8,629 results match your criteria Cardiac Neoplasms Primary


Effect of hydroxychloroquine on COVID-19 prevention in cancer patients undergoing treatment: a structured summary of a study protocol for a randomised controlled trial.

Trials 2020 Jun 26;21(1):575. Epub 2020 Jun 26.

Division of Hematology and Oncology, Department of Internal Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

Objectives: In this study, we investigate the effect of hydroxychloroquine on the prevention of Novel Coronavirus Disease (COVID-19) in cancer patients being treated.

Trial Design: This is a multi-centre, two-arm, parallel-group, triple-blind, phase 2-3 randomised controlled trial.

Participants: All patients over the age of 15 from 5 types of cancer are included in the study. Read More

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http://dx.doi.org/10.1186/s13063-020-04485-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7316578PMC

[The clinical characteristics and surgical management of ciliated muconodular papillary tumor].

Zhonghua Zhong Liu Za Zhi 2020 Jun;42(6):491-494

Department of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.

To investigate the clinical characteristics and surgical management based on the clinical manifestation, pathological feature and the medical imaging finding of ciliated muconodular papillary tumor (CMPT). The data of clinical manifestation, pathological feature and the medical imaging finding of 15 patients with CMPT who received surgical treatment from January 2017 to April 2019 were collected and retrospectively analyzed. CMPT generally occurred in the elderly people. Read More

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http://dx.doi.org/10.3760/cma.j.cn112152-20190829-00555DOI Listing

[Resection of recurrent hemangioma of the anterior mediastinum with aortic arch replacement and simultaneous resection of left atrial myxoma].

Khirurgiia (Mosk) 2020 (6):114-117

Sechenov First Moscow State Medical University of the Ministry of Health of Russia (Sechenov University), Moscow, Russia.

Patients with anterior mediastinum tumors fall into a difficult category due to high risk of invasion of vital structures and complexity of surgical correction. We report resection of recurrent hemangioma of anterior mediastinum with aortic arch replacement and simultaneous resection of left atrial myxoma in a 35-year-old woman. Successful treatment of these patients correlates with aggressive surgical approach followed by total resection of tumor and all affected vessels and other tissues. Read More

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http://dx.doi.org/10.17116/hirurgia2020061114DOI Listing

Cardiac Autotransplantation with Concurrent Pneumonectomy for Complete Resection of Primary Cardiac Intimal Sarcoma.

Korean J Thorac Cardiovasc Surg 2020 Jun;53(3):140-143

Department of Thoracic and Cardiovascular Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

Primary cardiac sarcoma is rare, and intimal sarcoma is an extremely rare and highly lethal disease. We report a case of a 62-year-old woman who was incidentally diagnosed with a primary cardiac sarcoma originating from the left atrial appendage and extending to the left superior pulmonary vein. The location of the tumor was very complicated, posing a major challenge for complete resection. Read More

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http://dx.doi.org/10.5090/kjtcs.2020.53.3.140DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7287220PMC

Primary Biatrial Cardiac Rhabdomyosarcoma.

Braz J Cardiovasc Surg 2020 Jun 1;35(3):399-401. Epub 2020 Jun 1.

Yamagata University Faculty of Medicine Second Department of Surgery Yamagata Japan Second Department of Surgery, Faculty of Medicine, Yamagata University, Yamagata, Japan.

Primary malignant neoplasms of the heart are rare. Cardiac rhabdomyosarcoma is the second most common primary sarcoma. We report a rare case of a 49-year-old woman with a huge biatrial cardiac rhabdomyosarcoma treated by performing surgical resection followed by salvage chemotherapy for local recurrence. Read More

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http://dx.doi.org/10.21470/1678-9741-2018-0414DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7299580PMC

Ascertaining cause of mortality among middle-aged and older persons using computer-coded and expert review verbal autopsies in the China Health and Retirement Longitudinal Study.

Glob Health Action 2020 Dec;13(1):1768502

School of Gerontology, University of Southern California , Los Angeles, CA, USA.

Background: Verbal autopsy is designed to ascertain causes of death that are not registered or certified. Verbal autopsy has been validated in multiple settings but has not been as widely evaluated for older populations as for younger age groups.

Objective: This study aims to provide empirical evidence of the value of verbal autopsy interviews in the context of population-based surveys of older adults by comparing the cause-of-death assignments derived from two methods of interpreting verbal autopsy data. Read More

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http://dx.doi.org/10.1080/16549716.2020.1768502DOI Listing
December 2020

Immunohistochemical neuroendocrine marker expression in primary pulmonary NUT carcinoma: a diagnostic pitfall.

Histopathology 2020 Jun 5. Epub 2020 Jun 5.

University of Padova, Medical School, Department of Cardiac, Thoracic, Vascular Sciences and Public Health, via N. Gustiniani, 2, 35128, Padova, Italy.

