol 2020 ;56(1):18-25

Cardiac tumours represent a wide spectrum of neoplastic and non-neoplastic masses. Plenty of them, especially primary cardiac neoplasias, are rare diseases. Last revision of WHO classification introduced several changes in their histopathological assessment. Read More

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January 2020

Survival Differences in Men and Women With Primary Malignant Cardiac Tumor: An Analysis Using the Surveillance, Epidemiology and End Results (SEER) Database From 1973 to 2015.

J Am Heart Assoc 2020 May 10;9(10):e014846. Epub 2020 May 10.

Department of Internal Medicine University of Nevada Reno School of Medicine Reno NV.

Background No data are available on sex disparities in prevalence and survival for primary malignant cardiac tumors (PMCT). This study aimed to compare male and female PMCT prevalence and long-term survival rates. Methods and Results We utilized the Surveillance, Epidemiology, and End Results (SEER) 18 database from the National Cancer Institute for all PMCTs diagnosed between 1973 and 2015. Read More

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http://dx.doi.org/10.1161/JAHA.119.014846DOI Listing

Extraosseus Ewing's Sarcoma in Pancreas: A Review.

Cureus 2020 Apr 1;12(4):e7505. Epub 2020 Apr 1.

Internal Medicine, Chicago Medical School, Rosalind Franklin University, North Chicago, USA.

Primitive neuroectodermal tumors (PNET, previously referred to as peripheral neuroepithelioma) are rare malignant tumors with various degrees of differentiation belonging to the Ewing's family of sarcomas. They are classified as round cell tumors arising from soft tissues. In rare instances, PNETs may arise from solid organs containing neuroendocrine cells of kidney, bladder, heart, lungs, parotid glands and pancreas. Read More

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http://dx.doi.org/10.7759/cureus.7505DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7195206PMC

Primary undifferentiated spindle cell sarcoma obstructing the right ventricular outflow tract.

J Cardiothorac Surg 2020 May 4;15(1):71. Epub 2020 May 4.

Department of Pathology, Bundang Jesaeng Hospital, Seongnam-si, Gyeonggi-do, Republic of Korea.

Background: Primary undifferentiated spindle cell sarcoma in the right ventricle is an extremely rare tumor. Radical surgical excision is the optimal treatment for long-term survival due to poor response to chemotherapy or radiotherapy at an advanced stage.

Case Presentation: A 42-year-old man with no previous medical history presented with mild dyspnea on exertion and abdominal distension that lasted a week. Read More

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http://dx.doi.org/10.1186/s13019-020-01129-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7199296PMC

Giant Cell Sarcomas in Domestic Rabbits ().

Vet Pathol 2020 Apr 29:300985820921814. Epub 2020 Apr 29.

Michigan State University, Lansing, MI, USA.

Multinucleated giant cells (MGCs) are a prominent histological feature of various mesenchymal neoplasms and are often considered a criterion of malignancy. Mesenchymal neoplasms with MGCs for which the cell lineage is unclear generally are referred to as giant cell sarcomas. Here we characterize the gross, histologic, and immunohistochemical features of 90 giant cell sarcomas in domestic pet rabbits. Read More

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http://dx.doi.org/10.1177/0300985820921814DOI Listing

Sarkom i hjertet.

Tidsskr Nor Laegeforen 2020 Apr 20;140(6). Epub 2020 Apr 20.

Background: Although very rare, cardiac sarcoma is the most common malignant cardiac tumour. Cardiac tumours may present with constitutional symptoms and this can lead to delayed diagnosis.

Case Presentation: A woman in her late twenties was admitted to the acute psychiatric ward with suspected depressive psychosis. Read More

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http://dx.doi.org/10.4045/tidsskr.19.0455DOI Listing

Subclinical Cardiac Dysfunction in Childhood Cancer Survivors on 10-Years Follow-Up Correlates With Cumulative Anthracycline Dose and Is Best Detected by Cardiopulmonary Exercise Testing, Circulating Serum Biomarker, Speckle Tracking Echocardiography, and Tissue Doppler Imaging.

