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Neuropsychopharmacology 2020 Jul 1. Epub 2020 Jul 1.

Ottawa Hospital Research Institute, Neuroscience, University of Ottawa Brain and Mind Institute, Ottawa, ON, K1H 8M5, Canada.

Schizophrenia is a debilitating disorder affecting young adults displaying symptoms of cognitive impairment, anxiety, and early social isolation prior to episodes of auditory hallucinations. Cannabis use has been tied to schizophrenia-like symptoms, indicating that dysregulated endogenous cannabinoid signaling may be causally linked to schizophrenia. Previously, we reported that glutamatergic neuron-selective ablation of Lmo4, an endogenous inhibitor of the tyrosine phosphatase PTP1B, impairs endocannabinoid (eCB) production from the metabotropic glutamate receptor mGluR5. Read More

Gerontology 2020 Jul 1:1-13. Epub 2020 Jul 1.

Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria,

Atherosclerosis - the pathophysiological mechanism shared by most cardiovascular diseases - can be directly or indirectly assessed by a variety of clinical tests including measurement of carotid intima-media thickness, carotid plaque, -ankle-brachial index, pulse wave velocity, and coronary -artery calcium. The Prospective Studies of Atherosclerosis -(Proof-ATHERO) consortium (https://clinicalepi.i-med. Read More

Neuroepidemiology 2020 Jul 1:1-9. Epub 2020 Jul 1.

Department of Neuropediatrics, Children's Hospital at University Medical Center Homburg, Homburg, Germany.

Background: PHACE syndrome is a rare inborn condition characterized by large facial hemangiomas and variable malformations of the arterial system, heart, central nervous system, and eyes. According to Orphanet estimates, the prevalence is <1.0 per million. Read More

Horm Res Paediatr 2020 Jul 1:1-11. Epub 2020 Jul 1.

Hormone Research, Murdoch Children's Research Institute, Melbourne, Victoria, Australia,

Objective: To evaluate the impact of pubertal induction with testosterone on bone health, body composition, and motor function in boys with Duchenne muscular dystrophy (DMD) receiving long-term glucocorticoid.

Study Design: A retrospective, observational, pre-post study investigating the impact of testosterone therapy on bone mass accrual, vertebral fracture incidence, body composition, motor function, and quality of life in boys with DMD. All those boys aged ≥14 years, on chronic steroid therapy, who had delayed puberty, and were receiving oral testosterone or oral and then transitioned to intramuscular testosterone, to complete virilization, were included. Read More

J Invasive Cardiol 2020 Jul;32(7):E202

National University Heart Centre, Singapore, 1E Kent Ridge Road, NUHS Tower Block, Level 9, Singapore 119228.

J Invasive Cardiol 2020 Jul;32(7):E198

1st Cardiology Department, Red Cross Hospital, 1 Athanasaki St, 11521, Athens, Greece.

Percutaneous pseudoaneurysm repair through the ipsilateral ulnar artery is an alternative to surgical repair; however, distal radial access, as described in this case, may offer increased safety. Read More

J Invasive Cardiol 2020 Jul;32(7):E194-E195

Department of Cardiology, Advanced Cardiac Centre, Post Graduate Institute of Medical Education & Research, Sector 12, Chandigarh-160 012, India.

A calcified nodule is an infrequent pathological substrate in acute coronary syndrome patients. This case demonstrates the technical challenges of intervening an eccentric, severely calcified, balloon-uncrossable coronary lesion. Read More

J Invasive Cardiol 2020 Jul;32(7):E191-E192

Schulich Medicine & Dentistry Western University, London Health Sciences Centre, St. Joseph's Health Care, London, Canada.

Coronary-to-cardiac chamber fistulae and coronary aneurysms are potential complications after heart transplantation. In the setting of exercise intolerance and large fistulae at major coronary vessels, covered stents may provide an effective interventional strategy. Read More

J Invasive Cardiol 2020 Jul;32(7):E182-E185

Sentara Heart Valve and Structural Disease Center, Sentara Heart Hospital, 600 Gresham Drive, Norfolk, VA 23507 USA.

Background: Patient prosthesis mismatch (PPM) is an iatrogenic complication that occurs in patients who undergo surgical aortic valve replacement (SAVR). PPM occurs when the implanted surgical valve has an effective orifice area (EOA) that is too small for the patient, resulting in a gradient across the valve despite an otherwise normally functioning prosthesis. PPM has been associated with mid- and long-term increased morbidity and mortality. Read More

J Invasive Cardiol 2020 Jul;32(7):E178-E181

Division of Pediatric Cardiology, Columbia University Irving Medical Center, 3959 Broadway-2N, New York, NY 10032 USA.

