1,654,982 results match your criteria Cardiac Neoplasms Primary
J Vet Sci 2018 Dec 4. Epub 2018 Dec 4.
Department of Veterinary Internal Medicine, College of Veterinary Medicine, Konkuk University, Seoul, 05030, Korea.
Genome-wide association study (GWAS) is a powerful tool for identifying the genetic causes of various diseases. This study conducted to identify genomic variation in Maltese dog genomes associated with degenerative mitral valve disease (DMVD) development and evaluate the association of each biological condition with DMVD in Maltese dogs. DNA was extracted from blood samples obtained from 48 Maltese dogs (32 with DMVD and 16 controls). Read More
Thorac Cardiovasc Surg 2018 11 12;66(8):607. Epub 2018 Dec 12.
Department of Cardiac, Thoracic and Vascular Surgery, Universitaetsmedizin Mainz, Mainz, Germany.
Nucleic Acids Res 2018 Dec 12. Epub 2018 Dec 12.
Division of Medical Genetics and Genomics, The Children's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310058, China.
The tissue specificity of mitochondrial tRNA mutations remains largely elusive. In this study, we demonstrated the deleterious effects of tRNAThr 15927G>A mutation that contributed to pathogenesis of coronary artery disease. The m. Read More
J Am Med Inform Assoc 2018 Dec;25(12):1634-1642
Emory University School of Medicine, Atlanta, GA, USA.
Background: The prevalence of moderate or complex (moderate-complex) congenital heart defects (CHDs) among adults is increasing due to improved survival, but many patients experience lapses in specialty care or their CHDs are undocumented in the medical system. There is, to date, no efficient approach to identify this population.
Objective: To develop and assess the performance of a risk score to identify adults aged 20-60 years with undocumented specific moderate-complex CHDs from electronic health records (EHR). Read More
Eur Heart J Cardiovasc Imaging 2018 Dec 11. Epub 2018 Dec 11.
Department of Cardiovascular Medicine, Chonnam National University Hospital, 42 Jebong-ro, Dong-gu, Gwangju, Korea.
Aims: There is a paucity of data regarding the changes of cardiac geometry in highly trained international and multiracial university athletes. We aimed to investigate the incidence of structural cardiac abnormalities and changes of cardiac geometry in highly trained university athletes.
Methods And Results: Comprehensive echocardiographic studies were performed in 1185 university athletes through the Check-up Your Heart Program during the 2015 Gwangju Summer Universiade. Read More
Eur J Cardiothorac Surg 2018 Dec 11. Epub 2018 Dec 11.
Department of Cardio-Thoracic Surgery, Maastricht University Medical Centre, Maastricht, Netherlands.
Surgical aortic valve replacement (SAVR) is highly effective and can be achieved with relatively low risk in patients with severe aortic stenosis. Bioprostheses have been used most frequently during the past 60 years. However, the function of biological valves usually declines after 10-15 years from implant when structural valve degeneration occurs often mandating a reoperation once valve dysfunction becomes haemodynamically significant. Read More
Eur Heart J Cardiovasc Imaging 2018 Dec 11. Epub 2018 Dec 11.
Department of Cardiology, Herlev & Gentofte Hospital, University of Copenhagen, Denmark.
Aims: Left atrial (LA) enlargement predicts cardiovascular risk. The prognostic value of left atrial peak reservoir strain (LA RS) by two-dimensional speckle tracking in the general population is currently unknown. This study sought to determine the prognostic value of LA RS in the general population. Read More
Eur Heart J 2018 Dec 11. Epub 2018 Dec 11.
INSERM U1148, Laboratory for Vascular Translational Science (LVTS), DHU FIRE, University Paris Diderot, Sorbonne Paris Cité, 46 rue Henri Huchard, Paris, France.
Aims: Inflammatory mediators, including blood cells and their products, contribute critically to atherogenesis, but the igniting triggers of inflammation remain elusive. Atherosclerosis develops at sites of flow perturbation, where the enhanced haemodynamic stress could initiate the atherogenic inflammatory process due to the occurrence of mechanic injury. We investigated the role of haemodynamic stress-induced breaches, allowing the entry of blood cells in the arterial intima, in triggering inflammation-driven atherogenesis. Read More
Eur J Cardiothorac Surg 2018 Dec 11. Epub 2018 Dec 11.
