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BMC Urol 2020 Jun 30;20(1):80. Epub 2020 Jun 30.

Department of Pathology, Microbiology and Forensic Medicine, School of Medicine, University of Jordan, Amman, Jordan.

Background: Myxoma is a relatively rare mesenchymal tumor seen mainly in the heart and skin. Renal myxomas in particular are exceptionally rare where only 17 cases were previously reported in the English Language literature. Only 2 of the 17 reported cases were located in the renal sinus/pelvis. Read More

J Card Surg 2020 Jun 29. Epub 2020 Jun 29.

Department of Cardiothoracic Vascular Surgery, Cardio-Thoracic Sciences Center, All India Institute of Medical Sciences, New Delhi, India.

Background: Various patch materials to close large atrial septal defects (ASDs) are autologous pericardium or a large of prosthetic patches which may be associated with infrequent but definite problems. We describe our experience with the use of the right atrial free wall patch over the last two decades.

Methods And Results: Between July 1998 and December 2017, 157 patients (mean age 14. Read More

Echocardiography 2020 Jun 21. Epub 2020 Jun 21.

Department of Cardiac MRI, Allegheny General Hospital, Pittsburgh, PA, USA.

Cardiac masses are divided into neoplastic and non-neoplastic. They usually represent a diagnostic challenge given their relative rarity, their infrequent symptoms, and the overall difficulty with dynamic imaging of the heart. While echocardiography is useful in the initial evaluation of a suspected mass, cardiac magnetic resonance (CMR) imaging is the best imaging modality to characterize cardiac tumors due to its superior tissue characterization and its higher contrast resolution. Read More

Pan Afr Med J 2020 6;36. Epub 2020 May 6.

Razi Clinical Research Development Unit (RCRDU), Birjand University of Medical Sciences, Birjand, Iran.

Embolic events are rare presentation of myxoma, which is one of the most prevalent benign cardiac tumors. Here we report the case of a 53-year-old man with presentation of acute anterior infarction and occlusion of the left anterior descending artery in association with left atrial myxoma. Intracoronary aspiration thrombectomy along with frequent balloon inflation was failed to recover distal coronary blood flow. Read More

Eur J Cardiothorac Surg 2020 Jun 15. Epub 2020 Jun 15.

Department of Cardiac Surgery, Glenfield Hospital, Leicester, UK.

Ear Nose Throat J 2020 Jun 11:145561320927913. Epub 2020 Jun 11.

Department of Otolaryngology-Head and Neck Surgery, Tahar Sfar Hospital, Mahdia, Tunisia.

Myxoma is a benign myxoid tumor of connective tissue that develops primarily in the heart. At the level of the external auditory canal, it is extremely rare. It can be isolated or associated with Carney syndrome. Read More

Heart Surg Forum 2020 May 8;23(3):E292-E294. Epub 2020 May 8.

Department of Cardiac Surgery, Qilu Hospital, Shandong University, Jinan, China.

The patient was a 69-year-old male patient with cancer in the right lung and whose preoperative examination showed left atrial myxoma. Simultaneous surgery for both cardiac myxoma resection and a lobectomy by totally endoscopic surgery without robotic assistance was performed. First, the cardiac tumor on the heart was removed using a cardiopulmonary bypass (CPB), then a lobectomy without any new incisions was performed. Read More

J Cardiovasc Imaging 2020 May 27. Epub 2020 May 27.

Department of Radiology, Gold Coast University Hospital, Southport, QLD, Australia.

Ultrasound J 2020 May 25;12(1):29. Epub 2020 May 25.

Prehospital and Hospital Emergency Research Center, Department of Emergency Medicine, Tehran University of Medical Sciences, Tehran, Iran.

Background: Cardiac syncope can result from an atrial myxoma due to outflow obstruction. Myxoma is the most common primary cardiac tumor that may cause sudden death and the nonspecific symptoms may make early diagnosis difficult.