Background: COVID-19 has led to major changes in hospital systems across the world. In an effort to reduce viral transmission, conserve resources, and in accordance with institutional and state mandates, all elective procedures and surgeries were postponed during the initial outbreak. Guidelines for case selection are limited and management for pediatric catheterization laboratories during this crisis is unprecedented. Read More

J Electrocardiol 2020 Jun 11;61:133-136. Epub 2020 Jun 11.

Arrhythmia Unit, Cardiology Department, Fundación Jiménez Díaz - Quirón Salud, Madrid, Spain.

Semin Thorac Cardiovasc Surg 2020 Jun 28. Epub 2020 Jun 28.

Alpert Medical School, Brown University, 2 Dudley Street, MOC Suite 360, Providence, Rhode Island 02905. Electronic address:

Semin Thorac Cardiovasc Surg 2020 Jun 28. Epub 2020 Jun 28.

Division of Congenital Heart Surgery, The Heart Center, Phoenix Children's Hospital, Phoenix, AZ. Electronic address:

Semin Thorac Cardiovasc Surg 2020 Jun 28. Epub 2020 Jun 28.

Division of Cardiac Surgery, Johns Hopkins Hospital, Baltimore, Maryland, USA. Electronic address:

The importance of postoperative nutrition support (NS) has been poorly recognized in cardiac surgery. In this population, we aim to describe the delivery of NS, factors affecting calorie/protein delivery and NS-associated morbidity. From January 2015 to January 2017, we prospectively observed all cardiac surgery patients at a single institution who could not take nutrition orally, requiring postoperative NS, either enteral or parenteral, for the duration of NS up to 14 days. Read More

Semin Thorac Cardiovasc Surg 2020 Jun 28. Epub 2020 Jun 28.

Department of Cardiovascular Surgery, Children's National Heart Institute, Children's National Hospital, The George Washington University School of Medicine and Health Sciences, Washington, DC, USA. Electronic address:

Semin Thorac Cardiovasc Surg 2020 Jun 28. Epub 2020 Jun 28.

Professor of Surgery Medical College of Wisconsin, Division of Pediatric Cardiothoracic Surgery, Herma Heart Institute, Children's Hospital of Wisconsin. Electronic address:

Semin Thorac Cardiovasc Surg 2020 Jun 28. Epub 2020 Jun 28.

Department of Cardiovascular Surgery, Marcus Valve Center, Piedmont Heart Institute, Atlanta, GA. Electronic address:

Semin Thorac Cardiovasc Surg 2020 Jun 28. Epub 2020 Jun 28.

Department of Cardiothoracic Surgery & Baptist Heart Failure and Transplant Institute, Baptist Health Medical Center, Little Rock, Arkansas; Division of Cardiovascular Surgery, University of Arkansas for Medical Sciences, Little Rock, Arkansas. Electronic address:

Semin Thorac Cardiovasc Surg 2020 Jun 28. Epub 2020 Jun 28.

Department of Cardiac Surgery, Kerckhoff Clinic, Campus Bad Nauheim, University of Giessen, Germany. Electronic address:

J Pediatr 2020 Jun 28. Epub 2020 Jun 28.

Pediatrics (Cardiology) and Medicine at Columbia University Irving Medical Center, New York, New York, USA.

Heart Rhythm 2020 Jun 28. Epub 2020 Jun 28.

Department of Medicine, University of Minnesota, Minneapolis, MN, USA; Division of Cardiology, Minneapolis VA Health Care System, Minneapolis, MN, USA. Electronic address:

Background: Hydroxychloroquine (HCQ) has been promoted as a potential treatment for COVID-19 but there are safety concerns.

Objectives: To determine the effect of HCQ treatment on QT interval METHODS: We retrospectively studied the electrocardiograms of 819 patients treated with HCQ for rheumatologic diseases from 2000 to 2020. The primary outcome was corrected QT (QTc) interval, by Bazett formula, during HCQ therapy. Read More

Int J Cardiol 2020 Jun 28. Epub 2020 Jun 28.

Department of Cardiovascular Medicine, Kobe City Medical Center General Hospital, Kobe, Japan.