Front Pediatr 2020 31;8:123. Epub 2020 Mar 31.

Department of Congenital Heart Disease and Pediatric Cardiology, German Heart Center Munich, Technical University Munich, Munich, Germany.

Survivors of childhood cancer are at risk for anthracycline- and/or radiotherapy-induced cardiotoxicity. The aim of this study was to assess clinical, laboratory, and imaging parameters of subclinical cardiovascular disease in childhood cancer survivors. Patients underwent cardiopulmonary exercise test (CPET), laboratory testing, transthoracic echocardiography (TTE) with tissue doppler imaging (TDI) and speckle tracking. Read More

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http://dx.doi.org/10.3389/fped.2020.00123DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7136405PMC

Cardiac sarcoma attached to pacemaker lead.

J Card Surg 2020 May 15;35(5):1148-1151. Epub 2020 Apr 15.

Department of Anaesthesia, National University Hospital, Singapore, Singapore.

Background And Aim: Cardiac sarcoma is a rare condition and may mimic atrial myxoma. We present a case report of a man with a cardiac sarcoma.

Method: Case report presentation. Read More

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http://dx.doi.org/10.1111/jocs.14541DOI Listing

Impact of different treatment techniques for pediatric Ewing sarcoma of the chest wall: IMRT, 3DCPT, and IMPT with/without beam aperture.

J Appl Clin Med Phys 2020 Apr 8. Epub 2020 Apr 8.

Department of Radiation Oncology, University of Florida, Gainesville, FL, USA.

Purpose: To evaluate the dosimetric differences between photon intensity-modulated radiation therapy (IMRT) plans, 3D conformal proton therapy (3DCPT), and intensity-modulated proton therapy (IMPT) plans and to investigate the dosimetric impact of different beam spot size and beam apertures in IMPT for pediatric Ewing sarcoma of the chest wall.

Methods And Materials: Six proton pediatric patients with Ewing sarcoma in the upper, middle, and lower thoracic spine regions as well as upper lumbar spine region were treated with 3DCPT and retrospectively planned with photon IMRT and IMPT nozzles of different beam spot sizes with/without beam apertures. The plan dose distributions were compared both on target conformity and homogeneity, and on organs-at-risk (OARs) sparing using QUANTEC metrics of the lung, heart, liver, and kidney. Read More

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http://dx.doi.org/10.1002/acm2.12870DOI Listing

Effect of Doxorubicin Plus Olaratumab vs Doxorubicin Plus Placebo on Survival in Patients With Advanced Soft Tissue Sarcomas: The ANNOUNCE Randomized Clinical Trial.

JAMA 2020 04;323(13):1266-1276

Sarcoma Unit, Royal Marsden NHS Foundation Trust and Institute of Cancer Research, London, United Kingdom.

Importance: Patients with advanced soft tissue sarcoma (STS) have a median overall survival of less than 2 years. In a phase 2 study, an overall survival benefit in this population was observed with the addition of olaratumab to doxorubicin over doxorubicin alone.

Objective: To determine the efficacy of doxorubicin plus olaratumab in patients with advanced/metastatic STS. Read More

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http://dx.doi.org/10.1001/jama.2020.1707DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7139275PMC

Primary Cardiac Undifferentiated High-Grade Intimal Pleomorphic Sarcoma: A Case Series Report.

Cardiol Res 2020 Apr 10;11(2):129-133. Epub 2020 Mar 10.

Division of Cardiology, Atlantic Health System, Overlook Medical Center, 99 Beauvoir Ave, Summit, NJ 07901, USA.

We report two patients with primary cardiac sarcomas. The first patient was admitted for dyspnea on exertion secondary to congestive heart failure. She was later diagnosed with intimal pleomorphic sarcoma involving the right ventricular outflow tract extending into the pulmonary artery, which was further complicated by metastasis to the lung. Read More

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http://dx.doi.org/10.14740/cr1029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7092767PMC

Extracellular vesicular microRNAs as potential biomarker for early detection of doxorubicin-induced cardiotoxicity.