Case Presentation: A 27-year-old man presented to our emergency department after two episodes of syncope and severe fatigue. Read More

Kyobu Geka 2020 May;73(5):380-383

Department of Cardiovascular Surgery, Sendai Kousei Hospital, Sendai, Japan.

A 44-year-old male presented to our hospital with exertional dyspnea. Transthoracic echocardiography revealed a large cystic mass in the left atrium obstructing the mitral valve orifice. Transesophageal echocardiography during emergency operation showed a large cystic mass along with a solid part near the stalk. Read More

Circ Cardiovasc Imaging 2020 May 6;13(5):e010277. Epub 2020 May 6.

Department of Ultrasound (B.W., H.L., Y.X., L.Z., Y.L., M.X.), Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Neuropediatrics 2020 May 5. Epub 2020 May 5.

Paediatric Neurology and Neurophysiology Unit, Department of Women's and Children's Health, University Hospital of Padua, Padova, Italy.

Background:  Cardiac disorders are the second leading cause of pediatric arterial ischemic stroke (AIS). Limited literature is available on pediatric AIS caused by cardiac myxoma, a rare tumor in childhood.

Methods:  We describe a new case of pediatric AIS due to a previously unknown atrial myxoma and we conduct a literature review on children with AIS due to cardiac myxoma. Read More

Eur J Ophthalmol 2020 Apr 27:1120672120914232. Epub 2020 Apr 27.

Department of Ophthalmology, Advanced Eye Center, Postgraduate Institute of Medical Education & Research, Chandigarh, India.

The changes in the cardiovascular system are associated with ocular manifestations, often as a consequence of pathological alteration in the ocular vasculature. The ease of visualization of these retinal changes makes the eye a window to the cardiovascular system. Certain congenital cardiac defects lead to changes in the retinal vascularity due to increased tortuosity and dilatation. Read More

Biomed Res Int 2020 14;2020:9758302. Epub 2020 Feb 14.

Department of Vascular Surgery, Qilu Hospital of Shandong University, Jinan, Shandong 250012, China.

Purpose: This study aimed to retrospectively review the diagnosis and surgical treatment of uterine intravenous leiomyomatosis (IVL).

Methods: The clinical data of 14 patients with uterine IVL admitted to our hospital between 2013 and 2018 were retrospectively analyzed, including their demographics, imaging results, surgical procedures, perioperative complications, and follow-up results.

Results: The tumors were confined to the pelvic cavity in 7 patients, 1 into the inferior vena cava, 4 into the right atrium, and 2 into the pulmonary artery (including 1 into the superior vena cava). Read More

Eur Heart J 2020 Apr 24. Epub 2020 Apr 24.

Department of Biology, San Diego State University, San Diego, CA, USA.

Eur Heart J 2020 Apr 24. Epub 2020 Apr 24.

Department of Experimental and Clinical Medicine, Molecular and Cellular Cardiology, Magna Graecia University, Viale Europa, 88100 Catanzaro, Italy.

Aims: Cardiac myxomas usually develop in the atria and consist of an acid-mucopolysaccharide-rich myxoid matrix with polygonal stromal cells scattered throughout. These human benign tumours are a valuable research model because of the rarity of cardiac tumours, their clinical presentation and uncertain origin. Here, we assessed whether multipotent cardiac stem/progenitor cells (CSCs) give rise to atrial myxoma tissue. Read More

Saudi J Anaesth 2020 Apr-Jun;14(2):217-220. Epub 2020 Mar 5.

Department of Cardiac Surgery, King Fahd Cardiac Center, College of Medicine, King Saud University Medical City, Riyadh, Kingdom of Saudi Arabia.