Background: Little is known about the outcomes and predictors of adverse cardiac events in medically treated patients with atrial functional mitral regurgitation (FMR).

Methods: We screened 1405 consecutive patients with grade ≥ 3+ mitral regurgitation (MR) detected by echocardiography. After excluding patients with previous or early (within 3 months from diagnosis) mitral valve surgery, congenital heart disease, hypertrophic cardiomyopathy, severe aortic valve disease, or unknown etiology, the study population consisted of 319 patients with primary MR, 395 patients with FMR with left ventricular (LV) dysfunction, and 184 patients with atrial FMR. Read More

Int J Cardiol 2020 Jun 28. Epub 2020 Jun 28.

Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular Disease, Department of Cardiology, Tianjin Institute of Cardiology, the Second Hospital of Tianjin Medical University, Tianjin, China. Electronic address:

Int J Cardiol 2020 Jun 28. Epub 2020 Jun 28.

Center for Primary Health Care Research, Lund University, Malmö, Sweden.

Background: Aortic stenosis (AS) is the most common valvular heart disease in developed countries, confers high mortality in advanced cases, but can effectively be reversed using endovascular or open-heart surgery. We evaluated the association between AS and neighborhood socioeconomic status (NSES).

Methods: We used Swedish population-based nationwide registers and an echocardiography screening cohort during the study period 1997-2014. Read More

Cell Rep 2020 Jun;31(13):107837

Unit on Structural and Chemical Biology of Membrane Proteins, Neurosciences and Cellular and Structural Biology Division, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address:

Autophagy is a catabolic process involving capture of cytoplasmic materials into double-membraned autophagosomes that subsequently fuse with lysosomes for degradation of the materials by lysosomal hydrolases. One of the least understood components of the autophagy machinery is the transmembrane protein ATG9. Here, we report a cryoelectron microscopy structure of the human ATG9A isoform at 2. Read More

Can J Cardiol 2020 Jan 13. Epub 2020 Jan 13.

Toronto Congenital Cardiac Centre for Adults, Peter Munk Cardiac Centre, Toronto General Hospital, University Health Network, Toronto, Ontario, Canada. Electronic address:

Background: Recent randomized trials have confirmed the role of patent foramen ovale (PFO) closure in the secondary prevention of cryptogenic stroke. Guidelines have suggested a central role for intraprocedural imaging using intracardiac echocardiography (ICE). However, this modality may not be required to achieve safe and effective closure. Read More

Can J Cardiol 2020 Feb 11. Epub 2020 Feb 11.

Department of Cardiology, Christian Medical College Vellore, Tamil Nadu, India. Electronic address:

Background: Published data on the clinical, electrocardiographic, and angiographic profile of acute anterior-wall ST-elevation myocardial infarction (STEMI) with right bundle branch block with q in leads V1, V2 (qRBBB) are scarce. The aim of this study was to estimate the incidence of short-term mortality and in-hospital complications in acute qRBBB STEMI and identify the electrocardiographic (ECG) predictors of a poor outcome.

Methods: We conducted a single-centre retrospective study among the patients with acute anterior-wall STEMI and qRBBB pattern on ECG. Read More

Cortex 2020 May 30;130:16-31. Epub 2020 May 30.

Developmental Clinical Psychology Research Unit, Faculty of Psychology and Educational Sciences (FPSE), University of Geneva, Geneva, Switzerland.

Embodied models of social cognition argue that others' emotional states are processed by re-enacting a representation of the same state in the observer, along with associated somatic and physiological responses. In this framework, previous studies tested whether a strong sensitivity to interoceptive signals (i.e. Read More

Peptides 2020 Jun 28:170352. Epub 2020 Jun 28.

Frontier Science Research Center, University of Miyazaki Faculty of Medicine, Cardiovascular Medicine, University of Miyazaki Hospital, 5200 Kihara, Kiyotake, Miyazaki 889-1692, Japan. Electronic address:

The family of natriuretic peptides (NPs) discovered in mammalian tissues including cardiac atrium and brain consists of three members, namely, atrial, B- and C-type natriuretic peptides (ANP, BNP, CNP). Since the discovery, basic and clinical studies have been vigorously performed to explore the biological functions and pathophysiological roles of NPs in a wide range of diseases including hypertension and heart failure. These studies revealed that ANP and BNP are hormones secreted from the heart into the blood stream in response to pre- or after-load, counteracting blood pressure (BP) elevation and fluid retention through specific receptors. Read More

Int J Psychophysiol 2020 Jun 28. Epub 2020 Jun 28.