NUT carcinoma is a malignant epithelial tumour characterized by the presence of a translocation of the NUT gene (NUTM1, NUT family member 1). Primary pulmonary NUT carcinomas have been reported only in individual case reports or small case series. No pathognomonic morphological and immunohistochemical features have been described. Read More

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http://dx.doi.org/10.1111/his.14166DOI Listing

Clinicopathological characteristics of primary central nervous system lymphoma with low 18F-fludeoxyglucose uptake on brain positron emission tomography.

Medicine (Baltimore) 2020 May;99(20):e20140

Department of Neurosurgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.

Primary central nervous system lymphoma (PCNSL) typically shows a strong uptake of F-fludeoxyglucose (FDG) imaged by positron emission tomography (PET). Uncommonly, PCNSL demonstrates a low uptake on FDG PET. We investigated the clinicopathological characteristics of the unusual cases of PCNSL with low FDG uptake. Read More

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http://dx.doi.org/10.1097/MD.0000000000020140DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7254841PMC

Primary Liver Cancers: Intrahepatic Cholangiocarcinoma and Hepatocellular Carcinoma.

Surg Clin North Am 2020 Jun 16;100(3):535-549. Epub 2020 Apr 16.

Providence Sacred Heart Medical Center, 101 West 8th Avenue, Suite 7050, Spokane, WA 99204, USA.

The incidence of liver cancers has continued to increase over the past few decades and mortality related to liver cancer has increased by more than 2% annually since 2007. This article reviews the essential workup and treatment options necessary for general surgeons as they treat patients with primary liver cancers. Read More

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http://dx.doi.org/10.1016/j.suc.2020.02.013DOI Listing

Is dual-phase SPECT/CT with 99mTc-sestamibi better than single-phase SPECT/CT for lesion localization in patients with hyperparathyroidism?

Medicine (Baltimore) 2020 May;99(19):e19989

Department of Nuclear Medicine, Asan Medical Center, University of Ulsan College of Medicine.

This study aimed to establish an optimal protocol for Tc-sestamibi parathyroid imaging for lesion localization in patients with hyperparathyroidism (HPT).We retrospectively enrolled 35 consecutive patients who underwent dual-phase (at 10 minutes and 120 minutes) Tc-sestamibi parathyroid scintigraphy with single-photon emission computed tomography (SPECT)/computed tomography (CT). Twenty seven patients had primary HPT, and 8 had secondary or tertiary HPT. Read More

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http://dx.doi.org/10.1097/MD.0000000000019989DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7220364PMC

Tumour biomarkers: association with heart failure outcomes.

J Intern Med 2020 May 5. Epub 2020 May 5.

From the, Department of Cardiology, Uni, University Medical Center Groningen, Groningen, the Netherlands.

Background: There is increasing recognition that heart failure (HF) and cancer are conditions with a number of shared characteristics.

Objectives: To explore the association between tumour biomarkers and HF outcomes.

Methods: In 2,079 patients of BIOSTAT-CHF cohort, we measured six established tumour biomarkers: CA125, CA15-3, CA19-9, CEA, CYFRA 21-1 and AFP. Read More

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http://dx.doi.org/10.1111/joim.13053DOI Listing

The incidence and survival outcomes of patients with primary cardiac lymphoma: A SEER-based analysis.

Hematol Oncol 2020 Apr 20. Epub 2020 Apr 20.

Department of Intensive Care Unit, Fujian Cancer Hospital & Fujian Medical University Cancer Hospital, Fuzhou, China.

This study aimed to evaluate the incidence and prognosis of primary cardiac lymphoma (PCL) by using the Surveillance, Epidemiology, and End Results Program (SEER) database. Patients diagnosed with PCL and the disease incidence in the SEER database from 1975 to 2016 were included. Overall survival (OS) and cause-specific survival (CSS) curves were calculated using the Kaplan-Meier method and compared by the log-rank test. Read More

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http://dx.doi.org/10.1002/hon.2741DOI Listing

Rare case of primary pericardial angiosarcoma.

Acta Cardiol 2020 Apr 14:1-3. Epub 2020 Apr 14.

Sands Constellation Heart Institute, Rochester Regional Health, Rochester, NY, USA.

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http://dx.doi.org/10.1080/00015385.2020.1747180DOI Listing

Time-varying analysis of readmission and mortality during the first year after pneumonectomy.

J Thorac Cardiovasc Surg 2020 Jul 7;160(1):247-255.e5. Epub 2020 Mar 7.

Thoracic Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY; Druckenmiller Center for Lung Cancer Research, Memorial Sloan Kettering Cancer Center, New York, NY. Electronic address:

Objectives: Mortality rates of 5% to 10% after pneumonectomy have remained constant during the last decade. To understand the patterns of outcomes after pneumonectomy, we investigated the time-varying risks of readmission and death during the first postoperative year and examined the contributions of specific causes to these patterns over time.