Persistent left superior vena cava (PLSVC) is a rare and asymptomatic congenital cardiovascular anomaly. Being asymptomatic, PLSVC was usually discovered while performing interventions (such as insertion of central lines, Swan-Ganz catheters, or placing pacemakers) through the left internal jugular vein or left subclavian veins. Commonly, PLSVC is detected not only as an isolated congenital anomaly, but also it can be associated with many other cardiac anomalies. Read More

J Card Surg 2020 May 15;35(5):1148-1151. Epub 2020 Apr 15.

Department of Anaesthesia, National University Hospital, Singapore, Singapore.

Background And Aim: Cardiac sarcoma is a rare condition and may mimic atrial myxoma. We present a case report of a man with a cardiac sarcoma.

Method: Case report presentation. Read More

Int J Hematol 2020 Jul 13;112(1):65-73. Epub 2020 Apr 13.

Institution and Department, Department of Hematology, Hangzhou First People's Hospital Affiliated to Nanjing Medical University, Graduate School of Nanjing Medical University, Shangcheng District, No. 261, Huansha Road, Hangzhou, Zhejiang, China.

The heart is a rare primary site of lymphoma, and cardiac involvement is thought to bring a poorer prognosis. A framework of known clinical presentations, diagnostic features, disease complications, treatments, and outcomes to improve prognostication was constructed by a systematic review in 2011. However, some aspects must be discussed further in light of recent advances in lymphoma research. Read More

Cureus 2020 Feb 28;12(2):e7136. Epub 2020 Feb 28.

Cardiology, Onze Lieve Vrouwe Gasthuis (OLVG), Amsterdam, NLD.

A cardiac papillary fibroelastoma (CPFE) is reported to be the second most common cardiac neoplasm after myxoma cordis. CPFEs are histologically benign, frequently asymptomatic, but highly thrombogenic, which could lead to systemic and peripheral embolization. We present a case of a 68-year-old-patient, with a history of angioosteohypertrophy syndrome, who presented at our emergency department (ED) with symptoms of transient ischemic attacks. Read More

Int J Clin Exp Pathol 2019;12(3):1115. Epub 2019 Mar 1.

Department of Pathology, Xiangya Hospital, Central South University Changsha, Hunan, People's Republic of China.

[This corrects the article on p. 5497 in vol. 11, PMID: 31949636. Read More

J Clin Endocrinol Metab 2020 Jun;105(6)

Division of Diabetes and Endocrinology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan.

Context: Germline mutations in fumarate hydratase (FH) gene are known to cause hereditary leiomyomatosis and renal cell carcinoma (HLRCC) and are occasionally accompanied with cutaneous and uterine leiomyoma or cortisol-producing adrenocortical hyperplasia. However, the association between FH mutations and cardiac or adrenocortical tumors has remained unknown. Here, we identified a novel deletion in FH, exhibiting cardiac myxoma and subclinical Cushing syndrome due to adrenocortical tumor. Read More

Pediatr Pulmonol 2020 Jun 3;55(6):E1-E3. Epub 2020 Apr 3.

Division of Pediatric Cardiac Surgery, University Hospital Muenster, Muenster, Germany.

Cardiac myxomas are rare occurrences in pediatric populations, as are pulmonary artery aneurysms. We report a 17-year-old adolescent with right atrial cardiac myxoma and concomitant multiple peripheral pulmonary artery aneurysms. Histological examination indicated infiltration of the pulmonary artery wall through the embolic cardiac myxoma cells, thereby weakening it. Read More

Neuropathology 2020 Jun 30;40(3):295-301. Epub 2020 Mar 30.

Department of Pathology, All India Institute of Medical Sciences, New Delhi, India.

Atrial myxomas are the most common primary benign cardiac tumors. The embolization of tumor particles is not infrequent, and in nearly half of them, the cerebral arteries are affected, usually leading to embolic ischemic stroke. Formation of intracranial aneurysms, development of parenchymal brain metastasis, and intracerebral hemorrhage due to ruptured aneurysms are rarer. Read More

Singapore Med J 2020 Mar 31. Epub 2020 Mar 31.