J Vet Intern Med 2020 May 7;34(3):1260-1271. Epub 2020 Apr 7.

Department of Clinical Sciences, Cummings School of Veterinary Medicine at Tufts University, North Grafton, Massachusetts, USA.

Background: Long-term use of doxorubicin (DOX) is limited by cumulative dose-dependent cardiotoxicity.

Objectives: Identify plasma extracellular vesicle (EV)-associated microRNAs (miRNAs) as a biomarker for cardiotoxicity in dogs by correlating changes with cardiac troponin I (cTnI) concentrations and, echocardiographic and histologic findings.

Animals: Prospective study of 9 client-owned dogs diagnosed with sarcoma and receiving DOX single-agent chemotherapy (total of 5 DOX treatments). Read More

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http://dx.doi.org/10.1111/jvim.15762DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7255649PMC
May 2020
1.879 Impact Factor

Nontuberculous extensive constrictive pericarditis calcarea impairing right ventricular filling in an HIV-infected patient: the key role of computed tomography imaging.

J Cardiovasc Med (Hagerstown) 2020 Apr 3. Epub 2020 Apr 3.

Department of Radiology, Innsbruck Medical University, Innsbruck, Austria.

: We report a rare case of extensive pericardial calcifications most likely related to HIV-pericarditis, since all other causes, including infectious causes (especially tuberculous pericarditis), have been excluded. The Kaposi sarcoma was confined to both lower extremities, and even the therapy (antiretroviral therapy and later chemotherapy) is unlikely to have played a role in the cause of the pericarditis. Read More

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http://dx.doi.org/10.2459/JCM.0000000000000966DOI Listing

Primary cardiac undifferentiated pleomorphic sarcoma: an alarming cause of lower back pain.

BMJ Case Rep 2020 Mar 25;13(3). Epub 2020 Mar 25.

Department of General Medicine, Saga University Hospital, Saga, Japan.

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http://dx.doi.org/10.1136/bcr-2020-235168DOI Listing

Development of disease-modifying drugs for frontotemporal dementia spectrum disorders.

Nat Rev Neurol 2020 04 23;16(4):213-228. Epub 2020 Mar 23.

Department of Research and Development, Chiesi Farmaceutici, Parma, Italy.

Frontotemporal dementia (FTD) encompasses a spectrum of clinical syndromes characterized by progressive executive, behavioural and language dysfunction. The various FTD spectrum disorders are associated with brain accumulation of different proteins: tau, the transactive response DNA binding protein of 43 kDa (TDP43), or fused in sarcoma (FUS) protein, Ewing sarcoma protein and TATA-binding protein-associated factor 15 (TAF15) (collectively known as FET proteins). Approximately 60% of patients with FTD have autosomal dominant mutations in C9orf72, GRN or MAPT genes. Read More

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http://dx.doi.org/10.1038/s41582-020-0330-xDOI Listing
April 2020
15.358 Impact Factor

Maneuvering the Management of a Rare Case of Primary Undifferentiated Cardiac Sarcoma.

Am J Case Rep 2020 Mar 21;21:e918878. Epub 2020 Mar 21.

Department of Sarcoma Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.

BACKGROUND Primary cardiac tumors are rare and mostly benign. Cardiac sarcomas are the most common malignant neoplasms of the heart and harbor a dismal prognosis of 6 to 12 months. The diagnosis of cardiac sarcomas may be challenging. Read More

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http://dx.doi.org/10.12659/AJCR.918878DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7117855PMC

Circulating MicroRNAs in Plasma Decrease in Response to Sarcopenia in the Elderly.

Front Genet 2020 5;11:167. Epub 2020 Mar 5.

Department of Cardiology, HwaMei Hospital, University of Chinese Academy of Sciences, Ningbo, China.

sarcopenia has been defined as the aging-related disease with the declined mass, strength, and function of skeletal muscle, which is a major cause of morbidity and mortality in elders. Current diagnostic criteria of sarcopenia have not been agreed internationally, and the clinical diagnostic biomarkers for sarcopenia have not been identified. Circulating miRNAs (miRNAs, miRs) have recently been characterized as novel biomarkers for sarcopenia. Read More

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http://dx.doi.org/10.3389/fgene.2020.00167DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7066121PMC

Misdiagnosis of primary intimal sarcoma of the pulmonary artery as chronic pulmonary embolism: A case report.

