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Hum Mol Genet 2019 Apr 22. Epub 2019 Apr 22.

Department of Medicine.

Mutations in LMNA encoding lamin A/C and EMD encoding emerin cause cardiomyopathy and muscular dystrophy. Lmna null mice develop these disorders and have a lifespan of 7-8 weeks. Emd null mice show no overt pathology and have normal skeletal muscle but with regeneration defects. Read More

Comput Biol Med 2019 Mar 23;108:263-275. Epub 2019 Mar 23.

School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom. Electronic address: https://kclpure.kcl.ac.uk/portal/martin.bishop.html.

Identification of targets for catheter ablation of ventricular tachycardias (VTs) remains a significant challenge. VTs are often driven by re-entrant circuits resulting from a complex interaction between the front (activation) and tail (repolarization) of the electrical wavefront. Most mapping techniques do not take into account the tissue repolarization which may hinder the detection of ablation targets. Read More

Phytomedicine 2018 Nov 28;59:152774. Epub 2018 Nov 28.

Chemical Biology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China. Electronic address:

Background: Diabetes mellitus is a well-known risk factor for the development of heart failure. Inflammation and oxidative stress play a key role in the development of diabetic cardiomyopathy (DCM), and this nexus represents an attractive target to combat this disease. Naturally occurring flavonoid luteolin exhibits both anti-inflammatory and antioxidant activities in various systems. Read More

Stem Cell Res 2019 Apr 12;37:101436. Epub 2019 Apr 12.

National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, MD, USA. Electronic address:

Niemann-Pick disease type B (NPB) is a rare autosomal recessive lysosomal storage disease caused by mutations in the SMPD1 gene, which encodes for acid sphingomyelinase. A human induced pluripotent stem cell (iPSC) line was generated from dermal fibroblasts of a 1-year old male patient with NPB that has a heterozygous mutation of a p.L43_A44delLA of SMPD1 using non-integrating Sendai virus technique. Read More

Stem Cell Res 2019 Apr 13;37:101437. Epub 2019 Apr 13.

Coronary Care Unit, Laboratory of Experimental Cardiology for Cell and Molecular Therapy, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy; Department of Molecular Medicine, Unit of Cardiology, Università degli studi di Pavia, Pavia, Italy; Department of Medicine, University of Cape Town, Cape Town, South Africa. Electronic address:

We generated human induced pluripotent stem cells (hiPSCs) from dermal fibroblasts of a woman carrier of the heterozygous mutation c.568C > T p.R190W on the KCNQ1 gene. Read More

World Neurosurg 2019 Apr 19. Epub 2019 Apr 19.

Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China. Electronic address:

The indications for mechanical thrombectomy (MT) have expanded since the American Heart Association/American Stroke Association (AHA/ASA) published its first guideline on MT in 2013. Multiple subsequent randomized clinical trials of MT have proven its efficacy, including the DAWN and DEFUSE 3 trials. The current guideline from AHA/ASA provides Class I support for the use of MT for the following indications: 1. Read More

Ann Vasc Surg 2019 Apr 19. Epub 2019 Apr 19.

Department of Cardiothoracic Surgery St. Antonius Hospital, Nieuwegein; Department of Cardiothoracic Surgery, Amsterdam AMC, Amsterdam(+) The Netherlands.

Type A aortic dissection is a highly lethal condition, which warrants swift open surgical intervention to prevent death by rupture or malperfusion. Aim is to resect the proximal intimal tear and realign the dissected wall layers. We describe two patients who recently presented in our centre with a retrograde Type A intramural hematoma and a clear intimal tear distal to the left subclavian artery, that were treated in emergency by endovascular means instead of open surgery, with satisfactory short and one year follow-up results. Read More

Ann Vasc Surg 2019 Apr 19. Epub 2019 Apr 19.

Department of Vascular and Endovascular Surgery, University Hospital Regensburg, Germany.