Department of Cardiology, National Heart Centre Singapore, Singapore

Introduction: Cardiac myxoma is the most common cardiac tumour. In this study, we summarise our 17-year experience on the clinical presentation of cardiac myxoma at National Heart Centre Singapore, Singapore.

Methods: Between January 2000 and December 2016, retrospective data was reviewed for all consecutive patients who underwent surgical resection of cardiac myxoma. Read More

J Card Surg 2020 May 29;35(5):1094-1097. Epub 2020 Mar 29.

Department of Oncological Urology, Fundación Clínica Shaio, Bogota, Colombia.

Leiomyomatosis is a uterine condition that can rarely present with extrauterine involvement. Intravenous and intracardiac extensions are extremely rare presentations and, in these cases, the intra-cardiac mass may be confused with a cardiac myxoma and can be associated with pulmonary embolism. Here we report two cases of successful surgically removed intracardiac leiomyomas under cardiopulmonary bypass. Read More

J Stroke Cerebrovasc Dis 2020 Jun 24;29(6):104796. Epub 2020 Mar 24.

Department of Neurology, Yangpu Hospital Tongji University School of Medicine, Shanghai, China. Electronic address:

We administered intravenous thrombolytic therapy to a 51-year-old female patient with a 101-min stroke onset. The patient was unconscious during the manifestation of symptoms. Computed tomography angiography examination of the intracranial artery at the time of admission suggested that the left middle cerebral artery was occluded. Read More

BMC Cardiovasc Disord 2020 Mar 25;20(1):149. Epub 2020 Mar 25.

Department of Cardiovascular Surgery, Xiangya Hospital, Central South University, Xiangya Rd 87, Changsha, 410008, China.

Background: Cardiac myxoma (CM) is the most common type of primary cardiac tumors. The prevalence of primary cardiac tumors is 0.0017-0. Read More

Kardiol Pol 2020 Apr 24;78(4):269-277. Epub 2020 Mar 24.

Cardiac myxoma is the most common benign cardiac tumor. It is located in the left atrium and typically arises from the foramen ovale in approximately 75% of the general patient population, in the right atrium in 23%, and in the ventricles in only 2%. Symptoms depend on its size, mobility, and relation to surrounding cardiac structures. Read More

BMJ Case Rep 2020 Mar 19;13(3). Epub 2020 Mar 19.

Department of Cardiology, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.

A 37-year-old man was presented in outpatient clinic of cardiology department with symptoms of easy fatigability and progressive increasing generalised anasarca since 5 months. Echocardiogram showed large mass of 9.8×7. Read More

Cureus 2019 Jun 11;11(6):e4884. Epub 2019 Jun 11.

Internal Medicine, Oak Hill Hospital, Brooksville, USA.

Cardiac myxoma is an uncommon diagnosis but presents with common manifestations. There is a wide range of symptomatology from non-specific fever and weight loss to stroke-like symptoms. It is also one of the rare causes of cardiac syncope and thromboembolic events. Read More

Int J Surg 2020 Apr 10;76:178-189. Epub 2020 Mar 10.

Cardiothoracic Surgery Department, Weill Cornell Medicine/New York Presbyterian Hospital, New York, USA.

Objectives: Cardiac tumors and their associated outcomes are poorly characterized. This study sought to comprehensively assess the epidemiology and natural history of primary and secondary malignant cardiac tumors (PMCT and SMCT), a well as establish predictors of mortality.

Methods: A comprehensive literature review was performed to identify articles reporting on PMCTs and SMCTs. Read More

Surg Clin North Am 2020 Apr 1;100(2):219-236. Epub 2020 Feb 1.