Authors:
Ping Lu Bei-Bei Yin

World J Clin Cases 2020 Mar;8(5):986-994

Department of Oncology, The First Affiliated Hospital of Shandong First Medical University, Jinan 250014, Shandong Province, China.

Background: Primary intimal sarcoma of the pulmonary artery is a rare malignant tumor originating from the pulmonary artery, which has a low incidence rate and is easily misdiagnosed as pulmonary embolism. There is no standard protocol for the treatment of primary intimal sarcoma of the pulmonary artery.

Case Summary: This study reports a patient with primary intimal sarcoma of the pulmonary artery who was admitted to our hospital in 2017. Read More

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http://dx.doi.org/10.12998/wjcc.v8.i5.986DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7062609PMC

Efficacy and safety of anlotinib, a multikinase angiogenesis inhibitor, in combination with epirubicin in preclinical models of soft tissue sarcoma.

Cancer Med 2020 May 17;9(10):3344-3352. Epub 2020 Mar 17.

Department of Medical Oncology, Zhongshan Hospital, Fudan University, Shanghai, China.

Background: Anlotinib is a novel, orally administered, multitarget receptor tyrosine kinase inhibitor. It functions by inhibiting tumor angiogenesis and proliferative signaling pathways. In this study, we aimed to investigate the efficacy and safety of anlotinib plus epirubicin in a sarcoma patient-derived xenografts (PDX) model. Read More

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http://dx.doi.org/10.1002/cam4.2941DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7221313PMC

Effects of dexrazoxane on doxorubicin-related cardiotoxicity and second malignant neoplasms in children with osteosarcoma: a report from the Children's Oncology Group.

Cardiooncology 2019 28;5:15. Epub 2019 Oct 28.

6Department of Pediatrics, University at Buffalo, Oishei Children's Hospital, Roswell Park Comprehensive Cancer Center, Buffalo, NY USA.

Background: Dexrazoxane protects from lower-cumulative-dose doxorubicin cardiotoxicity, but the effect of dexrazoxane in children with sarcoma treated with higher-cumulative-dose doxorubicin is unknown.

Methods: We evaluated children with osteosarcoma (OS) on two Children's Oncology Group trials with higher dose doxorubicin (375-600 mg/m) preceded by dexrazoxane (10:1 dexrazoxane:doxorubicin dosing). They were evaluated after the minimum expected treatment time (METT), defined as 28 weeks. Read More

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http://dx.doi.org/10.1186/s40959-019-0050-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7048050PMC
October 2019

A superior vena cava to right pulmonary artery shunt for severe right ventricular outflow tract stenosis caused by an unresectable cardiac tumor.

J Cardiol Cases 2020 Mar 13;21(3):97-100. Epub 2019 Nov 13.

Department of Cardiac Surgery, The University of Tokyo, Tokyo, Japan.

We report the case of a 47-year-old man who was diagnosed with severe right ventricular outflow tract (RVOT) stenosis due to a space-occupying lesion; the diagnosis was made using computed tomography. He underwent mass reduction, pulmonary valve replacement, and RVOT reconstruction with a bovine pericardial patch. The pathological diagnosis was undifferentiated pleomorphic sarcoma originating from the myocardium. Read More

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http://dx.doi.org/10.1016/j.jccase.2019.10.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7054662PMC

Intimal sarcoma of the left atrium presenting with transient ischaemic attack - A case report and review of the literature.

J Cardiol Cases 2020 Mar 16;21(3):89-92. Epub 2019 Nov 16.

Black Country Pathology Services, New Cross Hospital, Wolverhampton, UK.