Department of Anaesthesia, Intensive Care Medicine and Pain Medicine, Division of Cardiac Thoracic Vascular Anaesthesia and Intensive Care Medicine, Medical University of Vienna, Vienna, Austria.
Exposure to heparin and protamine during cardiac surgery on cardiopulmonary bypass (CPB) may trigger heparin-induced thrombocytopaenia and/or protamine-induced thrombocytopaenia. Further surgery on CPB with heparin and protamine in the presence of these antibodies implies increased thromboembolic risk. We present the successful application of extracorporeal immunoadsorption to deplete antibodies causing heparin-induced and protamine-induced thrombocytopaenia preoperatively. Read More
J Natl Cancer Inst 2018 Dec 12. Epub 2018 Dec 12.
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD.
Background: Genome-wide association studies (GWAS) identify associations of individual single-nucleotide polymorphisms (SNPs) with cancer risk but usually only explain a fraction of the inherited variability. Pathway analysis of genetic variants is a powerful tool to identify networks of susceptibility genes.
Methods: We conducted a large agnostic pathway-based meta-analysis of GWAS data using the summary-based adaptive rank truncated product method to identify gene sets and pathways associated with pancreatic ductal adenocarcinoma (PDAC) in 9040 cases and 12 496 controls. Read More
Interact Cardiovasc Thorac Surg 2018 Dec 11. Epub 2018 Dec 11.
Department of Cardiothoracic Surgery, Hunan Children's Hospital, Changsha, China.
Objectives: The aim of this study is to describe an effective surgical strategy for the treatment of children with pectus excavatum (PE) and concurrent congenital heart defect (CHD).
Methods: We retrospectively reviewed the medical records of all children (n = 16) who underwent simultaneous repair of PE with concurrent CHD at the Hunan Children's Hospital from July 2007 to December 2017. Among them, 7 patients had a simple atrial septal defect (ASD); 4 patients had a simple ventricular septal defect (VSD); 3 patients had both VSD and ASD; 1 patient had VSD, ASD and patent ductus arteriosus; and 1 patient had VSD complicated by pulmonary hypertension. Read More
Public Health Genomics 2018 Dec 12:1-14. Epub 2018 Dec 12.
Division of Human Genetics, Department of Internal Medicine, The Ohio State University, Columbus, Ohio, USA.
Background: Family health history tools have the ability to improve health outcomes and promote patient-provider communication, but some research suggests their effectiveness is limited. Tool design features may heavily influence users' perceptions of the tools.
Aims: This study provides a summative evaluation of the Family HealthLink tool, which assesses cancer and coronary heart disease risk based on personal and family health history, to better understand how tool design and message content impact user perceptions. Read More
J Crit Care 2018 Nov 30;50:144-154. Epub 2018 Nov 30.
Meridian HealthComms, Plumley Moor Road, Plumley, UK. Electronic address:
Purpose: Guidelines recommend crystalloids for fluid resuscitation in sepsis/shock and switching to albumin in cases where crystalloids are insufficient. We evaluated hemodynamic response to crystalloids/colloids in critically ill adults.
Materials And Methods: The primary research question was: "Are crystalloids sufficient for volume replacement in severe indications (intensive care unit [ICU]/critical illness)?" Randomized, controlled trials (RCTs) were identified using PubMed and EMBASE, and screened against predefined inclusion/exclusion criteria. Read More
J Crit Care 2018 Dec 5;50:138-143. Epub 2018 Dec 5.
Department of Critical Care Medicine (707), Radboud university medical center, PO Box 9101, 6500 HB Nijmegen, the Netherlands.
The administration of β-blockers in patients with sepsis is a trending topic in intensive care medicine since the landmark study by Morelli and colleagues, showing a striking decrease in 28-day mortality compared to standard care. While the available evidence suggests that the use of β-blockers in septic shock is safe, the effects on hemodynamics are controversial. In this paper, we review the effect of β-blockade in septic shock on hemodynamics from animal models to critically ill patients. Read More
Stem Cell Reports 2018 Dec;11(6):1365-1377
Global Safety Pharmacology, Non-Clinical Safety, Janssen Research & Development, A Division of Janssen Pharmaceutica NV, Turnhoutseweg 30, 2340 Beerse, Belgium.
Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) have emerged as a promising cardiac safety platform, demonstrated by numerous validation studies using drugs with known cardiac adverse effects in humans. However, the challenge remains to implement hiPSC-CMs into cardiac de-risking of new chemical entities (NCEs) during preclinical drug development. Here, we used the calcium transient screening assay in hiPSC-CMs to develop a hazard score system for cardiac electrical liabilities. Read More
Stem Cell Reports 2018 Dec;11(6):1306-1311
Department of Anatomy and Embryology, Leiden University Medical Centre, PO Box 9600, 2300 RC Leiden, the Netherlands. Electronic address:
Cardiovascular disease is still a major cause of ill-health and mortality, heart failure and arrhythmia being among the causes of sudden cardiac death. There are few drugs available for treatment or prevention and it remains difficult to predict who will develop these conditions, even when disease-causing mutations or associated gene variants are identified in individuals or families. This is in part because widely used rodent models may not fully capture the physiology of the human heart. Read More
Cell Rep 2018 Dec;25(11):2955-2962.e3
Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN 55455, USA. Electronic address:
Double homeobox (DUX) transcription factors are unique to eutherian mammals. DUX4 regulates expression of repetitive elements during early embryogenesis, but misexpression of DUX4 causes facioscapulohumeral muscular dystrophy (FSHD) and translocations overexpressing the DUX4 double homeodomain cause B cell leukemia. Here, we report the crystal structure of the tandem homeodomains of DUX4 bound to DNA. Read More
Korean J Intern Med 2018 Dec 13. Epub 2018 Dec 13.
Lung Research Institute of Hallym University College of Medicine, Chuncheon, Korea.
Background/aims: Inhaled corticosteroids (ICS) are a treatment of choice for eosinophilic airway diseases, but their efficacy for other causes of chronic cough is controversial.
Methods: We conducted a prospective observational study to determine the ICS efficacy and clinical predictors of response to ICS in patients with upper airway cough syndrome (UACS) or unexplained chronic cough (UCC). Sixty-eight patients with UACS and 33 patients with UCC (duration of cough ≥ 8 weeks) were treated with ICS: 250 µg of fluticasone propionate or 400 µg of budesonide twice a day at physician's discretion. Read More
Res Gerontol Nurs 2018 Dec 12:1-10. Epub 2018 Dec 12.
Heart failure (HF) remains the most common diagnosis of hospital admission among U.S. adults. Read More
PLoS One 2018 12;13(12):e0209081. Epub 2018 Dec 12.
Department of Food and Dietetics, Hiroshima Bunka Gakuen Two-Year College, 3-5-1 Nagatsukanishi, Asaminami-ku, Hiroshima, Japan.
Background: Many studies have identified the risk of polypharmacy, but physiological evidence and methods of evaluation in these studies were poor. The relationship between polypharmacy and heart rate variability in older adults remains unclear. We investigated the relationship between polypharmacy in older adults, including atomic bomb survivors, and heart rate variability. Read More
PLoS One 2018 12;13(12):e0208806. Epub 2018 Dec 12.
Department of Research, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran.
Aims: Recently, the clinical importance of total antioxidant capacity (TAC) and its protective role against several chronic diseases like cardiovascular disease, osteoporosis and several types of cancers has been reported. However, its association with cardio-metabolic risk factors among patients candidate for coronary artery bypass graft surgery (CABG) has not been evaluated yet. CABG is associated with increased oxidative stress and free radicals; so, the current study was aimed to evaluate the potential association of TAC with cardiovascular risk factors among patients candidate for CABG. Read More
PLoS One 2018 12;13(12):e0208796. Epub 2018 Dec 12.
Duke Clinical Research Institute, Duke University School of Medicine, Durham, North Carolina, United States of America.
Background: The number of patients with diabetes is increasing particularly in Asia-Pacific region. Many of them are treated with antidiabetics. As the basis of the studies on the benefit and harm of antidiabetic drugs in the region, the information on patterns of market penetration of new classes of antidiabetic medications is important in providing context for subsequent research and analyzing and interpreting results. Read More
PLoS One 2018 12;13(12):e0207194. Epub 2018 Dec 12.