Objective: In situ fenestration of aortic stent grafts for treatment of aortic arch aneurysms is a new option for endovascular aortic arch repair. So far, only few reports have shown perioperative and short term results of in situ fenestrations for aortic arch diseases. We present the multicenter experience with the (aortic archin situfenestration) technique documented in the AARCHIF registry for treatment of aortic arch aneurysms or localized type A aortic dissections and analyzed perioperative outcome and midterm follow up. Read More

Ann Vasc Surg 2019 Apr 19. Epub 2019 Apr 19.

Institute of Vascular Surgery, Department of Vascular Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.

Objective: Comparing perioperative and follow-up results of Carotid Artery Stenting (CAS) and Carotid Endarterectomy (CEA) in Patients with carotid near-occlusion (NO).

Methods: A retrospective analysis was conducted from January 2012 to June 2017 on consecutive NO patients in our center. Perioperative complications, recurrence rate of ischemic stroke, restenosis rate and mortality in follow-up were compared between CAS group and CEA group. Read More

Nitric Oxide 2019 Apr 19. Epub 2019 Apr 19.

New York University School of Medicine, New York, NY, USA.

Cancer development is closely related to chronic inflammation, which is associated with identifiable markers of tumor progression, such as uncontrolled cell proliferation, angiogenesis, genomic instability, chemotherapeutic resistance, and metastases. Redox processes mediated by reactive oxygen species (ROS) and nitric oxide (NO) within the inflammatory tumor microenvironment play an essential role in directly influencing intercellular and intracellular signaling. These reactive species originating in the cancer cell or its microenvironment, mediate the epithelial-mesenchymal transition (EMT) and the mesenchymal-epithelial transition (MET). Read More

J Card Fail 2019 Apr 19. Epub 2019 Apr 19.

Section of Cardiovascular Medicine, New Haven, CT; Center for Outcomes Research and Evaluation (CORE) at Yale University School of Medicine, New Haven, CT. Electronic address:

Resuscitation 2019 Apr 19. Epub 2019 Apr 19.

Department of Epidemiology and Preventive Medicine, Monash University, Australia; Prehospital, Resuscitation and Emergency Care Research Unit, Curtin University, Australia; Alfred Hospital, Australia; Ambulance Victoria, Australia; Department of Community Emergency Health and Paramedic Practice, Monash University, Australia; SA Ambulance Service, Australia; Flinders University, Australia; St John Ambulance Western Australia, Australia; Warwick University, United Kingdom.

Background: Experimental and observational research suggests hyperoxia following resuscitation from cardiac arrest is associated with neurological injury and worse clinical outcomes. This paper describes the rationale and design of the EXACT trial. EXACT aims to determine whether reducing oxygen in the acute phase of post-resuscitation care for out-of-hospital cardiac arrest (OHCA) improves survival. Read More

Resuscitation 2019 Apr 19. Epub 2019 Apr 19.

Department of Heart Disease, Haukeland University Hospital, Bergen, Norway; Department of Clinical Medicine, University of Bergen, Bergen, Norway.

Aims: To assess characteristics and outcome of patients treated with Impella for acute myocardial infarction (AMI) complicated by severe cardiogenic shock (CS) or cardiac arrest (CA).

Methods And Results: From 2008 through 2017, 92 patients with AMI complicated by CS were treated with Impella. Survival varied according to clinical presentation. Read More

Resuscitation 2019 Apr 19. Epub 2019 Apr 19.

Department of Emergency Medicine, University of Illinois at Chicago. Electronic address:

Background: Large cities pose unique challenges that limit the effectiveness of system improvement interventions. Successful implementation of integrated cardiac resuscitation systems of care can serve as a model for other urban centers.

Methods: This was a retrospective analysis of prospectively collected data of adult cases of non-traumatic cardiac arrest who received treatment by Chicago Fire Department EMS from September 1, 2013 through December 31, 2016. Read More

Resuscitation 2019 Apr 19. Epub 2019 Apr 19.