Methods: We retrospectively reviewed all pneumonectomies for lung cancer at our institution from 2000 to 2018. Read More

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http://dx.doi.org/10.1016/j.jtcvs.2020.02.086DOI Listing

A primary neuroendocrine tumor of the left ventricle presenting with diarrhea-an unusual experience and literature review.

Diagn Pathol 2020 Apr 3;15(1):32. Epub 2020 Apr 3.

Department of Pathology, The Affiliated Hospital of Zunyi Medical University, Zunyi, 563000, Guizhou, China.

Background: Neuroendocrine tumors (NETs) can secrete bioactive amines in the bloodstream, resulting in the carcinoid syndrome characterized by diarrhea and flushing. The frequency of occurrence of primary cardiac neuroendocrine neoplasms is lesser than that of metastases, and hence, metastases must be adequately ruled out before diagnosis. Cardiac tumors, both primary and metastatic, mainly result in heart-related symptoms, such as heart failure and acquired valvular dysfunction. Read More

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http://dx.doi.org/10.1186/s13000-020-00935-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7119177PMC

Axillary nodal irradiation practice in the sentinel lymph node biopsy era: Comparison of the contemporary available 3D and IMRT techniques.

Br J Radiol 2020 Jun 1;93(1110):20190351. Epub 2020 Apr 1.

AP-HP. Department of Radiation Oncology and Henri Mondor Breast Center, Créteil, France.

Objective: Our study aimed to compare regional node coverage and doses to the organ at risk (OAR) using conventional technique (CT) "AMAROS" (AT) intensity-modulated radiation therapy (IMRT) techniques in patients receiving regional nodal irradiation (RNI) for breast cancer (BC).

Methods: We included 30 consecutive patients with BC who received RNI including axillary nodes. Two independent and blinded dosimetric RNI plans were generated for all patients. Read More

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http://dx.doi.org/10.1259/bjr.20190351DOI Listing

Association of Daily Step Count and Step Intensity With Mortality Among US Adults.

JAMA 2020 03;323(12):1151-1160

Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland.

Importance: It is unclear whether the number of steps per day and the intensity of stepping are associated with lower mortality.

Objective: Describe the dose-response relationship between step count and intensity and mortality.

Design, Setting, And Participants: Representative sample of US adults aged at least 40 years in the National Health and Nutrition Examination Survey who wore an accelerometer for up to 7 days ( from 2003-2006). Read More

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http://dx.doi.org/10.1001/jama.2020.1382DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7093766PMC

Maneuvering the Management of a Rare Case of Primary Undifferentiated Cardiac Sarcoma.

Am J Case Rep 2020 Mar 21;21:e918878. Epub 2020 Mar 21.

Department of Sarcoma Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.

BACKGROUND Primary cardiac tumors are rare and mostly benign. Cardiac sarcomas are the most common malignant neoplasms of the heart and harbor a dismal prognosis of 6 to 12 months. The diagnosis of cardiac sarcomas may be challenging. Read More

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http://dx.doi.org/10.12659/AJCR.918878DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7117855PMC

Ramosetron versus Palonosetron in Combination with Aprepitant and Dexamethasone for the Control of Highly-Emetogenic Chemotherapy-Induced Nausea and Vomiting.

Cancer Res Treat 2020 Mar 18. Epub 2020 Mar 18.

Department of Clinical Epidemiology and Biostatistics, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

Purpose: The purpose of this study was to compare ramosetron (RAM), aprepitant (APR), and dexamethasone (DEX) [RAD] with palonosetron (PAL), APR, and DEX [PAD] in controlling highly-emetogenic chemotherapy (HEC)-induced nausea and vomiting.

Materials And Methods: Patients were randomly assigned (1:1) to receive RAD or PAD:RAM (0.3 mg intravenously) or PAL (0. Read More

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http://dx.doi.org/10.4143/crt.2019.713DOI Listing

Left atrial tumor thrombus with emboli to the brain and distal extremities: A case report.

Pathol Res Pract 2020 May 29;216(5):152911. Epub 2020 Feb 29.

Department of Radiology University of Missouri, Columbia, MO, United States of America.

Cardiac metastases are an uncommon phenomenon associated with neoplasms from a variety of primary sites. Pulmonary involvement often accompanies metastases involving the left atrium or ventricle and clinical presentation may be associated with stroke or emboli involving distal sites. We report a patient who presented acutely to the Emergency Department with symptoms of a cerebrovascular accident and bilateral cold pulseless lower extremities. Read More

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http://dx.doi.org/10.1016/j.prp.2020.152911DOI Listing

Role and toxicity of radiation therapy in neuroblastoma patients: A literature review.