Department of Radiology, NewYork-Presbyterian Hospital and the Weill Cornell Medical College, New York, New York, United States of America.
Background: The extent to which the presence and extent of subclinical atherosclerosis by coronary computed tomography angiography influences a potential mortality benefit of statin is unknown. We evaluated the relationship between statin therapy, mortality, and subclinical atherosclerosis.
Methods: In the CONFIRM study, patients with normal or non-obstructive plaque (<50% diameter stenosis) for whom data on baseline statin use was available were included. Read More
PLoS One 2018 12;13(12):e0203514. Epub 2018 Dec 12.
Division of Cardiology, Institute for Cardiology and Cardiac Surgery, NewYork-Presbyterian Brooklyn Methodist Hospital, Brooklyn, New York, United States of America.
Background/objectives: Previous studies have demonstrated that in acute coronary syndrome (ACS), plaque destabilization and vessel inflammation, represented by vessel edema, often occur simultaneously in multiple coronaries, as well as extend to the cerebrovascular system. Our aim was to determine whether the inflammatory vascular processes occurring within the coronaries during ACS extend simultaneously to the descending aorta.
Methods: We prospectively enrolled 111 patients (56 ACS patients and 55 non-ACS patients with known coronary artery disease) to undergo cardiac magnetic resonance of the thoracic aortic wall at presentation and at three-month follow-up. Read More
PLoS One 2018 12;13(12):e0207269. Epub 2018 Dec 12.
Cardiology, Military Hospital State Health Centre, Budapest, Hungary.
Aims: Left ventricular ejection fraction (LVEF) is the most frequently used parameter in the assessment of heart failure (HF). Cardiac index (CI) is considered a potential alternative to LVEF despite limited evidence. We aimed to assess and compare the predictive accuracy of LVEF and echocardiographically-assessed CI in HF patients. Read More
Rev Gastroenterol Peru 2018 Jul-Sep;38(3):285-288
Facultad de Medicina, Universidad Peruana Cayetano Heredia. Lima, Perú.
Ischemic Hepatitis is an uncommon entity in daily clinical practice with a prevalence of 0.16 to 0.5% among patients admitted to a critical care unit, associated with an approximate 60% mortality rate. Read More
Otol Neurotol 2019 Jan;40(1):16-21
World Hearing Center, Institute of Physiology and Pathology of Hearing, Warsaw/Kajetany.
Objective: The aim of the study was to assess the relationship between psychoacoustic matches of tinnitus loudness and tinnitus loudness measured with a visual analogue scale (VAS) in patients with normal hearing and patients with hearing loss.
Study Design: Cross-sectional study.
Patients: A clinical group of 140 adult patients (46. Read More
J Cardiovasc Pharmacol 2018 Dec 10. Epub 2018 Dec 10.
Department of Cardiology, The Second Hospital of Shandong University, Jinan, China.
Atorvastatin is a lipid-regulating drug that is commonly used in clinical practice and can stabilize plaques. Increasing evidence shows that statins have anti-heart failure effects, but their specific mechanism is not clear. The purpose of this study was to investigate the cardioprotective effects of atorvastatin on heart failure in rats and its mechanism. Read More
J Cardiovasc Pharmacol 2018 Dec 10. Epub 2018 Dec 10.
Servicio de Cardiología. Hospital Universitario Gregorio Marañón. CIBERCV. Madrid, Spain.
Sacubitril/valsartan (SV) is a new therapy in heart failure with reduced ejection fraction. Our aim was to determine the efficacy and safety of this drug daily clinical practice.We performed a multicenter registry in 10 hospitals. Read More
J Cardiovasc Pharmacol 2018 Dec 10. Epub 2018 Dec 10.
Hypertension & Vascular Research, Cardiovascular Sciences Center, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157.