Pauley Heart Center, Virginia Commonwealth University, United States of America.

Previous research suggests that vagal activity and executive function (EF) are positively associated. However, existing data exploring the relationship between HRV and EF remains limited. Though Blacks may have higher HRV, they remain underrepresented in previous research examining HRV and EF. Read More

Ann Am Thorac Soc 2020 Jul 1. Epub 2020 Jul 1.

The University of British Columbia Faculty of Medicine, 12358, Vancouver, British Columbia, Canada.

J Dermatolog Treat 2020 Jul 1:1-40. Epub 2020 Jul 1.

Department of Dermatology, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China.

Psoriasis Vulgaris (PV) not only affects patients' skin health but also increases the risk of coronary heart disease and diabetes, which brings both physical and mental harms. Its pathogenesis is complex, and the multi-target effect of traditional Chinese medicine (TCM) is especially advantageous. Because a considerable number of randomized controlled trials related to TCM exhibit design defects, small sample size or inadequate intervention time, so the status of TCM in the treatment of PV cannot be fully clarified. Read More

J Ultrason 2020 15;20(81):e116-e121. Epub 2020 Jun 15.

Department of Gynaecology And Obstetrics, Aziz Medical Center , Karachi , Pakistan.

To assess the effect of ultrasound-guided cervical dilation on clinical pregnancy rates in women with cervical stenosis. A prospective case control study was conducted in women with unexplained infertility. These women underwent saline infusion sonography and were suspected of having cervical stenosis if a 7 French Foley's catheter could not be introduced into the cervical canal. Read More

J Ultrason 2020 15;20(81):e111-e115. Epub 2020 Jun 15.

University Institute of Radiological Sciences and Medical Imaging Technologies, Faculty of Allied Health Sciences, The University of Lahore , Lahore , Pakistan.

To determine the association between spectral Doppler cardiac activity in the lower limb veins and echocardiographic findings in patients with tricuspid regurgitation. A cross-sectional analysis was performed in the Gilani Ultrasound Center over a period of 13 months. The total study sample comprised 400 subjects. Read More

Mol Nutr Food Res 2020 Jul 1:e2000325. Epub 2020 Jul 1.

Department of Food Chemistry, Institute of Nutritional Science, University of Potsdam, Arthur-Scheunert-Allee 114-116, Nuthetal, 14558, Germany.

Scope: Trace element (TE) deficiencies often occur accumulated, as nutritional intake is inadequate not for one but several TEs, concurrently. Therefore, we studied the impact of a suboptimal supply of Fe, Zn, Cu, I, and Se on the TE status, health parameters, epigenetics, and genomic stability in mice.

Methods And Results: Male mice received reduced or adequate amounts of TEs for nine weeks. Read More

Cochrane Database Syst Rev 2020 Jul 1;7:CD012787. Epub 2020 Jul 1.

Department of Anesthesiology, Pharmacology and Therapeutics, University of British Columbia, Vancouver, Canada.

Background: Alcohol is consumed by over 2 billion people worldwide. It is a common substance of abuse and its use can lead to more than 200 disorders including hypertension. Alcohol has both acute and chronic effects on blood pressure. Read More

J Am Geriatr Soc 2020 Jul 1. Epub 2020 Jul 1.

Center for Health Equity Promotion and Research, Corporal Michael Crescenz VA Medical Center, Philadelphia, Pennsylvania, USA.

Background/objectives: Prognostic tools are needed to identify patients at high risk for adverse outcomes receiving post-acute care in skilled nursing facilities (SNFs) and provide high-value care. The SNF Prognosis Score was developed in a Medicare sample to predict a composite of long-term SNF stay, hospital readmission, or death during the SNF stay. Our goal was to evaluate the score's performance in an external validation cohort. Read More

Br J Haematol 2020 Jul 1. Epub 2020 Jul 1.

Division of Renal Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States.

Blood groups are inherited traits that vary across populations, likely due to both founder effects and natural selection. A link between blood groups and susceptibility to infectious disease has been well-described, with notable examples being H. Pylori and Plasmodium falciparum infection. Read More

Lab Chip 2020 Jul 1. Epub 2020 Jul 1.

Department of Biomedical Engineering, City University of Hong Kong, 83 Tat Chee Avenue, Kowloon Tong, Hong Kong, China.