Crit Rev Oncol Hematol 2020 May 3;149:102924. Epub 2020 Mar 3.

Department of Radiation Oncology, The First Hospital of Jilin University, Changchun, 130021, China. Electronic address:

Neuroblastoma is the most common extracranial solid tumor, arising from primitive sympathetic ganglion cells, in pediatric patients. The unique features of neuroblastoma include variable clinical behaviors, such as rapid progression to death and maturation to benign ganglioneuroma, followed by regression. Radiation therapy (RT) is usually administered to both the primary tumor bed and persistent metastatic sites after induction chemotherapy for high-risk neuroblastoma. Read More

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http://dx.doi.org/10.1016/j.critrevonc.2020.102924DOI Listing
May 2020
4.027 Impact Factor

Pertuzumab, trastuzumab, and docetaxel for HER2-positive metastatic breast cancer (CLEOPATRA): end-of-study results from a double-blind, randomised, placebo-controlled, phase 3 study.

Lancet Oncol 2020 04 12;21(4):519-530. Epub 2020 Mar 12.

IOB Institute of Oncology, Quirónsalud Group, Madrid and Barcelona, Spain; Vall d'Hebron Institute of Oncology (VHIO), Barcelona, Spain.

Background: CLEOPATRA was a phase 3 study comparing the efficacy and safety of pertuzumab, trastuzumab, and docetaxel with placebo, trastuzumab, and docetaxel in patients with HER2-positive metastatic breast cancer. In the primary analysis and subsequent reports, progression-free and overall survival were significantly improved in the pertuzumab group compared with the placebo group. Here, we report the end-of-study analysis of CLEOPATRA. Read More

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http://dx.doi.org/10.1016/S1470-2045(19)30863-0DOI Listing

Cardiac tumors prevalence and mortality: A systematic review and meta-analysis.

Int J Surg 2020 Apr 10;76:178-189. Epub 2020 Mar 10.

Cardiothoracic Surgery Department, Weill Cornell Medicine/New York Presbyterian Hospital, New York, USA.

Objectives: Cardiac tumors and their associated outcomes are poorly characterized. This study sought to comprehensively assess the epidemiology and natural history of primary and secondary malignant cardiac tumors (PMCT and SMCT), a well as establish predictors of mortality.

Methods: A comprehensive literature review was performed to identify articles reporting on PMCTs and SMCTs. Read More

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http://dx.doi.org/10.1016/j.ijsu.2020.02.039DOI Listing

Impact of metformin on malignancy in solid organ transplantation.

Clin Transplant 2020 Jun 5;34(6):e13851. Epub 2020 May 5.

Division of Nephrology, Department of Medicine, Washington University School of Medicine in St. Louis, St. Louis, Missouri.

Malignancy after solid organ transplant is a common occurrence that is associated with increased morbidity and mortality. Literature in the general diabetic population has identified possible antineoplastic properties of metformin. This retrospective study aims to determine if metformin results in a malignancy risk reduction in a cohort of diabetic kidney, liver, and heart transplant recipients. Read More

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http://dx.doi.org/10.1111/ctr.13851DOI Listing

Lymphedema Surveillance and Patient-Reported Anxiety: Comparison Between Volumetric Assessment and Bioimpedance Analysis.

Lymphat Res Biol 2020 Mar 10. Epub 2020 Mar 10.

Department of Breast Services, Digestive Diseases and Surgery Institute, Cleveland Clinic, Cleveland, Ohio.

Lymphedema is a complication of breast cancer therapy associated with substantial anxiety. We designed a prospective, randomized study to assess the psychosocial impact of different surveillance methods for lymphedema. In this open-label study of 38 women undergoing breast cancer surgery, we screened for lymphedema using traditional volumetric measurements (circumferential readings from the wrist to the axilla) versus bioimpedance spectroscopy (BIS) using electric current. Read More

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http://dx.doi.org/10.1089/lrb.2019.0077DOI Listing

Hepatocellular Carcinoma: An Uncommon Metastasis in the Orbit.

Case Rep Oncol Med 2020 26;2020:7526042. Epub 2020 Feb 26.

University of Patras Medical School, Rion 26500, Greece.

Hepatocellular carcinoma (HCC) represents the most common type of primary cancer of the liver and is associated with poor prognosis. It is the most common cause of death in cirrhotic patients and in different studies was shown as the third most common cause of cancer-related deaths worldwide. Each year, approximately half a million people are diagnosed with HCC. Read More

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http://dx.doi.org/10.1155/2020/7526042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7061109PMC
February 2020

Tolerance and efficacy of dose escalation using IMRT combined with chemotherapy for unresectable esophageal carcinoma: Long-term results of 51 patients.