A 31-year-old female with a history of polycystic ovary syndrome and two recent miscarriages presented with symptoms of a transient ischemic attack. Echocardiography to assess for possible embolic source identified a 4.8 cm left atrial mass, presumed to be an atrial myxoma. Read More

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http://dx.doi.org/10.1016/j.jccase.2019.10.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7054658PMC

[Phyllodes tumor of the breast with heart and lung metastases: a case report].

Zhonghua Nei Ke Za Zhi 2020 Mar;59(3):229-231

Department of Radiology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing100730, China.

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http://dx.doi.org/10.3760/cma.j.issn.0578-1426.2020.03.013DOI Listing

Survival outcomes in patients with primary cardiac sarcoma in the United States.

J Thorac Cardiovasc Surg 2020 Jan 23. Epub 2020 Jan 23.

Division of Cardiac Surgery, Boston Medical Center, Boston University School of Medicine, Boston, Mass. Electronic address:

Objective: We aim to evaluate the survival outcomes of primary cardiac sarcoma in a US nationwide cancer database.

Methods: The Surveillance, Epidemiology, and End Results database was queried to identify patients with primary cardiac sarcoma from 1973 to 2015. Kaplan-Meier analysis and log-rank tests were performed to compare overall survival for subpopulations, stratified on year at diagnosis (dichotomized into 2 periods: 1973-2005 and 2006-2015), pathological types, whether patients were treated with surgery or not, and surgery and chemotherapy combinations. Read More

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http://dx.doi.org/10.1016/j.jtcvs.2019.12.109DOI Listing
January 2020
4.168 Impact Factor

Angiosarcoma Involving the Heart.

N Engl J Med 2020 Feb;382(9):855

University Hospital Zurich, Zurich, Switzerland

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http://dx.doi.org/10.1056/NEJMicm1910259DOI Listing
February 2020

Commentary: Cardiac sarcoma-Can we win this battle?

J Thorac Cardiovasc Surg 2020 Jan 31. Epub 2020 Jan 31.

Division of Cardiothoracic Surgery, University of Miami Miller School of Medicine, and the Miami Veterans Administration Medical Center, Miami, Fla. Electronic address:

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http://dx.doi.org/10.1016/j.jtcvs.2020.01.033DOI Listing
January 2020

Evaluation of the cost-effectiveness of dexrazoxane for the prevention of anthracycline-related cardiotoxicity in children with sarcoma and haematologic malignancies: a European perspective.

Cost Eff Resour Alloc 2020 10;18. Epub 2020 Feb 10.

Prism Ideas Ltd, Morston House, Beam Heath Way, Nantwich, CW5 6GD UK.

Background: Anthracycline-treated childhood cancer survivors are at higher risk of cardiotoxicity, especially with cumulative doses received above 250 mg/m. Dexrazoxane is the only option recommended for cardiotoxicity prevention in high-risk patients supported by randomised trials but its cost-effectiveness in paediatric cancer patients has not been established.

Methods: A cost-effectiveness model applicable to different national healthcare system perspectives, which simulates 10,000 patients with either sarcoma or haematologic malignancies, based upon baseline characteristics including gender, age at diagnosis, cumulative anthracycline dose and exposure to chest irradiation. Read More

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http://dx.doi.org/10.1186/s12962-020-0205-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7011276PMC
February 2020

Commentary: Cardiac sarcoma remains a formidable challenge.

J Thorac Cardiovasc Surg 2020 Jan 22. Epub 2020 Jan 22.

Division of Cardiac Surgery, Department of Surgery, Johns Hopkins University, Baltimore, Md. Electronic address:

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http://dx.doi.org/10.1016/j.jtcvs.2020.01.010DOI Listing
January 2020

Extraosseous Ewing Sarcoma Presenting with Inferior ST-Elevation Myocardial Infarction and Systemic Emboli due to Tumor Thrombus and Invasion of the Left Atrium.

Case Rep Orthop 2020 27;2020:3861927. Epub 2020 Jan 27.

Marshall University Department of Hematology and Oncology, 1400 Hal Greer Blvd Huntington, WV 25701, USA.