Cardiovascular disease is a chronic disease that leads to impaired cardiac function and requires long-term management to control its progression. Despite the importance of hydrogels for therapeutic applications, a contradiction between the size of a hydrogel and the amount of loaded drug has been encountered when using conventional fabrication methods. In this study, biocompatible reservoir microcapsules (diameter ∼100 μm) with a large liquid core and polymeric shell were fabricated via a one-step phase separation of poly(ethylene glycol)diacrylate (PEGDA) and dextran within pre-gel droplets through microfluidics. Read More

PLoS One 2020 1;15(7):e0234600. Epub 2020 Jul 1.

CentERdata, Tilburg, The Netherlands.

Objectives: Assess how people perceive the risks of coronavirus infection, whether people take preventive measures, and which pre-outbreak factors contribute to the perceived risks and measures taken, such as pre-outbreak respiratory problems, heart problems, diabetes, anxiety and depression symptoms, loneliness, age, gender, marital and employment status and education level.

Methods: Data were collected in the longitudinal LISS panel, based on a random sample of the Dutch population. The coronavirus survey started on March 2, and the data collection ended on March 17 2020. Read More

PLoS One 2020 1;15(7):e0235546. Epub 2020 Jul 1.

Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, United States of America.

Resistin and resistin-like molecules are pleiotropic cytokines that are involved in inflammatory diseases. Our previous work suggested that resistin has the potential to be used as a biomarker and therapeutic target for human pulmonary arterial hypertension. However, data are limited on the distribution of resistin in healthy human organs. Read More

J Perinat Med 2020 Jun 29. Epub 2020 Jun 29.

Department of Obstetrics, Paulista School of Medicine - Federal University of São Paulo (EPM-UNIFESP), São Paulo-SP, Brazil.

Objectives This study aimed to establish reference ranges for fetal mitral, tricuspid, and interventricular septum annular plane systolic excursions (MAPSE, TAPSE, and SAPSE) in normal pregnant women between 20 and 36 + 6 weeks of gestation. Methods This prospective and cross-sectional study included 360 low-risk singleton pregnancies between 20 and 36 + 6 weeks of gestation. MAPSE, TAPSE, and SAPSE were measured by M-mode in real time in an apical or basal four-chamber view through placing the cursor at the atrioventricular junction, marked by the valve rings at the tricuspid, mitral, and basal septum, respectively. Read More

Radiographics 2020 Jul-Aug;40(4):982-1002

From the Department of Radiology, Hospital San Juan de Dios, Hospital de la Cruz Roja, RESSALTA HT Médica, Avenida el Brillante 36, 14012 Córdoba, Spain (J.B.); Cardiothoracic Imaging Section, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Mo (S.B., F.R.G.); Department of Radiology, University of Colorado-Anschutz Medical Campus, Aurora, Colo (D.V.); Department of Radiology, Mayo Clinic, Rochester, Minn (E.E.W.); Cardiovascular Division, Barnes Jewish Heart and Vascular Center, St Louis, Mo (M.M.); and MRI Section, Department of Radiology, Clínica Las Nieves, SERCOSA HT Médica, Jaén, Spain (A.L.).

Pulmonary hypertension (PH) is a disease characterized by progressive rise of pulmonary artery (PA) pressure, which can lead to right ventricular (RV) failure. It is usually diagnosed late because of the nonspecificity of its symptoms. RV performance and adaptation to an increased afterload, reflecting the interaction of the PA and RV as a morphofunctional unit, constitute a critical determinant of morbidity and mortality in these patients. Read More

Am J Physiol Lung Cell Mol Physiol 2020 Jul 1. Epub 2020 Jul 1.

Department of Cellular and Integrative Physiology, University of Nebraska, United States.

Clin Toxicol (Phila) 2020 Jul 1:1-7. Epub 2020 Jul 1.

Department of Cardiology and Internal Medicine, Wexham Park Hospital, Frimley Health NHS Foundation Trust, Slough, UK.

The neurocognitive benefits of donepezil are well recognised, but the potential side effects on cardiac conduction remain unclear. To investigate whether long-term donepezil therapy is associated with electrocardiographic (ECG) changes and in particular to assess its effects on the QT interval. We conducted a single centre retrospective analysis of patients admitted to our trust on donepezil therapy over a 12-month period. Read More

Am J Physiol Regul Integr Comp Physiol 2020 Jul 1. Epub 2020 Jul 1.

Heart and Vascular Institute, Penn State College of Medicine, United States.