Cancer Radiother 2020 Apr 7;24(2):88-92. Epub 2020 Mar 7.

Radiation Oncology Department, Institut Claudius Regaud, Institut Universitaire du Cancer de Toulouse, 1, avenue Irène Joliot-Curie, 31059 Toulouse Cedex 9, France.

Purpose: The optimal dose in esophageal cancer patients treated with definitive chemoradiation (CRT) remains debated. We herein report on the dosimetric results, treatment-related toxicities and long-term outcomes of escalated dose up to 60Gy delivered with intensity-modulated radiotherapy (IMRT).

Materials And Methods: All consecutive patients that received a definitive CRT>50Gy for an unresectable esophageal carcinoma between 2010 and 2015 were retrospectively evaluated for this study. Read More

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http://dx.doi.org/10.1016/j.canrad.2020.01.006DOI Listing

Chemotherapy-associated nonbacterial thrombotic endocarditis: A radiological mimicker of cardiac amyloidosis requiring histopathologic examination for definitive diagnosis.

Cardiovasc Pathol 2020 Jul - Aug;47:107210. Epub 2020 Feb 11.

Department of Internal Medicine, Division of Cardiovascular Medicine, University Hospitals Cleveland Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH, USA.

Nonbacterial thrombotic endocarditis is a form of a thrombotic angiopathy involving the endothelial lined endocardial surfaces of the heart which includes valves and the chamber walls. Underlying etiologies for nonbacterial thrombotic endocarditis include autoimmune diseases, hypercoagulable states, in the setting of certain malignant neoplasms, and physical injury. The pathogenesis for these processes is that of primary endothelial injury resulting in a thrombotic angiopathy. Read More

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http://dx.doi.org/10.1016/j.carpath.2020.107210DOI Listing

Adherence to Surveillance for Second Malignant Neoplasms and Cardiac Dysfunction in Childhood Cancer Survivors: A Childhood Cancer Survivor Study.

J Clin Oncol 2020 May 6;38(15):1711-1722. Epub 2020 Mar 6.

The Hospital for Sick Children, Toronto, Ontario, Canada.

Purpose: To evaluate childhood cancer survivors' adherence to surveillance protocols for late effects of treatment and to determine the factors affecting adherence.

Methods: Between 2014 and 2016, 11,337 survivors and 2,146 siblings in the Childhood Cancer Survivor Study completed a survey ascertaining adherence to Children's Oncology Group (COG) guidelines for survivors at high risk for second malignant neoplasms or cardiac dysfunction and to the American Cancer Society (ACS) cancer screening guidelines for average-risk populations. Adherence rates and factors affecting adherence were analyzed. Read More

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http://dx.doi.org/10.1200/JCO.19.01825DOI Listing

Free-flap reconstruction in recurrent head and neck cancer: A retrospective review of 124 cases.

Arch Craniofac Surg 2020 Feb 20;21(1):27-34. Epub 2020 Feb 20.

Department of Plastic and Reconstructive Surgery, Hallym University Kangdong Sacred Heart Hospital, Seoul, Korea.

Background: Free-flap reconstruction for recurrent head and neck cancer may be challenging depending on the previous treatments, those are, chemotherapy, radiotherapy, and surgery, including neck dissection or free tissue transfer. Specifically, the previous treatment could compromise the neck vessels, thereby making free-flap reconstruction more difficult. This study aimed to investigate the correlation between previous treatments and vascular compromise of the free flap. Read More

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http://dx.doi.org/10.7181/acfs.2019.00738DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7054190PMC
February 2020

Overall survival and second primary malignancies in men with metastatic prostate cancer.

PLoS One 2020 21;15(2):e0227552. Epub 2020 Feb 21.

EPID Research, Espoo, Finland.

Background: Among prostate cancer (PC) patients, over 90% of distant metastases occur in the bone. PC treatments may be associated with side effects, including second primary malignancies (SPM). There is limited information on the incidence of SPM among men with bone metastatic PC (mPC) and among men with bone metastatic castration-resistant PC (mCRPC). Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0227552PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7034858PMC

Education, Race/Ethnicity, and Causes of Premature Mortality Among Middle-Aged Adults in 4 US Urban Communities: Results From CARDIA, 1985-2017.

Am J Public Health 2020 04 20;110(4):530-536. Epub 2020 Feb 20.

Brita Roy is with the Department of Internal Medicine, Yale School of Medicine, New Haven, CT. Catarina I. Kiefe is with the Department of Population and Quantitative Health Sciences, University of Massachusetts Medical School, Worcester, MA. David R. Jacobs is with the Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis. During the time of the study, David C. Goff was with the Colorado School of Public Health, University of Colorado, Aurora, and the National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD. Donald Lloyd-Jones is with the Feinberg School of Medicine, Northwestern University, Evanston, IL. James M. Shikany is with the Division of Preventive Medicine, University of Alabama at Birmingham. Jared P. Reis is with the National Heart, Lung, and Blood Institute. Penny Gordon-Larsen is with the Department of Nutrition, Gillings School of Global Public Health, University of North Carolina-Chapel Hill. Cora E. Lewis is with the Department of Epidemiology, School of Public Health, University of Alabama at Birmingham.