Department of Cardiovascular & Thoracic Surgery, Lenox Hill Hospital, Northwell Health, 130 East 77th Street, 4th Floor, New York, NY 10075, USA; Cardiovascular & Thoracic Surgery, Zucker School of Medicine at Hofstra/Northwell, Hempstead, NY, USA; Robotic Cardiac Surgery, Northwell Health, 130 East 77th Street, 4th Floor, New York, NY 10075, USA. Electronic address:

Robotic minimally invasive direct coronary artery bypass is the most common robotic coronary procedure performed worldwide. It can be used to treat isolated left anterior descending (LAD) stenosis or can be coupled with percutaneous coronary intervention to diseased non-LAD targets in patients with multivessel disease. Virtually all types of mitral valve repair can be performed using the robot; valve replacement can also be undertaken. Read More

Tumori 2020 Mar 12:300891620909421. Epub 2020 Mar 12.

Institute of Haematology "L. e A. Seràgnoli," University of Bologna, Bologna, Italy.

Background: B-cell chronic lymphocytic leukemia (B-CLL) is a lymphoproliferative disorder consisting of clonal proliferation and accumulation of small, mature, CD5-positive B-lymphocytes in the blood, bone marrow, and lymphoid tissues. Among extranodal localizations, cardiac involvement is extremely rare: to our knowledge, there are no findings reported in the literature of concomitant B-CLL diagnosis in the context of atrial myxoma (so-called collision tumours) and the best strategy to treat these malignancies is unclear.

Case Report: We report the case of a 67-year-old woman diagnosed with B-CLL and atrial myxoma. Read More

J Cardiol Cases 2020 Mar 16;21(3):89-92. Epub 2019 Nov 16.

Black Country Pathology Services, New Cross Hospital, Wolverhampton, UK.

A 31-year-old female with a history of polycystic ovary syndrome and two recent miscarriages presented with symptoms of a transient ischemic attack. Echocardiography to assess for possible embolic source identified a 4.8 cm left atrial mass, presumed to be an atrial myxoma. Read More

QJM 2020 Mar 6. Epub 2020 Mar 6.

Department of Neurology, the First Affiliated Hospital of Wannan Medical College, Wuhu, Anhui Province, PR China.

BMC Cardiovasc Disord 2020 Mar 5;20(1):119. Epub 2020 Mar 5.

University of Central Florida College of Medicine, Graduate Medical Education, Orlando, FL, 32827, USA.

Background: A cardiac myxoma in a young person may pose a diagnostic challenge as symptoms may be variable and the differential diagnosis is wide. The differential diagnosis can include rheumatic mitral valve disease, pulmonary hypertension, endocarditis, myocarditis and vasculitis.

Case Presentation: This case report involves a 49 years old female with a 2. Read More

Oxf Med Case Reports 2020 Feb 28;2020(2):omaa012. Epub 2020 Feb 28.

Third Department of Internal Medicine, Evaggelismos General Hospital, Athens, Greece.

Diffuse thickening, a layered appearance of the gallbladder wall and the accumulation of surrounding fluid are considered as sensitive and relatively specific imaging findings of gallbladder inflammation. In the absence of gallstones, the diagnosis of acalculous cholecystitis can be further supported by the presence of fever, epigastric pain, right upper abdominal quadrant (RUQ) tenderness on inspiration and elevated markers of inflammation. In this report, we describe a 35-year-old schoolteacher who presented with all of the above clinical, laboratory and imaging findings that were eventually attributed to gallbladder oedema and liver congestion (abdominal imaging and RUQ tenderness) caused by an atrial myxoma interfering, with the atrioventricular circulation of the right heart and causing constitutional manifestations (fever and elevated markers of inflammation). Read More

Cureus 2020 Jan 19;12(1):e6704. Epub 2020 Jan 19.

Internal Medicine, University of Central Florida College of Medicine, Ocala, USA.