Hypertensive transgenic (mRen2)27 rats exhibit impaired baroreflex sensitivity (BRS) for control of heart rate (HR). Intracerebroventricular (ICV) infusion of Ang-(1-7) improves indices of vagal BRS independent of lowering mean arterial pressure (MAP), while AT1 receptor blockade normalizes MAP and indices of sympathetic tone without correcting the vagal BRS. Scavenging cellular reactive oxygen species (ROS) with tempol in brain fails to correct either hypertension or sympathovagal balance in these animals, despite reports that mitochondrial ROS contributes to Ang II-infusion hypertension. Read More
J Cardiovasc Pharmacol 2018 Dec 10. Epub 2018 Dec 10.
University of Alberta, Edmonton, Canada.
Little is known about the dosing and tolerability of sacubitril/valsartan (LCZ696; Entresto™, Quebec, Canada) in a non-clinical trial population. This study was conducted to evaluate the use and tolerability of sacubitril/valsartan in patients followed at a multidisciplinary heart failure clinic. We performed a retrospective chart review of 126 patients with heart failure, initiated on sacubitril/valsartan, and seen at a specialty heart failure clinic between August 1, 2015 and August 1, 2017. Read More
J Hypertens 2018 Dec 11. Epub 2018 Dec 11.
Boehringer Ingelheim International GmbH, Ingelheim.
Objective: Concomitant treatment with angiotensin-converting enzyme (ACE) inhibitors and dipeptidyl peptidase-4 (DPP-4) inhibitors is increasingly common. Pharmacological studies have suggested a potential adverse drug interaction between ACE inhibitors and DPP-4 inhibitors resulting in unfavorable hemodynamic changes; very few studies have examined such an interaction between angiotensin II receptor blockers (ARBs) and DPP-4 inhibitors. We investigated blood pressure (BP) and heart rate (HR) during treatment with the DPP-4 inhibitor linagliptin in individuals receiving either ACE inhibitors or ARBs in the MARLINA-T2D trial. Read More
J Cardiovasc Med (Hagerstown) 2018 Dec 3. Epub 2018 Dec 3.
Division of Cardiology, Duke University Medical Center, Durham.
J Cardiovasc Med (Hagerstown) 2018 Dec 11. Epub 2018 Dec 11.
Department of Medicine, Bluhm Cardiovascular Institute, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
: Patients with end-stage renal disease (ESRD) undergoing evaluation for kidney and/or pancreas transplantation represent a population with unique cardiovascular (CV) profiles and unique therapeutic needs. Coronary artery disease (CAD) is common in patients with ESRD, mediated by both the overrepresentation and higher prognostic value of traditional CV risk factors amongst this population, as well as altered cardiovascular responses to failing renal function, likely mediated by dysregulation of the renin-angiotensin-aldosterone system (RAAS) and abnormal calcium and phosphate metabolism. Within the ESRD population, obstructive CAD correlates highly with adverse coronary events, including during the peri-transplant period, and successful revascularization may attenuate some of that increased risk. Read More
J Cardiovasc Med (Hagerstown) 2018 Dec 11. Epub 2018 Dec 11.
Cardiovascular Diseases Unit, Department of Internal Medicine, Le Scotte Hospital, University of Siena.
Background: Diabetes is a common disease in heart failure and its prevalence ranges from 10 to 30%. ST-2 is a novel biomarker of myocardial fibrosis and remodelling in heart failure and may be involved in the inflammatory process of diabetes mellitus. In this study, we sought: to evaluate levels of ST-2 and B-type natriuretic peptide (BNP) in groups with acute heart failure with and without diabetes; to analyse the prognostic impact of ST-2 over a 6-month follow-up period. Read More
Eur J Anaesthesiol 2018 Dec 11. Epub 2018 Dec 11.
From the Department of Anaesthesia, Burn, and Critical Care, Saint-Louis Lariboisière University Hospital (RB, FD, MR, JS, AM, BGC), Department of Anaesthesia and Critical Care, European Hospital Georges-Pompidou, APHP (AN, DD, RP), Paris Diderot University, Sorbonne Paris Cité (AM, BGC), Inserm U942 (AM), Paris Descartes University, Sorbonne Paris Cité (RP), Inserm U1153 (RP) and Inserm U1160, Paris, France (BGC).