To assess causes of premature death and whether race/ethnicity or education is more strongly and independently associated with premature mortality in a diverse sample of middle-aged adults in the United States. The Coronary Artery Risk Development in Young Adults study (CARDIA) is a longitudinal cohort study of 5114 participants recruited in 1985 to 1986 and followed for up to 29 years, with rigorous ascertainment of all deaths; recruitment was balanced regarding sex, Black and White race/ethnicity, education level (high school or less vs. greater than high school), and age group (18-24 and 25-30 years). Read More

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http://dx.doi.org/10.2105/AJPH.2019.305506DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7067110PMC

ALK inhibitors for non-small cell lung cancer: A systematic review and network meta-analysis.

PLoS One 2020 19;15(2):e0229179. Epub 2020 Feb 19.

Cardiovascular Research Methods Centre, University of Ottawa Heart Institute, Ottawa, Canada.

Background: We sought to assess the relative effects of individual anaplastic lymphoma kinase (ALK) inhibitors for the treatment of non-small cell lung cancer (NSCLC).

Methods: We searched MEDLINE, Embase, Cochrane CENTRAL, and grey literature (July 23, 2019) for randomized controlled trials (RCTs) that included participants with ALK- or ROS1-positive NSCLC who received any ALK inhibitor compared with placebo, another ALK inhibitor, or the same ALK inhibitor at a different dose. The primary outcome was treatment-related death. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0229179PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7029857PMC

Late mortality and chronic health conditions in long-term survivors of early-adolescent and young adult cancers: a retrospective cohort analysis from the Childhood Cancer Survivor Study.

Lancet Oncol 2020 03 14;21(3):421-435. Epub 2020 Feb 14.

Department of Pediatrics, University of Chicago, Chicago, IL, USA. Electronic address:

Background: Treatment outcomes among survivors of cancer diagnosed during adolescence and early young adulthood have not been characterised independently of survivors of cancers diagnosed during childhood. We aimed to describe chronic health conditions and all-cause and cause-specific mortality among survivors of early-adolescent and young adult cancer.

Methods: The Childhood Cancer Survivor Study (CCSS) is a retrospective cohort study with longitudinal follow-up of 5-year survivors diagnosed with cancer before the age of 21 years at 27 academic institutions in the USA and Canada between 1970 and 1999. Read More

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http://dx.doi.org/10.1016/S1470-2045(19)30800-9DOI Listing

Cardiac Myxoma with Cerebral Metastases and Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma: A Case Report and Review.

J Neurol Surg Rep 2020 Jan 11;81(1):e1-e6. Epub 2020 Feb 11.

Department of Neurosurgery, Baptist Health South Florida, Miami, Florida, United States.

 Cardiac myxomas, the most common primary cardiac tumors, are generally benign neoplasms. Primary cardiac lymphoma is a rare cardiac malignancy with a very poor prognosis. Here we present a case of a cardiac myxoma with cerebral metastases and chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) arising within the cerebral metastases. Read More

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http://dx.doi.org/10.1055/s-0039-3399570DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7012640PMC
January 2020

Microenvironment in Cardiac Tumor Development: What Lies Beyond the Event Horizon?

Adv Exp Med Biol 2020 ;1226:51-56

Department of Cardiothoracic Surgery, New York Presbyterian Hospital, Weill Cornell Medicine, New York City, NY, USA.

Cardiac tumors are found in less than 1% of adult and pediatric autopsies. More than three-fourths of primary cardiac neoplasms are benign, with myxomas and rhabdomyomas being the most common cardiac tumors seen in adults and children, respectively. Primary malignant cardiac tumors are extremely rare, whereas metastatic lesions can be seen in approximately 8% of patients dying from cancer. Read More

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http://dx.doi.org/10.1007/978-3-030-36214-0_4DOI Listing
February 2020

Shape of the Heart: A 68-Year-Old Man With a Primary Cardiac Non-Hodgkin Lymphoma.

Authors:
Whoon Jong Kil

Int J Radiat Oncol Biol Phys 2020 03;106(3):460-461

Radiation Oncology, WellSpan Health, Chambersburg, Pennsylvania. Electronic address:

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http://dx.doi.org/10.1016/j.ijrobp.2018.12.024DOI Listing

Radiotherapy of prostate cancer: impact of treatment characteristics on the incidence of second tumors.