Department of Emergency Medicine, Seoul National University Boramae Medical Center, Seoul, Republic of Korea; Laboratory of Emergency Medical Services, Seoul National University Hospital Biomedical Research Institute, Seoul, Republic of Korea. Electronic address:

Background: Supraglottic airway devices (SGDs) are widely used during the resuscitation of out-of-hospital cardiac arrest (OHCA). The effect of SGDs on carotid blood flow (CBF) as resuscitation time passes is controversial. We assessed the effects of endotracheal intubation (ETI) and 3 types of SGD placement on CBF over time in prolonged resuscitation through an experimental porcine cardiac arrest study. Read More

Gene 2019 Apr 19. Epub 2019 Apr 19.

Diabetes Research Center, Health Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran; Department of Medical Genetics, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. Electronic address:

Background: Mucopolysaccharidosis (MPS) type VI, also known as Maroteaux-Lamy syndrome, is an autosomal recessive lysosomal storage disorder caused by a deficiency in arylsulfatase B (ARSB) enzyme. Our objectives were to investigate clinical phenotypes and performed molecular studies in Iranian patients with MPS VI, for the first time, in the southwestern Iran.

Methods: We studied 14 cases from 10 unrelated kindreds with MPS VI that were enrolled during 8 years. Read More

J Virol Methods 2019 Apr 19. Epub 2019 Apr 19.

Aquatic animal health and environment division, ICAR-Central Institute of Brackishwater Aquaculture, #75, Santhome High Road, Raja Annamalaipuram; Chennai, Tamil Nadu, 600028, India. Electronic address:

The lack of shrimp cell lines and difficulty in establishing shrimp cell culture systems, with an appropriate medium is a major concern in the aquaculture sector. The present study attempts to address this issue by developing an in vitro cell culture system from various tissues (hemocytes, heart, lymphoid tissue, hepatopancreas, gill, eye stalk, and muscle) of Penaeus vannamei (P.vannamei) using commercially available L-15 medium. Read More

Neurochem Int 2019 Apr 19. Epub 2019 Apr 19.

Ruhr University Bochum, Faculty of Chemistry and Biochemistry, Biochemistry II, Bochum, Germany; Ruhr University Bochum, International Graduate School for Neuroscience, Germany. Electronic address:

The sodium potassium ATPase (Na/K ATPase) is essential for the maintenance of a low intracellular Na and a high intracellular K concentration. Loss of function of the Na/K ATPase due to mutations in Na/K ATPase genes, anoxic conditions, depletion of ATP or inhibition of the Na/K ATPase function using cardiac glycosides such as digitalis, causes a depolarization of the resting membrane potential. While in non-excitable cells, the uptake of glucose and amino acids is decreased if the function of the Na/K ATPase is compromised, in excitable cells the symptoms range from local hyper-excitability to inactivating depolarization. Read More

Chem Biol Interact 2019 Apr 19. Epub 2019 Apr 19.

Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, Shenyang, Liaoning, China; Emergency Medicine Department of General Hospital of Northern Theater Command, Laboratory of Rescue Center of Severe Wound and Trauma PLA, 83 Wenhua Road, Shenhe District, Shenyang, China. Electronic address:

As a compensatory response to cardiac overload, cardiac hypertrophy is closely associated with the occurrence and development of a variety of cardiovascular diseases, in which histone deacetylase 2 (HDAC2) has been reported to play an important role. Plantamajoside (PMS) is an active component extracted from Herba Plantaginis, which is a traditional Chinese medicine, and many biological activities of PMS have been reported. Here, we investigated the effects and mechanism of PMS on isoproterenol (ISO)-induced cardiac hypertrophy. Read More

J Pediatr (Rio J) 2019 Apr 19. Epub 2019 Apr 19.

Universidade Federal do Rio de Janeiro (UFRJ), Departamento de Pediatria, Genética Clínica, Rio de Janeiro, RJ, Brazil.

Background: Duchenne muscular dystrophy, an X-linked genetic disease, leads to progressive muscle weakness mainly in the lower limbs. Motor function tests help to monitor disease progression. Can low-cost, simple assessments help in the diagnostic suspicion of Duchenne muscular dystrophy? The authors aim to define the sensitivity of time to rise from the floor, time to walk 10meters (10MWT), and time to run 10meters (10MRT), evaluating them as eventual diagnostic screening tools. Read More

J Mol Cell Cardiol 2019 Apr 19. Epub 2019 Apr 19.