Extraosseous Ewing sarcoma is an uncommon entity in the adult population. Cardiac metastases or local invasion of a tumor into the heart is a known but also infrequent occurrence for most malignancies. We present a case of a patient with a history of extraosseous Ewing sarcoma who presented to the emergency room with chest pain and was found to have an inferior ST-elevation myocardial infarction and systemic emboli and was found to have recurrence of sarcoma invading the left atrium. Read More

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http://dx.doi.org/10.1155/2020/3861927DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7007952PMC
January 2020

Successful Surgical Treatment of a Giant Pulmonary Vein Ewing's Sarcoma Invading Left Atrium.

Arch Bronconeumol 2020 Feb 7. Epub 2020 Feb 7.

Department of Thoracic Surgery and Lung Transplantation, University Hospital Reina Sofía, Córdoba, Spain.

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http://dx.doi.org/10.1016/j.arbres.2019.12.031DOI Listing
February 2020

A comprehensive review on the diagnosis and management of intimal sarcoma of the pulmonary artery.

Crit Rev Oncol Hematol 2020 Mar 30;147:102889. Epub 2020 Jan 30.

French Sarcoma Group, Gustave Roussy Cancer Campus, Villejuif, France.

Only a few hundred cases of intimal sarcomas of pulmonary artery (ISPA) were reported on the literature. Diagnosis of this rare entity is a challenging dilemma with the need for a high expertise in the radiological and pathological identification of ISPA. Treatment strategies rely initially on an early aggressive surgery aiming for complete surgical resection with clear margins while no clear recommendations guiding the choice for additional drug therapy or radiotherapy exist. Read More

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http://dx.doi.org/10.1016/j.critrevonc.2020.102889DOI Listing
March 2020
4.027 Impact Factor

An NRAS mutation in primary malignant melanoma of the lung: a case report.

Diagn Pathol 2020 Feb 7;15(1):11. Epub 2020 Feb 7.

Department of Pathology, Yokohama City University Hospital, 3-9 Fukuura, Kanazawa-ku, Yokohama, 236-0004, Japan.

Background: Primary malignant melanoma of the lung (PML) is extremely rare. No precursor lesions of PML have been identified, and little is known about the genetic mutations associated with the disease. Typically, 15-20% of malignant melanomas possess NRAS gene mutations, but no cases of NRAS-mutated PML have been reported in the English literature. Read More

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http://dx.doi.org/10.1186/s13000-020-0928-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7006422PMC
February 2020

Occlusion of the pulmonary artery by a primary pulmonary artery sarcoma resulting in cardiac arrest: a case report.

JA Clin Rep 2019 Feb 28;5(1):15. Epub 2019 Feb 28.

Department of Anesthesiology, Division of Clinical Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan.

Background: Primary pulmonary arterial sarcoma (PPAS) is a rare condition. Although resection is recommended to improve prognosis, optimal anesthesia management for these cases remains unclear.

Case Presentation: A 62-year-old woman with a diagnosis of left pulmonary PPAS underwent surgical tumor resection and left lung pneumonectomy. Read More

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http://dx.doi.org/10.1186/s40981-019-0235-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6967184PMC
February 2019

Complications after thigh sarcoma resection.

J Surg Oncol 2020 May 4;121(6):945-951. Epub 2020 Feb 4.

Division of Plastic Surgery, Mayo Clinic, Rochester, Minnesota.

Background And Objectives: Standard treatment for extremity sarcoma is limb-sparing surgery often with radiation, but complications occur frequently. We sought to determine factors predictive of wound complications after thigh sarcoma resection and reconstruction while analyzing trends over time.

Methods: We reviewed all thigh defects requiring plastic surgeon reconstruction following sarcoma resection at our institution from 1997 to 2014. Read More

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http://dx.doi.org/10.1002/jso.25830DOI Listing

Pulmonary intimal sarcoma involving the pulmonary valve and right ventricular outflow tract: A case report and literature review.

Medicine (Baltimore) 2020 Jan;99(3):e18813

Department of Ultrasonography, Second Hospital of Jilin University.