Purinergic 2X receptors (P2X) on the endings of group III and IV afferents play a role in evoking the exercise pressor reflex. Particular attention has been paid to P2X3 receptors because their blockade in the periphery attenuated this reflex. In contrast, nothing is known about the role played by P2X receptors in the spinal cord in evoking the exercise pressor reflex in rats. Read More

Am J Physiol Regul Integr Comp Physiol 2020 Jul 1. Epub 2020 Jul 1.

HP2 Laboratory, Grenoble Alpes University, INSERM, France.

Background: While severe intermittent hypoxia (IH) is well known to induce deleterious cardiometabolic consequences, moderate IH may induce positive effects in obese individuals. The present study aimed to evaluate the effect of two hypoxic conditioning programs on cardiovascular and metabolic health status of overweight or obese individuals.

Methods: In this randomized single-blind controlled study, 35 subjects (54±9. Read More

Environ Sci Technol 2020 Jul 1. Epub 2020 Jul 1.

Although the bioaccumulation of organophosphate flame retardants (OPFRs) in aquatic organisms has been investigated, little information is available about their bioaccumulation in mammals following chronic inhalation exposure. To address this knowledge gap, C57BL/6 mice were exposed to 7 PM2.5-associated OPFRs via the trachea to study their bioaccumulation, tissue distribution and urinary metabolites. Read More

ACS Nano 2020 Jul 1. Epub 2020 Jul 1.

Stem-cell based in vitro differentiation for disease modeling offers great value to explore the molecular and functional underpinnings driving many types of cardiomyopathy and congenital heart diseases. Nevertheless, one major caveat in the application of in vitro differentiation of human induced pluripotent stem cell (hiPSC) derived cardiomyocytes (hiPSC-CMs) involves the immature phenotype of the CMs. Most of the existing methods need complex apparatus and require laborious procedures in order to monitor the cardiac differentiation/maturation process and often result in cell death. Read More

J Cardiovasc Nurs 2020 Jun 23. Epub 2020 Jun 23.

Sherri Shih-Fan Yeh, MD Attending physician, Department of Environmental and Occupational Medicine, National Taiwan University Hospital Hsin-Chu Branch, Hsin-Chu, Taiwan. Ching-Yu Julius Chen, MD Attending physician, Cardiovascular Center and Division of Cardiology, Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan. I-Chien Wu, MD, PhD Assistant investigator, Institute of Population Health Sciences, National Health Research Institutes, Zhunan, Taiwan. Chih-Cheng Hsu, MD, PhD Deputy director, Institute of Population Health Sciences, National Health Research Institutes, Zhunan, Taiwan. Tzu-Yu Chen, PhD Postdoctoral researcher, Institute of Population Health Sciences, National Health Research Institutes, Zhunan, Taiwan. Wei-Ting Tseng, PhD Postdoctoral researcher, Institute of Population Health Sciences, National Health Research Institutes, Zhunan, Taiwan. Feng-Cheng Tang, MD, PhD Associate professor, Department of Occupational Medicine, Changhua Christian Hospital, Changhua, Taiwan Chi-Chung Wang, MD, PhD Attending physician, Department of Family Medicine, Mennonite Christian Hospital, Hualien, Taiwan. Chung-Chou Juan, MD, PhD Associate professor, Department of Surgery, Yuan's General Hospital, Kaohsiung, Taiwan. Hou-Chang Chiu, MD, PhD Professor, Department of Neurology, Shin Kong Wu Ho Su Memorial Hospital, Taipei, and College of Medicine, Fu-Jen Catholic University, New Taipei City, Taiwan. Huey-Ming Lo, MD, PhD Professor, Section of cardiology, Department of Internal Medicine, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, and School of Medicine, Fu-Jen Catholic University, New Taipei City, Taiwan. Dun-Hui Yang, MD Attending physician, Department of Radiology, Tainan Municipal Hospital, Tainan, Taiwan. Jyh-Ming Jimmy Juang, MD, PhD Associate professor, Cardiovascular Center and Division of Cardiology, Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan. Chao Agnes Hsiung, PhD Director, Institute of Population Health Sciences, National Health Research Institutes, Zhunan, Taiwan.

Background: Brugada syndrome is a disorder associated with sudden cardiac death and characterized by an abnormal electrocardiogram (ECG). Previous studies were predominantly conducted in men, and the data on long-term prognosis are limited. Information about women, especially elderly women, is lacking. Read More