Department of Allergy and Clinical Immunology, Graduate School of Medicine, Chiba University, Chiba, Japan. Electronic address:

Background: Various immune cells are involved in different phases of cardiac repair after myocardial infarction (MI). Especially, Ly6C M2-like macrophages (Ly6C macrophages) are vital for cardiac repair after MI. However, the molecular mechanisms how Ly6C macrophages promote wound healing after MI are still largely unknown. Read More

J Mol Cell Cardiol 2019 Apr 19. Epub 2019 Apr 19.

Faculty of Medicine, Department of Pharmacology, Center for Heart Failure Research, Oslo University Hospital, University of Oslo, Oslo, Norway.

Although only β-adrenergic receptors (βAR) dually couple with stimulatory G protein (G) and inhibitory G protein (G), inactivation of G enhances both βAR and βAR responsiveness. We hypothesize that G restrains spontaneous adenylyl cyclase (AC) activity independent of receptor activation. Subcellular localization of the AC5/6 subtypes varies contributing to the compartmentation of βAR signaling. Read More

Circulation 2019 Apr;139(17):1985-1987

Department of Cardiology, Keio University School of Medicine, Tokyo, Japan.

PLoS One 2019 22;14(4):e0215818. Epub 2019 Apr 22.

Cardiocirculatory Unit, Health Research Institute of La Fe University Hospital (IIS La Fe), Valencia, Spain.

This study aimed to analyze changes in the expression of autophagy- and phagocytosis-related genes in patients with dilated cardiomyopathy (DCM), especially in relation to left ventricular (LV) dysfunction. Furthermore, transmission electron microscopy of the diseased tissue was carried out to investigate if the gene expression changes are translated into ultrastructural alterations. LV tissue samples from patients with DCM (n = 13) and from controls (CNT; n = 10) were analyzed by RNA-sequencing, whereupon the altered expression (P < 0. Read More

PLoS One 2019 22;14(4):e0215636. Epub 2019 Apr 22.

Department of Ophthalmology, Medical Faculty Mannheim of the Ruprecht-Karls-University of Heidelberg, Mannheim, Germany.

Purpose: Non-communicable chronic diseases have become the leading causes of mortality and disease burden worldwide. With information about the frequency of diabetes as a major non-communicable chronic disease in Russia being scarce, we assessed the prevalence of diabetes and its associated factors in a rural and urban population in Russia.

Methods: The Ural Eye and Medical Study is a population-based study in the city of Ufa/Russia and in villages in a distance of 65 km from Ufa. Read More

PLoS One 2019 22;14(4):e0215094. Epub 2019 Apr 22.

Department of Anesthesiology and Intensive Care, Medical and Health Sciences, Linköping University, Linköping, Sweden.

Background: Increased postoperative cardiac troponin (cTn) independently predicts short-term mortality. Previous studies suggest that preoperative cTn also predicts major adverse cardiovascular events (MACE) and mortality after noncardiac surgery. The value of preoperative and perioperative changes in cTn as a prognostic tool for adverse outcomes has been sparsely investigated. Read More

J Strength Cond Res 2019 Apr 17. Epub 2019 Apr 17.

Laboratory of Neuromuscular Assessment, Department of Sports, Federal University of Pelotas, Pelotas, Brazil.

Alberton, CL, Andrade, LS, Pinheiro, RB, and Pinto, SS. Anaerobic threshold in a water-based exercise: agreement between heart rate deflection point and lactate threshold methods. J Strength Cond Res XX(X): 000-000, 2019-The purpose of this study was to compare and assess the agreement of the heart rate (HR) and rating of perceived exertion (RPE) corresponding to the anaerobic threshold (AT) between HR deflection point (HRDP) and lactate threshold (LT) methods during a water-based exercise in young men. Read More

J Strength Cond Res 2019 Apr 11. Epub 2019 Apr 11.

GIAFyS Cancer Foundation, Miranda de Ebro, Burgos, Spain.