Introduction: Pulmonary artery intimal sarcoma (PAIS) is a rare and highly aggressive tumor, and approximately 80% of pulmonary cases occur in the pulmonary trunk. We report herein a case of retrograde extension of the sarcoma to the pulmonary valve and right ventricle, which is an uncommon manifestation of this lethal tumor.

Patient Concerns: A 41-year-old woman was initially diagnosed with pulmonary thromboembolism (PTE) and transferred to our hospital. Read More

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http://dx.doi.org/10.1097/MD.0000000000018813DOI Listing
January 2020

Endovascular brachytherapy for extensive right-heart and pulmonary artery sarcoma - a case report.

J Contemp Brachytherapy 2019 Dec 25;11(6):579-583. Epub 2019 Dec 25.

Department of Cardiothoracic Surgery, Hadassah Hebrew University Medical Center, Jerusalem, Israel.

Purpose: Primary sarcoma of the heart is a rare but devastating tumor. Median survival with conventional treatment is 8-12 months. When resection is not feasible, patients often succumb to heart failure secondary to obstruction of blood flow, valve dysfunction, chamber compression or conduction abnormalities. Read More

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http://dx.doi.org/10.5114/jcb.2019.91226DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6964349PMC
December 2019

Malignant primary tumor in left atrium with mitral valve invasion, pulmonary veins and cerebral metastasis. A case report.

Cir Cir 2020 ;88(1):91-94

Servicio de Cirugía Oncológica, Unidad Médica de Alta Especialidad. Hospital de Especialidades, Centro Médico Nacional de Occidente, Instituto Mexicano del Seguro Social, Guadalajara, Jalisco, México.

Introduction: The incidence of cardiac primary tumors is estimated to be 0.0017-0.28%, of which 25% are malignant, occupying mainly right cavities. Read More

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http://dx.doi.org/10.24875/CIRU.19000909DOI Listing
January 2020

Simultaneous Left Ventricular Volume and Strain Changes During Chemotherapy Associate With 2-Year Postchemotherapy Measures of Left Ventricular Ejection Fraction.

J Am Heart Assoc 2020 Jan 21;9(2):e015400. Epub 2020 Jan 21.

Section on Cardiovascular Medicine and Pathology Section on Comparative Medicine Department of Internal Medicine Wake Forest School of Medicine Winston-Salem NC.

Background Although changes in left ventricular end-systolic volume (LVESV), left ventricular end-diastolic volume, and global circumferential strain occur during cancer treatment, the relationship of these changes to the 2-year post-cancer-treatment measures of left ventricular ejection fraction (LVEF) are unknown. Methods and Results In a prospective, continuously recruited cohort of 95 patients scheduled to receive potentially cardiotoxic chemotherapy for breast cancer, lymphoma, or soft tissue sarcoma, measures of left ventricular end-diastolic volume, LVESV, global circumferential strain, and LVEF were acquired via cardiac magnetic resonance imaging before and then 3 and 24 months after initiating treatment by individuals blinded to all patient identifiers. Participants had an average age of 54±15 years; 68% were women, and 82% were of white race. Read More

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http://dx.doi.org/10.1161/JAHA.119.015400DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7033821PMC
January 2020

Oncogenic Viral Infections Among Iranian Hemodialysis Patients: A Systematic Review.

Int J Prev Med 2019 10;10:216. Epub 2019 Dec 10.

Substance Abuse and Dependence Research Center, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran.

Introduction: Chronic hemodialysis is a lifesaving procedure for end-stage renal failure patients who may lead to the transmission of oncogenic viral infections discussed as a major cause of liver disease and a potential cause of substantial morbidity and mortality. In this regard, the hepatitis B virus (HBV) and hepatitis C virus (HCV) are the most common infections that studied recently. This study aimed to review systematically all available documents on the prevalence of hepatitis D virus (HED), hepatitis E virus (HEV), hepatitis G virus (HGV), human T-lymphotropic virus (HTLV), human immunodeficiency virus (HIV), and Kaposi's sarcoma-associated herpes virus (KSHV) in Iranian hemodialysis patients. Read More

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http://dx.doi.org/10.4103/ijpvm.IJPVM_458_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6941381PMC
December 2019