Background: The ability of the pressure recording analytical method (PRAM) in tracking change in cardiac output (ΔCO) after a fluid challenge in ICU needs to be evaluated with the most contemporary comparison methods recommended by experts.
Objective: Our objective was to report the trending ability of PRAM in tracking ΔCO after a fluid challenge in ICU and to compare this with oesophageal Doppler monitoring (ODM).
Design: Prospective, observational study. Read More
Pain 2018 Oct 17. Epub 2018 Oct 17.
Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, United States.
Although self-report pain ratings are the gold standard in clinical pain assessment, they are inherently subjective in nature and significantly influenced by multidimensional contextual variables. Although objective biomarkers for pain could substantially aid pain diagnosis and development of novel therapies, reliable markers for clinical pain have been elusive. In this study, individualized physical maneuvers were used to exacerbate clinical pain in patients with chronic low back pain (N = 53), thereby experimentally producing lower and higher pain states. Read More
Anesth Analg 2018 Dec 11. Epub 2018 Dec 11.
Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland†Division of Medical Psychology, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Background: Frailty is a geriatric syndrome thought to identify the most vulnerable older adults, and morbidity and mortality has been reported to be higher for frail patients after cardiac surgery compared to nonfrail patients. However, the cognitive consequences of frailty after cardiac surgery have not been well described. In this study, we examined the hypothesis that baseline frailty would be associated with postoperative delirium and cognitive change at 1 and 12 months after cardiac surgery. Read More
Anticancer Drugs 2019 Jan;30(1):110-115
Department of Oncology, Cambridge University Hospitals NHS Foundation Trust, Addenbrooke's Hospital, Cambridge Biomedical Campus, Cambridge, UK.
Trabectedin is used routinely in the palliative management of patients with advanced soft tissue sarcoma. It is not generally considered to be cardiotoxic, and there is no specific caution for its use in patients with a history of cardiac disease or risk factors. Here, we report six cases from a single academic centre where life-threatening cardiotoxicity occurred acutely during treatment with trabectedin. Read More
Innovations (Phila) 2018 Dec 5. Epub 2018 Dec 5.
From the Divisions of Cardiac Surgery and.
Objective: Conversion to sternotomy is a primary bailout method for robotically assisted coronary artery bypass grafting procedures. The aims of this study were to identify the primary reasons for conversion from robotically assisted coronary artery bypass grafting to sternotomy and to evaluate the in-hospital outcomes in such patients.
Methods: Prospectively collected data from February 2004 to April 2017 were reviewed for 72 patients (56 men; mean age = 63. Read More
Innovations (Phila) 2018 Dec 5. Epub 2018 Dec 5.
LSI SOLUTIONS, Victor, NY USA.
Traditionally, pacing leads are placed transvenously, although smaller pediatric patients who require permanent pacemakers may benefit from delaying tranvenous lead placement until they are larger. Alternative, minimally invasive atrioventricular pacing options have not previously existed for this patient population, leaving many of these children with large sternotomies or thoracotomies. Using three port sites and an adjustable shaft dual-needle suturing device, we placed a steroid-eluting, sew-on epicardial lead on the right atrium of a 9-year-old patient. Read More
Innovations (Phila) 2018 Dec 5. Epub 2018 Dec 5.
From the Cardiac Surgery Department, Parma University Hospital, Parma, Italy.
Different case series have been published demonstrating the feasibility of endovascular repair of the ascending aorta in selected patients deemed unfit for open surgery. However, the use of commercially available stent graft in the ascending aorta remains off-label, and their excessive length often prevents their deployment in the ascending aorta. Here we report a case of successful primary endovascular repair of the ascending aorta using a physician modified off-the-shelf device. Read More
Plant Dis 2018 Dec 12:PDIS01180147RE. Epub 2018 Dec 12.
Department of Plant Pathology and Weed Research, Agricultural Research Organization (ARO), the Volcani Center, Rishon Le'Zion, 7528809 Israel.
Heart rot, caused by Alternaria alternata, is a major pomegranate disease that impacts production worldwide; most fruits in orchards are colonized by A. alternata but, nevertheless, symptoms are apparent on only a small proportion of the colonized fruits. During the years of our previous research it was noticed that within individual orchards, the incidence of pomegranate fruits exhibiting heart rot symptoms was related to the visual appearance of the trees: trees that appeared visually frail bore more diseased fruits than robust trees. Read More
Mol Biol Cell 2018 Dec 12:mbcE18100615. Epub 2018 Dec 12.