Despite the huge improvement in cardiovascular care over the past several decades and the decline in cardiovascular deaths, sudden cardiac death (SCD) continues to present a nationwide health problem accounting to more than half of all deaths from cardiovascular disease. Majority of these cases are related to coronary artery disease and arrhythmias, however, a very small number of these cases are secondary to cardiac neoplasms. These neoplasms commonly present with conduction abnormalities or symptoms secondary to valvular disease such as dyspnea, orthopnea, cough and/or edema. Read More

CASE (Phila) 2020 Feb 6;4(1):33-38. Epub 2019 Dec 6.

Saint Francis Hospital, Tulsa, Oklahoma.

CASE (Phila) 2020 Feb 25;4(1):28-32. Epub 2019 Nov 25.

Department of Surgical Sciences, Cardiothoracic Surgery and Anesthesia, Uppsala University Hospital, Uppsala, Sweden.

Circ Cardiovasc Imaging 2020 Mar 26;13(3):e010004. Epub 2020 Feb 26.

Department of Cardiology, Franciscus Gasthuis & Vlietland, Rotterdam, the Netherlands (S.W.K., S.M.S., B.M.v.D.).

J Int Adv Otol 2020 Feb 18. Epub 2020 Feb 18.

Department of Pathology, Necmettin Erbakan University Meram Medical Faculty, Konya, Turkey.

The primary head and neck myxomas are rare, generally arising from the mandible, maxilla, and oral cavity. Other anatomical areas, such as cardiac myxomas, may also have metastases to the head and neck regions. The middle ear is an extremely rare location for myxomas. Read More

J Neurol Surg Rep 2020 Jan 11;81(1):e1-e6. Epub 2020 Feb 11.

Department of Neurosurgery, Baptist Health South Florida, Miami, Florida, United States.

 Cardiac myxomas, the most common primary cardiac tumors, are generally benign neoplasms. Primary cardiac lymphoma is a rare cardiac malignancy with a very poor prognosis. Here we present a case of a cardiac myxoma with cerebral metastases and chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) arising within the cerebral metastases. Read More

Indian J Pathol Microbiol 2020 Jan-Mar;63(1):144-145

Department of Pathology, All India Institute of Medical Sciences, New Delhi, India.

Adv Exp Med Biol 2020 ;1226:51-56

Department of Cardiothoracic Surgery, New York Presbyterian Hospital, Weill Cornell Medicine, New York City, NY, USA.

Cardiac tumors are found in less than 1% of adult and pediatric autopsies. More than three-fourths of primary cardiac neoplasms are benign, with myxomas and rhabdomyomas being the most common cardiac tumors seen in adults and children, respectively. Primary malignant cardiac tumors are extremely rare, whereas metastatic lesions can be seen in approximately 8% of patients dying from cancer. Read More

J Card Surg 2020 Mar 4;35(3):703-705. Epub 2020 Feb 4.

Cardiac Surgery Unit, Ospedale dell'Angelo Mestre, Venice, Italy.

Cardiac calcified thrombus is a rare non-neoplastic cardiac mass that can present like an intra-cardiac tumor. The finding of a calcified thrombus in the inferior vena cava is described in patients with permanent central venous line or in presence of recurrent pulmonary embolism. The aim of the study is to describe a rare case of cardiac calcified thrombus in patient without comorbidities. Read More

Cardiol J 2019 ;26(6):806-807

Department of Heart Diseases, The Medial Centre of Postgraduate Education, Warsaw, Poland.

Quant Imaging Med Surg 2020 Jan;10(1):294-313

Department of Radiology, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China.

Cardiac magnetic resonance (CMR) offers superior advantages in cardiac imaging due to supplying a greater field of view, excellent soft-tissue imaging, and multiplanar imaging capabilities. CMR imaging can evaluate the characteristics of cardiac tumors by visualizing the relationship between the tumor and surrounding tissues, and plays a vital role in assisting the formulation of the surgical plan, the assessment of tumor progression, and the monitoring of postoperative tumor recurrence and metastasis. In this review, we present the clinical manifestations and imaging features of different cardiac tumors. Read More