BMC Cancer 2020 Feb 3;20(1):90. Epub 2020 Feb 3.

Radiation Oncology Center, Department of Experimental, Diagnostic and Specialty Medicine - DIMES, University of Bologna, S. Orsola-Malpighi Hospital, via Giuseppe Massarenti 9, 40138, Bologna, Italy.

Background: It has been hypothesized that radiotherapy (RT) techniques delivering radiations to larger volumes (IMRT, VMAT) are potentially associated with a higher risk of second primary tumors. The aim of this study was to analyse the impact of RT technique (3D-CRT vs IMRT/VMAT) on the incidence of second tumors in prostate cancer (PCa) patients.

Methods: A retrospective study on 2526 previously irradiated PCa patients was performed. Read More

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http://dx.doi.org/10.1186/s12885-020-6581-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6998272PMC
February 2020

Primary pigmented meningeal melanocytoma originating in Meckel cave in a patient with carney complex: A case report.

Medicine (Baltimore) 2020 Jan;99(3):e18783

Neurosurgery Department, Imam Abdulrahman Bin Faisal University, King Fahd Hospital of the University, Saudi Arabia.

Rationale: Primary melanin-producing tumors are rare extra-axial neoplasms OPEN of the central nervous system. In the literature, few case reports have discussed neoplasms involving the cavernous sinus; of these, only 4 have reported on neoplasms originating in Meckel cave. The diagnostic approach, including clinical and radiological analysis, is challenging, and cytopathological assessment with a molecular basis is the best approach to discriminate between these lesions. Read More

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http://dx.doi.org/10.1097/MD.0000000000018783DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7220446PMC
January 2020

Physical activity and risks of breast and colorectal cancer: a Mendelian randomisation analysis.

Nat Commun 2020 01 30;11(1):597. Epub 2020 Jan 30.

Section of Nutrition and Metabolism, International Agency for Research on Cancer, Lyon, France.

Physical activity has been associated with lower risks of breast and colorectal cancer in epidemiological studies; however, it is unknown if these associations are causal or confounded. In two-sample Mendelian randomisation analyses, using summary genetic data from the UK Biobank and GWA consortia, we found that a one standard deviation increment in average acceleration was associated with lower risks of breast cancer (odds ratio [OR]: 0.51, 95% confidence interval [CI]: 0. Read More

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http://dx.doi.org/10.1038/s41467-020-14389-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6992637PMC
January 2020
10.742 Impact Factor

Combined one-stage minimally invasive surgery for primary pulmonary carcinoma and mitral regurgitation.

J Cardiothorac Surg 2020 Jan 30;15(1):31. Epub 2020 Jan 30.

Department of Cardiovascular Surgery, The First Affiliated Hospital , Jinan University, Guangzhou.No.613 Whampoa Avenue, Tianhe District, Guangzhou, China.

Background: We report the first successful short-term outcome of one-stage minimally invasive surgery (MIS) mitral valve repair and video-assisted thoracoscopic surgery (VATS) lobectomy.

Case Presentation: We report the first successful short-term outcome of combined one-stage video-assisted thoracoscopic surgery lobectomy and minimally invasive surgery in a patient with operable primary right upper lobe adenocarcinoma and mitral regurgitation. Post- operative recovery was uneventful, and follow-up at 6 weeks confirmed an excellent surgical and oncologic outcome. Read More

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http://dx.doi.org/10.1186/s13019-020-1072-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6990509PMC
January 2020

The Use of Gonadotropin-Releasing Hormone Agonist Does Not Affect the Development of Cardiovascular Disease in Prostate Cancer Patients: a Nationwide Population-Based Cohort Study.

J Korean Med Sci 2020 Feb 3;35(4):e47. Epub 2020 Feb 3.

Department of Urology, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang, Korea.

Background: The objective of this study was to investigate whether androgen deprivation therapy (ADT) with gonadotropin-releasing hormone agonist (GnRHa) in prostate cancer (Pca) patients is associated with cardiovascular disease in the cohort based from the entire Korean population.

Methods: Using the Korean National Health Insurance database, we conducted an observational study of 579,377 men who sought treatment for Pca between January 1, 2012 and December 31, 2016. After excluding patients with previously diagnosed cardiovascular disease or who had undergone chemotherapy, we extracted the data from 2,053 patients who started GnRHa (GnRHa users) and 2,654 men who were newly diagnosed with Pca (GnRHa nonusers) between July 1, 2012, and December 31, 2012, with follow-up through December 31, 2016. Read More

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http://dx.doi.org/10.3346/jkms.2020.35.e47DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6995814PMC
February 2020

"Dark corridors" in 5-ALA resection of high-grade gliomas: combining fluorescence-guided surgery and contrast-enhanced ultrasonography to better explore the surgical field.