Quevedo-Jerez, K, Gil-Rey, E, Maldonado-Martín, S, and Herrero-Román, F. Exercise-intensity adherence during aerobic training and cardiovascular response during resistance training in cancer survivors. J Strength Cond Res XX(X): 000-000, 2019-Combined aerobic-resistance training has shown the best benefits has proved beneficial for cancer survivors (CS). Read More

Coron Artery Dis 2019 Apr 19. Epub 2019 Apr 19.

Department of Internal Medicine and Cardiovascular Center, Seoul National University Hospital, Seoul, Republic of Korea.

Background: In patients with high bleeding risk, percutaneous coronary intervention is still debated. This study compared 9-month angiographic and physiologic results in patients with high bleeding risk and de novo coronary lesions treated with either paclitaxel-coated balloon (PCB) or bare-metal stent (BMS).

Patients And Methods: A total of 40 patients (40 lesions) with high bleeding risk who underwent successful balloon angioplasty with fractional flow reserve (FFR) after balloon angioplasty more than 0. Read More

J Thorac Imaging 2019 May;34(3):192-201

Department of Radiology, University of California San Diego.

Advances in technology have always had the potential and opportunity to shape the practice of medicine, and in no medical specialty has technology been more rapidly embraced and adopted than radiology. Machine learning and deep neural networks promise to transform the practice of medicine, and, in particular, the practice of diagnostic radiology. These technologies are evolving at a rapid pace due to innovations in computational hardware and novel neural network architectures. Read More

J Cardiopulm Rehabil Prev 2019 Apr 18. Epub 2019 Apr 18.

University of Vermont College of Medicine, Burlington (Drs Gaalema, Naud, Priest, and Ades); and University of Vermont Medical Center, Burlington (Messrs Savage and Rengo and Drs Leadholm and Ades).

Purpose: Clinical interventions in programs such as cardiac rehabilitation (CR) are guided by clinical characteristics of participating patients. This study describes changes in CR participant characteristics over 20 yr.

Methods: To examine changes in patient characteristics over time, we analyzed data from 1996 to 2015 (n = 5396) garnered from a systematically and prospectively gathered database. Read More

CMAJ 2019 Feb;191(5):E136-E137

Department of Family and Community Medicine, University of Toronto, Toronto, Ont.

Stroke 2019 May;50(5):1124-1129

From the Vascular Neurology, Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, China (X.-M.Y., X.-Q.Z., Y.-L.W., Z.-X.L., Y.-J.W.).

Background and Purpose- We aim to compare the risk of 1-year ischemic stroke recurrence and death for atrial fibrillation diagnosed after stroke (AFDAS), atrial fibrillation known before stroke (KAF), and sinus rhythm (SR). Methods- From June 2012 to January 2013, 19 604 patients with acute ischemic stroke were admitted to 219 urban hospitals in the China National Stroke Registry II. Based on heart rhythm assessed during admission, we classified patients as AFDAS, KAF, or SR. Read More

Stroke 2019 May;50(5):e142

Department of Cardiovascular Sciences, University of Leicester, United Kingdom.

Stroke 2019 May;50(5):1089-1094

Departments of Pediatrics, Neurology and Neurotherapeutics, University of Texas Southwestern Medical Center at Dallas and Children's Health Dallas (M.M.D.).

Background and Purpose- Sickle cell disease (SCD) and arteriopathy are pediatric stroke risk factors that are not mutually exclusive. The relative contributions of sickled red blood cells and arteriopathy to stroke risk are unknown, resulting in unclear guidelines for primary and secondary stroke prevention when both risk factors are present. We hypothesized that despite similarities in clinical presentation and radiographic appearance of arteriopathies, stroke evaluation and management differ in children with SCD compared with those without SCD. Read More

Stroke 2019 May;50(5):e140-e141

Department of Neurology, University Hospital Bern, Inselspital, University of Bern, Switzerland.

Acta Cardiol 2019 Apr 22:1-5. Epub 2019 Apr 22.

a Royal Brompton and Harefield NHS Foundation Trust , London , UK.