Laboratory of Cellular and Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 37 Convent Dr. Rm 2050B, Bethesda, MD, 20892 USA.
Lumen establishment and maintenance are fundamental for tubular organs physiological functions. Most of the studies investigating the mechanisms regulating this process have been carried out in cell cultures or in smaller organisms, whereas little has been done in mammalian model systems in vivo. Here we used the salivary glands of live mice to examine the role of the small GTPase Cdc42 in the regulation of the homeostasis of the intercellular canaliculi, a specialized apical domain of the acinar cells, where protein and fluid secretion occur. Read More
Am J Respir Crit Care Med 2018 Dec 12. Epub 2018 Dec 12.
Imperial College London & Royal Brompton Hospital, London, United Kingdom of Great Britain and Northern Ireland.
JAMA Cardiol 2018 Dec 12. Epub 2018 Dec 12.
Stanford Center for Clinical Research, Department of Medicine, Stanford University School of Medicine, Stanford, California.
Importance: Patients with peripheral artery disease (PAD) are at high risk for myocardial infarction (MI).
Objective: To characterize the incidence and types of MI in a PAD population, identify factors associated with MI, and determine the association of MI with cardiovascular mortality and acute limb ischemia.
Design, Setting, And Participants: The Study Comparing Cardiovascular Effects of Ticagrelor and Clopidogrel in Patients With Peripheral Artery Disease (EUCLID) was a double-blind randomized clinical trial conducted at 811 sites in 28 countries that randomized 13 885 patients with symptomatic PAD to monotherapy with ticagrelor or clopidogrel. Read More
JAMA Surg 2018 Dec 12. Epub 2018 Dec 12.
Department of Medicine, VA Boston Healthcare System, Boston, Massachusetts.
Importance: Limited data suggest that screening for asymptomatic bacteriuria (ASB) prior to nonurologic procedures is not useful. However, high-quality evidence to support consensus recommendations and influence clinical practice is lacking.
Objective: To characterize the association between detection and treatment of preoperative ASB and postoperative outcomes. Read More
JAMA Cardiol 2018 Dec 12. Epub 2018 Dec 12.
Thrombolysis in Myocardial Infarction (TIMI) Study Group, Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
Importance: Little is known about the heterogeneity in low-density lipoprotein cholesterol levels (LDL-C) lowering with proprotein convertase subtilisin kexin 9 (PCSK9) inhibitor medications.
Objective: To evaluate the interindividual variability in LDL-C reduction with the PCSK9 inhibitor drug evolocumab.
Design, Setting, And Participants: We examined the percentage change in LDL-C levels from baseline in the Further Cardiovascular Outcomes Research With PCSK9 Inhibition in Subjects With Elevated Risk (FOURIER) trial, a placebo-controlled randomized clinical trial of the PCSK9 inhibitor evolocumab in patients with stable atherosclerotic cardiovascular disease who were taking statin medications. Read More
J Strength Cond Res 2018 Nov;32(11):3177-3185
School of Health, Medical, and Applied Sciences, Central Queensland University, Rockhampton, Australia.
Berkelmans, DM, Dalbo, VJ, Fox, JL, Stanton, R, Kean, CO, Giamarelos, KE, Teramoto, M, and Scanlan, AT. Influence of different methods to determine maximum heart rate on training load outcomes in basketball players. J Strength Cond Res 32(11): 3177-3185, 2018-The summated-heart-rate-zones (SHRZ) approach uses heart rate (HR) responses relative to maximum HR (HRmax) to calculate the internal training load (TL). Read More
Elife 2018 Dec 12;7. Epub 2018 Dec 12.
Department of Cell and Developmental Biology, Vanderbilt University, Nashville, United States.
The sarcomere is the contractile unit within cardiomyocytes driving heart muscle contraction. We sought to test the mechanisms regulating actin and myosin filament assembly during sarcomere formation. Therefore, we developed an assay using human cardiomyocytes to monitor sarcomere assembly. Read More