J Neurosurg Sci 2019 Dec;63(6):688-696

Institute of Neurosurgery, A. Gemelli University Polyclinic, IRCCS and Foundation, Sacred Heart Catholic University, Rome, Italy.

Background: Increasing the extent of resection (EOR) is considered a main goal in high grade glioma (HGG) surgery. Significant advancements have been recently made to assist surgery: namely the use of 5-aminolevulinic acid (5ALA) and the application of contrast-enhanced ultrasound (CEUS) embody two of the most recently introduced tools in the neuro-oncology field. A combined approach including the two techniques has been suggested in literature. Read More

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http://dx.doi.org/10.23736/S0390-5616.19.04862-8DOI Listing
December 2019

[Perioperative Outcomes of Patients Undergoing Pulmonary Resection for Lung Cancer after Coronary Stenting].

Zhongguo Fei Ai Za Zhi 2020 01;23(1):36-40

Department of Thoracic Surgery, Peking University First Hospital, Beijing 100034, China.

Background: It is common for patients with lung cancer to have concomitant coronary artery disease, some of them have underwent coronary stenting and accepted antiplatelet therapy. Whether antiplatelet agents should be continued in the perioperative period remains controversial, especially in patients requiring lung cancer resection with coronary artery stents. We reviewed the data of our institute to clarify the perioperative outcomes of this specific population. Read More

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http://dx.doi.org/10.3779/j.issn.1009-3419.2020.01.06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7007396PMC
January 2020

Do patients benefit from total intracorporeal robotic radical cystectomy?: A comparative analysis with extracorporeal robotic radical cystectomy from a Korean multicenter study.

Investig Clin Urol 2020 01 18;61(1):11-18. Epub 2019 Dec 18.

Department of Urology, Korea University College of Medicine, Seoul, Korea.

Purpose: This study aimed to compare complications, perioperative parameters, and oncologic outcomes between robot-assisted radical cystectomy (RARC) with extracorporeal urinary diversion (ECUD) and RARC with intracorporeal urinary diversion (ICUD).

Materials And Methods: Between 2007 and 2017, 362 patients who underwent RARC with ECUD or ICUD at multiple tertiary referral institutions were assessed. The primary endpoints were complication rates. Read More

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http://dx.doi.org/10.4111/icu.2020.61.1.11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6946824PMC
January 2020

Palliative care for non-cancer conditions in primary care: a time trend analysis in the UK (2009-2014).

BMJ Support Palliat Care 2020 Jan 13. Epub 2020 Jan 13.

Department of Health Sciences, University of York and Hull York Medical School, York, UK.

Objectives: While guidelines recommend palliative care in non-cancer conditions, this has not been widely implemented. We examined whether the recording of a palliative care approach and the numbers of hospital deaths for deceased patients with heart failure, dementia, chronic obstructive pulmonary disease (COPD) and cancer have changed since the UK End-of-Life Care Strategy was introduced.

Methods: We conducted sequential cross-sectional studies of decedents within the UK's Clinical Practice Research Datalink and Hospital Episode Statistics. Read More

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http://dx.doi.org/10.1136/bmjspcare-2019-001833DOI Listing
January 2020

Long-term outcome of partial P450 side-chain cleavage enzyme deficiency in three brothers: the importance of early diagnosis.

Eur J Endocrinol 2020 Mar;182(3):K15-K24

Child Health Section of University of Glasgow School of Medicine, Queen Elizabeth University Hospital, Glasgow, UK.

Objective: CYP11A1 mutations cause P450 side-chain cleavage (scc) deficiency, a rare form of congenital adrenal hyperplasia with a wide clinical spectrum. We detail the phenotype and evolution in a male sibship identified by HaloPlex targeted capture array.

Family Study: The youngest of three brothers from a non-consanguineous Scottish family presented with hyperpigmentation at 3. Read More

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http://dx.doi.org/10.1530/EJE-19-0696DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7087497PMC

A 63-year-old woman with multiple secondary tumours.

Heart 2020 02;106(3):202-241

2nd Department of Internal Medicine, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.

Clinical introductionA 63-year-old woman recently diagnosed with lung metastasis, after routine chest radiography, was admitted to our hospital for unspecified symptoms, such as dyspnoea on minimal exertion and dry cough. Physical examination showed uncommon signs. The electrocardiogram showed sinus rhythm and incomplete left bundle branch block. Read More

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http://dx.doi.org/10.1136/heartjnl-2019-316060DOI Listing
February 2020

Primary cardiac lymphomas may present under different phenotypes.

Asian Cardiovasc Thorac Ann 2020 Mar 8;28(3):168-171. Epub 2020 Jan 8.

Clinic of Cardiac Surgery, University Hospital Zürich, Zürich, Switzerland.

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http://dx.doi.org/10.1177/0218492319900597DOI Listing