Nucleic Acid Ther 2019 Apr 22. Epub 2019 Apr 22.

1 Université de Versailles St- Quentin, U1179 INSERM, UFR des Sciences de la Santé, Montigny le Bretonneux, France.

Antisense oligonucleotides (ASOs) hold promise for therapeutic splice switching correction for genetic diseases, in particular for Duchenne muscular dystrophy (DMD), for which ASO-exon skipping represents one of the most advanced therapeutic strategies. We have previously reported the therapeutic potential of tricyclo-DNA (tcDNA) in mouse models of DMD, highlighting the unique pharmaceutical properties and unprecedented uptake in many tissues after systemic delivery, including the heart and central nervous system. TcDNA-ASOs demonstrate an encouraging safety profile and no particular class-related toxicity, however, when administered in high doses for several months, mild renal toxicity is observed secondary to predictable phosphorothioate (PS)-ASO accumulation in kidneys. Read More

J Urol 2019 Apr 22:101097JU0000000000000281. Epub 2019 Apr 22.

Department of Urology, Samsung Medical Center, Sungkyunkwan University School of Medicine , Seoul , Korea.

Purpose: We evaluated efficacy and safety of THVD-201, which is a combination of tolterodine 2 mg and pilocarpine 9 mg, vs. tolterodine monotherapy in overactive bladder patients.

Materials And Methods: A multicenter, randomized, double-blind, parallel, active-control study enrolled patients with overactive bladder symptoms. Read More

J Palliat Med 2019 Apr 22. Epub 2019 Apr 22.

2 Division of General Internal Medicine, Geriatrics, and Palliative Care, Department of Medicine, University of Virginia School of Medicine, Charlottesville, Virginia.

Responding to an epidemic of opioid-related deaths, guidelines and laws have been implemented to promote safe opioid prescribing practices. This study evaluates differences in screening practices and knowledge of laws between oncologists and cardiologists who prescribe opiates. Surveys regarding screening practices and knowledge of opioid prescribing laws were distributed in March 2017 to oncology and congestive heart failure (CHF) clinicians at the University of Virginia. Read More

Transpl Infect Dis 2019 Apr 22:e13098. Epub 2019 Apr 22.

Division of Infectious Diseases, Department of Medicine, Washington University School of Medicine, St Louis, Missouri, USA.

Tick-borne infections represent a significant health risk each year in the United States. Immunocompromised patients are typically at risk of more severe disease manifestations than their immunocompetent counterparts. Here we report a case of a newly emerging phlebovirus, Heartland virus, in a heart transplant recipient. Read More

Cell Microbiol 2019 Apr 22:e13033. Epub 2019 Apr 22.

Pulmonary Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.

Vibrio cholerae produced-Cholix toxin (Cholix) is a cytotoxin that ADP-ribosylates eukaryotic elongation factor 2, inhibiting protein synthesis, and inducing apoptosis. Here, we identified prohibitin (PHB) 1 and 2 as novel Cholix-interacting membrane proteins in immortalized human hepatocytes and HepG2 cells by Cholix immunoprecipitation assays. The expression level of PHB1 was decreased by Cholix after a 12 h incubation. Read More

Int J Clin Pract 2019 Apr 22:e13354. Epub 2019 Apr 22.

IRCCS Ospedale Policlinico San Martino Genoa, 10 largo Benzi, 16132, Genoa, Italy.

It is with great interest that we have read the article by Özlek and co-workers, who performed a post-hoc analysis of results from the APOLLON trial (A comPrehensive, ObserationaL registry of heart faiLure with mid-range and preserved ejection fractiON). The authors investigated in a real-world study (patients included in a registry) the effects of treatment of octogenarian individuals with heart failure (HF) with mid-range and preserved ejection fraction, and then, the authors compared the observation in elderly to younger subjects. Interestingly, the authors reported that elderly patients with HF were similarly treated as compared to younger patients (in terms of ACE-Is/ARBs, β-blockers, MRAs, digoxin, ivabradine and diuretics), thus suggesting adherence to guideline recommendations independently of the age of subjects. Read More

J Pineal Res 2019 Apr 22:e12581. Epub 2019 Apr 22.

State Key Laboratory for Oncogenes and Related Genes, Division of Cardiology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai Cancer Institute, Shanghai, China.

Rupture of vulnerable plaques is the main trigger of acute cardio-cerebral vascular events, but mechanisms responsible for transforming a stable atherosclerotic into a vulnerable plaque remain largely unknown. Melatonin, an indoleamine hormone secreted by the pineal gland, plays pleiotropic roles in the cardiovascular system; however, the effect of melatonin on vulnerable plaque rupture and its underlying mechanisms remain unknown. Here, we generated a rupture-prone vulnerable carotid plaque model induced by endogenous renovascular hypertension combined with low shear stress in hypercholesterolemic ApoE mice. Read More

Alcohol Clin Exp Res 2019 Apr 22. Epub 2019 Apr 22.

Olin Neuropsychiatry Research Center, Hartford Hospital/IOL, Hartford, CT, 06107.

Background: The underlying molecular mechanisms associated with alcohol use disorder (AUD) risk have only been partially revealed using traditional approaches such as univariate GWAS and linkage-based analyses. We therefore aimed to identify gene clusters related to EEG neurobiological phenotypes distinctive to individuals with AUD using a multivariate approach.

Methods: The current project adopted a bi-multivariate data-driven approach, parallel independent component analysis (para-ICA) to derive and explore significant genotype-phenotype associations in a case-control subset of the Collaborative Study on the Genetics of Alcoholism (COGA) dataset. Read More

Prenat Diagn 2019 Apr 22. Epub 2019 Apr 22.

Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Baylor College of Medicine and Texas Children's Hospital, Houston, TX.

Background: We aimed to present the natural history and outcomes of fetal primary pleural effusions (PPE).

Methods: Fetuses with prenatal diagnosis of PPE, delivered between January 2011 and June 2018 were included. Fetal PPE were separated into groups: resolved, stable or progressive. Read More

Equine Vet J 2019 Apr 22. Epub 2019 Apr 22.

Department of Clinical Sciences, Faculty of Veterinary Medicine and Animal Science, Swedish University of Agricultural Sciences, Uppsala, Sweden.

Background: Administration of pulsed inhaled nitric oxide (PiNO) improves arterial oxygenation in spontaneously breathing anaesthetised healthy horses and in horses undergoing colic surgery. However, because hypoventilation commonly occurs, horses are often mechanically ventilated to prevent hypercarbia.

Objectives: To evaluate the effects of PiNO on arterial oxygenation during anaesthesia in mechanically ventilated healthy horses and horses undergoing colic surgery. Read More

Eur Heart J 2019 Apr 21. Epub 2019 Apr 21.

Division of Cardiology and Metabolism at Department of Cardiology (CVK); and Berlin-Brandenburg Center for Regenerative Therapies (BCRT); German Centre for Cardiovascular Research (DZHK) partner site Berlin; Charité Universitätsmedizin Berlin, Germany.

J Clin Endocrinol Metab 2019 Apr 22. Epub 2019 Apr 22.

Center of Hypertension, 3rd Department of Medicine, First Faculty of Medicine and General Faculty Hospital, Charles University in Prague, Czech Republic.

Context: Impaired diurnal blood pressure (BP) variability is related to higher cardiovascular risk.

Objective: To assess diurnal variability of BP and its relation to target organ damage (TOD) and catecholamine phenotype in a consecutive sample of pheochromocytoma/paraganglioma (PPGL).

Design: We included 179 patients with PPGL (96 females). Read More

Medicine (Baltimore) 2019 Apr;98(16):e15300

Department of Nephrology, The Affiliated Hongqi Hospital of Mudanjiang Medical University, Mudanjiang, China.

Background: Previous clinical studies have reported that furosemide can be used to treat liver cirrhosis (LC) effectively. However, no study systematically explored this issue. This systematic review aims to investigate the efficacy and safety of furosemide for treatment of LC. Read More